Polycarboxylic Acid Patents (Class 560/44)
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Patent number: 5075491Abstract: A composition useful for incorporation into polymer compositions employed for food packaging or the like comprising a bis- or tris-methine compound having the structural formula ##STR1## wherein A is selected from the radicals ##STR2## wherein R' and R" are each selected from chlorine, bromine, fluorine, alkyl, alkoxy, aryl, aryloxy and arylthio;each n is independently 0, 1, 2;R.sub.1 is selected from a large variety of radicals such as cycloalkyl, phenyl, and straight or branched alkyl which may be substituted;R.sub.2 is alkylene or the like;R.sub.3, R.sub.4, and R.sub.5 are each selected from hydrogen and alkyl; andP and Q and P.sup.1 and Q.sup.1 are selected from cyano, carbalkoxy, carbaryloxy, carbaralkyloxy, or the like.Type: GrantFiled: December 20, 1989Date of Patent: December 24, 1991Assignee: Eastman Kodak CompanyInventors: Max A. Weaver, Wayne P. Pruett, Samuel D. Hilbert
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Patent number: 5066823Abstract: A process for the preparation of 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives of formula (I), wherein X is I or Br, R is H or a variously substituted alkyl, or a group of formula (II), wherein X has the above meanings; Y is hydroxy, alkoxy, hydroxyalkoxy, alkylamino or hydroxyalkylamino; Z may be the same as COY or it is hydroxylalkylaminocarbonyl provided that at least one of the two acyl or R groups is hydroxy-substituted, which process comprises the rearrangement of the corresponding 5-(alkylaminocarbonyl-alkoxy)-2,4,6-trioodo ro tribromo-benzoic acid derivatives, in the presence of bases.Type: GrantFiled: October 10, 1989Date of Patent: November 19, 1991Assignee: Bracco Industria Chemica S.p.A.Inventors: Ernest Felder, Carlo Musu, Luciano Fumagalli, Fulvio Uggeri
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Patent number: 5066824Abstract: The present invention is directed to a process for preparing amine terminated compounds by reacting a polyfunctional acetoacetic acid ester with either ammonia or an organic compound which contains one or more primary amino groups in the presence of a solvent and an acidic catalyst selected from the group consisting of (i) boron trifuloride etherate and (ii) organic acids having pKa values of from 0.1 to 0.8 with the proviso that if the primary amino group containing compound contains no aromatically bound amino groups, the pKa of said organic acid is from 0.1 to less than 0.7.Type: GrantFiled: August 3, 1990Date of Patent: November 19, 1991Assignee: Mobay CorporationInventors: Robson Mafoti, Josef Sanders
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Patent number: 5036104Abstract: 2-Acylaminoalkyl-3-[1-(carboxycycloalkylcarbamoyl)cycloalkyl]propanoic acid derivatives (which may also be viewed as glutaramide derivatives) are useful in the treatment of hypertension, heart failure and renal insufficiency, based upon their inhibition of zinc-dependent, neutral endopiptidase.Type: GrantFiled: June 14, 1990Date of Patent: July 30, 1991Assignee: Pfizer Inc.Inventors: John C. Danilewicz, Keith James
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Patent number: 5001254Abstract: The present invention relates to novel methods for the preparation of quinoline-2,3-dicarboxylic acid, useful for the preparation of the highly effective 2-(2-imidazolin-2-yl)quinoline-3-carboxylic acid herbicidal agents.Type: GrantFiled: May 19, 1988Date of Patent: March 19, 1991Inventor: Donald R. Maulding
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Patent number: 4996350Abstract: The present invention relates to an improved method for the preparation of dialkyl dichlorosuccinates by chlorination of a dialkyl maleate in the presence of a catalytic amount of a C.sub.1 -C.sub.4 alkyl alcohol in the absence of a solvent which are useful intermediates in the preparation of anilinofumarates. Anilinofumarates are, in turn, used in the preparation of 2-(2-imidazolin-2-yl)quinoline-3-carboxylic acid herbicidal agents.Type: GrantFiled: November 17, 1989Date of Patent: February 26, 1991Assignee: American Cyanamid CompanyInventor: Albert A. Cevasco
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Patent number: 4981997Abstract: A process for the preparation of 2,5-diarylaminoterephthalic acids by oxidation of 2,5-diarylamino-3,6-dihydroterephthalic acid esters using oxygen or oxygen-containing gases, preferably air, in alcoholic-alkaline or alcoholic-aqueous-alkaline solution or suspension in the presence of an oxygen-transferring agent and working up to give the 2,5-diarylaminoterephthalic acids, characterized in that the oxidation is carried out in the presence of quaternary ammonium compound.Type: GrantFiled: September 29, 1989Date of Patent: January 1, 1991Assignee: Bayer AktiengesellschaftInventors: Detlef-Ingo Schutze, Reinold Schmitz
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Patent number: 4958043Abstract: A composition useful for incorporation into polymer compositions employed for food packaging or the like comprising a bis- or tris-methine compound having the structural formula ##STR1## wherein A is selected from the radicals ##STR2## wherein R' and R" are each selected from chlorine, bromine, fluorine, alkyl, alkoxy, aryl, aryloxy and arylthio;each n is independently 0, 1, 2;R.sub.1 is selected from a large variety of radicals such as cycloalkyl, phenyl, and straight or branched alkyl which may be substituted;R.sub.2 is alkylene or the like;R.sub.3, R.sub.4, and R.sub.5 are each selected from hydrogen and alkyl; andP and Q and P.sup.1 and Q.sup.1 are selected from cyano, carbalkoxy, carbaryloxy, carbaralkyloxy, or the like.The invention compositions are especially useful in combination with molding or fiber-grade condensation polymer; most preferably such polymer having copolymerized therein a total of from 1.Type: GrantFiled: April 18, 1988Date of Patent: September 18, 1990Assignee: Eastman Kodak CompanyInventors: Max A. Weaver, Wayne P. Pruett, Samuel D. Hilbert
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Patent number: 4910327Abstract: There are provided novel alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid; novel dialkyl 3-(substituted)phenylaminobut-2-ene-dioates, useful as intermediates for the preparation of highly effective 2-(2-imidazolin-2-yl)quinoline herbicidal agents and methods for the preparation thereof.Type: GrantFiled: March 27, 1989Date of Patent: March 20, 1990Assignee: American Cyanamid CompanyInventor: Robert F. Doehner, Jr.
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Patent number: 4906662Abstract: Disclosed are phenol derivatives of the formula ##STR1## wherein R.sup.1 is a substituted phenyl group, R.sup.2 and R.sup.3 are C.sub.1 -C.sub.6 alkyl group and of the formula ##STR2## wherein R.sup.8, R.sup.9 and R.sup.10 are C.sub.1 -C.sub.6 alkyl and the like and A is H, C.sub.1 -C.sub.6 alkylsulfonyl and the like substituents. These compounds and some related compounds have anti-inflammatory activity and lipoxygenase inhibitory activity.Type: GrantFiled: January 27, 1987Date of Patent: March 6, 1990Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Kinji Hashimoto, Kiyoto Goto, Ken-ichi Kanai, Yoshiaki Tsuda
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Patent number: 4904816Abstract: There is provided a novel process for the manufacture of anilinofumarate via chloromaleate or chlorofumarate or mixtures thereof.Type: GrantFiled: June 15, 1989Date of Patent: February 27, 1990Assignee: American Cyanamid CompanyInventors: Albert A. Cevasco, Donald Roy
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Patent number: 4889855Abstract: Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein --A-- together with the two carbon atoms denoted as 1 and 2 is selected from ##STR2## R.sup.1, R.sup.2 and R.sup.3 are independently H, halogen, CN, NH.sub.2, NO.sub.2, SO.sub.3 H, SO.sub.2 NH.sub.2, or CONH.sub.2The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use.The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters.Type: GrantFiled: February 16, 1988Date of Patent: December 26, 1989Assignee: A/S FerrosanInventors: Poul Jacobsen, Flemming E. Nielsen, Tage Honore
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Patent number: 4889947Abstract: Sunscreen compositions are described which contain certain substituted naphthalenylidenes which act as UV filters when incorporated in a carrier in amounts ranging from 0.1-50% by weight.Type: GrantFiled: July 28, 1988Date of Patent: December 26, 1989Assignee: ICI Americas Inc.Inventors: Charalambos J. Phalangas, Thomas P. Cleary
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Process for producing higher molecular weight amino compounds having reduced monomeric amine content
Patent number: 4855504Abstract: High molecular weight amines having reduced low molecular weight amine contents are obtained by reacting a mixture of (1) a high molecular weight amine and (2) a low molecular weight amine with (3) an isocyanate in quantities such that from 0.5 to 10 equivalents of isocyanate are present for each equivalent of low molecular weight amine. The product of high molecular weight amines is particularly useful in the production of isocyanate addition products such as polyurethane plastics and foams.Type: GrantFiled: September 23, 1985Date of Patent: August 8, 1989Assignee: Bayer AktiengesellschaftInventors: Werner Rasshofer, Ernst Grigat, Gerhard Grogler, Heinrich Hess, Richard Kopp -
Patent number: 4847405Abstract: The present invention relates to novel methods for the preparation of anilinofumarate [quinoline- 2,3-dicarboxylic acid], a useful intermediate in the preparation of 2-(2-imidazolin-2-yl)-quinoline-3-carboxylic acid herbicidal agents.Type: GrantFiled: March 19, 1987Date of Patent: July 11, 1989Assignee: American Cyanamid CompanyInventor: Donald R. Maulding
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Patent number: 4843162Abstract: There are provided novel alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid; novel dialkyl 3-(substituted)phenylamino-2-ene-dioates, useful as intermediates for the preparation of highly effective 2-(2-imidazolin-2-yl)quinoline herbicidal agents and methods for the preparation thereof.Type: GrantFiled: February 21, 1987Date of Patent: June 27, 1989Assignee: American Cyanamid CompanyInventor: Robert F. Doehner, Jr.
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Patent number: 4837353Abstract: 2-(N-Phenylakyl-N-formyl)amino-3-hydroxy-2-propenoic acids are intermediates for mercaptoimidazolecarboxylic acids which are dopamine-.beta.-hydroxylase inhibitors.Type: GrantFiled: January 21, 1988Date of Patent: June 6, 1989Assignee: SmithKline Beckman CorporationInventors: Joseph A. Finkelstein, Lawrence I. Kruse, Thomas B. Leonard
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Patent number: 4824995Abstract: A poly-p-phenylamino carboxylate having the following structure: ##STR1## wherein n is greater than 1; R is a C.sub.1 to C.sub.6 alkyl group; and R.sub.1 and R.sub.Type: GrantFiled: May 9, 1988Date of Patent: April 25, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventor: Neville E. Drysdale
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Patent number: 4814486Abstract: The present invention relates to an improved method for the preparation of anilinofumarates useful as intermediates in the preparation of 2-(2-imidazolin-2-yl) quinoline-3-carboxylic acid herbicidal agents.Type: GrantFiled: October 1, 1987Date of Patent: March 21, 1989Assignee: American Cyanamid CompanyInventors: Donald R. Maulding, Albert A. Cevasco
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Patent number: 4738787Abstract: The present application relates to cationic block polyesters useful as soil relese agents, softeners and antistatic agents. In addition to cleaning performance, laundry detergent compositions should have other benefits. One is the ability to impart soil release properties to fabrics woven from polyester fibers.Type: GrantFiled: May 26, 1987Date of Patent: April 19, 1988Assignee: Alkaril Chemicals Inc.Inventors: Anthony J. O'Lenick, Jr., Joseph J. Fanelli
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Patent number: 4716178Abstract: Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a group which includes carboxyl, tetrazolyl or N-methyltetrazolyl are useful as inhibitors of leukotriene synthesis and as antiallergic agents. Pharmaceutical compositions containing such compounds and pharmacological methods for use of such compounds are also disclosed.Type: GrantFiled: August 27, 1986Date of Patent: December 29, 1987Assignee: Riker Laboratories, Inc.Inventors: Robert A. Scherrer, Mark A. Rustad
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Patent number: 4675432Abstract: The present invention relates to methods for the preparation of anilinofumarate, a useful intermediate in the preparation of quinoline-2,3-dicarboxylic acid and in the preparation of 2-(2-imidazolin-z-yl) quinoline-3-carboxylic acid herbicidal agents.Type: GrantFiled: August 29, 1986Date of Patent: June 23, 1987Assignee: American Cyanamid CompanyInventor: Donald R. Maulding
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Patent number: 4656283Abstract: There are provided novel alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid; novel dialkyl 3-(substituted)phenylaminobut-2-ene-dioates, useful as intermediates for the preparation of highly effective 2-(2-imidazolin-2-yl)quinoline herbicidal agents and methods for the preparation thereof.Type: GrantFiled: February 4, 1985Date of Patent: April 7, 1987Assignee: American Cyanamid CompanyInventor: Robert F. Doehner, Jr.
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Patent number: 4617291Abstract: Dipeptides having the formula ##STR1## wherein A is halogen, hydrogen, lower alkyl, or lower alkoxy; B is hydrogen or lower alkyl, or A and B are taken together to form an ortho-methylene or ethylene bridge; R is hydrogen, lower alkyl, or phenylalkyl; and X.sup.1 and X.sup.2 are independently chosen from hydroxy or lower alkoxy; are inhibitors of angiotensin-converting enzyme and can be used for the treatment of hypertension in mammals.Type: GrantFiled: May 14, 1982Date of Patent: October 14, 1986Assignee: Mead Johnson & CompanyInventors: Tellis A. Martin, Terence M. Dolak
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Patent number: 4603209Abstract: The present invention discloses a new class of highly fluorescent indicator dyes that are specific for calcium ions. The new fluorescent indicator dyes combine a stilbene-type fluorophore with a tetracarboxylate parent Ca.sup.2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of EGTA and BAPTA. Preferred forms contain extra heterocyclic bridges to reinforce the ethylenic bond of the stilbene and to reduce hydrophobicity. Compared to their widely used predecessor, "quin2", the new dyes offer up to thirty-fold brighter fluorescence, major changes in wavelength (not just intensity) upon Ca.sup.2+ binding, slightly lower affinities for Ca.sup.2+, slightly longer wavelengths of excitation, and considerably improved selectivity for Ca.sup.2+ over other divalent cations. These properties, particularly the wavelength sensitivity to Ca.sup.2+, make the dyes useful indicators for many intracellular applications, especially in single cells, adherent cell layers, or bulk tissues.Type: GrantFiled: September 7, 1984Date of Patent: July 29, 1986Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Grzegorz Grynkiewicz
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Patent number: 4603217Abstract: A novel anti-inflammatory drug, which exhibits rapidly a pharmacological activity, maintains the activity for a long time, and is free from a side effect such as a gastrointestinal disorder or a central nervous disturbance is disclosed.The drug comprises a compound of an alkylcarbonyloxyalkylester or alkenylcarbonyloxyalkylester derivative of indolylacetic acid or anilinophenylacetic acid.The compound is prepared by an esterification reaction.Type: GrantFiled: July 25, 1984Date of Patent: July 29, 1986Assignee: Kaken Pharmaceutical Co., Ltd.Inventors: Katsuhiro Uchida, Mitsuo Mimura, Shozo Masumoto, Makoto Okumura, Masao Tohno, Misako Matsumura
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Patent number: 4568684Abstract: N-substituted 2-methylnaphthylamides of the general formula I ##STR1## where R is an unsubstituted or substituted furyl, isoxazolyl, oxazolyl, isothiazolyl, thiazolyl, 1,2,4-oxadiazol-3-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,2,5-thiadiazol-3-yl, 1,3,4-thiadiazol-2-yl or C.sub.1 -C.sub.5 -alkyl radical, or the group --CH.sub.2 --Y--R.sup.1, where Y is oxygen or sulfur and R.sup.1 is C.sub.1 -C.sub.6 -alkoxyethyl or C.sub.1 -C.sub.6 -alkoxyethoxyethyl, or R is C.sub.2 -C.sub.5 -alkenyl, C.sub.2 -C.sub.5 -alkynyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -alkoxycarbonyl or C.sub.3 -C.sub.7 -cycloalkyl, and fungicides containing these compounds.Type: GrantFiled: December 17, 1984Date of Patent: February 4, 1986Assignee: BASF AktiengesellschaftInventors: Costin Rentzea, Karl Eicken, Hans Theobald, Bernd Zeeh, Ernst-Heinrich Pommer, Eberhard Ammermann
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Patent number: 4560692Abstract: Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 and R.sub.2 may be either the same or different and each is hydrogen or lower alkyl;and wherein R.sup.3 and R.sup.4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R.sup.3 and R.sup.4 cannot both be hydrogen.These compounds are useful as anticonvulsant or anxiolytic agents.Type: GrantFiled: July 18, 1984Date of Patent: December 24, 1985Assignee: Hoffmann-La Roche Inc.Inventors: George F. Field, William J. Zally
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Patent number: 4550189Abstract: Soil repellents derived from fluorinated acrylates and aromatic amines are disclosed which have excellent durability and resistance to laundering. The compounds are represented by the formula(R).sub.m --Ar--(NHCH.sub.2 CH(R.sub.1)CO.sub.2 R.sub.f).sub.nwherein n is 1 to 3 and m is 0 to 4, Ar is an aromatic radical containing from 1 to 3 benzene rings which may be fused together or linked through a single carbon-carbon bond or a linking group, R.sub.f is a fluorinated radical, R.sub.1 is H or CH.sub.3, and R is independently selected from lower alkyl, lower alkoxy, halogen, hydroxy, nitro, cyano, amino, lower alkylamino, lower acylamino, --CO.sub.2 R.sub.3 and --NHCH.sub.2 CH(R.sub.1)CO.sub.2 R.sub.3 wherein R.sub.3 is lower alkyl, --CH.sub.2 CH.sub.2 OH, or --CH.sub.2 CH(OH)CH.sub.2 Cl. Also disclosed are polyester and nylon fibers having these compounds incorporated therein.Type: GrantFiled: February 1, 1985Date of Patent: October 29, 1985Assignee: American Hoechst CorporationInventors: Michael G. Kelly, James H. Covill
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Patent number: 4507497Abstract: Michler's ketone analogs and salts thereof, which are photosensitizers in water-soluble photoinitiator systems used to induce polymerization in free-radically-curable, ethylenically-unsaturated materials, are disclosed. The Michler's ketone analogs have the formula: ##STR1## wherein each R is an alkyl group of 1 to 8 carbon atoms,R.sup.1 is an alkylene group having 1 to 8 carbon atoms,Z is R.sup.1 COOH or R.sup.1 H, andn is an integer having a value of 1 or 2.The photoinitiator systems are useful in imaging systems.Type: GrantFiled: March 3, 1983Date of Patent: March 26, 1985Assignee: Minnesota Mining and Manufacturing CompanyInventor: Laurence W. Reilly, Jr.
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Patent number: 4476132Abstract: Quinolinone derivatives of the formula (I) ##STR1## in which X represents oxy or a direct bond, R.sub.1 represents an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical or hydrogen, Ph represents an optionally additionally substituted 1,2-phenylene radical containing the group R.sub.1 --X--C(O)--, and one of the radicals R.sub.2 and R.sub.3 represents an optionally esterified or amidated carboxy group R.sub.4 and the other represents hydrogen or an aliphatic radical or, in the case of a radical R.sub.3, hydroxy, and in which either R.sub.A and R.sub.B together represent oxo, R.sub.C and R.sub.D together represent an additional bond, or, when R.sub.2 represents a radical R.sub.4, R.sub.C is hydrogen and R.sub.3 and R.sub.D together represent oxo, and R.sub.E represents a radical R.sub.5 which represents hydrogen or an aliphatic, cycloaliphatic, araliphatic heterocyclic-aliphatic radical, or R.sub.A represents an optionally etherified hydroxy group and R.sub.Type: GrantFiled: March 19, 1982Date of Patent: October 9, 1984Assignee: Ciba-Geigy CorporationInventors: Richard Goschke, Pier G. Ferrini, Alfred Sallmann
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Patent number: 4450173Abstract: A short-acting .beta.-blocking compound of the formula ##STR1## wherein Ar may be substituted or unsubstituted aromatic, Y may be a straight or branched carbon chain or aralkyl, R may be lower alkyl, lower alkenyl, lower alkynyl, aryl or aralkyl, and x is an integer from 1 to about 3; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 21, 1982Date of Patent: May 22, 1984Assignee: American Hospital Supply CorporationInventors: Paul W. Erhardt, Robert J. Borgman
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Patent number: 4425357Abstract: Acyl anilines are disclosed having the formula ##STR1## wherein R and R.sup.1 (like or unlike each other)=H; CH.sub.3 ; C.sub.2 H.sub.5 ; n.C.sub.3 H.sub.7 ; --CH.sub.2 --CH.dbd.CH.sub.2 ; --CH.dbd.CH--CH.sub.3 ;R.sup.3 and R.sup.4 (like or unlike each other)=H; alkyl C.sub.1 -C.sub.3 ; halomethyl; Cl; F; CN; O-alkyl; S-alkyl; alkoxymethyl; orR.sup.3 and R.sup.4 together are (CH.sub.2 .dbd.) ##STR2## n=0,1 Z=phenyl optionally substituted; ##STR3## And R.sup.2 =H, CH.sub.3 ; m=1,2; Y=alkynyl C.sub.2 -C.sub.8 ; phenyl optionally substituted; phenyl-acetyl; furyl, thienyl; pyridyl; heterocyclic groups containing 2 or 3 heteroatoms, one of them different from nitrogen;R.sup.8 =CH.sub.3 ; alkoxymethyl; halomethyl; O-alkyl.The compounds of formula I are endowed with a high fungicidal activity and with a low phytotoxicity.Type: GrantFiled: May 8, 1981Date of Patent: January 10, 1984Assignee: Montedison S.p.A.Inventors: Enrico Bosone, Giovanni Camaggi, Lambertus de Vries, Carlo Garavaglia, Luigi Garlaschelli, Franco Gozzo, Jan C. Overeem, Simone Lorusso
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Patent number: 4328230Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, or an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain--COCH.dbd.C(COOH)NRh--,or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.Type: GrantFiled: March 5, 1979Date of Patent: May 4, 1982Assignee: Fisons LimitedInventors: Roger C. Brown, Hugh Cairns, Anthony R. Payne
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Patent number: 4304728Abstract: Compounds are described of the formula ##STR1## in which R.sup.1 is COOR.sup.5, CONHR.sup.5, cyano, 5-tetrazolyl or R.sup.6, where R.sup.5 is hydrogen or C.sub.1-8 alkyl and R.sup.6 is phenyl or naphthyl, the phenyl or naphthyl group being optionally substituted by one or more group selected from halogen, C.sub.1-6 alkyl, C.sub.1-4 alkoxy, hydroxy, benzyloxy, nitro, trifluoromethyl, carboxyl, C.sub.1-4 alkylsulphinyl, C.sub.1-4 alkylsulphonyl, N(R.sup.5).sub.2, NHCOR.sup.5 and SR.sup.5 ; R.sup.2 is R.sup.6 or --CH.dbd.CH--R.sup.6 when R.sup.1 is COOR.sup.5, CONHR.sup.5, cyano or 5-tetrazolyl, or R.sup.2 is --CH.dbd.CH--R.sup.6 when R.sup.1 is R.sup.6 ; R.sup.3 is hydrogen, C.sub.1-6 alkyl, halogen, hydroxy or --OCH.sub.2 R.sup.6 ; and R.sup.4 is hydrogen, C.sub.1-6 alkyl or halogen; and salts thereof. The compounds have pharmaceutical properties and in particular are useful in the treatment of immediate hypersensitivity conditions such as asthma.Type: GrantFiled: March 27, 1980Date of Patent: December 8, 1981Assignee: Lilly Industries LimitedInventors: Barry P. Clark, William J. Ross, Alec Todd
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Patent number: 4289777Abstract: Quinolonecarboxylic acid derivatives of the formula ##STR1## wherein the grouping ##STR2## is independently in the 6-, 7- or 8-position of each of the quinolone residues;m and n independently are each 1-4;R.sub.1 is hydrogen or alkyl of 1-6 carbon atoms;R.sub.2 is hyrogen, alkanoyl of 1-8 carbon atoms or benzoyl; andX is hydrogen, alkyl of 1-6 carbon atoms or the cation of a base which produces a physiologically acceptable salt with the quinolonecarboxylic acid,have valuable pharmacological properties.Type: GrantFiled: December 27, 1979Date of Patent: September 15, 1981Assignee: Schering, AktiengesellschaftInventors: Rudolf Albrecht, Eberhard Schroder, Irmgard Bottcher
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Patent number: 4287210Abstract: There are described acylaniline derivatives which in the phenyl ring are substituted in the meta-position with respect to the amino group by an aliphatic oxymethyl group or aryloxymethyl group, or by an aliphatic thiomethyl group or arylthiomethyl group. Compounds of this type have a very favorable microbicidal spectrum. They are used principally for combating phytopathogenic fungi and bacteria.Type: GrantFiled: November 21, 1979Date of Patent: September 1, 1981Assignee: Ciba-Geigy CorporationInventors: Wolfgang Eckhardt, Walter Kunz, Adolf Hubele
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Patent number: 4284755Abstract: N-Substituted aspartic acid monoesters of the formula ##STR1## wherein for example R.sub.1 is an alkyl group having 1 to 12 C atoms, a cyclohexyl, phenyl, tolyl or benzyl group, R.sub.2 is an alkyl group having 3 or 4 C atoms, or a cyclohexyl, phenyl, tolyl or methoxyphenyl group, and x is 2 or 3, are obtained by adding, by means of an addition reaction, to 1 mol of a maleic acid monoester of the formula ##STR2## 1 mol of an amine of the formulaH.sub.2 N--(CH.sub.2 ).sub.x NH--R.sub.2in the presence of a tertiary amine. The novel N-substituted aspartic acid monoesters are valuable curing agents for epoxide resins, and are particularly suitable for producing storage-stable B-stage resins.Type: GrantFiled: April 30, 1980Date of Patent: August 18, 1981Assignee: Ciba-Geigy CorporationInventors: Friedrich Lohse, Friedrich Stockinger, Sameer H. Eldin
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Patent number: 4281151Abstract: Compounds represented below ##STR1## and pharmaceutical compositions thereof, the compositions including the non-substituted phenylene dioxamates are useful in the prophylactic treatment of sensitized mammals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature.Type: GrantFiled: June 2, 1978Date of Patent: July 28, 1981Assignee: The Upjohn CompanyInventors: Charles M. Hall, John B. Wright
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Patent number: 4255587Abstract: Novel N-substituted 2,6-dialkylanilines and process for the preparation of N-substituted 2,6-dialkylanilines by reaction of 2,6-dialkylanilines with carbonyl compounds, followed by catalytic hydrogenation with hydrogen. The products are starting materials for the preparation of dyes and pesticides.Type: GrantFiled: January 10, 1979Date of Patent: March 10, 1981Assignee: BASF AktiengesellschaftInventors: Peter Plath, Wolfgang Rohr, Norbert Goetz
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Patent number: 4250314Abstract: Adducts of alkylphosphorous triamides with alpha, beta-unsaturated carbonyl compounds provide novel sulfur-free load-carrying additives for various organic compositions, e.g., lubricant oils.Type: GrantFiled: April 30, 1979Date of Patent: February 10, 1981Assignee: Mobil Oil CorporationInventor: Abraham O. Okorodudu
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Patent number: 4248886Abstract: N-oxalyl-N-phenyl-aminoacid or ester thereof of the formula ##STR1## in which: R.sup.1 represents hydrogen, alkyl or halogen,R.sup.2 represents hydrogen or alkyl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen, alkyl or optionally substituted phenyl,R.sup.5 represents hydrogen, alkyl, cyanoalkyl, alkenyl, alkynyl, halogenoalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, alkoxycarbonylalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, dialkylaminoalkyl, optionally substituted aryl or optionally substituted aralkyl andR.sup.6 represents alkyl, cyanoalkyl, alkenyl, alkynyl, halogenoalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, alkoxycarbonylalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, dialkylaminoalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aroxyalkyl, epoxyalkyl or a grouping of the formula ##STR2## wherein R.sup.7, R.sup.8 and R.sup.Type: GrantFiled: July 31, 1979Date of Patent: February 3, 1981Assignee: Bayer AktiengesellschaftInventors: Winfried Lunkenheimer, Wilhelm Brandes
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Patent number: 4246429Abstract: Novel .alpha.-amino-phenylacetic acid derivatives, said phenyl having at least one substituent other than hydrogen, are useful as herbicidal, algicidal and plant growth regulatng agents.Type: GrantFiled: April 9, 1979Date of Patent: January 20, 1981Assignee: Janssen Pharmaceutica, N.V.Inventor: Georges Van Daele
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Patent number: 4243606Abstract: The present invention relates to new N-substituted anilines which correspond to the general formula: ##STR1## in which R.sub.1 represents an alkyl radical or substituted alkyl radical, R.sub.2 represents a hydrogen atom, an alkyl radical or substituted alkyl radical, R.sub.3 represents a cyano, carbamoyl, carboxy or carbalkoxy radical and R.sub.4 represents a hydrogen or halogen atom or an alkyl or alkoxy radical. These compounds are valuable intermediates for the preparation of coloring materials, especially as coupling compounds for the synthesis of azo dyes.Type: GrantFiled: September 30, 1977Date of Patent: January 6, 1981Assignee: Produits Chimiques Ugine KuhlmannInventors: Paul M. C. Bourdauducq, Claude M. H. E. Brouard, Claude L. E. Moerel, Jean-Pierre H. Stiot
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Patent number: 4231953Abstract: Fluoro substituted aryl esters and thiolesters of amino acids, intermediates therefor, synthesis thereof and the use of said esters and thiolesters and compositions for the control of pests.Type: GrantFiled: June 4, 1979Date of Patent: November 4, 1980Assignee: Zoecon CorporationInventors: Clive A. Henrick, Barbara A. Garcia
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Patent number: 4230628Abstract: This disclosure describes novel 4-[(carboxyl- and sulfamyl-substituted alkyl)amino]benzoic acids and analogs which are useful as hypolipidemic and antiatherosclerotic agents.Type: GrantFiled: April 12, 1978Date of Patent: October 28, 1980Assignee: American Cyanamid CompanyInventor: Robert G. Shepherd
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Patent number: 4162331Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: January 24, 1977Date of Patent: July 24, 1979Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4156726Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.Type: GrantFiled: November 26, 1975Date of Patent: May 29, 1979Assignee: Fisons LimitedInventors: Roger C. Brown, Hugh Cairns, Anthony R. Payne
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Patent number: 4128570Abstract: A method of treating mammals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature which comprises administering prophylactically to said mammal an anti-allergy or anaphylactic reaction effective amount of a compound of the formula ##STR1## Novel compounds and compositions are also claimed.Type: GrantFiled: October 6, 1977Date of Patent: December 5, 1978Assignee: The Upjohn CompanyInventors: Charles M. Hall, John B. Wright
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Patent number: 4126619Abstract: New crosslinkable bis-imidyl derivatives are described which can be produced by reaction of imidylphthalic acid derivatives, such as maleimidyl-phthalic acid anhydrides, with monomeric, oligomeric or polymeric diamines. The new crosslinkable bis-imidyl derivatives can be used for producing crosslinked polymers which are distinguished, in particular, by their stability to oxidation and to heat.Type: GrantFiled: December 6, 1976Date of Patent: November 21, 1978Assignee: Ciba-Geigy CorporationInventors: Roland Darms, Vratislav Kvita, Gerd Greber