Polycarboxylic Acid Patents (Class 560/44)
  • Patent number: 5075491
    Abstract: A composition useful for incorporation into polymer compositions employed for food packaging or the like comprising a bis- or tris-methine compound having the structural formula ##STR1## wherein A is selected from the radicals ##STR2## wherein R' and R" are each selected from chlorine, bromine, fluorine, alkyl, alkoxy, aryl, aryloxy and arylthio;each n is independently 0, 1, 2;R.sub.1 is selected from a large variety of radicals such as cycloalkyl, phenyl, and straight or branched alkyl which may be substituted;R.sub.2 is alkylene or the like;R.sub.3, R.sub.4, and R.sub.5 are each selected from hydrogen and alkyl; andP and Q and P.sup.1 and Q.sup.1 are selected from cyano, carbalkoxy, carbaryloxy, carbaralkyloxy, or the like.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: December 24, 1991
    Assignee: Eastman Kodak Company
    Inventors: Max A. Weaver, Wayne P. Pruett, Samuel D. Hilbert
  • Patent number: 5066823
    Abstract: A process for the preparation of 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives of formula (I), wherein X is I or Br, R is H or a variously substituted alkyl, or a group of formula (II), wherein X has the above meanings; Y is hydroxy, alkoxy, hydroxyalkoxy, alkylamino or hydroxyalkylamino; Z may be the same as COY or it is hydroxylalkylaminocarbonyl provided that at least one of the two acyl or R groups is hydroxy-substituted, which process comprises the rearrangement of the corresponding 5-(alkylaminocarbonyl-alkoxy)-2,4,6-trioodo ro tribromo-benzoic acid derivatives, in the presence of bases.
    Type: Grant
    Filed: October 10, 1989
    Date of Patent: November 19, 1991
    Assignee: Bracco Industria Chemica S.p.A.
    Inventors: Ernest Felder, Carlo Musu, Luciano Fumagalli, Fulvio Uggeri
  • Patent number: 5066824
    Abstract: The present invention is directed to a process for preparing amine terminated compounds by reacting a polyfunctional acetoacetic acid ester with either ammonia or an organic compound which contains one or more primary amino groups in the presence of a solvent and an acidic catalyst selected from the group consisting of (i) boron trifuloride etherate and (ii) organic acids having pKa values of from 0.1 to 0.8 with the proviso that if the primary amino group containing compound contains no aromatically bound amino groups, the pKa of said organic acid is from 0.1 to less than 0.7.
    Type: Grant
    Filed: August 3, 1990
    Date of Patent: November 19, 1991
    Assignee: Mobay Corporation
    Inventors: Robson Mafoti, Josef Sanders
  • Patent number: 5036104
    Abstract: 2-Acylaminoalkyl-3-[1-(carboxycycloalkylcarbamoyl)cycloalkyl]propanoic acid derivatives (which may also be viewed as glutaramide derivatives) are useful in the treatment of hypertension, heart failure and renal insufficiency, based upon their inhibition of zinc-dependent, neutral endopiptidase.
    Type: Grant
    Filed: June 14, 1990
    Date of Patent: July 30, 1991
    Assignee: Pfizer Inc.
    Inventors: John C. Danilewicz, Keith James
  • Patent number: 5001254
    Abstract: The present invention relates to novel methods for the preparation of quinoline-2,3-dicarboxylic acid, useful for the preparation of the highly effective 2-(2-imidazolin-2-yl)quinoline-3-carboxylic acid herbicidal agents.
    Type: Grant
    Filed: May 19, 1988
    Date of Patent: March 19, 1991
    Inventor: Donald R. Maulding
  • Patent number: 4996350
    Abstract: The present invention relates to an improved method for the preparation of dialkyl dichlorosuccinates by chlorination of a dialkyl maleate in the presence of a catalytic amount of a C.sub.1 -C.sub.4 alkyl alcohol in the absence of a solvent which are useful intermediates in the preparation of anilinofumarates. Anilinofumarates are, in turn, used in the preparation of 2-(2-imidazolin-2-yl)quinoline-3-carboxylic acid herbicidal agents.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: February 26, 1991
    Assignee: American Cyanamid Company
    Inventor: Albert A. Cevasco
  • Patent number: 4981997
    Abstract: A process for the preparation of 2,5-diarylaminoterephthalic acids by oxidation of 2,5-diarylamino-3,6-dihydroterephthalic acid esters using oxygen or oxygen-containing gases, preferably air, in alcoholic-alkaline or alcoholic-aqueous-alkaline solution or suspension in the presence of an oxygen-transferring agent and working up to give the 2,5-diarylaminoterephthalic acids, characterized in that the oxidation is carried out in the presence of quaternary ammonium compound.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: January 1, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Detlef-Ingo Schutze, Reinold Schmitz
  • Patent number: 4958043
    Abstract: A composition useful for incorporation into polymer compositions employed for food packaging or the like comprising a bis- or tris-methine compound having the structural formula ##STR1## wherein A is selected from the radicals ##STR2## wherein R' and R" are each selected from chlorine, bromine, fluorine, alkyl, alkoxy, aryl, aryloxy and arylthio;each n is independently 0, 1, 2;R.sub.1 is selected from a large variety of radicals such as cycloalkyl, phenyl, and straight or branched alkyl which may be substituted;R.sub.2 is alkylene or the like;R.sub.3, R.sub.4, and R.sub.5 are each selected from hydrogen and alkyl; andP and Q and P.sup.1 and Q.sup.1 are selected from cyano, carbalkoxy, carbaryloxy, carbaralkyloxy, or the like.The invention compositions are especially useful in combination with molding or fiber-grade condensation polymer; most preferably such polymer having copolymerized therein a total of from 1.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: September 18, 1990
    Assignee: Eastman Kodak Company
    Inventors: Max A. Weaver, Wayne P. Pruett, Samuel D. Hilbert
  • Patent number: 4910327
    Abstract: There are provided novel alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid; novel dialkyl 3-(substituted)phenylaminobut-2-ene-dioates, useful as intermediates for the preparation of highly effective 2-(2-imidazolin-2-yl)quinoline herbicidal agents and methods for the preparation thereof.
    Type: Grant
    Filed: March 27, 1989
    Date of Patent: March 20, 1990
    Assignee: American Cyanamid Company
    Inventor: Robert F. Doehner, Jr.
  • Patent number: 4906662
    Abstract: Disclosed are phenol derivatives of the formula ##STR1## wherein R.sup.1 is a substituted phenyl group, R.sup.2 and R.sup.3 are C.sub.1 -C.sub.6 alkyl group and of the formula ##STR2## wherein R.sup.8, R.sup.9 and R.sup.10 are C.sub.1 -C.sub.6 alkyl and the like and A is H, C.sub.1 -C.sub.6 alkylsulfonyl and the like substituents. These compounds and some related compounds have anti-inflammatory activity and lipoxygenase inhibitory activity.
    Type: Grant
    Filed: January 27, 1987
    Date of Patent: March 6, 1990
    Assignee: Otsuka Pharmaceutical Factory, Inc.
    Inventors: Kinji Hashimoto, Kiyoto Goto, Ken-ichi Kanai, Yoshiaki Tsuda
  • Patent number: 4904816
    Abstract: There is provided a novel process for the manufacture of anilinofumarate via chloromaleate or chlorofumarate or mixtures thereof.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: February 27, 1990
    Assignee: American Cyanamid Company
    Inventors: Albert A. Cevasco, Donald Roy
  • Patent number: 4889855
    Abstract: Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein --A-- together with the two carbon atoms denoted as 1 and 2 is selected from ##STR2## R.sup.1, R.sup.2 and R.sup.3 are independently H, halogen, CN, NH.sub.2, NO.sub.2, SO.sub.3 H, SO.sub.2 NH.sub.2, or CONH.sub.2The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use.The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: December 26, 1989
    Assignee: A/S Ferrosan
    Inventors: Poul Jacobsen, Flemming E. Nielsen, Tage Honore
  • Patent number: 4889947
    Abstract: Sunscreen compositions are described which contain certain substituted naphthalenylidenes which act as UV filters when incorporated in a carrier in amounts ranging from 0.1-50% by weight.
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: December 26, 1989
    Assignee: ICI Americas Inc.
    Inventors: Charalambos J. Phalangas, Thomas P. Cleary
  • Patent number: 4855504
    Abstract: High molecular weight amines having reduced low molecular weight amine contents are obtained by reacting a mixture of (1) a high molecular weight amine and (2) a low molecular weight amine with (3) an isocyanate in quantities such that from 0.5 to 10 equivalents of isocyanate are present for each equivalent of low molecular weight amine. The product of high molecular weight amines is particularly useful in the production of isocyanate addition products such as polyurethane plastics and foams.
    Type: Grant
    Filed: September 23, 1985
    Date of Patent: August 8, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Werner Rasshofer, Ernst Grigat, Gerhard Grogler, Heinrich Hess, Richard Kopp
  • Patent number: 4847405
    Abstract: The present invention relates to novel methods for the preparation of anilinofumarate [quinoline- 2,3-dicarboxylic acid], a useful intermediate in the preparation of 2-(2-imidazolin-2-yl)-quinoline-3-carboxylic acid herbicidal agents.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: July 11, 1989
    Assignee: American Cyanamid Company
    Inventor: Donald R. Maulding
  • Patent number: 4843162
    Abstract: There are provided novel alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid; novel dialkyl 3-(substituted)phenylamino-2-ene-dioates, useful as intermediates for the preparation of highly effective 2-(2-imidazolin-2-yl)quinoline herbicidal agents and methods for the preparation thereof.
    Type: Grant
    Filed: February 21, 1987
    Date of Patent: June 27, 1989
    Assignee: American Cyanamid Company
    Inventor: Robert F. Doehner, Jr.
  • Patent number: 4837353
    Abstract: 2-(N-Phenylakyl-N-formyl)amino-3-hydroxy-2-propenoic acids are intermediates for mercaptoimidazolecarboxylic acids which are dopamine-.beta.-hydroxylase inhibitors.
    Type: Grant
    Filed: January 21, 1988
    Date of Patent: June 6, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Joseph A. Finkelstein, Lawrence I. Kruse, Thomas B. Leonard
  • Patent number: 4824995
    Abstract: A poly-p-phenylamino carboxylate having the following structure: ##STR1## wherein n is greater than 1; R is a C.sub.1 to C.sub.6 alkyl group; and R.sub.1 and R.sub.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: April 25, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Neville E. Drysdale
  • Patent number: 4814486
    Abstract: The present invention relates to an improved method for the preparation of anilinofumarates useful as intermediates in the preparation of 2-(2-imidazolin-2-yl) quinoline-3-carboxylic acid herbicidal agents.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: March 21, 1989
    Assignee: American Cyanamid Company
    Inventors: Donald R. Maulding, Albert A. Cevasco
  • Patent number: 4738787
    Abstract: The present application relates to cationic block polyesters useful as soil relese agents, softeners and antistatic agents. In addition to cleaning performance, laundry detergent compositions should have other benefits. One is the ability to impart soil release properties to fabrics woven from polyester fibers.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: April 19, 1988
    Assignee: Alkaril Chemicals Inc.
    Inventors: Anthony J. O'Lenick, Jr., Joseph J. Fanelli
  • Patent number: 4716178
    Abstract: Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a group which includes carboxyl, tetrazolyl or N-methyltetrazolyl are useful as inhibitors of leukotriene synthesis and as antiallergic agents. Pharmaceutical compositions containing such compounds and pharmacological methods for use of such compounds are also disclosed.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: December 29, 1987
    Assignee: Riker Laboratories, Inc.
    Inventors: Robert A. Scherrer, Mark A. Rustad
  • Patent number: 4675432
    Abstract: The present invention relates to methods for the preparation of anilinofumarate, a useful intermediate in the preparation of quinoline-2,3-dicarboxylic acid and in the preparation of 2-(2-imidazolin-z-yl) quinoline-3-carboxylic acid herbicidal agents.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: June 23, 1987
    Assignee: American Cyanamid Company
    Inventor: Donald R. Maulding
  • Patent number: 4656283
    Abstract: There are provided novel alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid; novel dialkyl 3-(substituted)phenylaminobut-2-ene-dioates, useful as intermediates for the preparation of highly effective 2-(2-imidazolin-2-yl)quinoline herbicidal agents and methods for the preparation thereof.
    Type: Grant
    Filed: February 4, 1985
    Date of Patent: April 7, 1987
    Assignee: American Cyanamid Company
    Inventor: Robert F. Doehner, Jr.
  • Patent number: 4617291
    Abstract: Dipeptides having the formula ##STR1## wherein A is halogen, hydrogen, lower alkyl, or lower alkoxy; B is hydrogen or lower alkyl, or A and B are taken together to form an ortho-methylene or ethylene bridge; R is hydrogen, lower alkyl, or phenylalkyl; and X.sup.1 and X.sup.2 are independently chosen from hydroxy or lower alkoxy; are inhibitors of angiotensin-converting enzyme and can be used for the treatment of hypertension in mammals.
    Type: Grant
    Filed: May 14, 1982
    Date of Patent: October 14, 1986
    Assignee: Mead Johnson & Company
    Inventors: Tellis A. Martin, Terence M. Dolak
  • Patent number: 4603209
    Abstract: The present invention discloses a new class of highly fluorescent indicator dyes that are specific for calcium ions. The new fluorescent indicator dyes combine a stilbene-type fluorophore with a tetracarboxylate parent Ca.sup.2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of EGTA and BAPTA. Preferred forms contain extra heterocyclic bridges to reinforce the ethylenic bond of the stilbene and to reduce hydrophobicity. Compared to their widely used predecessor, "quin2", the new dyes offer up to thirty-fold brighter fluorescence, major changes in wavelength (not just intensity) upon Ca.sup.2+ binding, slightly lower affinities for Ca.sup.2+, slightly longer wavelengths of excitation, and considerably improved selectivity for Ca.sup.2+ over other divalent cations. These properties, particularly the wavelength sensitivity to Ca.sup.2+, make the dyes useful indicators for many intracellular applications, especially in single cells, adherent cell layers, or bulk tissues.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: July 29, 1986
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Grzegorz Grynkiewicz
  • Patent number: 4603217
    Abstract: A novel anti-inflammatory drug, which exhibits rapidly a pharmacological activity, maintains the activity for a long time, and is free from a side effect such as a gastrointestinal disorder or a central nervous disturbance is disclosed.The drug comprises a compound of an alkylcarbonyloxyalkylester or alkenylcarbonyloxyalkylester derivative of indolylacetic acid or anilinophenylacetic acid.The compound is prepared by an esterification reaction.
    Type: Grant
    Filed: July 25, 1984
    Date of Patent: July 29, 1986
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Katsuhiro Uchida, Mitsuo Mimura, Shozo Masumoto, Makoto Okumura, Masao Tohno, Misako Matsumura
  • Patent number: 4568684
    Abstract: N-substituted 2-methylnaphthylamides of the general formula I ##STR1## where R is an unsubstituted or substituted furyl, isoxazolyl, oxazolyl, isothiazolyl, thiazolyl, 1,2,4-oxadiazol-3-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,2,5-thiadiazol-3-yl, 1,3,4-thiadiazol-2-yl or C.sub.1 -C.sub.5 -alkyl radical, or the group --CH.sub.2 --Y--R.sup.1, where Y is oxygen or sulfur and R.sup.1 is C.sub.1 -C.sub.6 -alkoxyethyl or C.sub.1 -C.sub.6 -alkoxyethoxyethyl, or R is C.sub.2 -C.sub.5 -alkenyl, C.sub.2 -C.sub.5 -alkynyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -alkoxycarbonyl or C.sub.3 -C.sub.7 -cycloalkyl, and fungicides containing these compounds.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: February 4, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Costin Rentzea, Karl Eicken, Hans Theobald, Bernd Zeeh, Ernst-Heinrich Pommer, Eberhard Ammermann
  • Patent number: 4560692
    Abstract: Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 and R.sub.2 may be either the same or different and each is hydrogen or lower alkyl;and wherein R.sup.3 and R.sup.4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R.sup.3 and R.sup.4 cannot both be hydrogen.These compounds are useful as anticonvulsant or anxiolytic agents.
    Type: Grant
    Filed: July 18, 1984
    Date of Patent: December 24, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: George F. Field, William J. Zally
  • Patent number: 4550189
    Abstract: Soil repellents derived from fluorinated acrylates and aromatic amines are disclosed which have excellent durability and resistance to laundering. The compounds are represented by the formula(R).sub.m --Ar--(NHCH.sub.2 CH(R.sub.1)CO.sub.2 R.sub.f).sub.nwherein n is 1 to 3 and m is 0 to 4, Ar is an aromatic radical containing from 1 to 3 benzene rings which may be fused together or linked through a single carbon-carbon bond or a linking group, R.sub.f is a fluorinated radical, R.sub.1 is H or CH.sub.3, and R is independently selected from lower alkyl, lower alkoxy, halogen, hydroxy, nitro, cyano, amino, lower alkylamino, lower acylamino, --CO.sub.2 R.sub.3 and --NHCH.sub.2 CH(R.sub.1)CO.sub.2 R.sub.3 wherein R.sub.3 is lower alkyl, --CH.sub.2 CH.sub.2 OH, or --CH.sub.2 CH(OH)CH.sub.2 Cl. Also disclosed are polyester and nylon fibers having these compounds incorporated therein.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: October 29, 1985
    Assignee: American Hoechst Corporation
    Inventors: Michael G. Kelly, James H. Covill
  • Patent number: 4507497
    Abstract: Michler's ketone analogs and salts thereof, which are photosensitizers in water-soluble photoinitiator systems used to induce polymerization in free-radically-curable, ethylenically-unsaturated materials, are disclosed. The Michler's ketone analogs have the formula: ##STR1## wherein each R is an alkyl group of 1 to 8 carbon atoms,R.sup.1 is an alkylene group having 1 to 8 carbon atoms,Z is R.sup.1 COOH or R.sup.1 H, andn is an integer having a value of 1 or 2.The photoinitiator systems are useful in imaging systems.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: March 26, 1985
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Laurence W. Reilly, Jr.
  • Patent number: 4476132
    Abstract: Quinolinone derivatives of the formula (I) ##STR1## in which X represents oxy or a direct bond, R.sub.1 represents an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical or hydrogen, Ph represents an optionally additionally substituted 1,2-phenylene radical containing the group R.sub.1 --X--C(O)--, and one of the radicals R.sub.2 and R.sub.3 represents an optionally esterified or amidated carboxy group R.sub.4 and the other represents hydrogen or an aliphatic radical or, in the case of a radical R.sub.3, hydroxy, and in which either R.sub.A and R.sub.B together represent oxo, R.sub.C and R.sub.D together represent an additional bond, or, when R.sub.2 represents a radical R.sub.4, R.sub.C is hydrogen and R.sub.3 and R.sub.D together represent oxo, and R.sub.E represents a radical R.sub.5 which represents hydrogen or an aliphatic, cycloaliphatic, araliphatic heterocyclic-aliphatic radical, or R.sub.A represents an optionally etherified hydroxy group and R.sub.
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: October 9, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Richard Goschke, Pier G. Ferrini, Alfred Sallmann
  • Patent number: 4450173
    Abstract: A short-acting .beta.-blocking compound of the formula ##STR1## wherein Ar may be substituted or unsubstituted aromatic, Y may be a straight or branched carbon chain or aralkyl, R may be lower alkyl, lower alkenyl, lower alkynyl, aryl or aralkyl, and x is an integer from 1 to about 3; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: May 22, 1984
    Assignee: American Hospital Supply Corporation
    Inventors: Paul W. Erhardt, Robert J. Borgman
  • Patent number: 4425357
    Abstract: Acyl anilines are disclosed having the formula ##STR1## wherein R and R.sup.1 (like or unlike each other)=H; CH.sub.3 ; C.sub.2 H.sub.5 ; n.C.sub.3 H.sub.7 ; --CH.sub.2 --CH.dbd.CH.sub.2 ; --CH.dbd.CH--CH.sub.3 ;R.sup.3 and R.sup.4 (like or unlike each other)=H; alkyl C.sub.1 -C.sub.3 ; halomethyl; Cl; F; CN; O-alkyl; S-alkyl; alkoxymethyl; orR.sup.3 and R.sup.4 together are (CH.sub.2 .dbd.) ##STR2## n=0,1 Z=phenyl optionally substituted; ##STR3## And R.sup.2 =H, CH.sub.3 ; m=1,2; Y=alkynyl C.sub.2 -C.sub.8 ; phenyl optionally substituted; phenyl-acetyl; furyl, thienyl; pyridyl; heterocyclic groups containing 2 or 3 heteroatoms, one of them different from nitrogen;R.sup.8 =CH.sub.3 ; alkoxymethyl; halomethyl; O-alkyl.The compounds of formula I are endowed with a high fungicidal activity and with a low phytotoxicity.
    Type: Grant
    Filed: May 8, 1981
    Date of Patent: January 10, 1984
    Assignee: Montedison S.p.A.
    Inventors: Enrico Bosone, Giovanni Camaggi, Lambertus de Vries, Carlo Garavaglia, Luigi Garlaschelli, Franco Gozzo, Jan C. Overeem, Simone Lorusso
  • Patent number: 4328230
    Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, or an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain--COCH.dbd.C(COOH)NRh--,or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: May 4, 1982
    Assignee: Fisons Limited
    Inventors: Roger C. Brown, Hugh Cairns, Anthony R. Payne
  • Patent number: 4304728
    Abstract: Compounds are described of the formula ##STR1## in which R.sup.1 is COOR.sup.5, CONHR.sup.5, cyano, 5-tetrazolyl or R.sup.6, where R.sup.5 is hydrogen or C.sub.1-8 alkyl and R.sup.6 is phenyl or naphthyl, the phenyl or naphthyl group being optionally substituted by one or more group selected from halogen, C.sub.1-6 alkyl, C.sub.1-4 alkoxy, hydroxy, benzyloxy, nitro, trifluoromethyl, carboxyl, C.sub.1-4 alkylsulphinyl, C.sub.1-4 alkylsulphonyl, N(R.sup.5).sub.2, NHCOR.sup.5 and SR.sup.5 ; R.sup.2 is R.sup.6 or --CH.dbd.CH--R.sup.6 when R.sup.1 is COOR.sup.5, CONHR.sup.5, cyano or 5-tetrazolyl, or R.sup.2 is --CH.dbd.CH--R.sup.6 when R.sup.1 is R.sup.6 ; R.sup.3 is hydrogen, C.sub.1-6 alkyl, halogen, hydroxy or --OCH.sub.2 R.sup.6 ; and R.sup.4 is hydrogen, C.sub.1-6 alkyl or halogen; and salts thereof. The compounds have pharmaceutical properties and in particular are useful in the treatment of immediate hypersensitivity conditions such as asthma.
    Type: Grant
    Filed: March 27, 1980
    Date of Patent: December 8, 1981
    Assignee: Lilly Industries Limited
    Inventors: Barry P. Clark, William J. Ross, Alec Todd
  • Patent number: 4289777
    Abstract: Quinolonecarboxylic acid derivatives of the formula ##STR1## wherein the grouping ##STR2## is independently in the 6-, 7- or 8-position of each of the quinolone residues;m and n independently are each 1-4;R.sub.1 is hydrogen or alkyl of 1-6 carbon atoms;R.sub.2 is hyrogen, alkanoyl of 1-8 carbon atoms or benzoyl; andX is hydrogen, alkyl of 1-6 carbon atoms or the cation of a base which produces a physiologically acceptable salt with the quinolonecarboxylic acid,have valuable pharmacological properties.
    Type: Grant
    Filed: December 27, 1979
    Date of Patent: September 15, 1981
    Assignee: Schering, Aktiengesellschaft
    Inventors: Rudolf Albrecht, Eberhard Schroder, Irmgard Bottcher
  • Patent number: 4287210
    Abstract: There are described acylaniline derivatives which in the phenyl ring are substituted in the meta-position with respect to the amino group by an aliphatic oxymethyl group or aryloxymethyl group, or by an aliphatic thiomethyl group or arylthiomethyl group. Compounds of this type have a very favorable microbicidal spectrum. They are used principally for combating phytopathogenic fungi and bacteria.
    Type: Grant
    Filed: November 21, 1979
    Date of Patent: September 1, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Wolfgang Eckhardt, Walter Kunz, Adolf Hubele
  • Patent number: 4284755
    Abstract: N-Substituted aspartic acid monoesters of the formula ##STR1## wherein for example R.sub.1 is an alkyl group having 1 to 12 C atoms, a cyclohexyl, phenyl, tolyl or benzyl group, R.sub.2 is an alkyl group having 3 or 4 C atoms, or a cyclohexyl, phenyl, tolyl or methoxyphenyl group, and x is 2 or 3, are obtained by adding, by means of an addition reaction, to 1 mol of a maleic acid monoester of the formula ##STR2## 1 mol of an amine of the formulaH.sub.2 N--(CH.sub.2 ).sub.x NH--R.sub.2in the presence of a tertiary amine. The novel N-substituted aspartic acid monoesters are valuable curing agents for epoxide resins, and are particularly suitable for producing storage-stable B-stage resins.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: August 18, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Friedrich Lohse, Friedrich Stockinger, Sameer H. Eldin
  • Patent number: 4281151
    Abstract: Compounds represented below ##STR1## and pharmaceutical compositions thereof, the compositions including the non-substituted phenylene dioxamates are useful in the prophylactic treatment of sensitized mammals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature.
    Type: Grant
    Filed: June 2, 1978
    Date of Patent: July 28, 1981
    Assignee: The Upjohn Company
    Inventors: Charles M. Hall, John B. Wright
  • Patent number: 4255587
    Abstract: Novel N-substituted 2,6-dialkylanilines and process for the preparation of N-substituted 2,6-dialkylanilines by reaction of 2,6-dialkylanilines with carbonyl compounds, followed by catalytic hydrogenation with hydrogen. The products are starting materials for the preparation of dyes and pesticides.
    Type: Grant
    Filed: January 10, 1979
    Date of Patent: March 10, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Plath, Wolfgang Rohr, Norbert Goetz
  • Patent number: 4250314
    Abstract: Adducts of alkylphosphorous triamides with alpha, beta-unsaturated carbonyl compounds provide novel sulfur-free load-carrying additives for various organic compositions, e.g., lubricant oils.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: February 10, 1981
    Assignee: Mobil Oil Corporation
    Inventor: Abraham O. Okorodudu
  • Patent number: 4248886
    Abstract: N-oxalyl-N-phenyl-aminoacid or ester thereof of the formula ##STR1## in which: R.sup.1 represents hydrogen, alkyl or halogen,R.sup.2 represents hydrogen or alkyl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen, alkyl or optionally substituted phenyl,R.sup.5 represents hydrogen, alkyl, cyanoalkyl, alkenyl, alkynyl, halogenoalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, alkoxycarbonylalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, dialkylaminoalkyl, optionally substituted aryl or optionally substituted aralkyl andR.sup.6 represents alkyl, cyanoalkyl, alkenyl, alkynyl, halogenoalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, alkoxycarbonylalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, dialkylaminoalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aroxyalkyl, epoxyalkyl or a grouping of the formula ##STR2## wherein R.sup.7, R.sup.8 and R.sup.
    Type: Grant
    Filed: July 31, 1979
    Date of Patent: February 3, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Winfried Lunkenheimer, Wilhelm Brandes
  • Patent number: 4246429
    Abstract: Novel .alpha.-amino-phenylacetic acid derivatives, said phenyl having at least one substituent other than hydrogen, are useful as herbicidal, algicidal and plant growth regulatng agents.
    Type: Grant
    Filed: April 9, 1979
    Date of Patent: January 20, 1981
    Assignee: Janssen Pharmaceutica, N.V.
    Inventor: Georges Van Daele
  • Patent number: 4243606
    Abstract: The present invention relates to new N-substituted anilines which correspond to the general formula: ##STR1## in which R.sub.1 represents an alkyl radical or substituted alkyl radical, R.sub.2 represents a hydrogen atom, an alkyl radical or substituted alkyl radical, R.sub.3 represents a cyano, carbamoyl, carboxy or carbalkoxy radical and R.sub.4 represents a hydrogen or halogen atom or an alkyl or alkoxy radical. These compounds are valuable intermediates for the preparation of coloring materials, especially as coupling compounds for the synthesis of azo dyes.
    Type: Grant
    Filed: September 30, 1977
    Date of Patent: January 6, 1981
    Assignee: Produits Chimiques Ugine Kuhlmann
    Inventors: Paul M. C. Bourdauducq, Claude M. H. E. Brouard, Claude L. E. Moerel, Jean-Pierre H. Stiot
  • Patent number: 4231953
    Abstract: Fluoro substituted aryl esters and thiolesters of amino acids, intermediates therefor, synthesis thereof and the use of said esters and thiolesters and compositions for the control of pests.
    Type: Grant
    Filed: June 4, 1979
    Date of Patent: November 4, 1980
    Assignee: Zoecon Corporation
    Inventors: Clive A. Henrick, Barbara A. Garcia
  • Patent number: 4230628
    Abstract: This disclosure describes novel 4-[(carboxyl- and sulfamyl-substituted alkyl)amino]benzoic acids and analogs which are useful as hypolipidemic and antiatherosclerotic agents.
    Type: Grant
    Filed: April 12, 1978
    Date of Patent: October 28, 1980
    Assignee: American Cyanamid Company
    Inventor: Robert G. Shepherd
  • Patent number: 4162331
    Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.
    Type: Grant
    Filed: January 24, 1977
    Date of Patent: July 24, 1979
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
  • Patent number: 4156726
    Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
    Type: Grant
    Filed: November 26, 1975
    Date of Patent: May 29, 1979
    Assignee: Fisons Limited
    Inventors: Roger C. Brown, Hugh Cairns, Anthony R. Payne
  • Patent number: 4128570
    Abstract: A method of treating mammals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature which comprises administering prophylactically to said mammal an anti-allergy or anaphylactic reaction effective amount of a compound of the formula ##STR1## Novel compounds and compositions are also claimed.
    Type: Grant
    Filed: October 6, 1977
    Date of Patent: December 5, 1978
    Assignee: The Upjohn Company
    Inventors: Charles M. Hall, John B. Wright
  • Patent number: 4126619
    Abstract: New crosslinkable bis-imidyl derivatives are described which can be produced by reaction of imidylphthalic acid derivatives, such as maleimidyl-phthalic acid anhydrides, with monomeric, oligomeric or polymeric diamines. The new crosslinkable bis-imidyl derivatives can be used for producing crosslinked polymers which are distinguished, in particular, by their stability to oxidation and to heat.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: November 21, 1978
    Assignee: Ciba-Geigy Corporation
    Inventors: Roland Darms, Vratislav Kvita, Gerd Greber