Polyphenolic Hydroxy Or Metallate Patents (Class 560/70)
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Patent number: 5142096Abstract: KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.Type: GrantFiled: March 27, 1989Date of Patent: August 25, 1992Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kazutoshi Kuroda, Hiroshi Kase, Katsuhiko Ando, Isao Kawamoto, Toru Yasuzawa, Hiroshi Sano, Joji Goto, Koji Yamada
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Patent number: 5130454Abstract: Polytetrahydrofuran derivatives of the general formula ##STR1## where n is from 2 to 70, X is the bridge member --NH-- or --O-- and R.sup.1 and R.sup.4 are each hydrogen or various radicals.Type: GrantFiled: December 19, 1990Date of Patent: July 14, 1992Assignee: BASF AktiengesellschaftInventors: Eckhard Hickmann, Ulrich Koehler, Hardo Siegel
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Patent number: 5025036Abstract: The invention relates to catechol carboxylic acid derivatives of the formula ##STR1## wherein, R.sub.1 is ##STR2## acetyl, hydrogen, hydroxy or alkanoyloxy, R.sub.2 is ##STR3## hydroxy, hydrogen or alkanoyloxy, wherein R is hydrogen, lower alkyl or --(CH.sub.2).sub.n --N--(lower alkyl).sub.2,R.sub.3 is hydrogen, lower alkyl or amino,R.sub.4 is hydrogen, lower alkyl, halogen or aminoA is ##STR4## wherein, R.sub.5 is hydrogen or acyl, R.sub.6 is hydrogen, halogen, lower alkyl, aryl or cycloalkyl, and R.sub.7 and R.sub.8, independently, are hydrogen, lower alkyl or halogen, orA is ##STR5## wherein, R.sub.5 is hydrogen or acyl, R.sub.9 is hydrogen, lower alkyl, R.sub.10 is hydrogen, lower alkyl or halogen, R.sub.11 is hydrogen, lower alkyl, cycloalkyl or halogen, m is 0 or 1, n is an integer of 2-10, provided, that no more than one of R.sub.1 or R.sub.2 can be hydroxy, alkanoyloxy or ##STR6## and when R is hydrogen, salts thereof with pharmaceutically acceptable bases or when R is --(CH.sub.2).sub.Type: GrantFiled: May 3, 1989Date of Patent: June 18, 1991Assignee: Hoffmann-La Roche Inc.Inventors: Matthew Carson, Ru-Jen L. Han, Ronald A. LeMahieu
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Patent number: 4876343Abstract: An improved process for the preparation of statine, the phenyl analog of statine, the cyclohexyl analog of statine and derivatives thereof is described, as well as other valuable intermediates used in the process.Type: GrantFiled: June 15, 1988Date of Patent: October 24, 1989Assignee: Warner-Lambert CompanyInventors: John C. Hodges, Sylvester Klutchko
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Patent number: 4874886Abstract: This invention relates to novel fluorinated bis(salicylates). The novel fluorinated bis(salicylates) of this invention are useful as monomers in the synthesis of polymers and copolymers themselves useful as gas separation membrane materials.Type: GrantFiled: November 7, 1988Date of Patent: October 17, 1989Assignee: The Dow Chemical CompanyInventor: Charles B. Grant
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Patent number: 4861713Abstract: This invention relates to a method for determination of cholinesterase activity, characterized by using, as a substrate, a choline derivative represented by the general formula (I): ##STR1## wherein X is a halogen atom; Y.sub.1 is a hydroxyl group as a substituent in the 2- or 5-position; and Y.sub.2 is a hydroxyl group as a substituent in the 3-position.The determination method of this invention permits easy and simple determination of cholinesterase activity, and is very useful as a determination method for clinical examinations for the purpose of determining cholinesterase in serum.Type: GrantFiled: April 14, 1987Date of Patent: August 29, 1989Assignee: Nitto Boseki Co., Ltd.Inventors: Katsumasa Kuroiwa, Katsuhiro Katayama, Takeshi Nagasawa
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Patent number: 4853398Abstract: This invention provides benzene derivatives which are leukotriene antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment of conditions characterized by an excessive release of leukotrienes.Type: GrantFiled: April 13, 1987Date of Patent: August 1, 1989Assignee: Eli Lilly and CompanyInventors: F. P. Carr, Robert D. Dillard, Doris E. McCullough
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Patent number: 4751332Abstract: Resorcinol and substituted resorcinols are converted in one single step reaction into 1,2,3- and 1,2,4-trihydroxybenzenes and substituted hydroxy resorcinol compounds with a benzene solution of peroxypropionic acid.Type: GrantFiled: September 14, 1987Date of Patent: June 14, 1988Assignee: Degussa AktiengesellschaftInventors: Guenter Prescher, Gebhard Ritter, Holger Sauerstein
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Patent number: 4683327Abstract: A novel heat-curable acrylic-terminated monomer is provided which exhibits an optically anisotropic melt phase at a temperature which enables it to undergo melt processing in the formation of molded articles, etc. Subsequent to melt processing articles prepared from the monomer are capable of being cured to produce a thermoset self-reinforced composite which is soft and flexible relative to prior art monomers. The monomer may, for example, consist essentially of the reaction product of a methacrylic-substituted phenol and terephthalic acid.Type: GrantFiled: June 24, 1985Date of Patent: July 28, 1987Assignee: Celanese CorporationInventor: Robert W. Stackman
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Patent number: 4670495Abstract: Novel o-bridged polynuclear polyphenols of the formula I ##STR1## which contain at least one organic radical, such as alkyl, cycloalkyl or aryl, per phenyl nucleus and are formed by condensation of the monomeric phenolic components with customary bridging reagents, such as formaldehyde, acetone or sulfur dichloride, or by oxidative coupling of the monomeric phenolic components, and which, depending on the reaction procedure, can contain between 2 and 50 monomer units, are described.The substances according to the invention can be used for stabilizing plastics from oxidative degradation and have a good resistance to extraction.Type: GrantFiled: June 20, 1986Date of Patent: June 2, 1987Assignee: Ciba-Geigy CorporationInventor: Samuel Evans
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Patent number: 4668725Abstract: Organic compounds of phenolic nature for stabilizing organic polymers are described together with the process for preparing said stabilizing compounds. Stabilized polymer compositions incorporating said stabilizing compounds are also described.Type: GrantFiled: October 16, 1985Date of Patent: May 26, 1987Assignees: Enichem Sintesi S.p.A., Bozzetto Industrie Chimiche S.p.A.Inventors: Fabio Broussard, Carlo Busetto
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Patent number: 4661601Abstract: New compounds having the formula 1 ##STR1## wherein W is hydrogen, halogen, n-alkyl, --NHCOR.sup.1, --COR.sup.1, or phenoxyacetylamino optionally substituted by one or two C.sub.1-12 straight- or branched chain alkyl, X is a substituent in the coupling position and is selected from hydrogen, chlorine, bromine, --SR.sup.11 or a nitrogen-containing heterocyclic residue attached at a ring nitrogen atom, and Y is a group having the formula 2 ##STR2## wherein Q is selected from the residues: --COOR.sup.4 or --CONR.sup.4 R.sup.5, --OM, --NR.sup.7 R.sup.8, --PO(OR.sup.9)[O].sub.x R.sup.10 with X=0 or 1, --SO.sub.2 OH, --SO.sub.2 NR.sup.4 R.sup.5 or CN. The groups R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, M, k and n are defined hereinafter.These compounds are used as black color couplers in photographic materials.Type: GrantFiled: April 3, 1985Date of Patent: April 28, 1987Assignee: Ciba-Geigy AGInventor: Frederick H. Howell
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Patent number: 4607120Abstract: A process for the manufacture of esters of formula ##STR1## in which R.sup.1 signifies methyl or ethyl and R.sup.2 and R.sup.3, independently from one another, signify hydrogen or C.sub.1-4 -alkyl,is described. The process comprises treating a diketo ester of the formula ##STR2## in which R.sup.1 to R.sup.3 have the above significances, with the combination ofCuX.sub.2 and MeX.sub.n IIIin which Me signifies an alkali metal or alkaline earth metal ion, X signifies halogen and n corresponds to the valency of the metal ion.Compounds I are known odorants.The reaction involved is thus an aromatization of the starting material.Type: GrantFiled: July 27, 1984Date of Patent: August 19, 1986Assignee: Societe Anonyme Roure Bertrand DupontInventor: Gerard Pelerin
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Patent number: 4551562Abstract: The nuclear hydroxylation of phenol with organic solutions of hydrogen peroxide in the presence of a catalyst is carried out in improved manner by employing both (1) a special, practically water free solution of hydrogen peroxide in an organic solvent which does not form an azeotrope with water or whose highest azeotrope with water, boil near or above the boiling point of hydrogen peroxide, and (2) employing as a catalyst XO.sub.2 where X is sulfur, selenium, or tellurium. Besides increasing the yield and the ability to carry out the reaction in a simpler manner when selenium dioxide is employed as a catalyst, there can also be controlled the ortho-para ratio, respectively, the ortho-ortho ratio of the product.Type: GrantFiled: March 13, 1984Date of Patent: November 5, 1985Assignee: Degussa AktiengesellschaftInventors: Karlheinz Drauz, Axel Kleemann
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Patent number: 4544666Abstract: A chemotherapeutic composition for the control of plant diseases caused by mycoplasma-like organisms, rickettsia-like organisms, or seed-borne legume viruses. The composition is composed essentially of the tannate complex of picro ammonium formate combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate. The preparation and use of the composition are disclosed. Also disclosed is a related chemotherapeutic composition for the control of plant diseases caused by plant pathogenic fungi and bacteria and composed essentially of a tannate complex of picro cupric ammonium formate in aqueous solution combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate, along with its method of preparation and manner of use.Type: GrantFiled: April 22, 1983Date of Patent: October 1, 1985Assignee: Phyton/AG, Inc.Inventors: Mandayam J. Thirumalachar, Mandayam J. Narasimhan, Mandayam J. K. Thirumalachar
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Patent number: 4524216Abstract: Resorcinols of the structure of p-orsellinic acid ester are obtained from pyrones of the formula ##STR1## by the action of no more than catalytic amounts of bases.Type: GrantFiled: September 14, 1983Date of Patent: June 18, 1985Assignee: Dynamit Nobel AGInventor: Hans-Georg Schmidt
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Patent number: 4519936Abstract: The invention relates to nematic liquid crystals in electro-optical components for the modulation of light as well as for the representation of numerals, signs and images and to a method for producing the same.It is the object of the invention to create nematic liquid crystals which are well suited for electro-optical devices, preferably for two-frequency operation.It has been found that pure or mixed 2-n-alkyl-1, 4-bis-[4-acyloxy]-benzenes of the general formula ##STR1## wherein R.sup.3 =n-C.sub.m H.sub.2m+1, with m=3 to 14, are well suited for utilization in electro-optical components.It was found that 2-n-alkyl-1,4-bis-[acyloxy]-benzene which is well suited for electro-optical components, and especially for two-frequency operations, can be produced by the conversion of a correspondingly substituted benzoic acid or cyclohexane carboxylic acid or a reaction-capable derivative thereof with the corresponding 2-n-alkylhydroquinone--also in the form of its phenylate--at a temperature ranging from 0.degree. C.Type: GrantFiled: July 20, 1982Date of Patent: May 28, 1985Assignee: VEB Werk fuer Fernsehelektronik im Kombinat MikroelektronikInventors: Dietrich Demus, Wolfgang Weissflog, Horst Kresse
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Patent number: 4501912Abstract: A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula ##STR1## wherein R may be lower alkyl, lower hydroxyalkyl, lower alkynyl, aralkyl, or an ester-containing group and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.Type: GrantFiled: December 13, 1982Date of Patent: February 26, 1985Assignee: American Hospital Supply CorporationInventors: William L. Matier, Sheung-Tsam Kam
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Patent number: 4448730Abstract: Di, tri and tetrahydroxybenzohydroxamic acids, amides and the corresponding di, tri and tetrahydroxy substituted phenylalkanohydroxamic acids, amides and phenyl esters, ribonucleotide reductase inhibitors.Type: GrantFiled: April 20, 1982Date of Patent: May 15, 1984Inventors: Bartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
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Patent number: 4426332Abstract: A process for the preparation of resorcinol derivatives of the general formula I ##STR1## where R.sup.1 is carbalkoxy, nitrile, alkyl or H and R.sup.2 to R.sup.5 are H or lower alkyl, by reacting the corresponding cyclohexane-1,3-dione (II) with oxygen or an oxygen-containing gas in the presence of a catalytic amount of a copper compound and of from 1 to 10 moles of a hydrogen halide, or from 0.5 to 5 moles of thionyl chloride per mole of II, in an alkanol having from 1 to 6 carbon atoms, tetrahydrofuran or methyl tert.-butyl ether as the solvent, at from 0.degree. to 150 C., without the addition of a significant amount of water to the reaction mixture. Some of the resorcinol derivatives prepared are useful scents with fragrance notes of the character of the odoriferous substance of natural oak moss.Type: GrantFiled: April 21, 1982Date of Patent: January 17, 1984Assignee: BASF AktiengesellschaftInventors: Frank Thoemel, Werner Hoffmann
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Patent number: 4420629Abstract: 3-alkyl-6-methyl-.beta.-resorcylic acid esters of the Formula ##STR1## wherein R.sup.1 and R.sup.2 represent identical or different alkyl groups of 1 to 10 carbon atoms, are prepared by the reaction of .alpha.-pyrones of the formula ##STR2## wherein R.sup.1 and R.sup.2 have the above meaning, with a base.Type: GrantFiled: September 10, 1982Date of Patent: December 13, 1983Assignee: Dynamit Nobel AGInventor: Hans-Georg Schmidt
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Patent number: 4408059Abstract: Milbemycin and avermectin macrolides are synthesized by the cyclized linking of separately synthesized northern and southern hemisphere intermediates. The northern hemisphere intermediate is a spiroketal alkenyl aldehyde, and the southern hemisphere intermediate is an aryl alkenyl phosphine oxide anion.Type: GrantFiled: December 4, 1981Date of Patent: October 4, 1983Assignee: University Patents, Inc.Inventors: Amos B. Smith, III, Steven R. Schow
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Patent number: 4339593Abstract: Dialkyl-substituted .beta.-resorcylic acid esters having the structure: ##STR1## wherein each of R.sub.1, R.sub.2, and R.sub.3 is lower alkyl may be readily prepared by reacting the corresponding dihydroresorcylic acid esters with sulfuryl chloride. These compounds, particularly, methyl 3,6-dimethyl-resorcylate and methyl 3-ethyl-6-methyl-resorcylate, have oakmoss-like odors rendering them valuable as perfume ingredients.Type: GrantFiled: December 16, 1980Date of Patent: July 13, 1982Assignee: Fritzsche Dodge & Olcott Inc.Inventors: Brian J. Willis, David I. Lerner, Derek H. R. Barton
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Patent number: 4324925Abstract: An improved process for the preparation of a polyhydric phenol by hydroxylation of a phenol with a peroxidic hydroxylating agent, is disclosed. The improvement resides in that before the hydroxylation, all or some of the mixture to be hydroxylated is treated with a cation exchanger.Type: GrantFiled: June 30, 1980Date of Patent: April 13, 1982Assignee: Bayer AktiengesellschaftInventors: Christoph Jupe, Helmut Waldmann, Hermann Seifert
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Patent number: 4239903Abstract: Compounds, which have antispasmodic effects, represented by the following formula (I) ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, an alkoxy group or, when taken together, R.sup.1 and R.sup.2 represent an alkylenedioxy group; R.sup.3 represents a hydrogen atom, an alkyl group or a cycloalkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, an alkoxy group, an alkyl group, a halogen atom, a hydroxyl group or, when two of R.sup.4, R.sup.5 and R.sup.6 are taken together, they represent an alkylenedioxy group; and A represents a straight or branched chain alkylene group having 2 to 10 carbon atoms or an alkylene group having 2 to 10 carbon atoms and interrupted with an oxygen atom forming an ether bond therein, and the therapeutically useful acid-addition salts thereof; and a process for producing the same.Type: GrantFiled: May 16, 1978Date of Patent: December 16, 1980Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Sumiro Isoda, Munefumi Kanao, Yoshifumi Ichikawa, Takeshi Hashizume, Kiyoshi Irie, Yoshio Kasai
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Patent number: 4112238Abstract: Crude 2-ethylhexyl gallate is purified by crystallizing it from a system containing an aliphatic hydrocarbon solvent such as hexane and a small proportion of 2-ethylhexanol.Type: GrantFiled: February 17, 1977Date of Patent: September 5, 1978Assignee: Mallinckrodt, Inc.Inventors: Douglas W. Chapman, Hugh C. Bertsch
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Patent number: 4089846Abstract: Novel polymers formed from the reaction of tricarboxylic anhydrides and hydrazines or hydrazides which may be cross-linkable by further reaction with a hydrazine or hydrazide are disclosed.Type: GrantFiled: November 4, 1975Date of Patent: May 16, 1978Assignee: PPG Industries, Inc.Inventors: Karl F. Schimmel, Marco Wismer
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Patent number: T962006Abstract: the invention relates to photopolymerizable polymeric compositions useful as coating and moldable compositions which are hardenable by ultraviolet radiation. These coating and moldable compositions comprise mixtures of photopolymerizable or photocrosslinkable acrylates of bis-(hydroxyalkyl) terephthalates and isophthalates in combination with at least one ethylenically unsaturated monomer component and a photoinitiator.Type: GrantFiled: January 6, 1977Date of Patent: September 6, 1977Inventors: James G. Pacifici, Raymond D. Clark, Gordon C. Newland