Amide Patents (Class 562/450)
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Patent number: 7259276Abstract: The present invention relates to novel compounds, termed serpentemycins, of the formula (I) in which Y, R, R2, R3, R4, X, X2, X3, n, m and o are as defined in the specification, which are formed by the microorganism Actinomycetales sp. DSM 14865 during its fermentation, to chemical derivatives of the serpentemycins, to a process for preparing them, and to their use as pharmaceuticals, in particular for the treatment and prophylaxis of infectious bacterial diseases.Type: GrantFiled: June 27, 2003Date of Patent: August 21, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventors: László Vertesy, Michael Kurz, Joachim Wink
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Patent number: 7250439Abstract: Compounds of formula (I): wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents O, S, NR5 or CR6 R7; Y represents CHOH, CHSH, NOR8, CNR8 or CNOR8; Z represents a bond, CR10R11, O, S, SO, SO2, NR10, OCR10R11, CR10R11 O or Z, R4 and Q together form an optionally substituted fused tricyclic group; R1, R1?, R3 and R3? each independently represents H, C1-6 alkyl or C1-4 alkylaryl; R2 represents CO2R8, CONR5OR9 or NR5COR9; R4 represents optionally substituted 5- or 6-membered aryl or heteroaryl; R5 represents H or C1-3 alkyl; R6 and R7 each independently represents H, C1-3 alkyl or halo; R8 represents H or C1-2 alkyl; R9 represents H or C1-3 alkyl; R10 and R11 each independently represents H, C1-6 alkyl or C1-4 alkylaryl; and physiologically functional derivatives thereof, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described.Type: GrantFiled: June 1, 2004Date of Patent: July 31, 2007Assignee: Glaxo Group LimitedInventors: Simon Gaines, Ian Peter Holmes, Stephen Paul Watson
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Patent number: 7247746Abstract: New crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, also known asnateglinide, may be produced by dissolving nateglinide in any of its forms, including solvates, in an organic solvent to form a solution followed by precipitation of nateglinide from the solution, and isolating and drying the precipitated crystal form of nateglinide. The precipitation of nateglinide may be induced either by cooling the solution, or by addition of another solvent which is miscible with the first solvent but in which nateglinide is only poorly soluble, or by combination of the two. Depending on the solvent a specific crystal form of nateglinide may be obtained, e.g., the R?-type crystal form of nateglinide produced by the described method has a different melting point, infra red spectra and X-ray diffraction patterns from the previously known crystal forms of nateglinide.Type: GrantFiled: April 14, 2003Date of Patent: July 24, 2007Assignee: Novartis, AGInventor: Paul Allen Sutton
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Patent number: 7238834Abstract: The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; R3 is —COOH or —COOR4; R4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.Type: GrantFiled: October 14, 2005Date of Patent: July 3, 2007Assignee: AMR Technology, Inc.Inventor: Thomas E. D'Ambra
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Patent number: 7227033Abstract: The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as insulin, to a target.Type: GrantFiled: January 9, 2003Date of Patent: June 5, 2007Assignee: Emisphere Technologies, Inc.Inventors: Satej Bhandarkar, Shingai Majuru, Halina Levchik
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Patent number: 7214712Abstract: Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1–C6 alkyl, C1–C6 alkoxy, C2–C6 alkenyl, C2–C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; each R4 and R5 independently are H, C1–C6 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring, optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.Type: GrantFiled: September 29, 2005Date of Patent: May 8, 2007Assignee: Warner-Lambert CompanyInventors: Nicole Chantel Barvian, David Thomas Connor, Richard Dennis Dyer, Adam Richard Johnson, William Chester Patt
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Patent number: 7208178Abstract: The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as insulin, to a target.Type: GrantFiled: July 14, 2005Date of Patent: April 24, 2007Assignee: Emisphere Technologies, Inc.Inventors: Satej Bhandarkar, Shingai Majuru, Halina Leuchyk
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Patent number: 7208622Abstract: There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58° C. to 72° C. and the concentration of ketone solvent to more than 8 wt % and less than 22 wt % to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide.Type: GrantFiled: April 18, 2003Date of Patent: April 24, 2007Assignee: Ajinomoto Co., Inc.Inventors: Daisuke Takahashi, Seiichi Nishi, Satoji Takahashi
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Patent number: 7193108Abstract: Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to ? 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning ? 4 integrin, such as inflammatory diseases in which ? 4 integrin-depending adhesion process participates in the pathology, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.Type: GrantFiled: January 26, 2004Date of Patent: March 20, 2007Assignee: Ajinomoto Co., Inc.Inventors: Akira Chiba, Kazuyuki Sagi, Toshihiko Yoshimura, Tatsuya Okuzumi, Hiroyuki Izawa, Masahiro Murata
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Patent number: 7183317Abstract: It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.Type: GrantFiled: July 8, 2004Date of Patent: February 27, 2007Assignee: Atherogenics, Inc.Inventors: James A. Sikorski, Jayraz Luchoomun, Charles Q. Meng, Uday Saxena
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Patent number: 7148376Abstract: Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, ?, ?, ?, ?, ?, ?, ? and ?, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration.Type: GrantFiled: July 18, 2003Date of Patent: December 12, 2006Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan, Boaz Gome
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Patent number: 7084176Abstract: N-Arylphenylacetamide derivatives represented by the following formula [I]: (wherein R1 is C1-6 alkoxy, etc.; R2 is hydrogen, —(CH2)m—N(R6)(R7) (m is an integer of from 1 to 4; R6 is hydrogen, C1-4 alkyl, etc., R7 is hydrogen, etc.), etc.; R3 is hydrogen, halogen, etc.; R4 is C6-10 alkyl, —Y—R8 (Y is a single bond, C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, etc., R8 is aryl, C3-8 cycloalkyl, C6-15 polycycloalkyl, etc.), etc.; R5 is hydrogen, etc.; and X1 is hydrogen), or pharmaceutically acceptable salts thereof or hydrates or solvates of the same, and a pharmaceutical composition containing the same. These compounds are useful as preventives and/or remedies giving no pain at the early stage of administration, which are efficacious in oral administration and have potent analgesic and antiinflammatory effects.Type: GrantFiled: June 6, 2002Date of Patent: August 1, 2006Assignee: Dainippon Pharmaceutical Co., Ltd.Inventors: Toshiya Morie, Keiji Adachi, Kazumi Niidome, Katsuyoshi Kawashima, Isao Shimizu, Daisuke Ishii
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Patent number: 7064229Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseasesType: GrantFiled: June 24, 2002Date of Patent: June 20, 2006Assignee: Bayer Healthcare AGInventors: Thomas Rolle, Thomas Lehmann, Markus Albers, Gerhard Muller, Gerhard Hessler, Rudiger Fischer, Masaomi Tajimi, Karl Ziegelbauer, Kevin Bacon, Haruki Hasegawa, Hiromi Okigami
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Patent number: 7056707Abstract: The present invention relates to a novel compound having a molecular formula C13H15NO5 having molecular structure of Formula I and a process for the isolation of said compound. The present invention also relates to a method of inhibiting 13-lipoxygenase and having free radical scavenging activity.Type: GrantFiled: December 2, 2003Date of Patent: June 6, 2006Assignee: Council of Scientific and Industrial ResearchInventors: Avinash Prahlad Sattur, Chandrasekhar Rao Kadiyala, Divakar Soundar, Karanth Naikanakatte Ganesh, Tumkur Ramachandraiah Shamala, Appu Rao Appu Rao Gopal Rao
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Patent number: 7049342Abstract: The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor ? (PPAR?) to activate and exhibit potent lipid-decreasing action, and processes for preparing them.Type: GrantFiled: May 25, 2001Date of Patent: May 23, 2006Assignee: Kyorin Pharmaceutical Co., Ltd.Inventors: Hiroyuki Miyachi, Masahiro Nomura, Yukie Takahashi, Takahiro Tanase, Kouji Murakami, Masahiro Suzuki
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Patent number: 7045653Abstract: The invention relates to NEP inhibitors for treating cardiovascular disorders. Preferred NEP inhibitors are compounds of formula (I) wherein R1 is C1–C6alkyl, C1–C6alkoxyC1–C3alkyl or C1–C6alkoxyC1–C6alkoxyC1–C3alkyl; R2 is hydrogen or C1–C6alkyl; L is a three atom linkage selected from —CH2—X—CH2— and —CH2—CH2—X— where the right hand side of the linkage is attached to R3 and where X is oxygen, sulfur or methylene; R3 is phenyl or aromatic heterocyclyl, either of which may be independently substituted by one or more groups selected from: C1–C6alkyl, halo, haloC1–C6alkyl, C1–C6alkoxy, haloC1–C6alkoxy, C1–C6alkylthio, haloC1–C6alkylthio and nitrile; and R4 and R5 are either both hydrogen, or one of R4 and R5 is hydrogen and the other is a biolabile ester-forming group that in the body of a patient is replaced by hydrogen.Type: GrantFiled: December 18, 2003Date of Patent: May 16, 2006Assignee: Pfizer, Inc.Inventors: Kevin Neil Dack, Robert John Maguire
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Patent number: 7030268Abstract: There is provided a method for producing easily highly-purified acylphenylalanine that is useful as a raw material of pharmaceutical products and the like, which comprises the step of reacting an acid chloride with phenylalanine in a mixed solvent of an organic solvent and water, while keeping the solvent under the alkali condition by using potassium hydroxide.Type: GrantFiled: April 18, 2003Date of Patent: April 18, 2006Assignee: Ajinomoto Co., Inc.Inventors: Michito Sumikawa, Takao Ohgane
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Patent number: 7026501Abstract: The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: August 27, 2001Date of Patent: April 11, 2006Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Takayuki Kawaguchi, Sumihiro Nomura, Mikiko Tsukimoto, Toshiyuki Kume
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Patent number: 6992207Abstract: The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of carcinogenic diseases. Further, the invention refers to a pharmaceutical composition comprising the alkylating peptides of the invention.Type: GrantFiled: June 11, 2001Date of Patent: January 31, 2006Assignee: Oncopeptides ABInventors: Rolf Lewensohn, Joakim Gullbo, Rolf Larsson, Hans Ehrsson, Kristina Luthman
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Patent number: 6962899Abstract: Pharmaceutically acceptable compounds for administering to a subject, comprising the general structure II: wherein R1 is an L-amino acid or salt or ester thereof, or an L-amino acid containing peptide or salt or ester thereof; and wherein the stereochemistry about the carbon-carbon double bond is trans. The invention further relates to pharmaceutical compositions comprising the aforementioned compounds.Type: GrantFiled: December 4, 2002Date of Patent: November 8, 2005Assignees: Georgia Tech Research Corporation, Mercer UniversityInventors: Sheldon W. May, Stanley H. Pollock
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Patent number: 6939889Abstract: Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.Type: GrantFiled: December 23, 2003Date of Patent: September 6, 2005Assignee: UCB Farchim SAInventors: Gregory N. Beatch, Lewis S. L. Choi, Clive P. Page, Bertrand M. C. Plouvier, Yuzhong Liu
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Patent number: 6936597Abstract: Polymeric prodrugs of the formula: wherein B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing moieties; Y1 is selected from the group consisting of O, S, and NR5; M is NR3, O or S; Ar is a moiety which when included in Formula I forms a multi-substituted aromatic or heteroaromatic hydrocarbon or a multi-substituted heterocyclic group; (m) is zero or a positive integer; R1-3 and R5 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy and C1-6 heteroalkoxy; and R4 is a polymeric residue; as well as methods of making and using the same are disclosed.Type: GrantFiled: March 21, 2002Date of Patent: August 30, 2005Assignee: Enzon, Inc.Inventors: Richard B. Greenwald, Yun H. Choe
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Patent number: 6930106Abstract: The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.Type: GrantFiled: June 30, 2003Date of Patent: August 16, 2005Assignee: Pharmacia & UpJohn CompanyInventors: Barry Craig Finzel, Lee A. Funk, Robert Charles Kelly, Matthew T. Reding, Nancy Anne Wicnienski
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Patent number: 6903232Abstract: This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula II is decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic.Type: GrantFiled: July 2, 2003Date of Patent: June 7, 2005Assignee: Aurobindo Pharma Ltd.Inventors: Ramesh Dandala, Umashankar Das, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran
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Patent number: 6900344Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.Type: GrantFiled: March 21, 2001Date of Patent: May 31, 2005Assignee: Emisphere Technologies, Inc.Inventors: Joseph N. Bernadino, Doris C. O'Toole, William E. Bay
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Patent number: 6887877Abstract: The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating Flaviviridae viral infection.Type: GrantFiled: June 11, 2002Date of Patent: May 3, 2005Assignee: ViroChem Pharma Inc.Inventors: Laval Chan Chun Kong, Jean Bedard, Sanjoy Kumar Das, Nghe Nguyen Ba, Oswy Z. Pereira, Stephen Joseph Shuttleworth, Mohammad Arshad Siddiqui, Wuyi Wang
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Patent number: 6861553Abstract: Provided is a process for preparation of an intermediate in the synthesis of nateglinide. Trans-4-isopropylcyclohexane acid chloride is formed by reacting 4-isopropylcyclohexanecarboxyl acid with thionyl chloride in the presence of an effective amount of an organic amide. Also provided are processes for preparation of nateglinide by acylation of a suitable salt of D-phenylalanine with trans-4-isopropylcyclohexane acid chloride in both a single and a two phase system, and in water free of a co-solvent.Type: GrantFiled: July 3, 2003Date of Patent: March 1, 2005Assignee: Teva Pharmaceuticals Industries Ltd.Inventors: Ronit Yahalomi, Evgeny Shapiro, Ben-Zion Dolitzky, Yigael Gozlan
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Patent number: 6849649Abstract: The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, —NR2R3 or —NR4SO2R5; X is the linkage —(CH2)n— or —(CH2)q—O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.Type: GrantFiled: October 28, 2003Date of Patent: February 1, 2005Assignee: Pfizer Inc.Inventors: Stephen Challenger, Andrew Simon Cook, Adam Thomas Gillmore, Donald Stuart Middleton, David Cameron Pryde, Alan Stobie
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Patent number: 6849648Abstract: A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful for treating diseases mediated by MMP-13, including cancer and arthritis.Type: GrantFiled: October 4, 2002Date of Patent: February 1, 2005Assignee: Warner-Lambert CompanyInventors: Amy Mae Bunker, William Glen Harter, James Lester Hicks, Patrick Michael O'Brien, Ly Pham, Joseph Armand Picard, William Howard Roark
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Publication number: 20040266789Abstract: Disclosed are compounds and pharmaceutically acceptable salts of formula (I): 1Type: ApplicationFiled: April 30, 2004Publication date: December 30, 2004Inventors: Darren Whitehouse, Shaojing Hu, Michael C. Van Zandt, Garrett Parker, Thomas G. Meskill
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Publication number: 20040265248Abstract: These are described biphenylene compounds of formula (I) wherein R1 is a C1-C18alkyl, C2-C18alkenyl, C6-C10aryl or C6-C10aryl or C6-C10heteroaryl radical each unsubstituted or mono- or poly-substituted by hydroxy, halogen, C1-C18alkyl, C1-C18alkoxy, amino, C1-C5monoalkyamino or by di-C1-C5alkylamino; C5-C7cycloalkyl or C5-C7cycloalkenyl each unsubstituted or substituted by C1-C5alkyl; —OR′; or NR′R″; R2 is a C1-C18alkyl, C2-C18alkenyl, C6-C10aryl or C6-C10heteroaryl radical each unsubstituted or mono- poly-substituted by hydroxy, hadroxy, C1-C18alkoxy, amino, C1-C5monoalkylamino or by di-C1-C5alkylamino; —OR′; —NR′R″; or R1 and R2 together form a 5- to 7- membered monocyclic carbocyclic or heterocyclic ring; R3 is hydrogen; C1-C6alkyl or C1-C6alkoxy; R′ and R″ are each independently of the other hydrogen; unsubstituted or mono- or poly-hydroxy-, halo-, C1-C18alkyl-, C1-C18alkoxy-, amino- or quaternary ammonium groupsubstituted C1-C18alkyl, C5-CType: ApplicationFiled: March 3, 2004Publication date: December 30, 2004Inventors: Barbara Wagner, Dietmar Huglin
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Publication number: 20040267012Abstract: Compounds of formula (I): wherein when m is 0 to 4 R1 is selected from C1-6alkyl, C3-7cycloalkyl, C2-6alkenyl, —SO2NR4R5, —CONR4R5 and —COOR4; and when m is 2 to 4 R1 is additionally selected from C1-6alkoxy, hydroxy, NR4R5, —NR4SO2R5, —NR4SOR5, —NR4COR5, and —NR4CONR4R5; R2 is selected from hydrogen, C1-6alkyl and —(CH2)n-C3-7cycloalkyl; R3 is the group —CO—NH—(CH2)p-R6; U is selected from methyl and halogen; W is selected from methyl and chlorine; V and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4 wherein each carbon atom of the resulting carbon chain may be optionally substituted with one or two groups selected independently from C1-6alkyl; n is selected from 0, 1, 2 and 3; p and r are independently selected from 0, 1 and 2; s is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitorsType: ApplicationFiled: April 15, 2004Publication date: December 30, 2004Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, George Stuart Cockerill, Suzanne Joy Merrick, Kathryn Jane Smith, Ann Louise Walker
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Publication number: 20040266870Abstract: (R)-Enantiomers of quaternary ammonium salts of general formula (I) are described: 1Type: ApplicationFiled: April 8, 2004Publication date: December 30, 2004Inventors: Marcello Allegretti, Riccardo Bertini, Cinzia Bizzarri, Maria Candida Cesta
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Publication number: 20040266788Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): 1Type: ApplicationFiled: April 14, 2004Publication date: December 30, 2004Applicant: The Institute for Pharmaceutical Discovery LLCInventors: Michael C. Van Zandt, Darren Whitehouse, Kerry Combs, Shaojing Hu
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Publication number: 20040259950Abstract: A novel class of dicarboxylic acid derivatives, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR).Type: ApplicationFiled: December 12, 2003Publication date: December 23, 2004Inventors: Per Sauerberg, Lone Jeppesen, Zdenek Polivka, Karel Sindelar
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Publication number: 20040260108Abstract: This invention provides metabolites of a class of androgen receptor targeting agents (ARTA).Type: ApplicationFiled: May 20, 2004Publication date: December 23, 2004Inventors: James T. Dalton, Duane D. Miller, Donghua Yin, Yali He
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Publication number: 20040248937Abstract: The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): 1Type: ApplicationFiled: April 14, 2004Publication date: December 9, 2004Applicant: The Institute for Pharmaceutical Discovery LLCInventors: Michael C. Van Zandt, Haiguan Fang, Shaojing Hu, Darren Whitehouse
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Publication number: 20040248983Abstract: N-Arylphenylacetamide derivatives represented by the following formula [I]: 1Type: ApplicationFiled: December 11, 2003Publication date: December 9, 2004Inventors: Toshiya Morie, Keiji Adachi, Kazumi Niidome, Katsuyoshi Kawashima, Isao Shimizu, Daisuke Ishii
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Publication number: 20040248811Abstract: The present invention relates to a compound represented as formula (I): 1Type: ApplicationFiled: December 31, 2003Publication date: December 9, 2004Applicant: Industrial Technology Research InstituteInventors: Jenn-Tsang Hwang, Yu-Long Chang, Chung-Niang Yao, Chrong-Shiong Hwang
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Publication number: 20040248887Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.Type: ApplicationFiled: March 23, 2004Publication date: December 9, 2004Applicant: IRM LLCInventors: Hong Liu, Phil Alper, Arnab Chatterjee, David Tully, Badry Bursulaya, David Woodmansee, Robert Epple, Jennifer Leslie Harris, Jun Li
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Publication number: 20040242652Abstract: L-threo-&bgr;-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): 1Type: ApplicationFiled: July 19, 2004Publication date: December 2, 2004Inventor: Keiko Shimamoto
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Publication number: 20040236147Abstract: Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to &agr; 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning &agr; 4 integrin, such as inflammatory diseases in which &agr; 4 integrin-depending adhesion process participates in the pathology, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.Type: ApplicationFiled: January 26, 2004Publication date: November 25, 2004Applicant: AJINOMOTO CO. INCInventors: Akira Chiba, Kazuyuki Sagi, Toshihiko Yoshimura, Tatsuya Okuzumi, Hiroyuki Izawa, Masahiro Murata
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Publication number: 20040235825Abstract: A carboxylic acid derivative of formula (I) 1Type: ApplicationFiled: June 10, 2004Publication date: November 25, 2004Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Kousuke Tani, Masaki Osada, Kaoru Kobayashi, Masami Narita, Mikio Ogawa
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Publication number: 20040231556Abstract: The present invention provides an anti-curl agent containing an amide compound of specific structure and molecular weight, an ink jet ink containing the amide compound, a method for ink jet recording to form images by ejecting the ink, and a method for reducing curl of recording media using the ink. The anti-curl agent of the present invention can reduce shape changes of a printed paper with a lapse of time, i.e., the curl phenomenon, tending to occur in particular with a plain paper printed over the entire surface, without deteriorating image quality.Type: ApplicationFiled: June 24, 2004Publication date: November 25, 2004Applicant: Canon Kabushiki KaishaInventors: Masako Shimomura, Hiromichi Noguchi, Kenji Shinjo, Yutaka Kurabayashi, Hirofumi Ichinose, Minako Kawabe
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Publication number: 20040229910Abstract: The present invention relates to certain novel benzylamine derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly in the treatment of depression.Type: ApplicationFiled: November 19, 2003Publication date: November 18, 2004Inventors: Fredericus Antonius Dijcks, Dirk Leysen, Joannes Theodorus Maria Linders, Gerardus Stephanus Franciscus Ruigt, Ian Craig Carlyle, Simon James Anthony Grove, Duncan Robertson Rae, Simon N. Thorn
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Publication number: 20040229904Abstract: The invention relates to compounds of formula (1) 1Type: ApplicationFiled: May 6, 2004Publication date: November 18, 2004Applicant: Pfizer IncInventors: Mark Edward Bunnage, Paul Alan Glossop, Charlotte Alice Louise Lane, Russell Andrew Lewthwaite
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Publication number: 20040229848Abstract: The present invention relates dipeptidyl peptidase IV inhibition and, more particularly, relates to glutaminyl derivatives, wherein the glutamin residue is bound in a peptide manner to a moiety which imitates the amino acid residue prolin, especially to a nitrogen containing moiety, pharmaceutical compositions containing said compounds, and the use of said compounds in inhibiting dipeptidyl peptidase IV and dipeptidyl peptidase IV-like enzyme activity.Type: ApplicationFiled: May 5, 2004Publication date: November 18, 2004Inventors: Hans-Ulrich Demuth, Matthias Hoffmann, Torsten Hoffmann, Andre J. Niestroj, Stephan Schilling, Ulrich Heiser
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Publication number: 20040224077Abstract: The present invention pertains to specific peptides obtainable from cocoa beans and giving rise to a particular and distinct savor when subjected to a Maillard reaction with reducing sugars. In particular, the present invention pertains to the use of one or more of these specific peptides for the preparation of a chocolate flavor, specifically a cocoa and a caramel flavor, a floral or specifically, a bonbon flavor, a bready flavor, a roasted flavor or a meat flavor.Type: ApplicationFiled: March 30, 2004Publication date: November 11, 2004Inventors: Sunil Kochhar, Carl Erik Hansen, Marcel Alexandre Juillerat
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Publication number: 20040225012Abstract: The present invention relates to a novel compound having a molecular formula C13H15NO5 having molecular structure of Formula I and a process for the isolation of said compound. The present invention also relates to a method of inhibiting 13-lipoxygenase and having free radical scavenging activity.Type: ApplicationFiled: December 2, 2003Publication date: November 11, 2004Inventors: Avinash Prahalad Sattur, Chandrasekar Rao Kadiyala, Divakar Soundar, Karanth Naikanakatte Ganesh, Tumkur Ramachandraiah Shamala, Appu Rao Appu Rao Gopal Rao
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Publication number: 20040220411Abstract: Novel compounds of the formula (I) in which R1, R2, R3, R4, X and Z are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders and for the treatment of tumours.Type: ApplicationFiled: October 16, 2003Publication date: November 4, 2004Inventors: Werner Mederski, Bertram Cezanne, Dieter Dorsch, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes