Acyclic Carbon Bonded Directly To The -c(=x)- Group Patents (Class 562/55)
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Publication number: 20150086911Abstract: An actinic ray-sensitive or radiation-sensitive resin composition includes; a compound (A) which generates an acid by irradiation with actinic rays or radiation, wherein the acid is linked with a group represented by the following general formula (M) through covalent bonding. In the formula, Y1 and Y2 each independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aryl group, or an acyl group. Z represents a hydrogen atom or a substituent.Type: ApplicationFiled: December 4, 2014Publication date: March 26, 2015Applicant: FUJIFILM CorporationInventors: Takuya TSURUTA, Tomotaka TSUCHIMURA, Tadeteru YATSUO
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Publication number: 20140026333Abstract: Reactive dyes of formula (1), wherein R1 and R2 are each independently of the other hydrogen or unsubstituted or substituted C1-C4alkyl, one of the radicals D1 and D2 is a radical of the formula (2), the other one of the radicals D1 and D2 is a radical of the formula (3a), or (3b), wherein (R3)n denotes n identical or different substituents selected from the group C1-C4alkyl, C1-C4alkoxy and sulfo, Z1 is a radical of the formula —SO2—Y (4a), —CONH—(CH2)p—SO2—Y (4b), —NH—CO—CH(Hal)-CH2-Hal (4c), —NH—CO—C(Hal)?CH2 (4d), or (4e), wherein X1 is halogen, T1 independently has the definition of X1, is a non-fibre-reactive substituent or is a fibre-reactive radical of the formula (5a), —NH—(CH2)2-3—SO2—Y (5b), or —NH—(CH2)2-3—O—(CH2)2-3—SO2—Y (5c), R4 is hydrogen or unsubstituted or substituted C1-C4alkyl, (R5)0-2 denotes from 0 to 2 identical or different substituents from the group C1-C4alkyl, C1-C4alkoxy and sulfo, Hal is halogen, Y is vinyl or a —CH2—CH2—U radical and U is a group that is removable under alkalineType: ApplicationFiled: March 5, 2012Publication date: January 30, 2014Inventors: Georg Roentgen, Laszlo Fekete, Michael Nicollet
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Publication number: 20130237702Abstract: A composition containing a compound represented by General Formula (I) below (see the definition in the specification for the symbols in the formula) or a salt thereof has an excellent CaSR agonistic effect and provides a pharmaceutical agent, a CaSR agonistic agent, a prophylactic or therapeutic agent for a disease that can be ameliorated through CaSR activation as well as seasonings and an agent for imparting kokumi.Type: ApplicationFiled: August 31, 2012Publication date: September 12, 2013Applicant: AJINOMOTO CO., INC.Inventors: Masayuki SUGIKI, Toru OKAMATSU, Tetsuo YANO, Shinya TANIGUCHI
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Publication number: 20120322717Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.Type: ApplicationFiled: May 22, 2009Publication date: December 20, 2012Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
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Publication number: 20120277264Abstract: An object of the present invention is to provide an antithrombotic agent that has fewer side effects and that is highly effective. The present invention provides an antithrombotic agent comprising (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium p-toluenesulfonate represented by Formula (1) as an active ingredient.Type: ApplicationFiled: November 25, 2010Publication date: November 1, 2012Applicants: Taiho Pharmaceutical Co., Ltd., Tokai University Educational SystemInventors: Hideyuki Ishida, Mamoru Kiniwa
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Patent number: 8207373Abstract: HPV inhibitors with formula (I) where G1 represents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, G2 represents a group (see formula Ia+Ib) or R represents a hydrogen, an alkyl, halogenoalkyl, or a prodrug radical such as carbamate, acetyl or dialkylaminomethyl, G represents a bond or a hydrocarbonated chain possibly substituted by one or two alkyls, W represents an oxygen or sulphur, R1 and R2 each represent a group chosen from among hydrogen, halogen, hydroxyl, thio, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or halogenoalkyl, R3 represents an acid or a prodrug radical of the acid function or a bioisostere of the acid function, A represents an aryl, cycloalkyl, cycloalkenyl or a heterocycle, each possibly substituted, and B represents an aryl or a heterocycle with 6 chains, each possibly substituted, and pharmaceutically acceptable salts.Type: GrantFiled: May 18, 2007Date of Patent: June 26, 2012Assignee: Anaconda PharmaInventors: Marta Blumenfeld, Delphine Compere, Jean-Michel Gauthier
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Publication number: 20120108551Abstract: The present invention relates to compositions that may alleviate symptoms of ocular stress, as well as methods of their production, use, and storage compositions. The compositions comprise at least one ocular epithelial cell associating group and at least one hydrophilic group. In one embodiment the at least one ocular epithelial cell associating group and at least one hydrophilic group are substituents on a conjugated polyaromatic core. The compositions may be used in ophthalmic compositions and ophthalmic devices.Type: ApplicationFiled: October 29, 2010Publication date: May 3, 2012Inventors: Frank F. Molock, JR., John C. Heaton
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Publication number: 20110034528Abstract: The present invention describes Elansolids, a new class of novel anti-bacterial compounds of formula (I).Type: ApplicationFiled: February 19, 2009Publication date: February 10, 2011Inventors: Klaus Gerth, Heinrich Steinmetz, Gerhard Höfle
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Publication number: 20100298200Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.Type: ApplicationFiled: May 22, 2009Publication date: November 25, 2010Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
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Patent number: 7667048Abstract: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.Type: GrantFiled: December 29, 2007Date of Patent: February 23, 2010Assignee: Aries Associates, Inc.Inventors: Ram Bhatt, Michael J. Conrad, Azzouz Bencheikh, Yifeng Xiong
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Patent number: 7317111Abstract: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.Type: GrantFiled: September 23, 2003Date of Patent: January 8, 2008Assignee: Aries Associates, Inc.Inventors: Ram Bhatt, Michael J. Conrad, Azzouz Bencheikh, Yifeng Xiong
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Patent number: 7008935Abstract: Stable, topically applicable cosmetic/dermatological sunscreen compositions, well suited for the UV-photoprotection of human skin/keratinous materials, contain a thus effective amount of at least one novel amine, amide, sulphonamide or carbamate substituted benzalmalonic salt compound.Type: GrantFiled: February 27, 2004Date of Patent: March 7, 2006Assignee: L'orealInventors: Hervé Richard, Bernadette Luppi
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Patent number: 6222067Abstract: A compound of the following formula (I): wherein R1 is hydrogen or C1-7 acyl, R2 is C1-3 alkylene, n is 0 or 1. Novel dyestuff intermediates of formula (I) compound of the present invention can be used to synthesis many kinds of dyestuffs. Also disclosed is a process for the preparation of compound of formula (I).Type: GrantFiled: February 8, 2000Date of Patent: April 24, 2001Assignee: Everlight USA, Inc.Inventors: Keh-Loong Chen, Ta-Chung Yin
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Patent number: 5968916Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds are particularly useful for systemic control of pests.Type: GrantFiled: January 12, 1998Date of Patent: October 19, 1999Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Peter Gerrard Ruminski, Gopichand Yalamanchili
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Patent number: 5906985Abstract: Pharmaceutical compounds of the formula ##STR1## in which n is 0, 1 or 2 and m is 1 or 2, R.sup.1 is hydrogen, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, phenyl, naphthyl, C.sub.1-10 alkyl-phenyl, C.sub.2-10 alkenyl-phenyl or C.sub.2-10 alkynyl-phenyl, said phenyl and naphthyl groups being optionally substituted, R.sup.2 is hydrogen or a protecting group, and Q is an acidic group; or a salt or ester thereof.Type: GrantFiled: August 21, 1997Date of Patent: May 25, 1999Assignees: Eli Lilly and Company Limited, Lilly, S.A.Inventors: Stephen Richard Baker, Almudena Rubio Esteban, John Goldsworthy, Concepcion Pedregal Tercero
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Patent number: 5789557Abstract: Reactive dyes of the formula ##STR1## where n is 1 or 2,R.sup.1 is hydrogen or hydroxysulfonyl,R.sup.2 is hydrogen or hydroxyl,R.sup.3 is substituted C.sub.1 -C.sub.4 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl or substituted phenyl,R.sup.4 is hydrogen or R.sup.3 and R.sup.4, together with the nitrogen atom linking them, form a heterocyclic radical andD is a radical of a diazo or tetrazo component, each having at least one mechanism,their use for dyeing or printing hydroxyl-containing or nitrogen-containing organic substrates, and novel aminonaphthalenes.Type: GrantFiled: March 27, 1997Date of Patent: August 4, 1998Assignee: Basf AktiengesellschaftInventors: Jurgen Dornhagen, Heike Kilburg, Manfred Patsch, Hermann Loffler, Ortwin Schaffer
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Patent number: 5663442Abstract: The invention relates to a process for the preparation of compounds of the formula ##STR1## characterized in that the radical X in sulphones of the formulaX--(CH.sub.2 --CH.sub.2 --O).sub.m --(CH.sub.2).sub.n --SO.sub.2 --CH.sub.2 --CH.sub.2 OH (2)is replaced by ##STR2## or a compound of the formula ##STR3## is added to the sulphone of the formulaCH.sub.2 =CH--SO.sub.2 --CH.sub.2 --CH.sub.2 --OH (3),the substituents having the meanings given in the description.Type: GrantFiled: May 31, 1995Date of Patent: September 2, 1997Assignee: Bayer AktiengesellschaftInventors: Wolfgang Harms, Udo-Winfried Hendricks, Karl-Josef Herd, Klaus Kunde
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Patent number: 5463112Abstract: This invention concerns novel sulphoperoxyacids having the following generic formula ##STR1## wherein the R', R", and M are as defined in the specification. Bleach compositions and methods of bleaching using such novel sulphoperoxyacids are also taught.Type: GrantFiled: February 2, 1993Date of Patent: October 31, 1995Assignee: Solvay Interox LimitedInventors: John P. Sankey, William Sanderson, Graham R. Horne
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Patent number: 5359131Abstract: Sulfonic acid stilbenes are disclosed which block the infection of cells by HSV, HIV and CMV.Type: GrantFiled: August 13, 1993Date of Patent: October 25, 1994Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Alan D. Cardin, Norton P. Peet, Nelsen L. Lentz
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Patent number: 5210287Abstract: The present invention is directed to novel 2,5-dichlorophenylthioglycolic acid derivative, a process for their production and a process for producing the desired product 2,5-dichlorophenylthioglycolic acid derived from said novel compounds. 2,5-dichlorophenylthioglycolic acid derivative of the present invention can be obtained by reacting 2,4,5-trichlorobenzensulfonates and thioglycolic acid in the presence of base, and said desired product can be obtained by desulfonating said compound in an aqueous solution of mineral acid. Novel 4-carboxymethylthio-2,5-dichlorobenzenesulfonates of the present invention can be used advantageously as an intermediate for the production of 2,5-dichlorophenylthioglycolic acid. The use of said intermediate makes it possible to obtain the desired product in a decreased process steps with high yield. In addition, it poses no problem of environmental pollution as pointed out with conventional methods because it uses no heavy metals.Type: GrantFiled: January 23, 1992Date of Patent: May 11, 1993Assignee: Sumitomo Seika Chemicals Co., Ltd.Inventors: Hiroshi Goda, Nario Kimura, Naohiro Yoshikawa, Katsuhiko Yoshida
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Patent number: 5206426Abstract: Phenylene diamines of the formula ##STR1## in which R.sup.1 denotes hydrogen, formyl or oxalyl,R.sup.2 denotes hydrogen or C.sub.1 -C.sub.4 -alkyl andR.sup.3 denotes hydrogen or C.sub.2 -C.sub.8 -alkanoyl,provided that R.sup.1 and R.sup.2 are not both hydrogen and that when R.sup.2 is methyl or ethyl, R.sup.1 and R.sup.3 are not both hydrogen, and a process for the preparation of phenylene diamines.Type: GrantFiled: December 31, 1991Date of Patent: April 27, 1993Assignee: BASF AktiengesellschaftInventors: Klaus Pandl, Manfred Patsch
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Patent number: 5132432Abstract: The invention relates to novel fluorescent dyes based on the following pyrenyloxy sulfonic acid structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is --OCH.sub.2 C(O)OCH.sub.3, --OCH.sub.2 CON(O)H, --OCH.sub.2 CON.sub.3, --OCH.sub.2 CONHNH.sub.2, ##STR2## or --CH.sub.2 CONH(CH.sub.2).sub.n NH.sub.2 where n is an integer from 1 to 10; at least one of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is sulfonic acid or alkali salts of sulfonic acid; and all other of R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are hydrogen or a hydroxyl group. The new reagents contain functional groups typically found in biomolecules or polymers. The spectral properties of the fluorescent dyes are sufficiently different in wavelengths and intensity from fluorescein as to permit simultaneous use of both dyes with minimum interference.Type: GrantFiled: September 22, 1989Date of Patent: July 21, 1992Assignee: Molecular Probes, Inc.Inventors: Richard P. Haugland, James E. Whitaker
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Patent number: 5013854Abstract: An improved process for preparing trialkylsilyl ester and acid halide derivatives of carboxylic acids is provided along with novel trialkylsilyl ester intermediates of 2-(2-furyl)-2-methoximinoacetic acid.Type: GrantFiled: February 2, 1989Date of Patent: May 7, 1991Assignee: Eli Lilly and CompanyInventor: Charles A. Bunnell
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Patent number: 4908478Abstract: A single-vessel process for preparing 2-acetaminonaphthalene-6-sulfonic acid of high purity by sulfonating 2-hydroxynaphthalene with concentrated sulfuric acid, converting the 2-hydroxynaphthalenesulfonic acid formed with ammonia in the presence of ammonium hydrogensulfite into 2-amino-naphthalene-6-sulfonic acid (Bucherer reaction) and N-acetylating the latter to give 2-acetaminonaphthalene-6-sulfonic acid, which comprises, after diluting the sulfonating melt with water, substantially removing any impurities still present in the resulting aqueous solution of 2-hydroxynaphthalene-6-sulfonic acid, in particular 2-hydroxynaphthalene, by extraction with toluene or xylene and/or clarification using active carbon.Type: GrantFiled: November 10, 1988Date of Patent: March 13, 1990Assignee: Hoechst AktiengesellschaftInventors: Otto Arndt, Theodor Papenfuhs
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Patent number: 4844841Abstract: Compounds of formula ##STR1## wherein X is long-chain alkyloxy, long-chain alkylamino or long-chain dialkylamino,M is alkali metal, pyridinium or ammonium,Y is hydroxy or long-chain alkyloxy,which are especially useful in photometric and fluorimetric investigations of lipids and lipid-water interactions and of cationic biomolecules such as nicotine adenine dinucleotide.Type: GrantFiled: September 11, 1987Date of Patent: July 4, 1989Inventors: Ernst Koller, Otto S. Wolfbeis