Abstract: An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.

Abstract: The present invention addresses the problem of providing a method for producing purified methionine, the method being capable of preventing the caking of methionine. The present invention pertains to a method for producing purified methionine from crude methionine, the method comprising (1) a step for obtaining a wet cake of washed crude methionine, (2) a step for adjusting the pH of the wet cake, and (3) a step for drying the wet cake after the pH adjustment, wherein the pH of the wet cake after the pH adjustment is 5.2-6.1.

Abstract: The present invention addresses the problem of providing a method for producing purified methionine, the method being capable of preventing the caking of methionine. The present invention pertains to a method for producing purified methionine from crude methionine, the method comprising (1) a step for obtaining a wet cake of washed crude methionine, (2) a step for adjusting the pH of the wet cake, and (3) a step for drying the wet cake after the pH adjustment, wherein the pH of the wet cake after the pH adjustment is 5.2-6.1.

Abstract: The present invention relates to a green process for purification of free bio amino acids from plant parts, particularly tea leaves and shoots. The invention more particularly relates to an organic solvent free, fast and economical process for purification of natural amino acids on large scale without using any chemical, acid or alkali substance. The invention also relates to a process for purification of bio amino acids from plant and plant parts (renewable bioresources) which are rich in free amino acids.

Abstract: The invention relates to a method for producing a purified solution containing L-cysteine from a fermentation broth containing L-cysteine. In said method, the fermentation broth containing L-cysteine, at a pH value from pH 6 to 9, is brought in contact with a basic anion exchanger, wherein the L-cysteine bonds to the anion exchanger. The anion exchanger is then rinsed with a first washing solution, and the bonded L-cysteine is removed from the anion exchanger by means of an acid and transferred into an eluate. Said eluate, having a pH?4, is brought in contact with an acidic cation exchanger, wherein the L-cysteine bonds to the cation exchanger. The cation exchanger is rinsed with a second washing solution, and the bonded L-cysteine is removed from the cation exchanger by means of a strong acid.

Abstract: Methods for producing nanoparticle thin films are disclosed. According to one of the methods, a nanoparticle thin film is produced by modifying the surface of nanoparticles to allow the nanoparticles to be charged, controlling an electrostatic attractive force between the charged nanoparticles and a substrate and a repulsive force between the individual nanoparticles by a variation in pH to control the number density of the nanoparticles arranged on the substrate.

Abstract: Provided is a method for preparing stable free flowing solid aminocarboxylate chelants by adding to a chelant that contains residual alkaline metal hydroxide a free or partially neutralized carboxylic acid such that the free or partially neutralized acid neutralizes at least a portion of the alkaline metal hydroxide; and isolating therefrom the free-flowing solid chelant.

Abstract: Method for enantioseparation of a chiral system with compound formation comprising a pair of enantiomers. The method comprises the steps of: placing the chiral system to be processed, which is optically enriched by a target enantiomer, in the 3-phase region of the ternary phase diagram of chiral compound forming systems to achieve the establishment of the solid/liquid phase equilibria; phase-separating the liquid and solid phase formed by the placing step; shifting the eutectic composition of the remaining liquid towards a lower eutectic composition (xE) until the overall composition is located in the 2-phase region of the ternary phase diagram of chiral compound forming systems; and performing crystallization in the 2-phase region of the ternary phase diagram for obtaining the target enantiomer in the solid phase. In some cases the shifting step can be skipped.

Abstract: The present invention relates to a green process for purification of free bio amino acids from plant parts, particularly tea leaves and shoots. The invention more particularly relates to an organic solvent free, fast and economical process for purification of natural amino acids on large scale without using any chemical, acid or alkali substance. The invention also relates to a process for purification of bio amino acids from plant and plant parts (renewable bioresources) which are rich in free amino acids.

Abstract: The present invention relates to a method of separating betaine and at least one other component from a sugar beet based fermentation solution. The invention is based on the use of a combination of SAC resins and WAC resins in a specific order and in specified proportions in a chromatographic SMB separation system. The chromatographic separation system is preferably a single integrated SMB system comprising both SAC and WAC resin beds.

Abstract: The object of the present invention is to provide a process for producing refined methionine in which the loss of methionine due to washing is reduced. The present invention relates to a process for producing refined methionine from crude methionine, comprising a step of washing crude methionine with the use of a wash water containing methionine.

Abstract: The invention in some aspects relates to devices and methods for nucleating crystals under controlled conditions. In some aspects of the invention, devices and methods are provided for continuous crystallization.

Abstract: L-valine granules are produced by adding L-glutamic acid to an aqueous solution containing L-valine so that the amount of L-glutamic acid is 0.5% by weight or more relative to the L-valine, dissolving the L-glutamic acid, then adjusting the pH of the aqueous solution to an acidic level and then crystallizing the L-valine.

Abstract: The invention relates to a process for the production of L-carnitine tartrate, wherein the L-carnitine tartrate is precipitated from a reaction mixture comprising L-carnitine and tartaric acid dissolved in ethanol, the ethanol having a water content of less than 5% (w/w).

Abstract: The present invention generally relates to processes for recovery of phosphorus values and salt impurities from aqueous waste streams. In particular, the present invention relates to processes for recovery of phosphorus values and salt impurities from aqueous waste streams generated in the manufacture of phospho-herbicides, including N-(phosphonomethyl)glycine and glufosinate.

Abstract: The invention relates to a method for producing a purified solution containing L-cysteine from a fermentation broth containing L-cysteine. In said method, the fermentation broth containing L-cysteine, at a pH value from pH 6 to 9, is brought in contact with a basic anion exchanger, wherein the L-cysteine bonds to the anion exchanger. The anion exchanger is then rinsed with a first washing solution, and the bonded L-cysteine is removed from the anion exchanger by means of an acid and transferred into an eluate. Said eluate, having a pH?4, is brought in contact with an acidic cation exchanger, wherein the L-cysteine bonds to the cation exchanger. The cation exchanger is rinsed with a second washing solution, and the bonded L-cysteine is removed from the cation exchanger by means of a strong acid.

Abstract: Processes for producing a suitable purity grade of L-Citrulline are disclosed. The processes can include contacting crude L-Citrulline in an aqueous solution with an adsorptive medium at a temperature above approximately 50° C. and below the temperature of denaturement for the L-Citrulline for an interval sufficient to remove at least one contaminant from the L-Citrulline. The processes can also include concentrating the dissolved L-Citrulline relative to the aqueous solution.

Abstract: Subject of the invention is a method for the production of L-carnitine, comprising the steps of (a) providing a solution comprising at least 5% (w/w) carnitine in a first solvent, wherein the carnitine is a mixture of D- and L-carnitine, (b) optionally seeding the solution with L-carnitine crystals, (c) adding an second solvent, in which the L-carnitine is not soluble or has a low solubility, (d) isolating crystals comprising L-carnitine.

Abstract: The present invention relates to an apparatus for continuous separation of valine from the mixture comprising amino acids such as leucine, isoleucine, etc. and a method for continuous separation of valine by using the same, and the present invention can continuously separate valine from the mixture comprising amino acids such as leucine, isoleucine, etc. in a high purity and yield.

Abstract: The present invention provides an improved method for preparing, purifying, precipitating, etc., a subject compound for use in a subsequent reaction carried out in suspension. The present invention relies on a precipitating solvent being added to an aqueous solution comprising the subject compound to form a precipitate of the subject compound, which may be further dried and/or purified. Compositions made according to present methods have improved characteristics and properties, such as increased surface and/or reduced density, resulting in a higher reactivity in a subsequent reaction carried out in suspension.

Abstract: The present invention relates to methods for rapid crystallization of amino acids, drug molecules, proteins and DNA/peptides. One method for rapid crystallization of functional group-containing molecules selected from the group consisting of amino acids, drug molecules, proteins and DNA/peptides includes (A) providing at least one metal or metal oxide in particulate or thin film form to provide (a) selective nucleation sites for crystallization of the functional group-containing molecules due to interactions of their functional groups and metal surfaces or engineered metal surfaces and (b) a microwave-transparent medium to create a thermal gradient between the metal surfaces or engineered metal surfaces and a warmer solution containing functional group-containing molecules to be crystallized, and (B) conducting microwave heating to cause the functional group-containing molecules to be crystallized.

Abstract: The invention relates to the use of solid betaine for de-icing and/or preventing slipperiness. The solid betaine comprises at least one non-betaine compound affecting water and/or moisture movement in said solid betaine. The invention further relates to a process for the manufacture of solid betaine. A suspension comprising betaine crystals is prepared from a feed liquid and the betaine crystals are separated and washed. The amount of wash liquid is adjusted in order to leave 0.5 to 10 w-% of at least one non-betaine compound in said solid betaine.

Abstract: The present invention relates to a method for producing N-protected amino acid. Specifically, the present invention provides a method in which a protecting group is introduced to the amino group of an amino acid in a reaction under alkaline condition, and the N-protected amino acid thus generated is then separated from the reaction solution as crystals, without undergoing an extraction step or a concentration step. The present inventors have completed the invention based on the finding that desirable crystals of N-protected amino acids may be obtained without extraction, concentration or recrystallization steps between the initial generation of the N-protected amino acid molecules and the subsequent separation of the crystals, by first adding an water-soluble organic solvent and optionally water to the reaction solution (alkaline) containing the N-protected amino acid, and then neutralizing the solution by an acid.

Abstract: Processes for producing a suitable purity grade of L-Citrulline are disclosed. The processes can include contacting crude L-Citrulline in an aqueous solution with an adsorptive medium at a temperature above approximately 50° C. and below the temperature of denaturement for the L-Citrulline for an interval sufficient to remove at least one contaminant from the L-Citrulline. The processes can also include concentrating the dissolved L-Citrulline relative to the aqueous solution.

Abstract: A method is provided for concentrating a material solution using at least two consecutive membrane separating stages, each stage for separating the material solution into a retentate and a permeate. The cut-off of the membranes used in the separating stages is higher than that of the membrane used in the previous stage. The retentate of each separating stage, with the exception of the last stage, is fed to the following separating stage as a feed, and the permeate from at least one separating stage is fed back to a preceding separating stage and introduced into the feed thereof. The fed-back permeate has a concentration and viscosity that substantially corresponds to the concentration and viscosity of the preceding separating stage into which the permeate is introduced.

Abstract: A process is disclosed for separating biomolecules from an aqueous solution containing the biomolecules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.

Abstract: A process for producing a cocoa husk extract containing gamma-aminobutyric acid (GABA) is provided, the process comprising: a) extracting GABA and methylxanthines from cocoa husks with an aqueous medium thereby to form an aqueous solution containing GABA and methylxanthines; b) removing at least part of the methylxanthines from the aqueous solution with a solvent which is immiscible with water; and c) retaining the aqueous solution containing the GABA. A cocoa husk extract comprising GABA and methylxanthines wherein the ratio of GABA to methylxanthines is at least 1:20 and a food product containing such an extract are also provided.

Abstract: The present invention relates to a process for the removal of organic acids, particularly naphthenic acids, from crude oils and crude oil distillates by use of a supported basic ionic liquid in a mass ratio of crude oil and/or crude oil distillate and ionic liquid of from greater than 40:1, the basic ionic liquid comprises a basic anion selected from serinate, prolinate, histidinate, threoninate, valinate, asparaginate, taurinate and lysinate.

Abstract: Processes for producing a suitable purity grade of L-Citrulline are disclosed. The processes can include contacting crude L-Citrulline in an aqueous solution with an adsorptive medium at a temperature above approximately 50° C. and below the temperature of denaturement for the L-Citrulline for an interval sufficient to remove at least one contaminant from the L-Citrulline. The processes can also include concentrating the dissolved L-Citrulline relative to the aqueous solution.

Abstract: L-citrulline may be extracted from watermelons using a process which does not require rigorous extraction with alcoholic and/or acidic solvents, or treatment at high temperatures. In the process, the watermelon juice is contacted with an adsorbent effective for adsorption of L-citrulline thereon, and the juice is separated therefrom. The L-citrulline on the adsorbent may then be eluted and recovered. Lycopene-containing microparticles may also be separated from the watermelon juice prior to contact with the adsorbent.

Abstract: A method for producing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate by saponification of salts of 3-(2,2,2-trimethylhydrazinium)propionate esters with subsequent purification step using saturation with carbon dioxide or sulphur dioxide in alcoholic solution.

Abstract: A method for producing crystals of 5-aminolevulinic acid hydrochloride wherein, in carrying out adsorption of 5-aminolevulinic acid contained in a crude 5-aminolevulinic acid solution by a cation exchange resin and its subsequent desorption with an aqueous solution containing ammonium ion, a high purity 5-aminolevulinic acid aqueous solution is obtained using a change in electric conductivity or pH of the desorption liquid as the index, and chloride ion is added to the aqueous solution which is then mixed with an organic solvent.

Abstract: The present invention discloses a process for the recovery of betaines from electrodialysis (ED) waste streams, whereby said waste streams are treated with a pressure driven membrane process.

Abstract: A process for purifying at least one product from a substrate containing at least one product, includes subjecting the substrate to centrifugal partition chromatography in an ion exchange displacement mode to purify the at least one product from the substrate, the at least one product being an amphoteric product.

Abstract: L-cysteine-is separated from an L-cysteine-containing fermenter broth containing an oxidizing agent which is capable of oxidizing L-cysteine at pH<5, by contacting the L-cysteine-containing fermenter broth with an ion exchanger at a pH from 5 to 9, the pH in the fermenter broth becoming <5, and preferably <2. The L-cysteine binds to the ion exchanger and the bound L-cysteine is then removed from the ion exchanger by means of an eluant.

Abstract: Provided is a method for preparing stable free flowing solid aminocarboxylate chelants by adding to a chelant that contains residual alkaline metal hydroxide a free or partially neutralized carboxylic acid such that the free or partially neutralized acid neutralizes at least a portion of the alkaline metal hydroxide; and isolating therefrom the free-flowing solid chelant.

Abstract: Method for enantioseparation of a chiral system with compound formation comprising a pair of enantiomers. The method comprises the steps of: placing the chiral system to be processed, which is optically enriched by a target enantiomer, in the 3-phase region of the ternary phase diagram of chiral compound forming systems to achieve the establishment of the solid/liquid phase equilibria; phase-separating the liquid and solid phase formed by the placing step; shifting the eutectic composition of the remaining liquid towards a lower eutectic composition (xE) until the overall composition is located in the 2-phase region of the ternary phase diagram of chiral compound forming systems; and performing crystallisation in the 2-phase region of the ternary phase diagram for obtaining the target enantiomer in the solid phase. In some cases the shifting step can be skipped.

Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of pregabalin in high yield and purity. The present invention also provides a process for the purification of (S)-pregabalin.

Abstract: The invention relates to a multiprofile chromatographic sequential SMB process of separating and recovering betaine and sucrose from concentrated raw juice or thick juice. In the process of the invention, the betaine subprofile and the residual subprofile of successive separation profiles are overlapping. A sucrose fraction and a betaine fraction containing also residual components are recovered. Betaine is further separated from the betaine fraction for example by chromatographic processes.

Abstract: The invention relates to a three-profile chromatographic sequential SMB process of separating and recovering products such as sugars and betaine from multicomponent feed solutions. In the process of the invention, product fractions and optionally recycle fractions are collected from several positions of the chromatographic separation system. The process of the invention may be applied to the separation of sucrose and betaine from sugar beet based solutions and to the separation of sugars, e.g. xylose, from plant-based hydrolysates, for example.

Abstract: Nateglinide M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2?)) can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble.

Abstract: The invention provides a method of synthesis of N-6-trimethyl-L-lysine (TML) derivative compounds for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method of purification of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent application.

Abstract: The present invention relates to a solid bed adsorptive separation of organic acid and/or amino acids from fermentation broths containing organic acid and/or amino acid.

Abstract: The present invention relates to novel perfluorinated precursors for the production of F-18 labeled radiotracers for Positron Emission Tomography (PET) and processes for radiolabeling and purification using these precursors. The invention also comprises radiopharmaceutical kits using these precursors and processes.

Abstract: Subject of the invention is a method for the production of L-carnitine, comprising the steps of (a) providing a solution comprising at least 5% (w/w) carnitine in a first solvent, wherein the carnitine is a mixture of D- and L-carnitine, (b) optionally seeding the solution with L-carnitine crystals, (c) adding an second solvent, in which the L-carnitine is not soluble or has a low solubility, (d) isolating crystals comprising L-carnitine.

Abstract: Nateglinide M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2?)) can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble.

Abstract: Disclosed is a process for the simple preparation of trifluoromethionine, its analogs trifluoromethylcysteine, fluoroalkylhomocysteines, and fluoroalkylcysteines, and derivatives of them. These compounds are drug-candidate compounds or raw materials of drug-candidate compounds. Specifically, trifluoromethionine, trifluoromethylcysteine, a fluoroalkylhomocysteine, or a fluoroalkylcysteine is simply and conveniently prepared directly without passing through homocysteine or cysteine by adding metallic sodium to an optically active or racemic homocystine or cystine in liquid ammonia and further adding a fluoroalkyl iodide thereto under Birch reduction conditions.

Abstract: The present invention relates to an alkalimetal salt of glutamic acid-N,N-diacetic acid (GLDA) of the formula NaxKyHzGLDA, wherein x is equal to or more than 2 and lower than 4 and y is more than 0 and equal to or lower than 2, x+y is 3.5-4, and x+y+z=4, to processes to prepare such salt and the use thereof.

Abstract: The present invention provides a process for resolving racemic pregabalin to S-pregabalin by using a chiral acid to form a pregabalin salt, purifying the salt to obtain a purified S- pregabalin salt then neutralizing the salt to obtain S-pregabalin having good chiral purity.

Abstract: Betaines of formula R3N+-Q-COO? (I), wherein R is C1-4 alkyl and Q is C1-4 alkanediyl, optionally substituted with hydroxy, are prepared in one step by adding an ?-halocarboxylate of formula X-Q-COOR? (II), wherein Q is as defined above, R? is C11-4 alkyl and X is chlorine, bromine or iodine, to an aqueous solution containing a tertiary amine of formula R3N (III), Wherein R is as defined above and a base selected from alkali hydroxides and alkaline earth hydroxides. The process is particularly suited to the production of L-carnitine.