Citric Acid Per Se Or Salt Thereof Patents (Class 562/584)
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Patent number: 4895980Abstract: A dual mineral salt consisting essentially of magnesium, potassium and citrate. A method for manufacturing the subject salt in a form having a bulk density ranging from about 1.0 g/cc to about 1.3 g/cc is also disclosed, and the use of the subject salt as a dietary supplement are also disclosed.Type: GrantFiled: January 27, 1989Date of Patent: January 23, 1990Assignee: Mission Pharmacal Company, Inc.Inventor: Neill B. Walsdorf
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Patent number: 4855494Abstract: A process for producing citric acid or other suitable acids and/or their salts from fermentation solutions. The process comprises removing high molecular weight impurities by means of membrane filtration and/or addition adsorption on a nonionic adsorption resin and removing low molecular weight impurities by anion and cation exchange and/or precipitating a citric acid as a calcium salt.Type: GrantFiled: February 1, 1985Date of Patent: August 8, 1989Assignee: Joh. A. Benckiser GmbHInventors: Gabriella Margureanu, Friedrich Gutmann
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Patent number: 4820870Abstract: The invention provides a novel acidic alkali citrate having the formula K.sub.6 Na.sub.6 H.sub.3 (C.sub.6 0.sub.7 H.sub.5).sub.5 . 2-4 H.sub.2 O made by dissolving either(a) trisodium citrate.times.2 H.sub.2 O, tripotassium citrate.times.1 H.sub.2 O, and citric acid in a mole ratio of 2:2:1 in 3 to 5 times the quantity by weight of boiling demineralized water, based on the weight of the citric acid and maintaining the solution at a temperature not lower than 60.degree. C.; or(b) citric acid at 90.degree. C. while stirring in .01 to 1 times its weight of demineralized water and then adding sodium carbonate and potassium carbonate to give a mole ratio of 3:3:5 of sodium carbonate: potassium carbonate:citric acid,and quick drying the homogeneous solution obtained. Therapeutic agents for the treatment of urolithiasis and removal, or preventing recurrence, of urine stones comprising said acidic alkali citrate are provided.Type: GrantFiled: April 1, 1987Date of Patent: April 11, 1989Assignee: Dr. Madaus & Co.Inventors: Rolf Madaus, Werner Stumpf, Klaus Gorler, Alfonso Carcasona-Beltran
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Patent number: 4720579Abstract: Citric acid is separated from a fermentation broth by using an adsorbent comprising a neutral, noniogenic, macroreticular, water-insoluble, crosslinked styrene-poly(vinyl)benzene and a desorbent comprising water and, optionally, acetone with the water. The pH of the feed is adjusted and maintained below the first ionization constant (pKa.sub.1) of citric acid to maintain selectivity.Type: GrantFiled: December 18, 1986Date of Patent: January 19, 1988Assignee: UOP Inc.Inventor: Santi Kulprathipanja
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Patent number: 4705894Abstract: A mixture of trialkyl phosphine oxides (HTRPO) was prepared having the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are same or different alkyl groups of 5 to 9 carbon atoms and the total number of carbon atoms and the total number of carbon atoms per molecule is from 15 to 27. The mixture of trialkyl phosphine oxides (HTRPO) is useful as an extractant for recovering acids from aqueous solutions.Type: GrantFiled: March 21, 1986Date of Patent: November 10, 1987Inventors: Yuanfu Su, Yuming Jiang
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Patent number: 4505862Abstract: An analgesic and sleep-aid composition containing an analgesic (e.g. aspirin, APAP or combinations thereof) and diphenhydramine dihydrogencitrate. Discloses several dosage forms including a two layer tablet in which aspirin is contained in one layer and APAP contained in the other layer; the preferred form being such that the diphenhydramine dihydrogencitrate is contained in the APAP layer.Type: GrantFiled: September 13, 1982Date of Patent: March 19, 1985Assignee: Bristol-Myers CompanyInventors: Harold Sheinaus, Arnold D. Marcus
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Patent number: 4444881Abstract: A process is provided for the recovery of organic acids from dilute aqueous solutions. The acid in the form of its calcium salt is treated with a tertiary amine carbonate and the resulting trialkylammonium salt of the acid is isolated and heated to give the acid plus a tertiary amine.Type: GrantFiled: June 27, 1983Date of Patent: April 24, 1984Assignee: CPC International Inc.Inventor: Branko Urbas
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Patent number: 4400535Abstract: The invention provides a novel acidic alkali citrate having the formula K.sub.6 Na.sub.6 H.sub.3 (C.sub.6 O.sub.7 H.sub.5).sub.5.2-4 H.sub.2 O made by dissolving either(a) trisodium citrate.times.2 H.sub.2 O, tripotassium citrate.times.1 H.sub.2 O, and citric acid in a mole ratio of 2:2:1 in 3 to 5 times the quantity by weight of boiling dimineralized water, based on the weight of the citric acid and maintaining the solution at a temperature not lower than 60.degree. C.; or(b) citric acid at 90.degree. C. while stirring in 0.1 to 1 times its weight of demineralized water and then adding sodium carbonate and potassium carbonate to give a mole ratio of 3:3:5 of sodium carbonate:potassium carbonate:citric acid,and quick drying the homogeneous solution obtained. Therapeutic agents for the treatment of urolithiasis and removal, or preventing recurrence, of urine stones comprising said acidic alkali citrate are provided.Type: GrantFiled: January 9, 1981Date of Patent: August 23, 1983Assignee: Dr. Madaus & Co.Inventors: Rolf Madaus, Werner Stumpf, Klaus Gorler, Alfonso Carcasona-Beltran
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Patent number: 4354039Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.Type: GrantFiled: September 21, 1981Date of Patent: October 12, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
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Patent number: 4340754Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.Type: GrantFiled: September 21, 1981Date of Patent: July 20, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
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Patent number: 4334095Abstract: Organic acids, such as citric acid, malic acid and lactic acid, can be extracted from aqueous solutions thereof by contacting such solutions with a mixture of a water immiscible amine and a water immiscible organic acid dissolved in a suitable water immiscible solvent.Type: GrantFiled: October 6, 1980Date of Patent: June 8, 1982Assignee: Miles Laboratories, Inc.Inventor: Avraham M. Baniel
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Patent number: 4324906Abstract: A process is disclosed for converting a compound of the formula ##STR1## wherein R and R" are independently methyl, ethyl or propyl;R' is H, Na, Li, K, Mg.sub.1/2, Ca.sub.1/2, Sr.sub.1/2, Ba.sub.1/2, methyl, ethyl or propyl; andQ is chlorine or bromide;directly to a citrate salt by heating in an aqueous medium, with an alkaline earth metal hydroxide, at a temperature greater than 160.degree. C.Type: GrantFiled: August 20, 1979Date of Patent: April 13, 1982Assignee: Lever Brothers CompanyInventors: Eddie N. Gutierrez, Vincent Lamberti
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Patent number: 4312885Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.Type: GrantFiled: December 26, 1978Date of Patent: January 26, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
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Patent number: 4310691Abstract: A process for recovering sodium citrate from a solution utilized in an absorption/stripping process for SO.sub.2 recovery, which involves cooling a portion of the stripping solution to precipitate sodium sulfate, which is separated from the mother liquor. Thereafter, the mother liquor portion is subjected to an evaporative crystallization to precipitate sodium citrate, which is reintroduced along with fresh absorbent solution into the SO.sub.2 absorption/stripping process.Type: GrantFiled: October 31, 1979Date of Patent: January 12, 1982Assignee: Aktiebolaget Svenska FlaktfabrikenInventors: Sune Bengtsson, Tom Lillestolen
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Patent number: 4308398Abstract: A method of substantially depressing or eliminating reducing sugars present in trisodium citrate is disclosed. The method involves contacting the reducing sugars with a hydroxylamine under neutral or alkaline conditions.Type: GrantFiled: August 4, 1980Date of Patent: December 29, 1981Assignee: Miles Laboratories, Inc.Inventor: Peter J. Borchert
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Patent number: 4275234Abstract: Acids are recovered from their aqueous solution by an extraction process comprising a first extraction stage at which the aqueous solution is contacted with a water-immiscible extractant comprising a water-immiscible organic solvent and, dissolved therein, at least one secondary or tertiary amine in which the aggregate number of carbon atoms is at least 20; and a back-extraction stage in which the organic extract, separated from the original aqueous solution, is stripped with an aqueous liquid at a temperature which is higher by at least 20.degree. C. than the temperature of the first extraction stage. The stripped extractant can be recycled to the first extraction stage for making the process continuous, and if so recycled, is cooled on its way to the extraction stage. A preferred field of application is the recovery of organic acids produced by fermentation from the fermentation broth, e.g. citric acid.Type: GrantFiled: May 31, 1973Date of Patent: June 23, 1981Assignee: Imi (Tami) Institute for Research and DevelopmentInventors: Avraham M. Baniel, Ruth Blumberg, Klara Hajdu
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Patent number: 4251671Abstract: Citric acid can be extracted from aqueous citric acid solutions by contacting such solutions with an N-substituted alkyl amide containing a total of at least twelve carbon atoms.Type: GrantFiled: October 5, 1979Date of Patent: February 17, 1981Assignee: Miles Laboratories, Inc.Inventors: John E. Alter, Ruth Blumberg
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Patent number: 4249018Abstract: Citric acid or a citrate ester can be prepared by the process comprising the steps of oxidizing isotetralin to form cyclodeca-1,6-diene-4,9-dione, converting the dione into the bis-cyanohydrin derivative, ozonating the bis-cyanohydrin and recovering citric acid or a citrate ester. It is preferred that the isotetralin be prepared by reduction of naphthalene.Type: GrantFiled: August 27, 1979Date of Patent: February 3, 1981Assignee: Miles Laboratories, Inc.Inventors: David Ginsburg, Wilfried J. W. Mayer, Allan Wexler