Phosphorus Attached Directly Or Indirectly To The Boron By Nonionic Bonding Patents (Class 562/807)
  • Process for the preparation of onium salts having a low chloride content
    Patent number: 7692007
    Abstract: The invention relates to a process for the preparation of onium salts having a low chloride content by reaction of an onium chloride with an acid, where the hydrochloric acid forming is removed by azeotropic distillation by coordination to an organic solvent which forms an azeotropic mixture with water.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: April 6, 2010
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, Peter Barthen, Helge Willner
  • Production method of citalopram, intermediate therefor and production method of the intermediate
    Publication number: 20040138497
    Abstract: Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula [VI] with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,N′,N′-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula [III], which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula [II] to reduction and cyclization.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Applicant: Sumika Fine Chemicals Co., Ltd.
    Inventors: Tetsuya Ikemoto, Wei-Guo Gao, Masami Igi