Containing Nitrogen Double Bonded Directly To Carbon (e.g., Nitroguanidines, Etc.) Patents (Class 564/108)
-
Patent number: 8633228Abstract: A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group derived from a 5- or 6-membered aromatic ring, in combination with A and two carbon atoms to which A bonds, X represents a hydrogen atom, a halogen atom, or the like, n represents an integer of from 0 to 4, T represents —C(?G1)-Q1 (wherein G1 and G2 represent an oxygen atom or the like, Q1 represents a phenyl group which may have a substituent, a heterocyclic group which may have a substituent, or the like), or the like, Q2 represents a phenyl group or the like, G3 represents an oxygen atom or the like, and R1 and R2 each independently represent a hydrogen atom, a C1-C6 alkyl group, or a group represented by -L-D, or the like (provided that at least either R1 or R2 represents a group represented by -L-D); as an active ingredient exhibits an excellent effect.Type: GrantFiled: June 29, 2009Date of Patent: January 21, 2014Assignee: Mitsui Chemicals Agro, Inc.Inventors: Yumi Kobayashi, Hiroyuki Katsuta, Michikazu Nomura, Hidetaka Tsukada, Atsushi Hirabayashi, Hidenori Daido, Yusuke Takahashi, Shinichi Banba
-
Patent number: 8193247Abstract: Provided are various compounds of Formula (I): Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.Type: GrantFiled: March 23, 2007Date of Patent: June 5, 2012Assignee: The Feinstein Institute for Medical ResearchInventor: Yousef Al-Abed
-
Publication number: 20110306639Abstract: The present invention discloses hydrocarbylidene nitrohydrozinecarboximidamides and the use thereof as well as a method for making the same. The structural general formula of the compounds are shown in formula I, wherein, R1 is C1-C10 saturated and/or unsaturated aliphatic hydrocarbonyl, benzyl, substituted benzyl, halogenated picolyl, halogenated thiazolyl methyl, tetrahydrofuryl methyl or oxazolyl methyl; R2 is hydrogen, C1-C5 saturated and/or unsaturated aliphatic hydrocarbonyl, phenyl, substituted phenyl, pyridyl or substituted pyridyl; R3 is hydrogen, C1-C10 saturated and/or unsaturated aliphatic hydrocarbonyl, furyl, phenyl, substituted phenyl, benzyl or substituted benzyl. The tests of insecticidal activity show that the hydrocarbylidene nitrohydrozinecarboximidamides shown by formula (I) have high preventive efficiency against insect pests of plants, such as aphid, plant hopper, cotton bollworm, asparagus caterpillar, and the like, and can be used as plant insecticides.Type: ApplicationFiled: November 25, 2008Publication date: December 15, 2011Inventors: ZhaoHai Qin, Yongqiang Ma, Wangcang Su, Lei Wang, Zheng Zhang, Bengbin Zhao, Jiangsheng Fang
-
Publication number: 20110136878Abstract: A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group derived from a 5- or 6-membered aromatic ring, in combination with A and two carbon atoms to which A bonds, X represents a hydrogen atom, a halogen atom, or the like, n represents an integer of from 0 to 4, T represents —C(=G1)-Q1 (wherein G1 and G2 represent an oxygen atom or the like, Q1 represents a phenyl group which may have a substituent, a heterocyclic group which may have a substituent, or the like), or the like, Q2 represents a phenyl group or the like, G3 represents an oxygen atom or the like, and R1 and R2 each independently represent a hydrogen atom, a C1-C6 alkyl group, or a group represented by -L-D, or the like (provided that at least either R1 or R2 represents a group represented by -L-D); as an active ingredient exhibits an excellent effect.Type: ApplicationFiled: June 29, 2009Publication date: June 9, 2011Applicant: Mitsui Chemicals Agro., Inc.Inventors: Yumi Kobayashi, Hiroyuki Katsuta, Michikazu Nomura, Hidetaka Tsukada, Atsushi Hirabayashi, Hidenori Daido, Yusuke Takahashi, Shinichi Banba
-
Publication number: 20090221747Abstract: Methods for the separation of targeted components from gun propellant formulations. In particular, the methods separate targeted components in a usable/useful form. Preferred methods are directed to the separation of nitrocellulose, nitroguanidine and/or nitroglycerine from a formulation containing one or more of these components.Type: ApplicationFiled: May 17, 2004Publication date: September 3, 2009Inventors: Nese Orbey, B. Michael Cushman, Marina Temchenko
-
Patent number: 7560593Abstract: Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity.Type: GrantFiled: February 7, 2007Date of Patent: July 14, 2009Assignee: Mitsui Chemicals, Inc.Inventors: Hisato Kamekawa, Toshiyuki Kohno, Hiroyuki Katsuta, Daisuke Ura, Kenichi Satoh
-
Publication number: 20090170951Abstract: Provided are various compounds of Formula (I): Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.Type: ApplicationFiled: March 23, 2007Publication date: July 2, 2009Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCHInventor: Yousef Al-Abed
-
Publication number: 20090018363Abstract: Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity.Type: ApplicationFiled: February 7, 2007Publication date: January 15, 2009Applicant: MITSUI CHEMICALS, INCInventors: Hisato Kamekawa, Toshiyuki Kohno, Hiroyuki Katsuta, Daisuke Ura, Kenichi Satoh
-
Patent number: 6806292Abstract: The present invention relates to novel substituted imide derivatives of the general formula (I) in which R1 represents optionally substituted cycloalkyl, R2 represents optionally substituted alkyl or optionally substituted cycloalkyl, R3 represents alkyl, alkoxy, alkylthio, amino, alkylamino or dialkylamino and R4 represents cyano or nitro, and to processes for their preparation and to their use for controlling animal pests and as herbicides.Type: GrantFiled: July 26, 2002Date of Patent: October 19, 2004Assignee: Bayer AktiengesellschaftInventors: Hans-Jochem Riebel, Stefan Herrmann, Achim Hense, Ernst-Rudolf Gesing, Kristian Kather, Stefan Lehr, Wolfram Andersch, Mark Wilhelm Drewes, Dieter Feucht, Achim Harder
-
Patent number: 6720451Abstract: The present invention relates to a novel process for the preparation of N-methyl-N′-nitroguanidine by reacting nitroguanidine with aqueous methylamine solution buffered by the addition of inorganic or organic acids.Type: GrantFiled: July 9, 2002Date of Patent: April 13, 2004Assignee: Bayer AktiengesellschaftInventors: Kai van Laak, Wolfram Sirges
-
Publication number: 20030236168Abstract: Processes for preparing &agr;-substituted benzylnitroguanidines include the steps of providing a reaction mixture comprising water, alcohol, an S-alkyl nitroisothiourea, and an &agr;-substituted benzylamine; heating the reaction mixture; steam distilling the alcohol from the reaction mixture; and isolating an &agr;-substituted benzylnitroguanidine from the remaining water layer.Type: ApplicationFiled: June 20, 2002Publication date: December 25, 2003Inventors: David M. Mayes, Vijay C. Desai, Eric Rivadeneira
-
Patent number: 6638979Abstract: The present invention relates to novel imidamide derivatives of the formula (I) in which R, R1, R2 and R3 are each as defined in the description, to a process for their preparation and to their use for controlling animal pests, such as insects, arachnids and, in particular, nematodes.Type: GrantFiled: February 5, 2001Date of Patent: October 28, 2003Assignee: Bayer AktiengesellschaftInventors: Hans-Jochem Riebel, Peter Gerdes, Ernst-Rudolf F. Gesing, Achim Hense, Johannes Kanellakopulos, Kristian Kather, Rolf Kirsten, Stefan Lehr, Lothar Rohe, Katharina Voigt, Detleff Wollweber, Wolfram Andersch
-
Publication number: 20030100613Abstract: The present invention relates to novel substituted imide derivatives of the general formula (I) 1Type: ApplicationFiled: July 26, 2002Publication date: May 29, 2003Inventors: Hans-Jochem Riebel, Stefan Herrmann, Achim Hense, Ernst-Rudolf Gesing, Kristian Kather, Stefan Lehr, Wolfram Andersch, Mark Wilhelm Drewes, Dieter Feucht, Achim Harder
-
Publication number: 20030092915Abstract: Method of producing compounds of formula 1Type: ApplicationFiled: December 20, 2002Publication date: May 15, 2003Inventors: Gottfried Seifert, Thomas Rapold, Verena Gisin
-
Publication number: 20030004376Abstract: The present invention relates to a novel process for the preparation of N-methyl-N′-nitroguanidine by reacting nitroguanidine with aqueous methylamine solution buffered by the addition of inorganic or organic acids.Type: ApplicationFiled: July 9, 2002Publication date: January 2, 2003Inventors: Kai Van Laak, Wolfram Sirges
-
Patent number: 6486348Abstract: The invention relates to a method for producing 1-methyl-3-nitroguanidine. According to said method, nitroguanidine is reacted with methylamine and/or a methylammonium salt in an aqueous solution, at temperatures of 30 to 60° C. and at a pH value of 95 to 12.3. In this way, yields of 1-methyl-3-nitroguanidine of at least 80% and degrees of purity>99% can be obtained in a particularly environmentally friendly and technically simple way.Type: GrantFiled: June 5, 2002Date of Patent: November 26, 2002Assignee: Nigu Chemie GmbHInventor: Norbert Kern
-
Publication number: 20020173675Abstract: The invention relates to a method for producing 1-methyl-3-nitroguanidine. According to said method, nitroguanidine is reacted with methylamine and/or a methylammonium salt in an aqueous solution, at temperatures of 30 to 60° C. and at a pH value of 9.5 to 12.3. In this way, yields of 1-methyl-3-nitroguanidine of at least 80% and degrees of purity >99% can be obtained in a particularly environmentally friendly and technically simple way.Type: ApplicationFiled: June 5, 2002Publication date: November 21, 2002Inventor: Norbert Kern
-
Patent number: 6384277Abstract: The invention relates to a method of producing N-alkyl-N′-nitroguanidine. According to said method, an alkyl amine solution is added to a nitroguanidine or nitroguanidine nitrate suspension at temperatures of >60° C. and the ammonia formed is removed.Type: GrantFiled: September 7, 2001Date of Patent: May 7, 2002Assignee: Dynamit Nobel GmbH Explosivstoff- und SystemtechnikInventors: Winfried Pabst, Rainer Schirra
-
Patent number: 6255512Abstract: Novel compounds are provided having the structural formula R[—N(NO2)—L—R1]n wherein R, L, R1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high energy oxidizing agents in explosive compositions, propellant formulations, gas-generating compositions and the like. The compounds are also useful as pharmaceutical agents. Compositions containing the compounds are also provided, including energetic compositions, as are methods for using the novel compounds and compositions.Type: GrantFiled: October 7, 1999Date of Patent: July 3, 2001Assignee: SRI InternationalInventors: Jeffrey C. Bottaro, Robert J. Schmitt, Mark A. Petrie, Paul E. Penwell
-
Patent number: 6114581Abstract: The invention relates to a novel process for the preparation of N-alkyl-N'-nitroguanidines of the formula (I) ##STR1## in which R is C.sub.1 -C.sub.6 -alkyl,by neutralizing alkylamine with nitric acid, then reacting it with cyanamide, and dehydrating the alkylguanidine nitrate formed.Type: GrantFiled: September 22, 1999Date of Patent: September 5, 2000Assignee: Bayer AktiengesellschaftInventor: Reinhard Lantzsch
-
Patent number: 5789617Abstract: This invention relates to novel neopentyl difluoroamino compounds which are useful as plasticizers and oxidizers in energetic formulations, such as propellants, explosives, and gasifiers. These neopentyl difluoroamino compounds can be prepared either: (1) by the direct fluorination of amine derivatives containing energetic pendant groups; or (2) by first preparing NF.sub.2 -derivatives and then substituting these derivatives with energetic pendant groups. In particular, mono- and bis-(difluoroaminomethyl) oxetanes are synthesized and further reacted to yield the corresponding dinitrate esters. It has been discovered that these NF.sub.2 -dinitrate esters are very useful as energetic plasticizers in high-energy formulations.Type: GrantFiled: September 2, 1992Date of Patent: August 4, 1998Assignee: Aerojet-General CorporationInventors: Thomas G. Archibald, Gerald E. Manser
-
Patent number: 5783734Abstract: The present invention relates to a novel process for preparing N-methyl-N'-nitroguanidine by reacting nitroguanidine with aqueous methylamine solution at 0.degree. to 40.degree. C.Type: GrantFiled: March 18, 1997Date of Patent: July 21, 1998Assignee: Bayer AktiengesellschaftInventors: Bernd Gallenkamp, Lothar Rohe
-
Patent number: 5478946Abstract: Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.Type: GrantFiled: November 30, 1993Date of Patent: December 26, 1995Assignee: Abbott LaboratoriesInventors: Ferid Murad, James F. Kerwin, Lee D. Gorsky
-
Patent number: 5380945Abstract: Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.Type: GrantFiled: November 30, 1993Date of Patent: January 10, 1995Assignee: Abbott LaboratoriesInventors: Ferid Murad, James F. Kerwin, Lee D. Gorsky
-
Patent number: 5360478Abstract: Disclosed is a method for recrystallizing solid materials (e.g. RDX) from systems comprised of a solute, which is the eventual material recrystallized, a liquid which is a suitable solvent for the solute, and a gaseous component which is soluble within the solvent and whose presence therein causes the solvent to approach or attain a supersaturated state, thereby precipitating (recrystallizing) the solute material. By control of process parameters (pressure, temperature, time, and rate, rate of injection of gas, etc.) the operator can influence the properties of the material recrystallized.Type: GrantFiled: June 28, 1991Date of Patent: November 1, 1994Assignee: Phasex CorporationInventors: Val J. Krukonis, P. M. Gallagher, M. P. Coffey
-
Patent number: 5024994Abstract: The invention concerns novel renin-inhibitory peptides which are useful for treating renin-assocated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.Type: GrantFiled: August 17, 1988Date of Patent: June 18, 1991Assignee: Warner-Lambert CompanyInventors: Annette M. Doherty, James P. Hudspeth, James S. Kaltenbronn, Joseph T. Repine, William H. Roark, Ila Sircar, Francis J. Tinney
-
Patent number: 5021429Abstract: Compounds of the general formula: ##STR1## and physiologically acceptable salts, and hydrates, N-oxides and bioprecursors of such compounds and such salts in whichR.sub.1 and R.sub.2, which may be the same or different, represent hydrogen or lower alkyl, cycloalkyl, aralkyl or lower alkenyl groups, or lower alkyl groups interrupted by an oxygen atom or a group ##STR2## in which R.sub.4 represents hydrogen or lower alkyl; or R.sub.1 and R.sub.2 may, together with the nitrogen atom to which they are attached form a heterocyclic ring which may contain the hetero functions --O-- and ##STR3## R.sub.3 represents hydrogen, lower alkyl, alkenyl or alkoxyalkyl; X represents --O--, --S-- or --CH.sub.2 -- or ##STR4## where R.sub.5 is hydrogen or lower alkyl; Y represents .dbd.S, .dbd.O, .dbd.NR.sub.6 or .dbd.CHR.sub.7 ;in which R.sub.6 represents hydrogen, nitro, cyano, lower alkyl, aryl, arylsulphonyl or lower alkylsulphonyl; R.sub.Type: GrantFiled: December 22, 1986Date of Patent: June 4, 1991Assignee: Allen & Hansburys LimitedInventor: Michael Martin-Smith
-
Patent number: 4804780Abstract: Novel substituted phenyl and benzyl nitroguanidine and phenyl and benzyl cyanoguanidine compounds. Methods for increasing crop yield, inhibiting lodging of graminaceous crops, and inducing cytokinin-like responses in crop plants with said novel guanidine compounds and derivatives thereof, as well as methods for inhibiting deterioration and/or extending the shelf life of harvested fruit, vegetables, and ornamentals are disclosed.Type: GrantFiled: March 3, 1986Date of Patent: February 14, 1989Assignee: American Cyanamid CompanyInventors: Laurine M. Speltz, Bryant L. Walworth, Alexander D. Pavlista
-
Patent number: 4677226Abstract: There are provided novel branched alkenylnitroguanidine compounds. A method for inducing cytokinin plant growth regulant activity in crop plants by applying to the crop plants certain alkyl-, alkenyl- and alkynylnitroguanidine compounds is provided.Type: GrantFiled: July 29, 1985Date of Patent: June 30, 1987Assignee: American Cyanamid CompanyInventors: Albert W. Lutz, Shirley J. Rodaway
-
Patent number: 4594092Abstract: Novel substituted phenyl and benzyl nitroguanidine and phenyl and benzyl cyanoguanidine compounds. Methods for increasing crop yield, inhibiting lodging of graminaceous crops, and inducing cytokinin-like responses in crop plants with said novel guanidine compounds and derivatives thereof, as well as methods for inhibiting deterioration and/or extending the shelf life of harvested fruit, vegetables, and ornamentals are disclosed.Type: GrantFiled: November 17, 1983Date of Patent: June 10, 1986Assignee: American Cyanamid CompanyInventors: Laurine M. Speltz, Bryant L. Walworth, Alexander D. Pavlista
-
Patent number: 4568694Abstract: Cystamine derivatives of the formula: ##STR1## [wherein n represents 2 or 3, R.sup.1 and R.sup.2 each represents a hydrogen atom, or an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represents a cycloalkyl or aryl group, and X.sup.1 represents a group selected from the formulae .dbd.N--CN, .dbd.N--NO.sub.2, .dbd.N--COR.sup.3, .dbd.N--COOR.sup.3, .dbd.N--NH--CONH.sub.2, .dbd.N--SO.sub.2 R.sup.3, .dbd.CH--NO.sub.2, .dbd.CH--SO.sub.2 R.sup.3, .dbd.C(CN).sub.2, .dbd.C(CN)COOR.sup.3 and .dbd.C(CN)CONH.sub.2 (wherein R.sup.3 represents an alkyl or aryl group), or R.sup.1 represents a hydrogen atom, R.sup.2 represents an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represents a cycloalkyl or aryl group and X.sup.1 represents an oxygen or sulphur atom] have been found to be useful in the promotion of the growth of non-human animals including birds.Type: GrantFiled: June 15, 1983Date of Patent: February 4, 1986Assignee: May & Baker LimitedInventors: Richard M. Griffin, Malcolm N. Palfreyman
-
Patent number: 4564695Abstract: An N.sup..alpha. -protected-N.sup.G -protected-arginyl-p-nitro-anilide with high purity can be produced in high yield by reacting an N.sup..alpha. -protected-N.sup.G -protected-arginine with p-nitroaniline in pyridine in the presence of a condensing agent.Type: GrantFiled: September 13, 1984Date of Patent: January 14, 1986Assignee: Nitto Boseki Co., Ltd.Inventors: Katsumasa Kuroiwa, Shuichi Nakatsuyama, Takeshi Nagasawa
-
Patent number: 4427685Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: a is 1 to 3;b is 0 to 2;c is 2 to 4;d is 1 to 5;X is sulphur, oxygen or --CH.sub.2 --;Y is oxygen, sulphur, NR.sub.4 or CHR.sub.5 wherein R.sub.4 is hydrogen, C.sub.1-4 alkyl, NO.sub.2 or CN, C.sub.1-4 alkylsulphonyl or phenylsulphonyl optionally substituted in the phenyl moiety by one or two substituents selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, fluorine, chlorine or bromine, and R.sub.5 is NO.sub.2, C.sub.1-4 alkylsulphonyl or optionally substituted phenylsulphonyl as defined for R.sub.4 ;R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-4 alkyl, or C.sub.3-6 cycloalkyl; or R.sub.1 and R.sub.2 taken together with the nitrogen to which they are attached represent a pyrrolidino or piperidino ring;R.sub.6 and R.sub.7 are independently hydrogen or C.sub.Type: GrantFiled: February 3, 1982Date of Patent: January 24, 1984Assignee: Beecham Group P.L.C.Inventor: Geoffrey Stemp
-
Patent number: 4317819Abstract: The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.Type: GrantFiled: December 5, 1980Date of Patent: March 2, 1982Assignee: Glaxo Group LimitedInventors: John W. Clitherow, Barry J. Price, John Bradshaw, Michael Martin-Smith
-
Patent number: 4264614Abstract: The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, =CHNO.sub.2 or =NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.Type: GrantFiled: November 16, 1979Date of Patent: April 28, 1981Assignee: Glaxo Group LimitedInventors: John W. Clitherow, Barry J. Price, John Bradshaw