Phosphorus Attached Directly To Amino Nitrogen By Nonionic Bonding Patents (Class 564/12)
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Patent number: 7183059Abstract: A method of generating a compound having at least one biological activity of a peptide. The method includes identifying a biologically active peptide, providing a first monomer which contains terminal reactive moieties and at least one functionalizable group, providing a second monomer which contains terminal reactive moieties and at least one functionalizable group, and reacting first and second monomer under stereo-and/or regiochemically controlled conditions to yield a compound in which the monomers are attached by way of terminal reactive moieties.Type: GrantFiled: September 7, 2001Date of Patent: February 27, 2007Assignee: President and Fellows of Harvard CollegeInventors: Gregory L. Verdine, Milan Chytil, Mary T. Didiuk, Tiffany Malinky
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Patent number: 7077976Abstract: The invention is a water treatment composition comprising at least one phosphonamide and blends thereof and a method to treat water. As phosphonamides are generally odorless, and typically solids, phosphonamide and phosphonamide blend compositions are generally odorless, conveniently processed and manufactured, and safely used without risks of exposure to odors and vapors associated with the corresponding amines. Advantageously, phosphonamides blended with amino-phosphate esters provide useful treatment compositions. The inventive compositions are generally used to treat water contained in water flow systems such as boilers and cooling towers.Type: GrantFiled: October 25, 2005Date of Patent: July 18, 2006Assignee: JohnsonDiversey, Inc.Inventors: Lyle Steimel, James Emerson, Sue Ann Balow
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Patent number: 6969528Abstract: The invention concerns phosphorus-containing dendrimers and their uses, as gene transfection agents, in vitro and in vivo, including in the treatment of human and animal diseases. These agents or vectors are in particular suited for delivering to appropriate target cells, nucleic acid sequences of interest.Type: GrantFiled: November 23, 2000Date of Patent: November 29, 2005Assignee: Centre National de La Recherche Scientifique-CNRSInventors: Jean-Pierre Majoral, Bernard Meunier, Anne-Marie Caminade, Christophe Loup, Maria-Antonietta Zanta-Boussif
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Patent number: 6906212Abstract: Disclosed are novel phosphine-phosphoramidite compounds which may be employed in combination with a catalytically-active metal to effect a wide variety of reactions such as asymmetric hydrogenations, asymmetric reductions, asymmetric hydroborations, asymmetric olefin isomerizations, asymmetric hydrosilations, asymmetric allylations, asymmetric conjugate additions, and asymmetric organometallic additions. Also disclosed are a process for the preparation of the phosphine-phosphoramidite compounds, metal complex compounds comprising at least one of the phosphine-phosphoramidite compounds and a catalytically-active metal and hydrogenation processes utilizing the metal complex compounds.Type: GrantFiled: June 25, 2004Date of Patent: June 14, 2005Assignee: Eastman Chemical CompanyInventor: Neil Warren Boaz
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Patent number: 6900352Abstract: A novel class of chiral phosphine ligands useful for producing catalyst for asymmetric reactions with general structure of Formula 1:Type: GrantFiled: February 25, 2003Date of Patent: May 31, 2005Assignee: Advanced SynTech, LLCInventors: Zeng Fu Wang, Kexin Yang, Boliang Lou
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Patent number: 6863846Abstract: A description is given of a combustion retardant for polymer materials in the form of a new complex compound of the ammonium salt of amide of alkylphosphonic acid with ammonium chloride, and also of processes for producing various polymer materials using the said combustion retardant.Type: GrantFiled: August 2, 1999Date of Patent: March 8, 2005Assignee: Isle Firestop LimitedInventors: Nina Sergeevna Zubkova, Nataliya Grigorievna Butylkina, Nikolai Alexandrovich Khalturinsky, Alexandr Alexandrovich Berlin
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Patent number: 6855849Abstract: Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.Type: GrantFiled: September 18, 2002Date of Patent: February 15, 2005Assignee: Warner-Lambert CompanyInventors: Garrett Stewart Hoge, II, Om Prakash Goel
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Publication number: 20040259987Abstract: A flame retardant predominantly of polymeric materials, appearing as a novel chemical compound, viz, ammonium salt of nitrolotris(methylene)phosphonic acid amide.Type: ApplicationFiled: March 24, 2004Publication date: December 23, 2004Inventors: Nina S. Zubkova, Nataliya G. Butylkina
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Publication number: 20040147489Abstract: The present invention relates to a novel class of androgen receptor targeting agents (ARTA), which contain a haloacetamide or azide moiety and are alkylating agents.Type: ApplicationFiled: February 24, 2003Publication date: July 29, 2004Inventors: James T. Dalton, Duane D. Miller
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Patent number: 6756500Abstract: A process for preparing a cyclic compound comprising subjecting a starting material in the presence of a catalyst component to metathesis reaction in the presence of an ionic liquid, wherein the starting material is a &agr;,&ohgr;-diene bearing a &agr; substituent NRR1 in the &agr; position to a double bond, wherein R is hydrogen or an organic substituent, R1 is tert-butyl, P(R)2, P(R2)2, COR, SO2PhR, COOR or CONRR2, R2is alkyl or phenyl, or R and R1 together form and in which &agr;,&ohgr;-dienes optionally bear at least one further substituent R in any other position with the exception of the &agr; position, wherein R is selected from the group consisting of hydrogen, fused or unfused aryl, alkyl, CN, COOR2 or halogen, and wherein the starting material optionally contains a member selected from the group containing at least one further substituent that is inert in the metathesis reaction and a heteroatom selected from the group consisting of branched alkyl radicals, unbranched alkyl radicalType: GrantFiled: February 25, 2000Date of Patent: June 29, 2004Assignee: Bayer AktiengesellschaftInventors: Christoph Gürtler, Manfred Jautelat
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Publication number: 20040082547Abstract: The present invention relates to compounds of the Formula 1Type: ApplicationFiled: November 20, 2003Publication date: April 29, 2004Inventors: Seven Nerdinger, Thilo Fuchs, Katrin Illgen, Robert Eckl
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Patent number: 6720442Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P-L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P-L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.Type: GrantFiled: January 15, 2003Date of Patent: April 13, 2004Assignee: SRI InternationalInventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Wolf Eilenberg
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Patent number: 6717011Abstract: The application relates to diazaphospholidine compounds of Formula 1 and Formula 2: where: A and B are independently selected from C(R22R23) and C(R22R23)C(R24R25); R1, R2, R3, R4, R18, R19, R20, R21, R22, R23, R24 and R25 each may not be present and each may be independently selected from H, halide —OH, —SO2R26 (where R26 is selected from a group as defined for R22, R23, R24 and R25), —SH, —NO2, —NH2, ═O, ═S, straight chain, branched chain, cyclic, saturated, non-saturated, substituted or non-substituted alkyl, hydroalkyl, carboalkyl, alkoxy, amino, alkenyl, aryl and —CH2 Ar (where Ar is aryl or substituted aryl), preferably containing 1 to 6 carbons, or a silane containing 1 to 6 silicon atoms, wherein, where an R1, R2, R3, R4, R18, R19, R20, R21, R22, R23, R24 and/or R25 group is not present an unsaturated bond is formed; R5 and R17 are selected from H, —NH2, —OH, halide or a substituted or non-substituted straiType: GrantFiled: December 12, 2001Date of Patent: April 6, 2004Assignee: Stylacats LimitedInventors: Martin Wills, Simon William Breeden
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Publication number: 20040054178Abstract: The invention relates to 1,7-diarylpentamethine and 1,9-diarylheptamethine salts, in partricular heptacarbon or nonacarbon carboxonium salts, and streptocyanines.Type: ApplicationFiled: June 6, 2003Publication date: March 18, 2004Inventors: Yves Madaule, Corrine Payrastre, Albert Izquierdo
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Patent number: 6696608Abstract: A catalytic transfer hydrogenation process is provided. The process can be employed to transfer hydrogenate N-substituted imines and iminium salts, which are preferably prochiral. The catalyst employed in the process is preferably a metal complex with one hydrocarbyl or cyclopentadienyl ligand and which is also coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centres. The hydrogen donor is advantageously a mixture of triethylamine and formic acid. A process for the production of primary and secondary amines using the catalytic transfer hydrogenation of the N-substituted imines and iminium salts is also provided.Type: GrantFiled: February 14, 2002Date of Patent: February 24, 2004Assignee: Avecia LimitedInventors: Juliette Martin, Lynne Alison Campbell
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Publication number: 20040029723Abstract: The present invention relates to compounds of the formula 1Type: ApplicationFiled: August 1, 2003Publication date: February 12, 2004Applicant: Clariant GmbHInventors: Berthold Schiemenz, Thomas Wessel, Ralf Pfirmann
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Publication number: 20030225244Abstract: The present invention provides a novel salt useful as an active species in an organic reaction and represented by the following chemical formula (1): 1Type: ApplicationFiled: June 11, 2003Publication date: December 4, 2003Applicant: Mitsui Chemicals, Inc.Inventors: Tadahito Nobori, Masahiro Kouno, Toshiaki Suzuki, Kazumi Mizutani, Shinji Kiyono, Yoshiho Sonobe, Usaji Takaki
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Patent number: 6635783Abstract: Bicyclic amino alcohols, whose amino group and hydroxy group are bonded in positions 1,3 adjacent to the bridge, for example are valuable ligands for metal complexes of the d-8 metals of the periodic table of elements. The metal complexes in question are catalysts or catalyst precursors for the asymmetric hydrogenation or asymmetric transfer hydrogenation with hydrogen donors of prochiral organic compounds with carbon double bonds or carbon/hetero atom double bonds, for example ketones and imines.Type: GrantFiled: March 6, 2001Date of Patent: October 21, 2003Assignee: Solvias AGInventor: Peter Herold
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Publication number: 20030175597Abstract: The present invention provides an additive which is able to make a non-aqueous-electrolyte secondary cell or a non-aqueous electrolyte electric double layer capacitor which is excellent in low-temperature characteristics, while maintaining a necessary cell properties, and a non-aqueous-electrolyte secondary cell or a non-aqueous electrolyte electric double layer capacitor that contains therein the additive.Type: ApplicationFiled: March 31, 2003Publication date: September 18, 2003Inventors: Masashi Otsuki, Shigeki Endo, Takao Ogino
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Publication number: 20030109754Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P-L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P-L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.Type: ApplicationFiled: January 15, 2003Publication date: June 12, 2003Inventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Wolf Eilenberg, Ursula Eilenberg-Robben
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Patent number: 6555227Abstract: Combination compounds from curing agents/accelerators and flame-protection agents for the latent curing/acceleration of epoxide resin systems and their endowment with flame-retarding properties, the epoxide resin systems being able to be thermally cured, as well as the products prepared from the epoxide resin systems.Type: GrantFiled: February 2, 2001Date of Patent: April 29, 2003Assignee: Schill & Seilacher (GmbH & Co.)Inventors: Stephan Sprenger, Rainer Utz, Michael Ciesielski, Manfred Doering
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Patent number: 6548567Abstract: The invention relates to an ionic compound corresponding to the formula [R1X1(Z1)—Q−—X2(Z2)—R2]m Mm+ in which Mm+ is a cation of valency m, each of the groups Xi is S═Z3, S═Z4, P—R3 or P—R4; Q is N, CR5, CCN or CSO2R5, each of the groups Zi is ═O, ═NC≡N, ═C(C≡N)2, ═NS(═Z)2R6 or ═C[S(═Z)2R6]2, each of the groups Ri, is Y, YO—, YS—, Y2N— or F, Y represents a monovalent organic radical or alternatively Y is a repeating unit of a polymeric frame. The compounds are useful for producing ion conducting materials or electrolytes, as catalysts and for doping polymers.Type: GrantFiled: August 17, 2001Date of Patent: April 15, 2003Inventors: Michel Armand, Christophe Michot, Yurii Yagupolskii, Lev Yagupolskii, Andrej Bezdudny, Natalya Kondratenko
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Publication number: 20030065208Abstract: Provided are a novel triphenyl phosphine derivative synthesized from a triphenylphosphine and a hydroxy-containing lactone; a palladium and a nickel complexes comprising the derivative as a ligand; and a process for preparing a biaryl derivative using the complex as a catalyst. A product can be easily separated from a catalyst or a phosphorus compound, and biaryl derivative can be synthesized in a higher yield, by using the complex of the present invention as a catalyst.Type: ApplicationFiled: September 13, 2002Publication date: April 3, 2003Inventor: Norio Miyaura
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Publication number: 20020183561Abstract: The invention is directed to a process for preparing a polyether polyol by the polyaddition of an alkylene oxide on to a starter compound containing active hydrogen atoms under basic catalysis in the presence of phosphonium cations.Type: ApplicationFiled: May 1, 2002Publication date: December 5, 2002Inventors: Ornulf Rexin, Rolf Mulhaupt
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Publication number: 20020161227Abstract: A substituted aromatic compound substituted with Q is obtained by reacting a phosphazenium compound represented by formula (1) 1Type: ApplicationFiled: December 20, 2001Publication date: October 31, 2002Inventors: Tadahito Nobori, Setsuko Fujiyoshi, Isao Hara, Takaomi Hayashi, Atsushi Shibahara, Katsuhiko Funaki, Kazumi Mizutani, Shinji Kiyono
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Publication number: 20020156295Abstract: One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.Type: ApplicationFiled: October 23, 2001Publication date: October 24, 2002Inventors: Stephen L. Buchwald, David W. Old, John P. Wolfe, Michael Palucki, Ken Kamikawa
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Patent number: 6458292Abstract: A composition for an anti-scale-forming agent includes oil-based polyalkylenes, amines phosphorous and oxygen in a polymer for providing dispersivity and anti-oxidation and having the following formula: By integrating both characteristics into a single polymer, the anti-scale-forming agent in accordance with the present invention can be used as an anti-scale-forming agent for a manufacturing process in a petroleum refinery plant or the like chemistry factory. R1, R2 and x are defined herein.Type: GrantFiled: October 12, 2000Date of Patent: October 1, 2002Assignee: Chinese Petroleum Corp.Inventors: Jiang-Jen Lin, Jann-Chen Lin, Wen-Hen L{dot over (o)}, Wen-Shwong Hwang, Kun-Hai Lin
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Publication number: 20020132851Abstract: A series of substituted sulfonamide derivatives have been prepared and may be used to treat antiviral infections, especially infections caused by orthopoxviruses.Type: ApplicationFiled: July 2, 2001Publication date: September 19, 2002Inventor: Vassil Stefanov Georgiev
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Publication number: 20020128208Abstract: The disclosed invention is a composition agonists and/or antagonists of V2, V1a or both receptors, in a host, including animals, and especially humans, using a small molecule or its pharmaceutically acceptable salt or prodrug.Type: ApplicationFiled: December 17, 2001Publication date: September 12, 2002Inventors: James P. Snyder, Dennis C. Liotta, Hariharan Venkatesan, Minmin Wang, Matthew C. Davis
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Patent number: 6399805Abstract: Compounds of the formula I R1 and R2 independently of one another are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 independently of one another are hydrogen, C1-C20alkyl, OR1 or halogen; R6, R7, R8, R9 and R10 independently of one another are hydrogen, C1-C20alkyl; C2-C20alkyl which is interrupted once or more than once by nonconsecutive O atoms and which is unsubstituted or substituted by OH and/or SH; or R6, R7, R8, R9 and R10 are OR11, SR11, N(R12)(R13), phenyl or halogen; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl which is interrupted once or more than once by O or S and which is unsubstituted or substituted by OH and/or SH; R12 and R13 independently of one another are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl which is interrupted once or more than once by nonconsecutive O atoms and which is unsubstituted or substituted by OH and/or SH; or R12 and R13 together are C3-C5alkylene which can be interrupted by O, S or NR14; R14 is hydrogType: GrantFiled: February 5, 2001Date of Patent: June 4, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Pierre Wolf, Beat Michael Aebli, Gebhard Hug
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Publication number: 20020055651Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: ApplicationFiled: August 21, 2001Publication date: May 9, 2002Inventors: Edmund J. Moran, John H. Griffin, Seok-Ki Choi
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Patent number: 6384261Abstract: Phosphoramidates and phosphinic amides and related compounds are provided. Also provided are methods that use the compounds for modulating the activity of the endothelin family of peptides are provided. In particular, compounds having formula: in which A, B, R1 and R2 are as described are provided. Also provided are methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these compounds or prodrugs thereof. Methods for elucidating the physiological and pathophysiological roles of endothelin, as well as isolating endothelin receptors are also provided.Type: GrantFiled: September 3, 1998Date of Patent: May 7, 2002Assignee: Texas Biotechnology CorporationInventors: Ming Fai Chan, Erik Joel Verner
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Patent number: 6348612Abstract: Novel chiral amidophosphine-phosphinite compounds, which are present in (R) and (S) form, of the general formula wherein R1 signifies alkyl, cycloalkyl or aralkyl, R2 signifies alkyl, cycloalkyl, aralkyl or aryl and R3 and R4 each independently signify alkyl, cycloalkyl, aralkyl, aryl or heteroaryl or R3 and R4 together with the respective phosphorus atom signify a 9-dibenzophospholyl, 9-phosphabicyclo[3.3.1]nonyl or 9-phosphabicyclo[4.2.1]nonyl group and * denotes a chiral center, are manufactured by reacting a compound of the general formula R1C(OH)—CONHR2 (III) with a disubstituted chlorophosphane of the general formula R3R4PCl (IV) in a solvent and in the presence of a base.Type: GrantFiled: March 5, 1998Date of Patent: February 19, 2002Assignee: Roche Vitamins Inc.Inventors: Wolfgang Burkart, Michelangelo Scalone, Rudolf Schmid
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Publication number: 20020016504Abstract: To provide a process for preparing phosphine oxides comprising reacting iminophosphoranes with phosphorus oxytrichloride by which highly purified phosphine oxides can be obtained industrially in a higher yield.Type: ApplicationFiled: August 24, 2001Publication date: February 7, 2002Inventors: Tadahito Nobori, Isao Hara, Katsuhiko Funaki, Takaomi Hayashi, Atsushi Shibahara, Shinji Kiyono, Kazumi Mizutani, Usaji Takaki
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Publication number: 20010047110Abstract: The invention provides a metal complex comprising a ligand and a metal.Type: ApplicationFiled: June 7, 2001Publication date: November 29, 2001Applicant: Takasago International CorporationInventors: Sumi Kenzo, Noyori Ryoji, Ikariya Takao
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Patent number: 6222032Abstract: In a process for C-alkylation or N-alkylation, the improvement comprising conducting the C-alkylation or N-alkylation reaction in the presence of a slightly nucleophilic strong base of the following formula wherein R′1, R′2 and R′3 are individually selected from the group consisting of alkoxy of 1 to 6 carbon atoms and R′ and R″ are individually selected from the group consisting of unsubstituted or substituted alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aryl and aralkyl of 1 to 6 alkyl carbon atoms, the substituents being selected from the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, —CN, —NO2 and dialkylamino of 1 to 6 alkyl carbon atoms, the aryl being selected from the group consisting of unsaturated monocyclic and condensed carbocyclic and heterocyclic with at least one heteroatom selected from the group consisting of nitrogen, oxyType: GrantFiled: November 4, 1999Date of Patent: April 24, 2001Assignees: Societe de Conseils de Recherches d'Applications Scientifiques (SCRAS), Centre National de la Recherche Scientifique (CNRS)Inventors: Guy Bertrand, Dennis Bigg, Jean-Bernard Cazaux, Stéphanie Goumri, Olivier Guerret
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Patent number: 6222072Abstract: A novel process for producing an optically active amine is provided. The optically active amine is adapted for use as an intermediate in synthesizing physiologically active compounds such as pharmaceuticals and agricultural chemicals, as a functional material such as a liquid crystal, and as a starting material in synthesizing fine chemicals. The process comprises the step of reacting an imine with a hydride reagent in the presence of an optically active metal compound and an alcohol compound and/or carboxylic acid compound.Type: GrantFiled: November 6, 1998Date of Patent: April 24, 2001Assignee: Mitsui Chemicals Inc.Inventors: Teruaki Mukaiyama, Kiyoaki Sugi, Takushi Nagata, Toru Yamada
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Patent number: 6177593Abstract: The compound [tris(dimethylamino)phosphonioamino]tris[tris(dimethylamino)phosphoranylideneamino]phosphonium dichloride can be prepared by contacting hydrogen chloride with tetrakis[tris(dimethylamino)phosphoranylideneamino]phosphonium chloride. The phosphonium dichloride compound can be used in a process wherein it is brought into contact with an OH−-form ion exchange resin to prepare tetrakis[tris(dimethylamino)phosphoranylideneamino]phosphonium hydroxide. Separate processes for separating or isolating the phosphonium chloride compound or isolating the phosphonium hydroxide compound from feed solutions wherein an extraction step is used are also set forth.Type: GrantFiled: December 21, 1998Date of Patent: January 23, 2001Assignee: Mitsui Chemicals, Inc.Inventors: Tadahito Nobori, Takaomi Hayashi, Katsuhiko Funaki, Atsushi Shibahara, Isao Hara, Shinji Kiyono, Kazumi Mizutani, Usaji Takaki
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Patent number: 6137012Abstract: Novel reactions used to prepare phosphole and bisphosphole compounds are detailed. Novel phosphole compounds and metal coordination compounds of phosphole and bisphosphole compounds are also provided. These metal coordination compounds are useful as catalysts for the polymerization or olefins with carbon monoxide and for the polymerization of acrylic monomers.Type: GrantFiled: October 8, 1999Date of Patent: October 24, 2000Assignee: E. I. du Pont de Nemours and CompanyInventors: Paul J. Fagan, George Yanwu Li, Zhibin Guan, Lin Wang
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Patent number: 6090980Abstract: A process is provided for preparing iminotris(dimethylamino)phosphorane at high purity and high yield from aminotris(dimethylamino)phosphonium chloride. Aminotris(dimethylamino)phosphonium chloride is first reacted with an aqueous solution of the hydroxide of an alkali metal or alkaline earth metal in the presence of a solvent in which the chloride and hydroxide of the alkali metal or alkaline earth metal are sparingly soluble, whereby iminotris(dimethylamino)phosphorane is formed. After water is dissolved off at a temperature of 70.degree. C. or lower from the reaction mixture, solids are removed from the thus-concentrated reaction mixture by solid-liquid separation. The resultant mother liquor is then distilled to obtain iminotris(dimethylamino)phosphorane.Type: GrantFiled: December 1, 1998Date of Patent: July 18, 2000Assignee: Mitsui Chemicals, Inc.Inventors: Tadahito Nobori, Takaomi Hayashi, Katsuhiko Funaki, Atsushi Shibahara, Isao Hara, Shinji Kiyono, Kazumi Mizutani, Usaji Takaki
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Patent number: 6046358Abstract: Impure tetra(dihydrocarbylamino)phosphonium halide is contacted with a liquid cyclic ether to dissolve the phosphonium halide and leave at least a portion of the impurities comprising at least quaternary ammonium halide or an amidophosphoxide remaining in the solid state. The solids and the liquid phase are separated from each other, an anhydrous non-solvent for the tetra(dihydrocarbylamino)phosphonium halide is mixed with the separated liquid phase to precipitate the tetra(dihydrocarbylamino)phosphonium halide, which is then separated from the liquid phase. The so-treated tetra(dihydrocarbylamino)phosphonium halide is more efficient as a catalyst for halogen exchange reactions than the original untreated tetra(dihydrocarbylamino)phosphonium halide.Type: GrantFiled: July 13, 1999Date of Patent: April 4, 2000Assignee: Albemarle CorporationInventors: Bruce C. Berris, Chi-Hung Cheng
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Patent number: 6034240Abstract: Novel aminomethylphosphine ligands have particular substituents on the central carbon atom. Such ligands form coordination complexes that may be catalysts for the polymerization of monomers or other catalytic induced reactions.Type: GrantFiled: March 9, 1998Date of Patent: March 7, 2000Assignee: Symyx Technologies, Inc.Inventor: Anne Marie La Pointe
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Patent number: 6020343Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.Type: GrantFiled: June 15, 1998Date of Patent: February 1, 2000Assignee: Merck Frosst Canada, Inc.Inventors: Michel Belley, Jacques Yves Gauthier, Erich Grimm, Yves LeBlanc, Chun-Sing Li, Michel Therien, Cameron Black, Petpiboon Prasit, Cheuk-Kun Lau, Patrick Roy
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Patent number: 6017849Abstract: The present invention generally relates to the regulation of plant physiology, in particular to methods for inhibiting the ethylene response in plants or plant products, and has three embodiments. The first embodiment relates to methods of minimizing impurities capable of reversibly binding to plant ethylene receptor sites during the synthesis of cyclopropene and its derivatives such as methylcyclopropene, thereby avoiding the negative effects these impurities have on plants treated with cyclopropene and its derivatives. The second embodiment relates to complexes formed from molecular encapsulation agents such as cyclodextrin, and cyclopropene and its derivatives such as methylcyclopropene, in addition to cyclopentadiene and diazocyclopentadiene and their derivatives, thereby providing a convenient means for storing and transporting these compounds capable of inhibiting the ethylene response in plants, which are reactive gases and highly unstable because of oxidation and other potential reactions.Type: GrantFiled: August 20, 1998Date of Patent: January 25, 2000Assignee: Biotechnologies for Horticulture, Inc.Inventors: James Daly, Bob Kourelis
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Patent number: 5990352Abstract: A salt useful as an active species in an organic reaction and represented by the following chemical formula (1): ##STR1## wherein n stands for an integer of from 1 to 8, Z.sup.n- represents an n-valent anion of an active hydrogen compound, a, b, c and d each stands for a positive integer, and Rs represent the same or different hydrocarbon groups. In addition, a simple and efficient process is provided for producing a poly(alkylene oxide) by polymerizing an alkylene oxide compound in the presence of the salt represented by the chemical formula (1).Type: GrantFiled: February 5, 1997Date of Patent: November 23, 1999Assignee: Mitsui Chemicals, Inc.Inventors: Tadahito Nobori, Masahiro Kouno, Toshiaki Suzuki, Kazumi Mizutani, Shinji Kiyono, Yoshiho Sonobe, Usaji Takaki
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Patent number: 5952527Abstract: This invention relates to (R)- and (S)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diamine (R-1 and S-1) and (R)- and (S)-2,2'-bis(diarylphospinoamino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binap hthyl (R-2 and S-2) and (R)- and (S)-2,2'-bis(diaklphospinoamino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaph thyl (R-3 and S-3); to a process for the preparation of R-1 and S-1 in which (R) or (S)-1,1'-binaphthyl-2,2'-diamine is partially hydrogenated in the presence of Adam's catalyst (5-20 wt/o of starting material) at 20-100.degree. C.Type: GrantFiled: February 1, 1999Date of Patent: September 14, 1999Assignee: The Hong Kong Polytechnic UniversityInventors: Albert Sun-Chi Chan, Fu-Yao Zhang
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Patent number: 5919968Abstract: A process for preparing an organic pentavalent phosphorus compound comprising oxidizing an organic trivalent phosphorus compound with an aqueous hydrogen peroxide solution in the presence of an inorganic or organic base at a temperature of 0.degree. C. to 50.degree. C. to obtain the corresponding organic pentavalent phosphorus compound.Type: GrantFiled: November 10, 1997Date of Patent: July 6, 1999Assignee: Daihachi Chemical Industry Co., Ltd.Inventors: Kozo Kitamura, Tsuyoshi Kihara, Yoshinori Tanaka, Yoshimi Yano
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Patent number: 5883296Abstract: A mixture is made from (i) a tris(dihydrocarbylamino) phosphoroamidite and/or a hydrohalide thereof, (ii) a strong base (e.g., NaOH) in proportions of about 2.0 to about 4.0 moles of (ii) per mole of (i), and (iii) at least one solvent for the base (e.g., H.sub.2 O). To this mixture is added a hydrocarbyl monohalide (e.g., EtBr) in proportions of about 1.0 to about 3.0 moles per mole of phosphoroamidite used in forming the initial mixture, and the resultant reaction produces tetrakis(dihydrocarbylamino)phosphonium halide. The process enables more efficient production of tetrakis(dihydrocarbylamino)phosphonium halides, and is capable of being effectively used in large scale production facilities while satisfying the economic constraints of commercial operations.Type: GrantFiled: February 14, 1997Date of Patent: March 16, 1999Assignee: Albermale CorporationInventors: John M. Power, Bruce C. Berris, David A. Caillet
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Patent number: 5750755Abstract: A silver halide color photosensitive material is disclosed, which has on a support at least one photosensitive silver halide emulsion layer, wherein at least one nondiffusible compound represented by the following formulas (I), (I-1), or (I-2) is contained to inhibit generation of color stain and color fog and to ensure excellent keeping quality: ##STR1## wherein Y.sup.1 represents atoms completing a phosphorus-containing heterocyclic ring; and ##STR2## wherein R.sup.1 represents an aryl group or a heterocyclic group; R.sup.2 represents an alkyl group, a cycloalkyl group, an aryl group (formula (I-2)), a heterocyclic group (formula CI-2)), an alkoxy group or an aryloxy group; A.sup.1 and A.sup.2 each represent a hydrogen atom or a hydrolyzable group; G represents a carbon atom or a phosphorus atom; X represents an oxygen atom or a sulfur atom; and R.sup.3 represents an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group.Type: GrantFiled: August 12, 1996Date of Patent: May 12, 1998Assignee: Fuji Photo Film Co., Ltd.Inventors: Takashi Nakamura, Hiroshi Fukuzawa, Michio Ono
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Patent number: 5728853Abstract: A process for extracting metal values, especially zinc values, from aqueous solutions of metal salts, which comprises contacting the aqueous solution with an organic phase comprising a compound of the formula, ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, independently, represents an optionally substituted hydrocarbyl or hydrocarbyloxy group or R.sup.1 and R.sup.2 together with the attached phosphorus atom and/or R.sup.3 and R.sup.4 together with the attached phosphorus atom from a 5- to 8-membered heterocyclic ring.Type: GrantFiled: July 11, 1996Date of Patent: March 17, 1998Assignee: Zeneca LimitedInventors: John Campbell, Raymond Frederick Dalton, Peter Michael Quan