Three Or More Carboxamide Groups Patents (Class 564/153)
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Publication number: 20140200257Abstract: The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.Type: ApplicationFiled: January 11, 2012Publication date: July 17, 2014Applicant: ALNYLAM PHARMACEUTICALS, INC.Inventors: Kallanthottathil G Rajeev, Muthiah Manoharan, Muthusamy Jayaraman, Martin Maier, Jayaprakash K. Nair, David Butler
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Patent number: 8778221Abstract: An aromatic amide compound having the following general formula (I) is provided: wherein, X1 and X2 are independently C(O)HN or NHC(O); G1, G2 and G3 are independently hydrogen, C(O)HN-phenyl, or NHC(O)-phenyl, wherein at least one of G1, G2 and G3 is C(O)HN-phenyl or NHC(O)-phenyl; Q1, Q2, and Q3 are independently hydrogen, C(O)HN-phenyl, or NHC(O)-phenyl, wherein at least one of Q1, Q2, and Q3 is C(O)HN-phenyl or NHC(O)-phenyl; R5 is halo, haloalkyl, alkyl, alkenyl, aryl, heteroaryl, cycloalkyl, or heterocyclyl; and m is from 0 to 4.Type: GrantFiled: August 27, 2012Date of Patent: July 15, 2014Assignee: Ticona LLCInventors: Kamlesh P. Nair, Steven D. Gray
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Patent number: 8772296Abstract: Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.Type: GrantFiled: May 31, 2007Date of Patent: July 8, 2014Assignee: Amgen Inc.Inventors: Jay P. Powers, Michael Degraffenreid, Lisa Julian, Jacob Kaizerman, Dustin McMinn, Yosup Rew, Daqing Sun, Xuelei Yan, Zhulun Wang, Felix Gonzalez Lopez De Turiso
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Publication number: 20140187499Abstract: The invention relates to substituted anionic compounds consisting of a backbone made up of a discrete number u of between 1 and 8 (1?u?8) of identical or different saccharide units, linked via identical or different glycosidic bonds, said saccharide units being chosen from the group consisting of pentoses, hexoses, uronic acids, N-acetylhexosamines in cyclic form or in open reduced form, which are randomly substituted. It also relates to the process for the preparation thereof and to the pharmaceutical compositions comprising same.Type: ApplicationFiled: November 13, 2013Publication date: July 3, 2014Inventors: Gérard SOULA, Emmanuel DAUTY, Richard CHARVET
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Patent number: 8766002Abstract: An improved synthesis method for preparation of iodixanol, and a purification process through macroporous adsorption resin chromatographic column and recrystallization are provided. The synthesis method relates to dimerization of 5-acetamido-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (compound A) to prepare iodixanol, wherein excessive side reactions such as alkylation are effectively inhibited by controlling the pH of the reaction mixture with a boron-containing acidic substance or salts thereof such as boric acid. In this way, the conversion rate of compound A to iodixanol is 85-90%. The iodixanol crude product is purified by a macroporous adsorption resin chromatographic column, obtaining iodixanol product with recovery of 90-95% and purity of 96-98%. The iodixanol crude product is recrystallized in mixed solvent containing 2-methoxyethanol, obtaining iodixanol product with recovery of 90-95% and purity of greater than 99%.Type: GrantFiled: November 26, 2009Date of Patent: July 1, 2014Assignee: Imax Diagnostic Imaging Holding LimitedInventors: Zhiqi Hu, Huoying Zhang
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Patent number: 8766003Abstract: The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the corresponding 3,5-disubstituted-2,4,6-triiodophenols, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.Type: GrantFiled: June 9, 2011Date of Patent: July 1, 2014Assignee: Bracco Imaging S.p.A.Inventors: Attilio Citterio, Elisa Battistini, Davide Belnome, Federica Buonsanti, Luciano Lattuada, Gabriella Leonardi, Fulvio Uggeri, Evelin Vignale, Massimo Visigalli
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Publication number: 20140178331Abstract: Methods for preconditioning and/or providing neuroprotection to the animal central nervous system against the effects of cerebral hemorrhage and subarachnoid hemorrhage. Therapeutic agents are administered to the upper third of the nasal cavity to bypass the blood-brain barrier and access the central nervous system directly to avoid unwanted and potentially lethal side effects. Therapeutic agents include those substances that interact with iron and/or copper such as iron chelators, copper chelators, and antioxidants. A particular example of such therapeutic agents is the iron chelator deferoxamine (DFO). An effective amount of DFO may be administered to the upper third of the nasal cavity of a patient at risk for, or diagnosed with, cerebral hemorrhage and subarachnoid hemorrhage. The effective amount of DFO is delivered directly to the patient's central nervous system for preconditioning, preventing and/or treating the cerebral hemorrhage and subarachnoid hemorrhage.Type: ApplicationFiled: October 25, 2013Publication date: June 26, 2014Applicant: HealthPartners Research FoundationInventors: William H. Frey II, Samuel Scott Panter, Leah Ranae Bresin Hanson
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Publication number: 20140179877Abstract: The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules.Type: ApplicationFiled: July 18, 2013Publication date: June 26, 2014Inventors: Rune NILSSON, Bengt SANDBERG, Scott WILBUR
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Patent number: 8754124Abstract: The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided.Type: GrantFiled: November 21, 2012Date of Patent: June 17, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Jung-Mo Ahn, Ganesh Raj
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Publication number: 20140158621Abstract: The present invention relates to a thermo-responsive draw solute that can be applied to water desalination and purification based on forward osmosis. The thermo-responsive draw solute has a molar mass of 50 to 3000 g/mol and undergoes a phase transition at a temperature of 0° C. to 70° C. The thermo-responsive draw solute creates optimum conditions for the desalination of seawater and the purification of contaminated water based on forward osmosis. The present invention also relates to a method for water desalination and purification using the thermo-responsive draw solute. The method consumes little energy for water desalination or purification, is simple to apply to water desalination or purification, and enables separation of the draw solute in a very easy manner.Type: ApplicationFiled: July 27, 2012Publication date: June 12, 2014Applicant: SNU R&DB FOUNDATIONInventors: Yan Lee, Minwoo Noh, Yeongbong Mok, Heejin Kim, Seonju Lee, Daichi Nakayama
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Publication number: 20140135491Abstract: The present disclosure relates to an extraction reactor with which granular material, in particular granular polyamide, can undergo extraction, soluble components being dissolved out of the granular material with an extraction liquid during the extraction. In the case of polyamide materials, these are for example oligomeric or monomeric components which have remained in the granular material during the polycondensation reaction for the production of the polyamide materials.Type: ApplicationFiled: November 6, 2013Publication date: May 15, 2014Applicant: Uhde Inventa-Fischer GmbHInventors: Ekkehard Siebecke, Johannes Katzer, Bernd Königsmann, Mirko Bär
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Publication number: 20140100390Abstract: Disclosed is a polyether compound which is useful as a curing agent or the like, a curing agent using the compound and a producing method of the compound. The polyether compound of the present invention is represented by the following general formula (1). (In the formula, R1 represents a hydrogen atom or a methyl group and R2 represents a hydrogen atom or —C(?O)—C(R3)?CH2. R3 represents a hydrogen atom or a methyl group. R1, R2 and R3 may be the same as or different from each other.Type: ApplicationFiled: September 30, 2013Publication date: April 10, 2014Applicant: FUJIFILM CORPORATIONInventors: Akihito AMAO, Hirotaka KITAGAWA
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Patent number: 8691845Abstract: The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.Type: GrantFiled: July 30, 2012Date of Patent: April 8, 2014Assignee: Erimos Pharmaceuticals LLCInventors: Jonathan Daniel Heller, Qingqi Chen, Rocio Alejandra Lopez, Amanda Jean Morris
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Patent number: 8686045Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.Type: GrantFiled: June 8, 2006Date of Patent: April 1, 2014Assignees: The University of North Carolina at Chapel Hill, The Regents of the University of California, The United States of America as represented by the Department of Veterans AffairsInventors: Frank M. Longo, Stephen M. Massa
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Patent number: 8680334Abstract: A process for the preparation of iosimenol comprising reacting 5,5?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.Type: GrantFiled: February 21, 2013Date of Patent: March 25, 2014Assignee: Mallinckrodt LLCInventors: Allan R. Bailey, Michelle M. Jones, Mills T. Kneller, Alexander N. Petrov, David H. White, Oliver Egan, Fiona Rooney
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Patent number: 8674134Abstract: Disclosed herein is a sequential functionalization methodology for the covalent modification of nanotubes with between one and four repeat units of a polymer. Covalent attachment of oligomer units to the surface of nanotubes results in oligomer units forming an organic sheath around the nanotubes, polymer-functionalized-nanotubes (P-NTs). P-NTs possess chemical functionality identical to that of the functionalizing polymer, and thus provide nanoscale scaffolds which may be readily dispersed within a monomer solution and participate in the polymerization reaction to form a polymer-nanotube/polymer composite. Formation of polymer in the presence of P-NTs leads to a uniform dispersion of nanotubes within the polymer matrix, in contrast to aggregated masses of nanotubes in the case of pristine-NTs.Type: GrantFiled: June 16, 2011Date of Patent: March 18, 2014Assignee: The Regents of the University of CaliforniaInventors: Alexander K. Zettl, Toby Sainsbury, Jean M. J. Fréchet
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Publication number: 20140056835Abstract: The present invention relates to a cosmetic composition for skin whitening comprising a small molecule-peptide conjugate. More specifically, it concerns the cosmetic composition for skin whitening comprising Caffeic acid-LG-NH2 or Coumaric acid-LG-NH2 as an active ingredient, which inhibits tyrosinase activity and melanin production, thereby showing an excellent skin whitening effect, and having no side effects to the skin by using a peptide component.Type: ApplicationFiled: August 22, 2013Publication date: February 27, 2014Applicant: AE KYUNG INDUSTRIAL CO., LTD.Inventors: In Shik CHO, Hyung Seo GOO, Gyeong Yup CHI, Han Young KIM, Hye Suk LEE
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Publication number: 20140051762Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: ApplicationFiled: August 12, 2013Publication date: February 20, 2014Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20140031368Abstract: This disclosure is related to compounds having the structure wherein Ar1, Ar2, R1-R6, Z, m, n, o, and p are defined herein. This disclosure also relates to pharmaceutical compositions comprising the above compounds and methods for their use.Type: ApplicationFiled: July 8, 2013Publication date: January 30, 2014Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCHInventors: Ronald Breslow, Paul A. Marks, K. G. Abhilash, Jianing Wang
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Patent number: 8633228Abstract: A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group derived from a 5- or 6-membered aromatic ring, in combination with A and two carbon atoms to which A bonds, X represents a hydrogen atom, a halogen atom, or the like, n represents an integer of from 0 to 4, T represents —C(?G1)-Q1 (wherein G1 and G2 represent an oxygen atom or the like, Q1 represents a phenyl group which may have a substituent, a heterocyclic group which may have a substituent, or the like), or the like, Q2 represents a phenyl group or the like, G3 represents an oxygen atom or the like, and R1 and R2 each independently represent a hydrogen atom, a C1-C6 alkyl group, or a group represented by -L-D, or the like (provided that at least either R1 or R2 represents a group represented by -L-D); as an active ingredient exhibits an excellent effect.Type: GrantFiled: June 29, 2009Date of Patent: January 21, 2014Assignee: Mitsui Chemicals Agro, Inc.Inventors: Yumi Kobayashi, Hiroyuki Katsuta, Michikazu Nomura, Hidetaka Tsukada, Atsushi Hirabayashi, Hidenori Daido, Yusuke Takahashi, Shinichi Banba
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Publication number: 20140018577Abstract: The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.Type: ApplicationFiled: November 9, 2011Publication date: January 16, 2014Applicant: UCB PHARMA GMBHInventors: Alain Merschaert, Christophe Joseph Szczepaniak, Joerg Hamann, Ralf Kanzler
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Publication number: 20140004592Abstract: One aspect of the invention is a salt comprising guanidinium groups, as shown in formula I. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula II. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula III. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula IV. Yet another aspect of the invention is a salt comprising guanidinium groups, as shown in formula I, II, III, and IV further comprising independently for each occurrence citrate, phosphate, or sulfate anion. Also disclosed are compositions comprising a protein and a salt comprising guanidinium groups, as shown in formula I, II, III, and IV. Also provided are methods of increasing shelf life of an aqueous solution of a protein and decreasing the amount of protein aggregation in an aqueous solution of a protein.Type: ApplicationFiled: November 11, 2011Publication date: January 2, 2014Applicant: Massachusetts Institute of TechnologyInventors: Bernhardt L. Trout, II, Diwakar Shukla, Curtiss P. Schneider
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Patent number: 8617678Abstract: Providing a crosslinkable composition and a crosslinking agent is objected to, which are capable forming a crosslinked product that is superior in retort resistance, with suppressed bleeding out from the crosslinked product, and that has favorable interlayer adhesiveness when formed into a multilayered structure crosslinked product. The present invention provides a crosslinkable composition containing (A) a polymer having an SP value of no less than 9.5 (cal/cm3)1/2 and no greater than 16.5 (cal/cm3)1/2, and (B) a crosslinking agent having one or more polar groups that include an oxygen atom and a nitrogen atom not constituting an aromatic ring, and two or more polymerizable groups. The difference between the SP value of the polymer (A) and the SP value of the crosslinking agent (B) is preferably no greater than 2 (cal/cm3)1/2, and more preferably no greater than 1 (cal/cm3)1/2. A decomposition temperature of the crosslinking agent (B) is preferably no less than 240° C.Type: GrantFiled: March 10, 2011Date of Patent: December 31, 2013Assignee: Kuraray Co., Ltd.Inventors: Kaoru Ikeda, Kazuhiro Kurosaki
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Patent number: 8614346Abstract: The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention provides methods of preparing an amphetamine conjugate from a chloramphetamine intermediate.Type: GrantFiled: June 18, 2010Date of Patent: December 24, 2013Assignee: Cambrex Charles City, Inc.Inventors: Paul Alan Jass, Todd Jeffrey Johnson, Jason Scott Douglas, Matthew Wendell Schiesher
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Publication number: 20130338313Abstract: The invention is based on the discovery that a remarkable improvement in the performance of maleimide thermosets can be achieved by incorporating amide-extended maleimides into an adhesive formulation. Amide-extended maleimides described herein can be used to toughen bismaleimide thermosetting materials without sacrificing any thermal stability. Amide-extended maleimides are readily prepared by reacting a bismaleimide with an appropriate amine via the well-known Michael addition reaction. Acylation of the resulting secondary amines provides the amide-extended maleimide. The acylating agent can also be used to introduce polymerizable functional groups into the backbones of these thermoset monomers. Amide-extended acrylate and methacrylate monomers can also be prepared.Type: ApplicationFiled: August 19, 2013Publication date: December 19, 2013Applicant: Designer Molecules, Inc.Inventors: Stephen M. Dershem, Farhad G. Mizori
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Publication number: 20130324706Abstract: The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is connected to the phenyl ring via the p-amino group, the drug is connected to the phenyl ring via the benzylic alcohol moiety, and the protein is connected to the phenyl ring via the o-hydroxy group; further to a process for the preparation of said protein-drug-conjugates via various intermediates, to the pharmaceutical use of such protein drug conjugates, such as methods of controlling the growth of undesirable cells, to pharmaceutical compositions comprising such protein drug conjugates, and to intermediates of the preparation of the protein drug conjugates.Type: ApplicationFiled: February 23, 2012Publication date: December 5, 2013Inventors: Laurent Ducry, Bernhard Stump, Heilam Wong, Jin She, Gayle Phillips
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Publication number: 20130324688Abstract: The preparation of cyclohexadienes from one or more plant oils is disclosed. The cyclohexadiene can be used to form polymers or derivatized to form other monomers that can be used to form polymeric materials.Type: ApplicationFiled: April 9, 2013Publication date: December 5, 2013Inventor: Robert T. MATHERS
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Publication number: 20130309733Abstract: One aspect of the present disclosure relates to a stabilized recombinant expression plasmid vector comprising a polynucleotide encoding an antitoxin gene which expresses a polypeptide that neutralizes a polypeptide toxic to a host cell, the toxic polypeptide being expressed by a toxin gene in the host cell, and a polynucleotide encoding a polypeptide expression product, and the stabilized recombinant expression plasmid vector is derived from a Hafnia alvei autonomously replicable backbone plasmid. Other aspects of the present disclosure relate to a transformant transformed with the stabilized recombinant expression plasmid vector disclosed herein, a method of producing biobased cadaverine using the transformant disclosed herein, and biobased cadaverine prepared by the method disclosed herein. Another aspect of the present disclosure relates to a polyamide formed using biobased cadaverine disclosed herein, and a composition thereof.Type: ApplicationFiled: March 12, 2013Publication date: November 21, 2013Applicants: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Zhenhua PANG, Naiqiang LI, Charlie LIU
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Publication number: 20130296606Abstract: A compound represented by formula (I): wherein, in formula (I), R represents a hydrogen atom or an alkyl group having 1 to 4 carbon atom(s); Ra represents a hydrogen atom, an alkyl group, an aryl group, or a heterocyclic group; X represents a halogen atom, or an alkyl- or aryl-sulfonyloxy group; L represents a divalent linking group; Z represents a (n+1)-valent organic group; and n represents an integer of 1 to 6, a plurality of Rs and Ras and Xs may be the same or different from each other, respectively, and when n represents 2 to 6, a plurality of Ls may be the same or different from each other.Type: ApplicationFiled: February 22, 2013Publication date: November 7, 2013Applicant: FUJIFILM CORPORATIONInventor: FUJIFILM CORPORATION
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Patent number: 8575390Abstract: In accordance with the disclosure, one aspect of the present application is directed to a dispersant compound comprising the reaction product of (i) a hydrocarbyl carbonyl compound, (ii) a polycarbonyl compound having at least three carbonyl acylating functions, and (iii) a primary amine moiety of a polyamine. Methods of making and methods of using the dispersant compound are also disclosed.Type: GrantFiled: December 21, 2010Date of Patent: November 5, 2013Assignee: Afton Chemical CorporationInventor: John T. Loper
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Patent number: 8563714Abstract: The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds as ALX receptor and/or FPRL2 agonists for the treatment of inflammatory and obstructive airways diseases.Type: GrantFiled: May 17, 2010Date of Patent: October 22, 2013Assignee: Actelion Pharmaceuticals Ltd.Inventors: Daniel Bur, Olivier Corminboeuf, Sylvaine Cren, Corinna Grisostomi, Xavier Leroy, Sylvia Richard-Bildstein
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Publication number: 20130272965Abstract: Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.Type: ApplicationFiled: December 28, 2011Publication date: October 17, 2013Applicant: HANWHA CHEMICAL CORPORATIONInventors: Taeghwan Hyeon, Kun Na, Daishun Ling, Wooram Park
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Publication number: 20130274502Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 19, 2012Publication date: October 17, 2013Applicant: PolyMedix, Inc.Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
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Publication number: 20130251809Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.Type: ApplicationFiled: March 8, 2013Publication date: September 26, 2013Applicant: Egen, Inc.Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
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Patent number: 8541620Abstract: The present invention relates to a method for selectively crystallizing Z isomer of iopromide of formula (I) comprising a) dissolving a crude iopromide comprising a mixture of E and Z isomers or a concentrate thereof in an alcohol, and b) heating the resulting alcohol solution to obtain crystalline of Z isomer of iopromide; and a method for preparing a composition comprising the crystalline Z isomer of iopromide.Type: GrantFiled: October 21, 2009Date of Patent: September 24, 2013Assignee: Daewoong Pharmaceutical Co., Ltd.Inventors: Soo-Jin Choi, Byung-Goo Lee, Han-Kuk Lee, Young-Mook Lim, Wol-Young Kim, Joon-Hwan Lee
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Publication number: 20130244944Abstract: Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.Type: ApplicationFiled: December 31, 2012Publication date: September 19, 2013Applicants: VERSITECH LIMITED, THE UNIVERSITY OF HONG KONGInventors: Dan Yang, Xiang Li, Huiyan Zha
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Publication number: 20130245270Abstract: The present invention describes tripodal catechol derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. The remaining fourth bridgehead position is easily suitable to be further functionalised via so-called click reactions, e.g. with biomolecules, dyes, radiomarkers, polyethylene glycol or active agents.Type: ApplicationFiled: September 7, 2011Publication date: September 19, 2013Applicant: JUSTUS-LIEBIG-UNIVERSITAT GIESSENInventors: Wolfgang Maison, Faiza Khalil, Elisa Franzmann
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Patent number: 8519189Abstract: Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.Type: GrantFiled: September 27, 2011Date of Patent: August 27, 2013Assignee: University of British ColumbiaInventors: Jayachandran N. Kizhakkedathu, Rajesh A. Shenoi, Cedric J. Carter, Donald E. Brooks
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Patent number: 8518885Abstract: A novel class of peptide ?-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA2-AA1-CO—NH—(CH2)n—R3. Processes for the synthesis of peptidyl ?-ketoamide derivatives. Compositions and methods for inhibiting cysteine proteases, inhibiting calpains, and treating disease caused by cysteine proteases and calpains are provided.Type: GrantFiled: July 16, 2008Date of Patent: August 27, 2013Assignees: Georgia Tech Research Corporation, Emory UniversityInventors: James C. Powers, Jonathan D. Glass, Asli Ovat, Zhaozhao Li
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Patent number: 8519188Abstract: The present invention relates to a compound of general formula (I): and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in particular to an enantiomer mixture, and especially to a racemic mixture. The present invention also relates to the use of these compounds as a medicament, and in particular for the treatment of cancer, and also to the compositions containing them.Type: GrantFiled: June 15, 2009Date of Patent: August 27, 2013Assignee: Marc-Henry PittyInventors: Denis Carniato, Karine Jaillardon, Olivier Busnel, Mathieu Gutmann, Jean-Francois Briand, Benoit Deprez, Dominique Thomas, Cécile Bougeret
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Publication number: 20130210887Abstract: The present invention relates to novel compounds of general formula (I) and (II) for their use in gene therapy as non-viral vehicles and their use for the preparation of a medicament. It also discloses the process of synthesis of said compounds of general formula (I) and (II).Type: ApplicationFiled: March 4, 2011Publication date: August 15, 2013Applicant: UNIVERSIDAD DE CASTILLA LA MANCHAInventors: Valentin Cena Callejo, Maria Del Prado Sánchez Verdu, Sonia Merino Guijarro, Joaquin Calixto García Martínez, Julián Rodríguez López, Ester Vázquez Fernández-Pacheco, María Antonia Herrero Chamorro, Ana Campo Rodrigo, Iván Rivilla De La Cruz, Francisco Carlos Pérez Martínez, Francisco Javier Guerra Navarro
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Patent number: 8507723Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: June 21, 2012Date of Patent: August 13, 2013Assignee: Polymedix, Inc.Inventors: Shaker Mousa, Dahui Liu
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Patent number: 8507612Abstract: A crosslinkable, pre-adhesive composition is described comprising an acid-functional (meth)acrylate copolymer and an aziridine crosslinking agent, which when crosslinked provides a pressure-sensitive adhesive and pressure-sensitive adhesive articles.Type: GrantFiled: February 22, 2010Date of Patent: August 13, 2013Assignee: 3M Innovative Properties CompanyInventors: Peiwang Zhu, Zhong Chen, Babu N. Gaddam, Larry R. Krepski, Jingjing Ma, David B. Olson, Andrew Satrijo, Dong-Wei Zhu
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Patent number: 8501813Abstract: It is intended to provide a novel compound that has an excellent ?-secretase inhibitory effect and specifically inhibits A? production. The present invention provides a compound of the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a linear or branched alkyl group having 1 to 4 carbon atoms or a phenyl group; R2 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more phenyl or halogenophenyl groups; R3 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more hydroxyl groups; R4 represents a linear or branched alkyl group having 1 to 4 carbon atoms; and the symbol “*” represents a chiral center.Type: GrantFiled: July 1, 2008Date of Patent: August 6, 2013Assignee: Kabushiki Kaisha Yakult HonshaInventors: Atsuhiro Abe, Hideaki Shimizu, Seigo Sawada, Hiroshi Kodaira
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Publication number: 20130180919Abstract: A draw solute for forward osmosis may include a temperature-sensitive oligomer compound including a structural unit including a temperature-sensitive moiety. The temperature-sensitive oligomer compound may further include a hydrophilic functional group at the terminal end of the main chain.Type: ApplicationFiled: June 5, 2012Publication date: July 18, 2013Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jae Eun Kim, Bo Kyung Jung, Sung Soo Han
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Publication number: 20130172232Abstract: Compounds of the formula I wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R3 is a C5-C10 alkyl, optionally substituted with 1-3 substituents independently selected from halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy; or R3 is a C2-C4alkyl chain with at least 2 chloro or 3 fluoro substituents; or R3 is C3-C7cycloalkylmethyl, optionally substituted with 1-3 substituents independently selected from C1-C4alkyl, halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy; R4 is C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylamino, C1-C6dialkylamino or; R4 is Het or Carbocyclyl, either of which is optionally substituted with 1-3 substituents R4 is Het, carbocyclyl, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy or C1-C6haloalkoxy; n is 1, 2 or 3; for the use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathType: ApplicationFiled: June 16, 2011Publication date: July 4, 2013Applicant: MEDIVIR UK LTDInventors: Susana Ayesa, Urszula Grabowska, Ellen Hewitt, Daniel Jonsson, Bjorn Klasson, Pia Kahnberg, Stina Lundgren, Jan Tejbrant, Daniel Wiktelius
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Publication number: 20130150442Abstract: The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided.Type: ApplicationFiled: November 21, 2012Publication date: June 13, 2013Applicant: The Board of Regents of the University of Texas SystemInventor: The Board of Regents of the University of Texas S
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Publication number: 20130140495Abstract: This disclosure includes a process that unexpectedly can produce very inexpensive graphene, functionalized graphenes, and a new compound called graphenol in particulate or dispersions in solvents. The process can also produce graphene layers on metallic and nonmetallic substrates. Further, the graphenol, functionalized graphenes, and graphene can be utilized to form nanocomposites that yield property improvements exceeding anything reported previously.Type: ApplicationFiled: June 1, 2012Publication date: June 6, 2013Applicant: NATIONAL NANOMATERIALS, INC.Inventor: Gary W. Beall
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Publication number: 20130131311Abstract: Improved methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) under mild conditions without the use of protecting groups, and without requiring that a cysteine residue be present in the ligation product. Initial coupling of the thioacid and the aziridinyl compound yields a ligation product which contains an aziridinyl ring. Subsequent opening of the aziridinyl ring (e.g. via a nucleophilic attack) produces a linearized and modified ligation product.Type: ApplicationFiled: November 13, 2012Publication date: May 23, 2013Applicant: WASHINGTON STATE UNIVERSITYInventor: Washington State University
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Publication number: 20130131381Abstract: A process for the manufacture of polyamide is described. Also described, is a process comprising a stage of initial polymerization under pressure starting from monomers and a stage of finishing in the liquid phase at atmospheric pressure. The finishing stage can employ an injection of inert gas along a direction essentially parallel to that of the flow of the liquid reaction stream.Type: ApplicationFiled: July 12, 2011Publication date: May 23, 2013Applicant: RHODIA OPERATIONSInventor: Sébastien Lomel