Plural Alicyclic Rings In Substituent Q Patents (Class 564/188)
  • Patent number: 4324912
    Abstract: Described are compounds having the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond and wherein R.sub.2 is methyl or hydrogen; R.sub.6 is methyl or hydrogen; R.sub.1, R.sub.3 or R.sub.7 represent methyl or hydrogen, with the proviso that one of R.sub.1, R.sub.3 and R.sub.7 represents methyl and the other two of R.sub.1, R.sub.3 and R.sub.7 represent hydrogen; wherein R.sub.4 and R.sub.5 are the same or different and each represents hydrogen or C.sub.1 -C.sub.3 lower alkyl.
    Type: Grant
    Filed: November 13, 1980
    Date of Patent: April 13, 1982
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Philip T. Klemarczyk, Frederick L. Schmitt, Edward J. Granda, Domenick Luccarelli, Jr.
  • Patent number: 4313005
    Abstract: This invention relates to a process for reducing amidine formation during reduction of organonitriles. The process comprises including a boron compound in the reaction medium in sufficient amount to complex the amidine compound as it is formed.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: January 26, 1982
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Michael E. Ford, Randall J. Daughenbaugh
  • Patent number: 4308396
    Abstract: Stable biologically active thromboxane A.sub.2 analogues having the formula ##STR1## wherein R.sup.1 is OR.sup.3, where R.sup.3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group; orR.sup.1 is NR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 are the same or different substituents selected from the group consisting of hydrogen and lower alkyl group; andR.sup.2 is hydrogen or an --OH group.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: December 29, 1981
    Assignee: Research Corporation
    Inventors: Kyriacos C. Nicolaou, Ronald L. Magolda
  • Patent number: 4288609
    Abstract: Compounds having the general formula: ##STR1## in which: Ad is 1-adamantyl (C.sub.10 H.sub.15) radicalA is oxygen atom or --NH--(imino) groupR is --CH.sub.3 (methyl) group or --C.sub.2 H.sub.5 (ethyl) groupR' is a linear aliphatic chain containing from 10 to 12 atoms of carbonX.sup.- is a halide ion.The halide may be chlorine or bromine. The compounds exhibit an antibacterial, antimould and antiprotozoic activity and may be formulated as pharmaceutical and cosmetic preparations or used as preservatives for food products.
    Type: Grant
    Filed: December 4, 1979
    Date of Patent: September 8, 1981
    Assignee: Rotta Research Laboratorium S.p.A.
    Inventors: Luigi Rovati, Francesco Makovec, Paolo Senin
  • Patent number: 4277473
    Abstract: Compounds having the formula ##STR1## wherein a is 0 or 1, R.sub.1 is hydrogen or lower alkyl, A is lower alkylene or lower alkylidene, and R.sub.2 and R.sub.3, which can be the same or different, are hydrogen, lower alkyl, cycloalkyl, benzyl or substituted benzyl, or ##STR2## is a saturated heterocyclic ring, and acid addition salts thereof, possess anti-viral activity and reduced activity on the central nervous system.
    Type: Grant
    Filed: December 12, 1979
    Date of Patent: July 7, 1981
    Assignees: Kao Soap Co., Ltd., Sumitomo Chemical Industries Ltd.
    Inventors: Yoshiaki Inamoto, Motoyoshi Osugi, Eiji Kashihara
  • Patent number: 4271050
    Abstract: Vulcanizable rubber compositions are described which are inhibited from premature vulcanization by activated methylene di(thioethers) in which the adjacent activating groups are either carbonyl or cyano. Novel compounds are also described.
    Type: Grant
    Filed: November 23, 1979
    Date of Patent: June 2, 1981
    Assignee: Monsanto Company
    Inventors: Otto W. Maender, Eiichi Morita
  • Patent number: 4267111
    Abstract: This invention concerns processes for preparing .beta.-santalol, .beta.-santalene, dihydro-.beta.-santalol, tetrahydro-.beta.-santalol and related compounds from camphene. The invention further concerns novel compounds useful as intermediates in these processes and as fragrance adjuncts.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: May 12, 1981
    Assignee: Fritzsche Dodge & Olcott Inc.
    Inventors: Brian J. Willis, Philip A. Christenson, Derek H. R. Barton
  • Patent number: 4267371
    Abstract: The present invention provides novel 19-hydroxy-6a-carba-PGI.sub.1 amides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: May 12, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Patent number: 4260806
    Abstract: Stable biologically active thromboxane A.sub.2 analogues having the formula: ##STR1## wherein R.sup.1 is OR.sup.3, where R.sup.3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group; orR.sup.1 is NR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 are the same or different substituents selected from the group consisting of hydrogen and lower alkyl group; andR.sup.2 is hydrogen or an --OH group.The thromboxane analogues are potent thrombotic agents, useful in cardiovascular treatment.
    Type: Grant
    Filed: October 24, 1979
    Date of Patent: April 7, 1981
    Assignee: Research Corporation
    Inventors: Kyriacos C. Nicolaou, Ronald L. Magolda, David A. Claremon
  • Patent number: 4256663
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-6a-carba-PGI.sub.1 amides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: March 17, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Patent number: 4252804
    Abstract: Compounds of the formula I ##STR1## wherein m and n are 0, 1 or 2, X represents oxygen, imino, benzylimino, or morpholinoethylimino, Y represents CO, CONH, COO or SO.sub.2, and NR.sub.1 R.sub.2 represents a dimethylamino, diethylamino, dipropylamino, dibutylamino, allylamino, isobutenylamino, cyclopentylamino, cyclohexylamino, cycloheptylamino, cyclooctylamino, N-methyl N-cyclopentylamino, N-methyl N-cyclohexylamino, N-allyl N-cyclohexylamino, adamantylamino, diethoxyethylamino, dimethylaminoethylamino, dimethylaminopropylamino, N-methyl N-dimethylaminopropyl-amino, benzylamino, 3,4,5-trimethoxybenzylamino, phenethylamino, p-chlorophenethylamino, tetrahydrofurfurylamino, tetrahydropyranylmethylamino, pyrrolidino, isoxazolidinyl, piperidino, 4-hydroxypiperidino, 4-m-chlorophenyl-4-hydroxypiperidino, homopiperidino, 1,2,3,6-tetrahydropyridyl, morpholino, 2-methylmorpholino, 2,6-dimethylmorpholino, 2-morpholinoethylamino, thiamorpholino, piperazino, 4-methylpiperazino, 4-(.alpha.
    Type: Grant
    Filed: January 13, 1978
    Date of Patent: February 24, 1981
    Assignee: Metabio-Joullie
    Inventors: Maurice Joullie, Gabriel Maillard, Lucien Lakah, Christian J. M. Warolin
  • Patent number: 4248893
    Abstract: Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(.alpha.-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed anhydride of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate amino compound.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: February 3, 1981
    Assignee: Sandoz, Inc.
    Inventors: Faizulla G. Kathawala, John G. Heider