Thiocarbazides Or Thiosemicarbazides (i.e. Hnh-nh-c(=s)-hnh, Wherein The N Bonded Directly To The Thiourea N Is An Amino N And Substitution May Be Made For Hydrogen Only) Patents (Class 564/18)
Abstract: A direct positive silver halide photographic light-sensitive material is described, comprising a support having coated thereon a light-sensitive silver halide photographic emulsion layer and a hydrophilic colloid layer, at least one of said layers containing a compound represented by the formula (I): ##STR1## wherein R.sup.1 represents R.sup.6 or R.sup.6 CO--; and R.sup.6 represents an aliphatic group, an aromatic group, a heterocyclic aromatic group or hydrogen; R.sup.2 and R.sup.4, which may be the same or different, each represents an aliphatic group, an aromatic group, a heterocyclic aromatic group or a hydrogen atom; or R.sup.1 and R.sup.2 together can form a ring; R.sup.3 represents hydrogen or an aliphatic group; R.sup.5 represents Y or X--A--Y wherein X and Y, which may be the same or different, each represents a divalent aromatic group; and A represents a divalent group selected from --CONH--, --NHCONH--, --SO.sub.2 NH--, --B--CONH-- and --B--SO.sub.
Abstract: Compounds of the formula (I): ##STR1## wherein n is 3 to 5;Y is --CH.sub.2 --CH.sub.2, --CH.dbd.CH-- or C.tbd.C--;L is O or S;R.sub.1 is C.sub.1-4 alkyl;R.sub.2 is hydrogen, C.sub.1-4 alkyl or phenyl;R.sub.3 is hydroxy or protected hydroxy;R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl, phenyl, naphthyl, any of which phenyl moieties or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or nitro groups; orR.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and R.sub.5 is C.sub.1-6 alkyl, having similar activity to natural prostaglandins, a process for their preparation, intermediates useful in that process and pharmaceutical compositions containing them.
Abstract: The present invention is directed to a class of novel 1-benzoyl-3-thiosemicarbazides which are useful as plant growth regulants. The present invention is also directed to methods and formulations for plant growth regulation.
Abstract: This disclosure describes anthracene-9,10-bis-carbonyl-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers.
Abstract: In the production of thiosemicarbazide comprising the steps of reacting hydrazine and ammonium thiocyanate to form hydrazinium thiocyanate and by-product ammonia, and heating the hydrazinium thiocyanate to effect isomerization thereof to thiosemicarbazide, the improvement which comprises removing the ammonia from the hydrazinium thiocyanate prior to isomerization thereof, whereby the thiosemicarbazide is produced in high yield and purity. Advantageously at least about 80% of the ammonia is removed by steam stripping and/or vacuum distillation and the subsequent isomerization is effected by prolonged heating in the presence of a carbonyl compound such as acetone or acetaldehyde. The thiosemicarbazide is recovered by cooling to effect crystallization, followed by filtration, the mother liquor being recycled as solvent medium for the next batch.
Type:
Grant
Filed:
November 1, 1979
Date of Patent:
March 17, 1981
Assignee:
Mobay Chemical Corporation
Inventors:
Danny B. Barton, Chester W. Halbleib, Jack J. Lonsinger
Abstract: Disclosed is a process for producing 2-amino or 2-(lower alkyl or phenyl)amino-5-mercapto-1,3,4-thiadiazole compounds by reacting the corresponding thiosemicarbazide with an alkali metal lower alkyl xanthate salt.