Abstract: Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R.sub.3 is hydrogen, acyl, or benzyl; and R.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, phenyl-alkylene, heterocyclic-alkylene, etc. These compounds are useful as cardiovascular agents.

Abstract: .alpha.-fluoro-.beta.-dicarbonyl compounds are prepared by reacting a halogenated dicarbonyl compound at temperatures of 20.degree. to 100.degree. C. with an addition product of hydrogen fluoride and a trialkylamine. This process is easy to carry out in technical terms and can also be carried out on a large scale.

Abstract: The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8.

Abstract: This invention relates to new gem-diamino derivatives of general formula (I) ##STR1## where R is the side chain of an amino acid, of which any functional groups are suitably protected, andX is an acyl group chosen from the group consisting of 2-nitrobenzoyl, 4-chloro-butyryl, acetoacetyl, 4-bromo-butyryl, (2-nitrophenoxy)-acetyl and 2-methyl-2-(2'-nitro-phenoxy)propionyl, of use in introducing gem-diamino residues into retro-inverso peptides. The invention further relates to a method for the synthesis of retro-inverso peptides in which the gem-diamino residue or residues are introduced using the new compound (I).

Abstract: Poly (alkylene oxide) substituted acetoacetanilides of the formula: ##STR1## wherein B comprises a divalent bridging moiety selected from the group consisting of C.sub.1 -C.sub.6 alkylene, --NHSO.sub.2 --, --O--, --CO--, --COO--, and --NCHO--; X comprises a poly (alkylene oxide) having a number average molecular weight of about 200 to 10,000; R comprises 0 to 4 moieties independently selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and halogen; and d is an integer of 1 to 3. The poly (alkylene oxide) substituted acetoacetanilides are prepared by reacting a poly (alkylene oxide) monoamine, diamine or triamine with isatoic anhydride followed by acetoacetylation of the resultant aminobenzamide. The substituted acetoacetanilides are useful for preparing improved diarylide pigment compositions which in turn are useful for preparing storage stable printing inks (especially of the publication gravure type).

Abstract: The present invention provides compounds of the general formula: ##STR1## wherein R.sup.1 is an amino acid residue or a residue of an oligopeptide in which the amino groups are optionally substituted by protective groups, R.sup.2 and R.sup.3, which are the same or different, are hydrogen atoms, a lower alkyl, lower alkoxy, carboxyl or lower alkoxycarbonyl radicals or carboxamido groups optionally substituted by lower alkyl or, if R.sup.2 and R.sup.3 are adjacent, can represent a --CH.dbd.CH--CH.dbd.CH-- radical, Z is a conjugated-through positively charged, bicyclic heterocyclic system and X is an anion of an organic or inorganic acid. The present invention also provides processes for the preparation of these compounds and diagnostic agents containing them for the determination of peptide bond-cleaving enzymes.

Abstract: A novel process for producing 2-chloro-1,3-diketo compounds of the formula ##STR1## wherein Q is an amino, substituted amino or hydrocarbyloxy group, e.g., --OCH.sub.3, wherein the 1,3-diketo precursor in solution in a low boiling alcohol is neulized in a special chlorinator with chlorine or a mixture of nitrogen and chlorine, and wherein the chlorination of the nebulized precursor solution takes place extremely rapidly at relatively high temperatures in a chlorination zone, the product being recovered by condensation on the cooled chlorinator walls and stripping of the alcohol solvent. A representative product is 2-chloro-N,N-dimethylacetoacetamide (2CDMAA), a useful intermediate for the production of insecticides, drugs, dyes and other complex compounds.

Abstract: S-substituted beta-thioacrylamide compounds have been discovered to be useful as biocides and fungicides. Compositions comprising the compound and isothiazolin-3-ones and/or carriers, methods of preparation of the compounds and methods of using the compounds and compositions are also disclosed.

Abstract: This invention is directed to compounds of the formula (I): ##STR1## wherein R.sup.1 is --OR.sup.4 (where R.sup.4 is hydrogen, lower alkyl, lower hydroxyalkyl, phenyl, phenyl-lower-alkyl, or --(CH.sub.2).sub.n Y where n is an integer from 1 to 4 and Y is morpholino, -SR.sup.5, --C(O)OR.sup.5, --C(O)N(R.sup.6).sub.2, --N(R.sup.6).sub.2, or --N.sup.+ (R.sup.6).sub.3 X.sup.-, in which R.sup.5 is lower alkyl, each R.sup.6 is independently selected from hydrogen or lower alkyl, and X is halogen)or --SR.sup.7 (where R.sup.7 is lower alkyl, phenyl-lower-alkyl, or --(CH.sub.2).sub.n W where W is --N(R.sup.6).sub.2 or --N.sup.+ (R.sup.6).sub.3 X.sup.-, and n, R.sup.6 and X are as previously defined);R.sup.2 is lower alkyl, phenyl or phenyl-lower-alkyl;R.sup.3 is halo, hydroxy, lower alkyl, lower alkoxy, lower haloalkyl, lower haloalkoxy, or --C(O)OR.sup.5 where R.sup.5 is as previously defined; andZ is a bond, 2,5-thienyl or 2,5-furanyl; or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed is a diacetylene compound comprising, as structural units, (a) at least one member selected from diacetylene group-containing organic groups of the formulae (I) and (II):R.sup.I --C.tbd.C--C.tbd.C--R.sup.II -- (I)and--R.sup.III --C.tbd.C--C.tbd.C--R.sup.IV -- (II)wherein R.sup.I is hydrogen or a (C1-16) monovalent organic group, and R.sup.II, R.sup.III and R.sup.IV are a (C1-13) divalent organic group, (b) at least one organic group having at least one carbon-to-carbon double bond, and (c) at least one connecting group connecting the units (a) and (b), which connecting group is selected from amide, imide, ester, ether, amino, imino, urethane, sulfonyl and carbonyl bonds. A cured shaped article made of this compound exhibits isotropically a high elastic modulus and has excellent mechanical properties.

Abstract: Compounds of the formula ##STR1## wherein X is a halogen atom, R the same or different substituents in any desired position of the benzene ring, namely, halogen atoms, C.sub.1 -C.sub.3 -alkyl groups, trifluoromethyl groups or cyano groups and n a whole number with a value of 1, 2 or 3, are fungicidally active.

Abstract: Certain 2-quinoxalinol-4-oxides are selectively reduced to form 2-quinoxalinols employing hydrogen as a reducing agent by reacting such 2-quinoxalinol-4-oxides with a catalyst selected from the group consisting of sulfided platinum, sulfided palladium, sulfided rhodium and sulfided ruthenium.

Abstract: Herbicidally active thiolcarbamates are employed in combination with a certain amide extender compound, the latter in sufficient quantity to minimize soil degradation and to prolong the soil life of the former. As a result, the herbicidal effectiveness of the thiolcarbamate herbicide is significantly enhanced and prolonged, rendering a single application or multiple applications of the herbicide effective over a longer period of time. Such herbicidal compositions can optionally contain a non-phytotoxic antidotally effective amount of thiolcarbamate herbicide antidote.

Abstract: A process for efficiently preparing 2-amino-5-nitrophenol derivatives in which benzoxazole derivatives are subjected to nucleophilic substitution reaction at the 5 position thereof to obtain corresponding benzoxazole derivatives, and the oxazole ring of the benzoxazole derivatives is then subjected to ring-opening to obtain 2-amino-5-nitrophenol derivatives. The 2-amino-5-nitrophenol derivatives are useful as industrial starting materials, reducing agents or antioxidants and intermediates for cyan-image-forming couplers.

Abstract: Compounds of the formula ##STR1## where n is 0 or 1,R is alkyl, phenyl or R.sub.4 -substituted phenyl,R.sub.2 and R.sub.3 are, independently, alkyl orR.sub.2 and R.sub.3 together with N is ##STR2## m is 1, 2 or 3, R.sub.1 and R.sub.4 are, independently hydrogen, halo, alkyl or alkoxy, andR.sub.5 is hydrogen or alkyl of 1 to 6 carbon atomsor their pharmaceutically acceptable salts are useful as anti-diabetic agents, in particular, as hypoglycemic agents or inhibitors of post-prandial hypoglycemia.

Abstract: Perfluoropolyether oligomers or block polymers, having a backbone with one or a plurality of perfluoropolyether segments each consisting essentially of (1) at least one perfluoroisopropyleneoxy unit, (2) a bis(perfluoromethyleneoxy-terminated) unit, and (3) a perfluoroethylidene unit terminating each segment, the backbone of the perfluoropolyether being terminated with COF and/or a functional or nonfunctional derivative thereof, said perfluoropolyethers being made by reacting a perfluoroaliphatic diacid fluoride with hexafluoropropylene epoxide to produce an acid fluoride-terminated perfluoropolyether adduct or oligomer which then can be photopolymerized to yield an acid fluoride-terminated perfluoropolyether block polymer. These oligomers and block polymers are useful as high temperature lubricants, hydraulic fluids, gaskets, adhesives and coatings as well as co-reactants wtih urethane in forming propellant binders.

Abstract: Provided are antihypertensive compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the same or different,m is an integer from 0 to 2 inclusive,n is an integer from 0 to 4 inclusive,M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl.Y is hydroxy, alkoxy, amino, or substituted amino, aminoalkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is alkyl, aryl, aralkyl, cycloalkyl, cycloalkyl-alkyl, heterocyclic, --CO--SR, --CS--SR, ##STR2## CH.sub.2 CO.sub.2 R, --CHM--CO.sub.2 R, --CH.sub.2 --CO--SR, --CN, ##STR3## --CO--NH--CH.sub.2 CO.sub.2 R, ##STR4## or --CO--CO.sub.

Abstract: Process for the production of 4-(trialkylammonium)-acetoacetarylides having the formula: ##STR1## wherein R is H, a lower alkyl, --OCH.sub.3, --OC.sub.2 H.sub.5, --Cl, --Br, --NO.sub.2, --NHCOCH.sub.3 or an anilated heterocyclic ring; n is 1 to 3; R.sup.1, R.sup.2 and R.sup.3 each is an alkyl having 1 to 18 C atoms; and X is Cl or Br. Such arylide is prepared by reacting a corresponding trialkylamine with a corresponding 4-haloacetoacetarylide at a low temperature in the presence of an organic solvent.

Abstract: Process for the production of 4-(trialkylammonium)-acetoacetarylides having the formula: ##STR1## wherein: R is H, a lower alkyl, --OCH.sub.3, --OC.sub.2 H.sub.5, --Cl, --Br, --NO.sub.2, --NHCOCH.sub.3 or an anilated heterocyclic ring; n is 1 to 3; R.sup.1, R.sup.2 and R.sup.3 each is an alkyl having 1 to 18 C atoms; and X is Cl or Br. Such arylide is prepared by reacting a corresponding trialkylamine with a corresponding 4-haloacetoacetarylide at a low temperature in the presence of an organic solvent.

Abstract: The reaction product of (i) an aromatic amide having the amine group of the amide attached to an aromatic ring, and (ii) a mono- or di-epoxide, has been found to be a good fortifier of epoxy resins. Epoxy resins have been found to attain increased strength and modulus (yet not brittle) by compounding:(a) a resin-forming polyepoxide,(b) an amine curing agent for (a), and(c) the above fortifier; and heat curing the mixture. Strengths as high as 130-150 MPa and modulus values to as high as 5000 MPa have been achieved yet with a ductile mode of fracture.

Abstract: Acyl anilines are disclosed having the formula ##STR1## wherein R and R.sup.1 (like or unlike each other)=H; CH.sub.3 ; C.sub.2 H.sub.5 ; n.C.sub.3 H.sub.7 ; --CH.sub.2 --CH.dbd.CH.sub.2 ; --CH.dbd.CH--CH.sub.3 ;R.sup.3 and R.sup.4 (like or unlike each other)=H; alkyl C.sub.1 -C.sub.3 ; halomethyl; Cl; F; CN; O-alkyl; S-alkyl; alkoxymethyl; orR.sup.3 and R.sup.4 together are (CH.sub.2 .dbd.) ##STR2## n=0,1 Z=phenyl optionally substituted; ##STR3## And R.sup.2 =H, CH.sub.3 ; m=1,2; Y=alkynyl C.sub.2 -C.sub.8 ; phenyl optionally substituted; phenyl-acetyl; furyl, thienyl; pyridyl; heterocyclic groups containing 2 or 3 heteroatoms, one of them different from nitrogen;R.sup.8 =CH.sub.3 ; alkoxymethyl; halomethyl; O-alkyl.The compounds of formula I are endowed with a high fungicidal activity and with a low phytotoxicity.

Abstract: The invention relates to novel microbicides of the general formula I ##STR1## wherein R is hydrogen or methyl, Ar is a phenyl or .alpha.-naphthyl group which is substituted by NH.sub.2 or NO.sub.2 and further radicals, W is a cyano, ester, alkenyl or alkynyl group, and B is alkyl, alkenyl, cyclopropyl, 2-furyl, 2-tetrahydrofuryl, .beta.-(alkoxy)ethyl, triazolylmethyl, methylsulfonylmethyl, alkoxymethyl, alkenyloxymethyl, alkynyloxymethyl, alkylthiomethyl, alkenylthiomethyl, alkynylthiomethyl, --OSO.sub.2 -alkyl, --OSO.sub.2 NH(alkyl) or --N(alkyl).sub.2. The invention also describes plant protection compositions which contain these compounds, a process for the production of the novel compounds and compositions, and a method of controlling phytopathogenic microorganisms which comprises the use thereof.

Abstract: 3-Nitro-acetoacetanilides of the formula ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 independently of one another represent hydrogen, alkyl, cycloalkyl or aryl, it being possible for two of the said radicals to form a cycloaliphatic ring together with the carbon atom on which they are substituents, andR.sup.4 and R.sup.5 independently of one another denote hydrogen, alkyl, aralkyl, aryl, alkoxy, alkylthio, aralkoxy, aralkylthio, aryloxy, arylthio, halogen, nitro or amino disubstituted by alkyl, aralkyl or aryl, andR.sup.4 and R.sup.5, when they are adjacent, can be parts of a fused cycloaliphatic or aromatic ring,are described as well as methods for its preparation such as by reaction of an acetoacetic acid compound with a 3-nitro-aniline under condensation conditions, or, by reaction of an enamine with 3-nitro-phenyl isocyanate. The 3-nitro-acetoacetanilides are useful intermediates in the preparation of coupling components for color photography.

Abstract: An improved process for the preparation of .alpha.-amino-penicillins from an aqueous solution of a derivative of 6-APA and amide-type Dane salts.

Abstract: Vulcanizable rubber compositions are described which are inhibited from premature vulcanization by activated methylene di(thioethers) in which the adjacent activating groups are either carbonyl or cyano. Novel compounds are also described.

Abstract: Novel, transient prodrug forms of the phenolic dihydroxy sympathomimetic amines have (i) the structural formula (I): ##STR1## wherein X is O, S or NR.sup.5 ; n is 1 or 2; R.sup.1 is the monodehydroxylated residue of a phenolic, nuclear dihydroxy natural sympathetic or sympathomimetic amine when n is 1, and the didehydroxylated residue of a phenolic, nuclear dihydroxy natural sympathetic or sympathomimetic amine when n is 2; R.sup.

Abstract: Novel, transient prodrug forms of dopa and dopamine have (i) the structural formula (I): ##STR1## wherein each R is independently selected from the group consisting of hydrogen, R.sup.3 -CO- and ##STR2## wherein X is O, S or NR.sup.6 ; R.sup.1 is hydrogen or --COOR.sup.8 ; R.sup.2 is hydrogen or OR; R.sup.

Abstract: Amide-type Dane salts having the formula: ##STR1## wherein R is a group of the formula: ##STR2## wherein R.sub.2 is hydrogen and R.sub.3 is phenyl or substituted phenyl, R.sub.1 is cyano or nitro, and M is hydrogen, an alkali metal or a triloweralkylamine are disclosed, as well as a process for preparing .alpha.-aminopenicillins from these salts and 6-APA.

Abstract: Acyl anilines are disclosed having the formula ##STR1## wherein R and R.sup.1 (like or unlike each other)=H; CH.sub.3 ; C.sub.2 H.sub.5 ; n.C.sub.3 H.sub.7 ; --CH.sub.2 --CH.dbd.CH.sub.2 ; --CH.dbd.CH--CH.sub.3 ;R.sup.3 and R.sup.4 (like or unlike each other)=H; alkyl C.sub.1 -C.sub.3 ; halomethyl; Cl; F; CN; O-alkyl; S-alkyl; alkoxymethyl;or R.sup.3 and R.sup.4 together are (CH.sub.2 .dbd.) ##STR2## (R.sup.9 =alkyl C.sub.1 -C.sub.3); CN; --CH(OR.sup.5).sub.2 (R.sup.5 =alkyl or alkylidene ); ##STR3## (R.sup.6 and R.sup.7 =H, alkyl) `n=0,1 Z=phenyl optionally substituted; ##STR4## And R.sup.2 =H, CH.sub.3 ; m=1,2; Y=alkynyl C.sub.2 -C.sub.8 ; phenyl optionally substituted; phenyl-acetyl; furyl, thienyl; pyridyl; heterocyclic groups containing 2 or 3 heteroatoms, one of them different from nitrogen;R.sup.8 =CH.sub.3 ; alkoxymethyl; halomethy; O-alkyl.The compounds of formula I are endowed with a high fungicidal activity and with a low phytotoxicity.

Abstract: Monoazo compounds of the general formula ##STR1## in which R is hydrogen, methyl or ethyl. The monoazo compounds are valuable pigments which are especially useful for coloring baking varnishes and plastics. They also exhibit characteristics of good fastness to light, weathering, migration, especially overvarnishing and heat stability.

Abstract: Yellow pigments having a greenish hue are represented by the formula: ##STR1## wherein X.sub.1 and X.sub.2 may be the same or different from one another and each is hydrogen, halogen (chlorine, fluorine or bromine), lower alkyl or alkoxy having from 1 to 3 carbon atoms; and wherein R.sub.1 and R.sub.2 may be the same or different from one another and each is the residue from an acyl-acetyl-amino-aromatic coupling agent or the residue from a pyrazolone coupling agent. Pigments are obtained by coupling of (1) an aceto-acetyl-amino-aromatic compound or (2) of a pyrazoline, with a 4,4'-diamino-benzanilide. The yellow pigments have the characteristic of having a high tintorial yield, a high degree of purity of tone (brightness), a good fastness to light, and good resistance to organic solvents. These pigments are particularly useful in the polychrome graphic industry.