Halogen, Bonded Directly To Carbon, In Substituent Q Patents (Class 564/209)
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Patent number: 11028249Abstract: Methods and compositions are provided for synthesizing ionic liquids from lignin. Methods and compositions are also provided for treating lignin with ionic liquids.Type: GrantFiled: August 31, 2018Date of Patent: June 8, 2021Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Tanmoy Dutta, Blake Simmons, Seema Singh
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Patent number: 9199930Abstract: Disclosed herein a novel, process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline [(S)-1]. Particularly, the invention relates to the synthesis of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline with excellent selectivity starting from commercially available enantiopure (R)-epichlorohydrin [(R)-2] via formation of aziridine intermediate [(S)-4].Type: GrantFiled: September 6, 2013Date of Patent: December 1, 2015Assignee: Council of Scientific and Industrial ResearchInventors: Muthukrishnan Murugan, Prashant Pramod Mujumdar
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Patent number: 8981151Abstract: Fluorocarbon- and urethane-(meth)acryl-containing additives and hardcoats. The hardcoats are particularly useful as a surface layer on an optical device.Type: GrantFiled: April 8, 2014Date of Patent: March 17, 2015Assignee: 3M Innovative Properties CompanyInventors: Thomas P. Klun, Naiyong Jing, Richard J. Pokorny, Zai-Ming Qiu, Mark J. Pellerite, William D. Coggio, Christopher B. Walker, Jr.
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Publication number: 20140221689Abstract: Fluorocarbon- and urethane-(meth)acryl-containing additives and hardcoats. The hardcoats are particularly useful as a surface layer on an optical device.Type: ApplicationFiled: April 8, 2014Publication date: August 7, 2014Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: Thomas P. Klun, Naiyong Jing, Richard J. Pokorny, Zai-Ming Qiu, Mark J. Pellerite, William D. Coggio, Christopher B. Walker, Jr.
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Publication number: 20140148603Abstract: A method for preparing a fluorinated organic compound (II) from an organic compound (I) comprising at least one nucleofugal group Nu, and also a preparation of different specific organic compounds, in particular a fluoro-methylpyrazole compound. The method comprises: a reaction, in the presence of water, of the organic compound (I) and at least one salt providing at least one fluoride anion; and a replacement of at least one nucleofugal group Nu of the compound (I) with a fluorine atom, in order to obtain the fluorinated organic compound (II).Type: ApplicationFiled: May 29, 2012Publication date: May 29, 2014Applicant: RHODIA OPERATIONSInventors: Olivier Buisine, Michael Dejoux
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Patent number: 8710257Abstract: A method for preparing highly fluorinated carboxylic acids and theirs salts and the precursors thereof.Type: GrantFiled: November 18, 2010Date of Patent: April 29, 2014Assignee: 3M Innovative Properties CompanyInventors: Klaus Hintzer, Tilman C. Zipplies, Oleg Shyshkov
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Publication number: 20140012027Abstract: A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound.Type: ApplicationFiled: September 9, 2013Publication date: January 9, 2014Applicants: Taiyo Nippon Sanso Corporation, Kyoto UniversityInventors: Junichi YOSHIDA, Aiichiro NAGAKI
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Patent number: 8609857Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.Type: GrantFiled: May 14, 2012Date of Patent: December 17, 2013Assignee: Intezyne Technologies, Inc.Inventors: Kurt Breitenkamp, Kevin Sill, Habib Skaff
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Patent number: 8461386Abstract: The present invention relates to a process for the asymmetric hydrogenation of imines with hydrogen under elevated pressure in the presence of a catalyst system. In particular the present invention relates to the use of the said catalytic system for the enantioselective hydrogenation of prochiral ketimines to asymmetric amines leading to the formation of herbicides.Type: GrantFiled: April 16, 2009Date of Patent: June 11, 2013Assignee: United Phosphorus LimitedInventors: Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff, Birja Shanker
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Publication number: 20120226050Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.Type: ApplicationFiled: May 14, 2012Publication date: September 6, 2012Applicant: Intezyne Technologies, Inc.Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
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Patent number: 8247612Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods represented by the formula (I): wherein, R1 represents a C1-C5 haloalkyl group having at least one fluorine atom, R2 represents a C1-C4 alkyl group optionally substituted with at least one halogen atom or the like, R3 represents a hydrogen atom or the like, R4 represents a cyano group or the like, R5 represents a hydrogen atom or the like, m represents an integer of 1 to 4, and n represents 0, 1 or 2.Type: GrantFiled: May 16, 2008Date of Patent: August 21, 2012Assignee: Sumitomo Chemical Company, LimitedInventor: Hiroyuki Miyazaki
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Publication number: 20120190879Abstract: The present invention pertains to a method for the hydrochlorination of electron deficient alkenes, particularly alkenes having the functional groups COOH, CONH2, and CN. Specific alkenes discussed include acrylic acid, crotonic acid, methacrylic acid, acrylonitrile, acrylamide, and methacrylonitrile. The alkene is combined with a primary or secondary alcohol (e.g., isopropanol) and an acid chloride (e.g., acetyl chloride) under conditions suitable to chlorinate the alkene. Products formed by the invention include 3-chorosubstituted carbonyl compounds such as 3-chlorpropionic acid (3-CPA), 3-chloropropionamide (3-CPAD), and 3-chloropropionitrile among other products.Type: ApplicationFiled: January 24, 2011Publication date: July 26, 2012Inventor: Michael Todd Coleman
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Publication number: 20120148690Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.Type: ApplicationFiled: December 10, 2010Publication date: June 14, 2012Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
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Publication number: 20120101287Abstract: The invention related to an optically active compound of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use as herbicides or plant growth regulators. The invention also relates to novel intermediates of formula (III), (V) and (XIII) as defined in the description.Type: ApplicationFiled: December 28, 2011Publication date: April 26, 2012Applicant: Bayer CropScience AGInventors: Hartmut Ahrens, Hansjöerg Dietrich, Klemens Minn, Thomas Auler, Hermann Bieringer, Martin Hills, Heinz Kehne, Hubert Menne
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Patent number: 8158829Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods which is represented by formula (I): wherein R1 represents a C3-C6 haloalkyl group having at least one fluorine atom and at least one atom selected from group consisting of a chlorine atom, a bromine atom and an iodine atom, R2 represents a cyano group and the like, R3 represents a hydrogen atom, a halogen atom or a C1-C4 alkyl group, R4 represents a C1-C5 fluoroalkyl group, and n represents 0, 1 or 2.Type: GrantFiled: May 16, 2008Date of Patent: April 17, 2012Assignee: Sumitomo Chemical Company, LimitedInventor: Hiroyuki Miyazaki
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Patent number: 8084643Abstract: The present invention discloses certain novel prodrugs of florfenicol and/or of florfenicol analogs, including prodrugs of salts pharmaceutically acceptable salts of florfenicol and its analogs, including nitrogen-containing esters of the secondary alcohol group of florfenicol and of its analogs, and pharmaceutically acceptable salts thereof, compositions containing them, and methods of administering them to subjects. In particular embodiments the prodrugs are sufficiently water-soluble to serve the functions needed of a water-soluble prodrug of florfenicol or of a water-soluble prodrug of a florfenicol analog. A certain subclass of the compounds also possesses the hydrolytic stability needed to maintain the prodrug in solution in the subject's system until appropriate conditions exist when the prodrug can hydrolyze, releasing florfenicol or the florfenicol analog in question.Type: GrantFiled: December 11, 2007Date of Patent: December 27, 2011Assignee: Intervet Inc.Inventors: Tomasz W. Glinka, Jason Z. Zhang
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Publication number: 20110060144Abstract: A method for manufacturing amidomagnesium halogenides and admixtures thereof with alkali metal salts in aparotic, organic solvents, compounds obtained according to the method and use thereof in synthesis chemistry, for example for deprotonizing enolizable systems, functionalized aromatics and heteroaromatics.Type: ApplicationFiled: May 18, 2009Publication date: March 10, 2011Inventors: Alexander Murso, Christopher Kurth, Peter Rittmeyer
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Publication number: 20110054217Abstract: The present invention relates to a process for the asymmetric hydrogenation of imines with hydrogen under elevated pressure in the presence of a catalyst system. In particular the present invention relates to the use of the said catalytic system for the enantioselective hydrogenation of prochiral ketimines to asymmetric amines leading to the formation of herbicides.Type: ApplicationFiled: April 16, 2009Publication date: March 3, 2011Applicant: UNITED PHOSPHORUS LIMITEDInventors: Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff, Birja Shanker
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Publication number: 20100286073Abstract: The present invention relates to compounds, as well as to compositions, methods and kits comprising such compounds, for use in the treatment or prophylaxis of fibromyalgia, chronic fatigue syndrome, myofascial pain syndrome, Gulf War syndrome and related conditions, wherein the compound is a fatty acid oxidation inhibitor and/or a carbohydrate oxidation activator.Type: ApplicationFiled: October 3, 2008Publication date: November 11, 2010Inventor: Paul JENKINS
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Publication number: 20100209780Abstract: A battery that includes a cathode, anode and an electrolytic solution containing an organic electrolyte solvent including a compound of the formula: R1—CO—NR2—OR3 wherein R1 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives and perfluorinated analogues; R2 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives; R3 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives wherein the electrolyte is stable at voltages of greater than 4.0 volts.Type: ApplicationFiled: February 17, 2009Publication date: August 19, 2010Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Synthonix Corporation, Toyota Motor CorporationInventors: John Muldoon, Gary Allred, Scott Ankeney, Masaki Matsui, Anthony Dotse, Tsuyoshi Sugimoto
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Publication number: 20100160430Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods represented by the formula (I): wherein, R1 represents a C1-C5 haloalkyl group having at least one fluorine atom, R2 represents a C1-C4 alkyl group optionally substituted with at least one halogen atom or the like, R3 represents a hydrogen atom or the like, R4 represents a cyano group or the like, R5 represents a hydrogen atom or the like, m represents an integer of 1 to 4, and n represents 0, 1 or 2.Type: ApplicationFiled: May 16, 2008Publication date: June 24, 2010Inventor: Hiroyuki Miyazaki
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Publication number: 20100152289Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods which is represented by formula (I): wherein R1 represents a C3-C6 haloalkyl group having at least one fluorine atom and at least one atom selected from group consisting of a chlorine atom, a bromine atom and an iodine atom, R2 represents a cyano group and the like, R3 represents a hydrogen atom, a halogen atom or a C1-C4 alkyl group, R4 represents a C1-C5 fluoroalkyl group, and n represents 0, 1 or 2.Type: ApplicationFiled: May 18, 2008Publication date: June 17, 2010Inventor: Hiroyuki Miyazaki
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Patent number: 7638650Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a covalent bond, —O— or —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is an alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups; R is hydrogen or a C1 to C4 alkyl; and Ro1 is an aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens; provided that 1) when Y is —(CH2)nRf, Ro is Ro1; 2) when X is hydrogen, Y is —CH2CH(CF3)2; and 3) when X is —(CH2)nRf and Y is —(CH2)nRf, Ro is Ro1.Type: GrantFiled: August 6, 2007Date of Patent: December 29, 2009Assignee: E.I. du Pont de Nemours and CompanyInventor: Weiming Qiu
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Publication number: 20090186941Abstract: A compound given by the formula (I): has an excellent controlling activity against noxious arthropods.Type: ApplicationFiled: November 1, 2006Publication date: July 23, 2009Inventor: Hiroyuki Miyazaki
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Publication number: 20090143621Abstract: A method of forming an alkoxylated fluoroalcohol is accomplished by providing a boron compound having or providing at least one boron-oxygen bond and an iodine source. The boron compound and iodine source are combined with reactants of a fluoroalcohol and an alkylene oxide in the presence of a base. The reactants are allowed to react to form an alkoxylated fluoroalcohol reaction product.Type: ApplicationFiled: December 1, 2008Publication date: June 4, 2009Inventor: Thomas Joseph Martin
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Publication number: 20090074673Abstract: The disclosure provides, in part, compositions and methods for producing cellular labels for tracking cells by MRI. The disclosure provides, in part, methods for labeling, detecting and quantifying cell numbers in vivo.Type: ApplicationFiled: July 10, 2008Publication date: March 19, 2009Applicant: Carnegie Mellon UniversityInventors: Jelena Janjic, Eric T. Ahrens
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Publication number: 20090043130Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a divalent radical selected from the group consisting of a covalent bond, —O— and —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated linear or branched alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is a linear or branched alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups selected from the group consisting of —O—, —OH, —NR—, —N(R)2, and —C(O)NR—, wherein a) the ratio of hydrophilic groups to carbon atoms is from about 1:2 to about 1:10; b) each carbon atom has at most one hydrophilic group bonded to it, and c) covalent bonding between hydrophilic groups is absent; R is hydrogen or a C1 to C4 linear or branched alkyl; and Ro1 is a linear or branched aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 eType: ApplicationFiled: August 6, 2007Publication date: February 12, 2009Inventor: Weiming Qiu
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Publication number: 20080113172Abstract: Partially fluorinated amino acid derivatives are provided that are useful as organogelators and surface treatment materials to provide oil- and water-repellency properties to substrates. Also provided are composite materials comprising a porous support and a porous nanoweb. The porous nanoweb contains fibrous structures of about 10 nm to about 1000 nm effective average fiber diameter.Type: ApplicationFiled: November 13, 2006Publication date: May 15, 2008Inventors: Erick Jose Acosta, Anilkumar Raghavanpillai, Sheng Peng, Stefan Reinartz
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Patent number: 7361689Abstract: Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3, CH2N3, CH2CN, CH(R2)NH2 or CH X1X2; where R2 is H, CH3 or CH2OH, and X1 and X2 are independently selected halogens; and R3 is CH2Cl, CH2F, CHF2, CHCl2 or CH2OH are disclosed. The compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.Type: GrantFiled: December 21, 2004Date of Patent: April 22, 2008Assignee: Schering-Plough Animal Health CorporationInventors: Dale E. Shuster, Scott Hecker, Tomasz W. Glinka, Rajeshwar Singh, Zhuoyi Su
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Patent number: 6924397Abstract: The present invention relates to a process for the preparation of ?-chloroketones from readily available alkyl esters by the reaction of a sulfoxonium ylide on said alkyl esters to generate a keto sulfoxonium ylide that is in turn treated with anhydrous HCl.Type: GrantFiled: October 22, 2003Date of Patent: August 2, 2005Assignee: Bristol-Myers Squibb CompanyInventors: William Aloysius Nugent, Dengjin Wang
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Patent number: 6689910Abstract: Olefins containing selected functional groups such as silyl, ether and alkenyl, and often containing a blocking group, may be copolymerized with unsubstituted olefins such as ethylene and propylene in the presence of certain coordination compounds of nickel or palladium. The resulting polymers are useful as molding resins, elastomers, in adhesives and for films.Type: GrantFiled: May 12, 2003Date of Patent: February 10, 2004Assignee: E. I. du Pont de Nemours and CompanyInventors: Lin Wang, Samuel David Arthur, Elizabeth Forrester McCord, Yueli Wang, Peter Arnold Morken, Lynda Kaye Johnson
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Publication number: 20040024243Abstract: The present invention relates to a fluorination method for the synthesis of halofluoroorganic compounds which can be used, inter alia, as precursors in the synthesis of 2,3-unsaturated fluoroorganic carbonyl compounds comprising a fluorine substituent in the 2 position.Type: ApplicationFiled: February 5, 2003Publication date: February 5, 2004Inventors: Veronique Mathieu, Francine Janssens, James Franklin
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Patent number: 6649719Abstract: Described is a compound having at least one acrylate monomer, said monomer including at least one pendant group of the structure —O—CH(Rf)(Rf′), wherein Rf is a straight chain or branched perfluoroalkyl group with five or less carbon atoms, and Rf′ is a branched perfluoroalkyl group with three to five carbon atoms; and a method of reducing the surface tension of a liquid by adding a compound of the invention to the liquid. Also described is a composition that includes a compound of the invention in an aqueous solution or dispersion; a method of treating a substrate to render it oil- and/or water-repellent that includes treating a substrate with a composition of the invention; a method of coating an electrical device that includes applying a composition of the invention; a method of coating optical fibers that includes applying a composition of the invention; and an article that includes a substrate treated with a composition of the invention.Type: GrantFiled: August 16, 2001Date of Patent: November 18, 2003Assignee: 3M Innovative Properties CompanyInventors: George G. I. Moore, Michael A. Yandrasits, Jay F. Schulz, Richard M. Flynn
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Patent number: 6388133Abstract: A process for the preparation of an N,N-disubstituted-2-fluoro-1,3-ketoamide having the formula RCO.CFR′CONR2″ comprises treating an N,N-disubstituted-1,3-ketoamide having the formula RCO.CHR′CONR2″ with elemental fluorine. The groups R, R′ and R″ are independently selected from alkyl, aryl, substituted aryl, cycloalkyl, and substituted cycloalkyl. The group R′ may also be nitro or chlorine.Type: GrantFiled: December 9, 1999Date of Patent: May 14, 2002Assignee: F2 Chemicals LimitedInventors: Richard Dickinson Chambers, John Hutchinson, Julie Thomson
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Patent number: 6376705Abstract: Esters and other carboxylic acid derivatives of 3,3,4,4-tetrahydroperfluoroalkylcarboxylic acids are made by the iron promoted reaction of an ester of bromodifluoroacetic acid or other carboxylic acid derivatives and a (perfluoroalkyl)ethylene. The resulting products may be converted to the corresponding alkali metal or ammonium carboxylate slits which are useful as surfactants in fluoroolefin polymerizations.Type: GrantFiled: May 22, 2000Date of Patent: April 23, 2002Assignee: E. I. du Pont de Nemours and CompanyInventor: Weiming Qiu
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Patent number: 6365769Abstract: Novel mixtures of perfluoroalkyl halides and derivatives thereof are described. These mixtures contain some compounds with a straight perfluoroalkyl group and some with a branched perfluoroalkyl group. Methods of preparation and use are also described.Type: GrantFiled: February 15, 2000Date of Patent: April 2, 2002Assignee: 3M Innovative Properties CompanyInventors: Frederick E. Behr, Rudolf J. Dams, Johan E. DeWitte, Donald F. Hagen
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Patent number: 6353012Abstract: HETE derivatives and methods of their use for treating dry eye are disclosed.Type: GrantFiled: October 23, 2000Date of Patent: March 5, 2002Assignee: Alcon Universal Ltd.Inventors: Mark R. Hellberg, John M. Yanni, Gustav Graff, Daniel A. Gamache, Peter G. Klimko
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Patent number: 6251882Abstract: Novel alkyl ketone compounds having potent cytotoxic activity are described as anti-tumor agents and are particularly effective against leukemia and breast tumor cells.Type: GrantFiled: June 29, 1999Date of Patent: June 26, 2001Assignee: Parker Hughes InstituteInventors: Fatih M. Uckun, Rama Krishna Narla, David Alan Perry
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Patent number: 6197987Abstract: The present invention relates to chemically stable, polyfunctional, perfluorinated polyorganosiloxanes (POS) comprising on the one hand fluorinated lateral grafts resulting from the hydrosilylation of perfluorinated olefins with SiH units and having alkyl and/or alkyl ester linkages but not ether linkages, and on the other hand other, non-perfluorinated functional units E capable of giving them diverse and varied physical and chemical properties and opening up avenues in numerous applications. Examples of these POS according to the invention are those of the following formula: According to another of its features, the invention relates to a process for the preparation of these polyfunctional perfluorinated POS. Applications: antifoams, agents for lowering surface tension, dirt repellents, antiadhesives, lubricants, oleophobic and/or hydrophobic agents, coatings etc.Type: GrantFiled: February 9, 1999Date of Patent: March 6, 2001Assignee: Rhone-Bouling ChimieInventors: Philippe Jost, Philippe Karrer, Gérard Mignani, Philippe Olier
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Patent number: 6096762Abstract: The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel .alpha.,.alpha.-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.Type: GrantFiled: May 21, 1999Date of Patent: August 1, 2000Assignee: Bristol-Myers Squibb CompanyInventors: Vivekananda M. Vrudhula, Gene M. Dubowchik, Bireshwar Dasgupta, Dolatrai M. Vyas
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Patent number: 6054615Abstract: Selected quaternary ammonium salts containing fluoroalkyl, preferably perfluoroalkyl, groups that are stable to bases are described. They are useful as phase transfer reaction catalysts, especially in basic media.Type: GrantFiled: May 27, 1999Date of Patent: April 25, 2000Assignee: E.I. du Pont de Nemours and CompanyInventor: Weiming Qiu
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Patent number: 6013795Abstract: Briefly, in one aspect, the present invention provides compositions of open-chain, .alpha.-branched fluoroalkylcarbonyl fluorides, and derivatives thereof.Type: GrantFiled: November 4, 1996Date of Patent: January 11, 2000Assignee: 3M Innovative Properties CompanyInventors: Anthony P. Manzara, Wei-Qiang Fan, Richard M. Stern, George G. I. Moore
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Patent number: 5968963Abstract: Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A.sub.2 (PLA.sub.2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.Type: GrantFiled: March 4, 1996Date of Patent: October 19, 1999Assignee: Warner-Lambert CompanyInventor: Reynold Homan
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Patent number: 5932595Abstract: The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.Type: GrantFiled: December 18, 1996Date of Patent: August 3, 1999Assignees: Syntex (U.S.A.) Inc., Agouron Pharmaceuticals, Inc.Inventors: Steven Lee Bender, Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Lawrence Emerson Fisher, Robert Than Hendricks, Keshab Sarma
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Patent number: 5880160Abstract: The present invention relates to novel colchicine derivatives having antiproliferative, antineoplastic, antiinflammatory and muscle relaxant activities; said derivatives include novel colchine nitrogen amides for use either as such or after derivatization of the hydroxyl at C.sub.3 of the aromatic ring and at C.sub.10 of the tropolone ring. These novel compounds have a cytotoxicity on human tumoral cell lines comparable with colchicine but, in comparison with the latter, they are much more active on cells resistant to the usual antiblastics. The compounds can be included in pharmaceutical formulations useful for the intravenous, oral and topical administrations.Type: GrantFiled: June 27, 1996Date of Patent: March 9, 1999Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Bruno Gabetta
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Patent number: 5820665Abstract: An object of the present invention is to provide a compound which imparts a sufficient water repellency and a suitable oil repellency to substrates such as a fiber, a paper, a wood material, a hide, a leather, a resin, a glass, a metal, etc. The compound of the present invention is a fluoroalkylcarboxylic acid of the general formula (I), and its derivative of the general formula (II) (e.g. fluoroalkyl alcohol, fluoroalkyl carboxylic acid chloride, fluoroalkylcarboxylic acid amide and fluoroalkylamine).Type: GrantFiled: May 28, 1997Date of Patent: October 13, 1998Assignee: Matsushita Electric Industrial Co., Ltd.Inventor: Yoshiaki Kai
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Patent number: 5786515Abstract: A simple, high yielding synthesis of a-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-N-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N,O-dimethylhydroxylamine.Type: GrantFiled: August 30, 1996Date of Patent: July 28, 1998Assignee: Merck & Co., Inc.Inventors: Ulf H. Dolling, Lisa F. Frey, Richard D. Tillyer, David M. Tschaen
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Patent number: 5756728Abstract: An improved process for preparing 1,1'-?1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-?1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane.Type: GrantFiled: December 30, 1996Date of Patent: May 26, 1998Assignee: Johnson Matthey Public Limited CompanyInventors: David Xu, Prasad Kapa, Oljan Repic, Thomas J. Blacklock
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Patent number: 5753709Abstract: Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.Type: GrantFiled: May 9, 1996Date of Patent: May 19, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Daniel J. Keavy, Michael F. Parker, Ronald J. Mattson, Graham Johnson
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Patent number: RE38506Abstract: The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R1 and R2 are different, R1=R3—N—R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells.Type: GrantFiled: November 2, 2001Date of Patent: April 20, 2004Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New YorkInventors: Ronald Breslow, Paul A. Marks, Richard A. Rifkind, Branko Jursic