Hydrazones (i.e., Hch=n-hnh, Wherein Substitution May Be Made For Hydrogen Only) Patents (Class 564/250)
  • Patent number: 11799214
    Abstract: A connection arrangement comprising a metallic flat conductor having an at least quadrangular cross-sectional profile and at least two opposing surfaces extending longitudinally parallel to each other at least in an end region, a first through-opening between the surfaces in the end region, the first through-opening being formed for receiving a bolt, at least one second through-opening between the surfaces in the end region, the second through-opening being formed to receive a metallic terminal, the terminal being formed as a flat part and bearing flatly with a contact surface against one of the surfaces of the flat conductor in the end region.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: October 24, 2023
    Assignee: Auto-Kabel Management GmbH
    Inventors: Marie Redder, Oliver Scharkowski
  • Patent number: 8916183
    Abstract: This document discloses molecules having the following formulas (“Formula One” &“Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: December 23, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Lindsey G. Fischer, Gary D. Crouse, Thomas C. Sparks, Erich W. Baum
  • Patent number: 8858991
    Abstract: Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: October 14, 2014
    Assignee: Pathologica LLC
    Inventors: John McKearn, Jeremy Blitzer
  • Publication number: 20130172556
    Abstract: The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification.
    Type: Application
    Filed: September 7, 2011
    Publication date: July 4, 2013
    Inventors: Markus Jachmann, Takayuki Wakamatsu, Mitsuharu Anryu
  • Publication number: 20130023668
    Abstract: The present invention relates to novel processes for the production of compounds of formula wherein Hal and Hal? are independently selected from Cl and F, and R1 is selected from Cl, F and H.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 24, 2013
    Applicant: SYNGENTA CROP PROTECTION, LLC
    Inventor: Syngenta Crop Protection, LLC
  • Patent number: 8269020
    Abstract: The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal? are independently selected from Cl and F, and R1 is selected from Cl, F and H.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: September 18, 2012
    Assignee: Syngenta Crop Protection LLC
    Inventors: Martin Charles Bowden, Brian David Gott, Iacob Eremia Gutu, David Anthony Jackson
  • Publication number: 20110293553
    Abstract: Compounds, compositions, kits, devices, and methods of attracting, detecting, eradicating, controlling, or killing an insect, such as a bed bug, by utilizing insect attractant, arresting, and/or aggregation compounds and compositions is provided. Insect attractant, arresting, and/or aggregation compounds identified from insect fecal extract by an analytical technique, such as gas chromatography, nuclear magnetic resonance (NMR), Carbon-13 NMR, mass spectroscopy, LC-MS, GC-MS, high performance liquid chromatography (HPLC), or combinations thereof are provided. A bed bug attractant, arresting, and/or aggregation compound identified from bed bug feces and exhibiting a Carbon-13 NMR peak at about ? 159.453 ppm is also provided.
    Type: Application
    Filed: May 28, 2010
    Publication date: December 1, 2011
    Inventors: Tai-Teh Wu, Kenneth Haynes, Joe Harold Hope, III
  • Patent number: 7812113
    Abstract: A monomer with a chromophore group represented by Formula (I): wherein AR1 represents a substituted or unsubstituted aromatic group; AR2 represents a substituted or unsubstituted aromatic group or a substituted or unsubstituted alkyl group; and R represents a substituted or unsubstituted alkyl group, with the proviso that one of R, AR1, and AR2 has a substituent with a polymerizable functional group. The monomer can be advantageously used to prepare polymeric dispersants for pigment dispersion, especially inkjet inks.
    Type: Grant
    Filed: July 4, 2006
    Date of Patent: October 12, 2010
    Assignee: Agfa Graphics NV
    Inventors: Geert Deroover, Wojciech Jaunky, Lambertus Groenendaal, Johan Loccufier
  • Publication number: 20100240907
    Abstract: The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal? are independently selected from Cl and F, and R1 is selected from Cl, F and H.
    Type: Application
    Filed: June 16, 2008
    Publication date: September 23, 2010
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Martin Charles Bowden, Brian David Gott, David Anthony Jackson, Lacob Gutsu
  • Patent number: 7794907
    Abstract: A hydrazone compound capable of realizing an electrophotographic photoreceptor having good electric properties such as good sensitivity and light responsibility, good electric and mechanical durability and good environment stability, is provided. The hydrazone compound is represented by the following general formula (1). The compound is contained in the charge transporting layer of the electrophotographic photoreceptor.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: September 14, 2010
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Akihiro Kondoh, Takatsugu Obata
  • Patent number: 7582799
    Abstract: The present invention provides an industrially advantageous process for producing hydrazone derivative represented by the formula (5), which is shown by the following reaction formula.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: September 1, 2009
    Assignees: Shiratori Pharmaceutical Co., Ltd., Asubio Pharma Co., Ltd.
    Inventors: Hiroshi Yoshino, Kentaro Kobayashi, Yuichi Shiro
  • Publication number: 20090076305
    Abstract: The present invention provides an industrially advantageous process for producing hydrazone derivative represented by the formula (5), which is shown by the following reaction formula.
    Type: Application
    Filed: April 27, 2006
    Publication date: March 19, 2009
    Applicants: Shiratori Pharmaceutical Co., Ltd., Asubio Pharma Co., Ltd.
    Inventors: Hiroshi Yoshino, Kentaro Kobayashi, Yuichi Shiro
  • Patent number: 7479357
    Abstract: An organophotoreceptor that includes: (a) a charge transport material having the formula wherein A is selected from heterocyclic groups, naphthyl group, alkylsulfonylphenyl, stilbenyl or the group X, wherein X is represented by the formula B is selected from hydrogen, alkyl group, and an aryl group, with the proviso that when A is naphthyl, B is naphthyl; or where R1 is selected from the group consisting of N-pyrrolyl, N-pyrazolyl, N-tetrazolyl, N-indolyl, N-carbazolyl, N-triazolyl, N-imidazolyl, N-benzimidazolyl, N-indazolyl, and N-benzotriazolyl group, and R3 is a 9-fluorenone group. (b) a charge generating compound; and (c) an electrically conductive substrate.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: January 20, 2009
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kam W. Law, Nusrallah Jubran, Zbigniew Tokarski, Alan R. Katritzky, Ritu Jain, Rexiat Maimait, Anatoliy V. Vakulenko
  • Publication number: 20080268537
    Abstract: The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
    Type: Application
    Filed: July 7, 2008
    Publication date: October 30, 2008
    Applicant: The Regents of the University of California
    Inventors: Bruce N. Ames, Hani Atamna
  • Publication number: 20080227787
    Abstract: There is provided a use of a compound of formula (I), wherein R1, R2, R3 and R4 have meanings given in the description, and pharmaceutically-acceptable salts thereof, for the manufacture of a medicament for the treatment of a disease in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 18, 2008
    Inventors: Kristofer Olofsson, Benjamin Pelcman, Peter Nilsson, Anders Hallberg, Wesley Schaal
  • Patent number: 7074959
    Abstract: Methods of and systems for remediating hydrazine spills, solutions and hydrazine-contaminated objects including areas thereof. Initially, an aqueous solution comprising a dicarbonyl-compound can be prepared. The aqueous solution can then be provided for application to an object contaminated with a hydrazine group compound. The hydrazine group compounds are converted to a stable organic compound as a result of a reaction of the dicarbonyl-compound and hydrazine group compound. Conversion assists in the remediation of the hydrazine group compound from the object. The stable organic compound produced as a result of the reaction between the dicarbonyl-compound and hydrazine group compound can then be treated with a metal catalyst and hydrogen to produce glutamine or a derivative thereof. Both the stable organic compound and glutamine can undergo microbiological degradation without further remedial intervention.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: July 11, 2006
    Assignee: New Mexico Highlands University
    Inventors: Merritt C. Helvenston, Rudolfo A. Martinez, Jose C De Baca, John J. Juarez
  • Patent number: 6818794
    Abstract: Process for extracting aqueous ketazine solutions which is carried out using an aqueous ketazine solution having a salt content of 5 to 27% by weight and an ammonia content of 0 to 28% by weight to extract at temperatures of 50 to 120° C., which is characterized in that the ketazine solution to be extracted has a molar excess of 50 to 200% of ketone based on the ketazine to be extracted, and that an aliphatic hydrocarbon extractant is used which has a boiling point of 150 to 300° C. at atmospheric pressure.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: November 16, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ottfried Schlak, Hans-Georg Adams, Johannes Kaulen
  • Patent number: 6759554
    Abstract: The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: July 6, 2004
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L. Buchwald, Artis Klapars, Jon C. Antilla, Gabriel E. Job, Martina Wolter, Fuk Y. Kwong, Gero Nordmann, Edward J. Hennessy
  • Patent number: 6706895
    Abstract: Disclosed herein is a compound having the formula: wherein R1 is alkyl and R2 and R3 are independently selected aryl groups. Also disclosed is a method of making bifenazate using the compound as an intermediate.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: March 16, 2004
    Assignees: Uniroyal Chemical Company, Inc., Crompton Co./Cie
    Inventors: Sheldon B. Park, Gaik-Lean Chee, Mark A. Dekeyser
  • Publication number: 20040024251
    Abstract: Methods of and systems for remediating hydrazine spills, solutions and hydrazine-contaminated objects including areas thereof. Initially, an aqueous solution comprising a dicarbonyl-compound can be prepared. The aqueous solution can then be provided for application to an object contaminated with a hydrazine group compound. The hydrazine group compounds are converted to a stable organic compound as a result of a reaction of the dicarbonyl-compound and hydrazine group compound. Conversion assists in the remediation of the hydrazine group compound from the object. The stable organic compound produced as a result of the reaction between the dicarbonyl-compound and hydrazine group compound can then be treated with a metal catalyst and hydrogen to produce glutamine or a derivative thereof. Both the stable organic compound and glutamine can undergo microbiological degradation without further remedial intervention.
    Type: Application
    Filed: August 1, 2002
    Publication date: February 5, 2004
    Inventors: Merritt C. Helvenston, Rodolfo A. Martinez, Jose C De Baca, John J. Juarez
  • Patent number: 6610715
    Abstract: The present invention provides novel cathecol hydrazone derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein R1 is C1-7 alkyl or C3-7 cycloalkyl; R2 is hydrogen, hydroxy, C1-5 alkyl or —CH2CH2C(═O)NH2; R3 and R4 are independently hydrogen, C1-7 alkyl, —C(═X)—R5, or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one or two selected from a group consisting of halogen, C1-6 alkoxy, nitro, trifluoromethyl, C1-6 alkyl and carboxyl, or R3 and R4 are directly bonded by C3-4 containing oxygen, sulfur or nitrogen to form a heterocyclic ring, X is oxygen, sulfur or NH and R5 is C1-7 alkyl, —NHR6, CONH2 or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one selected from a group consisting of halogen, C1-6 alkoxy, nitrile, trifluoromethyl, C1-6 alkyl and carboxyl, and R6 is hydrogen, hydroxy, NH2, C1-5 alkoxy, C1-5 alkyl, pyridyl or phenyl.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: August 26, 2003
    Assignee: Cheil Jedang Corporation
    Inventors: Yong Sik Youn, Myung Xik Xiang, Byoung Chol Suh, Jong Hoon Kim, Kwang Hyuk Lee, Eui Kyung Kim, Jae Kyu Shin, Chung Keun Rhee
  • Patent number: 6587251
    Abstract: An electrochromic solution includes a hydrazone compound as an anodic compound is disclosed. The hydrazone compound has a general formula (I) wherein R1, R2, R3, and R4 are individually selected from a group consisting of hydrogen, alkyl containing 5 to 20 carbon atoms, alkenyl containing 2 to 20 carbon atoms, alkynyl containing 2 to 20 carbon atoms, and aryl containing 5 to 20 atoms which are unsubstituted or optionally substituted with one or more ester, ether, aryl, amine, thioester, alkyl, alkoxy, alkene, alkyne, CN, F, Cl, Br, I and/or organometallcene functional group.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: July 1, 2003
    Assignee: Exon Science, Inc.
    Inventors: Fu-Shing Wang, Kuang-Mei Hsu
  • Publication number: 20030105355
    Abstract: Process for extracting aqueous ketazine solutions which is carried out using an aqueous ketazine solution having a salt content of 5 to 27% by weight and an ammonia content of 0 to 28% by weight to extract at temperatures of 50 to 120° C., which is characterized in that the ketazine solution to be extracted has a molar excess of 50 to 200% of ketone based on the ketazine to be extracted, and that an aliphatic hydrocarbon extractant is used which has a boiling point of 150 to 300° C. at atmospheric pressure.
    Type: Application
    Filed: November 27, 2002
    Publication date: June 5, 2003
    Inventors: Ottfried Schlak, Hans-Georg Adams, Johannes Kaulen
  • Patent number: 6567204
    Abstract: An electrochromic solution includes a hydrazone compound as an anodic compound is disclosed. The hydrazone compound has a general formula (I) wherein R1, R2, R3 and R4 are individually selected from a group consisting of hydrogen, alkyl containing 5 to 20 carbon atoms, alkenyl containing 2 to 20 carbon atoms, alkynyl containing 2 to 20 carbon atoms, and aryl containing 5 to 20 carbon atoms which are unsubstituted or optionally substituted with one or more ester, ether, aryl, amine, thioester, alkyl, alkoxy, alkene, alkyne, CN, F, Cl, Br, I and/or organometallcene functional group.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: May 20, 2003
    Assignee: Exon Science, Inc.
    Inventors: Fu-Shing Wang, Kuang-Mei Hsu
  • Patent number: 6465693
    Abstract: A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: October 15, 2002
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L. Buchwald, Seble Wagaw, O. Geis
  • Patent number: 6420362
    Abstract: The present invention is directed to compounds of having the formula (I) in which G represents a single bond or a grouping  and Z represents alkyl or halogenoalkyl or cycloalkyl or cycloalkylalkyl or heterocyclyl or heterocyclylalkyl or aryl or arylalkyl and L1, L2, L3 and L4 are identical or different and independently of one another in each case represent hydrogen, halogen, cyano, nitro or in each case optionally halogen-substituted alkyl, alkoxy, alkylthio, alkylsulphinyl or alkylsulphonyl having in each case 1 to 6 carbon atoms and in each case optionally substituted by 1 to 5 halogen atoms. The invention also relates to the preparation of such compounds and the use of such compounds to combat plant fungi and plant bacteria.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: July 16, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd-Wieland Krüger, Herbert Gayer, Klaus Stenzel, Gerd Hänssler, Astrid Mauler-Machnik, Stefan Hillebrand
  • Publication number: 20010031894
    Abstract: A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.
    Type: Application
    Filed: January 18, 2001
    Publication date: October 18, 2001
    Inventors: Stephen L. Buchwald, Seble Wagaw, Oliver Fabian Geis
  • Patent number: 6265613
    Abstract: Phenylacetic acid derivatives of the formula I where the substituents and the indexes have the meanings given in the specification, their salts, their preparation and their use.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: July 24, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Müller, Hubert Sauter, Herbert Bayer, Wassilios Grammenos, Thomas Grote, Reinhard Kirstgen, Klaus Oberdorf, Franz Röhl, Norbert Götz, Michael Rack, Ruth Müller, Gisela Lorenz, Eberhard Ammermann, Siegfried Strathmann, Volker Harries
  • Patent number: 6242207
    Abstract: A dry chemistry reagent matrix composition is provided containing a matrix material and a reagent composition containing 3-methyl-6(sulfonate salt)-benzothiazolinone-(2)-hydrazone (MBTH-S), N-ethyl-N-(3-sulfopropyl)aniline, and an oxidase enzyme or a peroxidase enzyme or a mixture thereof. The dry chemistry reagent matrix composition is useful in reagent test strips for determining the presence or concentration of an analyte in a fluid sample, such as blood.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: June 5, 2001
    Assignee: Amira Medical
    Inventors: Joel S. Douglas, Karen R. Drexler, John M. Gleisner, John H. Priest
  • Patent number: 6235936
    Abstract: A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: May 22, 2001
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L. Buchwald, Seble Wagaw, Oliver Fabian Geis
  • Patent number: 6153789
    Abstract: The present invention provides a method of purifying an aqueous dye solution having an aldehyde and/or ketone impurity including a step of reacting the impurity with a hydrazine derivative, forming a water-insoluble hydrazone compound. The hydrazone compound is then removed from the solution to form a dye having an increased purity.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: November 28, 2000
    Assignee: BASF Corporation
    Inventors: Kevin P. Cusack, Kwang Kim, Dennis L. Edie, Benjamin S. Tennyson
  • Patent number: 6040151
    Abstract: A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S). A preferred dye systems are based on the dye couple (MBTH-S) and 8-anilino-1-naphthalenesulfonate (ANS), and the dye couple MBTH-S and N-(3-sulfopropyl)analine. These dye indicator systems are used in conventional blood chemistry test strips and are particularly preferred for indication of glucose in blood.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: March 21, 2000
    Assignee: Mercury Diagnostics, Inc.
    Inventors: Joel S. Douglas, Karen R. Drexler
  • Patent number: 6015904
    Abstract: This invention provides novel reagents for the preparation of radiopharmaceuticals useful as imaging agents for the diagnosis of cardiovascular disorders, infection, inflammation and cancer, diagnostic kits comprising said reagents and intermediate compounds useful for the preparation of said reagents. The reagents are comprised of stable hydrazone modified biologically active molecules that react with gamma emitting radioisotopes to form radiopharmaceuticals that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: January 18, 2000
    Inventors: Michael Sworin, Milind Rajopadhye, Thomas David Harris, David Scott Edwards, Edward Hollister Cheesman, Shuang Liu
  • Patent number: 5885790
    Abstract: A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S). A preferred dye systems are based on the dye couple (MBTH-S) and 8-anilino-1-naphthalenesulfonate (ANS), and the dye couple MBTH-S and N-(3-sulfopropyl)analine. These dye indicator systems are used in conventional blood chemistry test strips and are particularly preferred for indication of glucose in blood.
    Type: Grant
    Filed: March 10, 1998
    Date of Patent: March 23, 1999
    Assignee: Mercury Diagnostics, Inc.
    Inventors: Joel S. Douglas, Karen R. Drexler
  • Patent number: 5808135
    Abstract: The present invention relates to novel substituted bicyclic 2-mesityl-cyclopentane-1,3-dione derivatives of the formula (I) ##STR1## in which A and Q together represent alkanediyl or alkenediyl, which is in each case optionally substituted by halogen, hydroxyl, mercapto or in each case optionally substituted alkyl, alkoxy, alkylthio, cycloalkyl, benzyloxy or aryl, and which furthermore optionally contains one of the following groups ##STR2## or is bridged by an alkanediyl group andB, B' and G have the meaning given in the description,process for their preparation and their use as agents for controlling pests, and herbicides.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: September 15, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Jacques Dumas, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Hans-Joachim Santel, Markus Dollinger, Andreas Turberg, Norbert Mencke
  • Patent number: 5776719
    Abstract: A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication system comprises 3-Methyl-6-(sodium sulfonate)-benzothiazolinone-(2)-hydrazone (MBTH-S). A preferred dye systems are based on the dye couple (MBTH-S) and 8-anilino-1-naphthalenesulfonate (ANS), and the dye couple MBTH-S and N-(3-sulfopropyl)analine. These dye indicator systems are used in conventional blood chemistry test strips and are particularly preferred for indication of glucose in blood.
    Type: Grant
    Filed: April 5, 1996
    Date of Patent: July 7, 1998
    Assignee: Mercury Diagnostics, Inc.
    Inventors: Joel S. Douglas, Karen R. Drexler
  • Patent number: 5405871
    Abstract: Compounds of the formula ##STR1## wherein each of o and p, independently of the other, is 0, 1, 2, 3, 4 or 5, the radicals R.sub.1 being the same or different when o is greater than 1 and the radicals R.sub.2 being the same or different when p is greater than 1;each of R.sub.1 and R.sub.2, independently of the other, is C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, halogen, --NO.sub.2, --OH, C.sub.1 -C.sub.4 alkoxy, halo-C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, halo-C.sub.1 -C.sub.4 alkylthio, --O--S(.dbd.O)--R.sub.6, --O--S(.dbd.O).sub.2 --R.sub.6, phenoxy or --N(R.sub.11)SO.sub.2 R.sub.12 and/or two substituents R.sub.1 and/or two substituents R.sub.2 are, independently of one another, together --Y--Z--Y--;R.sub.3 is hydrogen, C.sub.1 -C.sub.4 alkyl or halo-C.sub.1 -C.sub.4 alkyl;R.sub.4 is hydrogen, C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, unsubstituted phenyl or naphthyl or mono- or di-substituted phenyl or naphthyl;R.sub.5 is --S--R.sub.7, --S(.dbd.O)--R.sub.7, --S(.dbd.O).
    Type: Grant
    Filed: April 6, 1994
    Date of Patent: April 11, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Roger G. Hall, Alfons Pascual, Odd Kristiansen
  • Patent number: 5340837
    Abstract: Compounds of the formula ##STR1## wherein each of o and p, independently of the other, is 0, 1, 2, 3, 4 or 5, the radicals R.sub.1 being the same or different when o is greater than 1 and the radicals R.sub.2 being the same or different when p is greater than 1;each of R.sub.1 and R.sub.2, independently of the other, is C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, halogen, --NO.sub.2, --OH, C.sub.1 -C.sub.4 alkoxy, halo-C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, halo-C.sub.1 -C.sub.4 alkylthio, --O--S(.dbd.O)--R.sub.6, --O--S(.dbd.O).sub.2 --R.sub.6, phenoxy or --N(R.sub.11)SO.sub.2 R.sub.12 and/or two substituents R.sub.1 and/or two substituents R.sub.2 are, independently of one another, together --Y--Z--Y--;R.sub.3 is hydrogen, C.sub.1 -C.sub.4 alkyl or halo-C.sub.1 -C.sub.4 alkyl;R.sub.4 is hydrogen, C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, unsubstituted phenyl or naphthyl or mono- or di-substituted phenyl or naphthyl;R.sub.5 is --S--R.sub.7, --S(.dbd.O)--R.sub.7, --S(.dbd.O).
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: August 23, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Roger G. Hall, Alfons Pascual, Odd Kristiansen
  • Patent number: 5298658
    Abstract: A photographic element is detailed which provides for improved resolution by decreasing the blue and ultraviolet radiation typically associated with internal scatter and print-through. These and other improvements are provided in a photographic element comprising a support having thereon at least one hydrophilic colloid layer, and a radiation sensitive silver halide emulsion layer present as a portion of the colloid layer or in a separate layer wherein the emulsion contains a dye of the formula: ##STR1## wherein: A=counterion chosen from the set consisting of lithium, sodium, potassium, ammonium and alkylammonium andZ is a linking group.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: March 29, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Dietrich M. Fabricius
  • Patent number: 5258251
    Abstract: The present invention provides a hydrazone compound represented by the following general formula (1). This compound has higher hole mobility as compared with an electric charge transferring material such as the conventional hydrazone compound or the like. Accordingly, when this compound is contained in a photosensitive layer as the electric charge transferring material, there may be obtained an electrophotosensitive material excellent in sensitivity, charging ability and repeat characteristics. ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same as or different from one another, and each is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group.
    Type: Grant
    Filed: March 23, 1992
    Date of Patent: November 2, 1993
    Assignee: Mita Industrial Co., Ltd.
    Inventors: Yasuyuki Hanatani, Hiroaki Iwasaki
  • Patent number: 5215924
    Abstract: The invention relates to a method for determining an ion in an aqueous sample. The method involves contacting the sample with a water immiscible material including an ionophore, a pH indicator and a compound which stabilizes sensitivity of the assay. The ion reacts with the ionophore in the water immiscible material, releasing a proton which reacts with the pH indicator generating a color change which is representative of the ion to be measured. The stabilizing compound stabilizes this change. Also described are compositions including the three recited elements, and various new compounds useful as the stabilizer.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: June 1, 1993
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter Rittersdorf, Werner Guethlein, Detlef Thym, Peter Vogel
  • Patent number: 5208299
    Abstract: The present invention relates to nonlinear optical material comprising nonlinear optical dihydroxy arylhydrazones and to nonlinear optical materials comprising compositions containing at least one divalent moiety of nonlinear optical arylhydrazones. The present invention also relates to polyesters, polyestercarbonates, polycarbonates, polyethers, and poly(hydroxy ether) polymers, incorporating the dihydroxy arylhydrazone as recurring divalent moieties in the backbone of the polymer. The polymeric compositions of the present invention have high glass transition temperatures and exhibit stable nonlinear optical activity at high temperatures over a period of time.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: May 4, 1993
    Assignee: The Dow Chemical Company
    Inventors: Stephen E. Bales, David J. Brennan, Robert J. Gulotty, Anthony P. Haag, Muthiah N. Inbasekaran
  • Patent number: 5158600
    Abstract: Herbicidal 3-hydroxy-2-cyclohexen-1-ones of the formula ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen or methyl,R.sup.3 is C.sub.1-4 alkyl, cyclopropylmethyl, C.sub.3-4 alkenyl which may be substituted by one to three halogen atoms or C.sub.3-4 alkynyl,R.sup.4 is C.sub.1-4 alkyl,R.sup.5 each independently is halogen, C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkoxy, C.sub.1-4 alkylthio, C.sub.1-4 haloalkylthio or cyano,n is 0, 1 or 2, andm is 0, 1 or 2.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: October 27, 1992
    Assignee: Nihon Tokushu Noyaku Seizo K.K.
    Inventors: Toyohiko Kume, Toshio Goto, Atsumi Kamochi, Hidenori Hayakawa, Tadao Asami, Akihiko Yanagi
  • Patent number: 4743694
    Abstract: The addition of organolithium to dimethylhydrazones of certain ethers of a-hydroxyaldehydes results in the synthesis of threo- or erythro- intermediates readily convertible to threo- or erythro-2-amino alcohols.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: May 10, 1988
    Assignee: Mercek & Co., Inc.
    Inventor: David A. Claremon
  • Patent number: 4621156
    Abstract: Optical filter agents and photographic products and processes using same are disclosed. The optical filter agents are pH-sensitive hydrazone compounds conforming to the following structural formula: ##STR1## where R is any group which can provide a double bond for conjugation with the ##STR2## portion of the compound to provide light-absorbing capability or color for the agent at a pH above its pKa, X is a substituent of R providing at least one electron-withdrawing group and each R' can be defined as any substituent that does not impair the light-absorbing capacity of the compound at a pH above the pKa thereof. The pH-sensitive optical filter agents have a highly colored light-absorbing form at a pH above the pKa and are substantially non-absorbing at a pH below the pKa. The pH-sensitive optical filter agents are useful in photographic film units and processes for the protection of photoexposed photosensitive elements against the occurrence of fogging during in-light development.
    Type: Grant
    Filed: October 8, 1981
    Date of Patent: November 4, 1986
    Assignee: Polaroid Corporation
    Inventors: Derek H. R. Barton, Irena Y. Bronstein-Bonte, Lloyd D. Taylor
  • Patent number: 4606987
    Abstract: An electrophotographic photosensitive material has a photosensitive layer formed on an electroconductive substrate, with the photosensitive layer containing a polymeric binder and an organic photoconductor represented by the following formulaA--CH.dbd.CH).sub.n CH.dbd.NNHYwherein A is selected from the group consisting of an alkyl group having 1 to 12 carbon atoms, an aralkyl group having 7 to 14 carbon atoms, an aryl group having 6 to 20 carbon atoms and a heterocyclic residue of a 3- to 30- membered ring,wherein n is 1 or 2,Y is selected from the group consisting of --SO.sub.2 R', ##STR1## wherein R' is selected from the group consisting of an alkyl group having 1 to 12 carbon atoms, an aralkyl group having 7 to 14 carbon atoms, an aryl group having 6 to 20 carbon atoms and a heterocyclic residue of a 3- to 30- membered ring, and R.sup.2 and R.sup.3, R.sup.4 and R.sup.5, either form a ring together with the nitrogen atom to which R.sup.2 and R.sup.3, R.sup.4 and R.sup.5 are bonded and in this case R.sup.
    Type: Grant
    Filed: July 9, 1985
    Date of Patent: August 19, 1986
    Assignee: Toray Industries, Inc.
    Inventors: Kazuo Matsuura, Hiroki Osedo, Keisuke Ohshima
  • Patent number: 4593027
    Abstract: 3-Aryl-7-chloro-3,4-dihydroacridine-1,9(2H,10H)-dione 1-oximes and 1-hydrazone derivatives of the formula I ##STR1## and their physiologically tolerated acid addition and ammonium salts are described, as is a process for their preparation. The new compounds are chemotherapeutic agents and are active against protozoa, especially malaria plasmodia.
    Type: Grant
    Filed: October 11, 1983
    Date of Patent: June 3, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Erhardt Winklemann, Walter Durckheimer, Wolfgang Raether
  • Patent number: 4487957
    Abstract: A novel alkyl 4-methyl-3-formyl-penten-1-oate of the formula ##STR1## wherein R is alkyl of 1 to 5 carbon atoms and the dotted lines represent a double bond in the 3,4 or 4,5-position and their preparation and novel intermediates therefore and a novel process for the preparation of 4-methyl-3-formyl-pent-3-en-1-oic acid which is an intermediate for the preparation of compounds of the formula ##STR2## wherein R.sub.3 is selected from the group consisting of hydrogen and the residue of an alcohol R.sub.3 OH by the process of European Patent Application Ser. No. 0023849 published Feb. 11, 1981, which are used to prepare very active insecticidal esters.
    Type: Grant
    Filed: April 21, 1983
    Date of Patent: December 11, 1984
    Assignee: Roussel Uclaf
    Inventors: Jacques Martel, Jean Tessier, Jean-Pierre Demoute
  • Patent number: 4456769
    Abstract: A new one-step process for the preparation of hydrazidines of the general formula ##STR1## in which R represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group or an optionally substituted aralkyl group,or their acid addition salts, in high yield comprises reacting iminoalkyl ethers of the general formula ##STR2## in which R has the abovementioned meaning andR.sup.1 represents an optionally substituted alkyl group or an optionally substituted cycloalkyl group,or their acid addition salts, with hydrazine in solvents under reduced pressure and at temperatures between -80.degree. and +100.degree. C., the reaction being effected in the presence of water present in the solvent and/or in the hydrazine by employing it as hydrazine hydrate. The hydrazidines of formula (I) and their salts are valuable intermediates in heterocyclic chemistry, for example for the synthesis of herbicidally active as-triazinones.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: June 26, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Bonse, Thomas Schmidt
  • Patent number: 4438282
    Abstract: Sulfides prepared by reacting a sulfoxide with a hydrazine or hydroxylamine derivative or a quaternary salt thereof are useful starting materials for the preparation of drugs, pesticides and dyes.
    Type: Grant
    Filed: June 23, 1982
    Date of Patent: March 20, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Hartmut Lardon, Guenther Seybold