Hydroxy, Bonded Directly To Carbon, Or Ether Containing (h Of -oh May Be Replaced By A Substituted Or Unsubstituted Ammonium Ion Or A Group Ia Or Iia Light Metal) Patents (Class 564/292)
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Publication number: 20100191014Abstract: A fatty acid salt of an alkyl quaternary ammonium is used as a novel surfactant which is a cationic surfactant having high detergency and low foaming property.Type: ApplicationFiled: December 12, 2008Publication date: July 29, 2010Applicant: AISIN AW CO., LTDInventors: Toshiaki Iwase, Jun Kuroiwa, Masanori Yoshida, Katsuya Uenishi, Kouei Murayama
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Publication number: 20100183705Abstract: Phospholipid-analogous compounds of the general formula (I) in which A where R1 and R2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which can optionally be branched or/and substituted, where the total of the carbon atoms in the acyl and alkyl is 16 to 44 C atoms, s is an integer from 0 to 8, c is a radical of a primary or secondary alcohol of the formula RO—, where R is a saturated or unsaturated alkyl radical, mainly with cis double bond, of from 12 to 30 carbon atoms, n is an integer from 2 to 8, R3 a can be 1,2-dihydroxypropyl or b can be alkyl with 1 to 3 C atoms when z is >0 or c can be alkyl with 1 to 3 carbon atoms when n?2 and z=0, m is 1 or 2, x is an integer from 0 to 8, y is 1 for z=1 to S? or is 1 to 4 for z=1 z is an integer from 0 to 5, are novel and are suitable as liposome constituents, solubilizers and pharmaceuticals.Type: ApplicationFiled: September 28, 2009Publication date: July 22, 2010Applicant: Max-Planck-Gesellschaft zur Förderung du Wissenschaften e.V.Inventor: Hans-Jörg EIBL
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Patent number: 7750044Abstract: The present invention relates to a novel class of polymeric compounds having specific quaternized amine based upon a dimer acid reacted with an alkanolamine to make an ester quaternary compound. Dimer acid is a C-36 diacid having a cyclic structure and two amine groups that allow for the synthesis of a high molecular weight cationic compound which is extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of barrier products for personal care applications. These materials are dimethylaminopropyl amine free, which is highly desirable in personal care applications.Type: GrantFiled: April 1, 2008Date of Patent: July 6, 2010Assignee: SurfaTech CorporationInventors: Kevin A. O'Lenick, Anthony J. O'Lenick, Jr.
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Publication number: 20100160684Abstract: Alkylammonium halides of the formula are described wherein the alkylammonium halide is prepared by reacting an alkylamine hydrohalide salt and its corresponding free amine with at least two equivalents of an epihalohydrin.Type: ApplicationFiled: August 13, 2007Publication date: June 24, 2010Inventors: Joseph L. Deavenport, Rhonda C. Posey
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Publication number: 20100113763Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having <Chemistry Formula 11> and <Chemistry Formula 12>, respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.Type: ApplicationFiled: October 26, 2009Publication date: May 6, 2010Applicants: FUTURECHEM CO., LTD., THE ASAN FOUNDATIONInventors: Dae Hyuk MOON, Dae Yoon CHI, Dong Wook KIM, Seung Jun OH, Jin-sook RYU
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Publication number: 20090317908Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: ApplicationFiled: May 21, 2009Publication date: December 24, 2009Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Alberto Haces, Valentina Ciccarone
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Patent number: 7601872Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: January 21, 2005Date of Patent: October 13, 2009Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7598421Abstract: The invention provides a lipid of general formula (I) or (II): wherein X1, X2 and R1 to R5 are as defined herein. Such lipids are used to form complexes with a biologically-active material such as a nucleic acid, peptide or small molecule for delivering the biologically-active material to cells. The complexes may incorporate an integrin-binding peptide and, when the biologically-active material is DNA, thereby constitute a LID complex.Type: GrantFiled: November 8, 2004Date of Patent: October 6, 2009Assignee: UCL Biomedica PLCInventors: Helen C. Hailes, Alethea B. Tabor, John B. Wong, Michael Pilkington-Miksa, Stephen L. Hart, Christopher A. Hurley
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Patent number: 7541496Abstract: Compositions and methods for making compositions including a quaternary trialkylammonium halide compound are described. Compositions follow the formula: wherein the R1 groups are each individually selected from alkyl groups having from 1 to 12 carbon atoms; wherein the R2, R3, and R4 groups are each individually selected from hydrogen, hydroxide, alkyl groups having from 1 to 12 carbon atoms, and hydroxy alkyl groups having from 1 to 12 carbon atoms; wherein y ranges from 0 to 12; wherein X? is selected from fluoride, chloride, bromide, and iodide; wherein the quaternary trialkylammonium compound is present in an amount of at least 90 wt. percent; and wherein the composition comprises not greater than 4000 ppm of a trialkylamine or protonated form thereof.Type: GrantFiled: April 13, 2006Date of Patent: June 2, 2009Assignee: Dow Global Technologies Inc.Inventors: Joseph L. Deavenport, Rhonda C. Posey, David A. Wilson
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Patent number: 7531693Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.Type: GrantFiled: May 24, 2004Date of Patent: May 12, 2009Assignee: Molecular Transfer, Inc.Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
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Patent number: 7479573Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1—R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: January 21, 2005Date of Patent: January 20, 2009Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Publication number: 20090017057Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.Type: ApplicationFiled: March 17, 2008Publication date: January 15, 2009Applicant: PDS BIOTECHNOLOGY CORPORATIONInventors: Weihsu Chen, Weili Yan, Kenya Toney, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Patent number: 7470817Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)I, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: December 28, 2006Date of Patent: December 30, 2008Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Publication number: 20080317729Abstract: This invention relates to ammonium salts and stable storable ammonium salts and ammonium salt/mineral salt clathrate compounds (inclusion compounds, clusters) having acid dibasic anionic acid residues such as bicarbonate, to methods for producing them and to pharmaco-medical and chemical synthetic applications for said compounds.Type: ApplicationFiled: July 20, 2005Publication date: December 25, 2008Inventors: Helmut Kasch, Uwe Reuter, Ralf Oettmeier
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Patent number: 7411092Abstract: A quatemary ammonium salt of the following formula (1): {(R1)a(R2)b(R3)c(R4OCH2CH2OCH2CH2)dN}+.A???(1) [wherein, R1, R2 and R3 may be mutually the same or different and represent an alkyl group having 1 to 4 carbon atoms or analkyloxyethyl group of the formula (2): R5OCH2CH2—??(2) (wherein, R5 represents a methyl group or ethyl group), R4 represents a methyl group or ethyl group, and any two of R1, R2 and R3 may mutually bond at the end to form an alkylene chain, a, b and c represent an integer of 0 to 3, d represents an integer of 1 to 4, the sum of a, b and c is 3 or less, the sum of a, b, c and d is 4, and A? represents a bis(trifluoromethylsulfonyl)imidate ion [N(SO2CF3)2?], tetrafluoroborate ion (BF4?) or hexafluorophosphate ion (PF6?)].Type: GrantFiled: February 6, 2004Date of Patent: August 12, 2008Assignee: Koei Chemical Company, LimitedInventors: Nobuaki Honma, Yoshimi Yamada
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Publication number: 20080138626Abstract: Bactericidal substrates and methods of functionalizing the surface of substrates with quaternary ammonium and quaternary phosphonium groups using non-equilibrium RF plasmas are provided. The methods include the step of treating the surface of a substrate with a plasma to create surface active sites. Some methods include the step of reacting the surface active sites with linker molecules, which are then reacted with quaternary ammonium precursor molecules to provide a substrate surface functionalized with quaternary ammonium precursor groups. Other methods react the surface active sites with polymer precursor molecules under plasma conditions to form a covalently-bound polymer layer having reactive sites. The polymer reactive sites are reacted with quaternary phosphonium precursor molecules to provide a substrate surface functionalized with quaternary phosphonium groups. Also provided are bactericidal substrates having immobilized, covalently-bound quaternary ammonium or quaternary phosphonium groups.Type: ApplicationFiled: December 11, 2006Publication date: June 12, 2008Inventors: Ferencz S. Denes, Sorin Odisei Manolache, Luis Emilio Cruz-Barba, Alvaro de Jesus Martinez-Gomez
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Patent number: 7323594Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by -X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: December 28, 2006Date of Patent: January 29, 2008Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7300545Abstract: A water-soluble polymer dispersion, process for producing the same and a method of use therefor. In particular, the water-soluble polymer dispersion is one comprising water-soluble polymer fine particles of 100 ?m or less diameter having at least one ionic property selected from among cationic, amphoteric, nonionic and anionic properties together with a polyalkyleneimine and/or a product of polyalkyleneimine modification wherein according to necessity an appropriate amount of water-soluble inorganic salt is incorporated. The provided process enables easily performing the production in dispersed form by means of production facilities of low cost. The obtained water-soluble polymer dispersion is excellent in storage stability and exhibits satisfactory fluidity and solubility so as to enable use in papermaking raw material pretreatments added to papermaking raw materials prior to machine operation and also for enhancement of freeness, increase of sizing degree and enhancement of yield.Type: GrantFiled: February 25, 2003Date of Patent: November 27, 2007Assignee: Hymo CorporationInventors: Takumi Ohara, Emiko Odaka, Ryousuke Yonemoto
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Patent number: 7297289Abstract: Electrical storage devices having excellent low-temperature properties can be obtained by using a quaternary salt (or ionic liquid) of general formula (1) below as an electrolyte salt for electrical storage devices or a liquid electrolyte for electrical storage devices. In formula (1), R1 to R4 are each independently an alkyl group of 1 to 5 carbons or an alkoxyalkyl group of the formula R?—O—(CH2)n—, with the proviso that at least one group from among R1 to R4 is the above alkoxyalkyl group. X is a nitrogen or phosphorus atom, and Y is a monovalent anion.Type: GrantFiled: March 25, 2002Date of Patent: November 20, 2007Assignee: Nisshinbo Industries, Inc.Inventors: Takaya Sato, Gen Masuda, Ryutaro Nozu, Tatsuya Maruo
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Patent number: 7166745Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)1, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —CH2)p—D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: November 12, 1999Date of Patent: January 23, 2007Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7145039Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: January 21, 2005Date of Patent: December 5, 2006Assignee: Invitrogen Corp.Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7105574Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.Type: GrantFiled: March 24, 2000Date of Patent: September 12, 2006Assignee: Vical IncorporatedInventor: Carl J. Wheeler
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Patent number: 7030275Abstract: Monomer compounds comprising several cationic groups, a process for making such compounds and polymers derived from such compounds are provided.Type: GrantFiled: June 3, 2003Date of Patent: April 18, 2006Assignee: Rhodia Inc.Inventor: Leo Zhaoqing Liu
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Patent number: 7026512Abstract: The present invention relates to novel tertiary alkanolamines useful as catalysts for preparing polyurethane foams and as additives to reduce the dynamic surface tension of aqueous solutions. The tertiary alkanolamines may be represented by formula (I): wherein A, R1–R6, and n are defined herein, and where the tertiary alkanolamine is acid-blocked with a carboxylic acid.Type: GrantFiled: December 10, 2003Date of Patent: April 11, 2006Assignee: Air Products and Chemicals, Inc.Inventors: William R. Raymond, Juan Jesus Burdeniuc, Khalil Yacoub
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Patent number: 6900313Abstract: The invention relates to chiral ionic liquids of the general formula [A]n+[Y]n?, whereby n=1 or 2, the anion [Y]n? is the anion of an organic or inorganic proton acid and the cation [A]+ an optically active organic ammonium cation with up to 50 carbon atoms, at least one chirality center and at least one functional group that can produce a coordination by forming hydrogen bridges or by providing free electron pairs. At least one chirality center is provided with a distance of up to 5 atomic bonds from the functional group. The invention also relates to a method for producing said chiral ionic liquids and to the use thereof in methods for the asymmetric synthesis, the asymmetric catalysis and for separating racemates.Type: GrantFiled: January 29, 2001Date of Patent: May 31, 2005Inventors: Peter Wasserscheid, Wilhelm Keim, Carsten Bolm, Andreas Bösmann
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Patent number: 6869977Abstract: The present invention discloses a series of quaternary nitrogen compounds in which the four groups surrounding nitrogen are (a) one glyceryl portion, (b) two methyl groups and (c) a hydroxy ethyl group. The compound of the present invention is an outstanding moisturizer when applied to skin.Type: GrantFiled: April 9, 2004Date of Patent: March 22, 2005Assignee: Colonial Chemical Inc.Inventors: Anthony J. O'Lenick, Jr., Dean A. Smith
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Publication number: 20040199015Abstract: The water present within an ionic liquid that is in a liquid state at 25° C. or an organic solution containing at least one ionic compound is decomposed by bringing electrodes into contact with the ionic liquid or organic solution within an atmosphere having a dew-point temperature not higher than −40° C. or under a reduced pressure of not more than 75 torr, thereby reducing the water content. This process makes it possible to obtain highly dehydrated ionic liquids.Type: ApplicationFiled: January 22, 2004Publication date: October 7, 2004Inventors: Kanako Yuyama, Ryutaro Nozu, Gen Masuda, Takaya Sato
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Patent number: 6765102Abstract: Water-soluble or water-dispersible branched or unbranched cationic epoxy compounds comprise a backbone having covalently attached thereto two or more epoxy moieties and one or more of the same or different organoonium moieties. The backbone comprises at least 25 weight % oxygen.Type: GrantFiled: July 29, 2002Date of Patent: July 20, 2004Assignee: Eastman Kodak CompanyInventors: Jeffrey W. Leon, Paul R. West, Robert E. Mccovick
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Publication number: 20040106532Abstract: It is disclosed a cleaning liquid for stripping and dissolving a photoresist pattern having a film thickness of 10-150 &mgr;m, which contains (a) 0.5-15 mass % of a quaternary ammonium hydroxide, such as tetrapropylammonium hydroxide and tetrabutylammonium hydroxide, (b) 65-97 mass % of a water-soluble organic solvent, such as dimethylsulfoxide or a mixed solvent thereof with N-methyl-2-pyrrolidone, sulforane, etc. and (c) 0.5-30 mass % of water, and a method for treating a substrate therewith.Type: ApplicationFiled: October 9, 2003Publication date: June 3, 2004Inventors: Shigeru Yokoi, Kazumasa Wakiya, Koji Saito
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Publication number: 20040094741Abstract: Electrical storage devices having excellent low-temperature properties can be obtained by using a quaternary salt (or ionic liquid) of general formula (1) below as an electrolyte salt for electrical storage devices or a liquid electrolyte for electrical storage devices.Type: ApplicationFiled: September 25, 2003Publication date: May 20, 2004Inventors: Takaya Sato, Gen Masuda, Ryutaro Nozu, Tatsuya Maruo
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Patent number: 6727387Abstract: A compound of formula I:Type: GrantFiled: May 6, 2002Date of Patent: April 27, 2004Assignee: Rohm and Haas CompanyInventors: Ravindranath Mukkamala, Rajiv Monohar Banavali
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Patent number: 6716882Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: GrantFiled: April 23, 2002Date of Patent: April 6, 2004Assignee: Invitrogen CorporationInventors: Alberto Haces, Valentina C. Ciccarone
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Patent number: 6656936Abstract: Acylcarnitine analogues having alkyl side chains of 10 to 30 carbon atoms display excellent spermicidal and anti-HIV activity, a well as being potent inhibitors of the growth of Candida albicans.Type: GrantFiled: July 5, 2002Date of Patent: December 2, 2003Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Prashant S. Savle, Richard D. Gandour, Gustavo F. Doncel
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Publication number: 20030134423Abstract: Lipids and compositions of lipids that can be used as lipid aggregates (i.e., liposomes) for the delivery of macromolecules and other compounds into cells are provided.Type: ApplicationFiled: January 4, 2002Publication date: July 17, 2003Inventors: Yong Liang Chu, Frank Q. Li, Jian-Tai Qiu, Jerry Lin
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Patent number: 6576684Abstract: Disclosed are compositions from which radically initiated oligomers/polymers having a controlled molecular weight, low polydispersity and a vinyl or dienyl end group are prepared. Further subjects of the invention are a process for controlled radical polymerization, oligomers/polymers obtainable by said process and the use of specific addition fragmentation agents for the polymerization process. The addition fragmentation agents are new in part and these are also subject of the present invention. The addition fragmentation agents are of the formula (Ia), (Ib) or (Ic) where Y is a group which activates the double bond towards Michael addition.Type: GrantFiled: February 15, 2001Date of Patent: June 10, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Vincent Desobry, Peter Murer, Anne Schuwey
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Patent number: 6576794Abstract: A process for producing an ether amine (3), which comprises reacting a primary or secondary alcohol (1), ROH, with acrylonitrile in an amount of 0.8 to 1.2 equivalents of the alcohol (1) in the presence of an alkali metal hydroxide in an amount of not less than 0.01 part by weight, but less than 0.05 part by weight per 100 parts by weight of the alcohol (1) to obtain an alkyloxypropionitrile (2), and then adding water to the reaction system without removing the alkali metal hydroxide therefrom and effecting hydrogenation using a hydrogenation catalyst: ROH(1)+CH2=CHCN→ROCH2CH2CN(2)→ROCH2CH2CH2NH2(3) wherein R denotes a linear or branched alkyl or alkenyl group having 6 to 24 carbon atoms.Type: GrantFiled: December 17, 2001Date of Patent: June 10, 2003Assignee: Kao CorporationInventors: Tetsuaki Fukushima, Hiroyuki Masuda, Uichiro Nishimoto, Hiroshi Abe
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Patent number: 6573405Abstract: An ionic liquid having a melting point of no more than 60° C., formed by the reaction of a quaternary ammonium compound of the formula: R1R2R3R4N+X− (I) or a mixture of two or more therof; with a halide of zinc, tin or iron, or a mixture of two or more thereof.Type: GrantFiled: September 24, 2001Date of Patent: June 3, 2003Assignee: Scionix LimitedInventors: Andrew P. Abbott, David L. Davies
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Patent number: 6541649Abstract: The present invention provides processes for the synthesis of novel cationic amphiphiles capable of facilitating transport of biologically active molecules into cells wherein the said amphiphiles contain N-hydroxyalkyl group and have at least one hydroxyalkyl group containing 1-3 carbon atoms directly linked to the positively charged nitrogen atom.Type: GrantFiled: December 4, 2001Date of Patent: April 1, 2003Assignee: Council of Scientific & Industrial ResearchInventors: Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao, Arabinda Chaudhuri
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Patent number: 6538032Abstract: The present invention relates to an antitumor agent containing a phytosphingosine derivative, and more specifically, to an antitumor agent containing a phytosphingosine derivative of formula I as an active ingredient, wherein R1, R2 and R3 respectively represents a hydrogen atom or a C1-C8 alkyl group; and X represents an atom or an atomic group containing a halogen atom, a hydroxyl group, an alkyl sulfonate group or an aryl sulfonate group.Type: GrantFiled: September 7, 2001Date of Patent: March 25, 2003Assignee: Charmzone Co., Ltd.Inventors: Sung Keon Namgoong, Seon Yi Park
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Publication number: 20030036665Abstract: Novel quaternary ammonium compounds are disclosed, as well as methods for their preparation and their use in the treatment of hair, fibers and textiles as softening and conditioning agents. The high substantivity of these novel quaternary ammonium compounds to hair, fibers, and textiles, and their mildness to the skin and eyes, make them well suited for softening and conditioning fibers for applications such as personal care, laundry, and textile use.Type: ApplicationFiled: June 20, 2002Publication date: February 20, 2003Applicant: FINETEX, INC.Inventors: Ismail I. Walele, Samad A. Syed
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Publication number: 20030013769Abstract: A compound of formula I: 1Type: ApplicationFiled: May 6, 2002Publication date: January 16, 2003Inventors: Ravindranath Mukkamala, Rajiv Manohar Banavali
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Patent number: 6503945Abstract: The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating transport of biologically active molecules into cells.Type: GrantFiled: January 11, 2002Date of Patent: January 7, 2003Assignee: Council of Scientific & Industrial ResearchInventors: Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao, Arabinda Chaudhuri
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Patent number: 6465419Abstract: Esters derived from alkanolamines, dicarboxylic acids and fatty alcohols and the cationic surfactants obtainable therefrom. Novel alkanolamine esters based on the esterification reaction of alkanolarnines, optionally alkoxylated, dicarboxylic acids and fatty alcohols, optionally alkoxylated, as well as the cationic surfactants and esterquats obtainable therefrom, are described. The cationic surfactants and esterquats thus obtained exhibit a high degree of efficacy in softening and conditioning natural and synthetic fibres such as textiles, paper and hair, and are therefore usable in treatments for softening and conditioning the said fibres. Novel aqueous fabric-softening compositions which contain the cationic surfactants and esterquats mentioned, optionally in combination with other active softening substances, are also described.Type: GrantFiled: June 7, 2001Date of Patent: October 15, 2002Assignee: Kao CorporationInventors: María José Bermejo Osés, Josep Ferrer Vilaret, Marisa Tomás Mumbrú
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Patent number: 6452030Abstract: This invention provides a hydroxyl group-containing betaine compound and a long-chain alkyl group-containing betaine compound, both of which are highly biodegradable and useful as surfactants, bactericides, antistatic agents, softening agents, rust inhibitors, resin modifiers, synthetic intermediates, etc. The invention further provides processes for producing such betaine compounds.Type: GrantFiled: November 17, 2000Date of Patent: September 17, 2002Assignee: Nippon Shokubai Co., Ltd.Inventors: Junichi Chosa, Takashi Tomita, Malcolm Andrew Kelland
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Patent number: 6444852Abstract: A novel amine is provided with improved water dispersibility which is useful to modify the formation of hydrates in streams containing low-boiling hydrocarbons and water.Type: GrantFiled: June 21, 2000Date of Patent: September 3, 2002Assignee: Goldschmidt Chemical CorporationInventors: Charles R. Milburn, Gary M. Sitz
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Patent number: 6437185Abstract: Novel quaternary ammonium compounds are disclosed, as well as methods for their preparation and their use in the treatment of hair, fibers and textiles as softening and conditioning agents. The high substantivity of these novel quaternary ammonium compounds to hair, fibers, and textiles, and their mildness to the skin and eyes, make them well suited for softening and conditioning fibers for applications such as personal care, laundry, and textile use. For example, quaternary ammonium compounds such as N′,N″,N′″-Triethyl, N′,N′,N′″, N′″-Tetramethyl, N″-[(Polyoxypropyi)-&ohgr;-hydroxyalkyl], dipropylene triammonium triethosulfate have been prepared. Quaternary ammonium compounds may also include those involving other reactive groups known to those skilled in the art.Type: GrantFiled: June 13, 2000Date of Patent: August 20, 2002Assignee: Finetex, Inc.Inventors: Ismail I. Walele, Samad A. Syed
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Patent number: 6414191Abstract: The present invention relates to a process for the continuous preparation of methoxyamine hydrochloride by cleavage of acetone oxime methyl ether by means of hydrogen chloride and water, wherein the cleavage is carried out in a reaction column having less than 20 theoretical plates and the amount taken off at the top is set to at least 30% of the amount of feed.Type: GrantFiled: September 11, 2001Date of Patent: July 2, 2002Assignee: BASF AktiengesellschaftInventors: Frank Heimann, Werner Peschel, Bernd Bartenbach, Horst Hartmann, Michael Keil, Josef Wahl
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Patent number: 6414170Abstract: The present invention relates to a method for preparing a cationic surfactant in which physical chemical characteristics such as softness, antistatic properties, etc. as well as biodegradability are quite excellent due to having an ester group and a hydrophilic hydroxyl group in its molecules. A cationic surfactant of the present invention is prepared by reacting tertiary amine drivatives, fatty acid, and epihalohydrin, and prepared simply by reacting esterification and quaternary reactions in one step with a high yield. The above cationic surfactant is a high grade alkyl quaternary ammonium compound as represented in General Formula (1), wherein R1 is a C1-C4 alkyl group; R2 is a C7-C21 linear or branched alkyl or alkenyl group; A is OCOR3, NHCOR3 or OH; R3 is a C7-C21 linear or branched alkyl or alkenyl group; X is a halogen atom; and n is an integral number from 2 to 6.Type: GrantFiled: January 23, 2001Date of Patent: July 2, 2002Assignee: LG Chemical Ltd.Inventors: Dong-Il Kim, Jeong-Wook Ha, Tae-Seong Kim, Moon-Jeong Rang
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Publication number: 20020077366Abstract: The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating transport of biologically active molecules into cells.Type: ApplicationFiled: January 11, 2002Publication date: June 20, 2002Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao, Arabinda Chaudhuri
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Patent number: 6399663Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: GrantFiled: August 25, 2000Date of Patent: June 4, 2002Assignee: Invitrogen CorporationInventors: Alberto Haces, Valentina C. Ciccarone