Processes Patents (Class 564/318)
  • COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES
    Publication number: 20110269808
    Abstract: The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanok novel process intermediates and methods for making the novel process intermediates.
    Type: Application
    Filed: July 11, 2011
    Publication date: November 3, 2011
    Applicants: ASTEX THERAPEUTICS LIMITED, CANCER RESEARCH TECHNOLOGY LIMITED, THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
    Inventors: Steven John WOODHEAD, David Charles REES, Martyn FREDERICKSON, Kyla Merriom GRIMSHAW
  • Phenyl propenone compounds
    Publication number: 20030204114
    Abstract: The invention relates to a process for the enantioselective preparation of tolterodiine and analogues and salts thereof comprises the steps of:
    Type: Application
    Filed: March 28, 2003
    Publication date: October 30, 2003
    Inventors: Pher G. Andersson, Christian Hedberg
  • Asymmetric hydrogenation method of a ketonic compound and derivative
    Patent number: 6166257
    Abstract: The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative.The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: December 26, 2000
    Assignee: Rhodia Chimie
    Inventors: Francois Mathey, Frederic Robin, Francois Mercier, Michel Spagnol
  • Process for the preparation of optically active methadones in high enantiomeric purity
    Patent number: 6143933
    Abstract: A method of preparing optically active methadones comprises an enzymatic process for the resolution of 1-dialkyl-amino-2-propanol and conversion of the enantiomers to the optically active methadones in high enantiomeric purity.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: November 7, 2000
    Assignee: Salford Ultrafine Chemicals & Research Ltd.
    Inventors: Feodor Scheinmann, Jonathan David Hull, Nicholas John Turner
  • 5H-dibenzo(A,D) cycloheptanylidene derivative and 5H-dibenzo (A,D) cycloheptenylidene derivative, and electrophotographic photosensitive member using the same
    Patent number: 5024912
    Abstract: A 5H-dibenzo [a,d] cycloheptenylidene derivative and a 5H-dibenzo [1,d] cycloheptenylidene derivative represented by the following general formula [I]: ##STR1## wherein X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--; R.sub.1 and R.sub.2 are alkyl groups, aralkyl groups, aromatic groups or heterocyclic groups, R.sub.3 and R.sub.4 are hydrogen atoms, alkyl groups, alkoxy groups or halogen atoms; and Ar.sub.1 is an aromatic group or a heterocyclic group, process for producing those derivatives, and electrophotographic photosensitive member using the same.
    Type: Grant
    Filed: May 10, 1989
    Date of Patent: June 18, 1991
    Assignee: Canon Kabushiki Kaisha
    Inventors: Toshie Neishi, Toshihiro Kikuchi, Takao Takiguchi, Koichi Suzuki, Masakazu Matsumoto
  • Coordination complexes of platinum with amides
    Patent number: 4855498
    Abstract: Disclosed are platinum (IV) chelates derived from substituted amides. The chelates result from the reaction under mild conditions of potassium chloroplatinate (II) and the appropriate amide. The chelate transdichloro-cis-bis(dimethylacetamide-C,O) was prepared, fully characterized and exemplified in preparation of the antihistamine diphenhydramine hydrochloride.
    Type: Grant
    Filed: February 22, 1988
    Date of Patent: August 8, 1989
    Assignee: University of Delaware
    Inventors: Rosette M. Roat, Seymour Yolles