Nitrogen Bonded Directly To The Aryl Ring Or Ring System Patents (Class 564/350)
  • Patent number: 8039673
    Abstract: Described are antioxidant macromolecules and methods of making and using same.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: October 18, 2011
    Assignee: Polnox Corporation
    Inventors: Ashok L. Cholli, Rajesh Kumar
  • Patent number: 7030160
    Abstract: The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: April 18, 2006
    Assignee: Sanofi-Aventis
    Inventors: Laura Barzaghi, Philippe R. Bovy, Roberto Cecchi, Tiziano Croci, Stefano Romagnano
  • Patent number: 6908493
    Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R1 and R2 are each individually selected from a hydrogen atom, a C1 to C3 alkyl group, a C1 to C5 mono or dihydroxyalkyl group; phenyl or benzyl optionally substituted with an alkoxy group, or R1 and R2 together with the nitrogen atom to which they are attached form a piperazine, piperidine, imidazole, or morpholine ring.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: June 21, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Mu-Ill Lim, Yuh-Guo Pan, James S. Anderson
  • Patent number: 6765093
    Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R1 and R2 are each individually selected from a hydrogen atom, a C1 to C3 alkyl group, a C1 to C5 mono or dihydroxyalkyl group; phenyl or benzyl optionally substituted with an alkoxy group, or R1 and R2 together with the nitrogen atom to which they are attached form a piperazine, piperidine, imidazole, or morpholine ring.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: July 20, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Mu-Ill Lim, Yuh-Guo Pan, James S. Anderson
  • Patent number: 6521667
    Abstract: The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: February 18, 2003
    Assignees: NPS Pharmaceuticals, Inc., SmithKline Beecham, PLC, SmithKline Beecham, Corp.
    Inventors: Eric G. Del Mar, Robert M. Barmore, Derek Sheehan, Bradford C. Van Wagenen, James F. Callahan, Richard M. Keenan, Nikesh R. Kotecha, Maria Amparo Lago, Linda Sue Southall, Mervyn Thompson
  • Patent number: 6022894
    Abstract: The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: February 8, 2000
    Assignees: NPS Pharmaceuticals, Inc., SmithKline Beecham, Corp., SmithKline Beecham, PLC
    Inventors: Eric G. Del Mar, Robert M. Barmore, Derek Sheehan, Bradford C. Van Wagenen, James F. Callahan, Richard M. Keenan, Nikesh R. Kotecha, Maria Amparo Lago, Linda Sue Southall, Mervyn Thompson
  • Patent number: 5723489
    Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1.These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity, gastrointestinal diseases and achalasia.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: March 3, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Philip M. Sher, William N. Washburn, Kathleen M. Poss
  • Patent number: 5684202
    Abstract: The present invention relates to novel tertiary amines derived from bisphenoles, diepoxides and aromatic secondary amines, to a process for their preparation and to their use as hardening accelerators for ethylenically unsaturated cold hardenable acrylic and polyester resins.
    Type: Grant
    Filed: September 5, 1995
    Date of Patent: November 4, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Helmut-Martin Meier, Wolfgang Fischer, Horst Clemens
  • Patent number: 5430063
    Abstract: The invention concerns a phenoxyphenyl compound having the formula ##STR1## wherein R is one or two halogen atoms; andA is CH.sub.2 NR.sub.1 R.sub.2 or 4,5-dihydro-1H-imidazole, in which R.sub.1 and R.sub.2 are independently selected from hydrogen and lower alkyl; ora pharmaceutically acceptable salt thereof.The compounds have long half-lives and can be used against depression.
    Type: Grant
    Filed: February 3, 1993
    Date of Patent: July 4, 1995
    Assignee: Akzo N.V.
    Inventors: Gerardus S. F. Ruigt, Dirk Leysen, Johannes H. Wieringa
  • Patent number: 5047425
    Abstract: Compounds of the formula ##STR1## wherein Ar, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and n have the meanings mentioned in the description, processes and intermediates for their preparation, pharmaceutical compositions which contain them and their use in therapy in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: September 10, 1991
    Assignee: Simes Societa Italiana Medicinali & Sintetici SpA
    Inventors: Cesare Casagrande, Francesco Santangelo, Luisa Calabi
  • Patent number: 4652584
    Abstract: Phenoxypropanol derivatives having a 2-acetylenic moiety on the phenyl group thereof of the following formula (I): ##STR1## and their use as anti-hypertensives, e.g. in man. Also part of the invention are pharmaceutical compositions and intermediates used in the synthesis.
    Type: Grant
    Filed: July 13, 1984
    Date of Patent: March 24, 1987
    Assignee: McNeilab, Inc.
    Inventor: John R. Carson
  • Patent number: 4376125
    Abstract: 1-(p-Amino-.alpha.,.alpha.-dimethylphenethylamino)-3-(1-naphthoxy)-2-propan ol, 1-(p-hydroxy-.alpha.,.alpha.-dimethylphenethylamino)-3-(1-naphthoxy)-2-pro panol, 1-(p-methyl-.alpha.,.alpha.-dimethylphenethylamino)-3-(1-naphthoxy)-2-prop anol, 1-(p-methoxy-.alpha.,.alpha.-dimethylphenethylamino)-3-(1-naphthoxy)-2-pro panol and the pharmaceutically acceptable acid addition salts thereof are effective, long lasting .beta.-adrenergic blocking agents and areas of indication are hypertension, angina pectoris, cardiac arrythmia, and the like.
    Type: Grant
    Filed: November 5, 1980
    Date of Patent: March 8, 1983
    Assignee: University of Virginia Alumni Patents Foundation
    Inventors: Gary Brooker, Wesley L. Terasaki, Joel M. Linden
  • Patent number: 4371545
    Abstract: The present invention relates to new isopropyl amine compounds and processes for preparing the same. This invention also relates to pharmaceutical compositions containing said isopropyl amine compounds.The new isopropyl amine compounds correspond to the following general formula: ##STR1## wherein R represents a nitrophenyl radical, which may be substituted one or more times by halogen, preferably chloride, and/or by lower straignt- or branched-chain alkyl radicals containing from 1 to 4 carbon atoms an/or by alkoxy radicals containing from 1 to 3 carbon atoms and salts thereof with physiologically compatible acids.
    Type: Grant
    Filed: March 17, 1981
    Date of Patent: February 1, 1983
    Assignee: Dolorgiet Beteiligungs GmbH
    Inventors: Wilhelm Kunz, Klaus Gruber
  • Patent number: 4356322
    Abstract: A series of novel derivatives of phenoxyalkanolamine of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen, alkyl of 1 to 2 carbon atoms, methoxy, halogen, nitro, amino or acylamino residues, and the salts thereof, are described, as are methods for their synthesis. The compounds are highly active .beta..sub.1 -specific sympathicomimetics with a partially antagonistic component.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: October 26, 1982
    Assignee: Veb Arzneimittelwerk Dresden
    Inventors: Dieter Lehmann, Klaus Femmer, Gottfried Faust
  • Patent number: 4348505
    Abstract: A liquid adduct is prepared from the reaction of an amine, a polyepoxide compound with a functionality greater than 2, and, optionally, a diglycidyl ether of bisphenol A and/or the hydrogenated equivalent thereof, an accelerator or a suitable solvent; said reaction continuing until no active epoxy groups are available. The adducts are useful as curing agents for epoxy resins in both room temperature and heat cured applications to produce protective coatings of superior properties.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: September 7, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Marianne Di Benedetto, John A. Gannon
  • Patent number: 4336267
    Abstract: This invention relates to novel compounds of the general formula ##STR1## Representative compounds within the scope of the invention are ##STR2## The compounds are disclosed as being useful for treating symptoms and signs of cardiac failure by stimulating the .beta.-receptors of the heart. Methods of treatment using these compounds are discussed.
    Type: Grant
    Filed: May 19, 1980
    Date of Patent: June 22, 1982
    Assignee: Aktiebolaget Hassle
    Inventors: Enar I. Carlsson, Nils H. A. Persson, Gustav B. R. Samuelsson, Kjell I. L. Wetterlin