Halogen, Bonded Directly To Carbon, Containing Patents (Class 564/442)
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Patent number: 7446226Abstract: The invention relates to new compounds, namely capsaicin derivates, a new method for their production, and their use as micro-organism-repellent agents in paints and coatings, in particular for marine installations and ships, but also for land-based structures.Type: GrantFiled: September 10, 2004Date of Patent: November 4, 2008Assignee: aXimed ASInventors: Torsten Helsing, Einar Bakstad
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Publication number: 20080268071Abstract: Disclosed herein are substituted cyclohexanone-based NMDA receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: April 25, 2008Publication date: October 30, 2008Applicant: AUSPEX PHARMACEUTICALS, INC.Inventors: Thomas G. Gant, Sepehr Sarshar
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Patent number: 7439400Abstract: The invention disclosed a new process of asymmetric alkynylation of ketone or ketimine, involving the chiral ligand-mediated asymmetric addition of zinc or copper acetylide to a trifluoromethyl ketone or ketimine intermediate to give a chiral tertiary proparglic alcohols or amines. The adduct compounds include the key precursors to the potent HIV reverse transcriptase inhibitor Efavirenz (DMP 266), DPC 961 and DPC 083. The invention also disclosed a novel chiral amino alcohol ligand.Type: GrantFiled: June 16, 2003Date of Patent: October 21, 2008Assignee: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Biao Jiang, Yugui Si
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Publication number: 20080221176Abstract: This invention relates to compounds that are modulators of the liver X receptors (LXRs), and also to the methods for the making and use of such compounds.Type: ApplicationFiled: August 23, 2006Publication date: September 11, 2008Inventors: John Loren Collins, Eugene Lee Stewart, William Zuercher, Esther Chao, Robert Wiethe, Justin Caravella
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Publication number: 20080166299Abstract: The invention relates to radiolabeled compounds and their use in methods of imaging amyloid deposits, as well as to methods of their manufacture. The invention also relates to compounds for inhibiting the aggregation of amyloid proteins that form amyloid deposits, methods for delivering therapeutic agents to amyloid deposits, as well as methods of making compounds that inhibit the aggregation of amyloid proteins.Type: ApplicationFiled: December 6, 2007Publication date: July 10, 2008Applicant: Trustees of The University of PennsylvaniaInventors: Hank F. Kung, Mei Ping Kung
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Publication number: 20080132559Abstract: This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3? kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.Type: ApplicationFiled: October 1, 2007Publication date: June 5, 2008Applicant: NEURIM PHARMACEUTICALS (1991) LTD.Inventors: Tal Peleg-Shulman, Moshe Laudon, Dorah Daily
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Patent number: 7365085Abstract: Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.Type: GrantFiled: March 26, 2003Date of Patent: April 29, 2008Assignee: SmithKline Beecham CorporationInventors: Ajita Bhat, John Jeffrey McAtee, Scott K. Thompson, James S. Frazee, Lara S. Kallander, Chun Ma, Joseph Marino, Michael J. Neeb, Robert A. Stavenger
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Patent number: 7176334Abstract: A process for the preparation of substituted halogenated anilines from substituted halogenated 1-chlorobenzenes which comprises a) reacting a substituted halogenated 1-chlorobenzene selectively with an imine in the presence of a transition metal catalyst complex and a base to form an N-aryl imine; b) hydrolyzing the N-aryl imine; and c) isolating the substituted halogenated aniline.Type: GrantFiled: December 16, 2003Date of Patent: February 13, 2007Assignee: BASF AktiengesellschaftInventors: Jonathan O. Smith, Melissa A. Petruska, Jon J. Longlet
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Patent number: 7087778Abstract: Processes for producing antibacterial agents and intermediates useful in producing antibacterial agents are provided and include producing compound (VI-a) in accordance with the following reaction schema, as well as production intermediates thereofType: GrantFiled: August 23, 2004Date of Patent: August 8, 2006Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Kouji Sato, Yoshihiro Takayanagi, Katsuhiko Okano, Keiji Nakayama, Akihiro Imura, Mikihiro Itoh, Tsutomu Yagi, Yukinari Kobayashi, Tomoyuki Nagai
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Patent number: 7053123Abstract: (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1–C6 alkoxy, nitro, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2–C6 alkoxy); and R2 and R3 are independently selected from the group consisting of halogen, C1–C6 alkoxy, C1–C6 alkyl, nitro, cyano, hydroxyl, phosphonato, amino, sulfamyl, carboxy, acetoxy, and dimethylamino (C2–C6 alkoxy); provided: R1 may not be halogen when R2 and R3 are both halogen; R2 may not be 2-halogen when R3 is 4-halogen; or a pharmaceutically acceptable salt thereof; or formula II: wherein: R4 is selected from the group consisting of C1–C6 alkoxy, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2–C6 alkoxy); R6 is selected from the group consisting of nitro, hydrogen, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2–C6 alkoxy); and R7 is selected from the group consistinType: GrantFiled: October 5, 2001Date of Patent: May 30, 2006Assignee: Temple University-of the Commonwealth System of Higher EducationInventors: E. Premkumar Reddy, M. V. Ramana Reddy
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Patent number: 7045660Abstract: This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. The present invention is therefore directed to their pharmacological use for inhibiting TNF and/or cyclic AMP phosphodiesterase, pharmacological compositions comprising the compounds and methods for their preparation.Type: GrantFiled: March 3, 2004Date of Patent: May 16, 2006Assignee: Aventis Pharma LimitedInventors: Garry Fenton, Tahir Nadeem Majid, Malcolm Norman Palfreyman
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Patent number: 7041852Abstract: The present invention relates to a process for preparing perfluoroalkylanilines and to their use for preparing active ingredients, in particular for agrochemicals.Type: GrantFiled: November 6, 2003Date of Patent: May 9, 2006Assignee: Bayer Chemicals AGInventors: Albrecht Marhold, Axel Pleschke
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Patent number: 6900245Abstract: The present invention relates to a pharmaceutical composition for treating or preventing obesity, comprising novel crystalline sibutramine methanesulfonate hemihydrate of formula (I).Type: GrantFiled: October 3, 2003Date of Patent: May 31, 2005Assignee: Hanmi Pharm. Co., Ltd.Inventors: Jae-Heon Lee, Gha-Seung Park, Jae-Cheol Lee, Han-Kyong Kim, Young-Kil Chang, Gwan-Sun Lee
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Patent number: 6890959Abstract: Aminomethyl-phenyl-cyclohexanone derivatives of formula I or Ia, their diastereomers, enantiomers and salts formed with a physiologically tolerated acid. Also disclosed are processes for preparing the same, pharmaceutical compositions comprising the same, and methods of using the same for the treatment of pain, inflammatory reaction, allergic reactions, depression, drug abuse, alcohol abuse, gastritis, cardiovascular disease, respiratory tract disease, coughing, mental illness, epilepsy, urinary incontinence, itching, and diarrhoea.Type: GrantFiled: July 5, 2002Date of Patent: May 10, 2005Assignee: Gruenenthal GmbHInventors: Claudia Puetz, Helmut Buschmann, Babette-Yvonne Koegel
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Patent number: 6849766Abstract: 1,4-Diamino-2-alkenylbenzene derivatives of general formula (I) or physiologically tolerated water-soluble salts thereof as well as agents for oxidative dyeing of fibers, containing these compounds.Type: GrantFiled: September 10, 2001Date of Patent: February 1, 2005Assignee: Wella AktiengesellschaftInventors: Laurent Chassot, Hans-Juergen Braun
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Patent number: 6828466Abstract: A process to synthesize substituted phenols such as those of the general formula RR′R″Ar(OH) wherein R, R′, and R″ are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C—H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.Type: GrantFiled: July 15, 2003Date of Patent: December 7, 2004Assignee: Board of Trustees of Michigan State UniversityInventors: Robert E. Maleczka, Jr., Milton R. Smith, III, Daniel Holmes, Feng Shi
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Patent number: 6803388Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described. Preferred (R)-Chiral 1-Substitutedamino-(n+1)-Alkanol compounds are substituted (R)-Chiral N,N-bis-phenyl aminoalcohols. A preferred specific (R)-Chiral N,N-bis phenyl aminoclcohol is the compound.Type: GrantFiled: December 12, 2001Date of Patent: October 12, 2004Assignee: Pfizer, Inc.Inventors: James A. Sikorski, Richard C. Durley, Margaret L. Grapperhaus, Mark A. Massa, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Brian S. Hickory, Monica B. Norton, William F. Vernier, Deborah A. Mischke, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
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Patent number: 6784311Abstract: Process for the preparation of 3-aminoalkanoic acid esters of the general formula: in which R is C1-6-alkyl and R1 is hydrogen, C1-6-alkyl or phenyl, or their salts, by catalytic hydrogenation of the corresponding 3-amino-2-alkenoic acid esters of the general formula: in which R and R1 have the above mentioned meanings. The hydrogenation is carried out in the presence of a strong acid and the salt of the 3-aminoalkanoic acid ester (I) and the strong acid formed is optionally converted into the free 3-aminoalkanoic acid ester (I) or into another salt in a manner known per se.Type: GrantFiled: August 21, 2002Date of Patent: August 31, 2004Assignee: Lonza AGInventor: Rudolf Fuchs
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Patent number: 6784318Abstract: An organic electroluminescent device has an organic layer between a pair of electrodes. The organic layer (in particular, a hole-transporting layer) has a polymer of a vinyl compound represented by the following formula (1): wherein R1 and R2 are the same or different, each representing a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group. The glass transition temperature of the polymer is about 200 to 250° C., and the polymer has high heat-resistance. Thus, the use of the polymer improves heat resistance of an organic EL device.Type: GrantFiled: September 10, 2002Date of Patent: August 31, 2004Assignees: Yasuhiko Shirota, Daicel Chemical Industries Ltd.Inventors: Yasuhiko Shirota, Yutaka Ohsedo, Kazuyuki Moriwaki, Kenji Okumoto
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Patent number: 6765023Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted reverse aminoalcohols.Type: GrantFiled: May 23, 2002Date of Patent: July 20, 2004Assignee: Pfizer, Inc.Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
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Patent number: 6747175Abstract: The invention concerns a method for the synthesis of chlorinated aniline on the ring and comprising at least a sp3 hybridization carbon atom both perhalogenated and bearing a fluorine atom. Said method is characterized in that it comprises a step which consists in chlorinating a precursor aniline of said chlorinated aniline, said chlorination being carried out in a hydrofluoric medium capable of exchanging chlorine and fluorine in benzyl position. The invention is useful for the synthesis of organofluorinated and/or chlorinated compounds.Type: GrantFiled: October 21, 2002Date of Patent: June 8, 2004Assignee: Rhodia ChimieInventors: Hubert Kempf, Gilbert Guidot, Laurent Saint-Jalmes
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Patent number: 6747149Abstract: N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combination of such other agents.Type: GrantFiled: December 17, 2002Date of Patent: June 8, 2004Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis
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Publication number: 20040092762Abstract: The present invention relates to polyhaloalkylaryls, to a process for preparing them and to the use of the polyhaloalkylaryls for preparing active ingredients.Type: ApplicationFiled: November 7, 2003Publication date: May 13, 2004Inventors: Albrecht Marhold, Axel Pleschke
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Publication number: 20040073032Abstract: A process for preparing compounds of the formula (II), 1Type: ApplicationFiled: October 2, 2003Publication date: April 15, 2004Applicant: Clariant GmbHInventors: Andreas Meudt, Michael Erbes, Klaus Forstinger
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Patent number: 6717013Abstract: The present invention provides an aniline derivative represented by the formula (I) wherein R1 and R2 are each H, (C1-12)alkyl, (C3-8)cycloalkyl, hydroxy(C1-12)alkyl, hydroxycarbonyl (C1-12)alkyl, (C1-6)-alkoxycarbonyl(C1-6)alkyl, —COR8, wherein R8 is H, halo-(C1-12)alkyl, (C3-8)cycloalkyl or (substituted) phenyl, COOR9, wherein R9 is a halo(C1-6)alkyl group, (substituted) phenyl or (substituted) benzyl; R3, R4, R5, R6 and R7 are each H, halogen, OH, nitro, halo(C1-12)alkylthio, (substituted) amino-(C1-2)alkyl, (substituted) phenyl, (substituted) benzyl, amino, —N(R10)R11 wherein R10 and R11 are each H, alkyl, cycloalkyl, (substituted) phenyl, (substituted) benzyl, —COR8 or COOR9, or (C2-27)perfluoroalkyl, etc., and a process for producing the aniline derivative. According to the process of the present invention, perfluoroalkylaniline derivatives can be obtained by using various anilines as the substrate with a high position selectivity and high yield.Type: GrantFiled: May 14, 2003Date of Patent: April 6, 2004Assignee: Nihon Nohyaku Co., Ltd.Inventors: Masanobu Onishi, Akihiko Yoshiura, Eiji Kohno, Kenji Tsubata
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Patent number: 6683099Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted cycloalkyl aminoalcohols.Type: GrantFiled: May 23, 2002Date of Patent: January 27, 2004Assignee: Pharmacia CorporationInventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
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Patent number: 6673794Abstract: A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are method for preparing the substituted aminomethyl-phenyl-cyclohexane derivative, pharmaceutical compositions comprising the same and method of using the same for treating pain, urinary incontinence, itching, diarrhea, inflammatory and allergic reactions, depression, drug or alcohol abuse, gastritis, cardiovascular diseases, respiratory tract diseases, coughing, mental illnesses and epilepsy.Type: GrantFiled: July 5, 2002Date of Patent: January 6, 2004Assignee: Gruenenthal GmbHInventors: Claudia Puetz, Wolfgang Strassburger, Babette-Yvonne Koegel
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Publication number: 20030225292Abstract: The present invention provides compounds and methods that can be used to convert the intermmediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.Type: ApplicationFiled: April 14, 2003Publication date: December 4, 2003Applicant: Aerojet Fine Chemicals LLC, a Delaware limited liability companyInventors: Aslam A. Malik, Todd E. Clement, Hasan Palandoken, James Robinson, Joy A. Stringer
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Patent number: 6600074Abstract: The present invention provides an aniline derivative represented by the formula (I) wherein R1 and R2 are each H, (C1-12)alkyl, (C3-8)cycloalkyl, hydroxy(C1-12)alkyl, hydroxycarbonyl (C1-12)alkyl, (C1-6)-alkoxycarbonyl(C1-6)alkyl, —COR8, wherein R8 is H, halo-(C1-12)alkyl, (C3-8)cycloalkyl or (substituted) phenyl, COOR9, wherein R9 is a halo(C1-6)alkyl group, (substituted) phenyl or (substituted) benzyl; R3, R4, R5, R6and R7 are each H, halogen, OH, nitro, halo(C1-12)alkylthio, (substituted)amino-(C1-2)alkyl, (substituted) phenyl, (substituted) benzyl, amino, —N(R10)R11 wherein R10 and R11 are each H, alkyl, cycloalkyl, (substituted) phenyl, (substituted) benzyl, —COR8 or COOR9, or (C2-27)perfluoroalkyl, etc., and a process for producing the aniline derivative. According to the process of the present invention, perfluoroalkylaniline derivatives can be obtained by using various anilines as the substrate with a high position selectivity and high yield.Type: GrantFiled: July 29, 2002Date of Patent: July 29, 2003Assignee: Nihon Nohyaku Co., Ltd.Inventors: Masanobu Onishi, Akihiko Yoshiura, Eiji Kohno, Kenji Tsubata
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Publication number: 20030130542Abstract: The invention concerns a method for the synthesis of chlorinated aniline on the ring and comprising at least a sp3 hybridisation carbon atom both perhalogenated and bearing a fluorine atom. Said method is characterized in that it comprises a step which consists in chlorinating a precursor aniline of said chlorinated aniline, said chlorination being carried out in a hydrofluoric medium capable of exchanging chlorine and fluorine in benzyl position. The invention is useful for the synthesis of organofluorinated and/or chlorinated compounds.Type: ApplicationFiled: October 21, 2002Publication date: July 10, 2003Inventors: Hubert Kempf, Gilbert Guidot, Laurent Saint-Jalmes
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Publication number: 20030105350Abstract: A process for thermal benzylic bromination of a wide variety of benzylic compounds is described. Bromine is used as the bromination agent. Moderate temperatures are employed and the process can be used to produce in relatively pure form either mono- or dibrominated benzylic bromination products.Type: ApplicationFiled: December 5, 2001Publication date: June 5, 2003Inventors: Max K. Mortensen, Hassan Y. Elnagar, Ranjit K. Roy, Robert C. Herndon,, Robert H. Allen, David A. Caillet
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Patent number: 6559341Abstract: The present invention provides a phthalic acid diamide derivative represented by the general formula (I) (wherein R1, R2 and R3 are each H, C3-C6 cycloalkyl group, group of the formula —A1—Ql or the like; X may be the same or different and are each halogen atom, nitro group, phenyl group, group of the formula —A2—R7 or the like; n is 1 to 4; Y may be same or different and are each halogen atom, cyano group, phenyl group, group of the formula —A2—R7 or the like; m is 1 to 5; Z1 and Z2 are each O or S), fluorine-containing aniline compound represented by the general formula (ST-I) as starting material for said phthalic acid diamide derivative (wherein Ra is halogen atom, C1-C6 alkyl group or the like and Rb, Rc and Rd is H or C2-C6 perfluoroalkyl group), and an agricultural and horticultural insecticide containing said phthaldiamide derivative, as well as to provide a method for use of said insecticide.Type: GrantFiled: January 4, 2002Date of Patent: May 6, 2003Assignee: Nihon Nohyaku Co., Ltd.Inventors: Masanori Tohnishi, Hayami Nakao, Eiji Kohno, Tateki Nishida, Takashi Furuya, Toshiaki Shimizu, Akira Seo, Kazuyuki Sakata, Shinsuke Fujioka, Hideo Kanno
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Patent number: 6555959Abstract: A material for a light emitting device which is a compound represented by the following formula (I): wherein Ar1 and Ar6, which are the same or different, each represents a divalent aryl group or a divalent heterocyclic group; R2, R3, R7 and R8, which are the same or different, each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group; R4a, R5a, R9a and R10a, which are the same or different, each represents a hydrogen atom or a monovalent group, and at least one of R4a, R5a, R9a and R10a represents an electron withdrawing group having a Hammett's &sgr;p value of 0.Type: GrantFiled: September 29, 2000Date of Patent: April 29, 2003Assignee: Fuji Photo Film Co., Ltd.Inventor: Kazumi Nii
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Patent number: 6552214Abstract: A compound comprises a blocked halogenated hydroxydiphenyl ether of the formula: where X1 is a halogen, X2 is chlorine or bromine, X3 is hydrogen, chlorine or bromine, X4 is chlorine, bromine, alkyl having 1 to 3 carbon atoms, —CHO, —CN or —NH2, X5 is chlorine, bromine, methyl, trichloromethyl, —CHO, —CN or —NH2, n is 1 or 2, and R is an ether linkage inhibiting group.Type: GrantFiled: May 4, 2000Date of Patent: April 22, 2003Assignee: General Electric CompanyInventors: Frank John Mondello, Ralph Joseph May
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Patent number: 6552161Abstract: The present invention relates to amine compositions and the preparation of polyimides. The polyimides can be used for inducing alignment of a liquid crystal medium with polarized light in liquid crystal display elements.Type: GrantFiled: March 28, 2000Date of Patent: April 22, 2003Assignee: Elsicon, Inc.Inventors: Wayne M. Gibbons, Paul J. Shannon, Hanxing Zheng
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Publication number: 20030073847Abstract: The dihalopropene compounds of the general formula (I) have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.Type: ApplicationFiled: March 4, 2002Publication date: April 17, 2003Applicant: Sumitomo Chemical Company, LimitedInventors: Noriyasu Sakamoto, Sanshiro Matsuo, Masaya Suzuki, Taro Hirose, Kazunori Tsushima, Kimitoshi Umeda
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Patent number: 6521794Abstract: For the production of an aromatic compound by hydrolyzing and decarboxylating a corresponding aromatic cyano compound in the presence of an acidic substance, this invention provides a method for the production of the aromaic compound, characterized by carrying out the reactions of hydrolysis and decarboxylaion in multiple steps. Particularly when the aromatic cyano compound contains a halogen, this method effectively prevents the reaction vessels from being corroded by the by-produced hydrogen halogenide and enables the target compound to be produced in a high yield.Type: GrantFiled: February 1, 2002Date of Patent: February 18, 2003Assignee: Nippon Shokubai Co., Ltd.Inventor: Kouichi Hirota
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Patent number: 6521793Abstract: New ligands having a backbone comprised of NCCX can be combined with a metal or metal precursor compound or formed into a metal-ligand complex to catalyze a number of different chemical transformations, including polymerization.Type: GrantFiled: October 8, 1998Date of Patent: February 18, 2003Assignee: Symyx Technologies, Inc.Inventors: Anil S. Guram, Anne Marie LaPointe, Howard W. Turner, Tetsuo Uno
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Patent number: 6509503Abstract: The invention relates to processes for the preparation of compounds of formula (I) wherein R1 and R2 each independently represent a halogen atom.Type: GrantFiled: May 3, 2002Date of Patent: January 21, 2003Assignee: Aventis Cropscience S.A.Inventors: Jean-Erick Angel, Gilles Perrin-Janet, Pierre Leroy
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Publication number: 20030012730Abstract: According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiolabelled haloaromatics are disclosed, as well as processes for the preparation of the intermediate precursor insoluble polymer compounds.Type: ApplicationFiled: August 20, 2002Publication date: January 16, 2003Inventors: Duncan H. Hunter, Xizhen Zhu
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Patent number: 6504059Abstract: Process for converting a nitrobenzene into a free aminophenol by catalytic reduction hydroxylation in the presence of an aqueous-acidic reaction medium.Type: GrantFiled: February 11, 1999Date of Patent: January 7, 2003Assignee: Bayer AktiengesellschaftInventors: Franz-Josef Mais, Albrecht Marhold, Guido Steffan
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Patent number: 6492515Abstract: The present invention relates to benzoxazinones of formula I: or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, methods of using the same for treating viral infection or as an assay standard or reagent, and intermediates and processes for making the same.Type: GrantFiled: July 31, 2001Date of Patent: December 10, 2002Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Joseph Marian Fortunak, Mona Patel
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Patent number: 6485799Abstract: A aniline derivative represented by general formula (1) wherein R and R′ represent independently each other alkyl with 1 to 10 carbon, alkoxyalkyl with 1 to 10 carbon, or hydrogen; x represents cyano, halogen, haloalkyl, haloalkyloxy, or 2-cyanoethynyl; Y represents fluorine or hydrogen; na and nc represent independently each other 0 or 1; Za, Zb, and Zc represent independently each other a single bond, 1,2-ethylene, carbonyloxy, or oxymethylene; ring A1 represents 1,4-phenylene in which hydrogen may be substituted by fluorine; ring A2 and ring A3 represent independently each other 1,4-cyclohexylene, 1,4-phenylene in which hydrogen may be substituted by fluorine, or 1,3-pyrimidine-2,5-diyl.Type: GrantFiled: July 24, 2000Date of Patent: November 26, 2002Assignee: Chisso CorporationInventors: Atsuko Fujita, Norio Tamura, Hiroyuki Tekeuchi, Fusayuki Takeshita, Nobumasa Nakamura, Etsuo Nakagawa
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Patent number: 6476057Abstract: The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted cycloalkyl aminoalcohols.Type: GrantFiled: November 14, 2001Date of Patent: November 5, 2002Assignee: G.D. Searle & Co.Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
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Patent number: 6458852Abstract: The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N- bis-phenyl aminoalcohols.Type: GrantFiled: November 14, 2001Date of Patent: October 1, 2002Assignee: G.D. Searle & Co.Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
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Publication number: 20020123652Abstract: 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions. for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.Type: ApplicationFiled: March 22, 2000Publication date: September 5, 2002Inventors: Nicola Fanto, Gian Piero Moretti, Piero Foresta
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Patent number: 6410737Abstract: Compounds of formula (I) are prepared by hydrogenolysis of a compound of formula (II): where R1 is haloalkyl, haloalkoxy or −SF5; W is N or CR3; and R2 and R3 are H or Cl. The compounds of formula (I) can be used as intermediates in the preparation of pesticidally active arylpyrazole compounds.Type: GrantFiled: January 4, 2002Date of Patent: June 25, 2002Assignee: Aventis CropScience, S.A.Inventors: Jean-Erick Ancel, Gilles Perrin-Janet, Manuel Vangelisti, Pierre Versproumy
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Patent number: 6344558Abstract: 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.Type: GrantFiled: April 20, 2001Date of Patent: February 5, 2002Assignee: Gruenthal GmbHInventors: Helmut Buschmann, Wolfgang Strassburger, Elmar Friderichs
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Publication number: 20020010370Abstract: Bis-o-aminophenols and o-aminophenolcarboxylic acids have the following structures: 1Type: ApplicationFiled: March 12, 2001Publication date: January 24, 2002Inventors: J?ouml;rg Haussmann, Gerhard Maier, Recai Sezi
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Patent number: 6335303Abstract: The present invention describes methods of making a series of amine-containing organic compounds which are used as ligands for group 3-10 and lanthanide metal compounds. The ligands have electron-withdrawing groups bonded to them. The metal compounds, when combined with a cocatalyst, are catalysts for the polymerization of olefins.Type: GrantFiled: February 16, 2000Date of Patent: January 1, 2002Assignee: The Regents of the University of CaliforniaInventors: John G. Watkin, Damon R. Click