Hydroxy, Bonded Directly To Carbon, Or Ether Containing (h Of -oh May Be Replaced By A Substituted Or Unsubstituted Ammonium Ion Or A Group Ia Or Iia Light Metal) Patents (Class 564/443)
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Publication number: 20110313158Abstract: The invention describes the development of highly efficient, recyclable two component system, CuAl-hydrotalcite/rac 1,1?-Binaphthalene-2,2?-diol catalytic system for the N-alkylation of electron deficient aryl chlorides in presence of potassium carbonate as a base at room temperature in 3-6 h, wherein the process is provided for the preparation of various secondary amines via C—N coupling reaction of aliphatic amines(aliphatic open chain, acyclic, benzyl amines and heterocyclic amines) with various aryl chlorides.Type: ApplicationFiled: February 26, 2010Publication date: December 22, 2011Inventors: Pravin R. Likhar, R. Arundhati, M. Lakshmi Kantam
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Publication number: 20110306673Abstract: This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.Type: ApplicationFiled: February 21, 2006Publication date: December 15, 2011Applicant: GRUENENTHAL GMBHInventors: Michael Gruss, Helmut Buschmann, Andreas Fischer, Wolfgang Hell, Dagmar Lischke
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Publication number: 20110305618Abstract: The invention pertains to a method for eluting a radionuclide-label or a radionuclide-labeled compound using a solid phase extraction resin, to a device for performing such a method, and to a computer program for controlling such a device.Type: ApplicationFiled: December 12, 2009Publication date: December 15, 2011Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Keith Graham, Axel Rother, Dominic Franck
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Publication number: 20110295038Abstract: A process for the preparation of substituted 1-aminomethyl-2-phenyl-cyclohexane compounds.Type: ApplicationFiled: May 27, 2011Publication date: December 1, 2011Applicant: Gruenenthal GmbHInventors: Joerg HOLENZ, Helmut Heinrich Buschmann
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Publication number: 20110295012Abstract: Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7 or —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from niType: ApplicationFiled: August 3, 2011Publication date: December 1, 2011Inventors: Kenneth Alan Simmen, Herman Augustinus De Kock, Pierre Jean-Marie Bernard Raboisson, Lili Hu, Abdellah Tahri, Dominque Louis Nestor Ghislai Surleraux, Karl Magnus Nilsson, Bengt Bertil Samuelsson, Asa Annica Kristina Rosenquist, Vladimir Ivanov, Michael Pelcman, Anna Karin Gertrud Linnea Belfrage, Per-Ola Mikael Johansson, Sandrine Marie Helene Vendeville
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Publication number: 20110263699Abstract: Metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament used for treating depression, and related methods of treating depression, pain and urinary incontinence.Type: ApplicationFiled: July 1, 2011Publication date: October 27, 2011Applicant: GRUENENTHAL GmbHInventors: Elmar Friderichs, Wolfgang Strassburger, Ulrich Jahnel, Derek Saunders, Hagen-Heinrich Hennies, Werner Englberger, Helmut Buschmann, Joerg Holenz, Oswald Zimmer
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Patent number: 8039672Abstract: The invention relates to a method of obtaining 3,3-diphenylpropylamines (I), wherein R1 is H, alkyl, haloalkyl or alkoxyalkyl, R2 is alkyl, alkoxy, halogen, NO2, CN, CHO, which may be free or protected, CH2OH or COOR6, and R3 and R4 are selected independently from H and alkyl or together with the nitrogen to which they are bound form a ring having 3 to 7 members. The inventive method consists in reacting a propylenephenylamine and a disubstituted aromatic hydrocarbon and, if necessary, separating the desired enantiomer or the mixture of enantiomers, and/or converting the compound (I) into a salt. Compounds (I) are muscarinic receptor antagonists which can be used in the treatment of urinary incontinence and other symptoms of urinary bladder hyperactivity. Said compounds include tolterodine.Type: GrantFiled: August 3, 2006Date of Patent: October 18, 2011Assignee: Interquim, S.A.Inventors: Antonio Lorente Bonde-Larsen, Pablo Martin Pascual, Jorge Martin Juarez, Miquel Armengol Montserrat
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Publication number: 20110251198Abstract: Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.Type: ApplicationFiled: April 12, 2011Publication date: October 13, 2011Applicant: Supernus Pharmaceuticals Inc.Inventors: Likan Liang, Padmanabh P. Bhatt, David Dain, Jean-Philippe Taquet, Aleksandr Pechenov, Alexei Tchesnokov, Reynold Mariaux
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Publication number: 20110245477Abstract: The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.Type: ApplicationFiled: February 8, 2011Publication date: October 6, 2011Applicants: Trustees of Boston College, Massachusetts Institute of TechnologyInventors: Amir H. Hoveyda, Simon J. Meek, Robert V. O'Brien, Josep Llaveria Cros, Richard R. Schrock
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Publication number: 20110245541Abstract: A compound of the formula wherein R1, R2, R3, and R4 can be the same or different, and wherein each of R1, R2, R3, and R4 are independently selected from (i) hydrogen, (ii) an alkyl group, (iii) an aryl group, (iv) an arylalkyl group, (v) an alkylaryl group, (vi) an alkoxy group, (vii) an aryloxy group, (viii) an arylalkyloxy group, (ix) an alkylaryloxy group; and wherein R5 is (i) an alkylene group, (ii) an arylene group, which can be substituted or unsubstituted arylene, and wherein hetero atoms may optionally be present in the arylene group, (iii) an arylalkylene group, or (iv) an alkylarylene group. Further, a process for preparing a charge transport compound comprises contacting a hydroxy-functionalized triarylamine with a dihalide in an alkaline-water solution at room temperature; wherein the raw material for the dihalide comprises a purified or recovered halogen-organic solvent-containing waste stream.Type: ApplicationFiled: April 1, 2010Publication date: October 6, 2011Applicant: XEROX CORPORATIONInventor: Yuhua Tong
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Publication number: 20110237799Abstract: The invention relates to methods for carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and/or carbon-oxygen bond forming reactions using phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3, and Ar4 are as defined herein in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex.Type: ApplicationFiled: April 1, 2011Publication date: September 29, 2011Applicant: HOKKO CHEMICAL INDUSTRY CO., LTD.Inventors: Shin MASAOKA, Hideyuki IWAZAKI
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Patent number: 8022252Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.Type: GrantFiled: August 25, 2008Date of Patent: September 20, 2011Assignee: Tranzyme Pharma Inc.Inventors: Pierre Deslongchamps, Yves Dory, Kamel Benakli, Éric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vezina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gérald Villeneuve, Hamid R. Hoveyda, Sylvie Beaubien, Mark L. Peterson
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Patent number: 8017807Abstract: A new tetrahydroxy compound having a specific structure including two 2,3-dihydroxypropyloxy groups is provided. The compound has good charge transport property. In addition, a charge transport layer including the tetrahydroxy compound or a reaction product of the tetrahydroxy compound is provided. Further, a charge transport layer coating liquid is provided which includes the tetrahydroxy compound, and an alcohol. Furthermore an electrophotographic photoreceptor is provided which includes an electroconductive substrate, a charge generation layer, a charge transport layer and an outermost layer including the tetrahydroxy compound or a reaction product of the tetrahydroxy compound.Type: GrantFiled: November 21, 2006Date of Patent: September 13, 2011Assignee: Ricoh Company LimitedInventors: Kazukiyo Nagai, Tamotsu Horiuchi
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Publication number: 20110212173Abstract: There is described a pharmaceutical composition for controlled release of an active compound wherein the active compound is selected from the group comprising tramadol, resveratrol, acetaminophen, xorphanol, cinfenoac, furcloprofen, bismuth subsalicylate, enofelast, triflusal, ketorfanol, indriline, furofenac, cizolirtine, dacemazine, demelverine, and fenethazine, and derivatives and/or combinations thereof for the treatment or alleviation of depression. More particularly, there is described an abuse resistant pharmaceutical composition for the treatment of inter alia, depression and controlled release pharmaceutical compositions of related thereto.Type: ApplicationFiled: June 17, 2009Publication date: September 1, 2011Applicant: e-Therapeutics PleInventors: Malcolm Philip Young, Olusola Clement Idowu, Philip McKeown
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Publication number: 20110208064Abstract: The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid ? aggregates, these probes undergo a range of changes, qualifying them as “smart” probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid ? aggregates and plaques.Type: ApplicationFiled: July 31, 2009Publication date: August 25, 2011Inventors: Ran Chongzhao, Anna Moore
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Publication number: 20110195979Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.Type: ApplicationFiled: February 7, 2011Publication date: August 11, 2011Inventors: Li Chen, Xianfeng Lin, Zongxing Qiu, Guozhi Tang, Lisha Wang, Jim Zhen Wu, Wengang Yang
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Publication number: 20110189269Abstract: The present invention relates to a once daily extended release pharmaceutical preparation of Tramadol or its acceptable pharmaceutical salts. The preparation provides, effective blood concentration for a period of about 24 hours with reduced peak concentrations. It is characterized that effective Tramadol levels appear within the first hours after administration, the time to maximal Tramadol content Tmax is at least 10 hours and the peak Tramadol concentration is less than three times the concentration obtained after 24 hours of said administration.Type: ApplicationFiled: November 18, 2010Publication date: August 4, 2011Applicant: GALEPHAR PHARMACEUTICAL RESEARCH, INC.Inventors: Arthur M. Deboeck, Francis Vanderbist, Antonio Sereno
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Publication number: 20110190540Abstract: Disclosed herein are methods of making compounds which are agonists or antagonists of one or more of the individual receptors of the S1P receptor family.Type: ApplicationFiled: September 24, 2010Publication date: August 4, 2011Applicant: ABBOTT LABORATORIESInventors: Shashank Shekhar, Su Yu, Anthony R. Haight, Preston E. Chmura, Vimal Kishore
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Publication number: 20110160228Abstract: The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.Type: ApplicationFiled: June 4, 2009Publication date: June 30, 2011Inventors: Mouâd Alami, Samir Messaoudi, Abdallah Hamze, Olivier Provot, Jean-Daniel Brion, Jian-Miao Liu, Jérôme Bignon, Joanna Bakala
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Publication number: 20110144390Abstract: A process for preparing O-alkylated amino alcohols by reacting N-unsubstituted or N-monosubstituted amino alkoxide salts with alkyl halides, the amino alkoxide salts being formed by means of alkali metal or alkaline earth metal hydroxides.Type: ApplicationFiled: December 11, 2006Publication date: June 16, 2011Applicant: BASF SEInventors: Wolfgang Siegel, Gerd Haderlein, Tobias Stab
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Patent number: 7960588Abstract: Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.Type: GrantFiled: March 29, 2010Date of Patent: June 14, 2011Assignee: University of Virginia Patent FoundationInventors: Kevin R. Lynch, Timothy L. Macdonald
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Publication number: 20110110871Abstract: Certain novel substituted 3-(phenoxymethyl) benzyl amines and personal care compositions comprising such, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.Type: ApplicationFiled: November 9, 2009Publication date: May 12, 2011Applicant: CONOPCO, INC., D/B/A UNILEVERInventors: Jose Guillermo ROSA, Bijan HARICHIAN, John Steven BAJOR, Carol Annette BOSKO, Diana Jean DRENNAN, John Chun-Sing NIP
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Publication number: 20110082176Abstract: The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.Type: ApplicationFiled: October 15, 2010Publication date: April 7, 2011Inventors: Norman C.W. Wong, Joseph E.L. Tucker, Henrik C. Hansen, Fabrizio S. Chiacchia, David McCaffrey
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Publication number: 20110081607Abstract: A methylol compound having a specific formula such that two triphenylamine groups each having two methylol groups are connected with each other by an oxygen atom, a methylene group, a vinylene group, or an ethylene group. The methylol compound is preferably prepared by subjecting a corresponding aldehyde compound to a reduction reaction in the presence of a reducing agent. The methylol compound is preferably used as a charge transport material.Type: ApplicationFiled: September 22, 2010Publication date: April 7, 2011Applicant: RICOH COMPANY, LTD.,Inventors: Yuuji Tanaka, Norio Nagayama
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Publication number: 20110060053Abstract: Crystalline modifications of (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol, (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol and mixtures thereof, pharmaceutical compositions and medicaments comprising these modifications, the use of these modifications as well as to a process for the enrichment of (1R,3R,6R)- or (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol.Type: ApplicationFiled: September 13, 2010Publication date: March 10, 2011Applicant: Gruenenthal GmbHInventors: Michael Gruss, Helmut Heinrich Buschmann
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Publication number: 20110054217Abstract: The present invention relates to a process for the asymmetric hydrogenation of imines with hydrogen under elevated pressure in the presence of a catalyst system. In particular the present invention relates to the use of the said catalytic system for the enantioselective hydrogenation of prochiral ketimines to asymmetric amines leading to the formation of herbicides.Type: ApplicationFiled: April 16, 2009Publication date: March 3, 2011Applicant: UNITED PHOSPHORUS LIMITEDInventors: Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff, Birja Shanker
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Publication number: 20110053778Abstract: 2-(3-Aminobenzoyl)-3-cyclopropyl-3-oxopropanenitriles of the formula (I) are described as herbicides. In this formula (I), X and Y are organic radicals such as alkyl and other radicals such as halogen, nitro and cyano.Type: ApplicationFiled: July 27, 2010Publication date: March 3, 2011Applicant: BAYER CROPSCIENCE AGInventors: Hartmut AHRENS, Ines Heinemann, Andreas Van Almsick, Ralf Braun, Jan Dittgen, Dieter Feucht, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger, Stefan Lehr
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Patent number: 7893304Abstract: The present invention provides compounds that are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.Type: GrantFiled: February 23, 2006Date of Patent: February 22, 2011Assignee: Meiji Dairies CorporationInventors: Bang Luu, Dominique Bagnard, Mazen Hanbali, Masashi Yamada, Hiroto Suzuki
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Publication number: 20110002985Abstract: An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.Type: ApplicationFiled: August 12, 2008Publication date: January 6, 2011Applicant: ABUSE DETERRENT PHARMACEUTICAL, LLCInventors: Manish J. Shah, Ray J. Difalco
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Publication number: 20100330025Abstract: The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface.Type: ApplicationFiled: June 3, 2010Publication date: December 30, 2010Applicant: Northwestern UniversityInventors: Phillip B. Messersmith, Andrea R. Statz Sloan, Bruce P. Lee, Jeffrey L. Dalsin, Daniel Sherman, Haeshin Lee
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Patent number: 7858826Abstract: A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.Type: GrantFiled: February 27, 2009Date of Patent: December 28, 2010Assignee: Gruenenthal GmbHInventors: Wolfgang Hell, Oswald Zimmer, Markus Kegel, Olaf Schaefer, Felix Spindler, Anita Schnyder, Urs Siegrist, Detlef Heller, Hans-Joachim Drexler
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Publication number: 20100324285Abstract: An object of the present invention is to provide anti-inflammatory agent having an excellent effect and less adverse side-effects. The object is attained by providing an anti-inflammatory agent comprising 2-aminophenol or a derivative thereof as an effective ingredient.Type: ApplicationFiled: October 15, 2007Publication date: December 23, 2010Inventors: Masaki Miyake, Keizo Kohno, Osamu Sano
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Publication number: 20100286434Abstract: New ethylenically unsaturated monomers are provided that can be (co)polymerized to provide a composition and method whereby the same group that is attached to or within the backbone of an associative thickener is reversibly switched between being hydrophilic and hydrophobic in nature. When the group that is attached to or within the backbone is rendered hydrophilic, the aqueous thickener is pourable and readily incorporated into aqueous polymer compositions. When this group is rendered hydrophobic, the thickener performs its thickening function efficiently. Switching is readily accomplished by adjusting the pH of the associative thickener composition and the aqueous polymer composition being thickened. The thickeners are prepared from the novel monomers by an aqueous solution polymerization.Type: ApplicationFiled: May 28, 2010Publication date: November 11, 2010Inventors: Barrett Richard Bobsein, Melissa Merlau Johnson, Thomas Glenn Madle, John Joseph Rabasco
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Publication number: 20100279340Abstract: Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.Type: ApplicationFiled: February 11, 2008Publication date: November 4, 2010Applicant: NYUInventors: Thomas Wisniewski, Jaeki Min, Qian Li, Young-Tae CHANG
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Publication number: 20100280273Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with bidentate ligands, having one amino or imino coordinating group and one phosphino coordinating group, in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.Type: ApplicationFiled: July 20, 2010Publication date: November 4, 2010Inventors: Lionel Saudan, Philippe Dupau, Jean-Jacques Riedhauser, Patrick Wyss
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Publication number: 20100272642Abstract: Disclosed are: a PET probe compound having an alkoxy group substituted by a fluorine and a hydroxy group, which is useful for the early diagnosis of a conformational disease; a pharmaceutical composition for the treatment and/or prevention of a conformational disease, which comprises the compound; and others.Type: ApplicationFiled: June 17, 2008Publication date: October 28, 2010Applicant: TOHOKU UNIVERSITYInventors: Yukitsuka Kudo, Syozo Furumoto, Nobuyuki Okamura
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Publication number: 20100249074Abstract: Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.Type: ApplicationFiled: March 29, 2010Publication date: September 30, 2010Inventors: Kevin R. Lynch, Timothy L. Macdonald
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Publication number: 20100240712Abstract: Novel aromatic compounds of formula (I): wherein A1, A2, A3, A4, R1, R2, R5, G1, G2, Q1, Q2, Y1, Y2, Y3 and Y4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests.Type: ApplicationFiled: October 13, 2008Publication date: September 23, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Andre Denis Stoller, Pierre Joseph Marcel Jung, Christopher Richard Ayles Godfrey, William Lutz, Peter Maienfisch, Werner Zambach
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Publication number: 20100215710Abstract: Methods for increasing rate of healing of wounds in epithelial tissues by administration of beta-2 adrenergic receptor antagonists to target patients are provided. Methods for decreasing cell growth around implanted devices and methods for decreasing wound contraction by administration of beta-2 adrenergic receptor agonists are also provided. Pharmaceutical compositions and kits including beta-2 adrenergic receptor agonists and antagonists are described, as are devices coated with beta-2 adrenergic receptor agonists.Type: ApplicationFiled: April 10, 2006Publication date: August 26, 2010Inventors: Roslyn Rivkah Isseroff, Christine E. Pullar
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Publication number: 20100197915Abstract: The invention provides lapatinib intermediates and improved processes for preparing lapatinib intermediates. The invention also provides processes for preparing lapatinib base and lapatinib ditosylate.Type: ApplicationFiled: August 6, 2009Publication date: August 5, 2010Inventors: Leonid METSGER, Slavik YURKOVSKI, Sofia GOROHOVSKY-ROSENBERG, Noa KIPNIS, Dikla LAVY
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Publication number: 20100190861Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.Type: ApplicationFiled: January 15, 2010Publication date: July 29, 2010Inventors: Liming Shao, Fengjiang Wang, Scott Christopher Malcolm, Michael Charles Hewitt, Larry R. Bush, Jianguo Ma, Mark A. Varney, Una Campbell, Sharon Rae Engel, Larry Wendell Hardy, Patrick Koch, John E. Campbell
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Patent number: 7763754Abstract: A process for producing (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or mixtures thereof.Type: GrantFiled: February 27, 2009Date of Patent: July 27, 2010Assignee: Gruenenthal GmbHInventors: Helmut Heinrich Buschmann, Wolfgang Hell, Joerg Holenz, Oswald Zimmer, Irene Vaulont, Dieter Haag, Emad El Sayed, Robert Hett, Alfed Olbrich, Lars Pumpenmeier
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Publication number: 20100168161Abstract: The present relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds of formula (I), and to their methods of use in therapy.Type: ApplicationFiled: October 17, 2007Publication date: July 1, 2010Applicant: LABORATORIOS ALMIRALL, S.A.Inventors: Jordi Bach Tanã, Maria Isabel Crespo, Carlos Puig Duran, Silvia Gual Roig, Alberto Ortega Münoz
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Publication number: 20100160645Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.Type: ApplicationFiled: May 29, 2009Publication date: June 24, 2010Applicant: Intezyne Technologies, Inc.Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
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Publication number: 20100160195Abstract: Aniline compounds useful as ashless TBN sources for lubricating oil compositions that are compatible with fluoroelastomeric engine seal materials, and lubricating oil compositions containing such aniline compounds.Type: ApplicationFiled: December 23, 2008Publication date: June 24, 2010Inventors: Jie Cheng, Jacob Emert
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Publication number: 20100160247Abstract: The present invention is directed to a process for preparing a 2,26,6-d4-morpholine derivative represented by Structural Formula (I): or a salt thereof.Type: ApplicationFiled: June 17, 2009Publication date: June 24, 2010Applicant: CoNCERT Pharmaceuticals, Inc.Inventors: Julie F. Liu, Xuejun Tang, Scott L. Harbeson, Craig E. Masse
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Publication number: 20100121020Abstract: The invention provides 3,3?-diamino-5,5?-diphenyl-4,4?-biphenyldiol which is useful as a monomer for a high-performance polymer, particularly a polymer satisfying performances highly required in the semiconductor field such as polybenzoxazole, polyimide or the like and 3,3?-dinitro-5,5?-diphenyl-4,4?-biphenyldiol as a raw material thereof. Also, the invention provides a polybenzoxazole having a repeating unit represented by the following formula (1): (wherein R is a bivalent dicarboxylic acid residue).Type: ApplicationFiled: March 18, 2008Publication date: May 13, 2010Applicant: NIPPONKAYAKU KABUSHIKIKAISHAInventors: Kenji Kunikata, Taihei Koumoto, Kenji Sekine
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Publication number: 20100068553Abstract: The invention relates to a novel ultra-thin hydrophobic and oleophobic layer, formed by self-assembly on a solid substrate surface, of compounds of the general formula A-B in which A represents a group of the formula in which Z represents C or N+, X represents C—H or C-L, L being an electron-attracting group selected from F, Cl, Br, I, CF3, NO2 and N(CH3)3+, Y represents H or CH3, or Y forms a 5- or 6-atom heterocycle with X, T represents NH, CO, CONH or NH2+U?, U? being a soluble anion such as e.g. F?, Cl?, Br?, I, OH?, NO3?, HSO4?, SO42?, CO32?, HCO3? or SCN?, and B represents a C1-C20 linear aliphatic alkyl group partially or completely substituted with F, and a method of preparing this layer and its use as an epilame.Type: ApplicationFiled: November 29, 2007Publication date: March 18, 2010Applicant: ROLEX S.A.Inventors: Samuele Tosatti, Stefan Zurcher
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Patent number: 7667078Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula: (wherein, Y is divalent hydrocarbon and R1 is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons).Type: GrantFiled: March 9, 2005Date of Patent: February 23, 2010Assignee: Japan Science and Technology AgencyInventors: Shu Kobayashi, Haruro Ishitani, Yasuhiro Yamashita
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Publication number: 20100022656Abstract: The invention provides compounds of formula (I) having (?) or (+) configuration, or pharmaceutically acceptable salts thereof, wherein R1 is H or halo; R2 is CF3, CN, or halo; R3 is linear or branched alkyl having 1 to 6 carbon atoms, or cycloalkyl having 3 to 6 carbon atoms. The invention also relates to methods for preparing the said compounds and the composition comprising the same. The compounds of the present invention have the effect of ?2-receptor agonist and can be used for the treatment of asthma or bronchitis.Type: ApplicationFiled: July 2, 2007Publication date: January 28, 2010Applicant: SHENYANG PHARMACEUTICAL UNIVERSITYInventors: Maosheng Cheng, Li Pan, Dongkai Wang, Ruijuan Xing, Xuyao Chen, Dongmei Zhao