Hydroxy, Bonded Directly To Carbon, Or Ether Containing (h Of -oh May Be Replaced By A Substituted Or Unsubstituted Ammonium Ion Or A Group Ia Or Iia Light Metal) Patents (Class 564/503)
  • Patent number: 8211945
    Abstract: Methods for stabilizing ?-galactosidase, stabilizing ?-glucocerebrosidase, treating a glycolipid metabolic disorder caused by mutation of ?-galactosidase gene, treating a glycolipid metabolic disorder caused by mutation of ?-glucocerebrosidase gene, regenerating the activity of ?-galactosidase, regenerating the activity of ?-glucosidase, treating GM1 gangliosidosis, Morquio-B or Krabbe's disease, and treating Gaucher's disease, include administering a carba-sugar amine derivative represented by the following formula (1) or (2):
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: July 3, 2012
    Assignee: Seikagaku Corporation
    Inventors: Seiichiro Ogawa, Yoshiyuki Suzuki, Eiji Nanba, Junichiro Matsuda, Kousaku Ohno
  • Publication number: 20120161071
    Abstract: An acid gas absorbent of which recovery amount of acid gas such as carbon dioxide is high, and an acid gas removal device and an acid gas removal method using the acid gas absorbent are provided. The acid gas absorbent of the embodiment comprising at least one type of tertiary amine compound represented by the following general formula (1). (In the above-stated formula (1), either one of the R1, R2 represents a substituted or non-substituted alkyl group of which carbon number is 2 to 5, and the other one represents a substituted or non-substituted alkyl group of which carbon number is 1 to 5. The R3 represents a methyl group or an ethyl group, and the R4 represents a hydroxyalkyl group. The R1, R2 may either be the same or different, and they may be coupled to form a cyclic structure.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 28, 2012
    Inventors: Shinji MURAI, Yukishige Maezawa, Yasuhiro Kato, Takehiko Muramatsu, Satoshi Saito, Hiroko Watando, Naomi Shida, Reiko Yoshimura, Takashi Kuboki
  • Publication number: 20120129947
    Abstract: This invention relates to amino-alcohol analogues and uses thereof in the treatment of diseases and disorders such as cancer, neurodegenerative and metabolic diseases and genetic storage diseases.
    Type: Application
    Filed: August 3, 2010
    Publication date: May 24, 2012
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Arie Dagan, Claudia M. Barzilay, Amona A. Ali
  • Patent number: 8158827
    Abstract: Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds to prepare liposomes and other lipid aggregates suitable for transfection or delivery of compounds to target cells, either in vitro or in vivo. The compounds are preferably polycationic and preferably form highly stable complexes with various anionic macromolecules, particularly polyanions such as nucleic acids. These compounds have the property, when dispersed in water, of forming lipid aggregates which associate strongly, via their cationic portion, with polyanions. Also disclosed are intermediates for preparing the compound and compositions of the invention and methods of using the compounds to introduce other compounds into cells.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: April 17, 2012
    Assignee: Life Technologies Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Patent number: 8152903
    Abstract: Hindered cyclic polyamines and their salts are absorbents useful in acid gas treatment processes.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: April 10, 2012
    Assignee: ExxonMobile Research & Engineering Company
    Inventors: Michael Siskin, Alan R Katritzky, Edmund J. Mozeleski, Frank Cheng-Yu Wang
  • Publication number: 20120061613
    Abstract: A system, method, and material that enables the pressure-activated reversible chemical capture of acid gasses such as CO2 from gas volumes such as streams, flows or any other volume. Once the acid gas is chemically captured, the resulting product typically a zwitterionic salt, can be subjected to a reduced pressure whereupon the resulting product will release the captures acid gas and the capture material will be regenerated. The invention includes this process as well as the materials and systems for carrying out and enabling this process.
    Type: Application
    Filed: September 10, 2010
    Publication date: March 15, 2012
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: David J. Heldebrant, Phillip K. Koech, John C. Linehan, James E. Rainbolt, Mark D. Bearden, Feng Zheng
  • Publication number: 20120065433
    Abstract: A catalyst which comprises a carrier and silver deposited on the carrier, which carrier has a surface area of at least 1.3 m2/g, a median pore diameter of more than 0.8 ?m, and a pore size distribution wherein at least 80% of the total pore volume is contained in pores with diameters in the range of from 0.1 to 10 ?m and at least 80% of the pore volume contained in the pores with diameters in the range of from 0.1 to 10 ?m is contained in pores with diameters in the range of from 0.
    Type: Application
    Filed: November 18, 2011
    Publication date: March 15, 2012
    Applicant: SHELL OIL COMPANY
    Inventors: William Herman GERDES, John Robert LOCKEMEYER, Donald James REMUS, Thomas SZYMANSKI, Randall Clayton YEATES
  • Publication number: 20120046441
    Abstract: A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond; where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; and where part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.
    Type: Application
    Filed: August 26, 2011
    Publication date: February 23, 2012
    Inventors: Pierre Deslongchamps, Yves Dory, Gilles Berthiaume, Luc Ouellet, Ruoxi Lan
  • Publication number: 20120000118
    Abstract: A fuel additive composition comprising (A) polyisobutyl-based nitrogen-containing dispersants with MN of the polyisobutyl group of from 650 to 1800 Dalton, (B) carrier oils substantially free of nitrogen and (C) polyisobutyl-based dispersant boosters with MN of the polyisobutyl group of from 200 to 650 Dalton, with the proviso that the difference between the MN of the polyisobutyl group of component (A) and the MN of the polyisobutyl group of component (C) is more than 100 Dalton. Said component (C) is especially useful as an intake valve clean-up booster in gasoline-operated port fuel injection internal combustion engines.
    Type: Application
    Filed: June 1, 2011
    Publication date: January 5, 2012
    Applicant: BASF SE
    Inventors: Arno LANGE, Peter Schreyer, Robert Stuart Grace
  • Patent number: 8076434
    Abstract: The present invention has an object to provide an amphoteric polymer having high anti-soil redeposition ability and solubility with surfactants, and a process for producing the same. The amphoteric polymer includes: a structure unit (a) derived from a cationic group-containing monomer (A); and a structure unit (b) derived from a carboxyl group-containing monomer (B). The structure unit (a) is present at a level of 1 to 99% by mass based on 100% by mass of all structure units derived from all monomers in the amphoteric polymer, and the structure unit (b) is present at a level of 1 to 99% by mass based on 100% by mass of all the structure units derived from all the monomers in the amphoteric polymer.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: December 13, 2011
    Assignee: Nippon Shokubai Co., Ltd
    Inventors: Atsuro Yoneda, Daisuke Michitaka
  • Publication number: 20110288339
    Abstract: The present invention provides a reactor system comprising: —one or more purification zones comprising an absorbent which comprises silver, an alkali or alkaline earth metal, and a support material having a surface area of more than 20 m2/g, and —a reaction zone comprising a catalyst, which reaction zone is positioned downstream from the one or more purification zones; an absorbent; a process for reacting a feed comprising one or more feed components; and a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.
    Type: Application
    Filed: May 15, 2008
    Publication date: November 24, 2011
    Inventor: Marek Matusz
  • Publication number: 20110282081
    Abstract: Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, regioselective epoxide-opening, hydrogenation, and dihydroxylation. The methods described herein provide 1-deoxy-sphingoid bases and derivatives in high overall yield and high enantiomeric purity.
    Type: Application
    Filed: January 21, 2010
    Publication date: November 17, 2011
    Applicant: EMORY UNIVERSITY
    Inventors: Lanny S. Liebeskind, Ethel C. Garnier-Amblard, Dennis C. Liotta
  • Publication number: 20110251294
    Abstract: Low molecular weight gelators, methods of making such gelators, organogels comprising such gelators and methods of using such organogels are described. In exemplary methods, the gelators can be used in a variety of applications including the delivery of pharmaceutical active pharmaceutical ingredients, in food, cosmetics and consumer products, and in containing the unexpected release of chemical that occur for example in spills.
    Type: Application
    Filed: March 8, 2011
    Publication date: October 13, 2011
    Applicant: Georgetown University
    Inventors: Richard G. Weiss, Ajaya Mallia Viswanatha Mallya
  • Publication number: 20110229565
    Abstract: This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.
    Type: Application
    Filed: September 17, 2009
    Publication date: September 22, 2011
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, George John, Greg Cruikshank
  • Patent number: 7968530
    Abstract: Organic compounds are described, which are capable of forming quaternary salts, quaternary salts thereof with a structure having general formula (I) and their use for the control of phytopathogen fungi.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: June 28, 2011
    Assignee: Isagro S.p.A
    Inventors: Lucio Filippini, Marilena Gusmeroli, Silvia Mormile, Luigi Mirenna
  • Publication number: 20110152574
    Abstract: A new class of compounds, namely diamino alcohols, is described, along with a process for their production and their use as dispersing additives for coating formulations.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 23, 2011
    Inventors: Asghar A. Peera, Ian A. Tomlinson
  • Publication number: 20110107527
    Abstract: Method of cleaning a white load in a laundry machine, preferably a professional laundry machine, the method comprises subjecting the load to at least two washing steps and wherein the method comprises the steps of delivering bleach and subsequently a whitening additive.
    Type: Application
    Filed: November 1, 2010
    Publication date: May 12, 2011
    Inventors: Francesco DE Buzzaccarini, Rapheal Angeline Alfons Ceulemans, Edward Robert Offshack
  • Patent number: 7910078
    Abstract: The present invention relates to a method for removing carbon dioxide (CO2) from a gas stream. Particularly, the present invention relates to a method for removing CO2 from a gas stream by a liquid absorbent having an amino alcohol derived from 4-amino-2-butanol. In comparison to conventional amines, the amino alcohols of the present invention have been found to provide a higher CO2 absorption capacity and a higher cyclic capacity for CO2 removal.
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: March 22, 2011
    Assignee: University of Regina
    Inventors: Paitoon Tontiwachwuthikul, Andrew G. H. Wee, Raphael Idem, Kreangkrai Maneeintr, Gao-jun Fan, Amornvadee Veawab, Amr Henni, Adisorn Aroonwilas, Amit Chakma
  • Publication number: 20110065811
    Abstract: Ethanolamine glyceryl ether condensation products of the formula (I) are described, in which R1, R2 and R3 may each independently be the same or different and are each hydrogen, a linear or branched, saturated alkyl chain having from 1 to 20 carbon atoms, a linear or branched unsaturated alkenyl group having from 2 to 20 carbon atoms, —CH2—CH2—OH or a radical of the formula (II), with the proviso that at least one of the R1, R2 and R3 radicals is a radical of the formula (II) and at least one further radical of the R1, R2 and R3 radicals is selected from —CH2—CH2—OH and radicals of the formula (II), wherein (O-A), (O-D), R4, R5, a, b, d, and e are as defined in the specification.
    Type: Application
    Filed: March 15, 2007
    Publication date: March 17, 2011
    Applicant: CLARIANT INTERNATIONAL LTD.
    Inventors: Franz-Xaver Scherl, Joachim Hess, Ralf Zerrer, Christian Sowa
  • Publication number: 20110041736
    Abstract: A belite-calcium sulphoaluminate-ferrite (BCSAF) cement composition including: a BCSAF clinker which clinker has the following mineralogical composition, based on the total weight of the clinker: 5 to 25%, preferably 10 to 20%, of a calcium aluminoferrite phase having the general formula C2AxF(1?X), wherein X is from 0.2 to 0.8; 15 to 35% of a calcium sulphoaluminate phase; 40 to 75% of belite (C2S); from 0.01 to 10% in total of one or more minor phases selected from calcium sulphates, alkali metal sulphates, perovskite, calcium aluminates, gehlenite, free lime and periclase and/or a vitreous phase; and an alkanolamine.
    Type: Application
    Filed: March 24, 2009
    Publication date: February 24, 2011
    Applicant: LAFARGE
    Inventors: Ellis Gartner, Vincent Morin
  • Publication number: 20110034710
    Abstract: A catalyst for the epoxidation of an olefin comprising a carrier and, deposited on the carrier, silver, a rhenium promoter, a first co-promoter, and a second co-promoter; wherein the molar ratio of the first co-promoter to the second co-promoter is greater than 1; the first co-promoter is selected from sulfur, phosphorus, boron, and mixtures thereof; and the second co-promoter is selected from tungsten, molybdenum, chromium, and mixtures thereof; a process for preparing the catalyst; a process for preparing an olefin oxide by reacting a feed comprising an olefin and oxygen in the presence of the catalyst; and a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.
    Type: Application
    Filed: May 7, 2008
    Publication date: February 10, 2011
    Inventor: Marek Matusz
  • Publication number: 20110028732
    Abstract: Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.
    Type: Application
    Filed: April 8, 2009
    Publication date: February 3, 2011
    Applicants: ANGUS CHEMICAL COMPANY, GLOBAL TECHNOLOGIES INC.
    Inventors: Daniel M. Trauth, George D. Green, Raymond J. Swedo, Richard L. James, Ian A. Tomlinson
  • Patent number: 7871602
    Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: January 18, 2011
    Assignee: Alcon, Inc.
    Inventors: Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows
  • Publication number: 20100267963
    Abstract: The present invention provides a method of producing 2-alkyl-3-aminothiophene derivative represented by Formula (4), the method comprising oxidizing a compound represented by the following Formula (1) to produce a compound represented by the following Formula (3) and reducing the compound represented by the following Formula (3): wherein in Formula (1), Formula (3), and Formula (4), R represents an alkyl group, a cycloalkyl group, or a bicycloalkyl group; and X represents a hydroxyl group, a halogen atom acyloxy group, an alkylsulfonyl group, or an arylsulfonyl group.
    Type: Application
    Filed: April 16, 2010
    Publication date: October 21, 2010
    Applicant: MITSUI CHEMICALS AGRO, INC.
    Inventors: Yasuaki FUKAZAWA, Yoji Aoki, Haruko Mita, Hironori Komatsu
  • Publication number: 20100249463
    Abstract: An amine producing apparatus includes a reactor that reacts a mono-lower-alkylamine and an alkylene oxide, an unreacted-raw-material-recovery distillation column that separates unreacted raw materials by distillation from a product including unreacted raw materials obtained in the reactor, a non-aqueous distillation column that removes water and a light component by a distillation method from a reactive product from which unreacted raw material have been separated, and a purification and distillation column that separates by distillation a desired reactive product (mono-lower-alkylmonoalkanolamine) and residue (mono-lower-alkyldialkanolamine which is a dimer) from a reactive product from which the water and the light component have been removed.
    Type: Application
    Filed: August 6, 2007
    Publication date: September 30, 2010
    Applicants: MITSUBISHI HEAVY INDUSTRIES, LTD., NIPPON NYUKAZAI CO., LTD.
    Inventors: Shinya Tachibana, Ryuji Yoshiyama, Tsuyoshi Oishi, Mikiya Sakurai, Kazuo Ishida, Tatsuya Tsujiuchi, Hidehisa Mita, Ryosuke Araki, Kenji Saito
  • Publication number: 20100236140
    Abstract: The present invention relates to novel fuel additives obtainable by reacting carboxylic acids and alkanol amines under specific conditions. Said additives show an improved performance in fuels, like gasoline. The invention also relates to methods of preparing the same; additive packages containing said additives; and methods of improving the storage stability of additive packages comprising a detergent additive in an organic solvent.
    Type: Application
    Filed: October 17, 2008
    Publication date: September 23, 2010
    Applicant: BASF SE
    Inventors: Ludwig Voelkel, Dietmar Posselt, Alfred Karl Jung, Markus Kummeter, Gero Nordmann, Andrea Misske
  • Publication number: 20100240928
    Abstract: The invention relates to a process for the preparation of (S)-2-amino-1-propanol (L-alaminol) from (S)-1-methoxy-2-propylamine via the hydrochloride of (S)-2-amino-1-propanol and subsequent work-up.
    Type: Application
    Filed: December 10, 2008
    Publication date: September 23, 2010
    Applicant: BASF SE
    Inventors: Olaf Kutzki, Klaus Ditrich, Michael Bartsch
  • Patent number: 7799952
    Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: September 21, 2010
    Assignee: ratiopharm GmbH
    Inventors: Jiri Stohandl, Jaroslav Frantisek, Winfried Ness
  • Publication number: 20100183732
    Abstract: The present invention relates to a novel one step process for preparing cross-linked poly(allylamine) polymers or salts thereof using the novel cross-linking agent of Formula (IV). This invention also relates to the compound of Formula (IV) as well as to a process to obtain it. The cross-linked poly(allylamine) polymers of the invention are useful in medicine as substrate-binding polymers.
    Type: Application
    Filed: July 16, 2008
    Publication date: July 22, 2010
    Inventors: Sabrina Bianchi, Valter Castelvetro, Giovanni Marras, Sonja Bellomi, Graziano Castaldi, Gianpiero Ventimiglia
  • Publication number: 20100175826
    Abstract: The present invention relates to a binder for the production of bonded mineral wool, wherein a phenol-formaldehyde-binder is applied onto the still hot fibers after the fiberization of a mineral wool, using a binder that comprises hydroxylamine or an amino alcohol with the following general formula (I) wherein R1 and R2 are the same or different from each other, and independently are hydrogen, a linear or branched, saturated or unsaturated aliphatic hydrocarbon with 1-12 carbon atoms, a saturated or unsaturated alicyclic or heterocyclic hydrocarbon with 5-8 carbon atoms, a carbocyclic or heterocyclic aromatic hydrocarbon with 5-12 ring members or a chain-like or branched alkylether with 1-50 alkoxy units or a chain-like or branched alkylamine with 1-50 alkylamine units; and R3 is a linear or branched, saturated or unsaturated aliphatic hydrocarbon with 1-12 carbon atoms, a saturated or unsaturated alicyclic or heterocyclic hydrocarbon with 5-8 carbon atoms, a carbocyclic or heterocyclic aromatic hydrocarbon w
    Type: Application
    Filed: June 26, 2006
    Publication date: July 15, 2010
    Applicant: SAINT-GOBAIN ISOVER
    Inventors: Hagen Huenig, Eva Wagner
  • Patent number: 7737303
    Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluoro-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: June 15, 2010
    Assignee: Wyeth LLC
    Inventors: John Sellstedt, Gloria Cheal, Razzak Noureldin, Anita Wai-Yin Chan, Panolil Raveendranath, Thomas Joseph Caggiano
  • Publication number: 20100036170
    Abstract: Processes and systems for purifying ethylene oxide, including introducing a feed stream including ethylene oxide to a heat exchanger to heat the feed stream, feeding the heated feed stream to a distillation apparatus base below a first stage, removing from the distillation apparatus an impurity fraction as a top exit stream from the distillation apparatus located at a top take-off on the distillation apparatus, removing from the distillation apparatus an ethylene oxide stream of 99.7 weight percent purity, based on the total weight of the ethylene oxide stream, from the distillation apparatus, and removing from the distillation apparatus an aldehyde enriched fraction as a bottom stream from the distillation apparatus, where the aldehyde enriched fraction is fed directly to a glycol reactor.
    Type: Application
    Filed: July 24, 2009
    Publication date: February 11, 2010
    Inventors: Clarence P. Stadlwieser, Bernie B. Osborne, John P. Dever, Harvey E. Andresen, Michael L. Hutchision, Gary L. Culp, Donald Culp, Stephen R. Osborne, Liping Zhang, Michael Habenschuss, Andrew Addie
  • Patent number: 7638650
    Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a covalent bond, —O— or —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is an alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups; R is hydrogen or a C1 to C4 alkyl; and Ro1 is an aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens; provided that 1) when Y is —(CH2)nRf, Ro is Ro1; 2) when X is hydrogen, Y is —CH2CH(CF3)2; and 3) when X is —(CH2)nRf and Y is —(CH2)nRf, Ro is Ro1.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: December 29, 2009
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Weiming Qiu
  • Publication number: 20090318563
    Abstract: Certain ethanolamine analogs and related compounds useful in the control of nematodes that infest plants or the situs of plants are described.
    Type: Application
    Filed: December 23, 2008
    Publication date: December 24, 2009
    Inventors: Michelle Coutu Hresko, Deryck J. Williams, Merry B. McLaird, John D. Bradley, Barry J. Shortt, Ronald E. Worthington
  • Patent number: 7635791
    Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: December 22, 2009
    Assignee: TPAT IP LLC
    Inventor: Thomas Daly
  • Patent number: 7612079
    Abstract: The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof wherein R2 is 2-hydroxymethylpyrrolidin-1-yl, or NHCH(R4)CH(R3)OH, wherein R3 is hydrogen or methyl and R4 is methyl, ethyl or isopropyl; R6 is 3-nitrophenylamino, 3,4-dimethoxybenzylamino, 3-iodobenzyl-amino, pyrid-2-yl-methylamino, pyrid-4-yl-methylamino or indan-5-amino; R9 is isopropyl or cyclopentanyl. In a further aspect, the invention relates to pharmaceutical compositions comprising said compounds, and the use thereof in treating antiproliferative disorders and or viral disorders.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: November 3, 2009
    Assignees: Cyclacel Limited, Cancer Research Technology Limited
    Inventors: Peter Martin Fischer, Mike Jarman, Ted McDonald, Bernard Nutley, Florence Raynaud, Stuart Wilson, Paul Workman
  • Patent number: 7601872
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and w
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: October 13, 2009
    Assignee: Life Technologies Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Patent number: 7598422
    Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluor-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: October 6, 2009
    Assignee: Wyeth
    Inventors: John Sellstedt, Gloria Cheal, Razzak Noureldin, Anita Wai-Yin Chan, Panolil Raveendranath, Thomas Joseph Caggiano
  • Patent number: 7582642
    Abstract: The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: September 1, 2009
    Assignees: Cyclacel Limited, Cancer Research Technology Limited
    Inventors: Peter Martin Fischer, Michael Jarman, Edward McDonald, Bernard Nutley, Florence Raynaud, Stuart Wilson, Paul Workman
  • Patent number: 7566806
    Abstract: An alkylamino group-terminated fluoroether compound, represented by the following general formula: RfO[CF(CF3)CF2O]mCF(CF3)(CH2)nNR1R2 (where Rf is a perfluoro lower-alkyl group, R1 is an alkyl group having 1-12 carbon atoms, R2 is a hydrogen atom, or an alkyl group having 1-12 carbon atoms, m is an integer of 0-10, and n is an integer of 3-8) is a novel compound, and is produced by reaction of an iodide-terminated fluoroether compound, represented by the following general formula: RfO[CF(CF3)CF2O]mCF(CF3)(CH2)nI with an alkylamine compound, represented by the following general formula: NHR1R2.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: July 28, 2009
    Assignee: Unimate Co., Ltd.
    Inventors: Keisuke Kokin, Takehiro Sonoi, Kimihiko Urata
  • Publication number: 20090149677
    Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.
    Type: Application
    Filed: February 10, 2009
    Publication date: June 11, 2009
    Applicant: ratiopharm GmbH
    Inventors: Jiri Stohandl, Jaroslav Frantisek, Winfried Ness
  • Patent number: 7544689
    Abstract: The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or un branched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: June 9, 2009
    Assignees: Cyclacel Limited, Cancer Research Technology Limited
    Inventors: Peter Martin Fischer, Michael Jarman, Edward McDonald, Bernard Nutley, Florence Raynaud, Stuart Wilson, Paul Workman
  • Publication number: 20090143544
    Abstract: Integrated processes of preparing industrial chemicals starting from seed oil feedstock compositions containing one or more unsaturated fatty acids or unsaturated fatty acid esters, which are essentially free of metathesis catalyst poisons, particularly hydroperoxides; metathesis of the feedstock composition with a lower olefin, such as ethylene, to form a reduced chain olefin, preferably, a reduced chain ?-olefin, and a reduced chain unsaturated acid or ester, preferably, a reduced chain ?,?-unsaturated acid or ester. The reduced chain unsaturated acid or ester may be (trans)esterified to form a polyester polyolefin, which may be epoxidized to form a polyester polyepoxide. The reduced chain unsaturated acid or ester may be hydroformylated with reduction to produce an ?,?-hydroxy acid or ?,?-hydroxy ester, which may be (trans)esterified with a polyol to form an ?,?polyester polyol.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 4, 2009
    Applicant: Dow Global Technologies Inc.
    Inventors: Zenon Lysenko, Bob R. Maughon, Jozef Bicerano, Kenneth A. Burdett, Christopher P. Christenson, Clark H. Cummins, Marvin L. Dettloff, Alan K. Schrock, P. J. Thomas, Richard D. Varjian, Jerry E. White, John Michael Maher
  • Publication number: 20090130020
    Abstract: This invention relates to novel compounds F-18 radio-labeled amino-alcohols suitable for labeling or already labeled by 18F methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
    Type: Application
    Filed: September 11, 2008
    Publication date: May 21, 2009
    Inventors: Lutz Lehmann, Mathias Berndt, Dietmar Berndorff, Sabine Zitzmann-Kolbe, Ulrike Bauder-Wust, Martin Schafer, Uwe Haberkorn, Michael Eisenhut, Armin Runz
  • Patent number: 7531693
    Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: May 12, 2009
    Assignee: Molecular Transfer, Inc.
    Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
  • Patent number: 7524887
    Abstract: The present invention relates to a method for the prophylaxis or treatment of pain using compounds of formula I, in which R, R2, R3, R4 and R5 have the meanings indicated in the specification.
    Type: Grant
    Filed: May 25, 2004
    Date of Patent: April 28, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Martin Michaelis, Gerd Geisslinger, Klaus Scholich
  • Publication number: 20090068168
    Abstract: Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 3, 2008
    Publication date: March 12, 2009
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Patent number: 7495131
    Abstract: Tertiary amines useful as catalysts for preparing polyurethane foams are provided. Tertiary amines are employed to catalyze the trimerization reaction of isocyanates and the reaction between isocyanates and active hydrogen-containing compounds, such as a polyol and/or a blowing agent. Such tertiary amine has the general formula wherein R1, R2, Y, Z, and n are defined herein.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: February 24, 2009
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Juan Jesus Burdeniuc, Ann Zdancewic Kamzelski
  • Publication number: 20090029948
    Abstract: Organic compounds are described, which are capable of forming quaternary salts, quaternary salts thereof with a structure having general formula (I) and their use for the control of phytopathogen fungi.
    Type: Application
    Filed: December 15, 2006
    Publication date: January 29, 2009
    Applicant: ISAGRO S.p.A.
    Inventors: Lucio Filippini, Marilena Gusmeroli, Silvia Mormile, Luigi Mirenna
  • Patent number: 7470817
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)I, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and w
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 30, 2008
    Assignee: Invitrogen Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu