Polyether Patents (Class 564/504)
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Publication number: 20120071622Abstract: A method for providing a secondary or tertiary amine with formula (R1R2NR3)2NR4 is provided, wherein each of R1 and R2 are chosen from the group consisting of a methyl group, an ethyl group, an iso-propyl group and an n-propyl group; R3 being an alkoxyalkyl group chosen from the group consisting of —CH2CH2OCH2CH2-, —CH2CH2OCH2CH2CH2- and —CH2CH2CH2OCH2CH2CH2-; R4 is chosen from the group consisting of a hydrogen, a methyl group, an ethyl group, an iso-propyl group, an n-propyl group and a group with formula R1R2NR3.Type: ApplicationFiled: May 6, 2010Publication date: March 22, 2012Applicants: Huntsman Corporation Hungary ZRt, Huntsman International LLCInventors: Zsolt Gaspar, Heiko H. Humbert, Gabor Felber, Attila Gaspar, Robert A. Grigsby, JR., Imre Kordas, Petra Emma Vanderstraeten
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Patent number: 8080690Abstract: The invention relates to a compound of the following formula (I) X—CR1R2R3 wherein —R1 is an organic moiety having 6 to 24 carbon atoms; —R2 is H or an organic moiety having 6 to 24 carbon atoms; —R3 is X or OH; —X is a moiety of the following formula (II): or an ammonium or C1-C4 alkyl ammonium salt of the moiety of formula (II); wherein -x is 0 or 1; -y is 0 or 1; -z is 0 or 1; -m is a number from 2 to 10; -n is a number from 0 to 10; -o is a number from 0 to 10; —R4 is H or a C1-C4 alkyl group; —R5 is a C6-C22 alkyl or alkenyl group or, if n or o is at least 1, a C7-C23 acyl group; —R6 is H or R5; —R7 is a C1-C4 alkylene group. which is capable of delivering aldehyde-type or ketone-type fragrance compounds, providing a long-lasting release of said fragrance compounds. This compound can be incorporated into fiber conditioning compositions, such as hair conditioners and fabric softeners, to enhance the fragrance performance.Type: GrantFiled: March 29, 2007Date of Patent: December 20, 2011Assignee: Kao Corporation S.A.Inventors: Maria José Bermejo Osés, Marc Arderiu Girame, Hiroshi Abe
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Patent number: 8076434Abstract: The present invention has an object to provide an amphoteric polymer having high anti-soil redeposition ability and solubility with surfactants, and a process for producing the same. The amphoteric polymer includes: a structure unit (a) derived from a cationic group-containing monomer (A); and a structure unit (b) derived from a carboxyl group-containing monomer (B). The structure unit (a) is present at a level of 1 to 99% by mass based on 100% by mass of all structure units derived from all monomers in the amphoteric polymer, and the structure unit (b) is present at a level of 1 to 99% by mass based on 100% by mass of all the structure units derived from all the monomers in the amphoteric polymer.Type: GrantFiled: December 22, 2010Date of Patent: December 13, 2011Assignee: Nippon Shokubai Co., LtdInventors: Atsuro Yoneda, Daisuke Michitaka
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Publication number: 20110293703Abstract: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: ApplicationFiled: November 6, 2009Publication date: December 1, 2011Applicant: Massachusetts Institute of TechnologyInventors: Kerry Peter Mahon, Kevin Thomas Love, Christopher G. Levins, Kathryn Ann Whitehead, Robert S. Langer, Daniel Griffith Anderson
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Publication number: 20110262527Abstract: The present invention provides compositions comprising cationic lipids, liposomes and nucleic acid-lipid particles comprising the cationic lipids, and methods of using such compositions, liposomes, and nucleic acid-lipid particles.Type: ApplicationFiled: June 8, 2010Publication date: October 27, 2011Applicant: Protiva Biotherapeutics, Inc.Inventors: James Heyes, Ian MacLachlan, Lorne R. Palmer
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Publication number: 20110142952Abstract: This invention relates to crosslinked amine-containing polymers for binding compounds or ions, and more specifically relates to pharmaceutically acceptable compositions for binding compounds or ions that include crosslinked amine-containing polymers. The pharmaceutically acceptable composition includes, for example, crosslinked polyamine particles, or pharmaceutically acceptable salts thereof, having a particle size distribution wherein greater than 10 vol. % of the particles have a particle size greater than 500 ?m.Type: ApplicationFiled: June 17, 2009Publication date: June 16, 2011Inventors: David J. Harris, Stephen Randall Holmes-Farley, Steven C. Polomoscanlk, Adnan Salameh, Bruce Shutts, Richard Silva
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Publication number: 20110137061Abstract: A nanoink composition for forming an absorber layer of a thin film solar cell comprises particles and a volatile chelating agent mixing with the particles. The particles contain one or more elements selected from group IB and/or IIIA and/or VIA. In the present invention, the volatile chelating agent is a polyetheramine which can alternatively be monoamine compounds, diamine compounds and triamine compounds and has a molecular weight of from about 100 to about 4,000. Accordingly, the particles can be reacted mutually into a single composition while the existence of the volatile chelating agent.Type: ApplicationFiled: December 9, 2009Publication date: June 9, 2011Inventor: Chi-Jie Wang
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Publication number: 20110124880Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.Type: ApplicationFiled: January 13, 2011Publication date: May 26, 2011Applicant: Ambrx, Inc.Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
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Patent number: 7871602Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.Type: GrantFiled: October 3, 2008Date of Patent: January 18, 2011Assignee: Alcon, Inc.Inventors: Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows
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Patent number: 7851655Abstract: A composition and method for inhibiting white rust formation on galvanized surfaces. The composition includes hydroxyl-substituted monoamines and polyamines, imino derivatives, and hydroxyamine derivatives. The composition may be introduced onto the galvanized surface, especially in an industrial water system, using a variety of different methods or programs including integrating with current programs or developing a new program.Type: GrantFiled: December 19, 2006Date of Patent: December 14, 2010Assignee: Nalco CompanyInventor: Srikanth S. Kidambi
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Publication number: 20100267963Abstract: The present invention provides a method of producing 2-alkyl-3-aminothiophene derivative represented by Formula (4), the method comprising oxidizing a compound represented by the following Formula (1) to produce a compound represented by the following Formula (3) and reducing the compound represented by the following Formula (3): wherein in Formula (1), Formula (3), and Formula (4), R represents an alkyl group, a cycloalkyl group, or a bicycloalkyl group; and X represents a hydroxyl group, a halogen atom acyloxy group, an alkylsulfonyl group, or an arylsulfonyl group.Type: ApplicationFiled: April 16, 2010Publication date: October 21, 2010Applicant: MITSUI CHEMICALS AGRO, INC.Inventors: Yasuaki FUKAZAWA, Yoji Aoki, Haruko Mita, Hironori Komatsu
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Publication number: 20100104629Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.Type: ApplicationFiled: September 10, 2009Publication date: April 29, 2010Applicant: ABBOTT LABORATORIESInventors: Prasad A. Dande, Todd M. Hansen, Robert D. Hubbard, Aparna V. Sarthy, Yu Shen, Lu Tian, Carol K. Wada, Xiaobin Zhao
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Patent number: 7648651Abstract: A solvent composition contains a tetralin compound (a) represented by the formula (I) and a polyether compound (b) represented by the formula (II). The solvent composition is excellent in safety and almost odorless, having a high capability of dissolving various organic materials, and also excellent in affinity to various substrates. The solvent composition is suitably used for various applications including various kinds of paints, adhesives, coating materials, detergents, and the like.Type: GrantFiled: April 18, 2006Date of Patent: January 19, 2010Assignee: Adeka CorporationInventors: Mitsuo Akutsu, Takahiro Otsuka
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Publication number: 20100010194Abstract: Provided herein is a straightforward and efficient method for covalently attaching a polyethylene glycol polymer to an active agent.Type: ApplicationFiled: November 30, 2007Publication date: January 14, 2010Inventor: Wen Zhang
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Patent number: 7638650Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a covalent bond, —O— or —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is an alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups; R is hydrogen or a C1 to C4 alkyl; and Ro1 is an aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens; provided that 1) when Y is —(CH2)nRf, Ro is Ro1; 2) when X is hydrogen, Y is —CH2CH(CF3)2; and 3) when X is —(CH2)nRf and Y is —(CH2)nRf, Ro is Ro1.Type: GrantFiled: August 6, 2007Date of Patent: December 29, 2009Assignee: E.I. du Pont de Nemours and CompanyInventor: Weiming Qiu
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Publication number: 20090306391Abstract: The invention relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by contacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal-silica gel material in the presence of a solid proton source under conditions sufficient to form the corresponding amine. The invention also relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by a) reacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal-silica gel material, and b) subsequently reacting the reaction product from step a) with an electrophile or a proton source. Preferred Stage 0 or Stage I alkali metal-silica gel materials include Na, K2Na, and Na2K.Type: ApplicationFiled: February 13, 2007Publication date: December 10, 2009Applicant: SIGNA CHEMISTRY, LLCInventors: Michael Lefenfeld, James L. Dye, Partha Nandi, James Jackson
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Publication number: 20090263407Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.Type: ApplicationFiled: April 16, 2009Publication date: October 22, 2009Applicant: ABBOTT LABORATORIESInventors: Prasad A. Dande, Todd M. Hansen, Robert D. Hubbard, Carol K. Wada, Lu Tian, Xiaobin Zhao
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Patent number: 7601872Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: January 21, 2005Date of Patent: October 13, 2009Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Publication number: 20090198035Abstract: Provided herein are polyamine precursors useful in the manufacture of epoxy resins. Use of a polyamine precursor according to the invention provides an epoxy resin formulation having an increased working time over prior art amines used for curing epoxies. Increased working times translate to the ability to manufacture composites which could not be made using conventional epoxy curing agents, such as composite blades for wind-driven turbines. Such polyamines are also useful in polyurea formulations for lengthening reaction time, thus allowing more flow of applied polyurea coatings prior to gellation.Type: ApplicationFiled: April 9, 2009Publication date: August 6, 2009Applicant: Huntsman Petrochemical CorporationInventors: Howard P. Klein, Bruce L. Burton, Matthew W. Forkner, David C. Alexander, Terry L. Renken, Chris E. Godinich
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Patent number: 7566806Abstract: An alkylamino group-terminated fluoroether compound, represented by the following general formula: RfO[CF(CF3)CF2O]mCF(CF3)(CH2)nNR1R2 (where Rf is a perfluoro lower-alkyl group, R1 is an alkyl group having 1-12 carbon atoms, R2 is a hydrogen atom, or an alkyl group having 1-12 carbon atoms, m is an integer of 0-10, and n is an integer of 3-8) is a novel compound, and is produced by reaction of an iodide-terminated fluoroether compound, represented by the following general formula: RfO[CF(CF3)CF2O]mCF(CF3)(CH2)nI with an alkylamine compound, represented by the following general formula: NHR1R2.Type: GrantFiled: August 9, 2006Date of Patent: July 28, 2009Assignee: Unimate Co., Ltd.Inventors: Keisuke Kokin, Takehiro Sonoi, Kimihiko Urata
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Publication number: 20090130020Abstract: This invention relates to novel compounds F-18 radio-labeled amino-alcohols suitable for labeling or already labeled by 18F methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).Type: ApplicationFiled: September 11, 2008Publication date: May 21, 2009Inventors: Lutz Lehmann, Mathias Berndt, Dietmar Berndorff, Sabine Zitzmann-Kolbe, Ulrike Bauder-Wust, Martin Schafer, Uwe Haberkorn, Michael Eisenhut, Armin Runz
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Patent number: 7531693Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.Type: GrantFiled: May 24, 2004Date of Patent: May 12, 2009Assignee: Molecular Transfer, Inc.Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
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Publication number: 20090114879Abstract: The present invention relates to the use of a specific group of alkoxylated and/or acylated non-quaternary nitrogen-containing compounds as anti-agglomerants for gas hydrates. The anti-agglomerants are surface-active non-quaternary nitrogen-containing compounds with 1-5 nitrogen atoms, which compounds have at least one hydrophobic group with 6-24 carbon atoms, and where the hydrophobic group is connected to the remainder of the molecule by an amine moiety, an ether moiety or an amide moiety, provided that when the hydrophobic group is connected by means of an amide moiety to the remainder of the molecule, the compounds must contain a total of at least two nitrogen atoms, and optionally contain 1-12 —CH2CH2O— groups and/or 1-6 hydroxyalkyl groups with 3-4 carbon atoms; and which compounds have at least one C2-C3 acyl group and/or at least one hydroxyalkyl group with 3-4 carbon atoms; or a salt thereof.Type: ApplicationFiled: March 16, 2007Publication date: May 7, 2009Applicant: AKZO NOBEL N.V.Inventors: Martin Hellsten, Hans Oskarsson
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Patent number: 7470817Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)I, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: December 28, 2006Date of Patent: December 30, 2008Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7445771Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.Type: GrantFiled: December 9, 2004Date of Patent: November 4, 2008Assignee: Alcon, Inc.Inventors: Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows
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Publication number: 20080207913Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.Type: ApplicationFiled: April 27, 2007Publication date: August 28, 2008Applicant: Intezyne TechnologiesInventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
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Patent number: 7387768Abstract: The invention relates to the use of an absorption liquid for purifying gases from gaseous acidic contaminants, the absorption liquid comprising A) 0.1 to 100% by weight of one or more amines of the formula I where R1 is H, C1-C6-alkyl, an aromatic radical having 6 to 18 carbon atoms or a radical of the formula 2 R2 is H, C1-C6-alkyl, an aromatic radical having 6 to 18 carbon atoms or a radical of the formula 3 R3 is C1-C6-alkyl or an aromatic radical having 6 to 18 carbon atoms R4 is H or CH3 R5 is H or CH3 x is a number from 0 to 3 y is a number from 0 to 3 z is an integer between 1 and 30, and also, if appropriate, B) 0 to 99.9% by weight of water, and/or C) 0 to 99.9% by weight of any desired solvent.Type: GrantFiled: September 1, 2005Date of Patent: June 17, 2008Assignee: Clariant Produkte (Deutschland) GmbHInventors: Horst Streitberger, Oliver Pfueller, Achim Stankowiak, Alexander Snell, Norbert Mollekopf, Hans-Dieter Mueller
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Patent number: 7323594Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by -X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: December 28, 2006Date of Patent: January 29, 2008Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7166745Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)1, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —CH2)p—D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: November 12, 1999Date of Patent: January 23, 2007Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7144978Abstract: Multi-armed functional polyethylene glycol polymers with active terminal groups may be used in conjugation with small molecule pharmaceuticals, proteins and peptides to enhance half-life and bioavailability of the drug and improve solubility, stability and immunological competence.Type: GrantFiled: July 15, 2004Date of Patent: December 5, 2006Assignee: Pan Asia Bio Co., Ltd.Inventors: Junlian Huang, Michael Min Xu, Xiaojian Hu, Yuhong Xu
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Patent number: 7145039Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: January 21, 2005Date of Patent: December 5, 2006Assignee: Invitrogen Corp.Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7060731Abstract: This application relates to the use of certain amines of formula (I) for combatting and preventing systemic and local complement activation, and in particular to the use of meglumine and derivatives and optionally salts thereof in combatting and preventing said activation. The amines are also of use in combatting activation of the kinin/kallikrein system or blood coagulation system.Type: GrantFiled: September 12, 2002Date of Patent: June 13, 2006Assignee: Amersham Health ASInventors: Anne Juelsrud, Gunn Ragnhild Hoigaard Bjerke
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Patent number: 7012043Abstract: Drilling fluid additives that act to control clay swelling in drilled formations without adversely effecting the properties of the drilling fluid. The drilling fluid additives preferably comprise a polyether amine, a polyether amine derivative, or mixtures thereof. Drilling fluids that comprise such drilling fluid additives and a method of reducing clay swelling in drilled formations are also disclosed.Type: GrantFiled: November 7, 2002Date of Patent: March 14, 2006Assignee: Huntsman Petrochemical CorporationInventors: Howard P. Klein, Chris E. Godinich
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Patent number: 6951686Abstract: A concrete article comprised of concrete having therein a reinforcing polymer that has a surface comprised of a thermoplastic hydroxy-functionalized polyether or polyester. The concrete article is made by mixing concrete, water and a reinforcing polymer that has a surface comprised of a thermoplastic hydroxy-functionalized polyether or polyester and curing said concrete mixture forming the concrete article.Type: GrantFiled: February 19, 2003Date of Patent: October 4, 2005Assignee: Dow Global Technologies Inc.Inventors: Aleksander J. Pyzik, Kenneth B. Stewart, Jr., John M. Beckerdite, Hari P. Reddy, Uday V. Deshmukh, Ted A. Morgan, Sharon M. Allen, Kwanho Yang, Nicholas M. Shinkel, David F. Pawlowski
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Patent number: 6916948Abstract: Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in particular dendrimers. Some of the derivatives may be useful as non-ionic surfactants.Type: GrantFiled: September 12, 2001Date of Patent: July 12, 2005Assignee: Isis Innovation LimitedInventors: George W. J. Fleet, David Scott, Malcolm Finn, Thomas Krūlle
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Patent number: 6747149Abstract: N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combination of such other agents.Type: GrantFiled: December 17, 2002Date of Patent: June 8, 2004Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis
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Patent number: 6583182Abstract: This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, results in decrease in the in vivo bioavailability of first transition series elements and/or removal from the body of first transition series elements and elements with similar chemical properties. These characteristics make such compounds useful in the management of diseases associated with a bodily excess of first transition series elements and elements with similar chemical properties. This invention demonstrates that such compounds inhibit mammalian, bacterial, and fungal cell replication and are therefore useful in the treatment of neoplasia, infection, inflammation, immune reponse, and in termination of pregnancy.Type: GrantFiled: November 30, 2001Date of Patent: June 24, 2003Assignee: Chelator LLCInventors: Harry S Winchell, Joseph Y Klein, Elliot D Simhon, Rosa L Cyjon, Ofer Klein, Haim Zaklad
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Patent number: 6583246Abstract: The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.Type: GrantFiled: November 6, 2001Date of Patent: June 24, 2003Assignee: Bayer AktiengesellschaftInventors: Michael Grün, Thomas Knauf, Wilfried Braubach
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Publication number: 20030045586Abstract: This application relates to the use of certain amines of formula (I) 1Type: ApplicationFiled: September 12, 2002Publication date: March 6, 2003Inventors: Anne Juelsrud, Gunn Ragnhild Hoigaard Bjerke
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Patent number: 6525221Abstract: A fuel oil detergent which efficiently constricts precipitate formation and octane number requirement increase in a carburetor, injector, and inlet system of an internal combustion engine, i.e., a hydropoly(oxyalkylene) oxyalkyl amine based compound, a process for preparing the compound, and a fuel oil composition including the compound.Type: GrantFiled: November 21, 2001Date of Patent: February 25, 2003Assignee: Daelim Industrial Co., Ltd.Inventors: Hyun-Ki Youn, Myeong-Seok Kim, Byung-Keel Sohn, Jae-Hoon Uhm, Byeong-Gyu Lim
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Patent number: 6492560Abstract: The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.Type: GrantFiled: September 24, 2001Date of Patent: December 10, 2002Assignee: The University of WashingtonInventors: D. Scott Wilbur, Pradip M. Pathare
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Patent number: 6492559Abstract: This invention provides water-based compositions, particularly coating, ink, and agricultural compositions, manifesting reduced equilibrium and dynamic surface tension by the incorporation of a surface tension reducing amount of certain alkylated aminoether compounds of the structure R—HN(CH2)p[O(CH2)n]mO(CH2)qNH—R′ where n is 2-6, m is 0-4, and p and q are 2-6, and R and R′ independently are an alkyl group comprising 5 to 18 carbons, preferably which is branched or in which the point of attachment to nitrogen is on a nonterminal carbon.Type: GrantFiled: January 4, 2000Date of Patent: December 10, 2002Assignee: Air Products and Chemicals, Inc.Inventors: Kevin Rodney Lassila, Kristen Elaine Minnich, Richard Van Court Carr
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Patent number: 6458999Abstract: The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.Type: GrantFiled: November 27, 2000Date of Patent: October 1, 2002Assignee: Nova Molecular Technologies INCInventors: Thomas J. Daly, Michael Clumpner, Anthony J. O'Lenick, Jr.
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Patent number: 6458837Abstract: The invention discloses stable diesters of chelating agents of divalent metal ions, processes for their preparation and pharmaceutical compositions thereof. Most preferred compounds according to the present invention are stable lipophilic diesters comprising a covalent conjugate of a BAPTA and a pharmaceutically acceptable alcohol. The diesters are useful in a method for treating a condition or disease related to an excess of divalent metal ions, and in particular for the treatment of a condition or disease related to elevated levels of intracellular calcium ions, such as in brain or cardiac ischemia, stroke, epilepsy, Alzheimer's disease or cardiac arrhythmia and in open heart surgery.Type: GrantFiled: March 27, 2000Date of Patent: October 1, 2002Assignee: D-Pharm Ltd.Inventors: Alexander Kozak, Israel Shapiro
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Poly(hydroxy amino ether) composition, method for preparing the same and articles prepared therefrom
Patent number: 6455116Abstract: A composition comprising a poly(hydroxy aminoether) and an effective amount of a propoxylated or ethoxylated phenol, process for preparing the same and articles prepared from the composition.Type: GrantFiled: September 14, 2001Date of Patent: September 24, 2002Assignee: Dow Global Technologies Inc.Inventors: Guang-Ming Xia, John M. Beckerdite, Wendy D. Hoenig -
Publication number: 20020082370Abstract: The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.Type: ApplicationFiled: November 6, 2001Publication date: June 27, 2002Inventors: Michael Grun, Thomas Knauf, Wilfried Braubach
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Patent number: 6294697Abstract: The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.Type: GrantFiled: April 17, 1998Date of Patent: September 25, 2001Assignee: The University of WashingtonInventors: D. Scott Wilbur, Pradip M. Pathare
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Patent number: 6251950Abstract: The present invention relates to the use of a group of propargylamines of the general formula (I) wherein R1 is hydrogen or CH3 and R2 is (CH2)nCH3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula I are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.Type: GrantFiled: July 6, 1998Date of Patent: June 26, 2001Assignee: University of SaskatchewanInventors: David Durden, Alick Paterson, Bruce Davis, Lillian Dyck, Peter Yu, Xinmin Li, Alan Boulton
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Patent number: 6114585Abstract: The present invention relates to a series of novel ether amine compounds prepared by the cyanobutylation reaction of an alcohol having 12 to 26 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and hydrogenated to yield a polyamine.Type: GrantFiled: December 13, 1999Date of Patent: September 5, 2000Assignee: Nova Molecular Technologies IncInventors: Thomas J. Daly, Anita Mokadam Sorhaug, Robert E. Harbour, Jr., Abraham A. Zahand, Michael Clumpner, Anthony J. O'Lenick, Jr.
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Patent number: 6060625Abstract: A process for the alkoxylation of a polyetheramine to form an etheramine alkoxylate. In the process, a polyetheramine is reacted with an alkylene oxide in the presence of an alcohol to form the etheramine alkoxylate. The alcohol serves as a catalyst to allow the reaction proceed at a heightened temperature as compared to the reaction in the absence of alcohol, while at the same time limiting the amount of glycol by-product production which would otherwise typically form when higher polyetheramines are to be alkoxylated. The alcohol may be, for instance, ethanol or methanol.Type: GrantFiled: April 30, 1999Date of Patent: May 9, 2000Assignee: Huntsman Petrochemical CorporationInventors: Wei-Yang Su, Mike W. McKinney, Timothy L. Lambert, Edward T. Marquis