Carbon To Carbon Unsaturation Containing Patents (Class 564/509)
-
Patent number: 4670470Abstract: Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K.sub.cat type.Type: GrantFiled: August 29, 1985Date of Patent: June 2, 1987Assignee: Merck & Co., Inc.Inventor: Raymond A. Firestone
-
Patent number: 4658062Abstract: Novel amine terminated polybutadiene compounds of the formula: ##STR1## wherein R is hydrogen, a straight or branched chain alkyl group containing from 1 to 10 carbon atoms or a substituted or unsubstituted aryl or aralkyl group containing one or more benzenoid rings which may be fused or joined by single valency bonds, and n is an integer of from about 5 to 1500 and a process for the preparation thereof.Type: GrantFiled: June 24, 1985Date of Patent: April 14, 1987Assignee: Atlantic Richfield CompanyInventors: Harry R. Hinney, Jamil Baghdadchi
-
Patent number: 4658066Abstract: Novel diamines of the formula ##STR1## are described, in which R.sub.1 is C.sub.1-12 -alkyl, R.sub.2 is H or C.sub.1-12 -alkyl, R.sub.3 is C.sub.1-12 -alkyl, cycloalkyl having 4-12 ring C atoms, C.sub.7-8 -aralkyl, substituted or unsubstituted aryl or, if R.sub.4 =H, is also --CH.dbd.CH--alkyl or --C(alkyl).dbd.CH-- alkyl each having 1-4 C atoms in the alkyl groups, and R.sub.4 is H, C.sub.1-12 -alkyl, cycloalkyl having 4-12 ring C atoms, C.sub.7-8 -aralkyl or substituted or unsubstituted aryl, or R.sub.1 and R.sub.2 and/or R.sub.3 and R.sub.4 together are C.sub.3-11 -alkylene. The diamines (I) are valuable intermediates and are suitable especially for the preparation of transparent crosslinkable polyamides.Type: GrantFiled: August 7, 1985Date of Patent: April 14, 1987Assignee: Ciba-Geigy CorporationInventors: Dieter Reinehr, Josef Pfeifer
-
Patent number: 4650907Abstract: Novel nonaromatic fluoroallylamines are potent MAO inhibitors and at low dose selectively inhibit MAO-B. They are useful in the treatment of depression and coadministered with L-dopa, in the treatment of Parkinsonism.Type: GrantFiled: December 5, 1985Date of Patent: March 17, 1987Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Philippe Bey, Michael G. Palfreyman, Ian A. McDonald
-
Patent number: 4645862Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.3 each is benzyl or substituted with up to 3 methoxy groups, R.sub.2 is a hydrogen atom and (alkylene) is lower alkyl and the compounds are useful for controlling viral infections.Type: GrantFiled: April 15, 1985Date of Patent: February 24, 1987Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
-
Patent number: 4612397Abstract: This invention is directed to thermally activated pelletted catalyst compositions comprising titania having phosphorous derived from a diaminohydrogen phosphate deposited thereon and to their preparation and their use in the production of predominantly linear polyethylenepolyamines from ethylenediamine and monoethanolamine.Type: GrantFiled: April 25, 1985Date of Patent: September 16, 1986Assignee: Texaco, Inc.Inventor: Terry L. Renken
-
Patent number: 4609761Abstract: This invention is directed to pelletted thermally activated catalyst compositions comprising titania having phosphorous derived from a trialkyl phosphate or phosphite deposited thereon and to their use in the production of predominantly linear polyethylenepolyamines from ethylenediamine and monoethanolamine.Type: GrantFiled: April 16, 1985Date of Patent: September 2, 1986Assignee: Texaco Inc.Inventors: Lewis W. Watts, Jr., Steven H. Vanderpool
-
Patent number: 4605797Abstract: Selective hydrogenation process is provided employing as catalyst a composition consisting essentially of elemental palladium on calcium carbonate support with lead acetate and an aromatic amine oxide. Very high selectivities to cis-olefinic compounds from acetylenic compounds is achieved employing the catalyst of the invention.Type: GrantFiled: December 20, 1984Date of Patent: August 12, 1986Assignee: Phillips Petroleum CompanyInventor: Charles A. Drake
-
Patent number: 4588842Abstract: This invention is directed to thermally activated pelletted catalyst compositions comprising phosphorous compounds deposited on group IVb transition metal oxides and their use in the production of predominately linear polyethylenepolyamines from ethylenediamine and monoethanolamine.Type: GrantFiled: December 22, 1983Date of Patent: May 13, 1986Assignee: Texaco Inc.Inventor: Steven H. Vanderpool
-
Patent number: 4584406Abstract: This invention is directed to pelletted catalyst compositions supported on group IVb transition metal oxides that contain phosphorous derived from phosphoryl chloride or phosphorous bromide and their use in the production of predominantly linear polyethylenepolyamines from ethylenediamine and monoethanolamine.Type: GrantFiled: December 6, 1984Date of Patent: April 22, 1986Assignee: Texaco Inc.Inventors: Steven H. Vanderpool, Terry L. Renken
-
Patent number: 4578519Abstract: This invention is directed to thermally activated pelletted catalyst compositions comprising titania having phosphorous derived from polyphosphoric acid deposited thereon and to their use in the production of predominatly linear polyethylenepolyamines from ethylenediamine and monoethanolamine.Type: GrantFiled: December 22, 1983Date of Patent: March 25, 1986Assignee: Texaco Inc. (Parent)Inventors: John M. Larken, Steven H. Vanderpool
-
Patent number: 4578518Abstract: This invention is directed to thermally activated pelletted calcined catalyst compositions comprising titania having phosphorous derived from phosphoric acid deposited thereon and their use in the production of predominatly linear polyethylenepolyamines from ethylenediamine and monoethanolamine.Type: GrantFiled: December 22, 1983Date of Patent: March 25, 1986Assignee: Texaco Inc.Inventors: Steven H. Vanderpool, Lewis W. Watts, Jr.
-
Patent number: 4568765Abstract: This invention relates to new isoprenylamine derivatives and acid addition salts thereof, which are useful as medicines for controlling virus infection of vertebrate animals, or the intermediates therefor.Type: GrantFiled: May 12, 1982Date of Patent: February 4, 1986Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
-
Patent number: 4564477Abstract: There are provided polyprenyl compounds of the formula ##STR1## wherein ##STR2## represent a trans-isoprene unit and a cis-isoprene unit, respectively, n is an integer of 11-19, Z.sup.1 and Z.sup.2 combinedly represent .dbd.O, .dbd.CH--COOH,.dbd.CH--COOR.sup.1, .dbd.CH--CN, .dbd.C(CN)COOR.sup.2, .dbd.CH--CO--NH.sub.2, .dbd.CH--CO--N(R.sup.3) (R.sup.4), .dbd.CH--CO--NHR.sup.5, .dbd.CH--CH.sub.2 --N(R.sup.3) (R.sup.4), .dbd.CH--CH.sub.2 --NHR.sup.5 or .dbd.CH--CHO or Z.sup.1 is a hydrogen atom and Z.sup.2 is --CH.sub.2 COOH, --CH.sub.2 COOR.sup.6, --CH(CN)COOR.sup.2, --CH.sub.2 CN, --CH.sub.2 --CO--NH.sub.2, --CH.dbd.CH--N(R.sup.3) (R.sup.4) or --CH.sub.2 --CH.dbd.N--R.sup.5, R.sup.1, R.sup.2 and R.sup.6 each being a lower alkyl group, R.sup.3 and R.sup.4 each independently being a lower-alkyl, cycloalkyl, aryl or aralkyl group or R.sup.3 and R.sup.4 combinedly representing an alkylene group containing 2-5 carbon atoms, and R.sup.5 being a lower-alkyl, cycloalkyl, aryl or aralkyl group.Type: GrantFiled: February 17, 1983Date of Patent: January 14, 1986Assignee: Kuraray Co., Ltd.Inventors: Tetsuo Takigawa, Koichi Ibata, Masafumi Okada, Masao Mizuno, Takashi Nishida
-
Patent number: 4558120Abstract: Dense star polymers having terminal group densities greater than conventional star polymers exhibit greater and more uniform reactivity than their corresponding conventional star polymers. For example, a third generation, amine-terminated polyamidoamine dense star polymer prepared from ammonia, methyl acrylate and ethylenediamine has 1.24.times.10.sup.-4 amine moieties per unit volume (cubic Angstrom units) in contrast to the 1.58.times.10.sup.-6 amine moieties per unit volume contained by a conventional star polymer. Such dense star polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, and agents for modifying viscosity in aqueous formulations such as paints.Type: GrantFiled: December 27, 1983Date of Patent: December 10, 1985Assignee: The Dow Chemical CompanyInventors: Donald A. Tomalia, James R. Dewald
-
Patent number: 4558071Abstract: Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K.sub.cat type.Type: GrantFiled: February 25, 1983Date of Patent: December 10, 1985Assignee: Merck & Co., Inc.Inventor: Raymond A. Firestone
-
Patent number: 4551550Abstract: 1. A compound of the formula:H.sub.2 C.dbd.C.dbd.CHCH.sub.2 NHCH.sub.2 --Z--CH.sub.2 NHRwherein:Z is --CH.sub.2 CH.sub.2 -- or trans-CH.dbd.CH--,R is H, CH.sub.3 --, CH.sub.3 CH.sub.2, CH.sub.3 (CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 NH.sub.2, --(CH.sub.2).sub.3 NHCOCH.sub.3, --CH.sub.2 CH.dbd.CH.sub.2, or --CH.sub.2 CH.dbd.C.dbd.CH.sub.2,or a pharmaceutically acceptable acid addition salt thereof are inhibitors of polyamine oxidase.Type: GrantFiled: December 17, 1984Date of Patent: November 5, 1985Assignee: Merrell Dow Pharmaceuticals Inc.Inventor: Philippe Bey
-
Patent number: 4503217Abstract: An aminomethylation reaction is disclosed wherein polymeric polyamines are produced. Polymeric polyolefins such as polybutadiene, ammonia, primary or secondary amines, and synthesis gas are reacted in the presence of a catalyst system comprising a ruthenium-containing catalyst, such as triruthenium dodecacarbonyl, and dimethyl formamide as a solvent.The use of a two-phase solvent mixture consisting of N,N-dimethylformamide plus a hydrocarbon is particularly advantageous in that:(1) The aminomethylation selectivity is improved and few side reactions results;(2) The two-phase liquid product mixture obtained, allows easy separation of product polyamine from ruthenium-containing catalyst.Type: GrantFiled: November 10, 1983Date of Patent: March 5, 1985Assignee: Texaco Inc.Inventors: David C. Alexander, John F. Knifton, Susan D. Unvert
-
Patent number: 4472318Abstract: Novel 10-amino-deca-3,7-diene-nitriles of the formula ##STR1## are described, in which R.sub.1 is C.sub.1-12 -alkyl, R.sub.2 is H or C.sub.1-12 -alkyl, R.sub.3 is C.sub.1-12 -alkyl, cycloalkyl having 4-12 ring C atoms, C.sub.7-8 -aralkyl, substituted or unsubstituted aryl or, if R.sub.4 =H, --Ch.dbd.CH--alkyl or --C(alkyl).dbd.CH--alkyl each having 1-4 C atoms in the alkyl groups, and R.sub.4 =H, C.sub.1-12 -alkyl, cycloalkyl having 4-12 ring C atoms, C.sub.7-8 -aralkyl or substituted or unsubstituted aryl, or R.sub.1 and R.sub.2 and/or R.sub.3 and R.sub.4 together are C.sub.3-11 -alkylene. The compounds (I) can be reduced in a manner known per se to give the corresponding 1,11-diamino-undeca-3,7-dienes. The latter are valuable intermediates and are suitable especially for the preparation of transparent crosslinkable polyamides.Type: GrantFiled: January 26, 1983Date of Patent: September 18, 1984Assignee: Ciba-Geigy CorporationInventors: Dieter Reinehr, Josef Pfeifer
-
Patent number: 4446151Abstract: Novel fluorinated diamine derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general Formula I: ##STR1## wherein: R.sub.c represents hydrogen or carboxy;R.sub.1 represents hydrogen or C.sub.1 -C.sub.6 alkyl;Z represents methylene or oxygen;m and n each represent 0 or 1 but m+n=1; andp represents 1 or 2.Type: GrantFiled: August 11, 1982Date of Patent: May 1, 1984Assignee: Merrell Toraude et CompagnieInventors: Fritz Gerhart, Viviane Van Dorsselaer
-
Patent number: 4439619Abstract: Fluorinated alkenylene diamine compounds are inhibitors of ornithine decarboxylase enzyme in vivo and have the following formula: ##STR1## wherein: R.sub.a represents hydrogen or R.sub.2, where R.sub.2 is as defined below;R.sub.b represents hydrogen or, when R.sub.a is hydrogen, R.sub.2, where R.sub.2 is as defined below;R.sub.c represents hydrogen or --COR.sub.3, where R.sub.3 is as defined below;R.sub.1 represents hydrogen or C.sub.1 --C.sub.6 alkyl;each R.sub.2, independently, represents C.sub.2 -C.sub.5 alkylcarbonyl, phenylcarbonyl, phenyl-(C.sub.1 -C.sub.4 alkyl) carbonyl, or an aminocarboxylic acid residue derived by removal of an hydroxy group from a carboxy moiety of an L-aminocarboxylic acid;R.sub.3 represents hydroxy, or, when R.sub.a and R.sub.b are both hydrogen, C.sub.1 -C.sub.8 alkoxy, --NR.sub.4 R.sub.5, where R.sub.4 and R.sub.5 are as defined below, or an aminocarboxylic acid residue derived by removal of an hydrogen atom from the amino moiety of an L-aminocarboxylic acid;R.sub.4 and R.sub.Type: GrantFiled: August 21, 1981Date of Patent: March 27, 1984Assignee: Merrell Toraude et CompagnieInventors: Philippe Bey, Fritz Gerhart, Michel Jung
-
Patent number: 4426321Abstract: This invention discloses a number of novel odorant alkadienyl ketones, alcohols and oximes having from 9 to 15 carbon atoms, processes for making same and odorant compositions containing same.Type: GrantFiled: July 24, 1981Date of Patent: January 17, 1984Assignee: Givaudan CorporationInventor: Paul A. Ochsner
-
Patent number: 4423073Abstract: Novel fluorinated alkenylene diamine derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general Formula I: ##STR1## wherein: R.sub.c represents hydrogen or --COR.sub.5, where R.sub.5 is as defined below;R.sub.1 represents hydrogen or C.sub.1 -C.sub.6 alkyl;one of R.sub.2 and R.sub.3 represents hydrogen and the other represents C.sub.1 -C.sub.6 alkyl.R.sub.5 represents hydroxy or C.sub.1 -C.sub.8 alkoxy; andp represents 1 or 2.Type: GrantFiled: August 11, 1982Date of Patent: December 27, 1983Assignee: Merrell Toraude et CompagnieInventors: Fritz Gerhart, Viviane Van Dorsselaer
-
Patent number: 4421768Abstract: Novel fluorinated diamino-heptene and-heptyne derivatives are inhibitors of ornithine decarboxylase enzyme involved in polyamine formation and have the following general Formula I: ##STR1## wherein: Y represents CH.sub.2 .dbd.CH-- or CH.tbd.C--; andp represents 1 or 2.Type: GrantFiled: August 11, 1982Date of Patent: December 20, 1983Assignee: Merrell Toraude et CompagnieInventors: Patrick Casara, Charles Danzin
-
Patent number: 4419266Abstract: An aqueous composition for inhibiting the corrosion of metals is described. The composition comprises a non-oxidizing acid, and, as a corrosion inhibitor, an effective amount of a 3-dialkylamino-3-(1-ethylpentyl)prop-1-yne.Type: GrantFiled: February 25, 1982Date of Patent: December 6, 1983Assignee: GAF CorporationInventors: Eugene V. Hort, Lowell R. Anderson, Dru W. Alwani
-
Patent number: 4388475Abstract: Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K.sub.cat type.Type: GrantFiled: May 7, 1980Date of Patent: June 14, 1983Assignee: Merck & Co., Inc.Inventor: Raymond A. Firestone
-
Patent number: 4381223Abstract: This invention provides for the separation of an amine composition undergoing processing at high temperatures and pressures which amine composition contains volatile components and less volatile components where the volatile components are desirable for further processing and/or utilization and the less volatile components are less desirable for further processing and/or utilization. The separation serves to divide the amine composition into two streams, one which is enriched in the volatile components and the other which is enriched in the less volatile components.Type: GrantFiled: September 30, 1981Date of Patent: April 26, 1983Assignee: Union Carbide CorporationInventors: Charles A. Gibson, Moinuddin Ahmed, Michael Habenschuss
-
Patent number: 4375477Abstract: Beta-monofluoromethyl beta-alanine, beta-difluoromethyl beta-alanine and pharmaceutically acceptable esters and amides derived from the acid group, amides derived from the amine group, and salts thereof are novel compounds which inhibit .gamma.-aminobutyric acid transaminase (GABA-T).Type: GrantFiled: July 21, 1980Date of Patent: March 1, 1983Assignee: Merrell Toraude et CompagnieInventors: Philippe Bey, Michael Jung, Fritz Gerhart
-
Patent number: 4357476Abstract: New nonadienylamines, nonatrienylamines and nonylamines are described, as well as a new process for their manufacture by reacting a 1,3-diolefine with a Schiff's base in the presence of certain nickel catalysts. The new compounds are suitable for combating micro-organisms, for example in the protection of materials.Type: GrantFiled: November 22, 1978Date of Patent: November 2, 1982Assignee: Ciba Geigy Corporation, N.Y.Inventors: Dieter Reinchr, Bernard Hugelin, Eduard Troxler
-
Patent number: 4353828Abstract: Fluorinated alkenylamines of the Formula V ##STR1## wherein n represents 0, 1, 2 or 3; R.sub.1 represents hydrogen or C.sub.1 -C.sub.10 alkyl and Y represents (a), when n represents O, CH.sub.2 F, (b), when n represents 1, CH.sub.2 F or CHF.sub.2, or (c) when n represents 2 or 3, CH.sub.2 F, CHF.sub.2 or CF.sub.3 are novel process intermediates. They are obtained by hydrolysis and subsequent reduction of the corresponding alkenyl fluorinated methyl ketimine magnesium halides, which are novel compounds resulting from reaction of the corresponding alkenyl magnesium halides with the corresponding fluorinated acetonitriles. The fluorinated alkenylamines of Formula V are oxidized while the amino group is protected to provide, after removal of the amine protecting group, the corresponding fluorinated methyl aminoalkanoic acids which are useful pharmacological or anti-bacterial agents.Type: GrantFiled: July 21, 1980Date of Patent: October 12, 1982Assignee: Merrell Toraude et CompagnieInventors: Philippe Bey, Fritz Gerhart, Viviane Van Dorsselaer
-
Patent number: 4352760Abstract: The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A.sub.2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.Type: GrantFiled: December 29, 1980Date of Patent: October 5, 1982Assignee: The Upjohn CompanyInventor: Kirk M. Maxey
-
Patent number: 4340760Abstract: Monophenylamine derivatives are prepared.Type: GrantFiled: April 22, 1981Date of Patent: July 20, 1982Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yoshiyuki Tahara, Hiroyasu Koyama, Yasuhiro Komatsu, Reiko Kubota, Toshihiro Takahashi
-
Patent number: 4324916Abstract: Decaprenylamine derivatives and their acid addition salts are described which are useful for the control of virus infections of vertebrate animals.Type: GrantFiled: November 19, 1980Date of Patent: April 13, 1982Assignee: Nisshin Flour Milling Co. Ltd.Inventors: Yoshiyuki Tahara, Hiroyasu Koyama, Yasuhiro Komatsu, Reiko Kubota, Toshihiro Takahashi
-
Patent number: 4322555Abstract: This invention relates to new nonaprenylamine derivatives and the acid addition salts thereof, which are useful for controlling virus infection of vertebrate animals.Type: GrantFiled: April 22, 1981Date of Patent: March 30, 1982Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yoshiyuki Tahara, Hiroyasu Koyama, Yasuhiro Komatsu, Reiko Kubota, Toshihiro Takahashi
-
Patent number: 4322537Abstract: Tertiary amines in which at least one group bonded directly to the nitrogen atom is alkyl of 2 to 20 carbon atoms or in which two or more groups bonded directly to the nitrogen atom together are alkylene of 4 to 7 carbon atoms, are oxidized by trihaloacetyl anhydride or trihaloacetyl halide to mono- and di-trihaloacetylated alpha, beta-enamines.Type: GrantFiled: June 2, 1980Date of Patent: March 30, 1982Assignee: President and Fellows of Harvard CollegeInventor: Stuart L. Schreiber
-
Patent number: 4284827Abstract: Substituted ethanes (I) are reacted with an alkyl metal reagent to form isomeric metalated olefins (IIIA and IIIB) having a trans (IIIB) to cis (IIIA) ratio of greater than 70:30.Type: GrantFiled: December 17, 1979Date of Patent: August 18, 1981Assignee: The Upjohn CompanyInventor: Jerry A. Walker
-
Patent number: 4275237Abstract: Heavy reaction product after separation as by distillation of light reaction product or diadduct from a reaction mixture obtained by reaction of olefinically unsaturated nitriles with monoolefinic hydrocarbons containing an allylic hydrogen atom is hydrogenated to produce a polyamine mixture useful as an epoxy resin hardener yielding cured resins exhibiting low water absorption.Type: GrantFiled: August 6, 1979Date of Patent: June 23, 1981Assignee: Philips Petroleum CompanyInventors: Charles A. Drake, Ralph P. Williams
-
Patent number: 4269626Abstract: An aqueous agent for treating wood and wooden materials, optionally containing customary additives, such as water-soluble wood protecting agents effective as insecticides and/or fungicides, comprises an organic binder drying by oxidation, said organic binder consisting essentially of the reaction product of an acid and a 1,3-butadiene substrate polymer modified to carry amino groups, wherein(1) the amino group carrying 1,3-butadiene polymer has a double bond content corresponding to an iodine number of at least 200 g iodine/100 g, of which a double bond content of at least 100, measured as iodine number, is derived from cis-1,4-structural elements of the 1,3-butadiene substrate polymer per se;(2) the amino group content of the amino group carrying 1,3-butadiene polymer is at least 50 mg-atoms of nitrogen/100 g of polymer; and(3) the 1,3-butadiene substrate polymer per se has at least 70 molar percent butadiene units and a molecular weight (Mn) of 500-6,000.Type: GrantFiled: September 7, 1979Date of Patent: May 26, 1981Assignee: Chemische Werke Heuls, A.G.Inventors: Klaus Gorke, Wilfried Bartz
-
Patent number: 4267374Abstract: Novel compounds of the formula ##STR1## wherein A is methylene, ethylene or ethylidene; R.sub.1 is --C.tbd.CH or --CH.dbd.CH.sub.2 ; R.sub.2 is hydrogen or COR wherein R is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.4 R.sub.5 wherein each of R.sub.4 and R.sub.5 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms or ##STR2## wherein R.sub.6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R.sub.a is hydrogen, ##STR3## alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR4## wherein R.sub.7 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; and R.sub.b has the same meaning as defined for R.sub.a except R.sub.b is not ##STR5## and R.sub.a and R.sub.Type: GrantFiled: June 25, 1979Date of Patent: May 12, 1981Assignee: Merrell Toraude et CompagnieInventors: Brian W. Metcalf, Michel Jung, Charles Danzin
-
Patent number: 4267366Abstract: Disclosed are novel cyclic terpenoid amines which can be prepared by cyclizing the corresponding acyclic terpenoid amine.Type: GrantFiled: June 18, 1979Date of Patent: May 12, 1981Assignee: SCM CorporationInventors: Bernard J. Kane, Richard A. Von Genk
-
Patent number: 4265910Abstract: This invention relates to new isoprenylamines and the acid addition salts thereof. Further, the invention is concerned with antiviral agents for vertebrate animal, said agents containing as their active ingredients isoprenylamine or physiologically acceptable acid addition salt thereof.Type: GrantFiled: May 1, 1980Date of Patent: May 5, 1981Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yoshiyuki Tahara, Hiroyasu Koyama, Yasuhiro Komatsu, Reiko Kubota, Toshihiro Takahashi
-
Patent number: 4264614Abstract: The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, =CHNO.sub.2 or =NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.Type: GrantFiled: November 16, 1979Date of Patent: April 28, 1981Assignee: Glaxo Group LimitedInventors: John W. Clitherow, Barry J. Price, John Bradshaw
-
Patent number: 4244890Abstract: Disclosed are novel cyclic terpenoid amines which can be prepared by cyclizing the corresponding acyclic terpenoid amine.CROSS REFERENCE TO RELATED APPLICATIONSThis application is related to applicant's commonly owned copending application Ser. No. 916,966 filed 19 June 1978, now U.S. Pat. No. 4,179,468 dated 18 Dec. 1979 and entitled Cyclic Terpenoid Onium Salts, Their Preparation and Uses.Type: GrantFiled: December 14, 1977Date of Patent: January 13, 1981Assignee: SCM CorporationInventors: Bernard J. Kane, Richard A. Von Genk