Alicyclic Ring Containing Patents (Class 564/57)
-
Patent number: 10301277Abstract: A cyclohexane derivative as shown by formula IB or a stereoisomer or a salt thereof, has a high affinity for D3 receptors and 5-hydroxytryptamine, has a lower affinity for D2 receptors, shows a high selectivity for D3/D2 receptors, and can be used as a therapeutic drug against neuropsychiatric diseases. wherein; X is N or CH; R is R is optionally substituted with one or more substituents selected from the group consisting of F, Cl, Br, I and C1-C6 alkyl; and the C1-C6 alkyl is optionally substituted with one or more substituents selected from the group consisting of F, Cl, Br, and I.Type: GrantFiled: September 14, 2016Date of Patent: May 28, 2019Assignees: ZHEJIANG JINGXIN PHARMACEUTICAL CO., LTD., SHANGHAI JINGXIN BIOMEDICAL CO., LTD., SHANGYU JINGXIN PHARMACEUTICAL CO., LTD.Inventors: Yue Huang, Fei Zheng
-
Publication number: 20150133676Abstract: The present disclosure relates to a method for preparing a disubstituted urea and carbamate compounds simultaneously through a one-pot reaction of an amine, carbon dioxide and an alkylene oxide compound in the presence of an ionic liquid-based complex catalyst system containing indium. In accordance with the present disclosure, a disubstituted urea and carbamate compounds can be prepared simultaneously at high yield. In addition, the ionic liquid-based catalyst containing indium according to the present disclosure is economical because it can be reused several times.Type: ApplicationFiled: December 20, 2013Publication date: May 14, 2015Applicant: Korea Institute of Industrial TechnologyInventors: Yong Jin Kim, Vivek Mishra, Guang Meang Son, Jin Ku Cho, Baek Jin Kim
-
Patent number: 8940935Abstract: The disclosure provides curable inks including a bis-urea gelator having the structure of Formula I. wherein R and R? each, independently of the other, is a saturated aliphatic hydrocarbon group selected from the group consisting of (1) linear aliphatic groups, (2) branched aliphatic groups, (3) cyclic aliphatic groups, (4) aliphatic groups containing both cyclic and acyclic portions, any carbon atom of the saturated aliphatic hydrocarbon group may be optionally substituted with an alkyl group (cyclic or acyclic), wherein (1) and (2) groups have a carbon number of from about 1 to about 22 carbons, and wherein (3) and (4) groups have a carbon number of from about 4 to about 10 carbons; and X is selected from the group consisting of: (i) an alkylene group, (ii) an arylene group, (iii) an arylalkylene group, and (iv) an alkylarylene group.Type: GrantFiled: January 28, 2013Date of Patent: January 27, 2015Assignee: Xerox CorporationInventors: Naveen Chopra, Michelle N. Chretien, Barkev Keoshkerian, Jenny Eliyahu, Daryl W. Vanbesien, Adela Goredema
-
Patent number: 8884059Abstract: The present invention is directed towards an electrocoating composition comprising a cyclic guanidine.Type: GrantFiled: September 17, 2010Date of Patent: November 11, 2014Assignee: PPG Industries Ohio, Inc.Inventors: Steven R. Zawacky, Thomas C. Moriarity, Donald W. Boyd, Geoffrey R. Webster, Joseph Lucas, Alan J. Kaylo, Chester J. Szymanski, Venkatachalam Eswarakrishnan
-
Patent number: 8877968Abstract: Melanocortin receptor modulators, processes for preparing them and use thereof in human medicine and cosmetics are described. Melanocortin receptor modulators corresponding to formula (I): compositions containing them, processes for their preparation and their use in pharmaceutical or cosmetic compositions are also described.Type: GrantFiled: November 4, 2009Date of Patent: November 4, 2014Assignee: Galderma Research & DevelopmentInventors: Claire Bouix-Peter, Itaru Suzuki, Isabelle Pelisson, Pascal Collette, Samuel Tabet, Guillaume Lafitte
-
Publication number: 20140213820Abstract: The disclosure provides curable inks including a bis-urea gelator having the structure of Formula I. wherein R and R? each, independently of the other, is a saturated aliphatic hydrocarbon group selected from the group consisting of (1) linear aliphatic groups, (2) branched aliphatic groups, (3) cyclic aliphatic groups, (4) aliphatic groups containing both cyclic and acyclic portions, any carbon atom of the saturated aliphatic hydrocarbon group may be optionally substituted with an alkyl group (cyclic or acyclic), wherein (1) and (2) groups have a carbon number of from about 1 to about 22 carbons, and wherein (3) and (4) groups have a carbon number of from about 4 to about 10 carbons; and X is selected from the group consisting of: (i) an alkylene group, (ii) an arylene group, (iii) an arylalkylene group, and (iv) an alkylarylene group.Type: ApplicationFiled: January 28, 2013Publication date: July 31, 2014Applicant: XEROX CORPORATIONInventors: Naveen Chopra, Michelle N. Chretien, Barkev Keoshkerian, Jenny Eliyahu, Daryl W. Vanbesien, Adela Goredema
-
Publication number: 20130251929Abstract: The present invention relates to a polymer composition comprising at least one polyamide and at least one urea compound of the formula I where x is 1, 2 or 3; R1 and R2 are selected from hydrogen, linear C1-C7-alkyl, branched C3-C10-alkyl, unsubstituted or substituted C3-C12-cycloalkyl, unsubstituted or substituted C3-C12-cycloalkyl-C1-C4-alkyl, unsubstituted or substituted aryl and unsubstituted or substituted aryl-C1-C4-alkyl; and Z is selected from C3-C10-alkanediyl, unsubstituted or substituted arylene, unsubstituted or substituted aryl unsubstituted or substituted ene-C1-C4-alkylene-arylene, unsubstituted or substituted heteroarylene, unsubstituted or substituted heteroarylene-C1-C4-alkylene-heteroarylene, unsubstituted or substituted C5-C8-cycloalkylene, C5-C8-cycloalkylene-C1-C4-alkylene-C5-C8-cycloalkylene, unsubstituted or substituted heterocycloalkylene and heterocycloalkylene-C1-C4-alkylene-heterocycloalkylene.Type: ApplicationFiled: March 20, 2013Publication date: September 26, 2013Applicant: BASF SEInventors: Claus Gabriel, Hans-Werner Schmidt, Florian Richter
-
Patent number: 8466200Abstract: The present invention relates to 2-adamantylurea derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11?-HSD1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.Type: GrantFiled: February 7, 2012Date of Patent: June 18, 2013Assignee: Merck Patent GmbHInventors: Denis Carniato, Christine Charon, Johannes Gleitz, Didier Roche, Bjoern Hock
-
Publication number: 20130065963Abstract: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.Type: ApplicationFiled: July 17, 2012Publication date: March 14, 2013Applicant: Georgetown UniversityInventors: Alan P. Kozikowski, Anatoly Dritschilo, Mira Jung, Pavel A. Petukhov, Bin Chen
-
Publication number: 20130023510Abstract: The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.Type: ApplicationFiled: May 25, 2012Publication date: January 24, 2013Applicant: Cytometix, Inc.Inventors: Lane Brostrom, John R. Falck
-
Publication number: 20120178942Abstract: Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.Type: ApplicationFiled: July 27, 2010Publication date: July 12, 2012Inventors: John Traverse, William M. Leong, Steven P. Miller, Jennifer Albaneze-Walker, Thomas J. Hunter, Lijun Wang, Hongbiao Liao, Ashok Arasappan, Scott T. Trzaska, Randi M. Smith, Azzeddine Lekhal, Stephane L. Bogen, Jianshe Kong, Frank Bennett, F. George Njoroge, Marc Poirier, Shen-Chun Kuo, Yonggang Chen, Kenneth S. Matthews, Patrice Demonchaux, Amadeo Ferreira
-
Patent number: 8058475Abstract: Novel cyclohexylmethyl compounds corresponding to formula I wherein R1, R2, R3, R4 and R5, have the meanings given in the description. Pharmaceutical formulations containing these compounds, as well as a processes for preparing these compounds and related methods of treatment are also provided.Type: GrantFiled: June 20, 2008Date of Patent: November 15, 2011Assignee: Gruenenthal GmbHInventors: Stefan Oberboersch, Beatrix Merla, Bernd Sundermann, Werner Englberger, Hagen-Heinrich Hennies, Achim Kless, Petra Bloms-Funke, Babette-Yvonne Koegel, Heinze Graubaum
-
Patent number: 7893184Abstract: Dendritic or hyperbranched polyurethanes are prepared by 1) reacting diols or polyols having at least one tertiary nitrogen atom and at least two hydroxyl groups of differing reactivity toward isocyanate groups with diisocyanates or polyisocyanates to form an addition product, with the diols or polyols and diisocyanates or polyisocyanates being selected so that the addition product has, on average, one isocyanate group and more than one hydroxyl group or one hydroxyl group and more than one isocyanate group, 2) converting the addition product from step 1) into a polyaddition product by intermolecular reaction of the hydroxyl groups with the isocyanate groups, and with a reaction with a compound containing at least two hydroxyl groups, mercapto groups, amino groups or isocyanate groups also being able to be carried out first, 3) if desired reacting the polyaddition product from step 2) with a compound containing at least two hydroxyl groups, mercapto groups, amino groups or isocyanate groups.Type: GrantFiled: May 14, 2004Date of Patent: February 22, 2011Assignee: BASF AktiengesellschaftInventors: Bernd Bruchmann, Jean-Francois Stumbe
-
Publication number: 20110028559Abstract: Treating pain in mammals with a compound having the formula (I) is disclosed herein.Type: ApplicationFiled: June 20, 2008Publication date: February 3, 2011Inventors: Wenkui k. Fang, Ken Chow, Daniel W. Gil, Evelyn G. Corpuz, Michael E. Garst
-
Publication number: 20110021448Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.Type: ApplicationFiled: December 4, 2009Publication date: January 27, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: BRUCE D. HAMMOCK, IN-HAE KIM, CHRISTOPHE MORISSEAU, TAKAHO WATANABE, JOHN W. NEWMAN
-
Patent number: 7795468Abstract: This invention is directed to functionalized higher diamondoids having at least one functional group. Preferably these derivatives have the following Formula I: wherein D is a higher diamondoid nucleus and wherein R1, R2, R3, R4, R5 and R6 are independently selected from a group consisting of hydrogen and functional groups, provided that there is at least one functional group on the derivative. The functionalized higher diamondoid compounds may also be of the formula D—L—(D)n wherein D is a higher diamondoid nucleus and L is a linking group and n is 1 or more. The functionalized higher diamondoid compounds additionally may be of the formula R38—D—D—R39 wherein D is a higher diamondoid nucleus and R38 and R39 are substituents.Type: GrantFiled: December 6, 2002Date of Patent: September 14, 2010Assignee: Chevron U.S.A. Inc.Inventors: Shenggao Liu, Robert M. Carlson, Jeremy E. Dahl, Waqar R. Qureshi
-
Patent number: 7718385Abstract: A rapid screening method for identifying acylfulvenes and acylfulvene analogs with improved chemotherapeutic properties has been developed. The mechanism of toxicity of irofulven, a potentially clinically useful member of the acylfulvene class, has been elucidated and provides guidance for design and testing of a new class of alkylating agents with structures related to irofulven. The role of alkenal/one oxidoreductase (AOR) is shown to be important in cancer cell susceptibility to this class of alkylating agent.Type: GrantFiled: October 18, 2004Date of Patent: May 18, 2010Assignee: The Johns Hopkins UniversityInventor: Ryan A. Dick
-
Patent number: 7655695Abstract: Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neoplastic agents, i.e., to inhibit tumor cell growth in vitro or in vivo, in mammalian hosts, such as humans or animals, e.g., domestic animals, and are effective against solid tumors, hematologic malignancies and multi-drug resistant cancers/tumors. The present compounds can be used alone or they can be used in combination with one or more anti-cancer or anti-tumor agents.Type: GrantFiled: August 3, 2006Date of Patent: February 2, 2010Assignee: The Regents of The University of CaliforniaInventors: Trevor C. McMorris, Michael J. Kelner
-
Patent number: 7601870Abstract: The present invention relates to aniline derivatives of the general formula I or salts thereof, described therein, and their use.Type: GrantFiled: December 20, 2005Date of Patent: October 13, 2009Assignee: H. Lundbeck A/SInventors: Christian Wenzel Tornøe, Mario Rottländer, Daniel Rodriguez Greve, Nikolay Khanzhin, Andreas Ritzén, William Patrick Watson
-
Patent number: 7598417Abstract: The present patent application is directed to novel fluoroethyl urea compounds and compositions and their therapeutic use in the treatment of pain and other conditions.Type: GrantFiled: March 28, 2008Date of Patent: October 6, 2009Assignee: Allergan, Inc.Inventors: Ken Chow, Wenkui K. Fang, Evelyn G. Corpuz, Daniel W. Gil, Michael E. Garst
-
Patent number: 7531577Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein Ar, X, m, R1, R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I for treatment of 5-HT6-mediated diseases.Type: GrantFiled: June 20, 2007Date of Patent: May 12, 2009Assignee: Roche Palo Alto LLCInventors: Ralph New Harris, III, James M. Kress, David Bruce Repke, Russell Stephen Stabler
-
Publication number: 20090082595Abstract: The invention is directed to a process for the production of certain phosphorous, namely urea, thio-urea and sulphonamide phosphorous compounds. The present invention provides a process for the production of phosphorous compounds which process allows an easy and effective separation of the reaction products from impurities by applying a solid alkaline ion-exchange resin.Type: ApplicationFiled: January 26, 2007Publication date: March 26, 2009Applicants: ENGELHARD DE MEERN B.V., UNIVERSITEIT VAN AMSTERDAMInventors: Albertus Jacobus Sandee, Alida Maria Van Der Burg, Joost Nicolaas Hendrik Reek
-
Publication number: 20090082456Abstract: Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetic-related diseases.Type: ApplicationFiled: September 9, 2008Publication date: March 26, 2009Inventor: Richard D. Gless, JR.
-
Patent number: 7504538Abstract: The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of pain and disorders related thereto as well as a method for treatment of pain and disorders related thereto, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.Type: GrantFiled: October 14, 2004Date of Patent: March 17, 2009Assignee: Cara Therapeutics, Inc.Inventors: Chia-Ping Chang, Jacek Stalewski, Piere J-M. Riviere, Kazimierz A. Wisniewski, Claudio D. Schteingart
-
Publication number: 20080306147Abstract: Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neoplastic agents, i.e., to inhibit tumor cell growth in vitro or in vivo, in mammalian hosts, such as humans or animals, e.g., domestic animals, and are effective against solid tumors, hematologic malignancies and multi-drug resistant cancers/tumors. The present compounds can be used alone or they can be used in combination with one or more anti-cancer or anti-tumor agents.Type: ApplicationFiled: August 3, 2006Publication date: December 11, 2008Applicant: The Regents of The University of California Office of Technology TransferInventors: Trevor C. McMorris, Michael J. Kelner
-
Patent number: 7339020Abstract: High-functionality polyisocyanates are prepared by a process which comprises (i) preparation of an addition product (A) which contains one group which is reactive toward isocyanate and at least two isocyanate groups by reacting (a) a diisocyanate or polyisocyanate I with (b1) compounds having at least three groups which are reactive toward isocyanate or (b2) compounds containing two groups which are reactive toward isocyanate or mixtures of (b1) and (b2), where at least one of the components (a) or (b) has functional groups having differing reactivities toward the functional groups of the other component and the reaction ratio is selected so that the addition product (A) contains an average of one group which is reactive toward isocyanate, (ii) if desired, intermolecular addition reaction of the addition product (A) to form a polyaddition product (P) containing an average of one group which is reactive toward isocyanate and an average of more than two isocyanate groups, and (iii) reaction of the additionType: GrantFiled: March 19, 2001Date of Patent: March 4, 2008Assignee: BASF AktiengesellschaftInventors: Bernd Bruchmann, Hans Renz, Rainer Königer, Ulrike Ehe, Ulrich Treuling, Rudolf Müller-Mall
-
Patent number: 7232929Abstract: The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain.Type: GrantFiled: February 15, 2004Date of Patent: June 19, 2007Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Meir Bialer, Boris Yagen, Eyal Sobol, Dan Kaufmann
-
Patent number: 7087676Abstract: Blocked polyisocyanates and one-component stoving systems containing these blocked polyisocyanates, and the preparation thereof and their use for the preparation of lacquers, paints, adhesives and elastomers, wherein blocked polyisocyanates are prepared by reacting polyisocyanates with secondary amines corresponding to the formula wherein R1—R4 can be identical or different and denote hydrogen, C1–C6-alkyl or cycloalkyl, R5 denotes C1–C10-alkyl, C3–C10-cycloalkyl, y denotes a number from 2 to 8, and B represents wherein R6–R8 can be identical or different and independently of one another denote C1–6-alkyl and/or C3–C6-cycloalkyl, R9 denotes hydrogen or C1–6-alkyl or C3–C6-cycloalkyl.Type: GrantFiled: June 23, 2004Date of Patent: August 8, 2006Assignee: Bayer Materialscience AGInventors: Jan Mazanek, Reinhard Halpaap, Markus Mechtel, Thomas Klimmasch, Christoph Thiebes
-
Patent number: 7053244Abstract: The invention relates to a process for the preparation of tetrasubstituted ureas by reaction of the corresponding amines with phosgene in the presence of an aqueous inorganic base at a temperature in the range from 0 to 150° C., which comprises: feeding the corresponding amine, the phosgene and the aqueous inorganic base on average continuously to the reaction apparatus, forming a two-phase system in the reaction apparatus through the choice of the tetrasubstituted ureas to be prepared, through the mixing ratios of the substances and substance mixtures to be fed in, through the temperature during the reaction and, where appropriate, through the feed of an organic solvent which is not completely miscible with water, and discharging the reaction mixture on average continuously from the reaction apparatus.Type: GrantFiled: July 3, 2003Date of Patent: May 30, 2006Assignee: BASF AktiengesellschaftInventors: Jochem Henkelmann, Theodor Weber, Thorsten Rohde, Ralph Busch
-
Patent number: 6756500Abstract: A process for preparing a cyclic compound comprising subjecting a starting material in the presence of a catalyst component to metathesis reaction in the presence of an ionic liquid, wherein the starting material is a &agr;,&ohgr;-diene bearing a &agr; substituent NRR1 in the &agr; position to a double bond, wherein R is hydrogen or an organic substituent, R1 is tert-butyl, P(R)2, P(R2)2, COR, SO2PhR, COOR or CONRR2, R2is alkyl or phenyl, or R and R1 together form and in which &agr;,&ohgr;-dienes optionally bear at least one further substituent R in any other position with the exception of the &agr; position, wherein R is selected from the group consisting of hydrogen, fused or unfused aryl, alkyl, CN, COOR2 or halogen, and wherein the starting material optionally contains a member selected from the group containing at least one further substituent that is inert in the metathesis reaction and a heteroatom selected from the group consisting of branched alkyl radicals, unbranched alkyl radicalType: GrantFiled: February 25, 2000Date of Patent: June 29, 2004Assignee: Bayer AktiengesellschaftInventors: Christoph Gürtler, Manfred Jautelat
-
Patent number: 6723875Abstract: The present invention relates to the preparation of alkyl-ureas, starting from O,S-dimethyl dithiocarbonate, which provides the following steps: A) causing the O,S-dimethyl dithiocarbonate to react with a primary amine of general formula R1NH2 in order to obtain an O-methyl thiocarbamate; B) isomerising the O-methyl thiocarbamate in order to obtain an S-methyl thiocarbamate; C) causing the S-methyl thiocarbamate with a compound of general formula R′R″NH, wherein R′ and R″ may be equal or different one in respect of the other and of R1 and may be H, R2 or R3, in order to obtain one of the alkyl-ureas of formula (4), (5) or (6).Type: GrantFiled: February 6, 2003Date of Patent: April 20, 2004Assignee: Oxon Italia S.p.A.Inventors: Edoardo Pallucca, Jacopo Degani, Anna Maria Serri, Rita Fochi, Sonia Gazzetto, Claudia Fenoglio, Claudio Ornati, Mara Migliaccio, Silvano Cadamuro, Gianni Carvoli
-
Patent number: 6683200Abstract: N-Substituted-N′-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF-&agr; production inhibitory activity.Type: GrantFiled: October 4, 2001Date of Patent: January 27, 2004Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Shiro Mita, Masato Horiuchi, Masakazu Ban, Hiroshi Suhara
-
Publication number: 20040014758Abstract: The present application describes modulators of CCR3 of formula (I): 1Type: ApplicationFiled: July 3, 2003Publication date: January 22, 2004Inventors: Dean A. Wacker, John V. Duncia, Joseph B. Santella, Daniel S. Gardner
-
Publication number: 20030216434Abstract: The present application describes modulators of MCP-1 of formula (I): 1Type: ApplicationFiled: March 7, 2003Publication date: November 20, 2003Inventor: Robert J. Cherney
-
Publication number: 20030199710Abstract: This invention is directed to functionalized higher diamondoids having at least one functional group.Type: ApplicationFiled: December 6, 2002Publication date: October 23, 2003Inventors: Shenggao Liu, Robert M. Carlson, Jeremy E. Dahl, Waqar R. Qureshi
-
Patent number: 6635783Abstract: Bicyclic amino alcohols, whose amino group and hydroxy group are bonded in positions 1,3 adjacent to the bridge, for example are valuable ligands for metal complexes of the d-8 metals of the periodic table of elements. The metal complexes in question are catalysts or catalyst precursors for the asymmetric hydrogenation or asymmetric transfer hydrogenation with hydrogen donors of prochiral organic compounds with carbon double bonds or carbon/hetero atom double bonds, for example ketones and imines.Type: GrantFiled: March 6, 2001Date of Patent: October 21, 2003Assignee: Solvias AGInventor: Peter Herold
-
Patent number: 6627774Abstract: Derivatives of N-deacetyl-thiocolchicine or of the isoster thereof of formula (I) wherein n is an integer from 0 to 8, Y is a CH2 group or, when n is 1, can also be a group of formula NH. Compounds of formula (I) have anti-proliferative activity.Type: GrantFiled: August 2, 2002Date of Patent: September 30, 2003Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Alessandro Pontiroli
-
Publication number: 20030181717Abstract: Novel chiral derivitaves of non-nucleoside inhibitors (NNI), particularly R-isomers of halopyridyl and thiazoyl thiourea compounds are provided as potent inhibitors of reverse transcriptase (RT), and particularly of retroviral RT, most particularly HIV RT. The stereospecific compounds and compositions of the invention inhibit replication of retrovirus, particularly human immunodeficiency virus-1 (HIV-1) and drug resistant strains.Type: ApplicationFiled: January 21, 2003Publication date: September 25, 2003Applicant: Parker Hughes Institute located at Roseville, MinnesotaInventors: Fatih M. Uckun, Taracad K. Venkatachalam
-
Patent number: 6620228Abstract: Resins and waxes made by reacting selected nucleophiles, including alcohols and/or amines, with an isocyanate are disclosed. The order of addition of the isocyanate and the different nucleophiles can tailor the distribution of di-urethane, mixed urethane/urea, and/or di-urea molecules in the final resin product. The isocyanate-derived resin and wax materials are useful as ingredients as phase change ink carrier compositions used to make phase change ink jet inks.Type: GrantFiled: May 13, 1998Date of Patent: September 16, 2003Assignee: Xerox CorporationInventors: Clifford R. King, Loc V. Bui, Jeffrey H. Banning, Donald R. Titterington
-
Patent number: 6583216Abstract: The present invention relates to blocked polyisocyanate cross-linking agents and their use in one-component stoving lacquers, in particular in solvent-containing or predominantly water-based plastics coatings having a soft-feel effect.Type: GrantFiled: June 3, 2002Date of Patent: June 24, 2003Assignee: Bayer AktiengesellschaftInventors: Eberhard König, Claus Kobusch, Uwe Klippert, Wolfram Küttner
-
Patent number: 6570038Abstract: Hexasubstituted guanidinium chlorides are prepared by a method which affords them in high yield as aqueous solutions, optionally also containing alkali metal chlorides. The solutions may be employed as sources of hexasubstituted guanidinium salts useful as phase transfer catalysts for the reaction of alkali metal salts of dihydroxyaromatic compounds with substituted imides to form polyetherimides or their intermediates.Type: GrantFiled: June 9, 2000Date of Patent: May 27, 2003Inventors: Joseph John Caringi, Peter David Phelps, Thomas Link Guggenheim, Daniel Joseph Brunelle
-
Patent number: 6531499Abstract: Peptoid compounds of Formula I and Formula II are disclosed The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.Type: GrantFiled: July 23, 2001Date of Patent: March 11, 2003Assignee: Wisconsin Alumni Research FoundationInventors: Donald T. Witiak, Paul J. Bertics, Yingsheng Zhang
-
Publication number: 20020198376Abstract: Objects of the present invention are to create compounds having urea structure as basic structure and having a sulfur atom and an amide bond in side chains and to find pharmacological effects thereof, particularly TNF-&agr; production inhibitory effects.Type: ApplicationFiled: May 15, 2002Publication date: December 26, 2002Applicant: SANTEN PHARMACEUTICAL CO., LTD.Inventors: Shiro Mita, Masato Horiuchi, Masakazu Ban, Hiroshi Suhara
-
Patent number: 6387949Abstract: Compounds of general formula I are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.Type: GrantFiled: June 1, 2000Date of Patent: May 14, 2002Assignee: AstraZeneca Canada Inc.Inventors: Daniel Delorme, Vlad Gregor, Niklas Plobeck, Edward Roberts, Eric Sun
-
Publication number: 20020045777Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.Type: ApplicationFiled: August 9, 2001Publication date: April 18, 2002Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
-
Patent number: 6353135Abstract: Aliphatic tetraketimine of the present invention are a novel class of compounds represented by the formula: wherein Et is ethyl, Me is methyl, and R is a residue of an aliphatic diisocyanate. The tetraketimine is made by condensing a novel ketimine with a diisocyanate. The ketimine has a free secondary amine after a polyamine selected from the group consisting of: H2N—C2H4—NH—C2H4—NH2, H2N—C2H4—NH—C2H4—NH—C2H4—NH2, H2N—(CH2)6—NH—(CH2)6—NH2, or tris(2-aminoethyl)amine is reacted with a ketone.Type: GrantFiled: August 31, 1999Date of Patent: March 5, 2002Assignee: The Boeing CompanyInventor: Larry K. Olli
-
Patent number: 6316478Abstract: This invention relates to novel spiro compound derivatives of benzoisothiazolyl-urea and -thiourea and compositions thereof. These compounds are useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).Type: GrantFiled: March 3, 2000Date of Patent: November 13, 2001Assignee: SmithKline Beecham CorporationInventors: Katherine L. Widdowson, Hong Nie
-
Patent number: 6294694Abstract: Peptoid compounds of Formula I and Formula II are disclosed The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.Type: GrantFiled: June 4, 1999Date of Patent: September 25, 2001Assignee: Wisconsin Alumni Research FoundationInventors: Donald T. Witiak, Paul J. Bertics, Yingsheng Zhang
-
Patent number: 6152968Abstract: The use of water-soluble quinacridones of the formula I ##STR1## where M.sup..sym. is a lithium, sodium, potassium or ammonium cation,R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently are hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, carboxyl, C.sub.1 -C.sub.4 -alkoxycarbonyl, sulfamoyl, mono- or di-(C.sub.1 -C.sub.4)-alkylsulfamoyl, carbamoyl, mono- or di-(C.sub.1 -C.sub.4)-alkylcarbamoyl, unsubstituted or substituted mono- or diphenylsulfamoyl, unsubstituted or substituted mono- or diphenylcarbamoyl, halogen, nitro or cyano,n is 0, 1 or 2 andm is 0, 1 or 2 and the sum n+m is at least 1,for dyeing and printing natural and synthetic fiber material.Type: GrantFiled: September 17, 1999Date of Patent: November 28, 2000Assignee: BASF AktiengesellschaftInventors: Karl-Heinz Etzbach, Carolin Kranz, Rudiger Sens
-
Patent number: 6140531Abstract: Describes a method of producing N-1-alkenyl carbonylamino compounds represented by the following general formula I, ##STR1## wherein R.sub.1 is the residue of an active hydrogen functional material, n is a number from 1 to a number equal to the number of active hydrogen groups of said active hydrogen functional material, X is selected from O, S and N(R.sub.5), R.sub.5 being hydrogen, hydrocarbyl, or R.sub.5 and R.sub.1 may together form a cyclic ring, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from hydrogen, C.sub.1 -C.sub.4 alkyl and C.sub.2 -C.sub.4 alkenyl.Type: GrantFiled: March 29, 1999Date of Patent: October 31, 2000Assignee: PPG Industries Ohio, Inc.Inventors: Cheruthur Govindan, John M. Pascone