Substituent Q Is Acyclic Patents (Class 564/95)
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Patent number: 5209966Abstract: This invention relates to an article comprising:(A) a polymer fabric treated with (B) a wetting agent which comprises at least one compound of the formula ##STR1##wherein R.sub.1 is a hydrocarbyl group having about 8 to about 150 carbon atoms; R.sub.2 is a hydrocarbylene group, or a hydroxy substituted or hydroxyalkyl substituted hydrocarbylene; each R.sub.3 is independently hydrogen, an alkyl group, a hydroxyalkyl group, a hydrocarbylcarbonyl or a polyoxyalkylene group; each R.sub.4 is independently a hydrocarbylene group; each n is independently 1 to 150; m is zero or one; m' is zero or one; M is a hydrogen, an ammonium cation or a metal cation, andwhen m' is zero, X is --H, --Ar, --OH, --OR.sub.5, ##STR2## when m' is one, X is --H, --R.sub.5, ##STR3##wherein each R.sub.5, R.sub.6 and R.sub.8 is independently a hydrocarbyl group having up to 100 carbon atoms; R.sub.7 is hydrogen or an alkyl group having from 1 to about 8 carbon atoms and Ar is a phenyl group.Type: GrantFiled: March 15, 1990Date of Patent: May 11, 1993Assignee: The Lubrizol CorporationInventors: Richard M. Lange, Arturs Grava
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Patent number: 5155271Abstract: The invention relates to a process for the preparation of compounds of the formula ##STR1## in which Q is substituted or unsubstituted C.sub.1 -C.sub.6 alkyl, A is a direct bond or a bridging member, s is the number 1 or 2, Z is a radical of the formula --CH.sub.2 CH.sub.2 OH, --CH.dbd.CH.sub.2 or --CH.sub.2 CH.sub.2 --Y, and Y is a leaving group, and the benzene or napthalene nucleus I can be further substituted, which comprises reacting compounds of the formula ##STR2## with compounds of the formulaQ--OH (3)in which A, s, Z and Q are as defined under formula (1), in the presence of hydrogenation catalysts, and then carrying out further conversion reactions where appropriate.The compounds obtained by the process according to the invention are suitable as intermediates for the preparation of reactive dyes.Type: GrantFiled: June 25, 1990Date of Patent: October 13, 1992Assignee: Ciba-Geigy CorporationInventor: Peter Aeschlimann
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Patent number: 5138067Abstract: Lipid derivatives represented by the formula: ##STR1## wherein R.sub.1 is alkyl or alkylcarbamoyl; R.sub.2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkyloxymethyl, lower alkylcarbonylmethyl, cyanomethyl, heterocyclic group, or heterocyclyloxy; R.sub.2 ' is hydrogen or R.sub.2 and R.sub.2 ' taken together with R.sub.2 form --O(CH.sub.2).sub.m -- wherein m is an integer of 1 to 5; R.sub.3, R.sub.4, and R.sub.5 each is hydrogen or lower alkyl or two or three of R.sub.3, R.sub.4, and R.sub.5 taken together with the adjacent nitrogen atom form cyclic ammonio; R.sub.6 is hydrogen or lower alkylcarbonyl; X.sup.- is a counter anion; Y is oxygen or sulfur; and n is an integer of 1 to 10, being useful as PAF antagonists, e.g., as antithrombotic, antivasoconstricting, antibronchoconstricting agent or antitumor agent.Type: GrantFiled: May 29, 1991Date of Patent: August 11, 1992Assignee: Shionogi & Co. Ltd.Inventors: Susumu Kamata, Tatsuo Tsuri, Nobuhiro Haga, Takeaki Matsui, Morio Kishi, Kimio Takahashi, Sanji Hagishita, Kaoru Seno
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Patent number: 5101072Abstract: Sulfonylhydrazines of the formula RSO.sub.2 N(CH.sub.2 CH.sub.2 X)N(SO.sub.2 CH.sub.3).sub.2, wherein R is an alkyl or an aryl and X is a halogen or OSO.sub.2 Y, wherein Y is an alkyl or an aryl. Such sulfonylhydrazines are useful in treating cancer.Methylating agents of the formula(a) R'SO.sub.2 N(CH.sub.3)N(SO.sub.2 CH.sub.3).sub.2, wherein R' is an alkyl or an aryl and(b) R"SO.sub.2 N(CH.sub.3)N(CH.sub.3)SO.sub.2 R", wherein R" is an alkyl or an aryl. Such methylating agents are useful as antitrypanosomal and anticancer agents.Type: GrantFiled: September 6, 1989Date of Patent: March 31, 1992Assignee: Yale UniversityInventors: Alan C. Sartorelli, Alan A. Divo, Krishnamurthy Shyam, Philip G. Penketh
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Patent number: 5079076Abstract: This invention relates to a composition prepared by reacting, in the presence of a redox initiator and a mineral acid,(a) at least one hydroxyl-containing imide, amide or mixtures thereof of a hydrocarbyl substituted carboxylic acid or anhydride having a hydrocarbyl group containing from about 8 to about 150 carbon atoms and a hydroxy amine; with(b) at least one sulfo compound represented by the following formula: ##STR1## wherein each R.sub.1 is independently hydrogen or a hydrocarbyl group; a is zero or one;Q is a hydrocarbylene group or --C(X)N(R.sub.2)Q'--;R.sub.2 is hydrogen or a hydrocarbyl group;X is sulfur or oxygen;Q' is a hydrocarbylene group; andZ is --S(O)OH, or --S(O).sub.2 OH or an ester, a metal salt or an ammonium salt of the sulfo compound.The invention also relates to polymer fabrics treated with the compositions of the present invention. The treated polymer fabrics have improved wicking/wetting characteristics.Type: GrantFiled: March 15, 1990Date of Patent: January 7, 1992Assignee: The Lubrizol CorporationInventor: Kasturi Lal
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Patent number: 5068427Abstract: A process for the preparation of alkane- and arenesulfonamides in high purity and yield is provided. Ammonia or alkylamine is reacted under boiling conditions with an alkane- or arenesulfonyl halide in the absence of an added solvent. The heat of reaction is dissipated by the heat of vaporization of the ammonia or alkylamine.Type: GrantFiled: November 16, 1989Date of Patent: November 26, 1991Assignee: Atochem North America, Inc.Inventors: Stanley R. Sandler, Steven G. Schon, David M. Gardner
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Patent number: 5015758Abstract: A process for the preparation of 1-adamantane derivatives characterized by the fact that a 1-acyloxyadamantane, in which the acyl group contains 1 to 4 carbon atoms, is reacted with a receptor compound in a linear aliphatic or cycloaliphatic type solvent in the presence of concentrated sulfuric acid and at ambient temperature.Type: GrantFiled: September 6, 1989Date of Patent: May 14, 1991Assignee: Centre International de Recherches Dermatologiques (CIRD)Inventors: William R. Pilgrim, Joel Lagiere
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Patent number: 4899249Abstract: A dielectric medium composition comprising a fluorine-containing amide or a fluorine-containing sulfonamide and capacitors or other electric devices incorporating said composition, are disclosed herein.Type: GrantFiled: April 21, 1988Date of Patent: February 6, 1990Assignee: Pennwalt CorporationInventors: James L. Reilly, Ludwig K. Huber, Gordon R. Leader
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Patent number: 4855286Abstract: The invention relates to compounds of the formula ##STR1## in which R.sup.1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification, and to their salts, to a process for their preparation, to pharmaceutical products containing them, and to their use as medicaments, and intermediates for the preparation of these compounds.Type: GrantFiled: July 28, 1987Date of Patent: August 8, 1989Assignee: Hoechst AktiengesellschaftInventors: Adalbert Wagner, Heinz-Werner Kleemann, Dieter Ruppert, Bernward Scholkens
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Patent number: 4845285Abstract: A process for preparing a compound of formula (II): ##STR1## or a tautomer or salt thereof in substantially pure form wherein R.sup.1 is C.sub.1-6 alkyl optionally substituted by one or more halogen atoms; R.sup.3 is hydrogen, fluorine, chlorine, bromine or iodine, C.sub.1-6 alkyl, trifluoromethyl or a cyano group; R.sup.4 is hydrogen, fluorine, chlorine, bromine, iodine or trifluoromethyl; R.sup.5 is fluorine, chlorine, bromine, iodine or trifluoromethyl; and R.sup.6 is hydrogen or C.sub.1-4 alkyl; which process comprises nitrating a compound of formula (III): ##STR2## or a salt thereof wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.Type: GrantFiled: November 25, 1987Date of Patent: July 4, 1989Assignee: Imperial Chemical Industries PLCInventors: Colin Hardy, Tony R. Martin, Jerzy Czyzewski, Daniel Levin
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Patent number: 4845129Abstract: The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated broncho-constriction and extravasation, PAF-induced hypotension, PAF-induced ischemic bowel disease and PAF-mediated, endotoxin induced lug injury.Type: GrantFiled: March 14, 1988Date of Patent: July 4, 1989Assignee: Sandoz Pharm. Corp.Inventors: Robert C. Anderson, William J. Houlihan, Howard C. Smith, Edwin B. Villhauer
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Patent number: 4816576Abstract: The invention relates to a sulphonic acid amidamine corresponding to the following general formula I: ##STR1## wherein R.sup.1 represents a C.sub.8 -C.sub.30 linear, saturated aliphatic hydrocarbon group or said group which is substituted by one or more chlorine atoms;R.sup.2 and R.sup.5 independently represent hydrogen or C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkyl which is substituted with one of the groups: hydroxyl, amino, mercapto, cyano, carboxyl or carbamoyl, and/or is interrupted by at least one oxy (--O--) or thio (--S--) group;R.sup.3 and R.sup.4 independently represent C.sub.2 -C.sub.13 alkylene or C.sub.5 -C.sub.7 cycloalkylene or said alkylene or cycloalkylene groups which are substituted with one of the groups: hydroxyl, amino, mercapto, cyano, carboxyl or carbamoyl;p represents zero or an integer of from 1 to 3;q represents zero or an integer of from 1 to 12; andn represents an integer of from 1 to 8.Type: GrantFiled: June 23, 1986Date of Patent: March 28, 1989Assignee: Bayer AkteingesellschaftInventors: Hans-Josef Buysch, Wolfgang Wellner, Hermann Gruber
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Patent number: 4780128Abstract: Diphenyl ethers of formula: ##STR1## wherein A is hydrogen or one of a specified range of substituents e.g. halogen, hydroxy, haloalkyl, B, C, E and F are hydrogen or specified substituents; D is CF.sub.3, halogen, or another specified substituent; and R is a group --CONR.sup.4 SO.sub.2 R.sup.3 wherein R.sup.4 is hydrogen or C.sub.1 to C.sub.4 alkyl and R.sup.3 is an optionally substituted alkyl, alkenyl, alkynyl, or aryl radical; useful as selective herbicides.Type: GrantFiled: August 28, 1986Date of Patent: October 25, 1988Assignee: Imperial Chemical Industries PLCInventor: David Cartwright
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Patent number: 4742069Abstract: Dihydropyridine derivatives of the formula ##STR1## wherein the symbols A, R and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as described herein.Compounds of formula I have a pronounced calcium-antagonistic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischemia, high blood pressure and/or migraine.Type: GrantFiled: June 17, 1985Date of Patent: May 3, 1988Assignee: Hoffmann-La Roche Inc.Inventors: Roland Jaunin, Henri Ramuz
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Patent number: 4692553Abstract: Cyclohexenone derivatives of the formula ##STR1## where R.sup.1 is hydrogen, methoxycarbonyl, ethoxycarbonyl, methyl or cyano, R.sup.2 is alkyl, R.sup.3 is alkyl, alkenyl, haloalkenyl, or propargyl, R.sup.4 is hydrogen or alkyl, R.sup.5 is hydrogen, alkyl, acyl, formyl, cycloalkylcarbonyl, methoxyalkylcarbonyl, unsubstituted or substituted benzoyl, alkoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl, alkylthiocarbonyl, N,N-dialkylcarbamyl, N-alkylcarbamyl, N-cycloalkylcarbamyl, N-alkoxy-N-alkylcarbamyl, unsubstituted or substituted N-phenylcarbamyl, alkylsulfonyl, alkenylsulfonyl, haloalkylsulfonyl, N-alkylsulfamyl, N,N-dialkylsulfamyl, N-acyl-N-alkylsulfamyl, N-alkyl-N-methoxycarbonylsulfamyl, dialkoxyphosphoryl, dialkoxythiophosphoryl, 2-haloalkanoyl, acyloxyacetyl or alkoxyoxalyl, and R.sup.6 is alkyl, halogen, hydroxyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, nitro or amino, and salts of these compounds, and the use of these compounds for controlling unwanted plant growth.Type: GrantFiled: July 26, 1985Date of Patent: September 8, 1987Assignee: BASF AktiengesellschaftInventors: Michael Keil, Ulrich Schirmer, Dieter Jahn, Rainer Becker, Bruno Wuerzer, Norbert Meyer
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Patent number: 4683330Abstract: A compound of the formula ##STR1## and intermediates useful in preparing same.Type: GrantFiled: January 11, 1985Date of Patent: July 28, 1987Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4672139Abstract: Benzoylurea compounds of the formula ##STR1## wherein the meaning of each of the symbols is described in the specification.Type: GrantFiled: July 21, 1986Date of Patent: June 9, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Martin Anderson
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Patent number: 4668814Abstract: A compound of the formula ##STR1## and intermediates useful in preparing same.Type: GrantFiled: January 11, 1985Date of Patent: May 26, 1987Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4654387Abstract: Compounds corresponding to the following general formula: ##STR1## wherein R.sup.0 represents H or, together with R.sup.1, represents --CO-- when X represents --CO-- or, together with R.sup.2, represents --CO-- when X represents --CH.sub.2 --CO,a residue of R, R.sup.1 and R.sup.2, H, C.sub.1 -C.sub.4 alkyl, aryl, COOR.sup.5 or, when R.sup.0 represents H and X represents --CO--, ##STR2## and the other residues R, R.sup.1 and R.sup.2 represent H; R.sup.3 represents H or CH.sub.3 ;R.sup.4 represents C.sub.7 -C.sub.20 aralkyl;R.sup.5 represents H, C.sub.1 -C.sub.4 alkyl or C.sub.6 -C.sub.12 aryl;X represents a residue --(CH.sub.2).sub.n CO--, --(CH.sub.2).sub.n SO.sub.2, --CH.sub.2 --, --CH.sub.2 O--CO-- ##STR3## m represents 1 or 2; and n represents 0 or 1;are suitable for use as incorporable antiagers for polymers, particularly nitrile rubber.Type: GrantFiled: August 7, 1985Date of Patent: March 31, 1987Assignee: Bayer AktiengesellschaftInventors: Hans-Josef Buysch, Zsolt Szentivanyi, Josef Witte
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Patent number: 4650902Abstract: The invention relates to new 2-ketosulfonamides of the formula ##STR1## and to a process for their preparation, wherein the reaction mixtures obtained by reacting enamines of the formula ##STR2## with sulfamoyl halides of the formula ##STR3## are hydrolyzed to the 2-ketosulfonamides.Type: GrantFiled: June 27, 1984Date of Patent: March 17, 1987Assignee: Hoechst AktiengesellschaftInventors: Albert Bender, Dieter Gunther, Lothar Willms, Rainer Wingen
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Patent number: 4628109Abstract: The invention relates to new 2-ketosulfonamides of the formula ##STR1## and to a process for their preparation, wherein the 3-amino-2-sulfamoylalk-2-enoic acid esters of the formula ##STR2## obtained by reacting 3-aminoalk-2-enoic acid esters of the formula ##STR3## with amidosulfonyl chlorides of the formula X-SO.sub.2 -NH-R.sup.2, are subjected to hydrolysis and decarboxylation. The invention also relates to the 3-amino-2-sulfamoylalk-2-enoic acid esters which can be isolated as intermediates.Type: GrantFiled: June 27, 1984Date of Patent: December 9, 1986Assignee: Hoechst AktiengesellschaftInventors: Erwin Schmidt, Dieter Gunther, Klaus-Dieter Kampe
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Patent number: 4604455Abstract: Mixtures of azoalkanes of varying thermal stabilities at least one of which is an unsymmetrical azoalkane (R--N.dbd.N--R'), are prepared by reacting 4 equivalents of a mixture of two or more primary alkyl, cycloalkyl or aralkylamines with 1 equivalent of sulfuryl chloride in an inert solvent and oxidizing the resulting mixture of sulfamide products with basic bleach. The unsymmetrical azoalkanes can be separated from the symmetrical azoalkanes by a variety of conventional techniques. The azoalkane mixtures are excellent polymerization initiators for vinyl monomers and curing agents for unsaturated polyester resins.Type: GrantFiled: December 14, 1984Date of Patent: August 5, 1986Assignee: Pennwalt CorporationInventor: Ronald E. MacLeay
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Patent number: 4589914Abstract: Herbicidally effective diphenyl ether compounds of the formula: ##STR1## where, for example, X is a halogen atom or a nitro group, R.sup.1 is a hydrogen atom or a chlorine, bromine or iodine atom, and R.sup.2 is a group --OR.sup.3 wherein R.sup.3 is an alkyl group containing from 1 to 12 carbon atoms.Type: GrantFiled: March 27, 1984Date of Patent: May 20, 1986Assignee: Imperial Chemical Industries PLCInventor: David Cartwright
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Patent number: 4581178Abstract: Low valent transition metal complexes containing small cone angle phosphine or arsine ligands efficiently catalyze addition of aldehydes to compounds or groups having a C--H bond activated by a nitro or nitrile group, to provide nitroalcohols or cyanohydrins, respectively.Type: GrantFiled: February 28, 1985Date of Patent: April 8, 1986Assignee: E. I. Du Pont de Nemours and CompanyInventor: David Milstein
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Patent number: 4567004Abstract: Monomethyl-substituted methylene compounds are obtained by reacting methylene compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 independently of one another represent --CN, --CO--R.sup.3, --SO.sub.2 --R.sup.3 or --NO.sub.2 andR.sup.1 can additionally denote -aryl(R.sup.1).sub.n,whereinR.sup.3 denotes --OH, alkyl, aralkyl, aryl, alkoxy, aralkoxy or aryloxy, or amino which is substituted by alkyl and/or aralkyl and/or aryl, and furthermoretwo radicals R.sup.3 together can be an alkylene group, the radical of an aliphatic diol or of an aliphatic diamine or the group --NH--CO--NH-- and n represents 1, 2 or 3,with formaldehyde and with hydrogen in the presence of a condensation catalyst and a hydrogenation catalyst at elevated temperature, the methylene compound being introduced into the liquid phase of the mixture of reactants in the course of the reaction.Type: GrantFiled: July 18, 1984Date of Patent: January 28, 1986Assignee: Bayer AktiengesellschaftInventors: Heinz U. Blank, Erich Wolters
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Patent number: 4511735Abstract: The present invention relates to novel fungicides of the formula: ##STR1## wherein R.sup.1 is lower alkyl, lower akenyl, lower alkynyl or aryl of 6 to 10 carbon atoms optionally substituted with up to 3 halogen atoms; R.sup.2 is lower alkyl, lower alkenyl, lower alkynyl or aryl of 6 to 10 carbon atoms optionally substituted with up to 3 halogen atoms or up to 3 lower alkoxy groups; and R.sup.3 is alkyl of 1 to 3 carbon atoms substituted with 3 to 6 halogen atoms or trihalovinyl.Type: GrantFiled: September 30, 1983Date of Patent: April 16, 1985Assignee: Chevron Research CompanyInventor: Philip S. Magee
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Patent number: 4505859Abstract: 2-Haloethylamides are prepared by reaction of 2-oxazolidinone or C.sub.1-6 alkyl or phenyl derivatives thereof with an acid halide.Type: GrantFiled: October 9, 1981Date of Patent: March 19, 1985Assignee: The Dow Chemical CompanyInventor: Graham S. Poindexter
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Patent number: 4504305Abstract: A compound having the general formula ##STR1## wherein R.sub.1 is alkyl having 1-3 carbon atoms;R.sub.2 is alkyl having 1-3 carbon atoms, allyl, propargyl or haloalkenyl; andA is selected from the group consisting of ##STR2## wherein R.sub.3 is --SO.sub.2 R.sub.6 group, ##STR3## R.sub.4 is hydrogen, alkyl having 1-6 carbon atoms; phenyl or halophenyl; R.sub.5 is alkyl having 1-3 carbon atoms; X is oxygen or sulfur; and n is 0 or 1; wherein R.sub.6 is alkyl having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms or propenyl; R.sub.7 is hydrogen or alkyl having 1-4 carbon atoms; R.sub.8 is hydrogen, alkyl having 1-6 carbon atoms; propenyl or methoxy; R.sub.9 is hydrogen, alkyl having 1-8 carbon atoms, haloalkyl having 1-3 carbon atoms, alkoxy having 1-6 carbon atoms, propenyl or phenyl substituted with methyl; and Y and Z are oxygen or sulfur; and a metal salt or a quaternary ammonium salt of a compound defined herein above.The compound is useful as a herbicide.Type: GrantFiled: December 27, 1982Date of Patent: March 12, 1985Assignee: Nippon Soda Co., Ltd.Inventors: Isao Iwataki, Akira Nakayama, Minoru Kaeriyama, Hisao Ishikawa, Hideo Hosaka, Kenichi Kohara
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Patent number: 4486598Abstract: Novel compounds of the following general formula: ##STR1##Type: GrantFiled: February 22, 1982Date of Patent: December 4, 1984Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4465508Abstract: Diphenyl ethers of formula: ##STR1## wherein A is hydrogen or one of a specified range of substituents e.g. halogen, hydroxy, haloalkyl, B, C, E and F are hydrogen or specified substituents; D is CF.sub.3, halogen, or another specified substituent; and R is a group --CONR.sup.4 SO.sub.2 R.sup.3 wherein R.sup.4 is hydrogen or C.sub.1 to C.sub.4 alkyl and R.sup.3 is an optionally substituted alkyl, alkenyl, alkynyl, or aryl radical; useful as selective herbicides.Type: GrantFiled: April 28, 1982Date of Patent: August 14, 1984Assignee: Imperial Chemical Industries PLCInventors: John E. D. Barton, David J. Collins, John M. Cox, David A. Griffin, David R. Parry, David Cartwright
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Patent number: 4448988Abstract: The invention relates to new 2-ketosulfonamides of the general formula ##STR1## and to a process for their preparation, which process comprises oxidizing compounds of the general formulaR--CHOH--CH.sub.2 --SO.sub.2 NH.sub.2with manganese dioxide in a readily volatile, oxidation-stable organic solvent, preferably acetone or acetonitrile.Type: GrantFiled: April 21, 1982Date of Patent: May 15, 1984Assignee: Hoechst AktiengesellschaftInventor: Dieter Gunther
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Patent number: 4401663Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is ##STR2## wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is H, OH or OCH.sub.3, and wherein R.sub.2 is OH or H, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These sulfonamides have analgesic and anti-irritant activity when administered to humans and lower animals.Type: GrantFiled: March 23, 1982Date of Patent: August 30, 1983Assignee: The Procter & Gamble CompanyInventors: Brian L. Buckwalter, Thomas R. LaHann
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Patent number: 4355036Abstract: Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3 or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring, ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is ##STR6## wherein p is 1 or 2 and n is 1 or 2, R.sup.1 is C.sub.1 to C.sub.6 alkyl, R.sup.2 is hydrogen or C.sub.1 to C.sub.6 alkyl, and the dotted line represents an optical double bond, R.sup.2 being absent if the double bond is present, and Y is substituted carboxylate or substituted sulfonyl. Said antihistamines have little or no sedative effects.Type: GrantFiled: March 16, 1981Date of Patent: October 19, 1982Assignee: Schering CorporationInventor: Frank J. Villani
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Patent number: 4352760Abstract: The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A.sub.2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.Type: GrantFiled: December 29, 1980Date of Patent: October 5, 1982Assignee: The Upjohn CompanyInventor: Kirk M. Maxey
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Patent number: 4349690Abstract: The present invention provides novel 9-deoxy-9-methylene-6-keto-PGE derivatives which are useful for platelet aggregation inhibition and gastric cyctoprotection.Type: GrantFiled: April 23, 1981Date of Patent: September 14, 1982Assignee: The Upjohn CompanyInventor: Gordon L. Bundy
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Patent number: 4349689Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: September 14, 1982Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4306076Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: December 15, 1981Assignee: The Upjohn CompanyInventor: Norman A. Nelson
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Patent number: 4306075Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: December 15, 1981Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4298522Abstract: A diphenylamine derivative of the general formula ##STR1## wherein R represents a hydrogen atom or a methyl group, R.sub.1 and R.sub.2, independently from each other, represent a hydrogen atom, a chlorine atom, a bromine atom, or a hydrocarbon radical having 1 to 12 carbon atoms, and A represents ##STR2## and a degradation inhibitor for rubbery polymers comprising the aforesaid diphenylamine derivative as an active ingredient.Type: GrantFiled: June 19, 1980Date of Patent: November 3, 1981Assignee: Nippon Zeon Co. Ltd.Inventors: Mitsuhiro Tamura, Tetsuo Ohishi, Hiroshi Sakurai
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Patent number: 4289904Abstract: The present invention provides novel 19-hydroxy-6a-carba-PGI.sub.2 sulfonylamides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.Type: GrantFiled: March 3, 1980Date of Patent: September 15, 1981Assignee: The Upjohn CompanyInventor: John C. Sih
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Patent number: 4281150Abstract: The present invention provides novel 19-hydroxy-19-methyl-6a-carba-PGI.sub.1 sulfonylamides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.Type: GrantFiled: March 3, 1980Date of Patent: July 28, 1981Assignee: The Upjohn CompanyInventor: John C. Sih
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Patent number: 4276436Abstract: The present invention provides novel 19-keto-PG sulfonylamides, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.Type: GrantFiled: March 20, 1980Date of Patent: June 30, 1981Assignee: The Upjohn CompanyInventor: John C. Sih
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Patent number: 4268669Abstract: The present invention particularly relates to novel 9-deoxy-9-methylene-5,6-didehydro-PGF.sub.1 amides and methods for their preparation in pharmacological use.Type: GrantFiled: January 28, 1980Date of Patent: May 19, 1981Assignee: The Upjohn CompanyInventor: Gordon L. Bundy
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Patent number: 4267352Abstract: The present invention provides novel 19-hydroxy-19-methyl-6-oxo-PGF.sub.1 sulfonylamides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.Type: GrantFiled: March 3, 1980Date of Patent: May 12, 1981Assignee: The Upjohn CompanyInventor: John C. Sih
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Patent number: 4264522Abstract: The present invention provides novel 19-hydroxy-PG amides methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.Type: GrantFiled: October 26, 1979Date of Patent: April 28, 1981Assignee: The Upjohn CompanyInventor: John C. Sih
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Patent number: 4263206Abstract: Dyestuffs are provided which contain one or more 1,3-dicyanobenzene radicals linked to the dyestuff at the 2-, 4- or 6-position, with halogen substituents in both of the remaining two of these positions and an electron-attracting substituent in the 5-position. These dyestuffs reactively dye cellulose at low temperatures and are less prone to "acid-bleeding" than some known reactive dyes. More particularly, those dyestuffs have the formula: ##STR1## where D is a chromophoric groupn is 1 or 2, ##STR2## where R is H, C.sub.1-4 alkyl, C.sub.1-4 alkyl substituted by OH, OSO.sub.3 H, CN or SO.sub.3 H or is phenyl.Each hal independently represents a chlorine or fluorine atom occupying one of the remaining 2-, 4- and 6-positions of the benzene nucleus, and Y is H, F, Cl, CN, NO.sub.2 or SO.sub.3 H.Type: GrantFiled: March 12, 1979Date of Patent: April 21, 1981Assignee: Imperial Chemical Industries LimitedInventor: Brian Anderson
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Patent number: 4252978Abstract: The present invention provides novel 19-hydroxy-6-oxo-PGF.sub.1 sulfonylamides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.Type: GrantFiled: March 3, 1980Date of Patent: February 24, 1981Assignee: The Upjohn CompanyInventor: John C. Sih