And Sulfur Or Oxygen Bonded Indirectly To Phosphorus Patents (Class 568/15)
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Publication number: 20100029593Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.Type: ApplicationFiled: September 4, 2009Publication date: February 4, 2010Inventors: YVES CLAUDE NICOLAU, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
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Publication number: 20100010249Abstract: The principal object of the invention is to provide a lithium salt having excellent ion conductivity. The invention solves the problem by providing a lithium salt having a structure represented by the general formula (1): in which “M” represents B, Si, Ge, P, As or Sb; “X” represents the valence of “M”; “R1” represents —CmH2m— whereupon “m” is an integer of 1 to 4; “R2” represents —CkH2k+1 whereupon “k” is an integer of 1 to 8; and “n” represents 0 to 12.Type: ApplicationFiled: September 13, 2007Publication date: January 14, 2010Inventors: Tatsuo Fujinami, Ruoyuan Tao, Masaki Matsui
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Publication number: 20090274972Abstract: An electrostatic-image-developing toner includes a phosphonic acid based sequestering agent.Type: ApplicationFiled: December 15, 2008Publication date: November 5, 2009Applicant: FUJI XEROX CO., LTD.Inventors: Shuji SATO, Eisuke IWAZAKI, Atsushi SUGAWARA, Masanobu NINOMIYA, Hiroshi NAKAZAWA
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Publication number: 20090216003Abstract: The present invention describes a flexible basestacking monomer that can be incorporated into an oligonucleotide or oligonucleotide analogue, as well as triplex forming oligonucleotides comprising the flexible basestacking monomer. Triplex forming oligonucleotides of the invention are capable of binding sequence specifically to doublestranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.Type: ApplicationFiled: May 24, 2006Publication date: August 27, 2009Inventors: Vyachelsav V Filichev, Erik Bjerregaard Pedersen
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Publication number: 20090203648Abstract: A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: ApplicationFiled: April 14, 2009Publication date: August 13, 2009Applicants: Centre National de la Recherche Scientifique, Universite de Nantes, Institut National de la Sante et de la Recherche MedicaleInventors: Bruno Bujoli, Solen Josse, Jerome Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
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Publication number: 20090197201Abstract: The present invention relates to the use of end groups Y, where Y stands for (formula I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)r—, [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, as end group in surface-active compounds, to corresponding novel compounds, and to processes for the preparation of these compounds.Type: ApplicationFiled: July 2, 2007Publication date: August 6, 2009Inventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev, Martin Seidel, Elvira Montenegro, Peer Kirsch, Andreas Bathe
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Publication number: 20090198038Abstract: The present invention relates to metal/organic complexes of Formula (I), (II), (III), (IV), (V) and (VI) that are useful as catalysts for the polymerisation of carbonyl-containing or cyclic monomers. Typical polymerisation reactions are, for example, those of lactides. R is independently selected at each occurrence from the group comprising: hydrogen, hydrocarbyl and substituted hydrocarbyl, M is a Lewis-acidic metal, and, if present, X is any suitable counter ion.Type: ApplicationFiled: June 21, 2007Publication date: August 6, 2009Applicant: THE UNIVERSITY OF NOTTINGHAMInventor: Polly Arnold
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Publication number: 20090186790Abstract: The present invention relates to photo-labile pro-fragrance conjugates comprising: a) a photo-labile unit which upon exposure to electromagnetic radiation is capable of releasing a pro-fragrance unit; and b) a pro-fragrance unit, which when so released is either i) a pro-fragrance compound capable of releasing a fragrance raw material; or ii) a fragrance raw material. The present invention relates to systems for delivering fragrances to a situs, and to laundry detergent compositions, fine fragrances, personal care and hair care compositions comprising said systems.Type: ApplicationFiled: March 26, 2009Publication date: July 23, 2009Inventors: Robert Richard Dykstra, Gregory Scot Miracle, Lon Montgomery Gray
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Publication number: 20090142672Abstract: The present invention provides an optical recording composition comprising a compound denoted by general formula (I) and a holographic recording medium comprising a recording layer, wherein the recording layer comprises a compound denoted by general formula (I). In general formula (I), each of R1, R2, and R3 independently denotes an alkyl group, aryl group, or heterocyclic group, X denotes an oxygen atom or sulfur atom, and n denotes 0 or 1.Type: ApplicationFiled: November 21, 2008Publication date: June 4, 2009Applicant: FUJIFILM CorporationInventor: Satoru YAMADA
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Publication number: 20090118236Abstract: The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.Type: ApplicationFiled: November 19, 2004Publication date: May 7, 2009Inventors: Mark D. Erion, Hongjian Jiang, Serge H. Boyer
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Publication number: 20090105361Abstract: A compound that exhibits excellent color tone stability and physical properties as well as excellent photopolymerization activity over a wide region from near-ultraviolet to visible region, permitting relaxed operation under ambient light, so that wide application can be found in the dental field and photopolymerization industry; and a relevant photopolymerization initiator and hardenable composition. In particular, there is provided a novel camphorquinone derivative having an acylphosphine oxide group [—(C?O)—(P?O)<] in each molecule. Further, there is provided a photopolymerization initiator comprising the camphorquinone derivative having an acrylphosphine oxide group [—(C?O)—(P?O)<] in each molecule as an indispensable component, loaded with at least one member selected from among a polymerization accelerator, a photoacid generator, a photosensitizer and a (bis)acylphosphine oxide, and provided a hardenable composition comprising the initiator.Type: ApplicationFiled: March 13, 2006Publication date: April 23, 2009Inventors: Kunio Ikemura, Kensuke Ichizawa, Yoshiyuki Jogetsu
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Publication number: 20090087492Abstract: The present invention relates to a process, for the production of crystalline particles of an active organic compound The process includes the steps of generating a micro-seed by a wet-milling process and subjecting the micro-seed to a crystallization process. The resulting crystalline particles have a mean particle size of less than about 100 ?m. The present invention also provides for a pharmaceutical composition which includes the crystalline particles produced by the method described herein and a pharmaceutically acceptable carrier.Type: ApplicationFiled: March 12, 2007Publication date: April 2, 2009Applicant: MERCK & CO., INC.Inventors: Brian K. Johnson, Hsien Hsin Tung, Ivan Lee, Aaron S. Cote, Cindy Starbuck, Michael Midler
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Publication number: 20090062568Abstract: A novel process for preparing in a high purity and in a high yield phosphonates having a secondary and/or tertiary alcoholic hydroxyl group at the end of a P—C bond chain thereof with the use of a phosphite and a carbonyl compound as raw materials.Type: ApplicationFiled: October 18, 2005Publication date: March 5, 2009Applicant: DAIHACHI CHEMICAL INDUSTRY CO., LTD.Inventors: Makoto Kyoda, Manabu Hirata
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Publication number: 20090028925Abstract: The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.Type: ApplicationFiled: May 26, 2006Publication date: January 29, 2009Inventors: Mark D. Erion, Hongjian Jiang, Serge H. Boyer
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Publication number: 20090023579Abstract: Disclosed is a novel asymmetric ligand which can be synthesized by a short process at low cost and is capable of exhibiting higher catalytic activity and enantioselectivity than the conventional ligands derived from sugars. Also disclosed are a method for producing such an asymmetric ligand, and a catalyst using such an asymmetric ligand. Specifically disclosed is a ligand represented by the general formula I below or the like. (In the formula, R1 and R2 independently represent 0-5 substituents; X represents P, As or N; m represents an integer of 0-7; n represents an integer of 0-3; A1-A4 independently represent hydrogen, fluorine, chlorine, bromine, benzoyl or acetyl, or alternatively A2 and A3 combine together to form a ring.Type: ApplicationFiled: March 2, 2007Publication date: January 22, 2009Applicant: THE UNIVERSITY OF TOKYOInventors: Masakatsu Shibasaki, Motomu Kanai, Ikuo Fujimori, Kenzo Yamatsugu, Shin Kamijo
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Publication number: 20080318227Abstract: The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.Type: ApplicationFiled: August 30, 2007Publication date: December 25, 2008Inventors: Adelbert Bacher, Felix Rohdich, Petra Adam, Sabine Amslinger, Wolfgang Eisenreich, Stefan Hecht
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Publication number: 20080319231Abstract: The invention relates to a new process for the production of alkyl dialkoxyalkylphosphinates. A hypophosphite salt is used in the process.Type: ApplicationFiled: September 12, 2005Publication date: December 25, 2008Inventors: Maths Nilsson, Mats Thelin, Johanna Wachtmeister
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Publication number: 20080300427Abstract: A process for producing a compound of the formula: including reacting of a compound of the formula: with diphenyl phosphine oxide using a binary phase reaction mixture including diphenyl phosphine oxide in an organic solvent, a basic aqueous solution, and a phase transfer catalyst, to obtain the compound of formula 1, wherein Ph is phenyl, X1 and X2 are both hydrogen or X1 and X2 taken together are CH2, R1 is a protecting group, R2 is fluorine, hydrogen, or OR3, wherein R3 is a protecting group, and the squiggly line represents a bond that results in the adjacent double bond being in either the E or Z configuration, is disclosed.Type: ApplicationFiled: May 29, 2008Publication date: December 4, 2008Inventor: Uttam Saha
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Publication number: 20080297044Abstract: A metal sulfide nanocrystal manufactured by a method of reacting a metal precursor and an alkyl thiol in a solvent, wherein the alkyl thiol reacts with the metal precursor to form the metal sulfide nanocrystals, wherein the alkyl thiol is present on the surface of the metal sulfide nanocrystal, wherein the alkyl thiol is bonded to the sulfur crystal lattice. A metal sulfide nanocrystal manufactured with a core-shell structure by a method of reacting a metal precursor and an alkyl thiol in a solvent to form a metal sulfide layer on the surface of a core, wherein the alkyl thiol is present on the surface of the metal sulfide nanocrystal, wherein the alkyl thiol is bonded to the sulfur crystal lattice. These metal sulfide nanocrystals can have a uniform particle size at the nanometer-scale level, selective and desired crystal structures, and various shapes.Type: ApplicationFiled: July 17, 2008Publication date: December 4, 2008Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Shin Ae Jun, Eun Joo Jang, Seong Jae Choi
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Patent number: 7446228Abstract: Disclosed is a thiosphosphine compound of formula: wherein X represents with R1 being H or —CH3, R and R? represent, independently from each other, an alkyl radical, an alkoxy radical, an aryl radical or a phenyl radical which may be substituted with one or more alkyl and/or alkoxy groups, n is an integer from 0 to 4, n? is an integer from 0 to 5, x is an integer from 0 to 2, y is an integer from 1 to 5 with the proviso that y+n is an integer from 1 to 5. The compounds can be used to make optically transparent articles such as ophthalmic lenses.Type: GrantFiled: October 20, 2006Date of Patent: November 4, 2008Assignee: Essilor International Compagnie Generale d'OptiqueInventors: Sirisoma Wanigatunga, Aref Jallouli, Martin Rickwood, Yassin Yusef Turshani
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Patent number: 7439401Abstract: The present invention relates to a new, selective process for the preparation of mono- and bisacylphosphanes of formula (I) n and m are each independently of the other 1 or 2; R1, if n=1, is e.g. phenyl R1, if n=2, is e.g. C1-C18alkylene or phenylene; R2 is e. g. C1-C18alkyl, phenyl or substituted phenyl; R3 is e. g. C1-C18alkyl, by (1) reacting a phosphorous halide of formula IIa or a phosphorous halide oxide of formula (IIb) or a phosphorous halide sulfide of formula (IIc) with an alkali metal in a solvent in the presence of a proton source; (2) subsequent reaction with m acid halides of formula (III) An oxidation step may follow to obtain mono- and bisacylphosphane oxides or mono- and bisacylphosphane sulfides.Type: GrantFiled: July 9, 2004Date of Patent: October 21, 2008Assignee: Ciba Specialty Chemicals CorporationInventors: Reinhard H. Sommerlade, Souâd Boulmaâz, Jean-Pierre Wolf, Jens Geier, Hansjörg Grützmacher, Markus Scherer, Hartmut Schönberg, Daniel Stein, Peter Murer, Stephan Burkhardt
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Publication number: 20080255287Abstract: Compounds having the formulas below. Each R1 is an aromatic-containing group. Each R2 is methyl, phenyl, alkyl, perfluoroalkyl, and trifluoromethyl. M is an alkali metal, and n is a positive integer. A thermoset made by curing a mixture comprising a curing agent and the below phthalonitrile monomer. A method of: reacting a bis(fluorophenyl)phenylphosphine oxide with an excess of an aromatic diol in the presence of an alkali metal carbonate to form the oligomer below.Type: ApplicationFiled: September 7, 2007Publication date: October 16, 2008Applicant: The Government of the US, as represented by the Secrectary of the NavyInventors: Matthew Laskoski, Teddy M. Keller
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Publication number: 20080221675Abstract: Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization.Type: ApplicationFiled: May 22, 2008Publication date: September 11, 2008Applicant: ALCON, INC.Inventor: Douglas C. Schlueter
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Publication number: 20080214708Abstract: The invention relates to asymmetrically substituted phosphinic acids of the formula (I) R1R2C(OH)—P(?O)(OX)—C(OH)R3R4 ??(I) in which X is hydrogen R1, R2, R3, and R4 are identical or different and are hydrogen, alkyl, alkenyl, alkynyl, aralkyl, aryl and/or alkaryl, with the proviso that the respective R1R2C(OH)— and —C(OH)R3R4 groups are always different, to a process for their preparation, and to their use.Type: ApplicationFiled: September 28, 2007Publication date: September 4, 2008Inventors: Harald Bauer, Michael Hill, Werner Krause
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Publication number: 20080183018Abstract: The present invention relates to oligomeric or polymer dithiophosphate di- or poly-sulfides and their utility in rubbers. Another aspect of the invention is a method for making oligomeric or polymeric dithiophosphates by reacting phosphorous pentasulfide with a di- or polyol and a mono alcohol to produce a dithiophosphoric acid, and then oxidizing the dithiophosphoric acid with an oxidizing agent to produce an oligomeric or polymeric dithiophosphate.Type: ApplicationFiled: January 31, 2008Publication date: July 31, 2008Applicant: R.T. VANDERBILT COMPANY, INC.Inventors: Thomas J. Karol, Ronald J. Tepper
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Publication number: 20080178433Abstract: Processes for the preparation, concentration and recovery an N-(phosphonomethyl)glycine product from aqueous process streams including contacting mother liquor generated in the precipitation of N-(phosphonomethyl)glycine product crystals with a selective membrane to produce a retentate enriched N-(phosphonomethyl)glycine product and a permeate depleted in N-(phosphonomethyl)glycine product are disclosed.Type: ApplicationFiled: January 31, 2007Publication date: July 31, 2008Applicant: MONSANTO TECHNOLOGY LLCInventors: Sunder Rangachari, Ed Ries, Eduardo Casanova, Randall Alberts, Todd Friedman, Greg Hartmann
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Patent number: 7385064Abstract: Disclosed are compounds having the following formula: in which Z11 is selected from a substituted or unsubstituted saturated adamantyl or other polycyclic group and a substituted or unsubstituted branched acyclic group containing at least 5 carbon atoms at least one of which is a tertiary carbon; and in which Z12 is a cyclic imide. Methods of using these compounds as chiral catalysts for carbenoid reactions and for enantioselective C—H aminations are also described.Type: GrantFiled: November 30, 2006Date of Patent: June 10, 2008Assignee: The Research Foundation of State University of New YorkInventors: Huw M. L. Davies, Ravisekhara P. Reddy
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Patent number: 7378556Abstract: Disclosed is a process for making a thiophosphine compound of formula (I): wherein X represents SH or with R1 being H or —CH3, R and R? represent, independently from each other, an alkyl radical, an alkoxy radical, an aryl radical or a phenyl radical which may be substituted with one or more alkyl and/or alkoxy groups, n is an integer from 0 to 4, n? is an integer from 0 to 5, x is an integer from 0 to 2, y is an integer from 1 to 5 with the proviso that y+n is an integer from 1 to 5, wherein y =1, X is in para position with regard to phosphorus and represents SH.Type: GrantFiled: October 20, 2006Date of Patent: May 27, 2008Assignee: Essilor International Compagnie Generale d'OptiqueInventors: Sirisoma Wanigatunga, Aref Jallouli, Martin Rickwood, Yassin Yusef Turshani
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Publication number: 20080071116Abstract: The present invention provides phosphoric acid and phosphoric acid compounds as well as thioderivatives thereof of formulat (I, II, III, IV and V).Type: ApplicationFiled: December 15, 2004Publication date: March 20, 2008Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Yutaka Hasegawa, Gordon Mills
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Publication number: 20070210288Abstract: The invention relates to mixtures composed of dialkylphosphinic esters and of further components, which comprise A) from 98 to 100% by weight of monocarboxy-functionalized dialkylphosphinic esters of the formula (I) in which R1, R2, R3, R4, R5, R6, and R7 are identical or different and, independently of one another, are H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, and/or phenyl, Y is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl, 2-hydroxyethyl, 2,3-dihydroxypropyl, 2-hydroxypropyl, 3-hydroxypropyl, 4-hydroxybutyl, 3-hydroxybutyl, 2-hydroxybutyl, and/or 6-hydroxyhexyl, allyl, and/or glycerol, X is H, Li, Na, K or NH4, or X is defined as for Y, and then X and Y are two identical radicals or two different radicals of the above organic radicals, and B) from 0 to 2% by weight of halogens, where the entirety of the components always amounts to 100% by weight.Type: ApplicationFiled: March 6, 2007Publication date: September 13, 2007Inventors: Wiebke Maas, Werner Krause, Harald Bauer
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Patent number: 7196228Abstract: The invention relates to dimer and multimer form of BAPO compounds of the formula (I) dimer and multimer forms of MAPO compounds of the formula (II) wherein R1, R2, and R3 independently of one another are unsubstituted or substituted C1–C12alkyl, benzyl, C1–C12alkoxy, C3–C6cycloalkyl or C5–C14aryl; Q is a di- tri or tetravalent arylene residue; n is 1–4, m is 0–2, n+m is 2, 3 or 4, with the proviso, that R1 and R3 are different from each other.Type: GrantFiled: June 3, 2003Date of Patent: March 27, 2007Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Pierre Wolf, Gebhard Hug
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Patent number: 7129367Abstract: Palladum-phosphine complexes obtained by reacting a 5 compound of formula (1) below with a palladium compound: F(I) (wherein R1 is a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R2 and R3 are each, the same or different, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R4 and R5 are each, the same or different, a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R6, R7, R8 and R9 are each, the same or different, an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, an alkoxyl group, a dialkylamino group, a halogen atom, a phenyl group, a benzyl group, a naphthyl group or a halogenated alkyl group; R6 and R7, R8 and R9 may be combined to form, each, a fused ring, a trimethylene group, a tetramethylene group or a 20 methylenedioxy group; p, q, r and s are each an integer of 0 to 5; and p+q, and r+s are each in the range of 0 to 5.Type: GrantFiled: February 12, 2004Date of Patent: October 31, 2006Assignee: Takasago International CorporationInventors: Ken Suzuki, Yoji Hori
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Patent number: 7112692Abstract: A method for making ?-ketophosphonates by reacting a trialkyl phosphonocarboxylate (such as triethyl phosphonoacetate) with an acyl halide (such as acetyl chloride) in a reaction involving ester formation, followed by decarboxylation, followed by purification. The reaction is run in a single solvent, which is not removed from the reaction mixture until the purification stage. Suitable solvents for this purpose include halogenated aromatic hydrocarbons (such as mono-chlorobenzene).Type: GrantFiled: August 23, 2002Date of Patent: September 26, 2006Assignee: Rhodia Consumer Specialties, LimitedInventors: Christopher John Harris, Alan Craig Smith, Julie Ann Salter
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Patent number: 7109286Abstract: A phosphorus-containing hydroquinone derivative represented by a general formula (1): (where R1 and R2 represent linear or branched alkyl groups that are identical or may be different, and/or R1 and R2 may form a circular group; X represents an oxygen atom or sulfur atom; Y and Z represent hydrogen atom, hydroxy group, linear or branched alkyl group, aralkyl group, alkoxy group, allyl group, aryl group or cyano group, and/or Y and Z may form a circular group). The present invention provides phosphorus-containing hydroquinone derivatives that are useful for intermediate materials for reactive type flame-retardant agents or phosphorus-containing epoxy resins.Type: GrantFiled: June 20, 2001Date of Patent: September 19, 2006Assignee: Nippon Chemical Industrial Co., Ltd.Inventors: Ken Tamura, Eiichi Tatsuya, Yoshirou Kaneda, Natsuhiro Sano
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Patent number: 7109250Abstract: Compounds of the formula (I), in which E is O or S; and x is 0 or 1, A is cyclopentyl, cyclohexyl, naphthyl, biphenylyl, anthracyl or an O-, S- or N-containing 5- or 6-membered heterocyclic ring, where the mentioned radicals are unsubstituted or substituted by halogen, C1–C4alkyl or C1–C4alkoxy; or A is a group formula (II) R is C1–C24alkyl, unsubstituted or substituted, C2–C24alkyl which is interrupted once or more than once by nonconsecutive O, S or NR14 and which is unsubstituted or substituted, C2–C24alkenyl which is uninterrupted or interrupted once or more than once by nonconsecutive O, S or NR14 and which is unsubstituted or substituted, C5–C24cycloalkenyl which is uninterrupted or interrupted once or more than once by nonconsecutive O, S or NR14 and which is unsubstituted or substituted; C7–C24arylalkyl which is unsubstituted or substituted on the aryl group.Type: GrantFiled: November 13, 2002Date of Patent: September 19, 2006Assignee: Ciba Specialty Chemicals Corp.Inventors: Jean-Pierre Wolf, Gebhard Hug
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Patent number: 7094931Abstract: A description is given of processes for the preparation of mono- and bisacylphosphines and of mono- and bisacylphosphine oxides and mono- and bisacylphosphine sulfides, which comprises first reacting organic P-monohalogenophosphines or P,P-dihalogenophosphines, or mixtures thereof, with an alkali metal or magnesium in combination with lithium, where appropriate in the presence of a catalyst, and then carrying out the reaction with acid halides and, in the case of the process for the preparation of oxides, carrying out an oxidation step and, in the case of the preparation of sulfides, reacting the phosphines so obtained with sulfur. It is characteristic, inter alia, that the processes are carried out without isolation of the intermediates.Type: GrantFiled: May 17, 2004Date of Patent: August 22, 2006Assignee: Ciba Specialty Chemicals CorporationInventors: David George Leppard, Eugen Eichenberger, René´ Kaeser, Gebhard Hug, Urs Schwendimann
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Patent number: 7067701Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P-L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P-L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.Type: GrantFiled: January 15, 2004Date of Patent: June 27, 2006Assignee: SRI InternationalInventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Ursula Eilenberg-Robben, legal representative, Wolf Eilenberg, deceased
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Patent number: 7026017Abstract: Compounds of the formula I in which Ar is a group or unsubstituted or substituted cyclopentyl, cyclohexyl, naphthyl, biphenylyl or an O-, S- or N-containing 5- or 6-membered heterocyclic ring; R1 and R2 are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 are hydrogen, C1-C20alkyl, OR11 or halogen; R6 is unsubstituted or substituted C1-C24alkyl, C2-C24alkyl, which is interrupted by O, S or NR14 and is unsubstituted or substituted; C2-C24alkenyl, uninterrupted or interrupted by O, S or NR14 and unsubstituted or substituted; unsubstituted or substituted C7-C24arylalkyl; C4-C24cycloalkyl, uninterrupted or interrupted by O, S and/or NR14; or C8-C24arylcycloalkyl; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O or S and unsubstituted or substituted; R12 and R13 are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O atoms and unsubstituted or substituted; or R12 and R13 together are C3-C5alkylene, uninterrupted or interrupted by O,Type: GrantFiled: October 25, 2002Date of Patent: April 11, 2006Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Pierre Wolf, Gebhard Hug
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Patent number: 7015360Abstract: This invention relates to asymmetric hydroformylation (hf) processes in which a prochiral or chiral compound is contacted in the presence of an optically active metal-ligand complex catalyst to produce an optically active aldehyde or product derived from an optically active aldehyde. The invention encompasses novel ligands and catalysts for use in such processes.Type: GrantFiled: March 28, 2003Date of Patent: March 21, 2006Assignee: Dow Global Technologies, Inc.Inventors: Gregory Todd Whiteker, Jerzy Klosin, Kelli Jo Gardner
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Patent number: 6977312Abstract: Novel compounds of phosphorus, of arsenic and of antimony can be used as ligands to form complexes of metals of transition group VIII which can be used in catalysts for hydroformylation, hydrocyanation, carbonylation, hydrogenations, oligomerization and polymerization of olefins and for metathesis.Type: GrantFiled: February 9, 2001Date of Patent: December 20, 2005Assignee: BASF AktiengesellschaftInventors: Wolfgang Ahlers, Michael Röper, Peter Hofmann, Daniel C. M. Warth, Rocco Paciello
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Patent number: 6974885Abstract: The method of isolating an anhydrous etidronate disodium particulate includes preparing a liquid-liquid dispersion consisting of an aqueous-organic phase and an etidronate-disodium-salt-containing aqueous phase; adjusting a temperature of the liquid-liquid dispersion to between 0 and 30° C. and intensely agitating so that a coarse-particle fraction precipitates from the liquid-liquid dispersion, then drawing off a fine-particle suspension and allowing a fine-particle fraction to precipitate from it and filtering and drying the coarse particle fraction. In a preferred embodiment the fine-particle fraction is separated from the fine-particle suspension for recycling The resulting anhydrous etidronate disodium particulate has a grain size of from about 0.1 to 1 mm and a bulk density of 0.4 to 0.6 g/cm2 with good properties for pharmaceutical applications.Type: GrantFiled: September 28, 2001Date of Patent: December 13, 2005Assignee: Schering AGInventors: Detlef Grawe, Barbara Schmidt, Harald Raethe
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Patent number: 6972320Abstract: Methods and reagents for the formation of amide bonds between an activated carboxylic acid derivative and an azide useful in the synthesis of peptides, proteins and derivatized or labeled amino acids, peptide or proteins. The method involves the formation of a phosphinothioester which reacts with an azide resulting in amide formation. The invention provides phosphinothiol reagents which convert activated carboxylic acid derivatives to phosphinothioesters which then react with azides to form an amide bond. The methods and reagents of the invention can be used for stepwise synthesis of peptides on solid supports or for the ligation to two or more amino acids, two or more peptide or two or more protein fragments.Type: GrantFiled: May 11, 2001Date of Patent: December 6, 2005Assignee: Wisconsin Alumni Research FoundationInventors: Ronald T. Raines, Laura L. Kiessling, Bradley L. Nilsson
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Patent number: 6969733Abstract: Compounds of the formula I (I), in which Ar is a group or unsubstituted or substituted cyclopentyl, cyclohexyl, naphthyl, biphenylyl or an O-, S- or N-containing 5- or 6-membered heterocyclic ring; R1 and R2 are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 are hydrogen, C1-C20alkyl, OR11 or halogen; R6 is unsubstituted or substituted C1-C24alkyl, C2-C24alkyl, which is interrupted by O, S or NR14 and is unsubstituted or substituted; C2-C24alkenyl, uninterrupted or interrupted by O, S or NR14 and unsubstituted or substituted; unsubstituted or substituted C7-C24arylalkyl; C4-C24cycloalkyl, uninterrupted or interrupted by O, S and/or NR14; or C8-C24arylcycloalkyl; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O or S and unsubstituted or substituted; R12 and R13 are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O atoms and unsubstituted or substituted; or R12 and R13 together are C3-C5alkylene, uninterrupted or interrupted byType: GrantFiled: October 25, 2002Date of Patent: November 29, 2005Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Pierre Wolf, Gebhard Hug
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Patent number: 6900251Abstract: Acrylic ester phosphonic acids of general formula (I), stereoisomers thereof and mixtures of these, wherein n is 1 or 2, on the condition that for n=1 R1 has the meaning and for n=2 R1 has the meaning R2 is a C1 to C12 alkylene radical, C4-C8 cycloalkylene radical or C7 to C15 alkylene phenylene radical; R3 is hydrogen, a C1 to C5 alkyl radical or a C1 to C5 O-alkyl radical; and R4, R5, independently of each other, each stand for a C1 to C5 alkyl radical or a C1 to C5 O-alkyl radical.Type: GrantFiled: June 25, 2003Date of Patent: May 31, 2005Assignee: Ivoclar Vivadent AGInventors: Norbert Moszner, Ulrich Salz, Frank Zeuner, Jörg Zimmermann, Volker Rheinberger, Jorg Angermann, Urs Karl Fischer
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Patent number: 6888031Abstract: A description is given of processes for the preparation of mono- and bisacylphosphines and of mono- and bisacylphosphine oxides and mono- and bisacylphosphine sulfides, which comprises first reacting organic P-monohalogenophosphines or P,P-dihalogenophosphines, or mixtures thereof, with an alkali metal or magnesium in combination with lithium, where appropriate in the presence of a catalyst, and then carrying out the reaction with acid halides and, in the case of the process for the preparation of oxides, carrying out an oxidation step and, in the case of the preparation of sulfides, reacting the phosphines so obtained with sulfur. It is characteristic, inter alia, that the processes are carried out without isolation of the intermediates.Type: GrantFiled: November 20, 1999Date of Patent: May 3, 2005Assignee: Ciba Specialty Chemicals CorporationInventors: David George Leppard, Eugen Eichenberger, René Kaeser, Gebhard Hug, Urs Schwendimann
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Patent number: 6878665Abstract: The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I): in which: R1 and R2 are a (C5-C7)cycloalkyl group, an optionally substituted phenyl group or a 5-membered heteroaryl group; and A is (CH2—CH2) or CF2. The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).Type: GrantFiled: September 16, 2002Date of Patent: April 12, 2005Assignee: SynkemInventors: Sébastien Duprat de Paule, Nicolas Champion, Virginie Vidal, Jean-Pierre Genet, Philippe Dellis
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Patent number: 6849669Abstract: The invention relates to macromolecular hydrophilic photocrosslinkers having polymeric backbones of substituted ethylene groups carrying photoactive groups. The photocrosslinkers are capable of producing, when being exposed to light of determined wavelengths above 305 nm, radicals which are retained on the macromolecular photocrosslinkers and reacting so as to accomplish a crosslinked network structure. The invention further relates to the preparation of photocrosslinkers, their use in different aqueous systems and their utility in production of medical devices including ophthalmic lenses.Type: GrantFiled: March 16, 2000Date of Patent: February 1, 2005Assignee: Pharmacia Groningen BVInventors: Kenneth A. Hodd, Keith Alfred Dillingham, Jacqueline deGroot, Hendrik Haitjema
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Patent number: 6737549Abstract: Compounds of the formula I Ar is a group or unsubstituted or substituted cyclopentyl, cyclohexyl, naphthyl, biphenylyl or an O-, S- or N-containing 5- or 6-membered heterocyclic ring; R1 and R2 are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 are hydrogen, C1-C20alkyl, OR11 or halogen; R6 is unsubstituted or substituted C1-C24alkyl, C2-C24alkyl, which is interrupted by O, S or NR14 and is unsubstituted or substituted; C2-C24alkenyl, uninterrupted or interrupted by O, S or NR14 and unsubstituted or substituted; unsubstituted or substituted C7-C24arylalkyl; C4-C24cycloalkyl, uninterrupted or interrupted by O, S and/or NR14; or C8-C24arylcycloalkyl; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O or S and unsubstituted or substituted; R12 and R13 are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O atoms and unsubstituted or substituted; or R12 and R13 together are C3-C5alkylene, uninterrupted or iType: GrantFiled: May 31, 2001Date of Patent: May 18, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Pierre Wolf, Gebhard Hug
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Patent number: 6683219Abstract: The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.Type: GrantFiled: July 25, 2002Date of Patent: January 27, 2004Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Masato Shimizu, Sachiko Yamada
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Patent number: 6664427Abstract: The invention relates to a process for the making organic aldehyde compounds from an unsaturated compound by hydroformylation and in the presence of a catalyst system comprising a Group VIII metal and a bidentate phosphorus ligand having two trivalent phosphorus atoms bound to salicylanilide groups.Type: GrantFiled: August 29, 2002Date of Patent: December 16, 2003Assignee: E. I. du Pont de Nemours and CompanyInventors: Patrick M. Burke, James Michael Garner, Wilson Tam