Benzene Ring Containing Patents (Class 568/17)
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Publication number: 20080145698Abstract: The invention relates to the improvement of organic electroluminescent devices, especially blue-emitting devices, by using compounds of formula (1) as dopants in the emitting layer.Type: ApplicationFiled: June 22, 2005Publication date: June 19, 2008Applicant: Merck Patent GmbHInventors: Holger Heil, Philipp Stossel, Horst Vestweber
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Publication number: 20080146850Abstract: Method for producing tertiary phosphines by reacting a compound of the general formula (I) in which A is R1 or L2, B is R2 or L3, the R1 and R2 radicals are each independently an organic radical having in each case from 1 to 30 carbon atoms, where the R1 and R2 radicals may also be joined together; and the leaving groups L1 to L3 are each independently halogen, alkyloxy having from 1 to 10 carbon atoms or aryloxy having from 6 to 10 carbon atoms (a) with an alkali metal in an organic aprotic solvent and (b) a compound of the general formula (II) L4-R3 ??(II) in which the R3 radical is an organic radical having in each case from 1 to 30 carbon atoms; and the leaving group L4 is halogen, alkyloxy having from 1 to 10 carbon atoms or aryloxy having from 6 to 10 carbon atoms, in which the resulting reaction mixture is hydrolyzed with an aqueous base which has a pH of ?10 and the organic phase is removed from the aqueous phase.Type: ApplicationFiled: February 9, 2006Publication date: June 19, 2008Applicant: BASF AktiengesellschaftInventors: Kathrin Wissel, Matthias Maase, Oliver Huttenloch, Toni Flajs, Melanie Kuhl
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Publication number: 20080139822Abstract: The invention provides a novel optically active biaryl phosphorus compound that can be produced easily without the step of optical resolution, which is almost indispensable step in a conventional method.Type: ApplicationFiled: December 7, 2007Publication date: June 12, 2008Inventors: Ken Tanaka, Wataru Kuriyama
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Patent number: 7385064Abstract: Disclosed are compounds having the following formula: in which Z11 is selected from a substituted or unsubstituted saturated adamantyl or other polycyclic group and a substituted or unsubstituted branched acyclic group containing at least 5 carbon atoms at least one of which is a tertiary carbon; and in which Z12 is a cyclic imide. Methods of using these compounds as chiral catalysts for carbenoid reactions and for enantioselective C—H aminations are also described.Type: GrantFiled: November 30, 2006Date of Patent: June 10, 2008Assignee: The Research Foundation of State University of New YorkInventors: Huw M. L. Davies, Ravisekhara P. Reddy
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Patent number: 7368585Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.Type: GrantFiled: July 13, 2006Date of Patent: May 6, 2008Assignee: The Trustees Of The University Of PennsylvaniaInventors: Amos B. Smith, III, Thomas J. Beauchamp, Matthew J. LaMarche
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Patent number: 7297821Abstract: A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used for uses of surface treatment, cleaning and coating. Further, after the fluorination reaction, the above compound is recovered and can be reused as a starting material for producing the above fluorine compound, and it is useful for various fluorination processes. (wherein X represents a nitrogen or phosphorus atom; R0, R1, and R2 represent hydrogen, an alkyl group or aryl group which may have a substituent, and they each may be the same or different; and R0, R1, and R2 may be combined with each other to form a ring).Type: GrantFiled: December 9, 2005Date of Patent: November 20, 2007Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Toshio Hidaka, Norio Fushimi, Takafumi Yoshimura, Takeshi Kawai
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Patent number: 7282339Abstract: The present invention provides ligand-detection reagents, ligand analogs and methods for determining the presence of a ligand in a sample. The ligand-detection reagent comprises a ligand-binding antibody and a ligand analog to form an antibody-ligand analog complex wherein the ligand analog is covalently bonded to a reporter molecule. This complex may additionally comprise a labeling protein non-covalently bonded to the antibody to form a ternary complex wherein the labeling protein comprises a monovalent antibody fragment or a non-antibody protein that is covalently bonded to a label moiety. The reporter molecule is either quenched by the ligand-binding antibody or by the label moiety of the labeling protein, depending on the reporter molecule and the ligand-binding antibody, wherein the amount of quenching is directly related to the amount of ligand present in the sample.Type: GrantFiled: September 17, 2004Date of Patent: October 16, 2007Assignee: Invitrogen CorporationInventors: Joseph Beechem, Kyle Richard Gee, David Carl Hagen, Iain D Johnson, Hee-Chol Kang, Christina Pastula
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Patent number: 7268242Abstract: Chelating ligand precursors for the preparation of olefin metathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various metathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene metathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type metathesis catalysts.Type: GrantFiled: January 31, 2006Date of Patent: September 11, 2007Assignee: Materia, Inc.Inventors: Richard L. Pederson, Jason K. Woertink, Christopher M. Haar, David E. Gindelberger, Yann Schrodi
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Patent number: 7256302Abstract: A substituted paracyclophane is described of formula (I) wherein X1 and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl, aryl or heteroaryl, Z1, Z2 and Z3 are substituting groups that optionally contain functional groups, a, b, c, d, e and f are 0 or 1 and a+b+c+d+e+f=1 to 6. Preferably X1 and X2 are —(C2H4)— and a+b+c+d+e+f=1 or 2.Type: GrantFiled: June 8, 2004Date of Patent: August 14, 2007Assignee: Johnson Matthey PLCInventors: Beatriz Dominguez, William Patrick Hems, Antonio Zanotti-Gerosa
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Patent number: 7238841Abstract: Novel phosphine and phosphine oxide ligands are prepared using polymeric supports. These compounds can be easily cleaved from the support, and along with the corresponding supported compounds, used as ligands in the preparation of novel, metal-complexed catalysts.Type: GrantFiled: May 30, 2003Date of Patent: July 3, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Paul J. Fagan, George Yanwu Li
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Patent number: 7230136Abstract: The invention relates to a process for synthesizing tertiary phosphines by reacting halophosphines with organomagnesium compounds in the presence of copper compounds and optionally of salts.Type: GrantFiled: April 17, 2003Date of Patent: June 12, 2007Assignee: LANXESS Deutschland GmbHInventors: Florian Rampf, Hans-Christian Militzer
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Patent number: 7208633Abstract: A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.Type: GrantFiled: December 5, 2002Date of Patent: April 24, 2007Assignee: Takeda Pharmaceutical Company LimitedInventors: Mitsutaka Goto, Mitsuhisa Yamano
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Patent number: 7201957Abstract: There is disclosed a novel mixture of polyhydroxy phenolic curing agents, such as novolac resins blended with a mixture of mono, bis and tris hydroxyaryl phosphine oxides for co-curing epoxy resins and imparting flame resistance thereto. A preferred composition includes a mixture of monohydroxyaryl, bishydroxyaryl and trishydroxyaryl phosphine oxide and a benzoguanamine/phenol/formaldehyde terpolymer which is used along with an epoxy resin to produce flame-resistant printed wiring boards without the use of halogens.Type: GrantFiled: June 14, 2004Date of Patent: April 10, 2007Assignee: Great Lakes CorporationInventors: Larry D. Timberlake, Mark V. Hanson, E. Bradley Edwards
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Patent number: 7202311Abstract: There is disclosed a novel mixture of polyhydroxy phenolic curing agents, such as novolac resins blended with a mixture of mono, bis and tris hydroxyaryl phosphine oxides for co-curing epoxy resins and imparting flame resistance thereto. A preferred composition includes a mixture of monohydroxyaryl, bishydroxyaryl and trishydroxyaryl phosphine oxide and a benzoguanamine/phenol/formaldehyde terpolymer which is used along with an epoxy resin to produce flame-resistant printed wiring boards without the use of halogens.Type: GrantFiled: June 14, 2004Date of Patent: April 10, 2007Assignee: Great Lakes CorporationInventors: Larry D. Timberlake, Mark V. Hanson, E. Bradley Edwards
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Patent number: 7122703Abstract: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: March 6, 2003Date of Patent: October 17, 2006Assignee: The Regents of the University of CaliforniaInventors: Eliana Saxon, Carolyn Bertozzi
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Patent number: 7109286Abstract: A phosphorus-containing hydroquinone derivative represented by a general formula (1): (where R1 and R2 represent linear or branched alkyl groups that are identical or may be different, and/or R1 and R2 may form a circular group; X represents an oxygen atom or sulfur atom; Y and Z represent hydrogen atom, hydroxy group, linear or branched alkyl group, aralkyl group, alkoxy group, allyl group, aryl group or cyano group, and/or Y and Z may form a circular group). The present invention provides phosphorus-containing hydroquinone derivatives that are useful for intermediate materials for reactive type flame-retardant agents or phosphorus-containing epoxy resins.Type: GrantFiled: June 20, 2001Date of Patent: September 19, 2006Assignee: Nippon Chemical Industrial Co., Ltd.Inventors: Ken Tamura, Eiichi Tatsuya, Yoshirou Kaneda, Natsuhiro Sano
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Patent number: 7091292Abstract: Ligands, compositions, metal-ligand complexes and arrays with substituted bridged bis-biaromatic ligands, and methods of making and using the same, are disclosed that are useful in the catalysis of transformations such as the polymerization of monomers into polymers. The catalysts have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.Type: GrantFiled: April 28, 2005Date of Patent: August 15, 2006Assignee: Symyx Technologies, Inc.Inventors: Thomas Boussie, Oliver Bruemmer, Gary M. Diamond, Anne M. LaPointe, Margarete K. Leclerc, Cynthia Micklatcher, Pu Sun, Xiaohong Bei
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Patent number: 7081533Abstract: The present invention concerns novel unsymmetrical chiral diphosphines of a mixed aliphatic-aromatic type and processes for synthesizing them, complexes of these compounds and their use as catalysts.Type: GrantFiled: August 17, 2001Date of Patent: July 25, 2006Assignee: Degussa AGInventors: Boris E Bosch, Axel Monsees, Uwe Dingerdissen, Paul Knochel, Eike Hupe
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Patent number: 7078568Abstract: Phosphine compounds represented by the following formula (1): wherein R1, R2, R3, R4, R5, R6 and R7 represent substituents, and asymmetric synthesis catalysts containing transition metal phosphine complexes with the compounds contained as ligands therein. The novel phosphine compounds according to the present invention are useful especially as ligands in transition metal complexes. The transition metal phosphine complexes are useful as catalysts for asymmetric synthetic reactions. The novel phosphine compounds useful as ligands can be prepared by a relatively economical preparation process. Further, use of these catalysts can afford hydrogenated products with high optically purity and is also extremely useful from the industrial standpoint.Type: GrantFiled: August 18, 2005Date of Patent: July 18, 2006Assignee: Takasago International CorporationInventors: Hideo Shimizu, Takao Saito, Izuru Nagasaki
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Patent number: 7074505Abstract: The present invention is generally directed to luminescent lanthanide compounds with phosphine oxide, phosphine oxide-sulfide, pyridine N-oxide, and phosphine oxide-pyridine N-oxide ligands. It also relates to electronic devices in which the active layer includes a lanthanide complex.Type: GrantFiled: December 14, 2004Date of Patent: July 11, 2006Assignee: E. I. du Pont de Nemours and CompanyInventors: Vladimir Grushin, Norman Herron, Viacheslav A. Petrov, Nora Sabina Radu, Ying Wang
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Patent number: 7074737Abstract: A process for the alkylation of triphenylphosphate by reaction of triphenylphosphate with an olefin in the presence of an effective amount of a solid acid catalyst selected from the group consisting of at least one zeolite, heteropolyacid or salt thereof, metal triflate, non-aryl group-containing metal sulfonic acid, metal halide Lewis acid, or compatible mixture of any such catalyst.Type: GrantFiled: December 23, 2003Date of Patent: July 11, 2006Assignee: Supresta U.S. LLCInventors: Alan J. Abramson, Anantha Desikan, Shuguang Zhang, Zongchao Zhang, James Liang
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Patent number: 7074504Abstract: The present invention is generally directed to luminescent lanthanide compounds with phosphine oxide, phosphine oxide-sulfide, pyridine N-oxide, and phosphine oxide-pyridine N-oxide ligands. It also relates to electronic devices in which the active layer includes a lanthanide complex.Type: GrantFiled: December 14, 2004Date of Patent: July 11, 2006Assignee: E. I. du Pont de Nemours and CompanyInventors: Vladimir Grushin, Norman Herron, Viacheslav A. Petrov, Nora Sabina Radu, Ying Wang
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Patent number: 7034093Abstract: Late transition metal complexes of certain neutral iminophosphine ligands are useful as components of polymerization catalysts for olefins. Useful metals in the complexes include Ni, Pd, Fe and Co. Oligomers and/or polymers of olefins such as ethylene can be made.Type: GrantFiled: March 5, 2003Date of Patent: April 25, 2006Assignees: E. I. du Pont de Nemours and Company, University of North CarolinaInventors: Maurice S. Brookhart, Olafs Daugulis
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Patent number: 7026017Abstract: Compounds of the formula I in which Ar is a group or unsubstituted or substituted cyclopentyl, cyclohexyl, naphthyl, biphenylyl or an O-, S- or N-containing 5- or 6-membered heterocyclic ring; R1 and R2 are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 are hydrogen, C1-C20alkyl, OR11 or halogen; R6 is unsubstituted or substituted C1-C24alkyl, C2-C24alkyl, which is interrupted by O, S or NR14 and is unsubstituted or substituted; C2-C24alkenyl, uninterrupted or interrupted by O, S or NR14 and unsubstituted or substituted; unsubstituted or substituted C7-C24arylalkyl; C4-C24cycloalkyl, uninterrupted or interrupted by O, S and/or NR14; or C8-C24arylcycloalkyl; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O or S and unsubstituted or substituted; R12 and R13 are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O atoms and unsubstituted or substituted; or R12 and R13 together are C3-C5alkylene, uninterrupted or interrupted by O,Type: GrantFiled: October 25, 2002Date of Patent: April 11, 2006Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Pierre Wolf, Gebhard Hug
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Patent number: 7026498Abstract: One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.Type: GrantFiled: October 23, 2001Date of Patent: April 11, 2006Assignee: Massachusetts Institute of TechnologyInventors: Stephen L. Buchwald, David W. Old, John P. Wolfe, Michael Palucki, Ken Kamikawa
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Patent number: 7022866Abstract: Phosphonites I of the formula 1 or 2 where R1, R2 are each, independently of one another, hydrogen, an alkyl or alkylene group having from 1 to 8 carbon atoms or an alkoxy group having from 1 to 8 carbon atoms, with the proviso that R1 and R2 are not simultaneously H, R3 is H or methyl, R4 is t-butyl, R5, R6, R7, R8, R9 are each, independently of one another, H or an alkyl or alkylene group having from 1 to 8 carbon atoms.Type: GrantFiled: October 1, 2002Date of Patent: April 4, 2006Assignee: BASF AktiengesellschaftInventors: Michael Bartsch, Robert Baumann, Dagmar Pascale Kunsmann-Keitel, Gerd Haderlein, Tim Jungkamp, Marco Altmayer, Wolfgang Siegel, Ferenc Molnar
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Patent number: 7019173Abstract: A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used for uses of surface treatment, cleaning and coating. Further, after the fluorination reaction, the above compound is recovered and can be reused as a starting material for producing the above fluorine compound, and it is useful for various fluorination processes. (wherein X represents a nitrogen or phosphorus atom; R0, R1, and R2 represent hydrogen, an alkyl group or aryl group which may have a substituent, and they each may be the same or different; and R0, R1, and R2 may be combined with each other to form a ring).Type: GrantFiled: August 22, 2002Date of Patent: March 28, 2006Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Toshio Hidaka, Norio Fushimi, Takafumi Yoshimura, Takeshi Kawai
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Patent number: 7001922Abstract: The invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula:Type: GrantFiled: November 14, 2003Date of Patent: February 21, 2006Assignee: Celmed Oncology (USA), Inc.Inventors: Carlo Ballatore, Maria V. Sergeeva, Venkata Ramana Doppalapudi
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Patent number: 6987202Abstract: Phosphine compounds represented by the following formula (1): wherein R1, R2, R3, R4, R5, R6 and R7 represent substituents, and asymmetric synthesis catalysts containing transition metal phosphine complexes with the compounds contained as ligands therein. The novel phosphine compounds according to the present invention are useful especially as ligands in transition metal complexes. The transition metal phosphine complexes are useful as catalysts for asymmetric synthetic reactions. The novel phosphine compounds useful as ligands can be prepared by a relatively economical preparation process. Further, use of these catalysts can afford hydrogenated products with high optically purity and is also extremely useful from the industrial standpoint.Type: GrantFiled: November 6, 2003Date of Patent: January 17, 2006Assignee: Takasago International CorporationInventors: Hideo Shimizu, Takao Saito, Izuru Nagasaki
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Patent number: 6984744Abstract: The invention is concerned with new phosphine ligands of formula I wherein R1 and R2 are independently of each other unsubstituted alkyl, aryl, cycloalkyl or heteroaryl, or alkyl, aryl, cycloalkyl or heteroaryl each of which independently is substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3?, —CO—NR8R8?, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl; R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4? and R4 are independently of each other hydrogen, alkyl or optionally substituted aryl; or R4? and R4 together with the C-atom they are attached, form a 3-8-membered carbocyclic ring; dotted line is optionally a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl, R7 is alkyl or aryl; and R8 and R8? are independently of each other hydrogen, alkyl or aryl; the substituents attached by the bold bonds are in cis relation to each other; metal complexes with such ligands in asymmetric reactions.Type: GrantFiled: November 21, 2003Date of Patent: January 10, 2006Assignee: Hoffman-La Roche Inc.Inventors: Piotr Osinski, Kazimierz Michal Pietrusiewicz, Rudolf Schmid
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Patent number: 6977312Abstract: Novel compounds of phosphorus, of arsenic and of antimony can be used as ligands to form complexes of metals of transition group VIII which can be used in catalysts for hydroformylation, hydrocyanation, carbonylation, hydrogenations, oligomerization and polymerization of olefins and for metathesis.Type: GrantFiled: February 9, 2001Date of Patent: December 20, 2005Assignee: BASF AktiengesellschaftInventors: Wolfgang Ahlers, Michael Röper, Peter Hofmann, Daniel C. M. Warth, Rocco Paciello
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Patent number: 6969756Abstract: Novel phosphorus element-containing vinyl ester resin compositions and process for preparing epoxy vinyl ester resin compositions include non-halogenated, ignition resistant epoxy vinyl ester resin formulations. The ignition resistant epoxy vinyl ester resin formulations are advantageously used for making laminates for printed wiring boards and composite materials.Type: GrantFiled: March 9, 2004Date of Patent: November 29, 2005Assignee: Dow Global Technologies Inc.Inventors: David J. Brennan, John P. Everett, Bassam S. Nader
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Patent number: 6924389Abstract: Diphosphine of formula I R1R2P—H2C—Ar—CH2PR1R2??(I) are prepared by a process that comprises a) reacting a dimethyl compound of formula II H3C—Ar—CH3??(II) with a base and an N-substituted aminophosphorous halide to form bis(aminophosphinomethyl) compound of the formula III R3R4P—H2C—Ar—CH2—PR3R4??(III) b) reacting the compound of formula III with HCl to form bis(dichlorophosphinomethyl) compound of formula IV Cl2P—H2C—Ar—CH2—PCl2??(IV) and c) reacting the compound of formula IV with an organometallic reagent to give the product compound of formula I, wherein groups R1 and R2 are each, independently of one another, a substituted or unsubstituted aromatic, heteroaromatic or aliphatic hydrocarbon group and may have a covalent bond connecting them and Ar is a substituted or unsubstituted aromatic or heteroaromatic hydrocarbon group an R3 and R4 are each, independently of one another, an N-substituted alkylamino or arylamino group.Type: GrantFiled: March 19, 2002Date of Patent: August 2, 2005Assignee: Oxeno Olefinchemie GmbHInventors: Ralf Jackstell, Holger Klein, Matthias Beller, Klaus-Diether Wiese, Cornelia Borgmann
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Patent number: 6914161Abstract: Multidentate phosphate compounds of formula (1) are prepared by reacting a 9-phosphabicyclononane, in the presence of an acid catalyst, with a 9-phospha-bicyclononane alkenylmonophosphine of formula (2), some of which, e.g., P-{2-(2-butenyl)}-9-phospha-bicyclononane, are novel compounds. The multidentate phosphine compounds of formula (1) and those of formula (3), are useful as ligands for transition metal catalysts in various types of reactions, such as, hydrogenation reactions.Type: GrantFiled: May 1, 2002Date of Patent: July 5, 2005Assignee: DSM IP Assets B.V.Inventors: Felix Hugo Beijer, Edwin Gerard Ljpeij
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Patent number: 6887950Abstract: A mixture of hydroxyarylphosphine oxides comprising (a) a mono(hydroxyaryl)phosphine oxide, (b) a bis(hydroxyaryl)phosphine oxide, (c) a tris((hydroxyaryl)phosphine oxide, and, optionally (d) a tri- aryl, alkyl, or aralkyl-substituted phosphine oxide combined with a phenolic co-crosslinking composition is useful as a polyhtdroxy mixture for co-crosslinking an epoxy resin which also imparts flame resistance.Type: GrantFiled: December 12, 2002Date of Patent: May 3, 2005Assignee: PABU Services, Inc.Inventors: Larry D. Timberlake, Mark V. Hanson, E. Bradley Edwards
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Patent number: 6878665Abstract: The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I): in which: R1 and R2 are a (C5-C7)cycloalkyl group, an optionally substituted phenyl group or a 5-membered heteroaryl group; and A is (CH2—CH2) or CF2. The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).Type: GrantFiled: September 16, 2002Date of Patent: April 12, 2005Assignee: SynkemInventors: Sébastien Duprat de Paule, Nicolas Champion, Virginie Vidal, Jean-Pierre Genet, Philippe Dellis
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Patent number: 6855849Abstract: Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.Type: GrantFiled: September 18, 2002Date of Patent: February 15, 2005Assignee: Warner-Lambert CompanyInventors: Garrett Stewart Hoge, II, Om Prakash Goel
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Patent number: 6841304Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, O, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FX1O)N?(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.Type: GrantFiled: November 9, 2001Date of Patent: January 11, 2005Assignees: ACEP, Inc., Centre National de la Recherche Scientifique, Universite de MontrealInventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
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Patent number: 6806378Abstract: The present invention provides a catalyst system and a process for the preparation of a nonracemic chiral alcohol by hydrogenation of a ketone using the catalyst system, wherein the catalyst system comprises ruthenium, a nonracemic chiral diphosphine ligand, an amino-thioether ligand, and a base.Type: GrantFiled: May 21, 2002Date of Patent: October 19, 2004Assignee: DSM N.V.Inventors: Charles E. Tucker, Qiongzhong Jiang
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Patent number: 6777559Abstract: A process for the preparation heterocyclic indene analogs, especially with the preparation of 4-hydroxycarbazole or N-protected 4-hydroxycarbazole, involves cyclocarbonylation followed by saponification. This process avoids high temperatures and high catalyst loadings.Type: GrantFiled: January 22, 2002Date of Patent: August 17, 2004Assignee: Hoffmann-La Roche Inc.Inventors: Michelangelo Scalone, Thomas Albert Zeibig
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Publication number: 20040147785Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P-L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P-L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.Type: ApplicationFiled: January 15, 2004Publication date: July 29, 2004Inventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Wolf Eilenberg, Ursula Eilenberg-Robben
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Patent number: 6762329Abstract: One aspect of the present invention relates to novel reaction conditions that allow the efficient synthesis of diaryl ethers from arenes bearing a leaving group and arenols under relatively mild conditions. Another aspect of the present invention relates to the dramatic effects of acidic activators on Ullmann-type couplings involving electron-poor and/or relatively insoluble substrates.Type: GrantFiled: April 25, 2002Date of Patent: July 13, 2004Assignee: Massachusetts Institute of TechnologyInventors: Jean-Francois Marcoux, Sven Doye, Stephen Buchwald
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Patent number: 6740732Abstract: Novel phosphorus element-containing epoxy resin compositions and novel phosphorus-element containing epoxy resin compositions based on an isomeric mixture of tris(2-hydroxyphenyl)-phosphine oxide compounds including non-halogenated, ignition resistant epoxy resin formulations. The ignition resistant epoxy resin formulations are advantageously used for making laminates for printed wiring boards and composite materials.Type: GrantFiled: April 11, 2002Date of Patent: May 25, 2004Assignee: Dow Global Technologies Inc.Inventors: David J. Brennan, John P. Everett, Bassam S. Nader
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Patent number: 6733698Abstract: A mixture of hydroxyarylphosphine oxides comprising (a) a mono(hydroxyaryl)phosphine oxide, (b) a bis(hydroxyaryl)phosphine oxide, (c) a tris(hydroxyaryl)phosphine oxide, and, optionally (d) a tri- aryl, alkyl or aralkyl-substituted phosphine oxide is useful in the preparation of polyglycidyl ethers derived therefrom, or is employed as flame retardants in epoxy resin compositions which can be processed into resin-impregnated composites.Type: GrantFiled: February 14, 2002Date of Patent: May 11, 2004Assignee: PABU Services, Inc.Inventors: Mark V. Hanson, Larry D. Timberlake
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Patent number: 6730629Abstract: A phosphine compound having excellent properties (chemical selectivity, enantioselectivity, catalytic activity) as a catalyst for asymmetric syntheses, especially asymmetric hydrogenations. A phosphine-phospholane compound represented by the following formula (1): a phosphine-primary phosphine intermediate; a transition metal complex including the phosphine-phospholane compound of formula (1) and a transition metal, and a catalyst including the transition metal complex.Type: GrantFiled: December 10, 2002Date of Patent: May 4, 2004Assignee: Takasago International CorporationInventors: Kazuhiko Matsumura, Takao Saito
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Patent number: 6730813Abstract: The invention relates to a method for producing N-(phosphonomethyl)glycine involving the following steps: (a) oxidizing N-(phosphonomethyl)iminodiacetic acid (PMIDA) with peroxides or oxygen in an aqueous medium and in the presence of a heterogeneous catalyst at a temperature ranging from 50 to 150° C.; (b) subsequently separating the solid catalyst out of the aqueous reaction suspension of step (a); (c) concentrating the clear reaction solution from step (b), especially by evaporation, and; (d) separating the N-(phosphonomethyl)glycine out of the concentrated reaction solution from step (c), especially by filtration. According to the invention, the aqueous reaction solution from step (d) (mother liquor) is returned with small amounts of N-(phosphonomethyl)glycine and byproducts to step (b) (catalyst separation) and/or to step (c) (concentration). This results in distinctly increasing the yield with a constant product purity and in noticeably reducing the amount of mother liquor.Type: GrantFiled: August 16, 2002Date of Patent: May 4, 2004Assignee: Monsanto Technology LLCInventors: Martin Hitzler, Franz Thalhammer, Benedikt Hammer
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Publication number: 20040073065Abstract: A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used for uses of surface treatment, cleaning and coating. Further, after the fluorination reaction, the above compound is recovered and can be reused as a starting material for producing the above fluorine compound, and it is useful for various fluorination processes.Type: ApplicationFiled: June 4, 2003Publication date: April 15, 2004Inventors: Toshio Hidaka, Norio Fushimi, Takafumi Yoshimura, Takeshi Kawai
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Patent number: 6689915Abstract: Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.Type: GrantFiled: February 27, 2002Date of Patent: February 10, 2004Assignee: Warner-Lambert Company LLCInventors: Garrett Stewart Hoge, II, Om Prakash Goel
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Patent number: 6677462Abstract: This invention relates to preparation of enantio-enriched compounds, and more particularly to enantio-enriched kavalactone compounds and derivatives thereof. The methods provide compounds that are useful as reagents, or building blocks, in the construction of other enantio-enriched compounds.Type: GrantFiled: August 6, 2001Date of Patent: January 13, 2004Assignee: Kava Pharmaceuticals, Inc.Inventors: Shoujun Chen, Lijun Sun, Joel McCleary
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Patent number: RE39532Abstract: The novel metallocenes of the formula I in which, preferably, M1 is Zr or Hf, R1 and R2 are alkyl or halogen, R3 and R4 are hydrogen, R5 and R6 are alkyl or haloalkyl, —(CR8R9)m—R7—(CR8R9)n— is a single- or multi-membered chain in which R7 may also be a (substituted) hetero atom, m+n is zero or 1, and R10 is hydrogen, form, together with aluminoxanes as cocatalysts, a very effective catalyst system for the preparation of polyolefins of high stereospecificity and high melting point.Type: GrantFiled: July 17, 1997Date of Patent: March 27, 2007Assignee: Basell Polyolefine GmbHInventors: Andreas Winter, Martin Antberg, Walter Spaleck, Jürgen Rohrmann, Volker Dolle