Reactant Contains -coo- Group Patents (Class 568/314)
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Publication number: 20150011749Abstract: Metal-accumulating plants for preparing compositions including a metal catalyst derived from the plants. The composition is substantially devoid of organic matter. Also, carrying out chemical reactions with the compositions prepared from metal-accumulating plants.Type: ApplicationFiled: March 5, 2013Publication date: January 8, 2015Applicants: UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Claude Grison, Vincent Escande
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Publication number: 20140107372Abstract: In order to provide a novel method for producing a cyclopentanone compound, the present invention is a method for producing a cyclopentanone compound represented by the formula (I). The method includes the steps of: substituting the group represented by Y by a hydrogen atom by allowing a compound represented by the formula (III) or an intermediate compound obtained from the compound represented by the formula (III) to react with a catalyst or a halogenating agent; and substituting, by hydrogen atoms, (i) the group or the atom represented by Z1 and (ii) the group or the atom represented by Z2, by reducing the compound represented by the formula (III) or the intermediate compound obtained from the compound represented by the formula (III).Type: ApplicationFiled: June 4, 2012Publication date: April 17, 2014Applicant: KUREHA CORPORATIONInventor: Hisashi Kanno
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Publication number: 20140017183Abstract: The invention relates to a process for the manufacture of substituted dibenzoylmethane derivatives. This economical process provides products in high purity and yields and results in shorter reaction times.Type: ApplicationFiled: December 19, 2011Publication date: January 16, 2014Applicant: DSM IP ASSETS B.V.Inventor: Christof Wehrli
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Patent number: 8618346Abstract: The subject invention provides a potentially economically viable process for the destruction of small to large quantities of sulfur and nitrogen mustards and lewisite, their homologous/analogues, and similar chemical warfare agents at ambient conditions without producing any toxic by-products. The process uses the superoxide ion that is either electrochemically generated by the reduction of oxygen in ionic liquids or chemically by dissolving Group 1 (alkali metals) or Group 2 (alkaline earth metals) superoxides, e.g. potassium superoxide, in ionic liquids.Type: GrantFiled: March 26, 2008Date of Patent: December 31, 2013Assignee: King Saud UniversityInventors: Inas Muen Al Nashef, Saeed M. Al Zahrani
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Publication number: 20130338398Abstract: There is provided a process for the preparation of a compound of formula (I), wherein R1, R2, R3, R4, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.Type: ApplicationFiled: July 18, 2013Publication date: December 19, 2013Inventor: Lars EKLUND
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Patent number: 8563766Abstract: A compound of Formula (4), wherein each X is independently fluorine or chlorine; n is 1 or 2; R1 is C3-C8 alkyl, phenyl or benzyl; and R2 is C1-C6 alkyl; and its production and use.Type: GrantFiled: July 22, 2010Date of Patent: October 22, 2013Assignee: DSM Pharma ChemicalsInventor: Peter Hans Ermann
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Patent number: 8487138Abstract: In a process for oxidizing a hydrocarbon to a corresponding hydroperoxide, alcohol, ketone, carboxylic acid or dicarboxylic acid, the hydrocarbon is contacted with an oxygen-containing gas in the presence of a catalyst comprising a cyclic imide of the general formula (I): wherein each of R1 and R2 is independently selected from hydrocarbyl and substituted hydrocarbyl radicals having 1 to 20 carbon atoms, or from the groups SO3H, NH2, OH and NO2, or from the atoms H, F, Cl, Br and I provided that R1 and R2 can be linked to one another via a covalent bond; each of Q1 and Q2 is independently selected from C, CH, N and CR3; each of X and Z is independently selected from C, S, CH2, N, P and an element of Group 4 of the Periodic Table; Y is O or OH; k is 0, 1, or 2; 1 is 0, 1, or 2; m is 1 to 3, and R3 can be any of the entities listed for R1.Type: GrantFiled: July 11, 2008Date of Patent: July 16, 2013Assignee: ExxonMobil Chemical Patents Inc.Inventors: Jihad M. Dakka, James C. Vartuli, Stephen Zushma
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Patent number: 8314045Abstract: A porous solid acid catalyst having high concentration of acidic sites and a large surface area includes a porous silica support and a sulfonated carbon layer disposed within the pores of the silica support. The catalyst, in certain embodiments, has a concentration of —SO3H groups of at least about 0.5 mmol/g and a predominant pore size of at least about 300 ?. The catalyst is used to catalyze a variety of acid-catalyzed reactions, including but not limited to alkylation, acylation, etherification, olefin hydration and alcohol dehydration, dimerization of olefin and bicyclic compounds, esterification and transesterification. For example, the catalyst can be used to catalyze esterification of free fatty acids (FFAs) and, in certain embodiments, to catalyze transesterification of triglycerides in fats and oils.Type: GrantFiled: October 27, 2010Date of Patent: November 20, 2012Assignee: Entreprises Sinoncelli S.A.R.L.Inventors: Jacques Sinoncelli, Sergey V. Gurevich
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Patent number: 8283499Abstract: The present invention relates the use of 2,3-dihalonaphthoquinone compounds of Formula I wherein R1 and R2 are leaving groups like halogens selected from the group comprising Cl, Br, I and F and the R1 and R2 may be the same halogen or may contain different halogen groups, or sulphonyl groups, for making napthoquinone compounds of Formula IA wherein X is any aryl, heteroaryl, alkyl, cyclohexyl, substituted cylohexyl groups and the like.Type: GrantFiled: March 6, 2009Date of Patent: October 9, 2012Assignee: Alkem Laboratories LimitedInventors: Sanjay Sukumar Saralya, Shashikumar Hiriyalu Somashekar, Shashiprabha, Shridhara Kanakamajalu, Koottungalmadhom Ramaswamy Ranganathan, Veerasamy Ananthalakshmi, Govindarajalu Jeyaraman, Kothapalli Sundarraja Rao, Kuppuswamy Nagarajan
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Publication number: 20120245360Abstract: The present invention relates to a process for the production of trifluoromethylated unsubstituted or substituted aryl or heteroaryl compounds which comprises reacting an unsubstituted or substituted aryl or heteroaryl halide with a trifluoroacetate of formula (I) or (II), wherein R1 is hydrogen or a C1-C5 alkyl group and M an alkali metal or an ammonium ion, in the presence of and an anorganic halogenide salt or a trifluoroacetacid salt as activator compound and a catalytic combination of a copper salt with a monodentate, bidentate or tridentate aromatic or aliphatic amine or pyridine ligand.Type: ApplicationFiled: October 26, 2011Publication date: September 27, 2012Applicant: SALTIGO GMBHInventors: Alain Cotté, Matthias Gotta, Matthias Beller, Thomas Schareina, Alexander Zapf, Xiao-feng Wu
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Publication number: 20120238450Abstract: The present invention relates to novel c2-phenyl-substituted cyclic ketoenols, to a plurality of processes for their preparation and to their use as pesticides as herbicides.Type: ApplicationFiled: April 25, 2012Publication date: September 20, 2012Applicant: Bayer AktiengesellschaftInventors: Michael Ruther, Hermann Hagemann, Udo Schneider, Markus Dollinger, Peter Dahmen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Thomas Bretschneider, Christoph Erdelen, Mark Wilhelm Drewes, Dieter Feucht, Folker Lieb
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Publication number: 20120165567Abstract: The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz.Type: ApplicationFiled: March 26, 2010Publication date: June 28, 2012Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Abhishek Sharma, Arun Kumar Sinha, Rakesh Kumar, Naina Sharma
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Publication number: 20120130084Abstract: The application relates to processes for preparing fipamezole and its pharmaceutically acceptable salts, and intermediates thereof. It also provides intermediate compounds of Formula III and Formula IV, and processes for their preparation.Type: ApplicationFiled: January 31, 2012Publication date: May 24, 2012Applicants: DR. REDDY'S LABORATORIES, INC., DR. REDDY'S LABORATORIES LTD.Inventors: Ranjan Bhowmik Dipal, Lingam Yedugani, Raghavndra Rao Kamaraju, Subba Rao Jammula, Swapna Manikonda, Vilas H. Dahanukar
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Publication number: 20120130129Abstract: The disclosed process can efficiently synthesize functionalized benzosuberenes. The process provides an improved method of production of benzosuberene and compounds containing a benzosuberene moiety, which is characterized by a ring closing methodology comprising reaction of a 5-phenylpentanoic acid with Eaton's reagent to form the benzosuberone. The process, optionally, further includes steps for adding a functional group at the ketone position.Type: ApplicationFiled: November 16, 2011Publication date: May 24, 2012Applicant: BAYLOR UNIVERSITYInventors: Kevin G. Pinney, Madhavi Sriram, Clinton George, Rajendra P. Tanpure
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Publication number: 20120046356Abstract: There is provided a process for the preparation of a compound of formula (III), wherein X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone. There is also provided a process for the preparation of a compound of formula (I).Type: ApplicationFiled: October 2, 2009Publication date: February 23, 2012Applicant: CAMBREX KARLSKOGA ABInventor: Lars Eklund
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Publication number: 20110178314Abstract: The present invention relates to a process for the preparation of a compound of formula wherein R1 is selected from C1-6-alkyl, C3-6-cycloalkyl and aralkyl, and wherein R2 at each occurrence independently is halogen or C1-6-alkyl, and m is an integer from 0 to 4, Q is selected from halogen, —NO2 and —NR3R4, wherein R3 and R4 are independently selected from hydrogen, C1-6-alkyl, C3-6-cycloalkyl, aryl, aralkyl, mesyl and tosyl, or wherein R3 and R4 together form a C4-6-alkylene group, Y at each occurrence is hydrogen or a hydroxy protection group W that can be hydrolytically cleaved under acidic conditions, and n is an integer from 1 to 3, and n is an integer from 1 to 3, with the proviso that n and m together are not greater than 5.Type: ApplicationFiled: October 10, 2008Publication date: July 21, 2011Inventors: Alain Wellig, Jean-Paul Roduit, Danmei Dai, Rongmin Chen
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Publication number: 20110004024Abstract: The present invention relates the use of 2,3-dihalonaphthoquinone compounds of Formula I wherein R1 and R2 are leaving groups like halogens selected from the group comprising Cl, Br, I and F and the R1 and R2 may be the same halogen or may contain different halogen groups, or sulphonyl groups, for making napthoquinone compounds of Formula IA wherein X is any aryl, heteroaryl, alkyl, cyclohexyl, substituted cylohexyl groups and the like.Type: ApplicationFiled: March 6, 2009Publication date: January 6, 2011Applicant: ALKEM LABORATORIES LIMITEDInventors: Sanjay Sukumar Saralya, Shashikumar Hiriyalu Somashekar, Shashiprabha, Shridhara Kanakamajalu, Koottungalmadhom Ramaswamy Ranganathan, Veerasamy Ananthalakshmi, Govindarajalu Jeyaraman, Kothapalli Sundarraja Rao, Kuppuswamy Nagarajan
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Patent number: 7847127Abstract: Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as “Form IPCA-ATO,” and the preparation thereof.Type: GrantFiled: October 21, 2009Date of Patent: December 7, 2010Assignee: IPCA Laboratories LimitedInventors: Ashok Kumar, Suneel Yeshwant Dike, Pramil Kumar Mathur, Nellithanath Thankachen Byju, Brajesh Sharma, Swapnil Shreekant Kore, Vitthal Suryabhan Buchude, Dharmendra Singh
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Publication number: 20100292319Abstract: There is provided a process for the preparation of a compound of formula (I), wherein R1, R2, R3, R4, X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone. Intermediate steps of the process comprise formulae according to (II) and (III).Type: ApplicationFiled: October 2, 2008Publication date: November 18, 2010Applicant: CAMBREX KARLSKOGA ABInventor: Lars Eklund
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Publication number: 20100081847Abstract: Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as “Form IPCA-ATO,” and the preparation thereof.Type: ApplicationFiled: October 21, 2009Publication date: April 1, 2010Inventors: Ashok Kumar, Suneel Yeshwant Dike, Pramilkumar Mathur, Nellithanath Thankachen Byju, Brajesh Sharma, Swapnil Shreekant Kore, Vitthal Suryabhan Buchude, Dharmendra Singh
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Publication number: 20090275666Abstract: The invention relates to a condensation product obtainable by reaction of a1) at least one aromatic or heteroaromatic, where the aromatic or heteroaromatic is substituted by at least one hydroxyl group (—OH) and at least one carboxyl group (—COOH), and where the hydroxyl and/or carboxyl group can be present in salt form, a2) at least one carbonyl compound, a3) optionally at least one sulfonating agent a4) optionally at least one urea derivative, and a5) optionally at least one further aromatic or heteroaromatic, or a physiologically tolerable salt thereof, with the precondition that the component a1) is not salicylic acid or sulfosalicylic acid if the component a4) is melamine.Type: ApplicationFiled: February 28, 2007Publication date: November 5, 2009Applicant: BASF SEInventors: Stephan Hueffer, Sebastien Garnier, Oliver Reese, Guenter Scherr, Joachim Roser, Ulrich Mrowietz
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Patent number: 7595425Abstract: A preparation process of aromatic ketones by a Friedel-Crafts acylation reaction in an ionic liquid of formula (I), in the absence of any other catalyst and/or solvent. In formula (I), [Q]+ is selected from substituted-imidazolium cations, substituted-pyridinium cations, ammonium cations, and phosponium cations. It allows to carry out Friedel-Crafts acylations with good yields and high selectivity in para position of the Friedel-Crafts aromatic substrate without using chlorine-containing solvents and conventional Friedel-Crafts catalysts. It is industrially useful because provides a “Green Chemistry” technology for carrying out Friedel-Crafts acylations of general aplicability.Type: GrantFiled: January 20, 2005Date of Patent: September 29, 2009Assignee: Institut Universitari de Ciencia I TecnologiaInventors: Carles Estévez Company, Lidia Gallä Prats, Josep Castells Boliart
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Patent number: 7468462Abstract: The present invention is directed to novel compounds according to formulae wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.Type: GrantFiled: November 1, 2006Date of Patent: December 23, 2008Assignee: Auspex PharmaceuticalsInventor: Sepehr Sarshar
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Patent number: 7235698Abstract: Compounds containing a substituted or unsubstituted allyl group directly bound to a chiral carbon atom are prepared enantioselectively. Starting reactants are either chiral or achiral, and may or may not contain an attached allyloxycarbonyl group as a substituent. Chiral ligands are employed, along with transition metal catalysts. The methods of the invention are effective in providing enantioconvergent allylation of chiral molecules.Type: GrantFiled: August 29, 2005Date of Patent: June 26, 2007Assignee: California Institute of TechnologyInventors: Douglas C. Behenna, Brian M. Stoltz, Justin T. Mohr, Andrew M. Harned
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Patent number: 7166749Abstract: A biotransformation process for preparing chiral aromatic-hydroxy ketones in high yields is described, using 2-hydroxy-3-oxoacid synthase, such as AHAS or TSAS. Optionally substituted arylaldehydes and -oxoacids react in this process to provide pure enantiomers, useful as synthons in the production of various drugs, an example being (R)-phenylacetyl carbinol.Type: GrantFiled: January 23, 2003Date of Patent: January 23, 2007Assignee: Ben-Gurion University of the NegevInventors: David M. Chipman, Ze'ev Barak, Stanislav Engel, Maria Vyazmensky
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Patent number: 7115762Abstract: This invention relates to a recyclable palladacycle catalyst of formula in which each is a single bond or a double bond, provided that if one is a double bond, its neighboring is not a double bond; each of X and Z, independently, is —P(R?)—, —S—, —N(R?)—, or —N?, in which R? is alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; each of Y1 and Y2, independently, is an anion of an organic or inorganic acid; each of X1, X2, X3, Z1, Z2, and Z3, independently, is —C?, —CR?—, in which R? is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; and each of R1, R2, R3, R4, R5, R6, R7, and R8, independently, is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl, or R1, X, X1, and R2, together form a 3–8 membered ring, or R2, X1, X2, and R3, together form a 3–8 membered ring, or R3, X2, X3, and R4, together form a 3–8 membered ring, or R5, Z, Z1, and R6, together form a 3–8 membered ring, or R6, Z1, Z2, and R7, together form a 3–8 membered ring, or R7, Z2, Z3, and R8, together form a 3–8 membered ring; provided tType: GrantFiled: July 2, 2004Date of Patent: October 3, 2006Assignee: Academia SinicaInventor: Fen-Tair Luo
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Patent number: 7087791Abstract: An ecofriendly process for acylation of an alkylated benzene derivative has increased selectively towards para position and comprises a step of reacting the alkylated benzene derivative with an acylating agent in the presence of nitrobenzene, dichlorobenze, dimethylsulfolane, and/or benzotrile, and a crystalline alumino silicate catalyst having general formula M2/nO.Al2O3.xSiO2.wH2O, wherein M is an alkali cation, a rare earth cation, and/or a proton, wherein the Si/Al ratio is in the range of 5.5 to 20, wherein the step of reacting is performed at temperature between 80° to 140° C. for 5 to 25 hours. In a further step, the solid catalyst is separated from the reaction mixture of step, and in yet another step, the acylated alkyl benzene derivative is separated from the mixture.Type: GrantFiled: October 2, 2003Date of Patent: August 8, 2006Assignee: Council of Scientific and Industrial ReasearchInventors: Raksh Vir Jasra, Beena Tyagi, Yogiraj Mansukhlal Badheka
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Patent number: 6930207Abstract: Novel and known trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds for the treatment and/or inhibition of obesity and of concomitant and/or secondary diseases involved therewith, in particular metabolic syndrome and cardiovascular diseases. Novel trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds, pharmaceutical preparations containing them and processes for the preparation of these compounds. Also compounds acting as inhibitors of lipase, in particular pancreatic lipase.Type: GrantFiled: January 16, 2004Date of Patent: August 16, 2005Assignee: Solvay Pharmaceutical GmbHInventors: Jochen Antel, Harald Waldeck, Andreas Potthoff, Sabine Irmer, Peter-Colin Gregory
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Patent number: 6924397Abstract: The present invention relates to a process for the preparation of ?-chloroketones from readily available alkyl esters by the reaction of a sulfoxonium ylide on said alkyl esters to generate a keto sulfoxonium ylide that is in turn treated with anhydrous HCl.Type: GrantFiled: October 22, 2003Date of Patent: August 2, 2005Assignee: Bristol-Myers Squibb CompanyInventors: William Aloysius Nugent, Dengjin Wang
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Patent number: 6919485Abstract: The invention relates to benzophenones of formula (I), in which the substituents have the following meanings: X represents halogen; R1 represents hydrogen, halogen, C1-C6 alkyl, halo-C1-C2 alkyl, C1-C4 alkoxy, oxyhalomethyl or nitro, and; R2 represents hydrogen, C1-C6 alkyl, benzyl, cyclohexylmethyl or C3-C6 alkenyl.Type: GrantFiled: March 9, 2002Date of Patent: July 19, 2005Assignee: BASF AktiengesellschaftInventors: Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schäfer, Frank Schieweck, Norbert Götz, Karl Eicken, Eberhard Ammermann, Siegfried Strathmann, Gisela Lorenz, Reinhard Stierl
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Patent number: 6881865Abstract: Disclosed is a synthesis method of cyclohexyl phenyl ketone with a high selectivity and a high yield from 1,3-butadiene and acrylic acid in the presence or absence of benzene or a non-aromatic organic solvent in the same reaction without a step of separating or purifying intermediates, the synthesis method including sequentially carrying out a [2+4] Diels-Alder reaction, a hydrogenation reaction, a chlorination reaction and a Friedel-Crafts reaction in the presence/absence of benzene or a non-aromatic organic solvent without separation of intermediates.Type: GrantFiled: July 28, 2003Date of Patent: April 19, 2005Assignee: Korea Kumho Petrochemical Co., Ltd.Inventors: Young J. Joo, Jin Eok Kim, Jeong Im Won, Tae Yi Kang
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Patent number: 6872854Abstract: Metal salts of organic acids complexed with ?-diketone compounds are multifunctional complexes useful in the formulation of stabilizers for halogenated resins. These complexes may be used jointly with other low toxicity intermediates, such as zinc or magnesium intermediates, to form effective stabilizers that are non-toxic and exhibit better performance than other known stabilizers, including those containing toxic heavy metals such as cadmium or lead. The complex is prepared utilizing a Claisen condensation reaction and precipitation with water and heptane.Type: GrantFiled: July 3, 2002Date of Patent: March 29, 2005Assignee: Crompton CorporationInventors: Edward Krainer, Michael H. Fisch, Ulrich Stewen, Radu Bacaloglu, Ilze Bacaloglu
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Patent number: 6864394Abstract: The invention relates to a method for producing ketones by reacting boric acid derivates with carbocylic acid anhydrides in the presence of a transition metal catalyst. The carboxylic acid anhydrides can either be used in isolated form or produced from carboxylic acids in a reaction mixture. This method enables the simple embodiment of a multitude of functionalized ketones in a single reaction step.Type: GrantFiled: May 8, 2002Date of Patent: March 8, 2005Assignee: Studiengesellschaft Kohle mbHInventors: Lukas Goossen, Keya Ghosh
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Patent number: 6852893Abstract: The invention relates to a method for oxidizing substrates such as hydrocarbons, waxes or soot. The method involves the use of a compound of formula (I) in which: R1 and R2 represent H, an aliphatic or aromatic alkoxy radical, carboxyl radical, alkoxycarbonyl radical or hydrocarbon radical, each having 1 to 20 hydrocarbon atoms, SO3H, NH2, OH, F, Cl, Br, I and/or NO2, whereby R1 and R2 designate identical or different radicals or R1 and R2 can be linked to one another via a covalent bonding; Q1 and Q2 represent C, CH, N, CR5, each being the same or different; X and Z represent C, S, CH2, each being the same or different; Y represents O and OH; k=0, 1, 2; l=0, 1, 2; m=1 to 3, and; R5 represents one of the meanings of R1. Said compound is used as a catalyst in the presence of a radical initiator, whereby the molar ratio of the catalyst to the hydrocarbon is less than 10 mol %. Peroxy compounds or azo compounds can be used as the radical initiator. Preferred substrates are aliphatic or aromatic hydrocarbons.Type: GrantFiled: March 22, 2001Date of Patent: February 8, 2005Assignee: Creavis Gesellschaft fuer Technologie and Innovation mbHInventors: Adolf Kühnle, Mark Duda, Carsten Jost, Guido Fries, Jochen Kirchhoff, Thomas Schiffer, Roger Arthur Sheldon, Sasidharan Manickam, Isabella W. C. E. Arends
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Patent number: 6787671Abstract: An osmium-assisted process for the oxidative cleavage of oxidizable organic compounds such as unsaturated organic compounds, including alkenes and olefins into aldehydes, carboxylic acids, esters, or ketones. The process uses a metal catalyst comprising osmium and a peroxy compound selected from the group consisting of peroxymonosulfuric acid and salts thereof to oxidatively cleave the oxidizable organic compound. In particular, the process enables aldehydes, carboxylic acids, esters, or ketones to be selectively produced from the corresponding mono-, 1,1-di-, 1,2-di-, tri-, or tetra-substituted olefins in a reaction that produces the result of ozonolysis but with fewer problems. The present invention further provides a process for oxidizing an aldehyde alone or with the osmium in an interactive solvent to produce an ester or carboxylic acid.Type: GrantFiled: January 13, 2003Date of Patent: September 7, 2004Assignee: Board of Trustees of Michigan State UniversityInventors: Babak Borhan, Benjamin R. Travis, Jennifer M. Schomaker
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Patent number: 6683220Abstract: A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an optically pure metal-organic complex, and a liquid mobile phase preferably containing at least methyl acetate. The liquid mobile phase is preferably free of acetonitrile. The process is operable at temperatures above 40° C.Type: GrantFiled: September 18, 2002Date of Patent: January 27, 2004Assignee: Pfizer, Inc.Inventors: Laurent Berger, Raphael Duval, Philippe Taillasson, Ingo Weber, Alexander Wick
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Publication number: 20040006171Abstract: Metal salts of organic acids complexed with &bgr;-diketone compounds are multifunctional complexes useful in the formulation of stabilizers for halogenated resins. These complexes may be used jointly with other low toxicity intermediates, such as zinc or magnesium intermediates, to form effective stabilizers that are non-toxic and exhibit better performance than other known stabilizers, including those containing toxic heavy metals such as cadmium or lead. The complex is prepared utilizing a Claisen condensation reaction and precipitation with water and heptane.Type: ApplicationFiled: July 3, 2002Publication date: January 8, 2004Inventors: Edward Krainer, Michael H. Fisch, Ulrich Stewen, Radu Bacaloglu, Ilze Bacaloglu
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Patent number: 6642418Abstract: The invention relates to processes for the preparation of compounds of formula (I), wherein R1 and R2 are as defined in the description.Type: GrantFiled: December 4, 2000Date of Patent: November 4, 2003Assignee: Aventis Cropscience SAInventors: Susan Mary Cramp, Neil Jonathan Geach
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Patent number: 6639112Abstract: The invention concerns a method for preparing ketones of formula (I) wherein A and B are as defined in claim 1, consisting of reacting at a temperature ranging between 250 and 500° C. a compound of formula (II): A—X with a compound of formula (III): B—Y, wherein A, B, X and Y are as defined in claim 1, in a coolant solvent having a boiling point higher than 250 ° C.Type: GrantFiled: April 12, 2002Date of Patent: October 28, 2003Assignee: Rhodia ChimieInventor: Michel Alas
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Patent number: 6617473Abstract: The invention relates to a preparation process for derivatives by catalytic dehydrogenation of dibenzosuberone derivatives.Type: GrantFiled: February 26, 2002Date of Patent: September 9, 2003Assignee: Haarman & Reimer GmbHInventors: Stefan Lambrecht, Horst Surburg
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Patent number: 6608217Abstract: The present invention relates to a first process for producing a 2,2-bis(fluoromethyl)-6-(perfluoroalkyl)-2H-1-benzopyran-4-carboxylic acid. The first process includes the steps of (a) reacting a 2,2-bis(fluoromethyl)-6-(perfluoroalkyl)-2H-1-benzopyran-4-one with a perfluoroalkanesulfonic acid anhydride in the presence of a base, thereby obtaining a perfluoroalkanesulfonic 2,2-bis(fluoromethyl)-6-(perfluoroalkyl)-2H- 1-benzopyran-4-yl ester; and (b) reacting the benzopyranyl ester with carbon monoxide in the presence of a palladium complex compound and a base, thereby obtaining the carboxylic acid. The present invention further relates to a second process for producing a 2-hydroxy-5-(perfluoroalkyl) acetophenone, which can be a raw material for producing the carboxylic acid.Type: GrantFiled: September 26, 2002Date of Patent: August 19, 2003Assignee: Central Glass Company, LimitedInventors: Takeo Komata, Masaki Fujiwara, Takanao Tarui, Yusuke Saito, Hiroshi Minesaki
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Publication number: 20030144524Abstract: The invention concerns a condensation method for at least a carbonyl compound bearing at least an electroattractive group on an aromatic derivative bearing at least a hydroxyl function, characterised in that the electroattractive group present on the carbonyl compound is selected among fluoroalkyl derivatives, esters including orthoesters and nitriles and said condensation is carried out in a basic medium.Type: ApplicationFiled: February 27, 2003Publication date: July 31, 2003Applicant: Rhodia Chimie, FranceInventors: Roland Jacquot, Michel Spagnol
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Patent number: 6593499Abstract: The present invention relates to a process for the preparation of phenyl ketones of formula-I, Wherein R represents —COCH3, —COC2H5 or —COC6H5, which comprises acylating the biphenyl with an acylating agent in an organic solvent in the presence of a solid crystalline microporous calalyst composite material.Type: GrantFiled: August 29, 2001Date of Patent: July 15, 2003Assignee: Council of Scientific & Industrial ResearchInventors: Mandan Chidambaram, Chithravel Venkatesan, Anand Pal Singh, Arumugamangalam Venkataraman Ramaswamy
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Publication number: 20030060666Abstract: A process for preparing an &agr;-haloketone of the formula (1) 1Type: ApplicationFiled: September 3, 2002Publication date: March 27, 2003Inventors: Dieter Heldmann, Juergen Stohrer
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Patent number: 6506942Abstract: The invention relates to a process for the preparation of a carbonyl compound of the general formula (1) R1R2C═O (1), in which a &bgr;-hydroxycarboxylic acid or its salt of the general formula (2) R1R2C(OH)—CR3R4—COOM (2) is cleaved in the presence of a Brönstedt base which is selected from hydroxides, alkanolates, oxides, amides and hydrides of the alkali metals and alkaline earth metals, and in the presence of a hydroxyl-free solvent, R1, R2, R3, R4 and M having the meanings from claim 1.Type: GrantFiled: October 12, 2001Date of Patent: January 14, 2003Assignee: Consortium Fur Elektrochemische Industrie GmbHInventors: Klas Sorger, Hermann Petersen, Juergen Stohrer
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Patent number: 6492539Abstract: a process for the preparation of indanones of the formula II from, indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia with a coupling component.Type: GrantFiled: September 1, 1999Date of Patent: December 10, 2002Assignee: Basell Polypropylen GmbHInventors: Carsten Bingel, Markus Goeres, Volker Fraaije, Andreas Winter
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Patent number: 6486356Abstract: A process for preparing a compound of the formula: which comprises reacting a compound of the formula: wherein R1 is C1-6 straight- or branched-chain alkyl, with a compound of the formula: in an aprotic solvent in the presence of base.Type: GrantFiled: March 28, 2000Date of Patent: November 26, 2002Assignee: Rhone-Poulenc AgroInventors: Didier Bernard, Michel Casado, Virginie Pevere, Alain Truchon
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Patent number: 6444854Abstract: A process for the production of enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using continuous chuomatography. The chromatography comprises a liquid mobile phase comprising at least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide that is selected from amylosic, cellulosic, chitosan, xylan, curdlan, and inulan class of polysaccharide.Type: GrantFiled: May 1, 2001Date of Patent: September 3, 2002Assignee: Chiral Technologies EuropeInventors: Oliver Dapremont, Fiona Geiser, Tong Zhang, Subramanian S. Guhan, Robert M. Guinn, George J. Quallich
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Patent number: 6441244Abstract: The invention relates to new compounds of the formula (I) in which R is phenyl, C1-4alkyl-, C1-4alkoxy- or halogen-substituted phenyl, naphthyl or an aromatic ring containing heteroatoms; X is O or S; R1 and R2 are each a methyl radical or R1 and R2 together are a C4-8alkylene radical; Y is hydroxyl, C1-12alkoxy, C1-4alkylamino, di-C1-4alkylamino or a piperidine or morpholine ring that is attached by its nitrogen atom; to a process for preparing them and to their use as photoinitiators and/or photosensitizers.Type: GrantFiled: July 12, 2001Date of Patent: August 27, 2002Assignee: Clariant Finance (BVI) LimitedInventors: Lajos Avar, René Bär, Victor Sanahuja
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Patent number: 6429339Abstract: A process for preparing cyclopentanone by reacting adipic esters of the formula R1OOC—(CH2)4—COOR2 I where R1 and R2 are each alkyl having from 1 to 12 carbon atoms, cycloalkyl having 5 or 6 carbon atoms, aralkyl or aryl and R2 may additionally be hydrogen, in the presence of oxidic catalysts comprises reacting adipic esters of the formula I having less than 5% by weight of by-products other than adipic esters in the gas phase in the presence of water, a carrier gas and a) from 0.01 to 10% by weight of at least one metal oxide selected from the first or second main group of the periodic table or from the group of the rare earth metals on titanium dioxide or zirconium dioxide as catalyst support, or b) from 0.01 to 50% by weight of at least one metal oxide selected from the second main group of the periodic table on zink oxide as catalyst support.Type: GrantFiled: November 15, 2000Date of Patent: August 6, 2002Assignee: BASF AktiengesellschaftInventors: Shelue Liang, Rolf Fischer, Frank Stein, Joachim Wulff-Döring