Unsaturation In The Ring Patents (Class 568/377)
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Publication number: 20120196182Abstract: The present invention provides a positive electrode active material for nonaqueous solvent secondary batteries, comprising, as an active ingredient, a 1,4-benzoquinone compound having lower alkoxy groups as substitutes, and a nonaqueous secondary battery comprising the positive electrode active material as a constituent. According to the invention, a nonaqueous secondary battery having a high energy density and excellent cycle characteristics can be obtained by using a positive electrode active material composed of an organic compound with a low environmental load.Type: ApplicationFiled: October 26, 2010Publication date: August 2, 2012Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLGOYInventors: Masaru Yao, Hiroshi Senoh, Kazuaki Yasuda
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Publication number: 20120189600Abstract: The present invention relates to compositions and methods for treating neurodegenerative diseases. In some embodiments, the present invention provides compositions for treating and preventing presbycusis.Type: ApplicationFiled: March 21, 2012Publication date: July 26, 2012Applicant: MARINE BIO CO., LTD.Inventor: Shinichi Someya
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Publication number: 20120122994Abstract: An object of the present invention is to provide a new insecticidal compound by paying attention to the insecticidal activity contained in the flower part of marigold, and to provide an insecticide containing the compound as an active ingredient. There are provided an insecticidal compound represented by the following chemical formula: [Formula 1], and an insecticide containing the insecticidal compound as an active ingredient or an insecticide containing, as active ingredients, the insecticidal compound and an insecticidal compound represented by the following chemical formula: [Formula 2], wherein the insecticide can exhibit extraordinary insecticidal efficacy compared with existing pyrethroid-based insecticidal compounds.Type: ApplicationFiled: August 31, 2011Publication date: May 17, 2012Inventors: Yoshio KATSUDA, Masafumi INOUE, Masamichi OKAMOTO
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Publication number: 20120101169Abstract: The present invention is directed to methods of providing anticoagulation effects in subjects in need thereof, comprising administering to the subjects at least twice a day compounds of the present invention, stereoisomers, and racemates thereof.Type: ApplicationFiled: July 11, 2011Publication date: April 26, 2012Applicant: Penwest Pharmaceuticals Co.Inventor: Amale HAWI
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Publication number: 20120059194Abstract: Disclosed are a production method for a ubiquinone powder for use in preparations, including Step 1 of compression molding a ubiquinone crystal powder at a linear molding pressure of from 0.6 to 2.5 tons/cm to obtain a compressed fragment; and Step 2 of grinding the compressed fragment obtained in Step 1 to obtain a powder; and a ubiquinone powder for use in preparations, which is obtained by the subject production method. According to the subject production method, it becomes possible to provide a ubiquinone powder for use in preparations for medicines and health foods, which has a high bulk density, a small angle of repose and excellent handling properties and fluidity, without using an additive such as an excipient, a binder and the like.Type: ApplicationFiled: March 29, 2010Publication date: March 8, 2012Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Takafumi Yoshimura, Rieko Nakano, Masayuki Furutani, Takeshi Uchiho
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Patent number: 8124811Abstract: The present invention is directed to novel methods for production of 5-epi-?-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. In one embodiment the present invention describes a method for production of 5-epi-?-vetivone by the use of premnaspirodiene as starting material. In another embodiment the present invention describes a method for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one by the use of premnaspirodiene as starting material. In yet another embodiment the present invention describes a novel method for production of premnaspirodiene from a terpene substrate. Use of the fragrant components or any composition containing the component can be advantageously employed in the perfumery industry.Type: GrantFiled: October 14, 2009Date of Patent: February 28, 2012Assignee: Allylix, Inc.Inventors: Bryan N. Julien, David M. Wallace
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Patent number: 8093204Abstract: The present invention relates to compounds useful as fragrance ingredients of formula (I) wherein the bond between C-1 and C-2 is a single bond and the dotted line together with the bond between C-2 and C-3 represents a double bond; or the bond between C-2 and C-3 is a single bond and the dotted line together with the bond between C-1 and C-2 represents a double bond.Type: GrantFiled: June 3, 2008Date of Patent: January 10, 2012Assignee: Givaudan SAInventors: Thierry Granier, Andreas Hanhart, Jerzy A. Bajgrowicz
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Publication number: 20120004319Abstract: The present invention provides a method for producing a carotenoid-containing composition, comprising the steps of: subjecting a culture of a carotenoid-producing microorganism to an extraction treatment using a water-soluble organic solvent; dispersing the resulting extract solution in water for micellization; heat stirring the resulting micellized solution in a solvent break the micelles and precipitate the carotenoid component of interest to obtain the precipitate; collecting and heat washing the precipitate with ethanol; and further subjecting the precipitate to pulverization/drying; and food, a pharmaceutical composition and a cosmetic product comprising the carotenoid-containing composition.Type: ApplicationFiled: March 1, 2010Publication date: January 5, 2012Inventors: Kentaro Shimizu, Tomoyuki Ishizaki, Toshiyuki Takahashi, Shotaro Uchizawa
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Patent number: 8084649Abstract: Cyclohexanedione compounds, and derivatives thereof, which are substituted in 5-position, are suitable for use as herbicides. The cyclohexanedione compounds and derivatives of the invention are compounds of formula (I) wherein the substituents are as defined in the description.Type: GrantFiled: March 7, 2008Date of Patent: December 27, 2011Assignee: Syngenta Crop Protection, inc.Inventors: Michel Muehlebach, William Lutz, Jean Wenger, John Finney, Christopher John Mathews, Delphine Raymonde Suzanne Fawke
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Publication number: 20110308555Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.Type: ApplicationFiled: June 22, 2011Publication date: December 22, 2011Inventors: Johan SMETS, Hugo Robert Germain Denutte, An Pintens, Koen Van Aken, Freek Annie Camiel Vrielynck
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Patent number: 8071529Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octene and -octane compounds of the present invention are represented by formula: wherein R is selected from the group consisting of hydrogen, acetate, carbonate monomethyl ester, and allyloxy; and wherein the broken line represents a single or double bond.Type: GrantFiled: October 8, 2010Date of Patent: December 6, 2011Assignee: International Flavors & Fragrances Inc.Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
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Publication number: 20110172312Abstract: The present invention relates to methods of treating Leigh Syndrome and Leigh-like Syndrome with tocotrienol quinones, including alpha-tocotrienol quinone, in order to alleviate symptoms of the disease.Type: ApplicationFiled: December 30, 2010Publication date: July 14, 2011Inventors: Guy M. MILLER, Martin J. Thoolen
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Publication number: 20110158921Abstract: The present invention provides methods of treating humans and animals with terpenes and terpenoids in order to rejuvenate the skin and increase the protective layer against irradiation by ultraviolet radiation (UVR). More specifically it provides terpenes and terpenoids as ingredients that work as persistent UVR blockers. Terpenes and terpenoid compounds support the growth of skin, skin tissue and keratinocytes and additional UVR-blocking by reason of increased stratum corneum thickness and loricrin content. Both terpenes and terpenoids may be applied topically or orally at oral or topical concentrations from about 6 mg to about 600 mg per kilogram of body weight per day effective to stimulate growth of the skin layer and prevent damage from ultraviolet radiation (UVR).Type: ApplicationFiled: September 17, 2010Publication date: June 30, 2011Inventors: Ivica Labuda, Fredric Jay Burns
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Publication number: 20110104137Abstract: Dosage forms and methods of use are disclosed for a) adjuncts administered individually or simultaneously with HMg-CoA reductase inhibitors (statins) and/or selective phosphodiesterase 5 inhibitors or, b) the administration of a conjugate consisting of the adjuncts and an HMG-CoA reductase inhibitor and/or a selective phosphodiesterase 5 inhibitor. The invention is useful in the amelioration of side effects associated with HMG-CoA reductase inhibitors and will improve their effectiveness in diseases for which these are useful. The invention will also improve the effectiveness in the of selective phosphodiesterase 5 inhibitors in patients using these medications alone or in conjunction with statins, for the treatment of erectile dysfunction.Type: ApplicationFiled: April 19, 2010Publication date: May 5, 2011Applicant: ChronoRX LLC, an Alaska Limited Liability CompanyInventors: Kenneth T. Richardson, Don C. Pearson
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Publication number: 20110028750Abstract: The present invention concerns a process for the preparation of a compound of formula (I) wherein R represents a Me or Et group, as well said compound in the form of any one of its stereoisomers or mixture thereof. The invention concerns also the use of compound (I) for the synthesis of ?-santalol or of derivatives thereof.Type: ApplicationFiled: May 18, 2009Publication date: February 3, 2011Applicant: Firmenich SAInventors: Charles Fehr, Magali Vuagnoux
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Publication number: 20110014143Abstract: The present invention relates to the field of perfumery and concerns the use as perfuming ingredient of ketones of formula wherein n represents 0, 1 or 2, m represents 0, 1 or 2, the dotted lines represent only single bonds or one double bond and two single bonds, R1 represents a hydrogen atom or a methyl or ethyl group, said R1 group being located at any of the position of the cyclic moiety, R2 represents a C1-C3 O-alkyl or O-alkenyl group or a substituted or unsubstituted ethylene or cyclopropyl group. Said compounds are useful to impart a clean and natural fruity, pineapple odor type. The present invention concerns also the compositions or articles containing said compounds (I) as well as some of said compounds (I).Type: ApplicationFiled: April 14, 2009Publication date: January 20, 2011Applicant: Firmenich SAInventors: Christian Chapuis, Anthony Birkbeck, Maurus Marty
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Publication number: 20100317742Abstract: As described below, the present invention provides methods and compositions for controlling a honey bee parasitic mite. In addition, the invention features compositions useful for the treatment or prevention of a parasitic mite infestation in a honey bee hive.Type: ApplicationFiled: August 2, 2010Publication date: December 16, 2010Inventor: Gene Probasco
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Publication number: 20100312016Abstract: The present invention relates to a process for the preparation of ?-ionones and/or ?-ionones of the formulae (II) and (III) by acid catalyzed ring-closing of ?-ionone of the formula (I) wherein R1 to R7 are independently selected from hydrogen and C1-C4-alkyl, R8 is selected from hydrogen and C1-C4-alkyl and the hydroxyl group, R9 and R10 are independently selected from hydrogen and C1-C4-alkyl or R9 and R10 form together the oxygen of a carbonyl group, whereby if R9 and R10 form together the oxygen of a carbonyl group no ?-isomer is formed comprising: a) reacting a ?-ionone according to formula (I) in presence of a concentrated Brønsted-acid having a pKs<3, and an organic solvent that is substantially immiscible with the concentrated acid and with an diluted aqueous solution of said acid; b) hydrolysis of the reaction product obtained in step a) by addition of water; and phase separation into an organic phase comprising the ?-ionone and/or the ?-ionone of the formulae (II) and (III) and into an aqueous diType: ApplicationFiled: November 12, 2007Publication date: December 9, 2010Inventors: Andreas Luettin, Claude Stritt
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Publication number: 20100310478Abstract: An alkyl- or halo-substituted benzoquinone, hydroquinone or mixture thereof, for use in the treatment of a periodontal disease, and/or for use in the treatment of a condition which is caused by, transmitted by or exacerbated by P. gingivalis or by biofilm formation by P. gingivalis.Type: ApplicationFiled: December 11, 2008Publication date: December 9, 2010Inventors: Daniel James Fitzgerald, Nicholas Edward Read, Priscila Gottardello, Stephen Philip Jones
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Publication number: 20100273893Abstract: The present invention refers to thymoquinone, a main constituent of the volatile oil of Nigella sativa, and its protective effect against sepsis syndrome morbidity, mortality and associated organ dysfunctions. In particular, the present invention refers to thymoquinone for use in the prevention and/or treatment of sepsis syndrome. The present invention further refers to a pharmaceutical composition and a kit.Type: ApplicationFiled: September 16, 2009Publication date: October 28, 2010Inventors: Khalid M. Alkharfy, Nasser M. Al-Daghri, Omar S. Al-Attas, Majed S. Alokail
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Patent number: 7812195Abstract: The present invention relates to substituted cyclohexenyl butenones of the formula wherein R1, R2, R3, R4 and R5 are independently selected from hydrogen, methyl or ethyl; and the total sum of carbon atoms is 11 to 15; as well as to a method for their production and to fragrance compositions and fragrance applications comprising them.Type: GrantFiled: December 11, 2007Date of Patent: October 12, 2010Assignee: Givaudan SAInventors: Thierry Granier, Andreas Hart, Jerzy A. Bajgrowicz
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Publication number: 20100237298Abstract: The present invention is concerned with novel compounds derived from polyquinonic ionic compounds and their use in electrochemical generators.Type: ApplicationFiled: June 2, 2010Publication date: September 23, 2010Inventors: Michel Armand, Christophe Michot, Nathalie Ravet
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Publication number: 20100223841Abstract: Fuel additives, fuel formulations, and processes for their preparation and use are provided. The additives improve the combustion properties of hydrocarbon fuels. The enhanced combustion indicates reductions in certain emissions.Type: ApplicationFiled: April 5, 2010Publication date: September 9, 2010Applicant: Oryxe Energy International, Inc.Inventors: Fredrick L. Jordan, Geoffrey E. Dolbear
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Publication number: 20100216981Abstract: An object of the present invention is to provide a viral disease control agent which has a mechanism of action different from conventional one as a substitute for existing viral disease control methods and is used in more practical and safer manners. The present invention utilizes a compound having inhibitory activity on the binding of a substance ? to a PTGS suppressor protein, wherein the substance ? has a property of inducing PTGS and a property of binding to the PTGS suppressor protein and shows a decrease in the property of inducing PTGS upon binding to the PTGS suppressor protein.Type: ApplicationFiled: March 19, 2008Publication date: August 26, 2010Applicants: Nippon Soda Co., Ltd., Hokkaido UniversityInventors: Shinsuke Sano, Takako Fukagawa, Hirokazu Yamada, Chikara Masuta, Hanako Shimura
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Publication number: 20100179061Abstract: A plant-growth-promoting agent is provided, which is lower in environmental pollution, highly safe and harmless to human bodies, and which exhibits an excellent plant growth-promoting action even under wide temperature conditions from low temperatures to high temperatures. A plant growth-promoting agent is also provided, which has an ability to store ubiquinone, as an active ingredient of the plant-growth-promoting agent, in a stable state and can be dispersed and stably present in a medium such as a soil or an aqueous liquid which supplies nutrition to the plant, especially in an initial stage in which a plant body is grown after germination.Type: ApplicationFiled: May 29, 2008Publication date: July 15, 2010Applicant: Nisshin Pharma Inc.Inventor: Yutaka Saito
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Publication number: 20100173774Abstract: Cyclohexanedione compounds, and derivatives thereof, which are substituted in 5-position, are suitable for use as herbicides.Type: ApplicationFiled: March 7, 2008Publication date: July 8, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Michel Muehlebach, William Lutz, Jean Wenger, John Finney, Christopher John Matthews, Delphine Fawke
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Publication number: 20100173821Abstract: The present invention relates to 1-(2-isobutylcyclohex-1-enyl)but-2-en-1-one and 1-(2-isobutylcyclohex-2-enyl)but-2-en-1-one and their use as fragrance ingredient.Type: ApplicationFiled: June 3, 2008Publication date: July 8, 2010Applicant: GIVAUDAN SAInventors: Thierry Granier, Andreas Hanhart, Jerzy Bajgrowicz
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Publication number: 20100168440Abstract: Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.Type: ApplicationFiled: February 9, 2010Publication date: July 1, 2010Applicant: Takasago International CorporationInventors: Hideo SHIMIZU, Daisuke Igarashi, Wataru Kuriyama, Yukinori Yusa
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Publication number: 20100137595Abstract: Use vaginal odorant compounds for controlling motile cell chemotaxis.Type: ApplicationFiled: June 27, 2008Publication date: June 3, 2010Applicant: Fraunhofer-Gesellshcaft zur Forderung der angewandten Forschung e.V.Inventor: Andrea Büttner
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Publication number: 20100137178Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.Type: ApplicationFiled: December 1, 2009Publication date: June 3, 2010Inventors: Johan Smets, Hugo Robert Germain Denutte, An Pintens, David Thomas Stanton, Koen Van Aken, Inge Helena Hubert Laureyn, Bram Denolf, Freek Annie Camiel Vrielynck
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Publication number: 20100129306Abstract: The present invention is directed to novel methods for production of 5-epi-?-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. In one embodiment the present invention describes a method for production of 5-epi-?-vetivone by the use of premnaspirodiene as starting material. In another embodiment the present invention describes a method for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one by the use of premnaspirodiene as starting material. In yet another embodiment the present invention describes a novel method for production of premnaspirodiene from a terpene substrate. Use of the fragrant components or any composition containing the component can be advantageously employed in the perfumery industry.Type: ApplicationFiled: October 14, 2009Publication date: May 27, 2010Inventors: Bryan N. Julien, David M. Wallace
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Publication number: 20100094061Abstract: The present invention relates to an agent for suppressing STATS phosphorylation and for suppressing Notch1 expression comprising as an active ingredient a compound represented by the following formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group; and X represents a linear or branched alkyl, alkylene or alkenylene group having 10 to 28 carbon atoms.Type: ApplicationFiled: October 13, 2005Publication date: April 15, 2010Applicant: Meiji Dairies CorporationInventors: Bang Luu, Ellane Mohier, Masashi Yamada, Hiroto Suzuki
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Patent number: 7674765Abstract: The invention relates to a method for producing cyclohexadecanone by hydrogenating cyclohexadecenone, to mixtures of aromatic substances, and to products containing the inventive cyclohexadecanone.Type: GrantFiled: May 22, 2003Date of Patent: March 9, 2010Assignee: Symrise GmbH & Co., KGInventors: Ingo Wöhrle, Walter Kuhn, Hans-Ulrich Funk, Alfred Körber
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Publication number: 20100028318Abstract: The present invention has its object to provide a safer and highly effective composition capable of relieving or preventing xerostomia. The present invention relates to an agent for relieving or preventing xerostomia comprising an oxidized coenzyme Q and/or a reduced coenzyme Q as active ingredients, a composition containing the agent for relieving or preventing xerostomia in a form of a food product, a health food, a dietary supplement, a supplement, an oral health care product, a medicament, a quasi drug, a pet food, a feed or the like, and a method for treating xerostomia and a method for reducing risks of xerostomia comprising administering the composition.Type: ApplicationFiled: January 31, 2008Publication date: February 4, 2010Applicants: KANEKA CORPORATIONInventors: Ichiro Saito, Kenji Fujii, Kazuya Hamada
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Publication number: 20100016197Abstract: The present invention relates to substituted cyclohexenyl butenones of the formula wherein R1, R2, R3, R4 and R5 are independently selected from hydrogen, methyl or ethyl; and the total sum of carbon atoms is 11 to 15; as well as to a method for their production and to fragrance compositions and fragrance applications comprising them.Type: ApplicationFiled: December 11, 2007Publication date: January 21, 2010Inventors: Thierry Granier, Andreas Hart, Jerzy A. Bajgrowicz
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Patent number: 7605183Abstract: A method for inhibiting or blocking molecular generating and/or inducing functions of molecules using an inhibitory or blocking agent of the formula: wherein R1-6 are as defined herein.Type: GrantFiled: August 9, 2007Date of Patent: October 20, 2009Inventors: Shozo Koyama, Yoshihiro Yamaguchi
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Publication number: 20090216015Abstract: The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of strong basis.Type: ApplicationFiled: January 4, 2006Publication date: August 27, 2009Applicant: The Queen's University of BelfastInventors: Martyn J. Earle, Ute Frohlich, Susanne Huq, Suhas Katdare, Rafal Marcin Lukasik, Ewa Bogel, Natalia Vladimirovna Plechkova, Kenneth Richard Seddon
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Patent number: 7569733Abstract: The invention relates to a compound of the formula (VII) to an odoriferous substance or aroma composition comprising such a compound, and to a perfumed or aromatized product comprising such a compound. The invention furthermore relates to the use of a compound of the formula (VII) as an odoriferous substance and/or for improving fixation of an odoriferous substance or aroma composition. The invention moreover relates to a method for producing a compound of the formula (VII), to a method for producing a precursor of the compound of the formula (VII) and to the precursor itself. It moreover relates to a method for producing, enhancing or modifying a sandalwood odor in a mixture.Type: GrantFiled: September 12, 2008Date of Patent: August 4, 2009Assignee: Symrise GmbH & Co. KGInventors: Constanze Brocke, Marcus Eh, Egon Oelkers
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Patent number: 7547697Abstract: Compounds of formula (I): as well as pharmaceutically acceptable salts and esters thereof for use as pharmaceutical compositions.Type: GrantFiled: July 2, 2007Date of Patent: June 16, 2009Assignee: Hoffmann-La Roche Inc.Inventors: Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Werner Neidhart, Alexander V. Mayweg
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Publication number: 20090069442Abstract: The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group]. The cyclohexenone long chain alcohol of the present invention improves hyperalgesia or hypoalgesia, and thus is useful as therapeutic agents for sensory disorders. Sensory disorders that can be prevented or treated by the present invention include chronic intractable pain, neurogenic pain, reduction of pain threshold caused by nerve injuries, hypesthesia or hyperesthesia caused by diabetes and nerve injuries, and the like.Type: ApplicationFiled: January 18, 2006Publication date: March 12, 2009Inventors: Hirohito Shiomi, Yutaka Tamura, Bang Luu, Masashi Yamada, Keizou Koyama, Hiroto Suzuki
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Patent number: 7501454Abstract: The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.Type: GrantFiled: July 31, 2007Date of Patent: March 10, 2009Assignee: Golden Biotechnology CorporationInventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
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Publication number: 20090054299Abstract: Unsaturated ketones of general formula (I) where the groups R1, R2, R3, R4 and R5 independently=H or 1-6 C alkyl groups, which can be saturated or unsaturated, straight-chained, branched or cyclic are characerised by an interesting and original odour characteristic with good emanation and are suitable for use as perfumes, for example in cosmetic preparations, technical products or alcoholic perfumery.Type: ApplicationFiled: November 3, 2008Publication date: February 26, 2009Applicant: KAO CORPORATIONInventors: Thomas MARKERT, Volker Porrmann, Frank Rittler
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Patent number: 7468392Abstract: The present invention relates to a compound of Antrodia camphorata used to delay physiological fatigue, in particular to a extract isolated from Antrodia camphorata, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6-10-trienyl)-cyclohex-2-enone, and its use in delaying fatigue. Immediate supplementation of the compound according to the invention after high intensity exhausted exercise at 80% VO2max can promote the metabolism of creatine phosphate kinase and blood ammonia in human bodies, be beneficial to their recovery, further achieves the function in delaying physiological fatigue.Type: GrantFiled: July 27, 2007Date of Patent: December 23, 2008Assignee: Golden Biotechnology CorporationInventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
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Publication number: 20080312334Abstract: The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.Type: ApplicationFiled: July 31, 2007Publication date: December 18, 2008Applicant: Golden Biotechnology CorporationInventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
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Publication number: 20080312474Abstract: The present invention relates to a compound of Antrodia camphorata used to delay physiological fatigue, in particular to a extract isolated from Antrodia camphorata4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, and its use in delaying fatigue. Immediate supplementation of the compound according to the invention after high intensity exhausted exercise at 80%VO2max can promote the metabolism of creatine phosphate kinase and blood ammonia in human bodies, be beneficial to their recovery, further achieves the function in delaying physiological fatigue.Type: ApplicationFiled: July 27, 2007Publication date: December 18, 2008Inventors: Sheng-Yun LIU, Mao-Tien Kuo, Wu-Che Wen
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Publication number: 20080312335Abstract: The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorate. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPX) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.Type: ApplicationFiled: September 24, 2007Publication date: December 18, 2008Inventors: Sheng-Yun Liu, Wu-Che Wen, Mao-Tien Kuo
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Patent number: 7456225Abstract: The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPx) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.Type: GrantFiled: September 24, 2007Date of Patent: November 25, 2008Assignee: Golden Biotechnology CorporationInventors: Sheng-Yun Liu, Wu-Che Wen, Mao-Tien Kuo
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Patent number: 7432305Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed.Type: GrantFiled: September 15, 2006Date of Patent: October 7, 2008Assignee: Edison Pharmaceuticals, Inc.Inventors: Guy M. Miller, Sidney M. Hecht
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Publication number: 20080226983Abstract: The invention provides a non-aqueous electrolyte including: at least one kind selected from the compounds represented by Chemical formula 1: wherein R1 and R2 each represent a hydrogen group, a hydrocarbon group or an alkylsilyl group, or any of these groups part or all of the hydrogen atoms of which is/are substituted with a halogen, R1 and R2 may be bonded to each other, and n is an integer of 1 or larger.Type: ApplicationFiled: March 14, 2008Publication date: September 18, 2008Applicant: SONY CORPORATIONInventors: Toru Odani, Tadahiko Kubota
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Patent number: RE43280Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.Type: GrantFiled: April 18, 2003Date of Patent: March 27, 2012Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati