Five-membered Alicyclic Ring Containing Patents (Class 568/379)
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Patent number: 7439378Abstract: The present invention relates to a novel fulvene compound and a preparation method thereof, and more particularly to a fulvene compound having substituted groups in the 2- and 5-positions, prepared from an unsaturated ketone having a substituted group in the ?-position and a halogen atom in the ?-position, and a preparation method thereof. The present invention also relates to a metallocene catalyst having a substituted group in the ?-position carbon of the bridge of the cyclopentadienyl group only by reaction of a fulvene compound and an anion group including the cyclopentadienyl group, and a preparation method of a polyolefin copolymer using the same.Type: GrantFiled: March 15, 2007Date of Patent: October 21, 2008Assignee: LG Chem, Ltd.Inventors: Young-Whan Park, Si-Geun Lee, Sung-Don Hong, Kwang-Ho Song, Boong-Goon Jeong, Dae-Woo Nam, Bun-Yeol Lee, Choong-Hoon Lee, Hyo-Sun Lee
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Publication number: 20080255367Abstract: The present invention discloses processes for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates.Type: ApplicationFiled: December 21, 2007Publication date: October 16, 2008Inventors: Thomas D. Gordon, Grier A. Wallace, Martin E. Hayes, Kirill A. Lukin, Lei Wang, Dilinie P. Fernando
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Publication number: 20080226983Abstract: The invention provides a non-aqueous electrolyte including: at least one kind selected from the compounds represented by Chemical formula 1: wherein R1 and R2 each represent a hydrogen group, a hydrocarbon group or an alkylsilyl group, or any of these groups part or all of the hydrogen atoms of which is/are substituted with a halogen, R1 and R2 may be bonded to each other, and n is an integer of 1 or larger.Type: ApplicationFiled: March 14, 2008Publication date: September 18, 2008Applicant: SONY CORPORATIONInventors: Toru Odani, Tadahiko Kubota
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Publication number: 20080138482Abstract: This invention relates to campholenic derivatives of general formula (I) Wherein R1, R2, R3, R4 and R5 represent, each independently, a hydrogen atom or a linear or branched C1-C5 alkyl or C2-C5 alkenyl group, Y represents a CN, a C(O)R6 or a CR6(OR?) (OR?) group, wherein R6 represents a hydrogen atom or a linear or branched C1-C5 alkyl or C2-C5 alkenyl group, and R? and R? represent simultaneously a linear or branched C1, C2, C3, C4 or C5 alkyl or C2, C3, C4 or C5 alkenyl group and can form together a cycle, the 5-membered ring is saturated or has a double bond between C3? and C4? in formula (I), and the side chain, optionally, has a double bond between C1 and C2 and/or between C3 and C4, provided that the derivative is not 3-methyl-6-(2,2,3-trimethyl-cyclopent-3-enyl)-hex-4-enal; and their use as fragrant or flavouring agent.Type: ApplicationFiled: December 10, 2007Publication date: June 12, 2008Applicant: V. MANE FILSInventors: Jean Mane, Caroline Plessis, Jean-Jacques Chanot
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Patent number: 7345204Abstract: The present invention relates to substituted cyclopentanone derivatives and their use as fragrance chemicals suitable for incorporation in fine fragrances, cosmetics, toiletries and related applications.Type: GrantFiled: May 23, 2006Date of Patent: March 18, 2008Assignee: International Flavors & Fragrances IncInventors: Anthony T. Levorse, Jr., Richard A. Weiss, Brett D. Newirth
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Patent number: 7321057Abstract: The present invention provides a new method for manufacturing a prostaglandin analogue having one or more keto groups on the 5-membered ring and/or omega chain, which comprises the step of treating a corresponding hydroxyl group containing compound with a co-oxidizer under the presence of a tetramethylpyperidine-1-oxyl derivative to form the desired prostaglandin analogue. The method of the invention can be carried out easily under relatively mild conditions.Type: GrantFiled: August 1, 2005Date of Patent: January 22, 2008Assignee: R-Tech Ueno, Ltd.Inventors: Ryu Hirata, Tatsuya Matsukawa
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Patent number: 7271277Abstract: The present invention relates to a novel fulvene compound and a preparation method thereof, and more particularly to a fulvene compound having substituted groups in the 2- and 5-positions, prepared from an unsaturated ketone having a substituted group in the ?-position and a halogen atom in the ?-position, and a preparation method thereof. The present invention also relates to a metallocene catalyst having a substituted group in the ?-position carbon of the bridge of the cyclopentadienyl group only by reaction of a fulvene compound and an anion group including the cyclopentadienyl group, and a preparation method of a polyolefin copolymer using the same.Type: GrantFiled: August 29, 2003Date of Patent: September 18, 2007Assignee: LG Chem, Ltd.Inventors: Young-Whan Park, Si-Geun Lee, Sung-Don Hong, Kwang-Ho Song, Boong-Goon Jeong, Dae-Woo Nam, Bun-Yeol Lee, Choong-Hoon Lee, Hyo-Sun Lee
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Patent number: 7227044Abstract: The present invention relates to a cycloalkanone composition which contains cycloalkanone (1) in an amount of 70 wt % or more based on the composition, wherein the content of a dimer of a cycloalkanone represented by formula (2) is 0.055 or less in terms of weight ratio to the cycloalkanone (1), a process for producing the same, a process for producing a composition containing alkyl acetate (5) by using the cycloalkanone composition, and an alkyl acetate composition obtained by the process wherein n is an integer of 1 or 2, R1 and R2 each represent H, a C1 to C8 alkyl group etc., and R3 represents a C1 to C3 alkyl group.Type: GrantFiled: March 11, 2005Date of Patent: June 5, 2007Assignee: Kao CorporationInventor: Koji Mine
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Patent number: 7183440Abstract: A compound of formula (I) or (II): wherein A is hydrogen or CR1R2; Y and Z are each, independently, hydrogen or a halogen; X is —NR4R5, or R7; R1 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1–4 carbon atoms; when X is —NR4R5, R2 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; when X is R7, R2 is an unsubstituted alkyl, alkenyl or alkynyl group, or a substituted or unsubstituted aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; R3 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; R4 is hydrogen, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkylType: GrantFiled: February 7, 2005Date of Patent: February 27, 2007Assignee: Charterhouse Therapeutics LtdInventors: Stanley Michael Roberts, Maria Gabriella Santoro, Vasudev Jadhav, Alan Michael Happe, Jérôme Dauvergne
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Patent number: 7166731Abstract: There are provided a method of simply preparing a 1,4,6-substituted, 1,4-substituted, 1,6-substituted, or 1-substituted fulvene compound, the intermediates of the fulvene compound, and a method of preparing an ansa-metallocene compound in which two cyclopentadienyl ligands are bridged by one carbon and there are substituents only at positions adjacent to the bridging point of a cyclopentadienyl ligand, using the fulvene compound.Type: GrantFiled: October 13, 2004Date of Patent: January 23, 2007Assignee: LG Chem. Ltd.Inventors: Young Whan Park, Hyosun Lee, Sung Don Hong, Kwang Ho Song, Boong Goon Jeong, Dae Woo Nam, Hye Young Jung, Bun Yeoul Lee, Young Chul Won
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Patent number: 7160852Abstract: The compound according to the formula set forth below and the use of the compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products is disclosed.Type: GrantFiled: August 7, 2003Date of Patent: January 9, 2007Assignee: International Flavors & Fragrances IncInventors: Anthony T. Levorse, Jr., Anubhav P. S. Narula, Edward Mark Arruda, Charles E. J. Beck
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Patent number: 7141699Abstract: The present invention relates to substituted cyclopentanone derivatives and their use as fragrance chemicals suitable for incorporation in fine fragrances, cosmetics, toiletries and related applications.Type: GrantFiled: July 1, 2005Date of Patent: November 28, 2006Assignee: International Flavors & Fragrances Inc.Inventors: Anthony T. Levorse, Jr., Richard A Weiss, Brett D. Newirth
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Patent number: 7109380Abstract: Compounds and methods useful in the control, treatment, and prevention of fungal activity, of the following formula: where R1-3 are independently H, alkyl, methyl, acyl, halogen, phenyl, R4 is H, alkyl, methyl, acyl, alkoxy, halogen, phenyl provided that when R3 is methyl and R4 is H, R1 and R2 are not both H; and stereoisomers, analogs, and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 29, 2005Date of Patent: September 19, 2006Assignees: The University of Mississippi, The United States of America as represented by the Secretary of AgricultureInventors: Xing-Cong Li, Melissa R. Jacob, David Wedge
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Patent number: 7026279Abstract: 3-(methoxymethyl)-2-pentylcyclopent derivative compounds having the structure set forth below are disclosed: where: the dotted line represents a potential double bond; R is selected from methyl and ethyl; and X is a C1–C7 hydrocarbon moiety. These compounds are useful fragrance chemicals, suitable for use in creating fragrances and scents in items such as perfumes, colognes and personal care products.Type: GrantFiled: June 24, 2004Date of Patent: April 11, 2006Assignee: International Flavors & Fragrances Inc.Inventors: Michael G. Monteleone, Matthew John Clements, Louis Croce, Jr., Robert P. Belko, Manfred Pawlak
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Patent number: 6943272Abstract: The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present —CHCH3OH or —CHCH3OCOR or —CHCH3XCH2CHOHR? or —CHCH3OCHR?CH2OH or formula (II) when the dotted line bond is absent —CHCH3OH or —CHCH3OCOR or —COCH3 or formula (II) or —CHCH3XCH2CHOHR? or —CH2CH2XCH2CHOHR? or —CHCH3OCHR?CH2OH or —CHCHCOR? or —CH2CH2CHR?OH or —CH2CH2CHR?OCOR or CHCHCHOHR? or —CHCHCHR?OCOR, wherein R represents H, Me, Et, Pr, isoPr, But, isoBut, CH3CH2)4, (CH3)2CHCH2, CH2CH, (CH3)2CCH, and R? represents H, Me or Et, and X represents O, N or S, and their preparation method. Because of their fragrance, said compounds are highly interesting for the perfume industry, for cosmetic and care products.Type: GrantFiled: October 23, 2002Date of Patent: September 13, 2005Assignee: V. Mane FilsInventors: Jean Mane, Jean-Jacques Chanot, Fabrice Le Borgne, Martin Schroeder
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Patent number: 6903067Abstract: An excellent fragrance compound having high palatability. A 3-(3-hexenyl)-2-cyclopentenone represented by a general formula (1) (wherein wavy line represents a double bond cis-form and/or trans-form) is used as an active ingredient of scent and mixed in a small amount with fragrance compositions, cis-jasmone and/or various materials to be scented. Since the above compound has a characteristic fragrance quality and high palatability, it is markedly useful as a scenting component of various fragrances and cosmetics, sanitation materials and the like.Type: GrantFiled: December 4, 2002Date of Patent: June 7, 2005Assignee: Takasago International CorporationInventors: Hiroyuki Matsuda, Kenji Maruyama
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Patent number: 6787655Abstract: One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, the transition metal catalyst consists essentially of copper and an asymmetric bidentate bisphosphine ligand.Type: GrantFiled: October 15, 2002Date of Patent: September 7, 2004Assignee: Massachusetts Institute of TechnologyInventors: Stephen L. Buchwald, Daniel H. Appella, Yasunori Moritani, Ryo Shintani, Valdas Jurkauskas
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Patent number: 6717017Abstract: The present invention provides a method of synthesizing compounds of formula (I) or (II): wherein R1 is hydrogen, R′ is (C1-C4)alkyl and X is a hydroxyl protecting group.Type: GrantFiled: August 30, 2002Date of Patent: April 6, 2004Assignee: The Regents of the University of CaliforniaInventor: Trevor C. McMorris
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Patent number: 6696498Abstract: 2-Cyclopenten-1-one and its derivatives comprising the cyclopentenone nucleus as inhibitors of the NF-kB factor, with anti-inflammatory, anti-proliferative-immuno-suppressive, cytoprotective and antiviral activity, the substituents being selected among the ones which do not affect NF-kB inhibitory activity.Type: GrantFiled: May 10, 2002Date of Patent: February 24, 2004Assignee: Consiglio Nazionale Della RichercheInventors: Maria Gabriella Santoro, Antonio Rossi, Giuliano Elia
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Patent number: 6632788Abstract: The compound according to the formula set forth below where A is B is or A and B together form the ring structure and X, R′ and R are independently H and CH3 and m=0 or 1. and the use of the compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products is disclosed.Type: GrantFiled: May 17, 2001Date of Patent: October 14, 2003Assignee: International Flavors & Fragrances Inc.Inventors: Anthony T. Levorse, Jr., Anubhav P.S. Narula, Edward Mark Arruda, Charles E.J. Beck
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Patent number: 6632787Abstract: Carbonyl compounds derived from the reaction of alkyl cyclopentenols and vinyl ethers are described. The carbonyl compounds described have excellent fragrance properties, and their use as fragrances and/or fragrance-enhancing compounds is also described. Processes for the preparation of the carbonyl compounds are described as well.Type: GrantFiled: August 10, 2001Date of Patent: October 14, 2003Assignee: Cognis Deutschland GmbH & Co. KGInventors: Thomas Markert, Ute Lemke, Elke Veit, Theo Ten Pierik, Ralph Nemitz, Volker Porrmann, Marc Speitkamp
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Patent number: 6583322Abstract: This invention describes heretofore unknown forms of dihydro (DHIA) and hexahydro (HHIA) isoalpha acids having a high ratio of trans to cis isomers and a process for their production. Also, non-precipitating clear 5, 10, 20% and higher aqueous solutions thereof, since they are soluble at room temperature in soft water. This is due to the high ratio of trans to cis isomers. Unlike prior art essentially all cis isomer products, they remain haze free both at a neutral pH in water and at 1% to 2% and higher concentrations. This invention has the advantage over the prior art in that DHIA and HHIA can be provided as stable, non-separating liquids, at practical concentrations in the range of 5% to about 40%, which do not require heating to about 50° to 90° C. and above with stirring to effect dissolution of precipitates. The high trans products described herein can be admixed with isoalpha- and tetrahydro-isoalpha acids.Type: GrantFiled: February 25, 2000Date of Patent: June 24, 2003Assignee: Kalamazoo Holdings, Inc.Inventors: Khalil Shahlai, Randall H. Mennett, Paul H. Todd, James A. Guzinski
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Patent number: 6541672Abstract: The invention deals with the derivatives of benzilidine having basic formula as follows (I): wherein X can be cyclohexanone, cyclopentanone, or acetone, while Y and Z can be either electron withdrawing, electron donating or steric group. Y may or may not be the same with Z. Methyl, ethyl, methoxy group or halogen were prefered in the experiment. The benzilidine cyclohexanone, benzilidine cyclopentanone, and benzilidine acetone derivates were found to be novel compounds showing anti-bacterial, antioxidant, and anti-inflammatory activities that enable them to be used for drug.Type: GrantFiled: February 20, 1998Date of Patent: April 1, 2003Assignee: Faculty of Pharmacy, The University of Gadjah MadaInventors: Sardjiman, Mochammad Samhoedi Reksohadiprodjo, Henk Timmerman
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Patent number: 6528688Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: GrantFiled: February 15, 2002Date of Patent: March 4, 2003Assignee: United Therapeutics CorporationInventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
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Publication number: 20030004090Abstract: The compound according to the formula set forth below 1Type: ApplicationFiled: May 17, 2001Publication date: January 2, 2003Inventors: Anthony T. Levorse, Anubahv P.S. Narula, Edward Mark Arruda, Charles E.J. Beck
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Patent number: 6495725Abstract: The present invention provides a simplified and convenient process for the preparation of an optically active enone such as 7,7-dimethyl-6,8-dioxabicyclo-[3,3,0]oct-3-en-2-one. The invention further provides novel optically active intermediate compounds.Type: GrantFiled: December 15, 2000Date of Patent: December 17, 2002Assignee: Chisso CorporationInventor: Kunio Ogasawara
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Patent number: 6465664Abstract: One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, the transition metal catalyst consists essentially of copper and an asymmetric bidentate bisphosphine ligand.Type: GrantFiled: September 13, 2000Date of Patent: October 15, 2002Assignee: Massachusetts Institute of TechnologyInventors: Stephen L Buchwald, Daniel H. Appella, Yasunori Moritani, Ryo Shintani, Valdas Jurkauskas
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Publication number: 20020137800Abstract: 2-Cyclopenten-1-one and its derivatives comprising the cyclopentenone nucleus as inhibitors of the NF-kB factor, with anti-inflammatory, anti-proliferative, immunosuppressive, cytoprotective and antiviral activity, the substituents being selected among the ones which do not affect the NF-kB inhibitory activity.Type: ApplicationFiled: May 10, 2002Publication date: September 26, 2002Applicant: Consiglio Nazionale Della RichereInventors: Maria Gabriella Santoro, Antonio Rossi, Giuliano Elia
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Publication number: 20020133009Abstract: The present invention relates to a method for opening potassium channels in mammalian cells by administering to a mammal effective amounts of potassium channel-opening keto compounds as described herein.Type: ApplicationFiled: March 4, 2002Publication date: September 19, 2002Inventors: George N. Lambrou, Anna Ottlecz, Christine Percicot, Michael Wiederholt
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Patent number: 6441245Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: GrantFiled: April 3, 2000Date of Patent: August 27, 2002Assignee: United Therapeutics CorporationInventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
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Patent number: 6392100Abstract: 2-Cyclopenten-1-one and its derivatives comprising the cyclopentenone nucleus as inhibitors of the NF-kB factor, with anti-inflammatory, anti-proliferative, immunosuppressive, cytoprotective and antiviral activity, the substituents being selected among the ones which do not affect the NF-kB inhibitory activity. Further the cyclopentenone derivative is a cyclopentenone compound which does not have two adjacent aliphatic side chains or a prostaglandin.Type: GrantFiled: June 10, 1999Date of Patent: May 21, 2002Assignee: Consiglio Nazionale Delle RichercheInventors: Maria Gabriella Santoro, Antonio Rossi, Giuliano Elia
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Patent number: 6380262Abstract: 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR1, Y is ═O and Z is H, and when it is a cyclopentane ring, X is ═O, Y is OR2 and Z is OR3, (wherein R1 is R4 or —(CO)—R5; R2 is H, —R6 or —(CO)—R7; and R3 is H, R8 or (CO)—R9 (wherein R4, R5, R6, R7, R8 and R9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R5, R7 and R9 may be each H), provided that the case where R2═R3═H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.Type: GrantFiled: February 6, 2001Date of Patent: April 30, 2002Assignee: Takara Shuzo Co., Ltd.Inventors: Eiji Kobayashi, Hiromu Ohnogi, Nobuto Koyama, Katsushige Ikai, Hiroaki Sagawa, Ikunoshin Kato
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Patent number: 6359181Abstract: The present invention provides a novel compound represented by the general formula I; wherein R is H or COR3; R1 is H, R2, phenyl, or COR3, wherein R2 is C1-C5 lower alkyl and R3 is R2 or phenyl; Z is CH2 or O; Y is OH, OCOR3 or ═O; x is 0 or 1; and X is C1-C5 n-alkyl, C3-C7 cycloalkyl, phenyl, furanyl, thienyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR42, CO2R4 and OR4 wherein R4 is hydrogen or C1-C5 alkyl and dotted lines represent the presence or absence of a double bond and wavy lines represent a cis or trans bond. These novel compounds are especially useful for treating elevated intraocular pressure (ocular hypertension) and glaucoma.Type: GrantFiled: July 26, 2001Date of Patent: March 19, 2002Assignee: Allergan Sales, Inc.Inventors: Robert M. Burk, Mark Holoboski, Mari F. Posner
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Patent number: 6350917Abstract: Crystals of trans-4,5-dihydroxy-2-cyclopenten-1-one of an &agr;-type.Type: GrantFiled: December 29, 1999Date of Patent: February 26, 2002Assignee: Takara Shuzo Co., Ltd.Inventors: Makoto Moriguchi, Katsushige Ikai, Masao Funakoshi, Hiroshi Kobori, Kazuyori Ochiai, Ikunoshin Kato
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Patent number: 6326369Abstract: A compound of the formula: wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the principal chain is 1 to 15; Y represents an acyl, or a hydroxy, an amino or an aromatic group, each of which may be substituted; and ring A represents a 5- to 8-membered ring which may be further substituted apart from —X—Y, or a salt thereof is useful as a pharmaceutical composition for preventing or treating disease related to mitochondrial dysfunction.Type: GrantFiled: July 6, 1999Date of Patent: December 4, 2001Assignee: Takeda Chemicals Industries, Ltd.Inventors: Kaneyoshi Kato, Taiichi Ohra, Masaomi Miyamoto
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Patent number: 6326405Abstract: An anticancer agent in which 4-cyclopentene-1,3-dione represented by the following formula [I] and/or 4-hydroxy-2-cyclopentenone represented by the following formula [II] are/is effective component(s).Type: GrantFiled: November 18, 1999Date of Patent: December 4, 2001Assignee: Takara Shuzo Co., Ltd.Inventors: Eiji Kobayashi, Nobuto Koyama, Ikunoshin Kato
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Patent number: 6287829Abstract: A process for the selective enzymatic hydroxylation of aldehydes and ketones using chiral anchor-protective groups.Type: GrantFiled: September 17, 1999Date of Patent: September 11, 2001Assignee: DSM Fine Chemical Austria Nfg GmbH & Co KGInventors: Anna Stütz de Raadt, Irene Kopper, Herfried Griengl, Markus Klingler, Gerhart Braunegg
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Patent number: 6271408Abstract: This invention relates to trimethylsilyloxy-cyclopentane derivatives: 3-(1-Acetoxy-1-methylethyl)- 2-formyl-1-methyl-1-trimethylsilyloxy-cyclopentane; 4-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-buten-2-one; 5-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-methyl-penta-1,4-dien-3-ol and alkyl 5-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-methyl-penta-2,4-dienoates.Type: GrantFiled: September 13, 2000Date of Patent: August 7, 2001Assignee: Roche Vitamins Inc.Inventors: Hanspeter Pfander, Bruno Traber
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Patent number: 6229051Abstract: The preparation of carbonyl compounds by oxidizing a nitro functional group of an organic compound is described. Oxidation is accomplished under catalyzed oxidative Nef reaction conditions.Type: GrantFiled: June 2, 1998Date of Patent: May 8, 2001Assignee: Eastman Chemical CompanyInventor: Louise O. Sandefur
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Patent number: 6198004Abstract: The invention relates to a process for converting alpha acid and isoalpha acids to tetrahydroisoalpha acid. The process comprises isomerizing an alpha acid to produce isoalpha acid and hydrogenating the isoalpha acid in the presence of a noble metal catalyst wherein, the noble metal catalyst is added incrementally or continuously throughout the hydrogenation step. The invention also relates to tetrahydroisoalpha acids made by the above process.Type: GrantFiled: June 10, 1999Date of Patent: March 6, 2001Assignee: Haas Hop Products, Inc.Inventors: John Paul Maye, Jianping Xu, George Gauthier, Scott W. Weis
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Patent number: 6184419Abstract: The present invention relates to new &agr;,&bgr;-unsaturated ketones of formula I. The new compounds exhibit an intense, very long lasting green galbanum-type odor with fruity undertones. Compositions containing these novel compounds are also provided.Type: GrantFiled: May 10, 2000Date of Patent: February 6, 2001Assignee: Givaudan Roure (International) SAInventors: Katja Berg-Schultz, Jerzy A. Bajgrowiecz
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Patent number: 6166091Abstract: 2,3,4-trihydroxycyclopentanone represented by the following formula [I], its optically active substance or salt thereof.Type: GrantFiled: September 29, 1999Date of Patent: December 26, 2000Assignee: Takara Shuzo Co., Ltd.Inventors: Kaoru Kojima, Katsushige Ikai, Tatsuji Enoki, Nobuto Koyama, Ikunoshin Kato
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Patent number: 6160184Abstract: The present invention provides a method of synthesizing compounds of ##STR1## wherein R and R' are independently (C.sub.1 -C.sub.4)alkyl.Type: GrantFiled: January 6, 2000Date of Patent: December 12, 2000Assignee: The Regents of the University of CaliforniaInventor: Trevor C. McMorris
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Patent number: 6150374Abstract: The invention relates to novel substituted cycloalkenes of the formula (I), ##STR1## to a plurality of processes for their preparation, and to novel intermediates and a plurality of processes for their preparation.Type: GrantFiled: September 29, 1997Date of Patent: November 21, 2000Assignee: Bayer AktiengesellschaftInventors: Herbert Gayer, Peter Gerdes, Ralf Tiemann, Stefan Dutzmann, Klaus Stenzel
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Patent number: 6114300Abstract: Spirocyclic compounds of the general formula (I) are provided which are powerful odorants. Compositions which include these compounds are also provided. They can be used, for instance, in perfumery.Type: GrantFiled: October 29, 1998Date of Patent: September 5, 2000Assignee: Givaudan Roure (International) SAInventors: Bernadette Bourdin, Georg Frater, Jerzy A. Bajgrowicz
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Patent number: 6110969Abstract: A .omega.-cycloalkyl-prostaglandin E.sub.2 derivatives of the formula (I) ##STR1## wherein R is carboxy or hydroxymethyl; R.sup.1 is oxo, methylene or halogen atom; R.sup.2 is H, OH or C1-4 alkoxy; R.sup.3 is H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl substituted by 1-3 of substituent selected from halogen atom, C1-4 alkoxy, C3-7 cycloalkyl, phenyl, or phenyl substituted by 1-3 of substituent selected from halogen atom, C1-4 alkyl, C1-4 alkoxy, nitro, trifluoromethyl; n is 0-4; and non-toxic salt thereof, prodrug thereof and cyclodextrin clathrate thereof can strongly bind on EP.sub.2 subtype receptor. Therefore, they are useful for prevention and/or treatment of immune disease (autoimmune disease, organ transplantation, etc.), asthma, abnormal bone formation, neuron cell death, liver damage, abortion, premature birth or retina neuropathy of glaucoma etc.Type: GrantFiled: February 4, 1998Date of Patent: August 29, 2000Assignee: Ono Pharmaceutical Co. Ltd.Inventors: Kousuke Tani, Shuichi Ohuchida
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Patent number: 6111145Abstract: A cyclopentenone derivative represented by the following formula [I] or an optically active substance or a salt thereof. ##STR1## (In the formula, R.sub.1 and R.sub.2 are same or different and each of them is straight or branched alkyl group, straight or branched alkenyl group, aromatic group, aromatic-aliphatic group or H with a proviso that the case where R.sub.1 =R.sub.2 =H, or R.sub.1 =benzyl group and R.sub.2 =H is excluded.Type: GrantFiled: October 15, 1999Date of Patent: August 29, 2000Assignee: Takara Shuzo CompanyInventors: Eiji Kobayashi, Nobuto Koyama, Ikunoshin Kato, Kaoru Inami, Tetsuo Shiba
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Patent number: 6087401Abstract: There is disclosed a method of manufacturing 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [1] which is characterized in that at least one substance selected from the following (a), (b) and (c) is heated.(a): uronic acid or uronic acid derivative(s);(b): a saccharide compound which contains uronic acid and/or uronic acid derivative(s); and(c): a substance containing a saccharide compound which contains uronic acid and/or uronic acid derivative(s).Type: GrantFiled: February 2, 1999Date of Patent: July 11, 2000Assignee: Takara Shuzo Co., Ltd.Inventors: Nobuto Koyama, Hiroaki Sagawa, Eiji Kobayashi, Tatsuji Enoki, Hua-Kang Wu, Eiji Nishiyama, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6040475Abstract: This invention is concerned with the synthesis of 3-(1-acetoxy-1-methylethyl)-6-oxo-heptanal; 3-(1-acetoxy-1-methylethyl)-2-formyl-1-methyl-cyclopentanol; 5-[2-hydroxy-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclopentyl]-3-methyl- penta-2,4-dien-1-ol and 2,7,11-trimethyl-13-[2-hydroxy-5-(1-hydroxy-1-methylethyl)-2-methyl-cyclop entyl]-trideca-2,4,6,8,10,12-hexaenal which are useful as intermediates for the synthesis of lycopene metabolites.Type: GrantFiled: May 12, 1999Date of Patent: March 21, 2000Assignee: Roche Vitamins Inc.Inventors: Hanspeter Pfander, Bruno Traber
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Patent number: 6025518Abstract: A substituted cyclopentene derivative of formula (V): whereinX.sup.1 is (.alpha.-OZ.sup.a, .beta.-H) or (.alpha.-H, .beta.-OZ.sup.a), X.sup.3 is (.alpha.-OZ.sup.d, .beta.-H), (.alpha.-H, .beta.-OZ.sup.d), or oxygen atom, each of Z.sup.a and Z.sup.d, which may be the same or different, is a hydrogen atom or a protective radical for a hydroxyl radical;U is a radical selected from the group consisting of CR.sup.1 HCH.sub.2, CR.sup.1 .dbd.CH and C.tbd.C,whereinR.sup.1 is a hydrogen atom, halogen atom, substituted silyl radical represented by SiR.sup.9 R.sup.10 R.sup.11 or substituted stannyl radical represented by SnR.sup.14 R.sup.15 R .sup.16,m is an integer of 0 to 6;X.sup.2 is CH.dbd.CH or C.tbd.C,p is an integer of 0 or 1, each of n and q is an integer of 0 to 5; andZ.sup.1 is a hydrogen atom, COOR.sup.y, CN, OH, OCOR.sup.2, CONR.sup.b R.sup.c or NR.sup.d R.sup.e.Type: GrantFiled: September 8, 1998Date of Patent: February 15, 2000Assignees: Nissan Chemical Industries, Ltd., Fumie SATOInventor: Fumie Sato