Abstract: 15-HETE derivatives with enhanced metabolic stability and methods of their use for treating dry eye are disclosed.

Abstract: Provided is a novel mercaptomethylphenyl group-containing diorganopolysiloxane compound represented by the following Formula (1): wherein R1 represents methyl or phenyl; R2 represents a linear or branched alkyl group having 1 to 6 carbon atoms, a phenyl group or A; l represents an integer of 0 to 500; m represents an integer of 0 to 1,000; n represents an integer of 0 to 500; p represents an integer of 0 to 2; and A is a group represented by Formula (2): wherein X represents a linear or branched alkylene group having 2 to 20 carbon atoms; at least one of R3, R4, R5, R6 and R7 represents mercaptomethyl, and the remaining groups each represent a hydrogen atom or a linear or branched alkyl group having 1 to 20 carbon atoms.

Abstract: Radiation-curable compositions, having high elongation at break and toughness after cure can include the following pre-mixture components: a) a polymer, oligomer or monomer having at least one (meth)acrylate functional group; b) an oligomer or monomer, exclusive of (meth)acrylate functional groups, having an ethylenically unsaturated functional group; and c) an elongation promoter; wherein the composition, after radiation-cure, has an elongation at break of at least about 200%. Glass substrates and optical fibers are coated with the radiation-curable composition. Monofilament fiber or a plurality of fiber filaments, such as sewing thread, are coated with the radiation-curable binder composition, which after cure, demonstrates high elongation at break.

Abstract: Presulfurizing process and presulfurization promoter for a desulfurization catalyst to be used in a hydrodesulfurization unit of petroleum refinery of high molecular hydrocarbons, in which fresh metal oxide in said desulfurization catalyst is sulfurized with hydrogen sulfide produced from sulfur-containing compounds in a feed stream. In the invention, a compound having mercapto alkylthio group: HS—CmH2m—S— (in which “m” is an integer of 2 to 4) is added as promoter at a proportion of 10 ppm to 0.5% by weight and presulfurization is promoted at 180 to 260° C.

Abstract: The invention relates to a polymeric film composed of an optically anisotropic material made from a cross-linked synthetic resin composition comprising a polymer network, being obtainable by copolymerization of a mixture comprising (a) at least one monomer or oligomer, each of said monomers or oligomers having at least two polymerizable functional groups selected from the group consisting of (meth-)acrylate ester, epoxy and vinyl ether, (b) at least one achiral liquid crystalline monomer or oligomer, each of said monomersloligomers having mesogenic groups and one polymerizable functional group selected from the group consisting of (meth-)acrylate ester, epoxy and vinyl ether.

Abstract: A highly efficient method of producing alkyl mercaptan and/or dialkyl monosulfides which involves employing carbon dioxide as an internal coolant is described. Only negligible amounts of carbonyl sulfide were formed. In addition, relatively easy separation of carbon dioxide from the reaction mixture facilitates an efficient coolant recycle process, giving a simple and effective mode of temperature control.

Abstract: An electroptical system which between 2 electrode layers contains a PDLC film comprising a liquid crystal mixture forming micro-droplets in an optically isotropic, transparent polymer matrix, in which one of the refractive indices of the liquid crystal mixture is matched to the refractive index of the polymer matrix, which exhibits an electrically switchable transparency essentially independent of the polarization of the incident light, the precursor of the PDLC film of which comprises one or more monomers, oligomers and/or prepolymers and a photoinitiator, and is cured photoradically, the liquid crystal mixture of which comprises one or more compounds of the formula I in which the substituents are defined herein characterized in that the liquid crystal mixture additionally contains one or more reactive liquid crystalline compounds in order to obtain improved switching times especially at low temperatures.

Abstract: Disclosed is a method of making a mercaptan by reacting hydrogen sulfide with an olefin in the presence of a heterogeneous acidic catalyst. The catalyst can be made by calcining a mixture of a hydroxide, such as Zr(OH).sub.4 or Ti(OH).sub.4, with an acidic site donor, such as H.sub.2 SO.sub.4, (NH.sub.4).sub.2 SO.sub.4, or WO.sub.3.

Abstract: A method for the preparation of aromatic hydroxythiols including oxidizing an aromatic aminothiol to form an aminodisulfide compound; forming a bis-diazonium salt of the aminodisulfide compound; and reacting the bis-diazonium salt with water to form an aromatic hydroxyldisulfide compound, which is then reduced to the hydroxythiol. New bis-diazonium aromatic disulfide compounds are also disclosed.

Abstract: The present invention provides aromatic amine substituted metal chelating compounds, chelates and chelate-targeting moiety conjugates formed from the chelating compounds, and methods for making and using these compounds. Metals capable of being chelated by the chelating compounds include radionuclides, such as .sup.99m Tc and .sup.186188 Re.

Abstract: The invention provides a complexant compound of formula IR.sup.3 S (CR.sup.1.sub.2).sub.n N(R.sup.2).sub.i (CR.sup.1.sub.2).sub.n X(CR.sup.1.sub.2).sub.n N(R.sup.2).sub.i (CR.sup.1.sub.2).sub.n SR.sup.3(I )(wherein each n, which may be the same or different, is an integer 2, 3 or 4 (preferably 2); each i, which may be the same or different, represents 0 or 1; each R.sup.3, which may be the same or different, is H or a thiol protecting group, preferably a protecting group; X is O, S, N, NR.sup.4 or a substituted phosphorus (eg. oxo substituted phosphorus), preferably S or N; each R.sup.4, which may be the same or different, is hydrogen or an optionally substituted organic group; each R.sup.1, which may be the same or different, is hydrogen or an optionally substituted organic group, or a moiety CR.sup.1.sub.2 may represents a carbonyl group or two, three or four R.sup.

Abstract: Novel substrates of phospholipases, lysophospholipases and lipases are disclosed.

Abstract: A process for the deoxygenation of organic oxo compounds, in particular phosphine oxides to phosphines and nitrobenzene to aniline, with reduced redox catalysts in a non-steady-state reaction with decoupled reductive regeneration of the redox catalyst entails the redox catalyst being reduced to a lower oxidation state and being reused for the deoxygenation.

Abstract: A novel polythiol having four or more functional groups, a process for producing the polythiol comprising reacting thiourea with a specific compound, a sulfur-containing urethane-based resin prepared from the polythiol and a lens made of the resin. The resin has a high refractive index, and low dispersion of refractive index, is lightweight, colorless and transparent, has no optical distortion, and has excellent characteristics in weatherability, dye-affinity, heat resistance, impact resistance and machinability.

Abstract: Mercaptocycloacyl aminoacid inhibitors of endopeptidase of the formula ##STR1## or a pharmaceutically acceptable salt thereof, alone or in combination with an ACE inhibitor or an ANF, in the treatment of cardiovascular disorders such as hypertension, congestive heart failure, edema and renal insufficiency, and treatment of nephrotoxicity pain conditions, and pharmaceutical compositions containing said compounds are disclosed.

Abstract: Hydroxyaryl enol ether alkali metal salts having the formula: ##STR1## in which T is a fused, substituted or unsubstituted polycycloalkylidene group, OR.sup.3 is an ether group Y is a light-emitting fluorophore-forming group which will be part of a luminescent substance formed by decomposition of a 1,2-dioxetane subsequently formed from the hydroxyaryl enol ether alkali metal salt, capable of absorbing energy to form an excited state from which it emits optically detectable energy to return to its ground state, and AM.sup.30 is an alkali metal cation, processes for the preparation of these intermediate salts, and their use as starting materials for acylation, phosphorylation and glycosylation reactions to give intermediates reactable to give stable, water-soluble chemiluminescent 1,2-dioketames, particularly ones that are enzymatically cleavable, are disclosed.

Abstract: Compounds having non-linear optical activity of the general formula ##STR1## wherein D and A are electron donor and acceptor groups, respectively, R.sup.1 and R.sup.2 are aromatic bridging groups, X and Y are preferably groups capable of partaking in polymerization reactions are suitable for use in polymer-based light modulator devices.

Abstract: This invention is addressed to antioxidants which are polymerizable using the Ziegler catalyst system. The antioxidant of the present invention has the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each aryl groups containing a hindered antioxidant structure imparting antioxidant properties to the compounds. The compounds of the present invention are useful in the polymerization of olefin compounds using Ziegler catalyst systems whereby the antioxidant of the invention becomes chemically bound to the polymer while, at the same time, imparting antioxidant properties thereto.

Abstract: This invention is addressed to antioxidants which are polymerizable using the Ziegler catalyst system. The antioxidant of the present invention has the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each aryl groups containing a hindered antioxidant structure imparting antioxidant properties to the compounds. The compounds of the present invention are useful in the polymerization of olefin compounds using Ziegler catalyst systems whereby the antioxidant of the invention becomes chemically bound to the polymer while, at the same time, imparting antioxidant properties thereto.

Abstract: A process for the recovery of minerals from an ore or concentrate containing the same wherein the minerals are recovered in a froth from an aqueous pulp containing the ore or concentrate and wherein one or more mineral flotation agents are employed in the aqueous pulp to control the type of minerals in the froth is provided. The mineral flotation agents used in carrying out the process comprise compounds formed by the addition of hydrogen sulfide to dicyclopentadiene.

Abstract: Compounds of the formula ##STR1## wherein n is either 0 or 1; R.sup.1 and R.sup.2 is hydrogen and the other is hydrogen, hydroxy, oxo group, a protected hydroxy or protected oxo group; R.sup.3 is hydroxy oxo group, .dbd.CH--CH.sub.2 --OH, .dbd.CH--CHO or one of the foregoing groups where the hydroxy or oxo functions are protected; R.sup.4 is --CO--OR.sup.6, --CO--R.sup.6, --CO--NR.sup.6 R.sup.7, --CO--Cl or --SO.sub.2 --R.sup.6 ; R.sup.6 is saturated or aromatic hydrocarbon; and R.sup.7 is saturated or aromatic hydrocarbon or hydrogen,are converted by cleavage of R.sup.4 OH into corresponding cycloalkenes and protecting groups, if present, are hydrolyzed.The compounds obtained are valuable intermediates in carotenoid syntheses.

Abstract: A process for making alkyl mercaptans in high yield while minimizing the formation of dialkyl sulfides is conducted by reacting an olefin with hydrogen sulfide in an inert solvent (e.g. CH.sub.2 Cl.sub.2) containing a Lewis Acid catalyst (e.g. BF.sub.3). Best results are obtained when the olefin is added to the hydrogen sulfide solution at a rate that keeps the amount of unreacted olefin below about 0.05 moles per mole of hydrogen sulfide.

Abstract: Sulfur containing terpenes of formula ##STR1## both in its racemic and enantiomeric forms possess useful organoleptic properties in developing especially fruity notes, more particularly of grapefruit character.(S)-(-)-1-p-menthene-8-thiol and (R)-(+)-1-p-menthene-8-thiol are new compositions of matter.

Abstract: The invention relates to polyethers having an an average molecule weight of 3000 to 5000 and having a propylene oxide proportion of 60 to 80% and an ethylene oxide proportion of 20 to 40%. Also included in the invention are compositions containing said polyethers and methods for the use of said polyethers and compositions, particularly for their anti-lipidaemic effect.

Abstract: A process is provided for preparing alkyl mercaptans by reacting a dialkyl sulfide with hydrogen sulfide in the presence of a zeolite catalyst.

Abstract: The invention provides phenol ethers of the formula: ##STR1## wherein R is branched C.sub.3-4 alkyl, C.sub.3-4 cycloalkyl, branched cyano(C.sub.3-4 alkyl), phenyl(C.sub.2-3 alkyl), halophenyl(C.sub.2-3 alkyl), (C.sub.1-4 alkoxy)phenyl(C.sub.2-4 alkyl), or (C.sub.1-4 acyl)amino(C.sub.1-4 alkyl),alk is C.sub.1-4 alkyl substituted by a 3 to 6 membered cycloalkyl group,X is --O--, --S-- or --SO.sub.2 --; andR.sub.1 is --C.sub.1-4 alkyl- or --C.sub.1-4 alkoxy-,in their racemic and optically active forms, and their addition salts with pharmaceutically acceptable acids. These compounds are useful in therapy as .beta.-adrenergic blocking agents. Intermediates are also provided.