Polycyclo Ring System Patents (Class 568/665)
-
Patent number: 7232795Abstract: The present invention is directed to novel substituted cyclopropane ethers compounds of the general formulae selected from the group consisting of R and R1 independently represent a hydrogen or a straight, branched, or cyclic hydrocarbon moiety consisting of less then 15 carbon atoms and containing single and/or double bonds.Type: GrantFiled: November 23, 2005Date of Patent: June 19, 2007Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Franc T. Schiet
-
Patent number: 7109383Abstract: The invention relates to a fluorine-containing allyl ether compound represented by the formula 1, wherein R represents an organic group containing at least one fluorine atom and an alicyclic structure. The invention further relates to a fluorine-containing copolymer containing a first unit derived from the fluorine-containing allyl ether represented by the formula 1; and a second unit derived from a vinyl monomer.Type: GrantFiled: September 26, 2003Date of Patent: September 19, 2006Assignee: Central Glass Company, LimitedInventors: Satoru Kobayashi, Katsunori Kawamura, Kazuhiro Yamanaka, Haruhiko Komoriya, Kazuhiko Maeda
-
Patent number: 7033728Abstract: The present invention relates to a photosensitive composition useful at wavelengths between 300 nm and 10 nm which comprises a polymer containing a substituted or unsubstituted higher adamantane.Type: GrantFiled: December 29, 2003Date of Patent: April 25, 2006Assignee: AZ Electronic Materials USA Corp.Inventor: Ralph R. Dammel
-
Patent number: 6943272Abstract: The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present —CHCH3OH or —CHCH3OCOR or —CHCH3XCH2CHOHR? or —CHCH3OCHR?CH2OH or formula (II) when the dotted line bond is absent —CHCH3OH or —CHCH3OCOR or —COCH3 or formula (II) or —CHCH3XCH2CHOHR? or —CH2CH2XCH2CHOHR? or —CHCH3OCHR?CH2OH or —CHCHCOR? or —CH2CH2CHR?OH or —CH2CH2CHR?OCOR or CHCHCHOHR? or —CHCHCHR?OCOR, wherein R represents H, Me, Et, Pr, isoPr, But, isoBut, CH3CH2)4, (CH3)2CHCH2, CH2CH, (CH3)2CCH, and R? represents H, Me or Et, and X represents O, N or S, and their preparation method. Because of their fragrance, said compounds are highly interesting for the perfume industry, for cosmetic and care products.Type: GrantFiled: October 23, 2002Date of Patent: September 13, 2005Assignee: V. Mane FilsInventors: Jean Mane, Jean-Jacques Chanot, Fabrice Le Borgne, Martin Schroeder
-
Patent number: 6939845Abstract: The present invention provides a fragrance precursor of formula I: that is capable of forming a fragrant ketone of formula II: and a fragrant lactone of formula III:Type: GrantFiled: June 18, 2001Date of Patent: September 6, 2005Assignee: Givaudan SAInventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
-
Patent number: 6930128Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.Type: GrantFiled: July 10, 2003Date of Patent: August 16, 2005Assignee: The Children's Medical Center CorporationInventors: Robert John D'Amato, Moses Judah Folkman
-
Publication number: 20040131648Abstract: Novel and nonobvious compounds that function, alone or in combination, as nuclear hormone receptors for the stimulation and/or improvement of murine, mammalian skin. Specifically, beta-ionol analog and fatty acid analog compounds that are believed to function as RXR, RAR and/or PPAR receptor ligands to encourage skin differentiation and discourage excess skin proliferation. The present invention further relates to one or more products, consumer and otherwise, comprising the novel, nuclear hormone receptor ligands disclosed herein.Type: ApplicationFiled: October 24, 2002Publication date: July 8, 2004Applicant: The Procter & Gamble CompanyInventors: Mitchell Anthony deLong, Scott Louis Cohen
-
Patent number: 6734159Abstract: Cyclic isolongifolenyl ethers of the general formula A, where wavy lines mean &agr;- and &bgr;-configuration, and R is the following radicals. R=Me, Et, Pr, iso-Pr, Bu, sec-Bu, iso-Bu, tert-Bu. These isolongifolenyl ethers are excellent fragrances and can, in particular, be used as a constituent of fragrance mixtures or perfume oil for the perfuming of cosmetic or technical consumer goods. Also described are processes for the preparation of said cyclic isolongifolenyl ethers.Type: GrantFiled: March 25, 2003Date of Patent: May 11, 2004Assignee: Symrise GmbH & Co. KGInventors: Wilhelm Pickenhagen, Dietmar Schatkowski
-
Publication number: 20040082724Abstract: In accordance with the present invention, there are provided novel heterobifunctional monomers and users for the same. Invention compounds have many of the properties required by the microelectronics industry, such as, for example, hydrophobicity, high Tg values, low dielectric constant, ionic purity, low coefficient of thermal expansion (CTE), and the like. These properties result in a thermoset that is particularly well suited to high performance applications where typical operating temperatures are often significantly higher than those at which prior art materials were suitable. Invention compounds are particularly ideal for use in the manufacture of electronic components, such as, for example, printed circuit boards, and the like.Type: ApplicationFiled: July 1, 2003Publication date: April 29, 2004Applicant: Henkel Loctite CorporationInventors: Stephen M. Dershem, Kevin J. Forrestal, Puwei Liu
-
Patent number: 6720463Abstract: The present invention provides a process for producing an alkanediol derivative represented by the general formula (II) from an ester compound represented by the general formula (I), safely without giving rise to racemization. The present invention lies in a process for producing an alcohol derivative represented by the following general formula (II): (wherein R2 and R3 are each independently a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; X is a hydrogen atom or a protecting group for hydroxyl group; and n is 0 or 1), which process comprises reducing an ester compound represented by the following general formula (I): (wherein R1 is an alkyl group having 1 to 4 carbon atoms; and R2, R3, X and n have the same definitions as given above) with sodium borohydride in a mixed solvent of at least one kind of solvent selected from the group consisting of aromatic hydrocarbons, aliphatic hydrocarbons and alicyclic hydrocarbons and a primary alcohol.Type: GrantFiled: July 13, 2001Date of Patent: April 13, 2004Assignee: Ihara Chemical Industry Co., Ltd.Inventors: Yoshikazu Kimura, Yukio Uchida, Shuichi Fujimoto
-
Publication number: 20030166974Abstract: Cyclic isolongifolenyl ethers of the general formula A, where wavy lines mean &agr;- and &bgr;-configuration, and R is the following radicals.Type: ApplicationFiled: March 25, 2003Publication date: September 4, 2003Applicant: Examiner Rosalynd Keys in GroupInventors: Wilhelm Pickenhagen, Dietmar Schatkowski
-
Patent number: 6610705Abstract: The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome, Pharmaceutical compositions comprising said novel methane derivatives, process for the preparation of the novel methane derivatives and methods for the treatment of esterogen related diseases or syndrome.Type: GrantFiled: March 31, 2000Date of Patent: August 26, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Neeta Srivastava, Arvinder Grover
-
Patent number: 6593363Abstract: The present invention relates to diterpene derivatives prepared from the components which are extracted from Acanthopanax Koreanum and represented by Chemical Formula (1).Type: GrantFiled: September 15, 2000Date of Patent: July 15, 2003Assignees: Sae Han Pharm. Co., Ltd.Inventors: Young Ger Suh, Young Hoon Choi, Hye Kyung Lee, Young Ho Kim, Hyoung Sup Park
-
Patent number: 6548715Abstract: A compound of the formula I: in which P is hydrogen or alkyl; Y and Y′ are each hydrogen or, when taken together, represent a group ═CH2; W and W′ are each hydrogen; X is selected from the group consisting of a hydroxyalkyl, a hydroxyalkoxy, an alkoxy optionally comprising an epoxide function, a hydroxyalkene, a hydroxyalkadiene, a hydroxyalkyne and isomeric forms thereof; and a) either R1 and R3 or R′3 form a saturated 5- or 6-membered carbocyclic ring and R2, R′2, R3 or R′3, R4, R′4, R5 and R′5 are each independently hydrogen or alkyl; or b) R2 or R′2 and R4 or R′4 form a saturated 5- or 6-membered carbocyclic ring, and R1, R2 or R′2, R3, R′3, R4 or R′4, R5 and R′5 are each independently hydrogen or alkyl; or c) R3 or R′3 and R5 or R′5 form a saturated or unsaturated 5- or 6-membered carbocyclic ring, and R1, R2, R′2, R3 or R′3, R4, R′4, and R5 or R′5 are each indepType: GrantFiled: October 28, 1999Date of Patent: April 15, 2003Assignee: Laboratoire Theramex S.A.Inventors: Roger Bouillon, Maurits Vandewalle, Pierre Jean De Clercq
-
Publication number: 20020173668Abstract: Diels-Alder adducts of dienophiles such as epoxybutene with dienes such as cyclopentadiene and cyclohexadiene are produced by carrying out the Diels-Alder reaction thereof at an elevated pressure. Addional dienophiles disclosed include 2,5-dihydrofuran and derivatives thereof; Additional dienes include isoprene and butadiene. Compounds produced from such reactions are also disclosed.Type: ApplicationFiled: February 8, 2002Publication date: November 21, 2002Inventors: Mark E. Welker, Marion A. Franks
-
Patent number: 6451380Abstract: Compounds useful as reactive coalescents and methods of improving the stability of reactive coalescents are disclosed. A process for the preparation of low molecular weight polymers which are also useful as reactive coalescents is also disclosed.Type: GrantFiled: March 25, 1998Date of Patent: September 17, 2002Inventors: David Gerald Speece, Jr., William David Weir, Eric Karl Eisenhart, Michael Damian Bowe, Martha Alice Harbaugh Wolfersberger
-
Patent number: 6444858Abstract: The present invention provides a method for alkoxylating organic compounds comprising contacting an organic compound adapted to be alkoxylated with an alkylene oxide in a reaction vessel under conditions effective to alkoxylate the organic compound. The alkylene oxide is maintained in vapor form during transport to said reaction vessel, during discharge into said reaction vessel, and during contacting of the organic compound with the alkylene oxide. The result is an alkoxylated product containing less flocculant.Type: GrantFiled: April 19, 1999Date of Patent: September 3, 2002Assignee: Baker Hughes IncorporatedInventor: Philip Leung
-
Patent number: 6414167Abstract: The invention relates to a novel octafluorotricyclodecane derivative represented by the general formula (1), where R1 is a hydrogen atom, a halogen atom, a hydrocarbon group or a halogenated hydrocarbon group, m is 0 or 1, and R2 is represented by the general formula (2), where R3 is a hydrogen atom or a hydrocarbon group optionally having a substituent. This octafluorotricyclodecane derivative may be useful as a monomer for producing various functional polymers or as a raw material of the same.Type: GrantFiled: June 19, 2001Date of Patent: July 2, 2002Assignee: Central Glass Company, LimitedInventors: Satoru Miyazawa, Michitaka Ootani, Kentaro Tsutsumi
-
Publication number: 20020052530Abstract: Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or antiinflammatory activity are described, wherein in formulae 5 and 9, R1 and R3 to R15, and in formula 6, R1, R2 and R4 to R15, are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oximc, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing one or more heteroatoms selected from N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 caType: ApplicationFiled: June 8, 1998Publication date: May 2, 2002Inventors: JOHN WALSH, NEIL FRANKISH, HELEN SHERIDAN, WILLIAM BYRNE
-
Patent number: 6365771Abstract: Decane compound or decene compound shown in the formula [1] below wherein A1 and A2 are independently hydrogen or (meth)acryloyl group or 2-vinyloxyethyl group; and the dotted line is single bond or double bond with the proviso that A1 and A2 are not hydrogen at the same time; and curable resin composition containing said compound therein. The compound are suitable as the photo-monomer for resist raw materials because of high clarity at short wavelength ultraviolet light, dry etching resistance, adhesive property for the substrate and high solubility in alkaline developing solution in addition to high sensitivity and greater resolution; as the monomer for optic raw materials and disk overcoat materials because of high clarity, low birefringence and low water absorption rate; and as the monomer for the coating raw materials such as EB curable coating raw materials because of high reactivity, high wear characteristics and water resistance.Type: GrantFiled: March 14, 2001Date of Patent: April 2, 2002Assignee: Nissan Chemical Industries, Ltd.Inventors: Hideo Suzuki, Takayasu Nihira, Shinichiro Takigawa
-
Patent number: 6344590Abstract: An adamantanemethanol derivative of the invention is represented by the following formula (1), wherein Ra is a hydrogen atom or a hydrocarbon group; Rb is a hydrocarbon group having a carbon atom, to which carbon atom at least one hydrogen atom is bonded, at a bonding site with the adjacent carbon atom; Rc, Rd and Re are each a hydrogen atom, a hydroxyl group which may be protected by a protective group or the like; provided that a hydroxyl group protected by a protective group or the like is bonded to at least one carbon atom constituting the adamantane skeleton when Ra is a hydrogen atom or a methyl group and Rb is a methyl group; and at least one substituent, in addition to the HO—C(Ra)(Rb)— group indicated in the formula (1), is bonded to the adamantane ring when one of Ra and Rb is a methyl group and the other is an ethyl group.Type: GrantFiled: December 21, 1999Date of Patent: February 5, 2002Assignee: Daicel Chemical Industries, Ltd.Inventors: Tatsuya Nakano, Hiroshi Shimojitosyo
-
Patent number: 6235926Abstract: The present invention relates to perfumery of compounds of the general formula in which R1 and R2 are identical or different and represent each a methyl or ethyl group, R3 represents hydrogen or an alkyl group from C1 to C4, linear or branched, and R4 represents hydrogen, an alkyl group from C1 to C4, linear or branched, or an acyl group of formula R5C(O)—, R5 being hydrogen or an alkyl group from C1 to C4, linear or branched. The novel odoriferous character of these compounds is the combination of woody with fruity notes.Type: GrantFiled: September 16, 1999Date of Patent: May 22, 2001Assignee: Firmenich SAInventors: Karl-Heinrich Schulte-Elte, Hervé Pamingle, Christian Vial
-
Patent number: 5905074Abstract: A compound of the formula ##STR1## useful for treating vitamin D dependent disorders.Type: GrantFiled: December 18, 1997Date of Patent: May 18, 1999Assignee: Hoffmann-La Roche Inc.Inventor: Fernand Schneider
-
Patent number: 5733866Abstract: Described are methyl substituted hexahydroindanols and alkyl ethers thereof defined according to the generic structure: ##STR1## wherein R.sub.7 represents hydrogen or C.sub.1 -C.sub.3 alkyl; wherein R.sub.1 represents methyl or ethyl; wherein R.sub.4 represents methyl or hydrogen; and wherein R.sub.2, R.sub.3, R.sub.5 and R.sub.6 each represents methyl or ethyl with the provisos that:(1) at least three of R.sub.2, R.sub.3, R.sub.5 and R.sub.6 represent methyl; and(2) when each of R.sub.2, R.sub.3, R.sub.5 and R.sub.6 is methyl, then R.sub.4 is methyland uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles including but not limited to perfumed polymers, solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles, cosmetic powders and hair preparations.Type: GrantFiled: August 22, 1996Date of Patent: March 31, 1998Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, James Joseph Koestler, Marie R. Hanna, Honorine Hattab, Francis Charles Antoine Thibaudeau, Charles E. J. Beck
-
Patent number: 5693606Abstract: The described compounds of the general formula A, in which the wavy lines mean .alpha. and .beta. configuration and R.sub.1 and R.sub.2 mean hydrogen, methyl or ethyl groups ##STR1## are new and useful as odorants or components or mixtures of odorants or perfume oils. Their production in a method known per se, involves oxidation of isolongifolene obtained from longifolene to isolongifolane, which is then equilibrated with base extraction and/or reduced to isolongifolan-3-ol and this is then reacted with a symmetric acetal of the formula R.sub.2 --OCHR.sub.1 --O--R.sub.2, in which R.sub.1 is hydrogen or methyl and R.sub.2 is methyl, ethyl or propyl.Type: GrantFiled: February 22, 1995Date of Patent: December 2, 1997Assignee: DRAGOCO Gerberding & Co. AGInventors: Ernst Joachim Brunke, Dietmar Schatkowski
-
Patent number: 5665698Abstract: Described are methyl substituted tetrahydroindane alkyl enol ethers defined according to the structure: ##STR1## wherein R.sub.1 represents methyl or ethyl; wherein R.sub.4 represents methyl or hydrogen; wherein R.sub.2, R.sub.3, R.sub.5 and R.sub.6 each represents methyl or ethyl with the provisos that:(1) at least three of R.sub.2, R.sub.3, R.sub.5 and R.sub.6 represent methyl; and(2) when each of R.sub.2, R.sub.3, R.sub.5 and R.sub.6 is methyl, then R.sub.4 is methyland uses thereof in augmenting, enhancing or imparting an aroma in or to perfume compositions, colognes and perfumed articles including but not limited to perfumed polymers, solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles, cosmetic powders and hair preparations. Also described are processes for preparing same as well as the process intermediates defined according to the structure: ##STR2## wherein R.sub.7 and R.sub.Type: GrantFiled: September 6, 1996Date of Patent: September 9, 1997Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, James Joseph Koestler, Peter J. Hartong, Marie R. Hanna, Charles E. J. Beck
-
Patent number: 5629454Abstract: Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.Type: GrantFiled: September 23, 1994Date of Patent: May 13, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Victor E. Marquez, Juan B. Rodriguez, Marc C. Nicklaus, Joseph J. Barchi, Jr., Maqbool A. Siddiqui
-
Patent number: 5597932Abstract: The invention is drawn to a compound having the following formula ##STR1## in which X.sup.1 and X.sup.2, which may be the same or different, represent hydrogen or a hydroxy-protecting group, X.sup.4 is hydrogen, A is selected from --COOAlkyl and CH.sub.2 OH, and B is a hydroxy group, or A and B, when taken together, represent an oxo group. These compounds are useful as intermediates in the production of 19-nor vitamin D derivatives.Type: GrantFiled: May 16, 1995Date of Patent: January 28, 1997Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman, Rolf E. Swenson
-
Patent number: 5525745Abstract: The invention describes intermediates for use in the synthesis of 1.alpha.-hydroxy-19-nor-vitamin D compounds. The intermediates have the following formula: ##STR1## The disclosed process includes (a) the construction of a 5,8-diol-6-yne intermediate by joining ring-A and ring-C/D portions of the desired end product via the condensation of an acetylenic derivative containing the C/D-ring portion of the desired end product with a cyclic dihydroxy ketone representing the A-ring of the desired end product; (b) the partial reduction of the 6,7 acetylenic triple bond linkage between the A and C/D ring portions to obtain a 5,8-diol-6-ene intermediate; and (c) the reductive removal of the 5,8-oxygen functions to generate the required 5,7-diene end product from which the desired 7-trans(7E)-isomer is purified directly, or after optional double bond isomerization of the 7-cis(7Z)-isomer employing a novel thiophenol-promoted isomerization step.Type: GrantFiled: March 27, 1995Date of Patent: June 11, 1996Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Fariba Aria
-
Patent number: 5508392Abstract: The present invention relates to methods for the treatment of prevention of osteoporosis by the administration of a vitamin D glycoside or vitamin D orthoester glycoside, or an analog thereof.Type: GrantFiled: April 20, 1994Date of Patent: April 16, 1996Inventor: Michael F. Holick
-
Patent number: 5436401Abstract: A 22-oxacholecalciferol derivative represented by formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group; and R.sub.2 and R.sub.3, which may be the same or different, each represent a lower alkyl group having from 1 to 5 carbon atoms,and a process for preparing the same are disclosed. The compound of the present invention has potent differentiation inducing activity and cell proliferation inhibitory activity and is expected to be useful as an anti-tumor agent, an antirheumatic, a treating agent for psoriasis, and a treating agent for hyperparathyreosis. The process of the present invention makes it possible to efficiently produce a desired 22-oxacholecalciferol derivative while reducing by-production.Type: GrantFiled: June 13, 1994Date of Patent: July 25, 1995Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masahiro Kato, Tetsuhiro Mikami, Kiyoshige Ochi, Hiroyoshi Watanabe, Noboru Kubodera
-
Patent number: 5430196Abstract: A synthesis of 1.alpha.-hydroxy-19-nor-vitamin D compounds comprises (a) the construction of a 5,8-diol-6-yne intermediate by joining ring-A and ring-C/D portions of the desired end product via the condensation of an acetylenic derivative containing the C/D-ring portion of the desired end product with a cyclic dihydroxy ketone representing the A-ring of the desired end product; (b) the partial reduction of the 6,7 acetylenic triple bond linkage between the A and C/D ring potions to obtain a 5,8-diol-6-ene intermediate; and (c) the reductive removal of the 5,8-oxygen functions to generate the required 5,7-diene end product from which the desired 7-trans(7E)-isomer is purified directly, or after optional double bond isomerization of the 7-cis(7Z)-isomer employing a novel thiophenol-promoted isomerization step.Type: GrantFiled: September 8, 1994Date of Patent: July 4, 1995Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Fariba Aria
-
Patent number: 5422365Abstract: A compound selected from those of formula (I): ##STR1## wherein: R.sub.1, R'.sub.1 and R.sub.2 are each selected, independently of the others, from hydrogen and an alkyl radical, the two R.sub.2 groups being in the cis position in relation to the rings,and R, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R'a and R'b are as defined in the description,useful therapeutically in the regulation of the secretion of insulin.Type: GrantFiled: August 12, 1994Date of Patent: June 6, 1995Assignee: Adir et CompagnieInventors: David Billington, Francoise Perron-Sierra, Isabelle Picard, Jacques Duhault, Joseph Espinal
-
Patent number: 5420358Abstract: The process for the preparation of dicyclopentenyloxyethanol having the formula ##STR1## by reaction of dicyclopentadiene with ethyleneglycol in the presence of a catalyst consisting of an acid cation exchange resin, characterized in that it consists in mixing the dicyclopentadiene and the ethyleneglycol in a mixing tank to obtain a mixture, and bringing the mixture in contact with the catalyst in a cartridge separate from the mixing tank.Type: GrantFiled: January 18, 1994Date of Patent: May 30, 1995Assignee: Elf Atochem S.A.Inventors: Alain Riondel, Clement Becker
-
Patent number: 5399587Abstract: The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1## In addition, a novel microbiological process for producing the claimed compounds is described.Type: GrantFiled: December 13, 1993Date of Patent: March 21, 1995Assignee: Merck & Co., Inc.Inventors: Maria L. Garcia, Robert A. Giacobbe, Otto D. Hensens, Gregory J. Kaczorowski, Seok H. Lee, Owen B. McManus, Deborah L. Zink
-
Patent number: 5354901Abstract: Perfluoro(cycloaliphatic methyleneoxyalkylene) compositions are provided. These compositions comprise perfluoro(cycloaliphatic methyleneoxyalkylene) carbonyl fluoride compounds having (a) a perfluorocycloaliphatic moiety which can have up to two perfluoroalkyl substituents and a perfluoroalkylene substituent, and (b) a perfluoromethyleneoxyalkylene carbonyl fluoride radical, the methylene group of the radical being bonded to a ring carbon atom or the perfluoroalkylene substituent of the moiety and the alkylene group of the perfluoromethyleneoxyalkylene carbonyl fluoride being a perfluoro(methyl)methylene group, a perfluoroisopropyleneoxy(methyl)methylene group, or a poly(perfluoroisopropyleneoxy)perfluoro(methyl)methylene group having up to about 10 perfluoroisopropyleneoxy units.Type: GrantFiled: February 1, 1993Date of Patent: October 11, 1994Assignee: Minnesota Mining and Manufacturing CompanyInventors: Richard M. Flynn, Patricia M. Savu
-
Patent number: 5321007Abstract: Described are 2,6-dimethylbicyclo[3.3.1]non-6-ene-3-methanol and substituted derivatives thereof defined according to the generic structure: ##STR1## wherein each of the dashed lines represents a carbon-oxygen covalent bond or no bond; N is 0 or 1; R.sub.1 represents hydrogen, C.sub.1 -C.sub.2 lower alkyl, lower alkenyl, lower alkylenyl, C.sub.1 -C.sub.2 acyl, alkoxycarbonyl, magnesium halo or lithium; and R.sub.2 represents methyl or hydrogen as well as uses thereof (wherein R.sub.1 is not magnesium halo or lithium) for augmenting or enhancing the aroma of consumable materials selected from the group consisting of perfume compositions, perfumed articles, colognes, deodorizing articles, deodorizing compositions and malodor maskants.Type: GrantFiled: October 27, 1993Date of Patent: June 14, 1994Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Matthew J. McGinnis, Leroy P. John, Franc T. Schiet, Charles E. J. Beck
-
Patent number: 5283349Abstract: A 2,6,7-trisubstituted-3-methylenebicyclo-[3.3.0]octane of formula (I) or an enantiomer thereof, or a mixture of these in an arbitrary ratio. The compound is a key intermediate for preparation of isocarbacyclins which are useful as medicines for the circulatory system such as an antithrombotic agent, an antilipidemic agent, a hypotensive agent or an antiarterosclerotic agent.Type: GrantFiled: September 11, 1986Date of Patent: February 1, 1994Assignee: Teijin LimitedInventors: Toshio Tanaka, Kiyoshi Bannai, Seizi Kurozumi
-
Patent number: 5248748Abstract: Disclosed is a diacetylene compound comprising, as structural units, (a) at least one member selected from diacetylene group-containing organic groups of the formulae (I) and (II):R.sup.I --C.tbd.C--C.tbd.C--R.sup.II -- (I)and--R.sup.III --C.tbd.C--C.tbd.C--R.sup.IV -- (II)wherein R.sup.I is hydrogen or a (C1-16) monovalent organic group, and R.sup.II, R.sup.III and R.sup.IV are a (C1-13) divalent organic group,(b) at least one organic group having at least one carbon-to-carbon double bond, and (c) at least one connecting group connecting the units (a) and (b) , which connecting group is selected from amide, imide, ester, ether, amino, imino, urethane, sulfonyl and carbonyl bonds. A cured shaped article made of this compound exhibits isotropically a high elastic modulus and has excellent mechanical properties.Type: GrantFiled: December 19, 1990Date of Patent: September 28, 1993Assignee: Dir. General of Agency of Industrial Science and TechnologyInventors: Katsuyuki Nakamura, Satoru Yamazaki, Jinichiro Kato, Kensaku Tokushige
-
Patent number: 5243080Abstract: The present invention provides a novel compound represented as ##STR1## The present novel compound is prepared by reacting fluorine with pyridine-boron trifluoride and is useful as a fluorinating agent in the fluorination of organic compounds.Type: GrantFiled: July 8, 1992Date of Patent: September 7, 1993Assignee: AlliedSignal Inc.Inventors: Michael Van Der Puy, David Nalewajek, George A. Shia, William J. Wagner
-
Patent number: 5237110Abstract: This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.Type: GrantFiled: February 16, 1990Date of Patent: August 17, 1993Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman, Rafal R. Sicinski, Jean M. Prahl
-
Patent number: 5232836Abstract: Vitamin D derivatives corresponding to the following formula I ##STR1## in which R.sub.1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D.sub.2 (C.sup.20 to C.sup.28) or D.sub.3 (C.sup.20 to C.sup.Type: GrantFiled: February 18, 1992Date of Patent: August 3, 1993Assignee: Ire-Medgenix S.A.Inventors: Roger Bouillon, Pierre J. De Clerco, Pierre Eliard, Maurits Vanderwalle
-
Patent number: 5231220Abstract: Derivatives (I) of norbornylane and of dimethanodecahydornaphthylane of formula: ##STR1## in which: R is the hydrogen atom when n is equal to 1, orR is the acrylol or methacryloyl radical when n is equal to 0 or 1.Also disclosed are processes for the preparation of the derivatives (I) and their application in obtaining polymers and copolymers.Type: GrantFiled: May 14, 1992Date of Patent: July 27, 1993Assignee: NorsolorInventors: Jean Francois Croisy, Paul Grosius
-
Patent number: 5025086Abstract: Provided are 1,5-bis(4-carboxycyclohexyl)-3-pentanol and its esters and processes for their preparation. Also provided are polyester compositions containing this residue, thermosetting coating compositions containing the polyesters, and coatings and casted or molded articles made therefrom.Type: GrantFiled: November 13, 1990Date of Patent: June 18, 1991Assignee: Eastman Kodak CompanyInventors: William W. Blount, Jr., Joseph R. Zoeller
-
Patent number: 5023232Abstract: Novel mixtures of bicylic ethers of the formulas ##STR1## wherein R represents an alkyl group of from one to four carbon atoms, said mixture having at least a 1.1:1 ratio of 1a to 1b, a process for their manufacture and their use as odorants are described.Type: GrantFiled: March 2, 1989Date of Patent: June 11, 1991Assignee: Givaudan CorporationInventors: Georg Frater, Harald Schmidt
-
Patent number: 5015761Abstract: Novel tricycloundecanones are disclosed having the general formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are hydrogen or 1 to 3 carbon alkyl groups having a total carbon number of six or less. These compounds are useful perfumery ingredients characterized by odors of the woody type.Useful derivatives of the compounds are also disclosed as well as a novel procedure for preparation thereof.Type: GrantFiled: December 5, 1988Date of Patent: May 14, 1991Assignee: PFW(Nederland)B.V.Inventors: Willem Lenselink, Gerben Sipma
-
Patent number: 4959349Abstract: Indane derivatives useful as fragrance-imparting components are disclosed. The represented indane derivatives by the formula (I), ##STR1## wherein ring A is a benzene or cyclohexane ring and R.sup.1 is a hydrogen atom, an alkyl group having 1-4 carbon atoms, or an alkanoyl group having 1-6 carbon atoms, provided that when ring A is benzene, R.sup.1 is a group other than hydrogen atom.Type: GrantFiled: February 23, 1990Date of Patent: September 25, 1990Assignee: KAO CorporationInventors: Hiroaki Ohnuma, Yoshiaki Fujikura, Manabu Fujita, Nao Toi
-
Patent number: 4956124Abstract: Bicyclic decanedioic acids corresponding to the following general formula ##STR1## in which R represents a C.sub.1 -C.sub.22 alkyl radical, a C.sub.2 -C.sub.34 alkylcarbonyl radical, or a residue of a polyalkoxylated C.sub.2 -C.sub.22 fatty alcohol, represent a new class of dicarboxylic acids which are useful as flotation aids in the flotation of non-sulfidic ores.Type: GrantFiled: May 11, 1988Date of Patent: September 11, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Horst Eierdanz, Paul Schulz, Wolfgang von Rybinski, Rita Koester
-
Patent number: 4927976Abstract: What is provided herein is a process for preparing 2,3-bis(hydroxyethoxymethyl) bicyclo [2,2,1] heptane (BHEMBCH). In accordance with another feature of the invention, a polyester which is chain extended with BHEMBCH also is provided herein.Type: GrantFiled: September 5, 1989Date of Patent: May 22, 1990Assignee: GAF Chemicals CorporationInventor: Kou-Chang Liu
-
Patent number: 4902672Abstract: Described are polyalkyl indanyl n-propyl and allyl ethers defined according to the structure: ##STR1## wherein R.sub.3 represents methyl or hydrogen; wherein R.sub.1, R.sub.2, R.sub.4 and R.sub.5 each represents methyl or ethyl and wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond with the provisos that:1. at least three of R.sub.1, R.sub.2, R.sub.4 and R.sub.5 represents methyl;2. when each of R.sub.1, R.sub.2, R.sub.4 and R.sub.5 is methyl, then R.sub.3 is methyl; and3. when the dashed line is a carbon-carbon double bond and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each methyland uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles including but not limited to perfumed polymers, solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles, cosmetic powders and hair preparations.Type: GrantFiled: June 26, 1989Date of Patent: February 20, 1990Assignee: International Flavors & Fragrances Inc.Inventors: Mark A. Sprecker, Robert P. Belko, Ronald S. Fenn