Abstract: The present invention seeks to provide novel tetraarylethylene compounds which are substituted on the aryl rings ortho to the ethylenic carbon atoms and processes for the preparation for such compounds. The compounds have potential use as molecular templates.

Abstract: A class of substituted biphenyl compounds is described for use in treating inflammation and inflammation-related disorders.

Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.

Abstract: A method of preparing cumylphenol comprises reacting phenol and alpha-methylstyrene in the presence of an acid catalyst and an alkylbenzene. The method provides an inexpensive, selective process to cumylphenol.

Abstract: Phenol aralkyistion polymers can be prepared by reaction among a phenolic monomer, at least one styrenic monomer and an aryl diolefin. A phenolic monomer can be initially aralkylated in the presence of an acid catalyst with a first portion of at least one styrenic monomer to obtain an aralkylated phenol. The aralkylated phenol thereafter can be reacted with an aryl diolefin to obtain a phenol aralkylation polymer. Optionally, (though preferably) the phenol aralkylation polymer is further aralkylated with a second portion of at least one styrenic monomer. By employing specific catalyst concentrations, reactant concentrations, reaction temperatures, and reaction times, the formation of mono-functional and non-functional by-products is substantially reduced.

Abstract: The subject invention provides a binuclear metal complex having structure (I) wherein M1, and M2 are independently selected from the group consisting of Fe, Co, Mn and Ru; wherein m and n are independently +2 or +3; wherein R1, R2, R3, R4, R5 and R6 are independently a linear C1-C6 alkyl, C5-C6 cycloalkyl, phenyl, etc.; wherein (i) R1 and R2, (ii) R3 and R4, or (iii) R5 and R6 independently and optionally are linked covalently and together with the respective adjoining C atom comprise a spirocyclic ring; wherein i, j and k are integers such that 2≦i+j+k≦4; wherein p is 1 or 2, and q is 0, 1 or 2 such that m+n−4=p×q; wherein (i) R1 or R2 and R3 or R4, (ii) R3 or R4 and R4 or R5, or (iii) R1 or R2 and R5 or R6 independently and optionally are linked covalently and together with the respective adjoining C atoms comprise a fused ring; wherein Ar is 1,2-phenylene, 1,2- or 2,3-naphthylene, etc.

Abstract: A liquid composition of phenolic compounds can be formed in the substantial absence of a solvent and a surfactant. This composition includes at least one substituted phenol and a halo-substituted phenol. In one embodiment, the composition includes benzylchlorophenol and at least one of phenylphenol and tert-pentylphenol. In another embodiment, the composition includes benzylchlorophenol, phenylphenol, and tert-pentylphenol. The composition may be useful for preparing an antimicrobial material. A liquid phenolic composition can be prepared by forming a composition having at least one substituted phenol and a halo-substituted phenol in the substantial absence of a solvent and surfactant and mixing the composition until a liquid phenolic composition is formed.

Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.

Abstract: Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

Abstract: Novel pharmaceutically/cosmetically-active triaromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

Abstract: The present invention relates to a process for the hydroxylation of phenolic compounds and, more particularly, to a process for the hydroxylation of phenols and phenolic ethers with hydrogen peroxide. The invention relates to a process for the hydroxylation of phenolic compounds using hydrogen peroxide, said process being characterized in that the reaction is carried out in the presence of an effective quantity of at least one rare earth or bismuth triflate.

Abstract: The present invention is directed to the formation of phenol alkylation polymers which release negligible phenol and formaldehyde emissions. The phenol aralkylation polymers of the present invention are derived from a phenolic monomer, at least one styrene derivative and an aryl diolefin. In addition to the phenolic monomer, styrene derivative and aryl diolefin, other reactants may be introduced to produce a product with particular properties.

Abstract: The present invention is directed to the formation of phenol alkylation polymers which release negligible phenol and formaldehyde emissions. The phenol aralkylation polymers of the present invention are derived from a phenolic monomer, at least one styrene derivative and an aryl diolefin. In addition to the phenolic monomer, styrene derivative and aryl diolefin, other reactants may be introduced to produce a product with particular properties.

Abstract: The present invention is directed to the formation of phenol alkylation polymers which release negligible phenol and formaldehyde emissions. The phenol aralkylation polymers of the present invention are derived from a phenolic monomer, at least one styrene derivative and an aryl diolefin. In addition to the phenolic monomer, styrene derivative and aryl diolefin, other reactants may be introduced to produce a product with particular properties.

Abstract: The invention relates to the preparation of a transparent crystalline adduct consisting of bisphenol A (75 parts) and bisphenol TMC (25 parts), which has a melting point of 144.degree. C. which is below the melting points of the pure starting compounds bisphenol A (157.degree. C.) and bisphenol TMC (208.degree. C.).

Abstract: The present invention is directed to the formation of phenol alkylation polymers which release negligible phenol and formaldehyde emissions. The phenol aralkylation polymers of the present invention are derived from a phenolic monomer, at least one styrene derivative and an aryl diolefin. In addition to the phenolic monomer, styrene derivative and aryl diolefin. In addition to the introduced to produce a product with particular properties.

Abstract: The present invention is directed to the formation of phenol alkylation polymers which release negligible phenol and formaldehyde emissions. The phenol aralkylation polymers of the present invention are derived from a phenolic monomer, at least one styrene derivative and an aryl diolefin. In addition to the phenolic monomer, styrene derivative and aryl diolefin, other reactants may be introduced to produce a product with particular properties.

Abstract: Disclosed is a process for the preparation of 2-(1-arylethyl)hydroquinones by the reaction of a hydroquinone compound with an arylvinyl compound in the presence of a phosphoric acid alkylation catalyst in a two-phase liquid reaction medium comprising water and a water-immiscible organic solvent. Formation of the corresponding bis-(1-arylethyl)hydroquinone is minimized resulting in excellent selectivity to the mono-(1-arylethyl)hydroquinone compound.

Abstract: A process of catalytically reacting a 3-18 carbon mono-olefin such as cyclohexene with an arylhydroxide such as phenol in the liquid phase forming an ortho-alkylated arylhydroxide which is subsequently catalytically dehydrogentated to form an ortho-alkenylarylhydroxide or ortho-arylarylhydroxide such as ortho-phenylphenol.

Abstract: An optically active tri-substituted methane compound having, as substituents, an aromatic ring group and a phenyl group having hydroxyl group at ortho or para position can be obtained by allowing a phenol compound unsubstituted at the ortho- or/and para-position to react with an optically active secondary carbinol compound having an aromatic ring group at the alpha-position in the presence of tri-substituted phosphine and diazodicarboxylate or diazodicarboxamide. These and other optically active tri-substituted methane compounds are useful as active ingredients for medicines or as intermediate compounds for preparing medicines.

Abstract: The production of cis-dihydrodiol compounds of the formula ##STR1## where n is 0 or 1 (preferably 0) by the microbial oxidation of a diphenylaceylene compound of the formula ##STR2## using a mutant of a Pseudomonas bacteria at 25.degree. to 35.degree. C. and pH 6-8 is disclosed. The cis-dihydrodiol compound is in turn treated with an aqueous solution of a base to produce a corresponding 3-hydroxydiphenylacetylene compound or with an aqueous solution of an acid to produce a corresponding 2-hydroxyacetylene compound.

Abstract: A novolac resin is prepared by reacting a phenolic compound, an aldehyde or a ketone, and a hydroxyl-substituted benzocyclobutene compound wherein the hydroxyl group is attached to an aromatic ring. The benzocyclobutenes are connected to the phenolic rings through an oxygen or oxyaryl bridge, or the cyclobutene is fused directly to a phenol ring. The novolac resin cures without evolution of volatiles and, when cured, provides a polymer which has a high glass transition temperature and which is essentially insoluble in organic solvents.

Abstract: Para-cumylphenol is continuously produced by the reaction of purified phenol and alpha-methylatyrene in the presence of an acidic catalyst and an effective amount of hypophosphorous acid (H.sub.3 PO.sub.2) for stabilizing the color and UV absorption.

Abstract: The invention relates to a process for the preparation of p-substituted o-benzylphenols by reaction of p-substituted phenols with optionally substituted benzyl halides, benzyl esters, benzyl alcohols or benzyl ethers in the presence of an acid catalyst at elevated temperature in a distillation column.

Abstract: A diphenylmethane compound (III) can be produced in a good yield by allowing a phenol compound (I) to react with a stilbene compound (II) in the presence of methanesulfonic acid ##STR1##

Abstract: Provided is an improved process for preparing 2-(1-phenylethyl)hydroquinone and its diacetate salt. In this process, the differential solubility of product and starting materials hydroquinone and styrene in non-polar organic solvents is utilized to provide mono-alkylated materials which can be easily removed from the reaction mixture. A solid acid catalyst is also used which allows the isolation of product and recycle of unreacted starting materials to be accomplished on an industrial-scale continuous process.

Abstract: A method for preparing paracumylphenol in a highly selective manner which comprisesa. reacting alpha methylstyrene with a purity greater than about 99.5 wt. % with a molecular excess of phenol having a purity greater than about 99.95 wt. % in the contact presence of a solid organic cation exchange resin at a temperature of from about 40.degree. C. to about 100.degree. C. and obtaining a stream containing paracumylphenol, phenol and small quantitities of side reaction products comprising orthocumylphenol and alpha methylstyrene dimers,b. removing excess phenol and other unwanted materials which are lower boiling than paracumylphenol, thereby leaving a stream which is at least about 99 wt. % paracumylphenol.

Abstract: Quinone derivatives of the general formula: ##STR1## (wherein R.sup.1 and R.sup.2 are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R.sup.1 and R.sup.2 combine with each other to represent --CH.dbd.CH--CH.dbd.CH--R.sup.3 is a hydrogen atom or a methyl group; R.sup.4 is an aliphatic, aromatic or heterocyclic group which may be substituted; R.sup.5 is a methyl or methoxy group, a hydroxymethyl group which may be substituted or a carboxyl group which may be esterified or amidated; Z is a group represented by --C.dbd.C--, --CH.dbd.CH--, ##STR2## n is an integer of 0 to 10; m is an integer of 0 to 3; k is an integer of 0 to 5, provided, however, that in the case of m being 2 or 3, Z and k can vary arbitrarily within the bracketed repeating units) are novel compounds, possess metabolism ameliorating action for polyunsaturated fatty acids, particularly production inhibitory activity of lipid peroxides (antioxidant activity), thromboxane A.sub.

Abstract: 1-Aminoanthraquinone (1-AAQ) is synthesized by the reaction of 2-chlorobenzyl chloride and xylene in the presence of a solid acid catalyst to yield 2-chloro dimethyldiphenylmethane, subsequent oxidation of the methyl groups, ring closure to form a 1-chloroanthraquinone carboxylic acid, replacement of the 1-chloro group with ammonia, and decarboxylation.

Abstract: Method of preparing para-cumylphenol including reacting an excess of phenol with alpha-methylstyrene by the slow addition of alpha-methylstyrene to a 50% to 200% molar excess of phenol at a temperature from about 80.degree. C. to about 90.degree. C. in the presence of an acid catalyst and thereafter maintaining the temperature at about 95.degree. to about 100.degree. C. to obtain a crude cumylphenol reaction product containing acid derived from the catalyst, and distilling the reaction product in the presence of an amount of base sufficient to neutralize the acid therein.

Abstract: The 2-alkyl-6-t-butyl-4-(pentamethylbenzyl)phenols in which the 2-alkyl group is t-butyl or methyl are novel compounds having melting points sufficiently low to make them attractive as antioxidants for low melting polymers such as polyethylene, polypropylene, and polystyrene.

Abstract: Para-substituted o-benzylphenols are prepared by reacting p-substituted phenols with benzylating agents in the presence of zeolites of the faujasite type at elevated temperature.

Abstract: An optically active compound represented by the general formula (I) of:R--Z--COO--(Ph).sub.k --Ph(Y)--CO--(CH.sub.2).sub.m C*HE L (1)In the general formula (I); R is an alkyl or alkoxy group having 4 to 22 carbon atoms; Z is the one selected from the group consisting of --Ph--, --Ph(X)--, --Ph--Ph--, Ph(X)--Ph--, --Ph--cy--, --Ph(X)--cy-- and --py--Ph-- is a 1,4-substituted phenylene group; --Ph--Ph-- is a 4,4'-substituted diphenylene group; --cy-- is a trans-1,4-cyclohexane group, --py is 2,5-substituted pyrimide group; X is a halogen atom at the ortho-position to R; k is zero or 1, Y is the one selected from the group consisting of H, OH, halogen atoms and methyl group; C* is an asymmetric carbon atom; E is the one selected from the group consisting of methyl group, halogen atoms and CF.sub.3 ; L is an alkyl, aryl or aralkyl group having not more than 10 carbon atoms; and m is an integer of zero to 6 where m takes zero when Y is H and Z is --Ph-- or --Ph--Ph--.

Abstract: Process for the alkylation of phenols comprising reacting a phenol with a vinyl-aromatic hydrocarbon in the presence of an acidic catalyst and of a solvent.

Abstract: A process for alkylation of phenols comprising letting a phenol react with a vinyl-aromatic hydrocarbon substituted in the vinyl group, in the presence of an organic solvent and of an acid catalyst in an aqueous solution, and of a polymerization inhibitor.

Abstract: Substituted diallylphenol derivatives are useful as reactive diluents for bismaleimides. Formulations comprising bismaleimides and substituted diallylphenol derivatives are particularly useful in resin transfer molding and filament winding techniques.

Abstract: An improved process for preparing dithiobisphenols comprising reacting an appropriate phenol with an alkali metal hydride, an alkaline earth metal hydride or mixtures thereof and subsequently reacting the product thereof with sulfur monochloride.

Abstract: Ortho-aromatic diaryl ethers, such as o-biphenylyl phenyl ether, are hydrolyzed to corresponding phenolic compounds, such as o-phenylphenol and phenol, when contacted with water in the presence of ceria or thoria at a temperature of between about 250.degree. C. and 700.degree. C.

Abstract: A process for the preparation of phenylhydroquinone by the reaction of a mixture of a benzenediazonium salt, hydroquinone and water while maintaining the pH in the range of about 3 to about 9.

Abstract: A process for preparing p-cumylphenol which comprises reacting phenol and .alpha.-methylstyrene in the presence of an inorganic solid acid catalyst having an acid point of an acid strength Ho of up to -3, for example, activated clay and recovering the aimed p-cumylphenol from the reaction mixture thus obtained by distilling the same while introducing an inert gas such as nitrogen and/or steam into the distillation system is disclosed. The p-cumylphenol thus obtained has a high purity and an improved color compared with those obtained by conventional methods.

Abstract: A process for preparing hydroxybiphenyls. A bromobiphenyl is contacted with a base in aqueous liquid phase at a temperature less than or equal to 230.degree. C. in the presence of a copper-based catalyst. The hydroxyl ion concentration of base ranges from 0.1 to about 1.6 molar equivalents per liter. At temperatures less than 215.degree. C., a cocatalyst is preferably added.

Abstract: Cyclohexane derivatives of formula I ##STR1## wherein R is an alkyl group which has 1-12 C atoms and in which one or two non-adjacent CH.sub.2 groups can also be replaced by O, --CO--O-- or --OCO--,A.sup.1 and A.sup.2 each independently of one another are trans-1,4-cyclohexylene or unsubstituted or fluorine-substituted 1,4-phenylene, and one of the groups A.sup.1 and A.sup.2 can also be a single bond,X is --CN, halogen, OH, --COOR.sup.1, --OOCR.sup.1, --COR.sup.1, --OR.sup.1 or R.sup.1 andR.sup.1 is an alkyl group which has 1-12 C atoms and in which one or two CH.sub.2 groups can also be replaced by O, but excluding direct links between two O atoms,with the proviso that, in the case of X=CN, A.sup.2 is trans-1,4-cyclohexylene or fluorine-substituted, 1,4-phenylene, are suitable as components of liquid-crystalline phases.

Abstract: A method for selective dehydrogenation of a compound, comprising contacting a compound of the formula ##STR1## wherein each R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is independently selected from the group consisting of H, (C.sub.1 -C.sub.20) alkyl, (C.sub.3 -C.sub.20) cycloalkyl, (C.sub.6 -C.sub.20) aryl, (C.sub.7 -C.sub.20) alkylaryl, (C.sub.7 -C.sub.20) aralkyl groups, as well as substituted (C.sub.1 -C.sub.20) alkyl, (C.sub.3 -C.sub.20) cycloalkyl, (C.sub.6 -C.sub.20) aryl, (C.sub.7 -C.sub.20) aralkyl and (C.sub.7 -C.sub.20) arylalkyl moieties, optionally further substituted with --OR, wherein R is R.sup.1, R.sup.2, R.sup.3 or R.sup.4 ; and wherein R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 may be joined as part of a ring structure, at a dehydrogenation temperature in the presence of a catalyst comprising about 0.01 wt %-19.9 wt % Pd and about 0.01 wt %-19.9 wt % Cu on a carbon support, wherein the total amount of (Pd+Cu) on the support is about 0.

Abstract: A method for synthesizing a tri-substituted phenyl compound (I) by using a 1,2-addition followed by a 1,4-addition to 1,4-benzoquinone (II): ##STR1## wherein X is hydroxy, alkoxy or alkanoyloxy, Ar.sup.1 is an organic group and R is an unsubstituted or substituted alkyl group.

Abstract: An improved process is provided for synthesizing monosubstituted (1-phenylethyl) hydroquinone in high yields and with little contamination by disubstituted (1-phenylethyl) hydroquinone. The process is performed by reacting styrene and hydroquinone using a zeolite molecular sieve.

Abstract: Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.

Abstract: Novel ring-brominated derivatives of the diepoxides of tetraalkyl dihydroxydiaromatic compounds, e.g., the diglycidyl ether of 3,5-dibromo-4-(2-(2-bromo-4-hydroxy-3,5-dimethylphenyl)ethyl)-2,6-dimethyl phenol.

Abstract: Styrene and hydroquinone are reacted to produce (1-phenylethyl) hydroquinone, i.e.

Abstract: Compounds with 3,5-dibenzyl-4-hydroxyphenyl substituents have good thermal stability. Organic compositions containing the new additives are protected from oxidative degradation.

Abstract: A new process for preparing spirobiindanols, comprising refluxing the corresponding alkylaryl bisphenyl derivative in the presence of a dry heterogeneous acid catalyst in toluene, is disclosed.