The Two Cyclos Share At Least Three Ring Carbons (i.e., Bridged Ring) Patents (Class 568/820)
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Publication number: 20140271733Abstract: Pharmaceutical compositions and methods of use therefor for reducing the desire to engage in smoking are disclosed. More specifically, the pharmaceutical composition utilizes an active ingredient to reduce the side effects of smoking cessation and to limit the molecular feedback caused by nicotine-mediated activation of acetylcholine receptors.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Philip Morris USA Inc.Inventors: Gerd Kobal, Justin Heynekamp, Peter Reeh, Munmaya K. Mishra
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Patent number: 8822733Abstract: The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, and wherein the dotted line may represents an additional bond and Ra represents a hydrogen atom or a Si(Rb)3 or (Rb)2COH group, each Rb representing C1-6 alkyl group or a phenyl group. The invention concerns also the compound (I) as well as its use for the synthesis of ?-santalol or of derivatives thereof.Type: GrantFiled: February 8, 2012Date of Patent: September 2, 2014Assignee: Firmenich SAInventor: Christian Chapuis
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Publication number: 20130310609Abstract: The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, and wherein the dotted line may represents an additional bond and Ra represents a hydrogen atom or a Si(Rb)3 or (Rb)2COH group, each Rb representing C1-6 alkyl group or a phenyl group. The invention concerns also the compound (I) as well as its use for the synthesis of ?-santalol or of derivatives thereof.Type: ApplicationFiled: February 8, 2012Publication date: November 21, 2013Applicant: FIRMENICH SAInventor: Christian Chapuis
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Publication number: 20130303433Abstract: 1-(3/4-isobutyl-1/6-methylcyclohex-3-enyl)methanols and derivatives thereof having appreciable floral and hesperidic odor notes, their use as fragrance ingredient and perfumed products comprising them.Type: ApplicationFiled: August 11, 2011Publication date: November 14, 2013Applicant: Givaudan S.A.Inventors: Jerzy A. Bajgrowicz, Christopher Furniss
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Patent number: 8486464Abstract: This invention provides compositions comprising extracts of Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneol. Said compositions comprise notoginsenoside R1 and ginsenoside Rg1 which are active components for therapeutic applications. This invention also provides a method of preparation of the said compositions and a method of identification and determination of the amount of individual effective components of said compositions. Finally, this invention provides various uses of the compositions.Type: GrantFiled: July 31, 2002Date of Patent: July 16, 2013Assignee: Tasly Pharmaceutical Group Co. Ltd.Inventors: Xijun Yan, Naifeng Wu, Zhixin Guo, Zhengliang Ye, Yan Liu
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Publication number: 20130096209Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.Type: ApplicationFiled: April 15, 2011Publication date: April 18, 2013Applicants: Kraft Foods Global Brands LLC, Chromocell CorporationInventors: David Hayashi, William P. Jones, Jane V. Leland, Peter H. Brown, Joseph Gunnet, Daniel Lavery, Louise Slade, Kambiz Shekdar, Jessica Langer
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Patent number: 8309511Abstract: The present invention is directed to novel fragrance compounds and their unexpected advantageous use in enhancing, improving or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the compounds, wherein the compounds are represented by the following formula: wherein a methyl group is bonded to the 5-membered ring at position 2 or 3, or a mixture thereof.Type: GrantFiled: May 22, 2012Date of Patent: November 13, 2012Assignee: International Flavors & Fragrances Inc.Inventors: Richard A. Weiss, Anubhav P. S. Narula, James Anthony Lasome, Richard M. Boden
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Publication number: 20120149848Abstract: The present invention relates to a photoreactive polymer that comprises a multi-cyclic compound in a main chain, and a polymerization method thereof. Since the photoreactive polymer according to the present invention comprises a multi-cyclic compound having a high glass transition temperature as a main chain, the thermal stability is excellent, and since the mobility of the main chain is relatively high as compared to that of an additional polymer, a photoreactive group can be freely moved in the main chain of the polymer. Accordingly, it is possible to overcome a slow photoreactive rate that is considered a disadvantage of a polymer material used to prepare an alignment film for known liquid crystal display devices.Type: ApplicationFiled: December 15, 2011Publication date: June 14, 2012Inventors: Dai-Seung CHOI, Hye-Young JUNG, Sung-Ho CHUN, Heon KIM, Sung-Don HONG, Dong-Woo YOO
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Publication number: 20120059196Abstract: A method for preparing a terpenylcyclohexanol using a terpenylphenol is described. A method for preparing a terpenylcyclohexanol by hydrogenation of a terpenylphenol is also described wherein the method includes hydrogenating the latter in a liquid phase, in the presence of a Raney nickel catalyst including residual aluminium and doped with a mixture of iron and chromium.Type: ApplicationFiled: April 21, 2010Publication date: March 8, 2012Applicant: RHODIA OPERATIONSInventor: Roland Jacquot
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Publication number: 20110281949Abstract: Use of alkyl phenol and monocyclic monoterpene-derived compounds in the treatment of neuronal damage and in inhibiting activity of TRPC and non-thermo-TRPM channels, and use of bicyclic monoterpene-derived compounds in activating TRPC and non-thermo-TRPM channels.Type: ApplicationFiled: February 3, 2011Publication date: November 17, 2011Inventors: Baruch Minke, Moshe Parnas
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Publication number: 20100231844Abstract: A liquid crystal composition comprising at least one compound having a fluorobicyclo[2.2.2]octane skeleton represented by formula (I) below is disclosed. A fluorobicyclo[2.2.2]octane compound represented by formula (II) below is also disclosed. In the formulae, Y represents a hydrogen atom or fluorine atom.Type: ApplicationFiled: March 11, 2010Publication date: September 16, 2010Applicant: FUJIFILM CorporationInventors: Takashi Miyahara, Masayuki Harada
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Publication number: 20100204422Abstract: The present invention relates to, for example, a fluorine-containing cyclic compound represented by the following general formula (1). In the general formula (1), R1a is a C1-C25 cyclic alkyl group, cyclic alkenyl group or cyclic alkynyl group; each of R2 and R3 is independently a hydrogen atom, a halogen atom, or a C1-C25 straight-chain, branched or cyclic alkyl group; and each of R1a, R2 and R3 may contain fluorine atom, oxygen atom, sulfur atom, nitrogen atom or an atomic group containing a carbon-carbon double bond.Type: ApplicationFiled: April 22, 2010Publication date: August 12, 2010Applicant: Central Glass Company, LimitedInventors: Haruhiko Komoriya, Shinichi Sumida, Michitaka Ootani, Takeo Komata, Kazuhiko Maeda
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Publication number: 20100145107Abstract: The present invention a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of a compound of formula: wherein R is absent, hydrogen or methyl; R1, R2, and R3 are independently hydrogen or methyl; and the broken lines represent independently single or double bonds, with the proviso that when R1, R2, and R3 are hydrogen, R is methyl.Type: ApplicationFiled: February 18, 2010Publication date: June 10, 2010Inventors: Feng Geng, Richard M. Boden
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Patent number: 7662996Abstract: Embodiments in accordance with the present invention provide for forming essentially pure diastereomers of 5/6-substituted norbornene-type monomers. Further, embodiments in accordance with the present invention encompass polymerizing such diastereomers to form addition or ROMP polymers where a desired exo-/endo-ratio of the diastereomers is provided to the polymerization, such ratio designed to provide a desired ratio of endo-/exo-structured repeating units for a resulting polymer to have desired physical or chemical properties.Type: GrantFiled: October 31, 2008Date of Patent: February 16, 2010Assignee: Promerus, LLCInventors: Andrew Bell, Brian Knapp, Dane Jablonski, Dietrich Fabricius, Peter Wyatt Newsome
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Publication number: 20090192330Abstract: To provide a novel polymerizable fluorocompound having a highly fluorinated norbornane structure, and a polymer obtained from the compound. Further, their production processes and a novel intermediate useful for the processes. A novel compound (1) such as a compound (11) or a compound (12), and its polymer. A compound (2) such as a compound (21) or (22), and a compound (3) such as a compound (31) or (32M), which are useful as an intermediate for the production of the compound (1), and its production process. However, each of ZA to ZE represents such as —CH(—OC(O)C(CH3)?CH2)— or —CF2, Each of WA and WB represents such as F, each of YA to YE represents such as —CH(—OH)— or —CF(CH2OH), and each of XA to XE represents such as —C(O)— or —CF2—.Type: ApplicationFiled: January 12, 2009Publication date: July 30, 2009Applicant: ASAHI GLASS COMPANY, LIMITEDInventors: Yasuhisa MATSUKAWA, Daisuke SHIRAKAWA, Eisuke MUROTANI, Naoko SHIROTA, Yoko TAKEBE
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Publication number: 20090118539Abstract: Embodiments in accordance with the present invention provide for forming essentially pure diastereomers of 5/6-substituted norbornene-type monomers. Further, embodiments in accordance with the present invention encompass polymerizing such diastereomers to form addition or ROMP polymers where a desired exo-/endo-ratio of the diastereomers is provided to the polymerization, such ratio designed to provide a desired ratio of endo-/exo-structured repeating units for a resulting polymer to have desired physical or chemical properties.Type: ApplicationFiled: October 31, 2008Publication date: May 7, 2009Applicant: PROMERUS, LLCInventors: Andrew Bell, Brian Knapp, Dane Jablonski, Dietrich Fabricius, Peter Wyatt Newsome
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Publication number: 20080274927Abstract: The present invention relates to substituted bicyclo[3.3.1]nonanes and bicyclo[3.3.1]nonenes of formula (I) wherein R, and R1 to R5 have the same meaning as described in the specification.Type: ApplicationFiled: January 14, 2005Publication date: November 6, 2008Applicant: GIVAUDAN SAInventors: Thierry Granier, Andreas Hanhart, Jerzy A. Bajgrowicz
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Patent number: 7396961Abstract: The present invention relates to a process for decomposing organic hydroperoxides in the presence of a catalyst. It provides a process for decomposing organic hydroperoxides in the presence of a catalyst into a mixture of alcohols and ketones, in which the catalyst comprises at least one ruthenium-based catalytically active metallic element incorporated into a solid support chosen from the group comprising metal oxides and carbon blacks, such as the carbon blacks obtained by the pyrolysis of organic compounds. The process of the invention is especially useful in the decomposition of important chemical intermediates such as cyclohexyl hydroperoxide.Type: GrantFiled: January 20, 2006Date of Patent: July 8, 2008Assignee: Rhodia Polyamide IntermediatesInventors: Didier Bonnet, Eric Fache, Aline Seigneurin
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Patent number: 7112700Abstract: An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed. The starting materials used in the synthesis are inexpensive. The principal starting material, (?)-?-Pinene, is on the GRAS list (generally recognized as safe).Type: GrantFiled: April 14, 2005Date of Patent: September 26, 2006Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Anne M. Sauer, William E. Crowe, Roger A. Laine, Gregg Henderson
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Patent number: 7060664Abstract: Bicyclo[2.2.1]heptanes or heptenes mono-substituted at the 7-position with a substituent selected from the group consisting of linear or branched C2-10 alkyl or alkenyl, and alkylidene, and fragrance compositions containing same.Type: GrantFiled: December 4, 2002Date of Patent: June 13, 2006Assignee: Givaudan SAInventor: Andreas Goeke
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Patent number: 7019150Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.Type: GrantFiled: August 7, 2003Date of Patent: March 28, 2006Assignee: Florida State UniversityInventors: Robert A. Holton, Suhan Tang, Feng Liang, Carmen Somoza
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Patent number: 6858760Abstract: A fluorine-containing cyclic compound is represented by the formula 1: wherein each of R1, R2 and R3 independently represents a hydrogen, alkyl group, fluorine, fluoroalkyl group or hexafluorocarbinol group, wherein at least one of the hexafluorocarbinol groups may partly or totally be protected with a protecting group, and wherein the protecting group is (a) a straight-chain, branched or cyclic hydrocarbon group having a carbon atom number of 1-25 or (b) an aromatic hydrocarbon group and optionally contains a fluorine atom, oxygen atom, nitrogen atom or carbonyl bond.Type: GrantFiled: February 20, 2004Date of Patent: February 22, 2005Assignee: Central Glass Company, LimitedInventors: Haruhiko Komoriya, Satoru Miyazawa, Katsunori Kawamura, Satoru Kobayashi, Kazuhiko Maeda
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Patent number: 6849767Abstract: A method of hydroborating an alkene or alkyne, or reducing an organic functionality, oxidizing primary and secondary alcohols using a fluorous borane-sulfide is disclosed. The method includes regeneration and recycling the fluorous borane-sulfide.Type: GrantFiled: July 24, 2003Date of Patent: February 1, 2005Assignee: The Board of Trustees of the University of IllinoisInventors: David C. Crich, Santhosh Neelamkavil
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Patent number: 6818779Abstract: A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, wherein Y is (CH2)x; Z is selected from the group consisting of x is an integer of 1 or 2; n is 0 or 1; R2 is hydrogen or an alkyl radical of from 1 to 4 carbons; A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups or said alkylene or alkenylene may have one or more enchained oxa or imino radicals; B is a methyl radical or a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals wherein tType: GrantFiled: August 5, 2002Date of Patent: November 16, 2004Assignee: Allergan, Inc.Inventors: Robert M. Burk, Achim H-P Krauss, David F. Woodward
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Publication number: 20040225159Abstract: A fluorine-containing cyclic compound is represented by the formula 1: 1Type: ApplicationFiled: February 20, 2004Publication date: November 11, 2004Applicant: Central Glass Company, Ltd.Inventors: Haruhiko Komoriya, Satoru Miyazawa, Katsunori Kawamura, Satoru Kobayashi, Kazuhiko Maeda
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Patent number: 6639095Abstract: The present invention provides a process for preparing optically active &agr;-hydroxy acids and derivatives thereof by subjecting the alkylated 1,3-dioxolanones of formula (IV) wherein R1 and R2 are the same or different and are each independently H or C1-6 alkyl; R5 is H, C1-16 alkyl, or unsubstituted or substituted phenyl; and R6 is C1-8 alkyl, C2-7 alkenyl or unsubstituted or substituted benzyl, to either alcoholysis or hydrolysis, in which the alkylated 1,3-dioxolanones are obtained by using 10-camphorsulfonamide as a chiral auxiliary.Type: GrantFiled: October 8, 2002Date of Patent: October 28, 2003Inventors: Biing-Jiun Uang, Jia-Wen Chang, Der-Pin Jang
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Patent number: 6632331Abstract: Aldehyde compounds contained in polycyclic diols as impurities are effectively removed by distilling the polycyclic diols in the presence of an alkali metal compound and/or a alkaline earth compound. The distilled polycyclic diols are useful as a diol component of a polymer such as polycarbonate with less yellowing.Type: GrantFiled: July 26, 2001Date of Patent: October 14, 2003Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Shu Yoshida, Satoshi Nagai, Takashi Konishi, Makoto Sasaki
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Publication number: 20030183502Abstract: A process for purifying alicyclic alcohols by distillation, wherein the alicyclic alcohols are distilled in the presence of from 1 to 550 ppm of acidic compounds.Type: ApplicationFiled: December 13, 2002Publication date: October 2, 2003Inventors: Wolfgang Dukat, Peter Lappe, Klaus Schmid, Horst Scholz, Edgar Storm
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Patent number: 6469220Abstract: The present invention provides novel tertiary alcohol compounds which are useful as monomers for the preparation of photoresist materials having high transparency and a great affinity for the substrate and hence suitable for use in photolithography using a light source comprising preferably light having a wavelength of 300 nm or less and more preferably light emitted from an ArF excimer laser. Specifically, the present invention provides tertiary alcohols compounds represented by the following general formula (1): wherein R1 and R2 each independently represent a straigh-chain, branched or cyclic alkyl group having 1 to 10 carbon atoms, in which some or all of the hydrogen atoms on the constituent carbon atoms may be replaced by a halogen atom or halogen atoms, or R1 and R2 may be joined together to form an aliphatic hydrocarbon ring; Z represents a straight-chain, branched or cyclic divalent organic group having 2 to 10 carbon atoms; and k is 0 or 1.Type: GrantFiled: December 19, 2001Date of Patent: October 22, 2002Assignee: Shin-etsu Chemical Co., Ltd.Inventors: Koji Hasegawa, Takeshi Kinsho, Takeru Watanabe
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Publication number: 20020087033Abstract: The present invention provides novel tertiary alcohol compounds which are useful as monomers for the preparation of photoresist materials having high transparency and a great affinity for the substrate and hence suitable for use in photolithography using a light source comprising preferably light having a wavelength of 300 nm or less and more preferably light emitted from an ArF excimer laser.Type: ApplicationFiled: December 19, 2001Publication date: July 4, 2002Inventors: Koji Hasegawa, Takeshi Kinsho, Takeru Watanabe
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Patent number: 6235926Abstract: The present invention relates to perfumery of compounds of the general formula in which R1 and R2 are identical or different and represent each a methyl or ethyl group, R3 represents hydrogen or an alkyl group from C1 to C4, linear or branched, and R4 represents hydrogen, an alkyl group from C1 to C4, linear or branched, or an acyl group of formula R5C(O)—, R5 being hydrogen or an alkyl group from C1 to C4, linear or branched. The novel odoriferous character of these compounds is the combination of woody with fruity notes.Type: GrantFiled: September 16, 1999Date of Patent: May 22, 2001Assignee: Firmenich SAInventors: Karl-Heinrich Schulte-Elte, Hervé Pamingle, Christian Vial
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Patent number: 6214888Abstract: The present invention relates to novel monocyclic and bicyclic monoterpene diols that stimulate melanogenesis in mammalian skin, hair, wool or fur, and, are useful for treating or preventing various skin and proliferative disorders, neurodegenerative diseases, and diseases regulated by the nitric oxide/cyclic GMP/protein kinase G pathway.Type: GrantFiled: May 28, 1998Date of Patent: April 10, 2001Assignee: Applied Genetics IncorporatedInventors: Wu Yun Ren, David A. Brown
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Patent number: 6075156Abstract: A cycloalkanol is prepared by cycloaddition between a diene and a vinyl ester, wherein the ester is derived from a carboxylic acid of sufficient molecular weight to enable the reaction to be carried out at atmospheric pressure while above 150.degree. C., and the corresponding reaction between the diene and vinyl acetate generates a pressure above 4 atmospheres.Type: GrantFiled: December 23, 1997Date of Patent: June 13, 2000Assignee: Chirotech Technology LimitedInventors: Stephen John Clifford Taylor, Raymond McCague, Derek Thomas Edward Jones
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Patent number: 5948933Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.Type: GrantFiled: July 11, 1997Date of Patent: September 7, 1999Assignees: Organix, Inc., President and Fellows of Harvard CollegeInventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Zhengming Chen
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Patent number: 5874648Abstract: To prepare isocamphylcyclohexanols by hydrogenating compounds containing the carbon skeleton of the isocamphylguaiacols or isocamphylphenols, oxygen-free and support-free molded bodies disposed in a fixed bed and made of compacted powders of the elements of the ferrous subgroup of group VIII of the periodic system or their mutual alloys or their alloys with elements of group VIB are used as catalysts; in addition, hydrogenationally inert elements may be present. The molded bodies have a compressive strength of 20 to 250N and an internal surface area of 10 to 90 m.sup.2 /g.Type: GrantFiled: September 12, 1997Date of Patent: February 23, 1999Assignee: Bayer AktiengesellschaftInventor: Gerhard Darsow
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Patent number: 5789374Abstract: Described are methyl-substituted 1(2-norbornyl) alkanols and acetate esters thereof defined according to the structures: ##STR1## (wherein Z represents hydrogen or acetyl). The compounds wherein Z is acetyl, the esters, are useful in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles, such as solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softeners, fabric softener articles, hair sprays, shampoos, bath oils and perfumed polymers. Also described are process intermediates for making such compounds defined according to the structures: ##STR2## wherein M' represents MgX or Li and wherein X represents chloro, bromo or iodo.Type: GrantFiled: October 18, 1996Date of Patent: August 4, 1998Assignee: International Flavors & Fragrances Inc.Inventors: Mark A. Sprecker, Richard A. Weiss, Marie R. Hanna
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Patent number: 5741880Abstract: A hydroxy-functional polymer having a number average molecular weight, as determined by gel permeation chromatography, of from about 1800 to about 2700 and which consists essentially of polymerized monomers of 10-40% by weight, based on the total weight of the polymer, styrene; 20-55% by weight isobornyl methacrylate; and 20-55% by weight hydroxypropyl methacrylate; where the total of the monomers equals 100% are disclosed. The polymers are especially useful in combination with polyisocyanates as clearcoats in clearcoat/basecoat coating applications.Type: GrantFiled: April 28, 1997Date of Patent: April 21, 1998Assignee: The Sherwin-Williams CompanyInventors: Richard S. Valpey, III, Eugene I. Bzowej
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Patent number: 5354915Abstract: This invention provides an improved process for converting .alpha.,.beta.-olefinically unsaturated aldehydic or ketonic compounds into the corresponding allylic alcohol using an alcohol as a hydrogen donor. This process is conducted in the presence of a supported tetragonal zirconium oxide catalyst or supported HfO.sub.2, V.sub.2 O.sub.5, NbO.sub.5, TiO.sub.2 and Ta.sub.2 O.sub.5 catalysts.Type: GrantFiled: December 21, 1992Date of Patent: October 11, 1994Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventor: Walter T. Reichle
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Patent number: 5321007Abstract: Described are 2,6-dimethylbicyclo[3.3.1]non-6-ene-3-methanol and substituted derivatives thereof defined according to the generic structure: ##STR1## wherein each of the dashed lines represents a carbon-oxygen covalent bond or no bond; N is 0 or 1; R.sub.1 represents hydrogen, C.sub.1 -C.sub.2 lower alkyl, lower alkenyl, lower alkylenyl, C.sub.1 -C.sub.2 acyl, alkoxycarbonyl, magnesium halo or lithium; and R.sub.2 represents methyl or hydrogen as well as uses thereof (wherein R.sub.1 is not magnesium halo or lithium) for augmenting or enhancing the aroma of consumable materials selected from the group consisting of perfume compositions, perfumed articles, colognes, deodorizing articles, deodorizing compositions and malodor maskants.Type: GrantFiled: October 27, 1993Date of Patent: June 14, 1994Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Matthew J. McGinnis, Leroy P. John, Franc T. Schiet, Charles E. J. Beck
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Patent number: 5292971Abstract: Fluorine-substituted vicinal glycols of the formula ##STR1## in which the substituents R.sub.1 to R.sub.4, independently of one another, have the following meanings: R.sub.1 to R.sub.4 =H, fluorine, C.sub.1 - to C.sub.18 -alkyl in which some or all of the hydrogens may be substituted by fluorine, and at least one of the substituents R.sub.1 to R.sub.4 is a completely fluorinated alkyl or an alkyl of the formula--(CH.sub.2).sub.m --(C.sub.n F.sub.2n+1),in which m is 1 or 2, and n is an integer from 1 to 17, and x is 0 or 1.Furthermore, a method for the preparation of the fluorinated vicinal glycols is described. If the fluorinated vicinal glycols are condensed together with dicarboxylic acids, products having enhanced thermal stability are obtained.Type: GrantFiled: February 12, 1993Date of Patent: March 8, 1994Assignee: Hoechst AktiengesellschaftInventors: Jurgen Kulpe, Heinz Strutz
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Patent number: 5276176Abstract: Described are alpha, 3,3-trimethyl-1-cyclohexen-1-methanol derivative-containing composition having from about 85 up to about 90% by weight of a compound having the structure: ##STR1## and from about 10 up to about 15% by weight of a compound having the structure: ##STR2## wherein R.sub.1 is hydrogen or methyl and R.sub.2 is hydrogen or acetyl with the proviso that when R.sub.1 is methyl, R.sub.2 is hydrogen; and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles including but not limited to solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles and hair preparations; as well as processes for preparing said alpha, 3,3-trimethyl-1-cyclohexen-1-methanol derivative-containing composition.Type: GrantFiled: January 8, 1993Date of Patent: January 4, 1994Assignee: International Flavors & Fragrances Inc.Inventor: Anthony T. Levorse, Jr.
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Patent number: 5196601Abstract: Disclosed herein is a process for producing an alcohol or an amine by reducing a compound having a formyl, keto, nitro, oxirane, ester, nitrile, amide or halogenated carboxyl group with an alkali metal boro-hydride in the presence of a compound having a hydroxyl group and ether linkage. According to the present invention, a functional group having a great steric hindrance can be reduced, and a corresponding alcohol or amine can efficiently be produced under very mild conditions on an industrial scale.Type: GrantFiled: June 17, 1992Date of Patent: March 23, 1993Assignee: Kao CorporationInventors: Tomohito Kitsuki, Yoshiaki Fujikura
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Patent number: 5175347Abstract: A process for preparing cis-dihydronopol and esters thereof in which corresponding esters of (-)nopol are stereoselectively hydrogenated by heterogeneous hydrogenation in the presence of a platinum, platinum oxide or ruthenium/carbon catalyst, and the resulting cis-dihydronopyl esters optionally may be converted into corresponding alcohols by hydrolysis.Type: GrantFiled: December 2, 1991Date of Patent: December 29, 1992Assignee: Kali-Chemie Pharma GmbHInventors: Walter Heitmann, Uwe Maetzel
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Patent number: 5095155Abstract: Closely boiling diastereomeric isomer alcohols are separated by converting them to esters having disparate boiling points, separating the ester isomers by distillation and saponifying the separate ester isomers to obtain the individual alcohol isomers.Type: GrantFiled: June 7, 1990Date of Patent: March 10, 1992Assignee: Union Camp CorporationInventor: Peter W. D. Mitchell
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Patent number: 4866181Abstract: A process for preparing optically active alcohols by reducing ketones using mono- or diisopinocampheylhaloboranes as reducing agents.Type: GrantFiled: December 17, 1987Date of Patent: September 12, 1989Assignee: Aldrich-Boranes, Inc.Inventor: Herbert C. Brown
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Patent number: 4839340Abstract: The invention provides derivatives of bornane-3-spiro-1'-cyclopentane with woody note scent useful as a base component in perfumery formulations which comprises those having a substituting group selected from a methoxyl, ethoxyl, formyloxyl and acetoxyl groups or two of substituting groups being either a hydroxyl group and a methyl group or a hydroxyl group and an ethyl group at the 2-position synthesized by any of the reactions of borane-3-spiro-1'-cyclopentan-2--ol or bornane-3-spiro-1'-cyclopentan-2-one with any of the reagents selected in accordance with the substituting group(s) to be introduced.The invention also provides perfumery compositions containing the above.Type: GrantFiled: June 29, 1988Date of Patent: June 13, 1989Assignee: Kao CorporationInventors: Yoshiaki Fujikura, Tomohito Kitsuki, Manabu Fujita, Nao Toi
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Patent number: 4795738Abstract: Perfume or fragrance compositions containing arbozol to provide a very fresh, outdoor ocean air, woody and ozony odor with a slight cooling effect. The presence of arbozol in such compositions lifts woody and citrus notes, blends and soften harsh notes while imparting a freshness to such compositions and provides improved fixation properties and is excellent as a musk modifier on evaporation or dry-down and modifier of background notes.Type: GrantFiled: November 3, 1987Date of Patent: January 3, 1989Assignee: Bedoukian Research Inc.Inventor: Robert H. Bedoukian
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Patent number: 4728747Abstract: Novel disubstituted bicyclo[2.2.1]heptanes of the general formula I ##STR1## where R.sup.1 is C.sub.1 -C.sub.3 -alkyl, R.sup.2 is C.sub.1 -C.sub.8 -alkyl or-alkenyl, R.sup.3 and R.sup.4 together are .dbd.O, .dbd.CH--CN, .dbd.CH--CO--OCH.sub.3 or .dbd.CH--CO--OC.sub.2 H.sup.5, or R.sup.3 is hydrogen, --CH.sub.3, --CH.dbd.CH.sub.2 or --C.tbd.CH when R.sup.4 is --OH or --O--CO--CH.sub.3, or R.sup.3 is H when R.sup.4 is --CH.sub.2 --CO--OCH.sub.3, --CH.sub.2 --CO--OC.sub.2 H.sub.5 or --CH.sub.2 --C.tbd.N and one or both of the dashed lines may be a further bond, are obtained by subjecting cyclopentadiene to a Diels-Alder reaction with an unsaturated ketone, this reaction being catalyzed by a Lewis acid, and then subjecting the compound of the formula Ia ##STR2## initially formed to a reduction, a Grignard reaction or a reaction with diethylphosphonoacetonitrile or ethyl phosphonoacetate and NaH.They can be used as scents and/or aromas or as intermediates for scents.Type: GrantFiled: December 30, 1985Date of Patent: March 1, 1988Assignee: Basf AktiengesellschaftInventors: Werner Hoffmann, Lothar Janitschke
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Patent number: 4701542Abstract: A process for the resolution of hemiacetal compounds of the formula ##STR1## wherein A is a hydrocarbon chain containing 1 to 16 groups, the said chain optionally containing at least one heteroatom, at least one unsaturation, the assembly of the group constituting the chain may be a mono- or polycyclic system including a spiro or endosystem and the assembly of chain A and the carbon atoms attached thereto can contain at least one chiral atom or the hemiacetal moiety thereto which can present a chirality due to the dissymetric spatial configuration of the molecule and Y is selected from the group consisting of hydrogen, alkyl of 1 to 18 carbon atoms optionally substituted, --CY.sub.3 ' and the .beta.,.gamma.Type: GrantFiled: March 31, 1986Date of Patent: October 20, 1987Assignee: Roussel UclafInventors: Jean Tessier, Jean-Pierre Demoute
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Patent number: 4693844Abstract: A vinylnorbornyl alcohol of 5- or 6-vinyl-2-hydroxymethylbicyclo[2.2.1]heptane which is represented by the following structural formula: ##STR1## The compound has particular fragrance of a mint-like note partaking of camphor tone.Type: GrantFiled: November 22, 1985Date of Patent: September 15, 1987Assignee: Nippon Petrochemicals Company LimitedInventors: Yoshiharu Inoue, Fumio Tanimoto, Hisao Kitano