Abstract: Novel phosphine and phosphine oxide ligands are prepared using polymeric supports. These compounds can be easily cleaved from the support, and along with the corresponding supported compounds, used as ligands in the preparation of novel, metal-complexed catalysts.
Abstract: The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner.
Type:
Grant
Filed:
February 20, 2003
Date of Patent:
December 9, 2003
Assignee:
BASF Aktiengesellschaft
Inventors:
Christian Wulff, Stefan Orsten, Alfred Oftring
Abstract: Bidentate ligand of formula II,
R1R2M1—R—M2R3R4 (II)
wherein M1 and M2 are independently P, As or Sb; R1, R2, R3 and R4 independently represent tertiary alkyl groups, or R1 and R2 together and/or R3 and R4 together represent an optionally substituted bivalent cycloaliphatic group whereby the two free valencies are linked to M1 or M2, and R represents a bivalent aliphatic bridging group containing from 2 to 6 atoms in the bridge, which is substituted with two or more substituents. A catalyst system comprising:
a) a source of group VIII metal cations;
b) a source of such a bidentate ligand; and
c) a source of anions, and use of such a catalyst system in a process for the carbonylation of optionally substituted ethylenically or acetylenically unsaturated compounds by reaction with carbon monoxide and a coreactant is provided.
Type:
Grant
Filed:
May 17, 2001
Date of Patent:
October 28, 2003
Assignee:
Shell Oil Company
Inventors:
Eit Drent, Michael Rolf Eberhard, Paul Gerard Pringle
Abstract: Novel phosphine and phosphine oxide ligands are prepared using polymeric supports. These compounds can be easily cleaved from the support, and along with the corresponding supported compounds, used as ligands in the preparation of novel, metal-complexed catalysts. The ligands are obtained by combinatorial synthesis. A process for preparing coumarin by contacting salicylaldehyde with an acrylate is also provided.
Abstract: The invention relates to polyurethane materials, cross-linked by silane polycondensation, containing alkoxylsilane functional polyurethanes, alkaline fillers, phosphorous compounds aminosilanes, organometallic compounds and optionally additional auxiliary agents, to a method for their production and to the use thereof.
Type:
Grant
Filed:
November 15, 2001
Date of Patent:
September 30, 2003
Assignee:
Bayer Aktiengesellschaft
Inventors:
Lutz Schmalstieg, Ralf Lemmerz, Ulrich Walter, Alexander Eckhardt
Abstract: Compounds of the formula:
having two double bonds which are activated so that they will take part in a polymerization reaction, the double bonds being sufficiently close together to ensure that cyclopolymerization will preferentially occur. These compounds are used as monomers which preferentially are cyclopolymerized under the influence of ultraviolet or thermal radiation in the production of network polymers, for example coatings or binders.
Type:
Grant
Filed:
January 17, 2001
Date of Patent:
August 19, 2003
Assignee:
Qinetiq Limited
Inventors:
Paul E Milne, Keith M Blackwood, Steven M Kelly, Alan W Hall, John W Goodby
Abstract: The present invention provides a novel bisphosphine compound having a chiral center on the phosphorus atom, which is suitable as a ligand for an asymmetric catalyst for use in asymmetric hydrogenation, this bisphosphine compound being represented by the following formula (1):
(where t—C8H17 denotes 1,1,3,3-tetramethylbutyl), and a process for the production of this bisphosphine compound. Also provided are a transition metal complex having this bisphosphine compound as a ligand, and a process for the asymmetric hydrogenation of an unsubstituted carboxylic acid or its ester.
Abstract: Disclosed are compositions from which radically initiated oligomers/polymers having a controlled molecular weight, low polydispersity and a vinyl or dienyl end group are prepared. Further subjects of the invention are a process for controlled radical polymerization, oligomers/polymers obtainable by said process and the use of specific addition fragmentation agents for the polymerization process. The addition fragmentation agents are new in part and these are also subject of the present invention. The addition fragmentation agents are of the formula (Ia), (Ib) or (Ic)
where Y is a group which activates the double bond towards Michael addition.
Type:
Grant
Filed:
February 15, 2001
Date of Patent:
June 10, 2003
Assignee:
Ciba Specialty Chemicals Corporation
Inventors:
Vincent Desobry, Peter Murer, Anne Schuwey
Abstract: Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan.
Type:
Grant
Filed:
August 5, 1999
Date of Patent:
June 3, 2003
Assignee:
Rohm and Haas Company
Inventors:
Tod C. Duvall, Paul B. Adams, Gene K. Norris
Abstract: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
Type:
Grant
Filed:
March 16, 2001
Date of Patent:
May 27, 2003
Assignee:
The Regents of the University of California
Abstract: A process for preparing an ionic liquid or salt, preferably in which the cation comprises an N-alkylated base and the anion is a carboxylate, formed by reaction between an organic base and an alkylating agent, wherein the alkylating agent is a fluorinated ester or an alkyl sulfonate, is described. Suitable organic bases include imizadoles, substituted imidazoles, pyridines and substituted pyridines. The so-formed products can be subsequently transformed into different ionic liquids or salts by metathesis.
Type:
Application
Filed:
September 9, 2002
Publication date:
May 1, 2003
Inventors:
Kenneth R. Seddon, Adrian J Carmichael, Martyn J. Earle
Abstract: Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan.
Type:
Grant
Filed:
August 4, 1999
Date of Patent:
April 15, 2003
Assignee:
Rohm and Haas Company
Inventors:
Tod C. Duvall, Paul B. Adams, Gene K. Norris
Abstract: The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.
Type:
Application
Filed:
July 25, 2002
Publication date:
April 10, 2003
Inventors:
Hector F. DeLuca, Masato Shimizu, Sachiko Yamada
Abstract: The present invention relates to novel complexes of (transition) metals containing ligands having phosphorus centers supporting a carbene atom or heteroalkane radical bonded to the (transition) metal.
Type:
Grant
Filed:
January 26, 2001
Date of Patent:
March 25, 2003
Assignee:
The Governors of the University of Alberta
Inventors:
Ronald G. Cavell, Ruppa P. Kamalesh Babu, Aparna Kasani
Abstract: A pharmaceutically acceptable salt of 2-methyl-3-butenyl-1-pyrophosphoric acid; an agent for treating lymphocytes which comprises at least one of 2-methyl-3-butenyl-1-pyrophosphoric acid, a pharmaceutically acceptable salt thereof, and a hydrate thereof; V&ggr;2V&dgr;2 type T cells treated by the same; and a medicine containing the same specifically stimulate and proliferate the human V&ggr;2V&dgr;2 type T cells, and also induce and enhance an antitumor activity thereof.
Abstract: This invention relates to dendritic macromolecules and their use in metal-dendritic macroligand complex catalyzed processes, e.g., hydroformylation. The use of metal-dendritic macroligand complex catalysts in such processes facilitates the separation of desired product from catalyst, for example, by membrane filtration.
Type:
Grant
Filed:
November 16, 2001
Date of Patent:
February 25, 2003
Assignee:
Union Carbide Chemicals & Plastics Technology
Corporation
Inventors:
Michael Leo Tulchinsky, David James Miller
Abstract: In a method for making bisphosphonates by reacting a carbonyl compound with a phosphorus halide, the reaction is carried out in a solvent/carrier system which is a mixture of an amine hydrochloride, phosphorous acid and optionally phosphoric acid.
Type:
Application
Filed:
June 21, 2002
Publication date:
January 16, 2003
Applicant:
RHODIA CONSUMER SPECIALTIES LIMITED
Inventors:
Justin Mark Cowan, Christopher John Harris, Michael John Harrison
Abstract: Enantiomerically enriched N-acylated &bgr;-amino acids are synthesized by catalytic enantioselective hydrogenation of E-isomers and Z-isomers of 3-amino acrylic acid derivatives in the presence of a catalysts of formula (I)
Abstract: A process for the production of an organic phosphorus-containing product, which comprises reacting a phosphorus-containing oxide with an unsaturated hydrocarbon in the presence of a boron-containing compound at a temperature of less than or equal to 50° C.
Type:
Application
Filed:
May 17, 2002
Publication date:
November 21, 2002
Inventors:
Georges Gros, Michel Garrait, Patrick Rey, Jacques Taillades
Abstract: Organophosphines of the formula (R)aP(H)3−a( where R is C1-C20 alkyl, alkenyl, alkaryl or styryl and a is 1, 2, or 3) are produced by (i) reacting a tris(hydroxyorgano)phosphine (THP) with an organic halogen containing compound; (ii) reacting the product of (i) with a base; (iii) removing aldehydes from the product of (ii) and adding an organic phase, followed by distillation or phase-separation to obtain the desired product.
Type:
Grant
Filed:
June 18, 2001
Date of Patent:
November 5, 2002
Assignee:
Rhodia Consumer Specialties Limited
Inventors:
Gary Woodward, Ranbir Singh Padda, Christian Thomas Regius
Abstract: A novel 2,2-(diaryl)vinylphosphine compound represented by the following general formula (1):
(wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alicyclic group having 5 to 7 carbon atoms, etc.; R2, R3, R4, R5, R6, and R7 may be the same or different and each is an alkyl group having 1 to 6 carbon atoms, an alicyclic group having 5 to 7 carbon atoms, etc., provided that R4 and R5 taken together and/or R6 and R7 taken together may represent a fused benzene ring, a substituted fused benzene ring, a trimethylene group, etc.; and p, q, r, and s each is 0 to 5, provided that p+q and r+s each is in the range of from 0 to 5); a palladium-phosphine catalyst obtained by causing a palladium compound to act on the novel 2,2-(diaryl)vinylphosphine compound; and a process for obtaining an arylamine, a diaryl and an arylalkyne in the presence of the palladium-phosphine catalyst.
Type:
Grant
Filed:
June 27, 2001
Date of Patent:
September 24, 2002
Assignee:
Takasago International Corporation
Inventors:
Ken Suzuki, Tohru Kobayashi, Takenobu Nishikawa, Yoji Hori, Toshimitsu Hagiwara
Abstract: Novel polymer stabilizers are disclosed. The novel stabilizers have the general formula (R)qSn-(MR″-OCH2-R′CH]m-OT)4-q, P-[(OCH2-R′CH)mOT]3′
wherein M is O or S and R″is (CH2)pCO-, CO-(CH3)p, or CO(CH2)p-. About 0.005 to about 65 phr of the stabilizer can be used in a polymer having a halogen-containing repeating unit, such as poly(vinyl chloride), to reduce yellowing of an article made from the polymer after the article has been exposed to gamma radiation.
Abstract: A surfactant comprises a first ionic group comprising at least one hydrocarbon-containing chain; a second ionic group comprising at least one hydrocarbon-containing chain, wherein the second ionic group has a charge opposite to the charge of the first ionic group; and a hydrocarbon spacer group covalently bonded to each of the first and second ionic groups. The surfactant is solubilized in carbon dioxide.
Type:
Application
Filed:
January 24, 2002
Publication date:
September 5, 2002
Inventors:
Joseph M. DeSimone, Jason S. Keiper, Fredric M. Menger, Andrey V. Peresypkin, Caroline J. Clavel
Abstract: The present invention relates to fluoro-&agr;,&ohgr;-bis[(fluoroalkyl)fluorophosphorano)]alkanes, to a process for their preparation, and to their use as intermediates.
Type:
Application
Filed:
February 28, 2002
Publication date:
September 5, 2002
Applicant:
MERCK KGAA
Inventors:
Michael Schmidt, Andreas Kuhner, Nikolai Ignatyev, Peter Sartori
Abstract: Non-chiral and, in particular, optically active alcohols are prepared from a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine in an advantageous manner if a catalyst it used which contains both a support-bonded Ru(II) complex bisphosphine liquid and also a diamine ligand.
Abstract: &pgr;-complex compounds and in particular metallocene compounds of formula (Ia)(Ib),
in which &pgr;I and &pgr;II represent &pgr;-systems, D designates a donor atom and A designates an acceptor atom, D and A being linked by a reversible coordinative bond such that the donor group assumes a positive (partial) charge and the acceptor group assumes a negative (partial) charge, at least one of D and A being part of the associated &pgr;-system in each case, M stands for a transition metal of the 3rd, 4th, 5th or 6th subgroup of the (Mendelian) periodic system of elements, X designates an anion equivalent and n designates the number zero, one, two three or four depending on the charges of M and those of &pgr;I and &pgr;II, are novel and can be used as catalysts for the (co)polymerization of olefins, i-olefins, alkines and/or diolefins or for ring-opening polyaddition.
Type:
Grant
Filed:
October 1, 1999
Date of Patent:
July 23, 2002
Assignee:
Bayer Aktiengesellschaft
Inventors:
Karl-Heinz Aleksander Ostoja Starzewski, Warren Mark Kelly
Abstract: Flexible and semi-rigid vinyl chloride resin compositions comprising a combination of a latent mercaptan and a zinc salt of oxidized polyethylene (a zinc ionomer) as a heat stabilizer are substantially free from the offensive odor typically associated with mercaptans and are protected during processing by the degradation products of the latent mercaptan and the zinc ionomer. The oxidized polyethylene is split out from the ionomer to act as an adhesion promoter for aqueous inks and paints, and the residual zinc carboxylate functions as a co-stabilizer with the latent mercaptan in the composition. The latent mercaptan is exemplified by a 2-S-(tetrahydropyranyl)thioalkanol, a carboxylic acid ester thereof, a 2-S-(tetrahydropyranyl)thiocarboxylic acid, an ester thereof, and the furanyl homologs of each.
Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule incoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
Type:
Grant
Filed:
October 8, 1996
Date of Patent:
April 9, 2002
Assignee:
SmithKline Beecham p.l.c.
Inventors:
Colin Houston Macphee, David Graham Tew, Deirdre Mary Bernadette Hickey
Abstract: Described are bis(perfluoro-n-alkane-sulfonate) compounds, methods for preparing these compounds and use of these compounds, for example as starting materials for the synthesis of chiral and phosphine ligands for transition metal catalysts.
Type:
Grant
Filed:
September 25, 2000
Date of Patent:
March 5, 2002
Assignee:
Merck Patent GmbH
Inventors:
Andreas Wächtler, Karl-Heinz Derwenskus, Andreas Meudt
Abstract: Novel radiopharmaceutical compositions comprising, in combination with a pharmaceutically acceptable carrier, a radioactive salt of pyrophosphoric acid. Also provided are novel radiopharmaceutical compositions comprising, in combination with one or more polymeric resins, a radioactive salt of pyrophosphoric acid. The compositions and matrices are suitable, inter alia, for use in treatment methods involving brachytherapy.
Type:
Grant
Filed:
October 18, 2000
Date of Patent:
February 19, 2002
Assignee:
The DuPont Merck Pharmaceutical Company
Inventors:
Jorge Osvaldo Nicolini, Ricardo Julio Ughetti
Abstract: Disclosed are compounds useful as catalyst activators for olefin polymerization, comprising structures of the following formulae:
wherein:
L+ is a protonated derivative of an element of Group 15 of the Periodic Table of the Elements, additionally bearing two hydrocarbyl substituents of from 1 to 50 carbons each, or a positively charged derivative of an element of Group 14 of the Periodic Table of the Elements, said Group 14 element being substituted with three hydrocarbyl substituents of from 1 to 50 carbons each;
R1 is a divalent linking group of from 1 to 40 non-hydrogen atoms;
R2 independently each occurrence is a ligand group of from 1 to 50 nonhydrogen atoms with the proviso that in a sufficient number of occurrences to balance charge in the compound, R2 is L+—R1—;
M1 is boron, aluminum or gallium;
Arf independently each occurrence is a monovalent, fluorinated organic group containing from 6 to 100 non-hydrogen atoms;
Y is a Group 15 element; and
Z is a Grou
Type:
Grant
Filed:
December 6, 1999
Date of Patent:
February 5, 2002
Assignee:
The Dow Chemical Company
Inventors:
Edmund M. Carnahan, Grant B. Jacobsen, Jerzy Klosin, Peter N. Nickias, David J. Schwartz, David R. Neithamer
Abstract: A method of preparing a compound (I) of general formula (R3—C)2P—L1—X—L2—P—(C—R3)2, in which R is independently a pendant, optionally substituted, organic group through which the group is linked to tertiary carbon atoms C; L1 and L2 are independently, a linking group selected from an optionally substituted lower alkylene chain connecting the respective phosphorous atom to the group X, and X is a bridging group comprising an optionally substituted aryl moiety to which the phosphorous atoms are linked on available adjacent carbon atoms; comprising: (i) reacting together a compound (II) of formula A—L1—X—L2—A, in which A is a halogen atom, with a metal M in a suitable solvent or form an intermediate compound (III) of formula: A—M—L1—X—L2—M—A; (ii) reacting said intermediate compound (III) with a compound (IV) of formula: (R3—C)2P—A1, wherein A1 is a halogen atom which may be the same as or different
Type:
Grant
Filed:
April 13, 2000
Date of Patent:
January 1, 2002
Assignee:
Ineos Acrylics UK Limited
Inventors:
Graham Ronald Eastham, Jamie Michael Thorpe, Robert Paul Tooze
Abstract: A process for the preparation of the formula
Ar13−xP[(Ar2(OZ)y]x I
wherein Ar1 and Ar2 are individually aromatic of 6 to 20 carbon atoms or heteroaromatic of 4 to 9 carbon atoms, each unsubstituted or substituted with at least one member of the group consisting of halogen, carboxyl, —OH, alkyl of 1 to 6 carbon atoms, phenyl and naphthyl, Ar1 has one valence and R2 has y+1 valences, x is an integer of 1, 2 or 3, y is 1 or 2, Z is carbohydrate with a glycosidic bond comprising reacting a hydrocarbon halide of the formula
Z′—X II
when Z′ has the definition of Z with —OH protected and X is chlorine, bromine or fluorine with a phosphane of the formula
Ar13−xP[(Ar2 (OH)y]x III
in a multi-phase reaction medium in the presence of a base and a phase transfer catalyst to form a phosphane of the formula
Ar13−xP[(Ar2(OZ1)y]x IV
and removal of the protective groups to form a compound of Fo
Type:
Grant
Filed:
June 23, 1999
Date of Patent:
May 1, 2001
Assignee:
Celanese GmbH
Inventors:
Sandra Bogdanovic, Matthias Beller, Alexander Zapf, Jurgen Krauter
Abstract: Substituted sodium salts of phosphides are prepared by reacting a triarylphosphine with sodium in an aliphatic amine or diamine as a solvent or co-solvent. The resultant phosphides may be further treated with appropriate halides to produce unsymmetrical phosphines.
Type:
Grant
Filed:
January 11, 2000
Date of Patent:
April 10, 2001
Assignee:
Great Lakes (UK) Limited
Inventors:
Robert Gandy, Peter John Cremins, Allan William Timms
Abstract: A method for manufacturing (3S,4R)-4-[(R)-1′-formylethyl]azetidin-2-one derivatives represented by formula (3) wherein R1 represents a hydrogen atom or a protective group, through asymmetric hydroformylation of 4-vinylazetidin-2-one represented by formula (1) wherein R1 has the same meaning as described above; in the presence of a rhodium complex and a (2S,4S)-diphosphine compound represented by formula (2) wherein R2 represents a phenyl group which may be substituted with 1-5 substituent(s) selected from a lower alkyl group, a lower alkoxy group, and a halogen atom.
By use of both an inexpensive optically active diphosphine compound and a rhodium complex as catalysts, intermediate compounds important for carbapenem antibiotics can be manufactured with high selectivity and efficiency.
Type:
Grant
Filed:
June 10, 1999
Date of Patent:
January 2, 2001
Assignee:
Takasago International Corporation
Inventors:
Howard Alper, Takao Saito, Takashi Miura
Abstract: The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorus bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.
Abstract: Process for converting a geminally substituted cyclopentadiene containing 2-6 substituents into a non-geminally substituted cyclopentadiene by reacting the geminally substituted cyclopentadiene with a base, sodium or potassium at a temperature of 0-200.degree. C. The invention also relates to mixtures of non-geminally substituted cyclopentadienes obtained by means of this process.
Type:
Grant
Filed:
March 3, 1999
Date of Patent:
October 24, 2000
Assignee:
DSM N.V.
Inventors:
Gerardus J. M. Gruter, Johannes A. M. van Beek
Abstract: A purified alkoxide from which volatile impurities causing polymerization and degradation of the alkoxide are removed to extremely low concentrations. The purified alkoxide can be obtained by distilling a crude alkoxide and stripping the distilled liquid alkoxide by applying ultrasonic vibration while passing an inert gas through the liquid alkoxide. A high quality thin insulating film excellent in flatness with few defects such as voids can be obtained by using the purified alkoxide of the present invention as a CVD material.
Abstract: A process for producing a secondary phosphine of formula (2) ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represent an alkyl group, a cycloalkyl group or an aryl group, each of the above groups being optionally substituted by an alkyl group, an alkoxy group, a halogen atom, a perfluoroalkyl group, an amino group or a phosphino group, which comprises reacting a phosphine halide of formula (1) ##STR2## wherein R.sup.1 and R.sup.2 are as defined above and X represents a halogen atom, with a metal selected from the metals of Groups 2 to 15 in the Periodic Table or an alloy thereof and reacting the resultant metal di-substituted phosphide with an agent for protonation.
Abstract: A new compound tertiarybutylbis-(dimethylamino)phosphine and a process for preparing the compound, which has the formula ((CH.sub.3).sub.3 C) ((CH.sub.3).sub.2 N).sub.2 P. The process has the steps of: (1) reacting phosphorus trihalide, PX.sub.3, with tertiarybutyl Grignard reagent, ((CH.sub.3).sub.3 C)MgX, where X is a halide; (2) treating the resulting product with lithium dimethylamide, LiN(CH.sub.3).sub.2 to form a reaction mixture; and (3) recovering ((CH.sub.3).sub.3 C) ((CH.sub.3).sub.2 N).sub.2 P from the reaction mixture.
Type:
Grant
Filed:
February 10, 1997
Date of Patent:
May 9, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Inventors:
Robert W. Gedridge, Jr., Thomas J. Groshens, Kelvin T. Higa
Abstract: A highly pure monoalkylphosphine which is useful as a starting material for producing a compound semiconductor, and a method for producing same in high yield are provided. The highly pure monoalkylphosphine is represented by the general formula RPH.sub.2 (wherein R is an alkyl group having 1 to 8 carbon atoms), has a purity of not less than 99.999%, and is substantially free of sulfur and silica. In the method of producing said highly pure monoalkylphosphine, anhydrous hydrofluoric acid is used as a catalyst for a reaction between phosphine and an alkene, and the reaction is carried out in the presence of an organic solvent having a boiling point higher than that of the resulting monoalkylphosphine; the resulting reaction mixture is contacted with an alkali solution so that the remaining catalyst is removed into an aqueous phase in the form of a fluoride salt; next, the obtained reaction mixture is contacted with an alkali hydride and the impurities are removed, then distillation is carried out.
Type:
Grant
Filed:
December 21, 1998
Date of Patent:
February 15, 2000
Assignees:
Nippon Chemical Industrial Co., Ltd., Shin-Etsu Chemical Co., Ltd.
Abstract: Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.
Abstract: A chromogenic receptor comprises a self-assembled chromogenic compound having at least one intrinsic binding site. The chromogenic compound is characterized by the property of producing a reversible color change responsive to binding a target substrate to the receptor. The chromogenic compound has a transition metal ion and at least one ligand bound to the transition metal ion. The ligand is selected from the group consisting of substituted phenanthroline, substituted 2,2'-bipyridine and substituted 2,2':6',2"-terpyridine. The transition metal is selected from the group consisting of Cu(I), Cu(II), Ag(I), Ni(II), Fe(II), Fe(III), Ru(II), Co(III), and Os(II). Self-assembly can be effected in the presence of Cu(I) to form receptors for dicarboxylic acids, carbohydrate, amino acids, steroids and pyrophosphates. The receptors are characterized by the formation of a 2:1 complex of the target substrate with the receptor producing a visible color change from orange to red and a measurable change in its luminescence.
Type:
Grant
Filed:
December 30, 1994
Date of Patent:
December 7, 1999
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education
Abstract: A process for the purification of crude neomenthyldiphenylphosphine, the process comprising crystallizing the crude neomenthyldiphenylphosphine using a solvent consisting essentially of methanol. The process provides for the unexpectedly efficient production of neomenthyldiphenylphosphine having purities of at least 97 mole percent, and more preferably at least about 99 mole percent. Another embodiment of the invention is neomenthyldiphenylphosphine having a purity of at least 97 mole percent produced by crystallizing crude neomenthyldiphenylphosphine having a purity of less than 97 mole percent using a solvent consisting essentially of methanol.
Type:
Grant
Filed:
May 26, 1998
Date of Patent:
November 30, 1999
Assignee:
Albemarle Corporation
Inventors:
Tse-Chong Wu, K. Pushpananda A. Senaratne
Abstract: A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to covalently bond the first molecule with the second molecule through an aminomethyl phosphorus linkage and the conjugates formed thereby.
Type:
Grant
Filed:
March 14, 1997
Date of Patent:
September 7, 1999
Assignee:
The Curators of the University of Missouri
Inventors:
Kattesh V. Katti, Douglas E. Berning, Wynn A. Volkert, Alan R. Ketring, Robert Churchill
Abstract: The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for completing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
Type:
Grant
Filed:
December 14, 1990
Date of Patent:
June 1, 1999
Assignee:
Mallinckrodt Inc.
Inventors:
Raghavan Rajagopalan, William L. Neumann, Dennis L. Nosco