Abstract: Example apparatus and methods cause activation of target neural tissue through electrical stimulation of a connected white matter tract to reduce the hyper-excitability of the target neural tissue and thus reduce seizures while preserving memory in humans. Example apparatus and methods apply low frequency (e.g., <10 HZ) electrical stimulation to the forno-dorso-commissure (FDC), detect an electrical signal generated in an area connected to, innervated by, or that can be activated by the FDC in response to the stimulation, and reconfigure the stimulation based on the detected signal and a desired therapeutic effect. The stimulation may be reconfigured to produce an electrical stimulation waveform that will produce the desired therapeutic effect. The desired therapeutic effect may be, for example, reducing hyper-excitability of neural tissue in a target area, reducing hippocampal spikes, reducing seizure odds, or improving recall.

Abstract: A biological measurement apparatus of this invention includes (i) a micro piezoelectric element for vibrating a nerve cell of a subject without coming in contact with the nerve cell, (ii) an electromagnetic wave antenna for receiving an electromagnetic wave generated by the nerve cell vibrated by the micro piezoelectric element, and (iii) a computer for measuring an electric charge of the nerve cell based on the electromagnetic wave received by the electromagnetic wave antenna. Further, this biological measurement apparatus includes an electromagnetic wave antenna for emitting an electromagnetic wave to a nerve cell. This configuration provides an apparatus capable of measuring an electrical activity of a nerve cell in a living organism in real time and three-dimensionally at a spatial resolution of a nerve cell size. Moreover, this configuration provides an apparatus capable of individually giving electrical stimulations to any desired cells in the subject.

Abstract: Presented herein are tissue-stimulating prostheses that deliver magnetic stimulation to a recipient. The magnetic stimulation is delivered to the nerve cells through the use of one or more implantable magnetic stimulation coils, such as stimulation coils and/or extra-cochlear stimulation coils.

Abstract: The embodiments herein provide a system and method for detecting, actively targeting and selectively treating the biological targets in a human body by a non-invasive procedure. The system comprises an electromagnetic inductor supported at a predetermined height and rotated to generate a high frequency magnetic field. A head rest is provided at one end of a non-metallic bed provided at the center of the inductor for supporting a patient. A track is arranged below the bed to move the bed and the patient to a desired position indicated by a laser beam to efficiently aim at the targets. The electromagnetic inductor produces electric, magnetic and thermal effects on the nano-conductors attached to the biological targets to activate a nano drug infused into the blood stream of a patient and attached to the surface of the targets to dysfunction or destroy the targets.

Abstract: A proximity sensor for a transcranial magnetic stimulation (TMS) system detects the proximity of a TMS coil assembly to a position at which the coil is to receive pulses during TMS treatment and provides feedback to the operator so that the operator may adjust the TMS coil assembly to maintain optimal positioning during treatment. A flexible substrate containing a sensor or sensor array is disposed between the TMS coil assembly and the position such that the coupling of the TMS coil assembly to the position may be detected by the sensor(s). Sensor outputs are processed by signal processing circuitry to provide an indication of whether the TMS coil assembly is properly disposed with respect to the position during TMS treatment. A display provides an indication of how to adjust the TMS coil assembly to improve the positioning of the TMS coil assembly.

Abstract: Apparatus and methods for delivering electromagnetic signals configured specifically to accelerate the asymmetrical kinetics of the binding of intracellular ions to their respective intracellular buffers, to enhance the biochemical signaling pathways plant animal and human molecules, cells, tissues, organs, portions of entire organisms and entire organisms employ for growth, repair and maintenance. Described herein are devices and methods that utilize repetitive bursts of waveforms configured to maximize the bound concentration of intracellular ions at their associated molecular buffers to enhance the biochemical signaling pathways living systems employ for growth, repair and maintenance. For example the systems and methods described herein may drive the binding of calcium to calmodulin (CaM), thereby enhancing the CaM-dependent nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway.

Abstract: Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.

Abstract: Methods and devices producing time varying magnetic field have therapeutic uses. The device contains a coil made of insulated wires, an energy storage device, an energy source and a switch. The coil is flexibly attached in a case. The device has at least one blower for cooling the coil. The methods and devices can be used in for example in physiotherapy, neuropsychiatric therapy, aesthetic therapy, urology or urogynecology.

Abstract: An energy emitting apparatus for providing a medical therapy includes one or more energy generators, a logic controller connected to the one or more energy generators, and optionally one or more sensors that are connected to the logic controller for detecting muscle stimulation or electric conduction in a target nerve. The energy generators produce energy focused on the target nerve upon receiving a signal from the logic controller, and the energy can be varied by the logic controller according to an input provided by the one or more sensors. In certain embodiments, the energy emitting apparatus includes one or more conductive coils that produce a magnetic field focused on the target nerve upon receiving an electric current. In certain embodiments, a variety of cooling mechanisms or systems may be implemented for cooling the coil.

Abstract: Methods and devices producing time varying magnetic field have therapeutic uses. The device contains a coil made of insulated wires, an energy storage device, an energy source and a switch. The coil is flexibly attached in a case. The device has at least one blower for cooling the coil. The methods and devices can be used in for example in physiotherapy, neuropsychiatric therapy, aesthetic therapy, urology or urogynecology.

Abstract: There is provided a hearing assistance system comprising an auditory prosthesis device for neural stimulation of a patient's hearing at one of the patient's ears and a hearing aid for acoustic stimulation of the patient's hearing at the same one or the other one of the patient's ears. The system includes at least one microphone for capturing an input audio signal from ambient sound; and a fundamental frequency estimation unit for estimating the fundamental frequency and at least part of its harmonics at least for voiced segments of the input audio signal and for supplying a corresponding output signal.

Abstract: Systems, methods, and devices relating to transcranial magnetic stimulation (TMS). A circuit having at least two inductors is used in a TMS device. A small inductor adjacent to the patient's head and a large inductor away from the patient is used. The inductors are coupled to the circuit using multiple semiconductor switching subsystems. The subsystems, when activated, couple the inductors to the circuit and the inductors act as a single inductance. When deactivated, the subsystems decouple the inductors from the circuit and each inductor individually recovers or dissipates/discharges energy stored within. Since each inductor dissipates energy separately from each other, a much shorter dissipation or recovery time is achieved in the inductor close to the patient's brain as compared to the larger inductor. While dissipating or discharging, the small inductor induces electric currents in the brain to thus achieve stimulation and elicit action potentials.

Abstract: A method, apparatus and a system for thermally-assisted pulsed electromagnetic field stimulation for treatment of osteoarthritis are disclosed. In one embodiment, the system comprises a multi-coil applicator adapted for positioning near or around of the treated joint, a pulse generator functionally coupled to the applicator, a power supply, and a feedback loop for stabilizing the temperature of the joint. The feedback loop includes a heating element, a temperature sensor and an electronic controller for maintaining the temperature of the joint in the range of 38 to 42 degree C. At elevated temperatures the healing effect of PEMF stimulation on the cartilage is maximized and overall efficiency of the treatment is improved. To produce a high electric field, the coils of the applicator are made with a low number of turns, for example less than 5 turns, and are spatially arranged to cover the whole joint without “dead” zones.

Abstract: Described herein are methods of treating neurological injury and conditions, in particular symptoms and complications arising from or caused by a stroke. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.

Abstract: Embodiments of the invention include methods of treating neurological injury and conditions, in particular, traumatic brain injury and physiological responses arising from injury or conditions. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field 1 in proximity to a target region affected by the neurological injury or condition to reduce a physiological response to the neurological injury or condition.

Abstract: Described herein are methods of treating neurological injury and conditions, in particular neurological pain. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.

Abstract: An implant device for stimulating osteogenesis and osseointegration comprises a hollow annular housing member, a pulsed current modulator, and a coil connected to the current modulator. The current modulator and at least a portion of the coil are mounted within the housing member. A frequency of the pulsed current is selected to generate an electromagnetic field of a predetermined flux density that penetrates, and propagates radially outwardly from, the housing member for a sufficiently large propagation distance to stimulate osteogenesis and osseointegration, by means of the generated electromagnetic field, of a bone region in which the implant device is implanted and which is disposed radially outwardly from the housing member.

Abstract: An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source.

Abstract: Repetitive Transcranial Magnetic Stimulation (rTMS) is administered at a pulse rate that is equal to or a harmonic of a biological metric of a patient. The purpose is to provide frequency coupling among different organs (e.g., heart, brain, breathing, and gastrointestinal movement) through rhythmic entrainment. The specific harmonic chosen is the one closest to a desired EEG frequency. The desired EEG frequency is chosen based on the cognitive element or symptom that is targeted.

Abstract: Stimulation of the facial nerve system (e.g., electrically, electromagnetically, etc.) in ischemic stroke patients will cause dilation of occluded arteries and dilation of surrounding arteries, allowing for blood flow to circumvent the obstruction and reach previously-deprived tissue. The device approaches the facial nerve and its branches in the vicinity of the ear. In use, the device can be inserted into the ear canal and/or placed in proximity to the ear in order to stimulate the facial nerve system non-invasively (e.g., using an electromagnetic field). The device can be used in the emergency treatment of acute stroke or chronically variations for long-term maintenance of blood flow to the brain and stroke prevention. Additional embodiments of the device may be adapted for use on different regions of the body.

Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic agents or compositions thereof to patients in need of such treatment are also disclosed.

Abstract: Disclosed are apparatus and methods for computer-aided, robotic delivery of transcranial magnetic stimulation (TMS) using biologically derived feedback to establish coil position relative to brain functional regions. The apparatus includes a TMS coil mounted to a robotic member. The position of the stimulating coil can be automatically optimized using the TMS-induced bio-responses of various types.

Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.

Abstract: Devices, systems and instructing methods for treating medical conditions in patients include a handheld non-invasive nerve stimulation device. The device includes a container filled with electrically conductive fluid and one or more energy transmitters surrounded by the conductive fluid. The container comprises a contact surface configured for contacting the outer skin surface of a neck of a patient for delivering electrical impulses from the energy transmitters through the conductive fluid and the patient's neck to the vagus nerve. The electrical impulses are sufficient to treat the medical condition of the patient.

Abstract: A visualization surface representative of a portion of the brain at a depth below the head surface of the subject is generated by combining an actual representation of the head surface with an idealized representation of the head surface. The combining is a function of the depth and is performed to minimize in the visualization surface any irregularities existing in the actual head surface of the subject. A display shows the visualization surface overlaid on a volumetric image of the brain, the electric field induced on a region of the visualization surface by a transcranial magnetic stimulation (“TMS”) induction coil device positioned above the head surface and the TMS coil device. By viewing the display, a user of the TMS coil device can interactively position the TMS coil device in relation to the head surface and, for a target site on the brain at a selected depth, determine the position at which the TMS coil device induces a maximum E-field on a visualization surface corresponding to the selected depth.

Abstract: The invention relates to a device for magnetic field therapy which is preferably adapted for producing nuclear magnetic resonances in the tissue to be treated. The device comprises a base and two side parts having coils integrated therein.

Abstract: This disclosure describes a Wearable Magnetic Stimulator to treat a variety of disorders. The device comprises a wearable stimulator head and a wearable stimulator controller. The patient wears the stimulator head over skin close to the target nerves and carries the wearable controller in his clothing. The wearable head comprises a small gapped cut-core energized by coil windings. The head operates on the principle that its small gap injects fringe flux into target nerves, which induces ionic currents that cure disorders. Small gapped cores require significantly smaller current than large gapped cores. This greatly reduces the size and weight of the head and controller. The wearable controller, such as a cell phone, comprises pulse generator hardware and software from internet. The wearable stimulator can be used to treat several disorders such as migraine headache, arthritis, incontinence, depression, erectile dysfunction etc.

Abstract: Methods and devices are provided for OA treatment of an affected area or joint. In one embodiment, the method may involve identifying a treatment site of the joint, and providing at least one transducer module at the treatment site. The at least one transducer module may be in operative communication with a signal generator module, and may include transducer(s) for delivering stimulative signals (e.g., electromagnetic signals and/or ultrasound signals). The method may also involve stimulating (a) bone remodeling, (b) bone cells and associated precursors, and/or (c) pericytes with the stimulative signals delivered to the treatment site.

Abstract: Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.

Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.

Abstract: An electrical system including one or more bodies having an underlying structure resembling a double helix may be used, together with one or more flexible and transparent fibers that transmit electromagnetic radiation, to produce useful electromagnetic effects for various applications, including therapy. A flexible and transparent fiber may be a fiberoptic cable.

Abstract: An electrical system including one or more bodies having an underlying structure resembling a double helix may be used to produce useful electromagnetic effects for various applications, including therapy.

Abstract: Effective systems and methods for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part including a first signal-providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part, a second signal-providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area, a substantially DC signal-providing component configured to provide direct current spinal stimulation signal at a neural spinal junction and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal.

Abstract: A device for non-invasive treatment of a disorder in a patient comprising a magnetic portion having a first side and a second side, a first metal portion having a first end and a second end, and a second metal portion configured for hand holding and having a first side and a second side, wherein second side of the second metal portion: (i) is coupled to the first side of the magnetic portion; and (ii) has a surface area that is less than the surface area of the first side of the magnetic portion; and wherein the first metal portion is coupled to the second side of the magnetic portion. The first metal portion is optionally fitted with a head. The disclosure further relates to non-invasive methods for treating a disorder in a patient, wherein said methods use said magnetic device.

Abstract: Energy emitting systems are provided which include an adjustable conductive coil configured to generate a magnetic or electromagnetic field focused on a target nerve. The coil includes a central aperture which may be adjustable between a first configuration and a second configuration having a radius greater than the radius of the first configuration. The adjustable or movable nature of the coil allows the conductive coil to conform to, accommodate, or be positioned on a particular anatomical structure of a patient to position the coil in proximity to the underlying target nerve. In certain embodiments, methods of magnetic induction therapy are provided which include positioning a conductive coil relative to a portion of a patient's body by adjusting the central aperture of the coil such that the coil may conform to, accommodate or be positioned on the portion of the patient's body in proximity to the underlying target nerve.

Abstract: A visualization surface representative of a portion of the brain at a depth below the head surface of the subject is generated by combining an actual representation of the head surface with an idealized representation of the head surface. The combining is a function of the depth and is performed to minimize in the visualization surface any irregularities existing in the actual head surface of the subject. A display shows the visualization surface overlaid on a volumetric image of the brain, the electric field induced on a region of the visualization surface by a transcranial magnetic stimulation (“TMS”) induction coil device positioned above the head surface and the TMS coil device. By viewing the display, a user of the TMS coil device can interactively position the TMS coil device in relation to the head surface and, for a target site on the brain at a selected depth, determine the position at which the TMS coil device induces a maximum E-field on a visualization surface corresponding to the selected depth.

Abstract: A medical device includes an orthopedic fixation device and an electromagnetic field emitter carried by the fixation device. The device preferably further includes a power source for powering the electromagnetic field emitter, which may be implanted in the human body with the fixation device and the electromagnetic field emitter. The power source may be a battery.

Abstract: A medical device includes a substrate, a magnetic field emitter disposed on a side of the substrate, and an adhesive on the side of the substrate opposite the emitter.

Abstract: An electrical system having an underlying structure resembling the double helix most commonly associated with DNA is used to produce useful electromagnetic fields for health applications and/or medical applications.

Abstract: Methods, devices and systems for Transcranial Magnetic Stimulation (TMS) are provided for synchronous, asynchronous, or independent triggering the firing multiple of electromagnets from either a single power source or multiple energy sources. These methods are particularly useful for stimulation of deep (e.g., sub-cortical) brain regions, or for stimulation of multiple brain regions, since controlled magnetic pulses reaching the deep target location may combine to form a patterned pulse train that activates the desired volume of target tissue. Furthermore, the methods, devices and systems described herein may be used to control the rate of firing of action potentials in one or more brain regions, such as slow or fast rate rTMS. For example, described herein are multiple electromagnetic stimulation sources, each of which are activated independently to create a cumulative effect at the intersections of the electromagnetic stimulation trajectories, typically by means of a computerized calculation.

Abstract: Embodiments of the disclosed technology provide a combination electroencephalography and non-invasive stimulation devices. Upon measuring an electrical anomaly in a region of a brain, various non-invasive stimulation techniques are utilized to correct neural activity. Stimulation techniques include transcranial direct current stimulation, transcranial alternating current stimulation and transcranial random noise stimulation, low threshold transcranial magnetic stimulation and repetitive transcranial magnet stimulation. Devices of the disclosed technology may utilize visual, balance, auditory, and other stimuli to test the subject, analyze necessary brain stimulations, and administer stimulation to the brain.

Abstract: A transcranial magnetic stimulation system has a magnetic field generating means for generating a variable magnetic field to be used for providing magnetic stimulation to a specific part of the patient's head. The system also has a holder for holding a magnetic coil of the magnetic field generating means, cameras for recognizing respective reference markings or specific portions of ears of the patient (tragi), and laser beam oscillators. According to the system, the coil is set in a proper posture with respect to the specific part of the patient by aligning the optical axes of the cameras and the laser beam oscillators with respective tragi.

Abstract: An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.

Abstract: Described herein are magnetic neural stimulation systems for the treatment of neurological disorders. One variation of a magnetic neural stimulation system includes magnetic stimulators shaped as helical or ramped coils, where each turn of the coil has an acute turning angle of less than 90 degrees. Also described herein are magnetic neural stimulation systems that include an array of stimulators and one or more shielding components. The shielding components modulate the density profile of the induced eddy currents to increase stimulation to targeted neural tissue regions while decreasing stimulation to non-targeted neural regions. Other variations of magnetic stimulation systems include one or more stimulators and a shield in which some of the induced eddy currents in the shield may act to attenuate the magnetic field in certain regions of the shield.

Abstract: A neurostimulation patch is affixed to a patient's skin (e.g., via a medical skin adhesive) and provides stimulation energy for an implanted lead. The patch may be used for SCS trials or other applications where is it desirable to avoid implanting a stimulation device within a patient. Circuitry in the patch generates stimulation signals and couples these signals to the implanted lead. The signals may be coupled to the lead via a direct physical connection or via a wireless connection. In some embodiments, the neurostimulation patch is configured in a manner that enables the patch to be placed immediately above the puncture site where an associated percutaneous lead passes through a patient's skin, thereby protecting the puncture site and facilitating secure routing of the lead.

Abstract: An apparatus is provided for stimulating brain neural networks of a subject comprising: at least one transmitter configured to generate an electromagnetic field through the brain neural networks of a subject, at least one brain wave measuring device for detecting subject brain wave frequency, a CPU for processing data concerned with detection of brain wave frequency of a subject, having a database for storing and analyzing natural and affected brain scans, and at least one computer readable medium containing a predetermined protocol for transmission of the electromagnetic wave frequency profiles. The apparatus further provides a resonance effect thereby inducing newly generated brain cells to migrate toward a brain tissue area having the pathology or lesion of interest, and initiating new brain pathways at the brain region of interest.

Abstract: An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source.

Abstract: Stimulation treatments for medical disorders comprise providing stimulation parameters that create partial stimulation signals which combine into vector signals. The individual partial signals may have frequency or temporal content that is unique rather than all being identical. Vector signals may thus be designed with certain advantageous characteristics such as to influence target tissue in an intended manner while partial signals may be designed with other advantageous characteristics such as to avoid producing side effects in adjacent tissue. Roving of stimulation parameters can be designed to influence partial signals, vectors signals, or both. Partial and vector signals may be designed to match or avoid internal/endogenous activity patterns and rhythms of a patient. Methods for choosing, creating and using partial signals are disclosed. Tissue modulation may be accomplished with electrical and/or magnetic stimulation.

Abstract: An electrical system controlled, driven by and/or based on naturally occurring electrophysiological signals in a patient's body is used to produce useful electromagnetic fields for health applications and/or medical applications provided to the patient.

Abstract: An improved apparatus is provided for transcranial magnetic stimulation in a brain of a subject. The apparatus is comprised of: a plurality of coils electrically connected in series to each other; and a single source of current electrically coupled to one of the plurality of coils. Each coil may include one or more windings of similar dimensions although the size of the windings varies between coils. Each of the coils is further dimensioned to stimulate brain tissue at a given distance while minimizing volume of the brain tissue excited by the magnetic field. During operation, the current source injects time varying current into the coils to create a magnetic field which in turn induces electric fields and eddy-currents inside the brain tissue of the subject.