Abstract: A method and apparatus are provided for the intermittent occlusion of a coronary sinus. The method includes occluding the coronary sinus with an occlusion device, continuously measuring the fluid pressure in the occluded coronary sinus and defining measured pressure by use, releasing the occlusion of the coronary sinus as a function of at least one parameter derived from the measured pressure values, introducing a perfusate into the occluded coronary sinus or at least a vein running into the coronary sinus, and controlling an amount of perfusate introduced as a function of the at least one parameter derived from the measured pressure values. The at least one parameter may be a derivative of a fluid pressure curve according to time, and/or a plateau value of the pressure minima, and/or a pressure value of the pressure maxima, of consecutive heartbeats that is computationally estimated from the measured fluid values.

Abstract: Methods for cardiac ventricular restoration include delivering an implantable expandable device into the ventricle via a catheter. The expandable device is anchored either to the wall of the left ventricle or to the inter-ventricular septum and then expanded. When expanded, the device assumes a size and shape which fills the lower portion of the ventricular cavity restoring the normal volume and ellipsoid shape of the remaining portion of the cavity and favorably altering myocardial oxygen demand and wall stress.

Abstract: In order to fully automate the inflation timing and deflation timing of an intra-aortic balloon pump, certain delays intrinsic in the system must be taken into account. A process for calculating these delays includes determining a nominal inflate command time, adding a dither time interval to the nominal inflate command time to obtain an actual inflate time, and determining a deflate command time. An inflation/deflation cycle is then processed in which the intra-aortic balloon pump is inflated at the actual inflate command time and deflated at the deflate command time. Blood pressure data is acquired from the patient during the inflation/deflation cycle, and is then analyzed to determine a realization time at which the effects of inflating the intra-aortic balloon are realized on the blood pressure waveform. From this the total delay time between the actual inflate command time and the realization time can be determined.

Abstract: A drive unit to control the peak pressure of air for the inflation of a left ventricular assist system is disclosed. The control of the peak pressure can address the problem of the “kick” experienced by patients when the peak inflation pressure reaches approximately 200 mm Hg. The peak pressure of the air released for the inflation cycle of the system is reduced either by the reduction of the inner diameter of the interconnect line running from the compression tank to the valve manifold or the use of a multi-valve manifold with independently controlled valves and an electronic controller to selectively open and close the valves of the manifold. Either technique, whether used alone or in combination, reduces the peak pressure of the air released for the inflation cycle to below the levels associated with the “kick,” while still meeting the operating specifications to properly inflate and deflate the system's blood pump.

Abstract: Circulatory assistance is provided in a non-invasive procedure safely and effectively using a microprocessor of an external counter pulsation device programmed to control the actuation of any or all of a plurality of valves, each of which is mounted on and in fluid communication with one of a plurality of individual inflatable bladders disposed in pockets within cuffs encasing the calves, thighs, buttocks, abdomen and/or chest of a person and an optional valve in fluid communication with the person's airway, in any desired sequence or order, toward the heart or toward the feet, either during diastole or systole, at desired inception times during the cardiac cycle, for selected durations and at chosen pressures, for treating a variety of cardiac, non-cardiac and circulatory conditions.

Abstract: The present invention is a cardiac-assist device and technique used to maintain a patient's cardiac output when normal cardiac output is insufficient. Blood is removed from a selected ventricle using an arterial or venous side approach. The use of a right side approach reduces the amount of work required and reduces the number of foreign objects present within the left side of the heart and associated blood transferring conduits. The device of the invention includes a flexible catheter positionable within the patient's body. An external assist mechanism connected to one end of the flexible catheter receives blood from the arterial circulation and includes a pumping membrane. A flexible cannula is connected for reinfusing blood. A control console is provided for alternately supplying vacuum and pressure to the pumping membrane. A synchronizing means varies inflation and deflation in synchrony with the cardiac cycle of a patient.

Abstract: Since disruptive forces can be continuously exerted upon a rotor during a pulsatile flow through a pump with a magnetically mounted rotor (permanent magnets and addition control current coils), it is necessary to adjust position i.e. modify axial rotor position very quickly. The control current should only result in small amounts of losses. According to the invention, the current is pulse-width modulated by the control current coils by means of a set value predetermined by a controller which is arranged downstream from a position sensing system. If the set value is high, it is switched to a higher voltage level and the real value of the position sensing system is stored for a defined period of time, respectively beginning with the switching flank of the control current, and the position sensing system is disconnected during said period of time.

Abstract: Methods and systems of the present invention provide for measurement of various cardiac parameters. Methods generally involve causing a change in volume and/or pressure in a heart chamber, measuring the change, and calculating at least one cardiac parameter based on the change. Systems typically include at least one actuator, at least one sensor, and a catheter or other device for positioning at least partially in a heart chamber. In some embodiments, the system may also include a controller, such as a computer or other processor, an external actuator, an external sensor, and/or an ECG device. Methods and systems of the invention may be used to more accurately diagnose cardiac conditions in order to make more informed treatment decisions.

Abstract: A minimal intrusive cardiac support apparatus is disclosed which requires only one incision into a main blood vessel or heart chamber. The apparatus includes a pair of generally coaxial and slideably arranged cannulae (one inner and one outer) communicatively coupled to a blood pump for providing right-heart and/or left-heart cardiac support during cardiac surgery. Optional balloons may be mounted on the outside of the inner and outer conduits which can be selectively inflated to seal off the sides surrounding vessel or to deliver cooling fluid or medication to the surrounding tissue. Using the apparatus, a method of pumping blood through the body is also disclosed.

Abstract: A pump system includes an implantable pump including a motor having a rotor and a stator. The stator includes a plurality of stator windings, and a motor controller is coupled to the motor to energize the windings so as cause the rotor to turn. A time-based system parameter of the pump is sampled and the system parameter is analyzed to calculate a suction probability index that provides an indication of the imminence of ventricle collapse.

Abstract: An intravascular pump, which may be a left ventricle assist device, comprising a wall defining a pumping chamber, the wall support by struts, the struts attached to or part of an actuation system to move the wall from an expanded position to a contracted position and back to operated the pump, the actuation system may be electrically activated shape memory alloy struts, electroactive polymeric struts, or may be a balloon, struts attached to a slidable member or other suitable system.

Abstract: An apparatus for a heart assist device, comprising a processing unit for computing the blood flow rate from the arterial pressure curve and for predicting at every heartbeat the closing time of the heart valve from the curve of the blood flow rate. The processing unit is adapted to deliver a signal for controlling a heart assist device at a point in time, a period ahead in time of the closing time of the heart valve, wherein the mechanical properties of the said heart assist device are taken into account in determining the period. The apparatus adapts itself to changes in a patient's heart frequency and aortic pressure.

Abstract: A heart assist device, for example a left ventricular assist device (LVAD) including a blood pump, is controlled on the basis of a ratio of the pump's speed and the patient's heart rate. The patient's activity and a required cardiac assist level can be defined via the heart beat rate of the patient and a rotational speed of the LVAD pump. Controlling the pump of the heart assist device based on the pump speed and the patient's heart rate enables the heart assist device to respond to changes in the patient's activity level.

Abstract: The present invention provides methods for detecting an abnormal condition of a blood pump system based on the power consumption of the pump actuator. By plotting differentiated power consumption of the pump actuator over time against the power consumption, a plot pattern is obtained. A change of the plot pattern area and/or a movement of the plot pattern will indicate a change in condition of the pump. A Heart Pump Area (HPA) index may be established which corresponds to the changing area of the plot pattern over time. A Heart Pump Position (HPP) index may be established which corresponds to the changing position of the plot pattern over time (e.g., corresponding to the distance the plot pattern has moved). By plotting the HPA index against the HPP index, changes in the condition of the pump can be monitored and any abnormal condition of the pump can be detected.

Abstract: Method for controlling an assist pump for fluid delivery systems with pulsatile pressure. If for example a heart assist pump is driven with a constant number of revolutions, it is achieved, that the blood is also delivered through the assist pump, even when the heart chamber is in the decontraction phase. With the present method it is achieved, that an assist pump only acts supportingly in the pressure phase of the main pump, in such a way, that the pressure difference between the input side and the output side of the assist pump is continuously determined and the number of revolutions of the assist pump is controlled in such a way, that the determined pressure difference does not fall below a predetermined value and the rate of flow does not sink below zero.

Abstract: A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member. The radially expandable member is located down-stream of the shaft agent delivery port, and has an expanded configuration with an outer diameter larger than an outer diameter of the tubular member.

Abstract: A fluid pump for pumping fluid. The fluid pump includes a driver having a substantially tubular shaped body defining a body axis and, a number of elements circumferentially spaced around the body. Each element is responsive to a signal to so as cause a corresponding portion of the body to expand or contract in a direction substantially parallel to the tube axis. The pump also includes an urging member positioned in a flow path. In use, the urging member is coupled to the driver such that selective expansion and/or contraction of the body causes the urging member to rotate, thereby urging fluid along the flow path.

Abstract: A driver for a pneumatic ventricular assist device (VAD) is powered by pressurized air, oxygen or any other gas commonly available in hospital rooms, intensive care units and operating rooms. The driver can provide both blood-ejecting pressure (systole) and blood-filling vacuum (diastole) to the VAD. The driver is controlled by a computer/digital controller by means of pressure and volume sensors, and electromechanical valves. Ventricular pumping is performed by a single spring-loaded piston or bellows. The computer can actively regulate maximum systolic ventricular pressure, maximum diastolic vacuum, cycling rate and/or ejection volume (depending on the operating mode). The driver is also capable of automatically and periodically venting the drive line to eliminate condensation and foul air. The absence of a motor or electrical pump make the device small, reliable, easy to handle, and less expensive.

Abstract: An external counterpulsation apparatus has an efficient cuff and bladder system. Embodiments of this system generally allow effective treatment at lower pressures and a reduced total body surface area being compressed. An accurate and reliable combination of automatic and preset timing for inflation and deflation of the bladder system is used to simplify use of the apparatus.

Abstract: The invention herein is an enhanced VAD device (EVAD), for a physician to use to restore a dysfunctioning native heart with severe muscular damages to good health, so that the EVAD can be explanted eventually. The EVAD device comprises one or two VAD(s) a pacemaker for sending electrical pulses to the native heart, a first monitor for monitoring the patient's response to each of said electrical pulses from the pacemaker, ccntrolled means a set of attachments for measuring biological and or clinical signals at various organs both inside and outside the patient's body, and a controller for facilitating the physician's work.

Abstract: A blood pumping system to support living organisms based on a spherical multi vane and multi chamber pump with an oscillating motion that delivers pulsatile flow. The blood pumping system includes a number of design elements that address the particular needs and compatibility issues (both biological and hemological) of a blood pumping system.

Abstract: A perfusion system for off-pump coronary artery bypass is provided in order to make the off-pump coronary artery bypass easier and safer and to restrict the amount of bleeding to a degree for not affecting operations by occluding the vessel in concurrency with the perfusion, including a blood removal portion, a pump, and a perfusion portion for returning blood pumped out by the pump in the form of an injection of the blood in pulses in response to a diastolic phase of the heart.

Abstract: A blood pump may be adapted to sense the onset of left ventricular collapse by monitoring a pulsatility index, and may adjust the pump speed to maintain the index at a setpoint. The pulsatility index may be measured by the amount of difference between the maximum and the minimum volume of flow through the pump during a particular time period. The setpoint may be increased when the onset of ventricular collapse is detected, for example, when the pulsatility index falls suddenly. The setpoint may be decreased incrementally when the onset of ventricular collapse has not been detected for a period of time, such as for a particular period of time since the last detection of the onset of ventricular collapse.

Abstract: A blood circulation assistance device (1), for location around a blood conduit (20). The device comprises: an inflatable bladder (10) moveable between a contracted form and an expanded form, for compressing the blood conduit (20) to provide counterpulsation. Pump means (30) in fluid communication with the bladder (10) move the bladder (10) from the contracted form to the expanded form. The pump means (30) comprises a centrifugal impeller (62) rotatable about an axis (61) to effect pumping. The impeller (62) is moveable axially between first and second positions to effect a reversal of the direction of pumping. Control means (50), in communication with the pump means, is capable of monitoring the cardiac cycle of an individual and triggering the pump means (30) to move the bladder (10) to the expanded form at diastole. An outer cuff, surrounds at least a portion of the bladder (10), providing an outer limiting extent to the movement of the bladder (10).

Abstract: The invention is directed to a device for flat illumination of an object field in an optical instrument and to an optical instrument with a device of this kind. Optical instruments of this type are, for example, microscopes, including microlithography simulation microscopes in which a flat illumination, i.e., illumination extending beyond a singular object point, of the object to be examined is required. The device comprises a laser light source and a light-conducting cable with at least one optical fiber through which the light from the laser light source is guided to the object field. The optical fiber is constructed and dimensioned in such a way that the intensity of the illumination light within the cross section of the optical fiber becomes increasingly more uniform along the path from the input-side end to the output-side end, and the illumination light is directed from the output-side end of the optical fiber to the object with substantially homogeneous intensity distribution.

Abstract: A process for assisting the function of a heart disposed within a body, and comprising an outer wall, comprising the steps of measuring at least one parameter that is indicative of the function of the heart, applying a compressive force to a portion of the outer wall of the heart, and applying an expansive force to the portion of the outer wall of the heart. The process is preferably performed with an apparatus comprising a cup-shaped shell having an exterior wall, an interior wall, an apex, and an upper edge; a liner having an outer surface and an inner surface, an upper edge joined to said interior wall of the cup-shaped shell, and a lower edge joined of the interior wall of the cup-shaped shell, thereby forming a cavity between the outer surface thereof and the interior wall of the shell; and a drive fluid cyclically interposed within the cavity, the drive fluid applying a uniform force on a portion of the outer wall of the heart.

Abstract: The present invention relates to therapeutic devices to work in conjunction with a diseased or failing heart to satisfy the hemodynamic needs of a patient. More particularly, the invention relates to a fully implantable device for assisting a heart to pump blood by intermittently applying pressure to at least a portion of the ventricular surface of the heart (if not the entire surface), preferably both the atrial and ventricular surfaces, at predetermined or possibly pre-programmed intervals to assist the heart to provide adequate hemodynamic output by sensing demand of the human body. In short, the present invention assists the maintenance of, or reestablishes, the normal contraction sequence of a healthy heart.

Abstract: A blood pump system includes a blood pump having a motor with a rotor and a stator. The stator has a plurality of stator windings situated therein. A motor controller is coupled to the motor, and a processor has inputs coupled to the motor controller for receiving a time continuous signal from the pump. The processor is programmed to transform the time continuous signal to the frequency domain, and control the pump and detect excess suction in response to the time continuous signal in the frequency domain.

Abstract: A magnetic pellet for use in treating a patient's congestive heart includes a contact portion and a plurality of wings. Each wing has a distal end portion hingedly connected to the contact portion and a proximal end portion. The proximal end portions bend toward each other when an electromagnetic field is applied to the pellet. A method of inserting the pellets into a myocardial wall of a heart includes supplying an electromagnetic field to the pellet attached to a distal end of an electromagnetic rod positioned within a delivery catheter, positioning the magnetic pellet at a target area on the myocardial wall; using an injection syringe, positioned at a proximal end of the catheter, to force the pellet into the myocardial wall; and removing the electromagnetic field previously supplied to the pellet and thereby causing the spring-wings to open.

Abstract: The present invention is directed to a cardiac assist device for assisting with the function of a heart. The assist device includes a compressor positioned adjacent the epicardial wall of the heart. The compressor is driven by one or more electroactive polymer actuators. The pressure exerted against the heart improves heart function.

Abstract: In a left ventricular assist device (LVAD) a rotodynamic blood pump (10) is powered by a brushless DC motor (12). A power supply (14) supplies power to the motor (12). Three feedback channels, one for each of voltage, current, and motor speed lead to a microcontroller or microprocessor (18). The three feedback waveforms are analyzed, and from these waveforms, motor input power, patient heart rate, current pump flow rate, and systemic pressure are determined. The microprocessor (18) then calculates a desired flow rate proportional to the patient heart rate. The microprocessor communicates a new power output to a commutation circuit (16), which regulates power to the mortor (12). The pump (10) also includes safety checks that are prioritized over desired pump flow. These include prevention of ventricular suction, low pulsatility, minimum and maximum pump speed, minimum peed-relative pump flow, minimum absolute pump flow, minimum and maximum motor input power.

Abstract: An apparatus and method for assisting cardiac function of a patient includes a flaccid inflatable chamber held at a predetermined volume generally midway between fully inflated and fully deflated for performing a periodically scheduled patient monitoring routine for measuring values of the physiology of the patient, and reinflating the chamber after either detecting a dicrotic notch or expiration of a measurement time period window, whichever occurs first. A software program is connectible in electronic communication with the control program for adjusting settings of the drive unit. The software program is capable of one or more of the following functions: retrieving current values of physician programmable parameters, selectively retrieving a history of the drive unit operation including error detection records, displaying a continuous ECG, and/or displaying a single-beat sample of aortic pressure waveform obtained in real time from the patient.

Abstract: An apparatus for a heart assist device, comprising a processing unit for computing the blood flow rate from the arterial pressure curve and for predicting at every heartbeat the closing time of the heart valve from the curve of the blood flow rate. The processing unit is adapted to deliver a signal for controlling a heart assist device at a point in time, a period ahead in time of the closing time of the heart valve, wherein the mechanical properties of said heart assist device are taken into account in determining said period. The apparatus adapts itself to changes in a patient's heart frequency and aortic pressure.

Abstract: Methods are provided for conducting diagnostic or therapeutic medical or surgical procedures in a patient wherein, during the procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an atrioventricular (AV) node blocker. In one embodiment, compositions including an AV node blocker and a &bgr;-blocker are provided, wherein the &bgr;-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of techniques, including minimally invasive microsurgical techniques.

Abstract: A dual pusher-plate blood pump implanted into the body with either mechanical or biological valves (17) for unidirectional blood circulation through a circulation variable chamber (blood chamber) (12) to assist circulation. LVAS comprises a receptacle (housing) (4) provided with an inlet (3) and an outlet (5) The pump inflow (3) is connected to the left atrium and the pump outflow to the descending thoracic aorta (5,7) and a pulsating external pneumatic unit (8).

Abstract: A pumping system 10 provides a physiological pulsatile flow and includes controller 121, a pump drive head 50 coupled to a motor 12 and a fluid housing 52 having at least one port 60. The port 60 includes a ball valve retainer region 69, a valve seat 73, and an occluder ball 71 disposed in the ball valve retainer region 69. During operation, the motor 12 forces the fluid in and out the fluid housing 52 and causes the occluder ball 71 to move from a first position whereby the fluid cannot pass through the port 60, to a second position whereby the fluid moves annular to and generally around the occluder ball 71. This movement creates a slight flow reversal that “breaks up” any blood clots that may form. The pumping system may be used as part of a cardiopulmonary bypass system, a ventricular assist device (VAD) and/or a heart pump.

Abstract: Disclosed are systems and methods for performing counter-cardiac retrograde perfusion. Perfusion is performed in a counter-cardiac cycle such that oxygenated blood is urged through a patient vein associated with an organ to be provided with the blood during diastole only.

Abstract: A blood pump is joined in parallel flow between the left ventricle and aorta of a patient's heart. The pump includes an inlet pressure sensor and cooperating controller for measuring inlet pressure to the pump to control operation thereof. The controller adjusts speed of the pump in a closed loop control using feedback of the measured inlet pressure to conform operation of the pump with the natural cycle of the heart.

Abstract: An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. One embodiment of the intravascular extracardiac system comprises a pump with inflow and outflow conduits that are sized and configured to be implantable intravascularly through a non-primary vessel, whereby it may positioned where desired within the patient's vasculature. The system comprises a subcardiac pump that may be driven directly or electromagnetically from within or without the patient. The pump is configured to be operated continuously or in a pulsatile fashion, synchronous with the patient's heart, thereby potentially reducing the afterload of the heart.

Abstract: A method of aiding the compression and relaxation of a heart chamber using ferromagnetic and diamagnetic pellets inserted into the anterior and posterior walls of the chamber is provided. The pellets are inserted into the myocardial walls of the heart chamber by means of a delivery catheter. Electromagnetic fields, which are used to push and pull the pellets to compress and relax the hear chamber, are cyclically generated by electromagnetic field generators positioned on a patient's chest and back wall.

Abstract: The invention adapts the pericardium for use as a pump bladder having a pump cavity formed by at least a portion of the pericardial space between the parietal pericardium and the visceral pericardium. The pump bladder is inflated to provide a compressive pressure on the heart and deflated to relieve the pressure. The pericardium is modified under conditions to improve the pumping characteristics of the pericardium as a pump bladder. A portion of the parietal pericardium may be attached to a portion of the visceral pericardium to isolate a portion of the pericardial space to form the pump cavity. The pericardium may be treated by stiffening, strengthening, tightening, shrinking, reshaping, or reducing the compliance or elasticity of the pericardium, or any combination thereof. The treatment may be carried out by heating the pericardium, applying a chemical to the pericardium, plicating the pericardium, or any combination thereof.

Abstract: A blood circulation assisting device using a continuous flow blood pump (1) for blood feeding assistance to remove blood through a blood removing pipe (2) and drive out blood at a predetermined flow rate through a blood feeding pipe (3). The blood circulation assisting device includes a current measuring unit (7) for measuring current flowing through a motor (4) driving the pump (1) in order to use the current as data corresponding to a blood flow rate through the continuous flow blood pump (1) and an amplitude detection unit (8) for detecting, from an output of the current measuring unit (7), the amplitude of fluctuation of current flowing through the motor (4) in order to use the amplitude as data corresponding to a flow rate amplitude due to flow rate fluctuation. The amplitude of this fluctuation is divided by an average current value and output as an amplitude index.

Abstract: A unified, non-blood contacting, implantable heart assist system surrounds the natural heart and provides circumferential contraction in synchrony with the heart's natural contractions. The pumping unit is composed of adjacent tube pairs arranged along a bias with respect to the axis of the heart and bound in a non-distensible sheath forming a heart wrap. The tube pairs are tapered at both ends such that when they are juxtaposed and deflated they approximately follow the surface of the diastolic myocardium. Inflation of the tube pairs causes the wrap to follow the motion of the myocardial surface during systole. A muscle-driven or electromagnetically powered energy converter inflates the tubes using hydraulic fluid pressure. An implanted electronic controller detects electrical activity in the natural heart, synchronizes pumping activity with this signal, and measures and diagnoses system as well as physiological operating parameters for automated operation.

Abstract: A biventricular cardiac prosthesis has a flow balance control system to balance blood flow through the left and right sides of the prosthesis to maintain a patient's left atrial pressure within physiologic bounds. The prosthesis can be configured to have flow characteristics so that a signal representative of the difference in hydraulic pumping pressures on the left and right sides of the prosthesis is representative of the difference between left and right atrial pressures of a patient having the prosthesis implanted. This signal can be used as a control signal to drive the prosthesis so that left atrial pressure is approximately equal to right atrial pressure, and within physiologic bounds. A specific prosthesis includes left and right pumping sections, each having a blood pumping chamber and a hydraulic fluid chamber, with a reciprocating hydraulic pump driving systole alternately on the right and left sides.

Abstract: An implantable medical device system for detecting cardiac conditions such the long-term ischemic heart disease, an occlusion of a coronary artery by a thrombus or an impending as a myocardial infarction. The implantable medical device (IMD) system includes a sensor that outputs a blood flow rate signal representing a rate of blood flow through a coronary sinus of a patient's heart. An implantable medical device (IMD) includes a microcomputer circuit configured to analyze the blood flow rate signal and detect a cardiac condition as a function of the blood flow rate signal. The system can also includes an implantable lead that senses electrical activity from the patient's heart. The microcomputer circuit monitors an ST segment of the electrical activity signal and detects a cardiac condition as a function of blood flow rate signal in conjunction with the electrical activity signal.

Abstract: A method of diagnosing pulmonary congestion is provided. At least one decrease in a trans-thoracic impedance value from a baseline trans-thoracic impedance value is sensed. At least one increase in a heart rate value from a baseline heart rate value is also sensed. Pulmonary congestion is diagnosed if the decrease in the trans-thoracic impedance value corresponding to the increase in the heart rate does not increase after a predetermined interval. Systems and programs incorporating the method are also provided.

Abstract: An apparatus for assisting cardiac function of a patient includes an inflatable chamber operably positionable with respect to an aorta of the patient, a percutaneous access device implantable with respect to a hypogastric region of the patient and connectible in fluid communication with the inflatable chamber, and a drive unit connectible through the percutaneous access device for selectively inflating and deflating the inflatable chamber in accordance with a control program stored in memory. The control program controls the drive unit in response to a periodically scheduled patient monitoring routine for measuring values of the physiology of the patient. The control program uses measured values as modified in accordance with the control program and physician programmable parameters for assisting cardiac function of the patient.

Abstract: A system for assisting the failing ventricle, which utilizes a single blood displacement chamber and a single cannula. The cannula is inserted into the failing ventricle cavity and is connected to a blood displacement actuator. The device produces blood displacement at a critical time for a critical duration and with blood flow time course such that it improves the systolic function of the heart: augments the cardiac output and increases the generated pressure. The device also improves the diastolic function by increasing the ventricle compliance and imposing rapid relaxation of the ventricle wall. The device provides additional external work without deteriorating the mechanical function of the failing ventricular, moreover it decreases the energy consumption of the failing heart and improves the coronary perfusion. Consequently, the device improves the balance between the energy supply (coronary perfusion) to the ventricle wall and the mechanical demands, and allows recovery of the failing heart.

Abstract: In a means for support of the performance of a heart (1) in which fluid is taken from blood vessels via an external pump (7) and is returned to the blood vessels, the amount of fluid being controlled as a function of the measured values, a catheter in the ventricle is equipped with sensors (4) for measuring the volume of fluid per unit of time. The sensors (4) are connected to an evaluation circuit in which the ratio of the diastolic volume to the systolic volume per heartbeat or unit of time, especially the output rate and/or the deviation of the volume which has been delivered by the heart per unit of time from a defined setpoint, for example the setpoint which has been computed from body-specific data for the cardiac output (HZV), is evaluated and a signal is generated. The pump (7) via which fluid is withdrawn from the ventricle is controlled depending on the generated signal.

Abstract: A network communication and messaging protocol for use in a medical perfusion system, provides the rules which govern how, among other things, information and data is conveyed between the various devices which are connect to the network. The rules define the different types of messages that are used in conveying information and data, as well as the formatting for each of those message types. The various messages provide the ability to configure the perfusion system devices, establish links between the perfusion system devices, and convey various types of information and data, even when the main network controller is unavailable.