Endoradiosonde Patents (Class 600/302)
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Patent number: 8764667Abstract: A method of monitoring sleep of a sleeping subject is disclosed. The method comprises determining a phase shift of input radiofrequency signals received from the subject during sleep relative to output radiofrequency signals transmitted to the subject during sleep, calculating cardiac output based on the phase shift, and using the cardiac output for identifying sleep apnea events.Type: GrantFiled: March 6, 2008Date of Patent: July 1, 2014Assignee: Cheetah Medical, Inc.Inventors: Yoav Avidor, Daniel Burkhoff, Pierre Squara, Hanan Keren
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Publication number: 20140180040Abstract: In a capsule endoscope, on an inside of a capsule type housing including a cylindrical main body section and two semispherical end cover sections and having a rotationally symmetrical shape with respect to a center axis of the housing, an image pickup board section, a transmission board section, and a reception board section are housed such that principal planes of the image pickup board section, the transmission board section, and the reception board section are orthogonal to the center axis. A coil wire of at least one of a transmission coil formed by a transmission coil wire and a reception coil formed by a reception coil wire, respective principal planes of which are orthogonal to the center axis, is disposed on the end cover section side of the housing.Type: ApplicationFiled: February 27, 2014Publication date: June 26, 2014Applicant: OLYMPUS CORPORATIONInventors: Noriyuki FUJIMORI, Takatoshi IGARASHI, Yukiharu MAKINO
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Publication number: 20140155709Abstract: A capsule medical device includes: a power supply unit; a capsule detection magnetic field generation unit configured to generate a capsule detection magnetic field, with which at least one of a position and a posture of the capsule medical device is detected, upon receiving electric power; a state detection unit configured to detect a state of the capsule medical device; a control unit configured to control power supply to the capsule detection magnetic field generation unit; and a magnetic field response unit configured to respond to a guiding-magnetic field for guiding at least one of the position and the posture, wherein the state detection unit includes a guiding-magnetic field detector configured to detect at least one of a strength, a direction, and a gradient of the guiding-magnetic field, and the control unit controls the power supply in accordance with a detection result of the guiding-magnetic field detector.Type: ApplicationFiled: November 21, 2013Publication date: June 5, 2014Applicant: OLYMPUS MEDICAL SYSTEMS CORP.Inventors: Takuto IKAI, Hironao KAWANO, Atsushi CHIBA, Atsushi KIMURA
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Publication number: 20140155710Abstract: A wireless circuit includes a housing, such as a hermetic housing, and at least one antenna coil wound about a coil axis within the housing. The coil axis may be substantially parallel to at least one wall of the housing, wherein the wall parallel to the coil axis is substantially thinner than other walls of the housing.Type: ApplicationFiled: June 29, 2012Publication date: June 5, 2014Inventors: Harry D. Rowland, Michael Nagy
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Patent number: 8738106Abstract: A device for in vivo analysis includes: a reaction chamber to store a detecting reagent able to react with a sample collected in vivo; and optionally a labeled-substance chamber to store a labeled substance able to bind to at least a portion of a compound resulting from a reaction of the detecting reagent and the sample. The in-vivo imaging device, typically an autonomous capsule, may have a housing, the housing comprising a window; an illumination source located within the housing to illuminate a body lumen through the window; an imager to receive light reflected from the body lumen through the window; and a transmitter to transmit image data to a receiving system. The window is coated with liposomes containing a marker such that the imager may acquire images which include the marking.Type: GrantFiled: July 31, 2007Date of Patent: May 27, 2014Assignee: Given Imaging, LtdInventors: Elisha Rabinowitz, Emil-Israel Katz
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Patent number: 8723640Abstract: Configuration technologies for cost-effectively indicating a regimen compliance status of a subject, for example, responsive to whether a presence of a wireless signal in a first frequency range below a threshold frequency occurred contemporaneously with an absence of a wireless signal in a second frequency range above the threshold frequency.Type: GrantFiled: August 16, 2011Date of Patent: May 13, 2014Assignee: Elwha LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Jordin T. Kare, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Publication number: 20140114149Abstract: A lung cancer diagnosing device and the method thereof are provided. Lung cancer is diagnosed by using pulse waves having a wideband pulse width, so a possibility that a patient is exposed to radiation can be reduced, and since the configuration of transmission and reception circuits and relevant hardware of the device are simple, the size of the overall module is reduced. In addition, since lung cancer is diagnosed by observing a difference between time delays of pulse waves received by a reception unit according to positions of a transmission module that transmits pulse waves, while moving along digestive organs, a complicated signal processing procedure is not required, and thus, a time required for imaging lung cancer diagnosis results can be reduced.Type: ApplicationFiled: October 1, 2013Publication date: April 24, 2014Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Se-Yun KIM, Ji-Hyun JUNG, Jae-Hyoung CHO
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Publication number: 20140088379Abstract: Apparatus and methods for the measurement and transmission of data pertaining to the tissue of an animal. In one embodiment, there is an implantable device that is wirelessly powered and also wirelessly transmits data. Preferably, the implant measures neuromuscular activity.Type: ApplicationFiled: July 31, 2013Publication date: March 27, 2014Applicant: Purdue Research FoundationInventors: Pedro Irazoqui, Rebecca Bercich
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Publication number: 20140073884Abstract: Among others, the present invention provides apparatus for detecting circulating tumor cells, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electrical, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, electro-mechanical, electro-chemical, electro-optical, electro-thermal, electro-chemical-mechanical, bio-chemical, bio-mechanical, bio-optical, bio-thermal, bio-physical, bio-electro-mechanical, bio-electro chemical, bio-electro-optical, bio-electro-thermal, bio-mechanical-optical, bio-mechanical thermal, bio-thermal-optical, bio-electro-chemical-optical, bio-electro-mechanical-optical, bio electro-thermal-optical, bio-electro-chemical-mechanical, physical or mechanical property, or a combination thType: ApplicationFiled: May 4, 2012Publication date: March 13, 2014Applicant: ANPAC BIO-MEDICAL SCIENCE CO., LTD.Inventors: Chris C. Yu, Xuedong Du, He Yu
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Publication number: 20140066726Abstract: A biological sample collection device includes a top cover plate, a bottom portion attached to the top cover plate, the bottom portion comprising a remotely-analyzable biological sample collection portion to collect a biological sample from a body of a subject. The biological sample is to be analyzed at a remote processing facility at a later time. A fastening portion is provided on the bottom portion to affix the remotely-analyzable biological sample collection device to the body of the subject. A real time clock is coupled to the top cover plate and a memory is coupled to the top cover plate and electrically coupled to the real time clock. The remotely-analyzable biological sample collection device may further include a processing unit, at least two electrodes coupled to the processing unit, and a transbody conductive communication module.Type: ApplicationFiled: March 8, 2012Publication date: March 6, 2014Applicant: PROTEUS DIGITAL HEALTH, INC.Inventor: Benedict Costello
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Patent number: 8663105Abstract: An ingestible apparatus produces and processes physiological signals representative of a physiological parameter. The apparatus measures the physiological parameter from within the body of a living entity. The apparatus includes a physiological transducer circuit to sense the physiological signals, a processor to process the physiological signals in response to the physiological transducer circuit, and a transmitter that transmits the processed signals during transmission intervals which are alternated with idle intervals. The apparatus further includes a capacitor-based circuit, including at least one capacitor, to accumulate sufficient charge during one of the idle intervals to supply power to the transmitter during one of the transmission intervals.Type: GrantFiled: August 8, 2009Date of Patent: March 4, 2014Assignee: NXP, B.V.Inventors: Jean-Marie Malaurie, Yvan Olivier Jean Ghislain Droinet, Marc-Herve Stodel
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Publication number: 20140058221Abstract: Systems and methods described herein use near field communications to locate a radiating transponder, such as a pill swallowed by a patient. The system can be triggered to turn on and transmit an amplitude shift keyed waveform (or other type of waveform) to a set of antennas attached to, coupled with, or near the patient at roughly known locations. The magnetic field emitted by the transponder can be measured by the receiving antennas, for example, using principles of mutual inductance. The differential phase and/or time shifts between the antennas can contain sufficient information to find the location of the transponder and optionally its orientation relative to body coordinates. The system can display the location and/or orientation of the transponder and may optionally provide other information about the movement, flow, or other characteristics of pill to assist clinicians with diagnosis.Type: ApplicationFiled: August 16, 2013Publication date: February 27, 2014Applicant: Rock West Solutions, Inc.Inventors: Thomas Eugene Old, John Christopher Baker, Neal J. Carron, Donald Gordon Pritchett
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Publication number: 20140051949Abstract: Systems and methods described herein use near field communications to locate a set of antennas attached to, coupled with, or near the patient. A signal emitted by an antenna in the set of antennas can be received by the other antennas in the set. A second signal can be further transmitted from another antenna in the set. The differential phase and/or time shifts between the antennas from the multiple signal transmissions can contain sufficient information to find the locations of the antennas in antenna centric coordinates. The antenna locations can then be used to find a location of a pill transmitter swallowed by the patient.Type: ApplicationFiled: August 16, 2013Publication date: February 20, 2014Applicant: Rock West Solutions, Inc.Inventors: Thomas Eugene Old, John Christopher Baker, Neal J. Carron, Donald Gordon Pritchett
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Patent number: 8640712Abstract: A bolus for monitoring the parameters of an animal. The bolus will sense selective parameters and will send signals representative of those parameters to a receiver. The bolus includes sensors for sensing a number of parameters such as temperature, pH and movement. The power of the signal inside the animal is greater than that outside the animal since the signal is attenuated by the structure of the animal.Type: GrantFiled: May 26, 2010Date of Patent: February 4, 2014Inventor: William E. Ardrey, Jr.
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Publication number: 20140031642Abstract: A system for detecting clinically-relevant features of a gastrointestinal (GI) tract of a subject. The system comprises an external magnetic field generator adapted to be affixed to a patient for generating at predetermined time intervals a magnetic field with respect to the subject. The magnetic field has a predetermined polarity and flux density, thereby establishing a patient coordinate system based upon the magnetic field. The system includes a capsule adapted to be swallowed by a subject. The system further includes at least one radiation source emitting X-ray or gamma radiation and at least one radiation detector. The radiation detector is configured to detect in a first energy window collimated X-ray fluorescence radiation from the X-ray contrast agent composition excited by the emitted radiation, and to detect a second energy window Compton-backscattered radiation from the X-ray contrast agent and the wall of the GI tract produced in response to the emitted radiation.Type: ApplicationFiled: October 31, 2011Publication date: January 30, 2014Applicant: CHECK-CAP LTD.Inventors: Yoav Kimchy, Anton Plotkin, Ronen Lifshitz, Oleg Obodovsky
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Patent number: 8636648Abstract: An improved endoscopic device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to obtain and store or transmit one or more types of data such as visual image data, laser autofluorescensce data, or ultrasonic waveform data. In another aspect of the disclosure, a probe for autonomously operating within an intestinal tract of a living human is disclosed. In one embodiment, the probe includes: a data processor; an antigen detector; and a communications device. In one variant, the processor comprises at least one sleep mode configured to place at least portions of the probe in a reduced state of power consumption based at least one of (i) a detection of a prescribed antigen; and/or (ii) an absence of a detection of a prescribed antigen.Type: GrantFiled: March 26, 2001Date of Patent: January 28, 2014Assignee: West View Research, LLCInventor: Robert F. Gazdzinski
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Publication number: 20140018643Abstract: The invention relates to a system (1) suitable for being inserted into an anatomical cavity (30), including: a support structure (10), an antenna (10), an assembly (22) of measuring devices, an assembly (26) for transmitting the data of the measurements carried out by the measuring devices (22), which is suitable for communicating with an external entity (E) by means of the antenna (10), and a device (24) for monitoring the assembly of measuring elements and the transmission assembly (26), said antenna consisting of the support structure (10), and the self-contained system being characterized in that the support structure (10) includes a non-conductive junction (20) supporting the assembly (22) of measuring devices, the transmission assembly (26), and/or the monitoring device (24), wherein the junction is suitable for producing an electrical discontinuity within the support structure (10) forming the antenna while mechanically supporting said support structure (10).Type: ApplicationFiled: January 20, 2012Publication date: January 16, 2014Inventors: Charbel Achkar, Julien Molina, Yan Haentjens, Gerard Sou, Alain Le Borgne, Fabien Koskas, Georges Alquie, Michel Schaller
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Patent number: 8626268Abstract: A system and method for detection of colorimetric abnormalities within a body lumen includes an image receiver for receiving images from within the body lumen. Also included are a transmitter for transmitting the images to a receiver, and a processor for generating a probability indication of presence of colorimetric abnormalities on comparison of color content of the images and at least one reference value.Type: GrantFiled: July 3, 2012Date of Patent: January 7, 2014Assignee: Given Imaging Ltd.Inventors: Doron Adler, Ofra Zinaty, Daphna Levy, Arkady Glukhovsky
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Publication number: 20140005504Abstract: A glucose monitoring system, includes a glucose sensor strip or package of strips. The strip includes a substrate and a glucose monitoring circuit that has electrodes and a bodily fluid application portion of selected chemical composition. An antenna is integrated with the glucose sensor strip. An RFID sensor chip is coupled with the glucose sensor strip and the antenna. The chip has a memory containing digitally-encoded data representing calibration and/or expiration date information for the strip.Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicant: ABBOTT DIABETES CARE INC.Inventors: Timothy T. Goodnow, Lei He
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Publication number: 20130345525Abstract: A biochip and nanochip device, or a system of biochips, providing diagnostic testing, sensing and therapeutic functionality useful in diagnosis and treatment of a variety of physiological maladies.Type: ApplicationFiled: June 25, 2012Publication date: December 26, 2013Applicant: International Business Machines CorporationInventor: Eric V. Kline
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Publication number: 20130338452Abstract: Low profile antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include low profile signal transmission antennas configured such that they are flexible or degrade after use, allowing the antenna and attached components to pass easily through the body. Embodiments of the low profile antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.Type: ApplicationFiled: May 6, 2013Publication date: December 19, 2013Applicant: Proteus Digital Health, Inc.Inventor: Proteus Digital Health, Inc.
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Patent number: 8602989Abstract: A capsule medical apparatus system includes: a table for placing a subject thereon along a longitudinal direction; an antenna, which is arranged on a body surface of the subject, for receiving in-vivo information transmitted from a capsule medical apparatus inserted in the subject; a cable for transmitting the in-vivo information received by the antenna; a processing device, which is fixed to a longitudinal end portion of the table, for processing the in-vivo information transmitted via the cable; a rotation mechanism for rotating a connecting portion, at which the cable is connected to the processing device, about a rotation axis lying in the longitudinal direction of the table depending on posture change of the subject.Type: GrantFiled: March 24, 2011Date of Patent: December 10, 2013Assignee: Olympus Medical Systems Corp.Inventor: Atsushi Chiba
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Patent number: 8597186Abstract: Pharmaceutical delivery systems for delivering dosages according to the present invention include a carrier component and a cap configured to seal an internal volume of the carrier component, wherein the cap includes a device that produces a unique current signature. Dosages prepared to be delivered according to embodiments of the invention find use in a variety of different applications, including clinical trials.Type: GrantFiled: January 5, 2010Date of Patent: December 3, 2013Assignee: Proteus Digital Health, Inc.Inventors: Hooman Hafezi, Gregory Moon, Kityee Au-Yeung, Robert Duck, Maria Casillas Holen
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Publication number: 20130310664Abstract: A mechanism is provided. The mechanism includes a user device and a smart pill within a host. The smart pill is communicatively connected to the user device for transmitting and receiving secure communications. Settings of the smart pill while in the host are configured to be changed based on patient category data of the host.Type: ApplicationFiled: June 5, 2012Publication date: November 21, 2013Applicant: International Business Machines CorporationInventors: James R. Kozloski, Clifford A. Pickover
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Publication number: 20130310663Abstract: A mechanism is provided. The mechanism includes a user device and a smart pill within a host. The smart pill is communicatively connected to the user device for transmitting and receiving secure communications. Settings of the smart pill while in the host are configured to be changed based on patient category data of the host.Type: ApplicationFiled: May 21, 2012Publication date: November 21, 2013Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: James R. Kozloski, Clifford A. Pickover
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Publication number: 20130289368Abstract: The invention relates to diagnostic devices, which are capable of characterising gases and other volatile organic compounds (VOCs) present in the gastrointestinal tract, for diagnosing diseases. The invention extends to apparatuses for use in the in vivo detection and characterisation of gases and VOCs, and to methods for diagnosing diseases.Type: ApplicationFiled: October 24, 2011Publication date: October 31, 2013Applicant: The University of WarwickInventors: James Covington, Ramesh Arasaradnam, Chuka Nwokolo
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Publication number: 20130289367Abstract: Technologies are generally described for a system for detecting the presence of gas in the intraperitoneal space of the abdominal cavity and indicating anastomotic leakage. A sensing device may be implanted inside the abdominal cavity of a body near the location of an anastomosis. The sensing device may utilize a sensor configured to detect gas presence and measure the concentrations of gases, including hydrogen sulfide and/or methane, within the intraperitoneal space. The sensing device may be configured to transmit gas detection information to an external wireless communication device, and the wireless communication device may be configured to generate an alert if a gas concentration level rises above a predetermined acceptable level.Type: ApplicationFiled: April 27, 2012Publication date: October 31, 2013Applicant: Empire Technology Development, LLCInventors: Lewis Kruglick, Ezekiel Kruglick
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Patent number: 8570187Abstract: A telemetric system includes a telemetric implant, a reader unit adapted to read signals from the telemetric implant, and an antenna adapted for connection to the reader unit and to receive signals from the telemetric implant. The antenna has a first coil, a second coil, and a connector. The first coil is electrically connected to the second coil, and the connector allows for movement of the first and second coils relative to each other. The antenna may be used to send radio-frequency power to the telemetric implant and receives data from the telemetric implant.Type: GrantFiled: September 5, 2008Date of Patent: October 29, 2013Assignee: Smith & Nephew, Inc.Inventors: Sied W. Janna, Darren James Wilson, Martin S. Goodchild, Peter A. Brady
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Publication number: 20130274567Abstract: The invention relates to a sensor system for implantation into a body of a living being, comprising a measuring unit for measuring parameters of the body and generating corresponding measurement signals, a transmitting unit for transmitting signals using the measurement signals, a control and analysis unit which is connected to the measuring unit and the transmitting unit in order to process and prepare the measurement signals and control the transmitting unit for transmitting the transmitting signals, an energy storing unit for supplying energy to the units, and an outer casing that at least partly surrounds the measuring unit, the transmitting unit, the analysis unit, and the energy storing unit.Type: ApplicationFiled: October 14, 2011Publication date: October 17, 2013Applicant: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V.Inventors: Volker Grosser, Stephan Guttowski, Michael Niedermayer
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Publication number: 20130261410Abstract: A measurement and analysis system for characterizing body core motional acceleration and orientation with respect to gravity, and characterizing the motional acceleration and orientation of an ingestible device relative to the body core with associated activity level, and under some conditions, characterizing the motional acceleration of digestive track lumens relative to the body core with associated activity level. The system comprises an in-vivo ingestible sensing device that travels through the digestive track and an external sensing device attached externally to the body core and each device measures orthogonal acceleration vectors data that are transmitted to a computation device that executes algorithms to determine all characterizations. The benefits of the measurement and analysis system are: 1.) increased understanding of digestive track behaviors, 2.) when combined with ingestible diagnostic systems provides increased accuracy through real time environmental knowledge.Type: ApplicationFiled: March 28, 2012Publication date: October 3, 2013Applicant: Larger Reality Technologies LLCInventor: Roger Davenport
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Patent number: 8547248Abstract: The present invention provides implantable systems that communicate wirelessly with each other using a unique format that enables devices configurations and applications heretofore not possible. Embodiments of the present invention provide communication apparatuses and methods for exchanging information with implantable medical devices. In some embodiments, two implantable devices communicate with each other using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium.Type: GrantFiled: September 1, 2006Date of Patent: October 1, 2013Assignee: Proteus Digital Health, Inc.Inventors: Mark J. Zdeblick, Timothy Robertson
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Patent number: 8540633Abstract: The present invention provides for safe and reliable electronic circuitry that can be employed in ingestible compositions. The ingestible circuitry of the invention includes a solid support; a conductive element; and an electronic component. Each of the support, conductive element and electronic component are fabricated from an ingestible material. The ingestible circuitry finds use in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.Type: GrantFiled: August 13, 2009Date of Patent: September 24, 2013Assignee: Proteus Digital Health, Inc.Inventors: Hooman Hafezi, Eric Snyder, Benedict Costello
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Patent number: 8540631Abstract: Systems and methods provide intrabody communication using acoustic telemetry. The system includes a first or control implant including a first acoustic transducer, and a second implant including a switch and a second acoustic transducer coupled to the switch. The second acoustic transducer receives acoustic signals from the first acoustic transducer for closing the switch to activate the second implant. The second implant may include a sensor for measuring a physiological parameter that is transmitted using acoustic signals including the physiological data to the first implant. For example, the second implant may measure pressure in the patient's heart that may be used by the first implant to control a pacemaker. Alternatively, the second implant may blood sugar concentration that may be used by the first implant to control an insulin pump. Alternatively, the first implant may store and transfer the data to an external device for monitoring the patient.Type: GrantFiled: February 28, 2007Date of Patent: September 24, 2013Assignee: Remon Medical Technologies, Ltd.Inventors: Avi Penner, Eyal Doron
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Patent number: 8540664Abstract: The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.Type: GrantFiled: March 24, 2010Date of Patent: September 24, 2013Assignee: Proteus Digital Health, Inc.Inventors: Timothy Robertson, Yashar Behzadi
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Patent number: 8540632Abstract: Low profile antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include low profile signal transmission antennas configured such that they are flexible or degrade after use, allowing the antenna and attached components to pass easily through the body. Embodiments of the low profile antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.Type: GrantFiled: May 23, 2008Date of Patent: September 24, 2013Assignee: Proteus Digital Health, Inc.Inventors: Timothy L. Robertson, Olivier Colliou, Eric Snyder, Mark J. Zdeblick
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Publication number: 20130245398Abstract: A capsule-type medical device comprises a capsule main unit having functions for being inserted into the body cavity and performing medical acts such as taking images or the like. The capsule main unit comprises therein a magnet which is acted upon by external magnetism, and a spiral portion on the outer perimeter, so that rotating force acting upon the magnet is readily converted into a propelling force for propelling the capsule-type medical device. A flexible insertion portion which is long and small in diameter is provided to the capsule main unit to allow smooth progression through the body cavity, and the center of gravity of the device is placed upon the longitudinal center axis of the capsule main unit, thus facilitating smooth progression through the body cavity.Type: ApplicationFiled: May 3, 2013Publication date: September 19, 2013Applicant: OLYMPUS CORPORATION,Inventors: Takeshi YOKOI, Hironobu TAKIZAWA, Akio UCHIYAMA, Hitoshi MIZUNO
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Publication number: 20130237774Abstract: The present invention may be embodied as an ingestible device capable of sensing one or more chemical parameters. In use, the device can continuously determine the chemical concentrations within an alimentary canal tract. An embodiment of the device comprises a housing resistant to degradation by alimentary canal fluid, a light source, and image capture device. An analyte sensor is configured to obtain at least one measurement of a concentration of analyte in the fluid. The analyte sensor comprises a sensor substance in a sol-gel material so the sensor substance reversibly interacts with an analyte of interest. In addition, the analyte sensor is configured to generate a trigger signal for controlling the operation of subsystems in the device.Type: ApplicationFiled: July 7, 2011Publication date: September 12, 2013Applicant: THERASYN SENSORS, INC.Inventors: Jerome J. Schentag, Frank V. Bright, David T. D'Andrea
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Publication number: 20130225948Abstract: A surgical targeting system of an intramedullary nail, which includes an extracorporeally arranged external transmitting unit. Further included is a plurality of first transponder units coupled with and arrayed along the length of the intramedullary nail, each adapted to be actuated by the external transmitting unit. Additionally, a plurality of holes are disposed within and arrayed along the length of the intramedullary nail. Each of the plurality of holes are situated between each of the plurality of first transponder units. Further, a first transmission section is between the external transmitting unit and each of the plurality of first transponder units via which the plurality of first transponder units are actuated. Additionally included is a second transmission section through the intramedullary nail between the plurality of first transponder units and a second transponder unit.Type: ApplicationFiled: April 8, 2013Publication date: August 29, 2013Applicant: STRYKER TRAUMA GMBHInventor: Stryker Trauma GmbH
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Publication number: 20130217982Abstract: The ingestible event marker data framework provides a uniform, comprehensive framework to enable various functions and utilities related to ingestible event marker data (IEM data). Included are a receiver adapted to be associated with a body of an individual, the receiver configured to receive IEM data; a hub to receive the IEM data; and at least one IEM data system to receive the data from the hub. Among other information, behavioral data and predictive inferences may be provided.Type: ApplicationFiled: March 15, 2013Publication date: August 22, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventor: Proteus Digital Health, Inc.
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Patent number: 8512241Abstract: A method of communicating with an ingestible capsule includes detecting the location of the ingestible capsule, focusing a multi-sensor acoustic array on the ingestible capsule, and communicating an acoustic information exchange with the ingestible capsule via the multi-sensor acoustic array. The ingestible capsule includes a sensor that receives a stimulus inside the gastrointestinal tract of an animal, a bidirectional acoustic information communications module that transmits an acoustic information signal containing information from the sensor, and an acoustically transmissive encapsulation that substantially encloses the sensor and communications module, wherein the acoustically transmissive encapsulation is of ingestible size. The multi-sensor array includes a plurality of acoustic transducers that receive an acoustic signal from a movable device, and a plurality of delays, wherein each delay is coupled to a corresponding acoustic transducer.Type: GrantFiled: September 6, 2007Date of Patent: August 20, 2013Assignee: Innurvation, Inc.Inventors: William Robert Bandy, Roger Allen Davenport, Yuri Okunev
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Publication number: 20130197323Abstract: An animal monitoring device configured as a bolus for oral administration to reside in an animal's stomach. The bolus has a substantially inert solid body with a hollow inside space to receive the animal monitoring device. The animal monitoring device includes a radio frequency generator, an animal identification information encoder for outputting the animal identification information of the particular animal. The animal monitoring device can further include sensors to detect physiological and non-physiological animal characteristics such as temperature and a sensed animal characteristic encoder for outputting sensed animal characteristic information.Type: ApplicationFiled: October 19, 2011Publication date: August 1, 2013Applicant: Bella Technologies, LLCInventors: Nicholas P. Rettedal, Stephen M. Weilnau, Scott R. Cockroft, Billy J. Yeager, Jerry A. Hornick, John B. Lienau
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Publication number: 20130178721Abstract: A bolus for use in a ruminant animal's reticulum includes a cavity (100) configured to receive ruminal fluids present in the stomach. The cavity has walls (110) of a dielectric material and is encircled by a coil member (120), which is configured to subject the ruminal fluids to an electro-magnetic field. A Sensor element (310) measures the electromag-netic field's influence on the ruminal fluids and thus register an electromagnetic property representative of an acidity level of said fluids. A transmitter (410) transmits a wireless output signal (SD) reflecting the acidity measure.Type: ApplicationFiled: September 28, 2011Publication date: July 11, 2013Applicant: DELAVAL HOLDING ABInventors: Uzi Bird, David Livshits
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Patent number: 8480616Abstract: The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.Type: GrantFiled: March 24, 2010Date of Patent: July 9, 2013Assignee: Proteus Digital Health, Inc.Inventors: Timothy Robertson, Yashar Behzadi
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Patent number: 8483792Abstract: Embodiments herein provide an analyte sensor subassembly that provides an integrated structure enabling suitably secure electrical contact between an analyte sensor and the electronic components of an analyte sensor assembly. An analyte sensor subassembly assists the process of inserting the sensor into skin. An analyte sensor subassembly may operate in concert with one or more sensor insertion tools to provide insertion of an analyte sensor into the skin of a subject/patient. Associated devices, such as channel guides and sensor insertion tools, are also provided, as are methods of operation and sensor insertion.Type: GrantFiled: March 17, 2009Date of Patent: July 9, 2013Assignee: iSense CorporationInventors: Dennis Slomski, Robert Bruce, Jon Fortuna, David B. Kreitlow
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Publication number: 20130172694Abstract: A swallowable capsule (10) is provided with a drug reservoir (18) and at least one sensor (13). The drug reservoir (18) is arranged to hold a pharmaceutical composite. A wall (12) of the drug reservoir (18) comprises at least one opening for allowing fluid from the surroundings of the capsule (10) to enter the drug reservoir (18) and for allowing dissolved drug or liberated particles of the pharmaceutical composite to enter the surroundings of the capsule (10). The at least one sensor (13) is provided for monitoring a condition of the surroundings of the capsule (10).Type: ApplicationFiled: December 14, 2010Publication date: July 4, 2013Inventors: Hans Zou, Jeff Shimizu
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Patent number: 8469885Abstract: The present invention provides for safe and reliable electronic circuitry that can be employed in ingestible compositions. The ingestible circuitry of the invention includes a solid support; a conductive element; and an electronic component. Each of the support, conductive element and electronic component are fabricated from an ingestible material. The ingestible circuitry finds use in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.Type: GrantFiled: August 13, 2009Date of Patent: June 25, 2013Assignee: Proteus Digital Health, Inc.Inventors: Hooman Hafezi, Eric Snyder, Benedict Costello
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Publication number: 20130150685Abstract: A system and method for monitoring a surgical site within a body, including an elongate sensory subsystem adapted to be placed or implanted near to the surgical site including a sensor for collecting physiological data from the surgical site and a communication subsystem in communication with the elongate sensory subsystem. An elongate probe extending from the communication subsystem to the vicinity of the surgical site adapted to collect physiological data pertaining to the surgical site. A method for monitoring the surgical site to determine the early onset of complications is disclosed. A method for monitoring the integrity of an organ and in particular monitoring the integrity of an anastomosis is also disclosed.Type: ApplicationFiled: August 23, 2011Publication date: June 13, 2013Inventor: Landy Aaron Toth
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Publication number: 20130144132Abstract: Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.Type: ApplicationFiled: January 31, 2013Publication date: June 6, 2013Applicant: PROTEUS DIGITAL HEALTH, INC.Inventor: PROTEUS DIGITAL HEALTH, INC.
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Publication number: 20130123586Abstract: A method and system for determining intestinal dysfunction condition are provided by classifying and analyzing image frames captured in-vivo. The method and system also relate to the detection of contractile activity in intestinal tracts, to automatic detection of video image frames taken in the gastrointestinal tract including contractile activity, and more particularly to measurement and analysis of contractile activity of the GI tract based on image intensity of in vivo image data.Type: ApplicationFiled: December 17, 2012Publication date: May 16, 2013Applicant: GIVEN IMAGING LTD.Inventor: GIVEN IMAGING LTD.
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Publication number: 20130109933Abstract: An implant, having a preferably hollow-cylindrical base body and comprising a device that is used to measure the degree of endothelialization and disposed on and/or in the base body, wherein the device comprises an acoustic resonator and/or an electric resonator. The invention further relates to a system, comprising a catheter and such an implant.Type: ApplicationFiled: October 25, 2012Publication date: May 2, 2013Applicant: BIOTRONIK AGInventor: BIOTRONIK AG