Abstract: An endotracheal tube positioning device includes a first Hall sensor, a second Hall sensor spaced a predetermined distance from the first Hall sensor, a converter, and an integrated circuit board electrically connecting the first Hall sensor and the second Hall sensor to the converter, wherein a position range is established for the device based on a symmetry of voltage readings provided from the first and second Hall sensors to the converter. An endotracheal tube positioning system includes an endotracheal tube having a magnet provided toward a distal tip end, an endotracheal tube positioning device having a first Hall sensor and a second Hall sensor, the positioning device configured to adhere to a skin surface, and a monitor for receiving data based on voltage values provided by the first and second Hall sensors, the data indicating a position of the magnet relative to the adhered position of the positioning device.

Abstract: Among other things, a gastrostomy tube including a feeding tube that spans between an outer retention device and an inner retention device is disclosed. Embodiments of the inner retention device include an ultrasonic marker positioned within the inner retention device. The inner retention device and the ultrasonic marker have a variety of shapes or embodiments. The ultrasonic marker positioned in the inner retention device eliminates or reduces the use of fluoroscopy or endoscopy to position and later verify the location of the gastrostomy tube in a patient. Beneficially, the health risks associated with fluoroscopy and endoscopy are thereby eliminated or reduced with their associated disuse thereof. Moreover, the use of expensive hospital suites or operating rooms is eliminated or reduced with the use of portable ultrasound equipment that can be transported to a patient's bedside for verification of the location of the ultrasonic marker.

Abstract: There is described an MRI system in which the detection of the NMR signal is performed by a resonant input at a median field range above 100 gauss and where the main field is cycled to a low field of below 50% of the resonant frequency after the excitation of the NMR signal for a period sufficient to develop differences in magnetisation (T1). The advantage of this system is that images can be generated at much lower field intensities than prior art systems and is able to detect abnormalities in tissue such as cancerous tissues in a patient.

Abstract: An integrated metal detector-portable medical device adapted to identify metals in a human body, where the metal detector is in connection with the portable medical device. The metal detector includes: at least one transmitting means adapted to generate a second magnetic field so as to induce a magnetic field generated by a metal; at least one sensor adapted to detect a magnetic field generated by the metals to be detected; and at least one signaling means adapted, upon detection of a magnetic field, to alert the identification of metals, if the intensity of a magnetic field is above a predetermined value.

Abstract: A system and method for ultrasound image guided surgical procedures such as needling or catheterisation, in which an ultrasound transducer is provided with a magnetometric detector for detecting the magnetic field emanating from a magnetised tissue-penetrating medical tool such as a needle or catheter. The detection of the magnetic field allows the position of the tool to be tracked magnetically and the position can be displayed on the ultrasound image. The position of the tool is determined from the magnetic field measurements by use of a look-up table of magnetic field values for the field emanating from the tissue-penetrating medical tool.

Abstract: The disclosures is directed to cough detectors, methods and kits. Cough detectors can include, for example, a housing adaptable to engage an abdomen or thorax of a mammal; a first sensor comprising an AGM sensor positioned within the housing; a processor in communication with the AGM sensor wherein the processor is capable of receiving a signal from the AGM sensor and analyzing the signal to determine whether the signal is characterizable as a cough; and a power source.

Abstract: A diagnostic system for monitoring changes in a medium is disclosed. The system includes a transmitter configured to generate and transmit a time-varying magnetic field into a medium responsive to a first signal. The system also includes a receiver positioned on an opposite side of the medium from the transmitter and configured to generate a second signal responsive to a received magnetic field at the receiver. The system also includes a processing unit configured to determine a phase shift between the transmitted magnetic field and the received magnetic field for a plurality of frequencies of the transmitted time-varying magnetic field.

Abstract: Methods for determining the likelihood that a subject will be a placebo responder in a clinical study are provided. Also provided are methods for eliminating likely placebo responders from a clinical study a priori, thereby simplifying data analysis and minimizing or eliminating any confound that arises in the analysis as a result of placebo response. Databases and computer systems using the methods are also disclosed herein. Methods for assessing likelihood of a subject experiencing a response shift are also provided.

Abstract: A method includes generating a magnetic field in a predefined volume. A reference model is defined, which models the magnetic field at multiple points in the volume using spherical harmonics. The magnetic field is measured by a field detector, which is coupled to an intra-body probe inserted into an organ of a living body located in the volume. A cost function is defined by comparing the measured magnetic field with the reference magnetic field model within the volume. The cost function is minimized by a computation over dipole terms in a derivative over the cost function so as to find a position and orientation that matches the measured magnetic field. The found position and orientation is outputted as the position and orientation of the probe in the organ.

Abstract: A medical probe includes a flexible insertion tube, having a distal end for insertion into a body cavity of a patient, and a distal tip, which is disposed at the distal end of the insertion tube and is configured to be brought into contact with tissue in the body cavity. A coupling member couples the distal tip to the distal end of the insertion tube and includes a tubular piece of an elastic material having a helical cut therethrough along a portion of a length of the piece.

Abstract: A monitoring system includes a Doppler radar formed with an IEEE 802 protocol transmitter and an IEEE 802 protocol receiver to detect motion, wherein frequency waves are transmitted by the IEEE 802 protocol transmitter and reflected waves are received by the IEEE protocol 802 receiver; and an analyzer to perform Doppler operations using the IEEE 802 protocol transmitter and receiver, wherein the analyzer calibrates a training Doppler radar signal during a training phase to develop a model and wherein the analyzer applies the model with the Doppler radar signal during an operational phase to determine position.

Abstract: The purpose of this invention is a device and a method which will permit the acquisition and subsequent reconstruction of objects with volume throughout the total external surface. This invention is characterised in that it has a particular mode of acquisition on the free fall object in such a way that there is no support surface which prevents acquisition of the surface which would be hidden by said support. The invention is also characterised by special modes of distribution of the cameras which optimise image capturing and provide useful information in the subsequent reconstruction of the volume through computer means.

Abstract: Implantation imaging techniques are presented herein to provide a surgeon with visual feedback during implantation of an implantable medical device in a recipient. The implantation imaging techniques may include the generation of a magnetic field that induces a voltage at a coil positioned in the recipient. The induced voltage is used to determine the orientation of the coil positioned in the recipient relative to direction of the magnetic field.

Abstract: A surgical system comprises a magnet having a magnetic field. The magnet is disposed with a first spinal implant. A sensor is disposed with a first end of a second spinal implant. The sensor is configured to measure the magnetic field relative to the second spinal implant. Indicia represents position and orientation of the first spinal implant relative to the second spinal implant based on the measured magnetic field. Systems and methods are disclosed.

Abstract: Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.

Abstract: The present invention relates to the diagnosis and treatment of stress urinary incontinence. In one embodiment, the diagnosis and treatment involves the use of a positional feedback catheter. Positional sensors may be embedded in the catheter to provide real-time tracking of the position and movement of the catheter.

Abstract: Systems and method utilizing microelectronic devices for determining relative positions such as distances and/or angles between at least two points is described. The points may be locations of parts of the body such as the fingers on a person's hand. A first microelectronic device is adapted to emit magnetic signals and at least one second microelectronic device is adapted to receive the magnetic signals, wherein a controller is adapted to communicate with the first and second microelectronic devices. The second microelectronic device and/or the controller are adapted to determine a distance and angle between the first and the second microelectronic devices based on the strength of the magnetic signals received by the second microelectronic device.

Abstract: A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and a sensor disposed within the insertable portion at a distal end of the senior wire. The sensor is configured to measure a parameter when inserted inside the patient. The transceiver unit may comprise: a housing adapted to be connected to a proximal end of the sensor wire; and a first communication module within the housing adapted to wirelessly communicate by a communication signal with an external second communication module in order to transfer information to the external second communication module.

Abstract: A magnetic field measurement apparatus includes a probe beam irradiating unit that radiates a probe beam. A gas cell is arranged on an optical axis of the probe beam and shows a linear dichroism with respect to the probe beam between a first axis and a second axis. Another gas cell is arranged on the optical axis of the probe beam on the opposite side of the probe beam irradiating unit with respect to the gas cell, and shows a linear dichroism with respect to the probe beam between a third axis and a fourth axis, which are different from the first and the second axes. A measuring unit measures a difference between magnetic fields in the gas cells and on the basis of amounts of change of a plane of polarization of the probe beam that has passed through the gas cell and the gas cell.

Abstract: Provided herein, inter alia, is a system for indicating the location of a dental drill includes a dental handpiece, which further includes the dental drill. A plurality of sensors detect a magnetic field and produce a set of outputs, which are usable at least in part to indicate the location of the dental drill. The sensor outputs may be processed to produce an indication of the spatial relationship of the drill to a patient's dentition. The indication is preferably graphical, and may be presented to a dental professional using the system during an implant procedure to provide visual feedback about the procedure. The indication may be repeatedly updated, substantially in real time.

Abstract: A system and method for measuring volumes and areas using electromagnetic induction techniques. A current is generated and fed into one of two coil assemblies to induce voltage into another coil assembly to provide accurate values for volume or area.

Abstract: The invention provides methods and systems for determining the position of a remote object such as an in vivo medical device such as capsule or probe within a medical patient. Integrated computer and computer executable remote permanent magnetic dipole position and orientation detection system monitors remote object movement. User interface displays remote permanent magnetic dipole location and orientation in a 3-dimensional view. Database stores object position movement in association with time. Magnetic sensor planes detect remote objects with permanent magnetic dipole and generate magnetic field information signal. Computer stores and searches location and posture information use a file.

Abstract: A system and method for determining a position of a medical device within a body are provided. The system includes an electronic control unit that receives position signals from position sensors of a first type and a second type disposed on the device and applies a filter to each of the position signals to obtain filtered estimated positions for each sensor. The unit computes a spline connecting the position sensors of the first type responsive to the filtered estimated positions for the sensors and estimates a spline position for the sensor of the second type along the spline. The unit generates maps between the spline position and filtered and unfiltered estimated positions for the sensor of the second type and determines actual positions for the sensors of the first type responsive to the filtered estimated position for the sensors and a composite map of the two maps.

Abstract: Devices having the capability to both locate and retrieve objects are disclosed. More particularly, the present disclosure relates to devices having a probe comprising an ultrasound detector for locating and a grasper for retrieving objects from a medium. The present disclosure further relates to devices having a probe comprising an electromagnetic detector for locating and a grasper for retrieving metallic objects from a medium. Devices of the present disclosure are specifically adapted for use as medical devices for locating and retrieving a foreign body in a subject in need.

Abstract: Allows the specificity of an automatic MRT detection to be increased in a simple manner. This is achieved using an automatically calibrating position sensor, so that the user does not have to perform additional calibration of this sensor. Incorrect sensor calibrations are thus eliminated as well.

Abstract: The present invention provides a packaging technique and apparatus that incorporates a flexible substrate package with a three-axis magnetic sensor for three-axis sensing in an implantable medical device. The apparatus includes three single-axis magnetic sensor integrated circuits (ICs) that are mounted to a substrate and encapsulated with a polymer mold compound. The substrate is excised around each of the sensor ICs to form panels that are folded to align the three single-axis sensors in the x, y and z axis.

Abstract: Exemplary method, system and computer-accessible medium can be provided for diagnosing at least one disease and/or a subtype within a disease. For example, it is possible to determine at least one region of interest, and obtain a plurality of data points associated with each of such region(s) of interest. It is also possible to identify a particular pattern of the data points across each of such region(s) of interest. Further, it is possible, e.g., using a computer arrangement, to determine a likelihood of the disease(s) and/or the subtype by comparing the particular pattern to at least one known pattern.

Abstract: An apparatus and method for quantifying myocardial kinetics by positioning two sensors on a myocardial substrate site so that one sensor is directly opposing the other along a ventricular wall; tracking a relative displacement between the two sensors; and determining whether there is an infarct based on the tracked relative displacement.

Abstract: Certain embodiments provide an automatic diagnosis support apparatus includes extracting a plurality of parameters associated with a predetermined object by using medical information acquired by a medical image diagnosis apparatus and extracting the plurality of parameters for each disease associated with a disable-bodied person by using medical information associated with the disable-bodied person, calculating a ruler associated with each disease case by executing an MT system using the plurality of parameters for each disease associated with the disable-bodied person, calculating a distance between the object and a state space of the disable-bodied person associated with the each disease by executing the MT system using a plurality of parameters associated with the object, determining a disease type of the object by using the ruler and a distance between the object and a state space of a disable-bodied person, and generating diagnosis support information based on the determination result.

Abstract: Disclosed is a magnetoencephalography meter which includes a plurality of optical pumping magnetometers which are arranged in a helmet shape to cover the head of the subject. Each optical pumping magnetometer has a vapor cell which is filled with alkali metal atoms and is arranged substantially in parallel to the surface of the head of the subject, a laser light emission unit that emits laser light in a direction toward the head of the subject and causes laser light to enter the vapor cell, a reflection unit that reflects laser light passed through the vapor cell in a direction away from the head of the subject which is a direction substantially perpendicular to the surface of the head of the subject, and a polarization change detection unit that receives laser light reflected by the reflection unit and detects change in polarization of laser light.

Abstract: A coordinate system registration module, including radiopaque elements arranged in a fixed predetermined pattern and configured, in response to the radiopaque elements generating a fluoroscopic image, to define a position of the module in a fluoroscopic coordinate system of reference. The module further includes one or more connections configured to fixedly connect the module to a magnetic field transmission pad at a predetermined location and orientation with respect to the pad, so as to characterize the position of the registration module in a magnetic coordinate system of reference defined by the magnetic field transmission pad.

Abstract: A catheter having a sensor at a distal end thereof, useable to detect and create signals from an electromagnetic field. The sensor is constructed and arranged to leave a lumen of the catheter open such that it may be used to pass instruments therethrough once a target location has been reached.

Abstract: Method for locating a brain activity, comprising the steps consisting in: a) acquiring data indicative of sensory stimuli addressed to, or deliberate actions performed or imagined by, a subject; b) by means of a plurality of sensors, acquiring signals representative of an activity, associated with said stimuli or deliberate actions, of respective regions of the brain of said subject; and c) for each said sensor, quantifying a correlation that exists between said data indicative of sensory stimuli or of deliberate actions and the signals acquired; characterized in that, for each said sensor, said correlation is established between a scalar variable indicative of a said sensory stimulus or of a said deliberate action and a multidimensional variable representative of signals that are associated therewith. Application of this method to the determination of optimum locations for brain activity sensors for direct neural control.

Abstract: An optical pumping magnetometer measures a magnetic field of a measurement object using optical pumping. The optical pumping magnetometer includes a nonmagnetic cell in which at least an alkali metal is enclosed and which has optical transparency and heat resistance, a laser beam irradiation unit which radiates a laser beam to the cell and optically pumps at least the alkali metal, a detecting unit which receives a transmission laser beam transmitted through the cell and detects a detection signal related to the magnetic field, and a high frequency voltage applying unit which applies a high frequency voltage to a pair of application units provided on the cell and heats the cell by dielectric heating.

Abstract: It is intended to provide a drug delivery system which makes it possible to solve the existing technical problems and is easily usable in practice. A drug, which comprises an organic compound or an inorganic compound and has been magnetized by modifying a side chain and/or crosslinking side chains, is induced by a magnetic force into target tissues or an affected part.

Abstract: A system for navigating a surgical instrument adjacent tissue of interest is provided and includes a magnetic device and a surgical instrument. The magnetic device is positionable within a body of a patient. The surgical instrument includes a magnetic detection device that is operably disposed thereon to detect the magnetic device. The surgical instrument is configured to remove tissue of interest within the patient.

Abstract: The invention comprises a patient positioning and/or repositioning system, such as a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle radiation therapy. Patient positioning constraints optionally include one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are preferably movable and/or under computer control for rapid positioning, repositioning, and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the charged particle beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract: Magnetocardiogram (MCG) provides temporal and spatial measurements of cardiac electric activities, which permits current localization. An MCG device usually consists of a small number of magnetic sensors in a planar array. Each sensor provides a highly low-resolution 2D MCG map. Such a low-res map is insufficient for cardiac electric current localization. To create a high resolution MCG image from the sparse measurements, an algorithm based on model learning is used. The model is constructed using a large number of randomly generated high resolution MCG images based on the Biot-Savart Law. By fitting the model with the sparse measurements, high resolution MCG image are created. Next, the 2D position of the electric current is localized by finding the peak in the tangential components of the high resolution MCG images.

Abstract: A system and method of detecting and assessing a tissue surface property without a separate access port to internal anatomical structures. The system includes a first unit positioned outside the patient's body and a second unit positioned inside the patient's body. The first unit includes a magnetic field source and a force sensor and is positioned outside the patient's body in a position that enables magnetic coupling with the second unit, which is inside the patient's body. The second unit includes a magnetic field source, a processor, a sensor, a telemetry unit, a power source, and an optional actuator or other components. The resulting attractive force between the internal and external magnetic field sources can be perceived by the force sensor of the first unit. By varying the distance between the two units, the attractive force triggers a variable stress on the tissue surrounding the second unit in the direction of the magnetic field source in the first unit.

Abstract: A method for targeting a landmark of an orthopaedic implant comprises implanting the orthopaedic implant in a body. The orthopaedic implant having at least one landmark defining two or more locations for targeting and a first magnetic sensor located at a known distance from at least one of the two or more locations. The method includes comprises identifying one of the locations using a landmark identifier, the landmark identifier having at least one of a second magnetic sensor and a magnetic field generator, installing a transfixion element in the at least one landmark, and identifying a second location using the landmark identifier.

Abstract: Described herein is an apparatus for locally monitoring nerve activity that may be incorporated into a nerve ablation catheter. Such a catheter is equipped with magnetic sensing for both identifying nerves and assessing the success of the ablation. The catheter is also equipped with an ablation instrument for both stimulating and destroying nerve tissue.

Abstract: A method for computing a quantitative metric indicative of pain experienced by a subject using an electrophysiological signal detection system is provided. Electrophysiological data are acquired from a subject with the electrophysiological signal detection system. Modulations in the acquired electrophysiological data that are associated with pain experienced by the subject during the acquisition of the electrophysiological data are identified. A quantitative metric indicative of the pain experienced by the subject is computed by processing the identified modulations in the acquired electrophysiological data.

Abstract: To provide a highly reliable inspection device that prevents a loss in reliability of inspection that uses information from a position detector as a result of the influence of magnetic bodies or the like that are present in the environment, the inspection device includes biological information measurement units that measure biological information of an inspected target and form an image containing the biological information, a magnetic position detector that detects the position of at least one of the biological information measurement units and the inspection target, and a control unit that controls the biological information measurement units and the magnetic position detector; and further includes the control unit being provided with an environmental magnetic field measurement unit that uses the output of the magnetic position detector to measure distortion of the magnetic field in the measured space in which the biological information measurement units are placed.

Abstract: Magnetic particle imaging allows the imaging of fast tracer dynamics, but there is no native tissue contrast. A combination with MRI solves this issue. However, coil geometries in MPI and MRI differ significantly, making direct use impractical. According to one aspect of the present invention it is proposed to use pre-polarized MRI to overcome these difficulties. Further, methods and arrangements are proposed to achieve MRI imaging with minimal additional hardware.

Abstract: A drug delivery device includes a catheter having first and second ends; a flexible membrane having a rim securely connected to an inner surface of the catheter to define a first volume between the first end and the flexible membrane, and a second volume between the flexible membrane and the second end, such that the second volume is substantially the same as a desired drug volume; and a pressurizable member coupled to the catheter for operably delivering a drug. In use, a desired volume of the drug is preloaded into the second volume of the catheter that in turn is slid into a guidance device, when the guidance device is placed in a target of interest, the pressurizable member applies a pressure into the first volume to exert a force upon the flexible membrane to operably squeeze the second volume, thereby unloading the drug into the target.

Abstract: The human mirror neuron system includes neurons that fire both when an individual performs an action and when the individual observes the action being performed by another. Neuro-response data involving the mirror neuron system is collected as a subject is exposed to stimulus material. The stimulus material may include individuals performing actions such as making a purchase, accepting an offer, participating in an activity, etc. Neuro-response data involving the mirror neuron system of the subject is analyzed to determine the propensity of the subject to act.

Abstract: A method for identifying and activating specific axonal pathways for achieving therapeutic benefits during a neural stimulation, such as deep brain stimulation. Clinical data, diffusion tensor tractography, and computer models of patient-specific neurostimulation may be used to identify particular axonal pathways activated by deep brain stimulation and to determine their correlations with specific clinical outcomes.

Abstract: A method is provided for creating a volume graphic via a catheter for introduction into a vessel which has an ultrasound unit, which is embodied to transmit ultrasound, to measure an echo of the transmitted ultrasound, and to create image data for a two-dimensional cross-section of the vessel on the basis of the measured echo. The method involves creating image data of a cross-section with the ultrasound unit at a plurality of different positions on a movement track of the catheter, and, in addition to the image data, creating position data for the current position of the ultrasound unit with a localization device. The method further involves creating the volume graphic from the image data of all cross-sections in which the cross-sections are arranged relative to one another in accordance with the position data.

Abstract: A method and system for determining the mechanism of cardiac arrhythmia in a patient is disclosed. The method basically entails measuring the impedance of cardiac tissue in a portion of the patient's heart using a catheter during an episode of supraventricular tachycardia to produce an iso-impedance map of that cardiac tissue on a video display and analyzing the pattern of the iso-impedance map to differentiate focal arrhythmia caused by a circumscribed region of focal firing and reentrant arrhythmia caused by a macroreentrant circuit. The method can also be used to identify regions of coherent rapidly conducting tissue e.g., Bachman's bundle or the inferoposterior pathway insertion points, to identify focal “mother rotors” throughout the left atrium that may participate in the generation and maintenance of atrial fibrillation and to identify areas of CAFE (complex atrial/fractionated electrograms) that truly reflect these mother rotors.

Abstract: A system for detecting clinically-relevant features of a gastrointestinal (GI) tract of a subject. The system comprises an external magnetic field generator adapted to be affixed to a patient for generating at predetermined time intervals a magnetic field with respect to the subject. The magnetic field has a predetermined polarity and flux density, thereby establishing a patient coordinate system based upon the magnetic field. The system includes a capsule adapted to be swallowed by a subject. The system further includes at least one radiation source emitting X-ray or gamma radiation and at least one radiation detector. The radiation detector is configured to detect in a first energy window collimated X-ray fluorescence radiation from the X-ray contrast agent composition excited by the emitted radiation, and to detect a second energy window Compton-backscattered radiation from the X-ray contrast agent and the wall of the GI tract produced in response to the emitted radiation.