Abstract: Embodiments of a lumenally-active system and method of use and control thereof are disclosed. According to various embodiments, a lumenally-active device is positioned in a body lumen of an organism, where the device may sense a parameter of a fluid in the body lumen and perform an action on the fluid. Control logic and/or circuitry may be located on the device, or the system may include a separate control module. Liquid or gaseous fluids may be treated by embodiments of the device. Actions may include, for example, modification of a body fluid by addition or removal of a material, or by modification of a property of a body fluid or a component thereof.

Abstract: An air sampling apparatus is disclosed, including a closed loop system for extracting air to be sampled into an analysis device such as a gas chromatograph, which is further coupled to an output. The closed loop sample extraction method reduces contaminants that can otherwise be introduced into air samples.

Abstract: A device combining a fuel-cell-type breathalyzer with an electrochemical saliva drug test. The saliva drug tester comprises a disposable test strip-electrode module assembly and an analyzer module. The saliva is squeezed out of an absorbent swab when the test strip is inserted into the electrode module. The electrode module can also carry information that is read and evaluated by the analyzer, e.g. for verification of the electrode module.

Abstract: Disclosed is a mobile device (15) for analysing breath samples, comprising:—at least one mouthpiece (16) provided with at least one inlet opening (17) and at least one outlet opening (21) for allowing a person to respectively inhale and exhale via the mouthpiece,—at least one air filter (20) connected to the mouthpiece for filtering ambient air to be inhaled by the person,—at least one analysis compartment (19) connecting to the outlet opening of the mouthpiece and provided with at least one chemical trace detector (1), wherein the chemical trace detector comprises: at least one semi-conducting sensor (2); at least one heating element (4) for heating the semi-conducting sensor; at least one processor (6) for controlling the heating element; and a detection circuit (7) for detecting the change in resistance of the semi-conducting sensor which is at least partially determined by the presence of at least one chemical trace which reacts in the presence of the semi-conducting sensor.

Abstract: In a method for determining the ventilation of a lung of an object under examination by magnetic resonance imaging, at least two first lung-representing image data sets are acquired at different intervals of the breathing phase. The density change of the lung tissue is automatically determined from the signal difference between the image signals of the first image data sets in at least one corresponding region of the first lung-representing image data set. The lung or the thorax volume is automatically determined using at least two of the first image data sets, or using at least an additional second lung-representing image data set in a breathing phase that corresponds with the breathing phase of a first image data set. The localized, quantitative ventilation of the lung is automatically calculated depending on the density change of the lung tissue and the change of the lung or thorax volume.

Abstract: Disclosed is a system and method for monitoring the breath chemistry of a patient's breath using a specially designed self-condensing sensor module mounted in a mask, nasal cannula, headband with boom apparatus, or similar device for directing the patients' breath towards the self-condensing sensor. Monitoring of a patient's breath pH provided by the miniaturized self-condensing pH sensor provides for real-time monitoring of patient airway pH values. The specially designed self-condensing sensor module incorporates a data transfer means, e.g. direct wiring or by providing a transmitter with an antenna for wireless transferring of the pH data to a processing receiver. The self-condensing pH sensor comprises a multi-tubular design with the outer tubular member housing a silver chloride reference element, an ion conducting path, and an antimony sensor plug isolated in an inner tubular member that is co-linearly or coaxially configured with the outer tubular member.

Abstract: A mask configured to be attached to the face of a subject includes a wall section that defines an internal space and covers at least a portion of a nose and a mouth of the subject, an expired gas introduction section that is disposed in the internal space and introduce the subject's expired gas, and a communication section defining a communication channel through which the subject's expired gas introduced from the expired gas introduction section is introduced into an expired gas concentration detection sensor. The position of the expired gas introduction section in the internal space is variable.

Abstract: A method, device, and computer program product for improving accuracy of a respiratory gas measurement from a subject ventilated at a predetermined respiration rate through a ventilator. A respiratory gas measurement value is acquired within a first expiration period of the subject, thereby to obtain a first measurement value. The ventilator is paused for a pause period within a second expiration period of the subject and a respiratory gas measurement is performed within the pause period, thereby to obtain a second measurement value. A correction factor is then determined based on the first measurement value and the second measurement value and the correction factor is employed to correct subsequent respiratory gas measurement values obtained from the subject at the predetermined respiration rate, thereby to improve the accuracy of the measurement.

Abstract: A system and method for aiding in the diagnosis of a respiratory dysfunction is described. More particularly, a system and method for aiding in the diagnosis of one or more pulmonary embolisms is described. The system and method described herein include a plurality of sensors, a thermal control system, and a controller coupled to the plurality of sensors and the thermal control system for aiding in the diagnosis of a respiratory dysfunction.

Abstract: A method of detecting at least one of analyte in an environment (such as in breath) includes providing a structure including nanostructures in contact with titanium dioxide, applying electromagnetic radiation to the structure for a period of time, measuring at least one response and using the measured response to determine the presence of the analyte in the environment.

Abstract: A breath parameter measuring device is described which takes into account breathing patterns which historically have been incompatible with accurate measurements. In particular, during fast breathing patterns, the sensor performing the measurement may not be able to respond quickly enough to provide the true reading. The disclosure may be useful for example in the case of neonatal breath carbon dioxide measurements.

Abstract: A breath analysis device is described which minimizes mixing of gases between one section of a breath and another section of breath. In particular for example, when sampling and analyzing the end-tidal section of exhaled gas, the system may avoid mixing that can occur inside the device, between the end-tidal sample and the gases before and after the end-tidal sample. The system accomplishes this with an ultra-low uniform cross section fluid pathway, which includes componentry with ultra-low dead space.

Abstract: Luer connector including a primary Luer male connector having a secondary female section extending from a top distal part of the primary Luer male connector back towards a proximal part thereof, the primary Luer male connector including a first inner fluid flow channel extending from a proximal end thereof to the secondary female section, the primary Luer male connector being configured to mate with a primary Luer female connector having a secondary male section including a second inner fluid flow channel.

Abstract: A breath analysis device is described which obtains a desired segment of one or more breaths, and analyzes that or those samples for compositional analysis. A pneumatic control system may obtain these segments homogeneously, may reduce the amount of gases included from other segments of the breath, and may reduce mixing with other segments once obtained. These pneumatic control systems can be used for on-board compositional analysis, or for modular or off-board compositional analysis.

Abstract: A breath analyzer, a system, and a computer program for administering a breath analysis to a donor and recording a breath analysis result. Embodiments of the invention authenticate that the breath analysis was performed correctly, preserves the breath analysis results by communicating with other devices, and presents the breath analysis results by superimposing them on recorded video data. The breath analyzer includes a breath receptor for receiving a breath sample from the donor, an analyzing element for determining a breath analysis result, a communications element for sending information indicative of the breath analysis result to a recording device manager, and a housing for securing the components in a handheld device. The system comprises the breath analyzer, a recording device manager for synchronizing the recordings, and at least one ancillary camera for recording the breath analysis.

Abstract: Devices and methods for sleep detection involve the use of an adjustable threshold for detecting sleep onset and termination. A method for detecting sleep includes adjusting a sleep threshold associated with a first sleep-related signal using a second sleep-related signal. The first sleep-related signal is compared to the adjusted threshold and sleep is detected based on the comparison. The sleep-related signals may be derived from implantable or external sensors. Additional sleep-related signals may be used to confirm the sleep condition. A sleep detector device implementing a sleep detection method may be a component of an implantable pulse generator such as a pacemaker or defibrillator.

Abstract: A non-invasive monitoring apparatus for end-tidal gas concentrations, and a method of use thereof, is described for the detection of endogenous gas concentrations, including respiratory gases, in exhaled breath.

Abstract: Systems and methods for quantifying the likelihood of the contribution of multiple possible forms of chronic disease to patient reported dyspnea can include the testing protocol having a flow/volume loop, performed at rest, flowed by the measurement of cardiopulmonary exercise gas exchange variables during rest, exercise and recovery as unique data sets. The data sets are analyzed using feature extraction steps to produce a pictorial image consisting of disease silos displaying the likelihood of the contribution of various chronic diseases to patient reported dyspnea. In some embodiments, the silos are split into subclass silos. In some embodiments, multiple chronic disease indexes are used to differentiate between sub-types of a particular chronic disease (e.g., differentiating WHO 1 PH from WHO 2 or WHO 3 PH). Test results are plotted serially to asses to provide feedback to the physician on the efficacy of therapy provided to the patient.

Abstract: Methods and devices for creating an artificial exhalation profile, for example for use in the sampling of exhaled breath or air from the nasal cavity from a mammal, wherein said mammal exhales into a device comprising a flow channel, a pressure sensor, a flow sensor, a control unit, and means for creating an exhalation flow, wherein said means for creating an exhalation flow maintain an exhalation flow at one or more pre-determined flow rate (rates), within a predetermined interval, substantially independent of exhalation pressure.

Abstract: An embodiment of an implantable system configured to be implanted in a patient includes an accelerometer, a neural stimulator, and a controller. The neural stimulator is configured to deliver neural stimulation to a neural target. The controller is configured to use the accelerometer to detect laryngeal vibration or coughing, and is configured to deliver a programmed neural stimulation therapy using the neural stimulator and using detected laryngeal vibration or detected coughing as an input to the programmed neural stimulation therapy.

Abstract: The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.

Abstract: The invention relates to a gas sampling device (100) for collecting gas samples from a patient or other gas sources such as industrial processes. The gas sampling device has a flow controller (114) and a flow sensor (112) for controlling a gasflow from the gas source created by a gas pump (113). The gas flow is pulled through an associated absorbent tube (180) located up-stream relative to the flow sensor and pump.

Abstract: The invention relates to an analysis method for determining a functional parameter of an organ of a human or animal individual by measuring the 13CO2 content in the air exhaled by the individual to which a substrate has been administered the reaction of which in the body of the individual enriches the air exhaled by the individual with 13CO2. The method is characterized by using a measuring device, the maximum reaction rate of the substrate in the body of the individual being determined via a change of the measured 13CO2 content in the air exhaled by the individual using zero-order enzyme kinetics. The invention also relates to an aqueous methacetin solution for use in said analysis method, the pH of the solution being greater 7.0. The invention also relates to a face mask (1) for use in the inventive method for separating the exhaled air from the air inhaled by an individual. Said face mask comprises a face mask body (2) and an air cushion (3) encircling the face mask body.

Abstract: An anti-fouling sleeve for an endotracheal tube, a method of placement, and the tools for placement. The anti-fouling sleeve occupies the entire length of endotracheal tube, and can be installed permanently or made removable and disposable. The sleeve may be instrumented with sensors and/or a UV light source to reduce and potentially eliminate biofilm formation. Once placed inside the endotracheal tube the sleeve expands to conform to the inner diameter of the tube. After use, any accumulated biofilm on the inner portion of the sleeve is removed leaving the inner portion of the endotracheal tube essentially sterile.

Abstract: Methods, systems, and devices are described for providing risk evaluation and mitigation strategies for use with modified risk products or other tobacco products, and in particular, associated with nicotine and tobacco products.

Abstract: An adaptor is adapted to be attached on a face of the subject to collect expiration gas of the subject. An airway case is formed with a chamber, and adapted to be coupled with a carbon dioxide sensor so that carbon dioxide in the expiration gas flowing through the chamber is detected by the carbon dioxide sensor. Nasal tubes are adapted to be inserted into nostrils of the subject when the adaptor is attached on the face of the subject. The nasal tubes are adapted to lead nasal expiration gas of the subject to the chamber. A mouth guide is adapted to lead oral expiration gas of the subject to the chamber when the adaptor is attached on the face of the subject. A branch tube is communicating with the nasal tubes and adapted to lead pressure generated by the nasal expiration gas to an external pressure sensor.

Abstract: A method, system and computer-readable medium are provided for determining compliance with one or more patient care rules and protocols, the method including the steps of sending infusion information from a pump to a processor pertaining to one or more drugs provided to a patient, sending ventilation information from a ventilator to the processor pertaining to ventilation provided to the patient and determining, with the processor, a variation between actual care of the patient and a set of rules and protocols associated with care of the patient at least in part based on the infusion information and the ventilation information.

Abstract: A first embodiment of a disclosed breath analyzer detects a particular breath component in a breath sample. The analyzer includes a housing defining an interior cavity and having an inlet aperture for receiving the breath sample and an outlet aperture. A sensor is disposed within the cavity for sensing the component of the breath sample. An anemometer circuit is associated with the sensor and measures a rate of flow of the breath sample within the housing. The analyzer further includes a controller operatively connected to the sensor to receive breath component information sensed by the sensor.

Abstract: A portable drug sampling device for handheldly collecting a sample from exhaled breath of a subject for further sensor based analysis. The device comprising: a housing (406) comprising at least one inlet (407) and at least one outlet (408) for the exhaled breath to exit through, and a sampling membrane (302) arranged in the housing. A tubular element (40) having a mouthpiece section (401) for the subject to exhale into, and a saliva trap section comprising baffles (103) to create a non-straight gas flow path for letting aerosols pass through the tubular element. The sampling membrane (302) is arranged to collect the aerosols from the exhaled breath. The portable drug testing device further comprises a volume collecting element (208).

Abstract: A cardiac rhythm management (CRM) device can extract ventilation information from thoracic impedance or other information, and adjust a delivery rate of the CRM therapy. A tidal volume of a patient is measured and used to adjust a ventilation rate response factor. The measured tidal volume can optionally be adjusted using a ventilation rate dependent adjustment factor. The ventilation rate response factor can also be adjusted using a maximum voluntary ventilation (MVV), an age predicted maximum heart rate, a resting heart rate, and a resting ventilation determined for the patient. In various examples, a global ventilation sensor rate response factor (for a population) can be programmed into the CRM device, and automatically tailored to be appropriate for a particular patient.

Abstract: An apparatus assesses a condition of a patient. The apparatus may contain a patient interface for communicating a treatment generated by a respiratory treatment apparatus to the respiratory system of a patient. The apparatus may also include a sensing module containing one or more electrochemical sensors to sense chemicals in exhaled breath in real time, or over an extended period of time. The apparatus may also include one or more collectors to accumulate a breath condensate over an extended period of time. The sample collectors may contain an absorbent material, and may also be adapted for replacement within a sensing module. The absorbent material may also include a preservative for preserving a chemical component of the breath, such as an analyte of the exhaled breath. The technology may provide treatment recommendations based on the detected condition of the breath condensate or the chemical components thereof.

Abstract: The invention is a drunkometer comprising a main body 10 and an alcohol sensor 20 provided in the main body 10 and detecting the concentration of the alcohol gas in the exhaled breath of the tested person, the drunkometer 10 further comprises a gas inlet port 21 provided on one side of the main body 10 and communicating with the alcohol sensor 20, into which a gas outlet port 53 of a portable standard gas cartridge 50 containing a standard alcohol gas with the predetermined concentration is detachably connectable, so that test or correction of the drunkometer should be carried out by connecting the gas outlet port 53 of the portable standard gas cartridge 50 into the gas inlet port 21 of the main body 10, detecting the alcoholic concentration of the standard gas cartridge 50 by the alcohol sensor 20 and comparing the detected value with that of the predetermined concentration of the portable standard gas cartridge 50.

Abstract: A device for measuring a component in exhaled breath comprising an inlet (32) for receiving exhaled breath, a buffer chamber (31). A first fluid conduit (34a) is in fluid connection with the inlet and adapted to lead a first portion (?) of the exhaled breath to the buffer chamber. The buffer chamber comprises an outlet (37) for discarding a first part of exhaled breath received from the first fluid conduit and the buffer chamber is configured to buffer a second part of exhaled breath received from the first fluid conduit. The device comprises a second fluid conduit (34b) in fluid connection with the inlet and adapted to lead a second portion (I?) of the exhaled breath to be discarded, and a sensor (63) for measuring a component in the exhaled breath buffered in the buffer chamber.

Abstract: A system for health and wellness mobile management comprises a database operable to store a health and wellness data record associated with a patient/data owner, a content management system adapted to strictly control access to the health and wellness data record stored in the database according to access rules set by the patient, a web interface adapted to interface with information requesters submitting requests for access to the health and wellness data record via a web application, an external connect interface adapted to interface with external systems and applications for receiving health and wellness data associated with the patient, a prescription interface adapted to receive a pharmaceutical prescription for the patient submitted by a healthcare provider, and a handheld physiological parameter measurement device adapted to wirelessly communicate with a computing device executing the web application.

Abstract: A portable electronic device for providing a plurality of operation modes, emits light to an object to be sensed via a light source and senses reflected light from the object to be sensed via an optical sensor to generate a sensing signal. Based on this sensing signal, various functions can be performed, for example, remote control, proximity sensing, gesture sensing, hear rate sensing, blood oxygen saturation sensing, exhaled gas alcohol concentration sensing. The portable electronic device provided by the present invention integrate various functions therein and can measure various kinds of physiological parameters, thus is more convenient and helpful for many users.

Abstract: A system and method for aiding in the diagnosis of a respiratory dysfunction is described. More particularly, a system and method for aiding in the diagnosis of one or more pulmonary embolisms is described. The system and method described herein include a plurality of sensors, a thermal control system, and a controller coupled to the plurality of sensors and the thermal control system for aiding in the diagnosis of a respiratory dysfunction.

Abstract: A peak flow meter, breathalyzer, and pulse oximeter for use with a mobile device, such as a smartphone, are disclosed. In one embodiment, the peak flow meter receives air flow from the patient, converts it into an electrical signal using a pressure transducer, and transmits the signal to a mobile device over an interface. In another embodiment, the microphone of the mobile device is used to directly receive the airflow, and the mobile device converts the airflow into an electrical signal indicating the peak flow. In another embodiment, a breathalyzer receives air flow from a patient, converts it into an electrical signal using a sensor, and transmits the signal to a mobile device over an interface. In another embodiment, a pulse oximeter measures oxygen saturation in a patient's blood and transmits an electrical signal for that measurement to a mobile device over an interface.

Abstract: A system and method are configured to monitor respiratory stability and/or effectiveness. A ventilation index is determined that provides an indication of respiratory stability and/or effectiveness. The ventilation index is determined from one or more metrics that indicate deviation of a breathing parameter of a subject from levels that have been observed to be normal or typical for the subject.

Abstract: Disclosed is a medical diagnostic device for analyzing breath gases and/or skin emissions, including a highly sensitive sensing component for obtaining an emission concentration profile and a database of breath analysis profiles medical condition characteristics.

Abstract: A breathing mask for ventilating a patient, the breathing mask includes a housing covering a respiratory passage of the patient, a first cavity surrounded at least partly by the housing conveying both an inspiratory and expiratory gas, a respiratory port delivering the inspiratory gas from the first cavity and the expiratory gas to the first cavity, and a sampling cell in flow communication with the first cavity, which sampling cell is adapted to convey both the inspiratory gas towards the respiratory port and the expiratory gas from the respiratory port, wherein the sampling cell includes at least one component for enabling a signal acquisition of at least one of the inspiratory and expiratory gas compound.

Abstract: Disclosed are methods, devices and compositions useful for providing evidence whether or not an intravascular conduit is correctly positioned in a blood vessel of a living subject, in some embodiments related to administration, through an intravascular conduit, of an indicator precursor such as bicarbonate, and monitoring for the presence of an indicator in the exhaled breath of the subject.

Abstract: The invention relates to an apparatus for the ventilatory anaesthesia of a patient by administration of a gas containing gaseous xenon that comprises a main gas circuit (CP) and a means for determining the xenon content (S6, M1) adapted for and capable of determining the gaseous xenon content in the main circuit (CP), and comprising at least one hot wire sensor (S6-E) including at least one electrically conducting wire (FC1) in direct contact with at least a portion of the xenon-containing gaseous flow.

Abstract: An endocapsule has a measurement chamber therein containing a sensor that detects at least one metabolic product of a specific bacterium in a hollow organ of a human or animal gastrointestinal tract. The endocapsule is introduced into the hollow organ wherein detection of the at least one metabolic product takes place.

Abstract: An airway device for use with deep sedation has a pair of conduits, one to supply oxygenated gas and the other to extract exhaled gas. The conduits are encompassed in a permeable sleeve with a stylet to facilitate positioning of the device in the airway.

Abstract: A method implemented, e.g., as software and a device operating according to the method for the automatic evaluation and analysis of a capnogram are provided. Measured values for an expired volume—volume measured values—and measured values for a carbon dioxide concentration—concentration measured values—are recorded for the breathing gas of a test subject. An automatic approximation of at least one part of the curve of the concentration measured values over the volume measured values is performed, by using three mutually adjacent straight lines for the approximation. The area is determined using the third straight line according to Fowler for the determination of the serial dead space Vds.

Abstract: Methods are disclosed for distinguishing whether an animal is experiencing a bacterial infection or a viral infection. One monitors breath taken from the animal over time to measure the relative amount of a first breath stable isotope to a second breath stable isotope therein over time. A quick change in the isotope ratios within several hours from the likely infection is indicative of a bacterial infection. A delayed change in the isotope ratios, followed by periodic repeated alterations in the ratios, is indicative of viral infection. The methods are particularly efficient when using cavity ringdown spectroscopy for the monitoring. They may be used for monitoring a patient already admitted to a hospital, or for monitoring a patient initially complaining of adverse symptoms, or for triage, or for collectively monitoring a population of animals.

Abstract: This disclosure provides gas monitoring apparatuses, methods and medical devices. A gas monitoring apparatus can include a gas concentration monitoring module, a respiratory mechanics monitoring module and a correction module. The correction module can determine a first correction value based on the gas ingredients and the gas concentration measured by the gas concentration monitoring module, so that the respiratory mechanics monitoring module can correct respiratory mechanics parameter(s) based on the first correction value. The correcting module can also determine a second correction value based on the pressure-related quantity measured by the respiratory mechanics monitoring module, so that the gas concentration monitoring module can correct gas concentration based on the second correction value.

Abstract: A health management device includes: a signal output unit which outputs a start signal indicating a start timing when application of an exercise load on a subject is started; an acetone detection unit which detects an acetone concentration in a biogas of the subject; a clock unit which measures time; a storage unit which stores the start signal and the acetone concentration outputted from the acetone detection unit together with the time; and a display unit which displays a first transition data group of the acetone concentration outputted from the acetone detection unit before the start signal is received, and a second transition data group of the acetone concentration outputted from the acetone detection unit after the start signal is received, based on an output from the storage unit.

Abstract: A device, system, and method for measuring acetone levels exhaled from a patient and correlating the measured level to a blood glucose concentration.

Abstract: The present invention provides a method for determining the presence and/or the level of drug in a subject's system using exhaled breath of the subject.