Abstract: Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more cooling elements is configured to be implantable, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.

Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.

Abstract: A medical and recreational device comprises at least two laminas. The laminas comprise sources of magnetic field. The sources of the magnetic field located on one of the laminas faced to another one completely or partially by like and/or unlike magnetic poles and at least one of said laminas configured to be attached to the treated body part.

Abstract: The invention relates to a biophysiological regulator for therapeutic treatments, including brain stimulation coils (7) which generate current using a microcontroller (11). The invention includes a second microcontroller (16), a liquid crystal display (17), a selector (21) for selecting pre-recorded programs and a connection port (20) for an external device (19) which is provided with a speaker (24) and LEDs that indicate whether or not the battery is charged (18), the regulator is connected (27), an application is underway (26) and the battery is low (25), and an internal program (28) which regulates the frequency and typology of the output wave and the time. The invention also includes a tamper protection system formed by a microcontroller (29) inside a special connector (30) built into the assembly (applicator and cable), in which the internal software of the device reads the serial number located inside the microcontroller of the connector.

Abstract: An apparatus for the treatment of chronic pain, through the use of an electro-magnetic field generated by the device. The apparatus comprises a frame with a continuous side wall and a central passageway extending there through with a bar disposed in the central passageway. The bar extends from one side of the continuous side wall the other side. Four pairs of identical planar pole magnets are embedded in the frame, and wherein each pair comprises two magnets which can have a planar face disposed adjacent the other and separated by less than 1 inch. A central magnet encircles the bar and can be disposed at the intersection of the donut-shaped low gauss magnet field wherein a central magnet is used for forming a substantially focused magnetic field.

Abstract: The provision of an potential therapeutic appliance for the delivery into living organisms of highly effective negative ions similar to those found in nature; and in particular, providing a special waveform shaping device that shapes the voltage waveforms delivered to electrodes to efficiently produce negative ions, that is capable of stable performance, and that can be easily manufactured. A waveform shaping device 3 charged with an inorganic insulating powder such as pumice stone powder and a predetermined volume of moisture is disposed in series between a high voltage power supply 2 and an output terminal 12; the current output from the negative terminal of the high voltage power supply is shaped by the waveform shaping device and then delivered to the output terminal; and in a repetitive process, the charge delivered from the high voltage power supply 2 is accumulated temporarily in a terminal 4 and discharged in a burst-like manner; thus facilitating convenient action of negative ions on the human body.

Abstract: A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells. In one embodiment, the method provides a synergetic effect with chemotherapy.

Abstract: A method and apparatus are disclosed which produce and detect quantum entanglement and non-local effects of substances on responsive targets such as biological systems. In one embodiment, the method includes the steps of providing two parts of a quantum-entangled medium, applying one part to a biological system such as a human, contacting the other part with a desired substance such as a medication or substance encoded with a message, and detecting change of a biological parameter with a detecting device, whereby a non-local effect of the substance on the said biological system is produced and detected for a beneficial purpose. Also described are a number of implementations.

Abstract: A cell excitation terminal and a therapeutic system using customized electromagnetic (EM) waves varying dynamically with time for excitation include one or more EM wave generators, each of the EM wave generators is connected to a central processing unit (CPU), and the CPU controls, according to a signal detected by a human body status detection device, the EM wave generator to send EM waves corresponding to a detected subject. The therapeutic system can perform remote management. A remote server optimizes and updates therapeutic waveforms of a patient constantly according to a therapeutic effect of the patient, thereby improving the therapeutic effect constantly.

Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.

Abstract: A method for implementing a low-frequency rotating constant high magnetic field is disclosed. The method includes disposing an even number of more than two high field magnets, and disposing a magnetically permeable rotating arm. The high field magnets are symmetrically and fixedly mounted on the same surface of the magnetically permeable rotating arm. Magnetic poles of free surfaces of two symmetrical high field magnets are opposite. The area of the free surface of the high field magnet is larger than that of a connecting surface. A cross section of the high field magnet is in a geometric shape without edges or corners. A rotating apparatus drives the magnetically permeable rotating arm and the high field magnets to rotate.

Abstract: A device for manipulating a magnetic coupling force across tissue in response to a monitored coupling force is described. The device includes a magnetic field source assembly, a positioning assembly operatively connected to the magnetic field force assembly, and a magnetic coupling force monitor. The magnetic field source assembly includes magnets that provide an external magnetic field source for providing a magnetic field across tissue. The positioning assembly adjusts the position of the magnetic field source. The magnetic field creates a magnetic coupling force between the external magnetic field source and an object positioned in use in a patient during a procedure, wherein the object has or is associated with an internal magnetic field.

Abstract: The treatment of specific neurological and psychiatric illnesses using Transcranial Magnetic Stimulation (TMS) requires that specific neuroanatomical structures are targeted using specific pulse parameters. Described herein are methods of positioning and powering TMS electromagnets to selectively stimulate a deep brain target region while minimizing the impact on non-target regions between the TMS electromagnet and the target. Use of these configurations may involve a combination of physical, spatial and/or temporal summation. Specific approaches to achieving temporal summation are detailed.

Abstract: The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.

Abstract: Methods and systems for modeling and displaying magnetic field intensities during Transcranial Magnetic Stimulation (TMS) are described, particularly methods and system for modeling and displaying TMS using overlapping magnetic fields to stimulate deep brain regions.

Abstract: Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat acute or chronic pain. The neuromodulation can produce acute effects or Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.

Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells with photoacoustic sound and nanoparticles.

Abstract: Various example embodiments are disclosed. According to one example embodiment, a magnetic therapy device may include a power source, a motor, a tachometer, and a microprocessor. The power source may be configured to supply power to the motor. The motor may be configured to control a disk upon which is mounted a plurality of magnets. The tachometer may be configured to monitor a magnetic field generated by the plurality of magnets and provide a signal to a microprocessor based on the monitored magnetic field. The microprocessor may be configured to control the motor based on the signal received from the tachometer.

Abstract: Disclosed are methods and systems and methods for neuromodulation of the Motor Cortex and other areas of the brain impacted by stroke. The neuromodulation can produce acute effects or result in Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, pulse duration, frequency, firing pattern, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. The invention can be applied for mitigating the effects of stroke and/or in stroke rehabilitation.

Abstract: Embodiments include applying or generating an alternating magnetic field near an affected area of a subject to be treated. When magnetic nanoparticles are located in the affected area, the magnetic nanoparticles are oscillated by the alternating magnetic field, which causes the magnetic nanoparticles to be dispersed within the affected area, break up the affected area, and/or heat the affected area.

Abstract: A method and apparatus are disclosed which produce quantum entanglement and non-local effects of various substances on responsive targets such as biological and/or chemical systems through quantum entanglement. In one broad embodiment, the apparatus includes a quantum entanglement generating source, said source emitting a plurality of quantum-entangling members such as photons when said source operates; and a substance disposed adjacent to said source, said substance being responsive to said members; such that when said source emits said members which pass through said substance and a biological system, said members first quantum-entangle with quantum entities in said substance, then travel to said biological system such as a human body and subsequently entangle with quantum entities inside the biological system producing non-local effect of the substance on said biological system through quantum entanglement.

Abstract: The inventive technique include a system, method and device for treating a patient. The inventive system includes a magnetic field generating device created using a powdered ferromagnetic. The system further includes a circuit in electrical communication with the magnetic core, and a power source in electrical communication with the circuit. The ferromagnetic powder core may be manufactured by at least one of the following: machining, pressing, molding, gluing, and extruding. Also, the ferromagnetic powder core may have a distributed gap structure, where the gap structure operates to focus the magnetic field between pole faces of the magnetic device.

Abstract: The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, flat surface incident magnetic field surfaces, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract: The invention is directed to a novel method for reducing discomfort caused by transcutaneous stimulation. The novel method includes providing transcutaneous stimulation, reducing the transcutaneous stimulation at a first location, and substantially maintaining the transcutaneous stimulation at a second location. The transcutaneous stimulation may be created by electric and/or magnetic fields. The first location may be relatively proximate to the cutaneous surface and may comprise tissue, nerves and muscle. Also, the second location may be relatively deeper than the first location and include, for example, brain tissue that requires the transcutaneous stimulation for treatment purposes. The invention further may include locating a conductor on a treatment area and/or a transcutaneous stimulation device relative to the first location. In addition, the method may further include adjusting how much the transcutaneous stimulation is reduced at the first location.

Abstract: The present invention relates to a method for treatment and/or prevention of diseases and functional disorders of external genital organs and a device for realizing the same. The method comprises exposure of an organ to periodic action of vacuum and/or mechanical oscillations and low-frequency pulsed magnetic field and is characterized in that the organ is additionally exposed to a light field and the light exposure of different wavelengths is combined. One of the embodiments of the device for realizing the method comprises a source of mechanical oscillations with a periodic controlling device, an isolated chamber adapted to accommodate a to-be-exposed organ therein, a source of a low-frequency pulsed magnetic field with an inductor generating a magnetic field in the place of location of the organ to be subjected to exposure.

Abstract: The present invention relates to a latent neural stem cell population which is capable of activation by membrane depolarization of a neural cell population, isolation and culture of same, and uses thereof.

Abstract: A device of guiding a multiple area dermatologic care process. The device comprises a carrier which supports a drive of a dermatologic care tool over a skin area while the dermatologic care tool intermittently performs a plurality of dermatologic care sessions each in one of a plurality of skin subareas of the skin area and a brake unit which regulates a movement of the carrier from a first skin subarea to a second skin subarea during the drive of the dermatologic care tool.

Abstract: Systems and methods for removing plaque from blood vessels by applying constant or time varying magnetic or electrical fields. In one embodiment a system includes winding configurations positioned about a central axis along which a body region may be placed. Each winding configuration generates a magnetic field in a direction which passes through the body region. A first winding configuration generates a first magnetic field component perpendicular to a second magnetic field component generated by a second winding configuration. In a related method for removing a deposit of plaque from a position along a wall of a blood vessel a magnetic field is applied which has a net direction predominantly orthogonal to the direction of the flow of blood through the vessel.

Abstract: The Invasive Agent Treatment System incorporates the pairing of energy fields with nano-particles to cause a thermal effect in the nano-particles, which thermal effect is transmitted into the biological cells of the invasive agent. The energy fields are derived from at least one or a combination of the following: an electric field, a magnetic field, an electromagnetic field (EM), an acoustic field, and an optical field. The Invasive Agent Treatment System provides the necessary coordination among the characteristics of the nano-particles, concentration of nano-particles, duration of treatment, and applied fields to enable the generation of precisely crafted fields and their application in a mode and manner to be effective with a high degree of accuracy.

Abstract: An acupuncture needle having a low magnetized or non magnetized needle shaft or shank portion and a magnetic or magnetized handle portion to deliver both penetration and magnetic treatment to an acupuncture point.

Abstract: Apparatuses, compositions and methods for removing cells which interfere with regenerative processes. The apparatuses, compositions and methods selectively kill partially functional and/or non-functional cells versus functional cells while protecting functional proliferative cells to the extent that, upon removal of the killed cells by disintegration or scavenging, functional cells replace the partially- or non-functional cells.

Abstract: Systems, devices, methods, and compositions are described for providing an actively controllable shunt configured to, for example, monitor, treat, or prevent an infection.

Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Abstract: A system (100) including a catheter mounted magneto sensor (114), such as a superconducting quantum interference device (SQUID), and methods using the system are disclosed, where the system and method are designed to detect changes in a magnetic field in a body of interest, such as a patient, to detect changes in a magnetic field in a patient, to identify loci in a target body that accumulate magnetic particles or to identify vulnerable plague in a patient.

Abstract: Provided herein are biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided including electronic devices useful for establishing in situ conformal contact with a tissue in a biological environment. The invention includes implantable electronic devices and devices administered to the surfaces(s) of a target tissue, for example, for obtaining electrophysiology data from a tissue such as cardiac, brain tissue or skin.

Abstract: Provided is a magnetic stimulator for applying magnetic stimulation to a particular portion of a subject. This magnetic stimulator includes: a magnetic field generating means including at least a stimulation coil configured to generate a dynamic magnetic field so as to apply the magnetic stimulation; a coil holder operated to displace a relative position of the magnetic field generating means with respect to the particular portion of the subject; a plurality of magnetic field sensors each configured to detect the magnetic field generated by the magnetic field generating means; and a user interface section configured to provide instruction information based on a result of the detection of the magnetic field generated by the magnetic field generating means, the instruction information indicating an operation of displacement to be performed using the coil holder, the detection being made by the magnetic field sensors either before or during the magnetic stimulation.

Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

Abstract: A method and morphologically adaptable apparatus for altering the charge distribution upon living membranes is provided. The method and apparatus further provides a static magnetic device for production of a magnetic field for treatment of various disorders that can be focused at the site of pain or edema to deliver a gradient in the magnetic field to prevent or reduce charge flow. Further there is provided a static magnetic device for production of a magnetic field for treatment of disorders wherein the device provides a static magnetic field such that the focused magnetic field gradient is oriented to be perpendicular to the neuron or membrane charge flow providing maximum deflection of the ion or charge flow.

Abstract: A catheter (100) having a catheter body (102) having a proximal end (106) and a distal end (104) and a proximal portion fixedly connected to the proximal end. A magnet (120,220,320) is disposed around the catheter body (112) distally of the proximal portion and may be contained within a hub (208, 308).

Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue applies a heat source to kill cells without protein denaturation. The hyperthermia treatment may further comprise platelet-derived treatment. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. The temperature to which the target site is treated ranges from about 39° C. to about 58° C., and may last from about 5 seconds to about 30 minutes. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream to flow through the target site.

Abstract: A housing apparatus includes housing units in which a plurality of permanent magnets are housed, respectively; binding units which are arranged in the housing units, respectively, and bind the permanent magnets in the housing units, respectively; permanent magnet detectors which are arranged in the housing units, respectively, and detect whether the permanent magnets are housed in the housing units, respectively; and a control unit which controls the binding units to selectively keep the permanent magnets in a binding state or a nonbinding state on the basis of detection results of the permanent magnet detectors.

Abstract: The present invention relates to an apparatus and method for improving the delivery of desirable substances across a membrane utilizing a varying electromagnetic energisation profile. More particularly, the invention provides methods for modifying the cellular environment of such membranes and the behaviour of substance molecules during transport across a membrane. In use, the profile will have application in, enhancing transmembrane delivery of substances (such as pharmaceuticals, nutraceuticals, biopharmaceuticals and cosmeceuticals), and/or enhancing or expanding a cellular cohort of membranes and surrounding tissues.

Abstract: Techniques for applying torque to microscopic paramagnetic structures in a body includes exposing a body simultaneously to a first magnetic field oscillating at a first frequency in a first direction and a different second magnetic field oscillating at a second frequency in a second direction. The body includes a plurality of microscopic paramagnetic structures for which magnetic susceptibility to the first magnetic field is different from magnetic susceptibility to the second magnetic field. Such techniques are effective for ameliorating a symptom of a disease in an animal in which disease agents or diseased cells selectively include microscopic paramagnetic structures, including malaria.

Abstract: A brush with magnetic filaments is described. The brush may be used, for example, as a brush for applying a cosmetic material. The filaments of the brush may, in one example, be made of a synthetic material infused with magnetic material.

Abstract: This invention describes a system for generating multiple simultaneous tunable electron and photon beams and monochromatic x-rays for all field simultaneous radiation therapy (AFSRT), tumor specific AFSRT and screening for concealed elements worn on to the body or contained in a container. Inverse Compton scattering renders variable energy spent electron and tunable monochromatic x-rays. It's spent electron beam is reused for radiation with electron beam or to generate photon beam. Tumor specific radiation with Auger transformation radiation is facilitated by exposing high affinity tumor bound heavy elements with external monochromatic x-rays. Heavy elements like directly iodinated steroid molecule that has high affinity binding to estrogen receptor in breast cancer and to iodinated testosterone in prostate cancer or with directly implanted nanoparticles into the tumor are exposed with tuned external monochromatic x-rays for tumor specific radiation therapy.

Abstract: A system for treating patients includes a first magnetic device including a set of four magnetic discs arranged in a square array, the four magnetic discs including two having negative magnetic poles lying in a first plane and two having positive magnetic poles lying in the first plane, wherein the two magnetic discs having negative magnetic poles extend along a first diagonal line and the two magnetic discs having positive magnetic poles extend along a second diagonal line that crosses the first diagonal line, and a housing containing the four magnetic discs for maintaining the magnetic discs in the square array arrangement, the housing including an alignment marker for aligning the first magnetic device on a patient.

Abstract: Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of treating lower urinary tract disorders using energy that is delivered noninvasively by the devices. The disorders comprise overactive bladder, urge incontinence, stress, incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. In preferred embodiments of the disclosed methods, a posterior tibial nerve of a patient is stimulated non-invasively. Methods are disclosed for selecting protocol parameters for a nerve stimulation session for treating each individual patient, wherein modules of the bladder of the patient are represented as coupled non-linear oscillators.

Abstract: Methods, systems, and apparatus are disclosed to provide treatment to patient tissue using medical hardware incorporating magnetic material. Methods, systems, and apparatus are disclosed to provide magnetic induction heating of cells at a tissue site in a patient.

Abstract: Effective devices and methods using an antifibrotic agent are provided for treating fibrosis or treating normal fibrous tissue. The devices and methods comprise an antifibrotic agent to degrade shrink, relax or stretch at least a portion of the fibrotic tissue. In some embodiments, the methods and devices are configured to immediately release an effective amount of the antifibrotic agent within 24 hours. In some embodiments, when the device comes in contact directly or indirectly with an activator, the antifibrotic agent will be immediately released from the depot. In some embodiments, the depot provides sustained release of the antifibrotic agent over a period of up to one year to treat fibrous tissue.

Abstract: A method of analyzing a blood-brain bather of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations.