Abstract: The present invention describes compounds comprising at least one structural element having at least three fused aromatic or heteroaromatic rings (AR) and at least one structural element having an aromatic or heteroaromatic valerolactam (AV), especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.

Abstract: An article, such as a tissue bonding article, includes a flexible material, a polymerization initiator or rate modifier disposed in or on the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material, where the polymerization initiator or rate modifier is a polymerization initiator or rate modifier for the polymerizable adhesive composition.

Abstract: In one embodiment, the present invention provides a composition, wherein the composition is a porous scaffold, wherein the pores of the scaffold are from 2 to 500 microns, the composition comprising: a) a cross-linkable protein selected from the group consisting of collagen and gelatin; b) a cross-linker which induces cross-linking of the cross-linkable protein; and c) a liquid.

Abstract: A tissue bonding article includes a flexible material, an adhesive substance applied over at least a portion of a bottom side of the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material.

Abstract: An article includes a non-tacky cured silicone first layer, an optional foamed material and a tacky cured silicone second layer wherein the first layer is directly bound to the second layer and the article is conformable to a body part. The article removably adheres to a body part. Also described is a method of making the article.

Abstract: A topical solubilized ivermectin pharmaceutical composition for the treatment and/or prevention of inflammatory skin conditions is disclosed herein. The topical solubilized ivermectin pharmaceutical composition comprises an ivermectin and a cyclodextrin. Particularly, ivermectin is combined with cyclodextrin to form an ivermectin-cyclodextrin complex solubilized in a Tween80-water solution up to a 30% by weight of solution. The present invention features a formulation of Ivermectin-cyclodextrin complex solubilized in a Tween80-water solution incorporated into lotion or cream or gel base that is highly effective in the treatment inflammatory skin conditions at a concentration of, in some embodiments, 0.125% to 5% ivermectin by weight.

Abstract: A dressing for treating tissue with negative pressure is provided herein comprising a composite of dressing layers, including a release film, a perforated coated polymer film, a manifold, and an adhesive cover. Additionally, a method of manufacturing the dressing may comprise applying a cross-linkable polymer to a polymer film, curing the cross-linkable polymer to a gel layer to form a coated polymer film, and perforating the coated polymer film to form fluid restrictions, such as slits and/or slots, though the coated polymer film.

Abstract: Compositions and methods for reducing the symptoms of skin conditions associated with the nail and surrounding tissue are provided. A medicated pad for cleaning and treating the nail and surrounding tissue is described, wherein said pad is saturated with a therapeutic composition comprising certain botanicals, an antimicrobial agent, a surfactant, and a moisturizing agent. The skin and nail conditions can include fungal infections of the nails. Kits for treating fungal infections of the nails are likewise described. Optionally, the kit may include a hydrating composition which includes shea butter, aloe, vitamins, arnica, emu oil, urea, and Vitamins C, A, E, and D. A bandage comprising a therapeutic pad instilled with an antifungal agent is also provided.

Abstract: Items that adhere to the skin for medical or paramedical use and methods of making and using the same are described.

Abstract: A medical polymer device comprising a biodegradable polymer is provided, wherein the biodegradable polymer has a crystallinity of about 10% to about 80%, and preferably from about 20% to about 60%, wherein the medical polymer device comprises a small molecule organic compound which diffuses into the biodegradable polymer, the small molecule organic compound has a molecular weight of from about 100 to about 1000 Daltons, preferably from about 150 to about 500 Daltons, and more preferably from about 150 to about 250 Daltons, and the small molecule organic compound is non-evaporating or low-evaporating. The present invention also provides a method for preparing a medical polymer device according to the present invention as well as a method for modifying a medical polymer device made from a biodegradable polymer.

Abstract: The present invention provides a transdermal patch including: a backing layer; a drug-containing adhesive layer including rivastigmine or a pharmaceutically acceptable salt thereof and two kinds of skin penetration enhancers; and a release liner; wherein the drug-containing adhesive layer is disposed between the backing layer and the release liner; a content of rivastigmine or the pharmaceutically acceptable salt thereof is between 10 wt % and 30 wt % based on a total weight of the drug-containing adhesive layer; and the adhesive includes a pressure sensitive adhesive.

Abstract: A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to be placed over the wound. The bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.

Abstract: The invention provides a dry biocompatible film comprising at least one film forming material and particulate egg shell membrane (ESM), wherein said particulate ESM is distributed substantially uniformly in and/or on the film and wherein said film, or portion thereof, disintegrates upon contact with a wound or an exudate thereof. The invention further provides methods for preparing the films of the invention and the uses thereof in methods to promote the healing of wounds.

Abstract: Systems and methods for delivering a foamed fluid to a wound of a patient (e.g., through a wound dressing covering the wound and coupled to the skin around the wound).

Abstract: Embodiments disclosed herein provide compositions, methods, and uses for treating skin wounds, including chronic wounds such as venous ulcers. Certain embodiments provide methods for treating a skin wound, where the entire wound is exposed to zinc, especially in the form of zinc gauze. Certain embodiments provide methods for treating a skin wound, where only a peripheral rim of the wound is exposed to zinc, especially in the form of zinc oxide gauze. Other embodiments provide wound dressings and wound dressing kits, where the dressing and dressing kits include central gauze free of zinc to contact a central drainage zone of the wound and a second zinc gauze to contact a peripheral healing zone of the wound. In certain embodiments, the central gauze is optional.

Abstract: A system for reducing the damaging effects of radiant energy, blast, or concussive events includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during or before the incidence of the imparting event. Reducing blood outflow from the cranial cavity increases intracranial volume and/or pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood outflow further increases the intracranial pressure and volume, and thereby increases the pressure and volume of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure and volume reduces the likelihood of brain injury and any associated loss of olfactory function.

Abstract: Provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase.

Abstract: The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for grafting to a patient. In applying the method and/or in using the device, donor tissue is harvested, subjected to a cell dissociation treatment, cells suitable for grafting back to a patient are collected and dispersed in a solution that is suitable for immediate dispersion over the recipient graft site.

Abstract: The present disclosure relates to surgical grafts for replacing nipples and areolas lost to disease or trauma with surgical grafts of decellularized donor nipples and areolas and to placing and recellularizing such grafts. The disclosure further provides methods for decellularizing epidermis. The decellularized epidermis can be used as a protective cover for skin wounds.

Abstract: A heating tool (100) according to the present invention includes a steam generator (10) that a heat generating layer (11) which contains an oxidizable metal, a carbon component, a water absorbent polymer, and water, and a water absorbent sheet (102) which carries water are laminated, and a bag (20) at least a portion of which has an air permeability and accommodates the steam generator (10), in which a mass ratio of the water absorbent sheet (102) is equal to or greater than 0.9 and equal to or less than 15 with respect to the water absorbent polymer contained in the heat generating layer (11).

Abstract: A nonwoven fabric includes fibers of a fiber raw material including gelatin, the fibers including at least one of an antimicrobially effective substance and an antibiotic, wherein the fibers are produced by rotational spinning.

Abstract: A laminated graft fabricated from human birth tissue material comprising at least two amniotic membranes, or at least two chorionic membranes, or at least one amniotic membrane and at least one chorionic membrane, and at least one morselized placental composition to form a human birth tissue laminate graft. Methods of processing human birth tissue material to form a laminated graft are also provided. Additionally, methods for treating a wound or defect and methods of promoting regeneration of diseased or damaged tissue are provided.

Abstract: There is provided a method for reducing microbial load at a site on the skin of a subject. The method comprises applying a dressing over the site on the skin of the subject at which a medical procedure that involves breaching the skin is to be performed. As used in the method, the dressing comprises a self-adhesive silicone gel sheet comprising at least about 95 wt % silicone and up to about 5 wt % of particulates of an antimicrobial dispersed in the silicone. The dressing is applied with the silicone gel sheet contacting the skin of the subject and is left in place to allow the antimicrobial to diffuse onto the site.

Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.

Abstract: A medicinal product (10) is for the care of an individual having at least one injury such as a burn wound or a skin abrasion, in particular with a large surface area. The product includes at least one functional surface (12, 12?, 14) to at least partially cover the injury and/or to fix the medicinal product (10) to the individual. At least one functional surface (12, 12?) includes stem parts (18) protruding from the surface. The free end-faces of the stem parts form an adhesion section able to adhere at least partially to the individual and/or to a further functional surface (12?), predominantly by Van der Waals forces.

Abstract: The invention relates to porous absorbent Composite Material, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides a hydrophilic Self-Dispersive, fragmentable and Bio-Absorbable Porous Composite foams, suitable for packing antrum or other cavities of the body, comprising of composite of polymers, which polymer preferably comprises —C(O)—O—; NH2/3+; —OH; —CH2OCH2C(O)O— groups as functional or —CH—O— (e.g. C2H4O; C6H10O5; C6H8O6); —CH—N—O— (e.g. C8H13NO5); O—C—C— (e.g. O—CH2-CH2); —C(O)N— groups in the backbone of the polymers e.g. gelatin, chitosan, collagen, alginate, polyvinyl alcohol, polyethylene glycol, keratin, cellulose.

Abstract: Robotic debridement apparatuses, related systems, and methods of using the same are disclosed herein. The robotic debridement apparatuses are configured to facilitate debridement of tissue from a body region. For example, the robotic debridement apparatuses can include one or more of at least one debriding tool configured to debride tissue, at least one debris disposal device configured to capture substances in the body region. The systems disclosed herein can include a plurality of robotic debridement apparatuses. The systems disclosed herein can include a dressing associated with the plurality of robotic debridement apparatuses. The dressing can be associated with the robotic debridement apparatuses in a manner that facilitates operations of the robotic debridement apparatuses.

Abstract: A wound care product in the form of a gel is provided, and contains protein from egg shell membrane. The gel is made by first hydrating the egg shell membrane powder and then adding carbomer to partially neutralize the egg shell membrane. The neutralization is completed with the addition of triethanolamine, so as to form a homogeneous gel with a smooth consistency. An antimicrobial compound and a tissue growth accelerator are added to the gel. The gel, infused with egg shell membrane, is applied directly to the wound tissue to form a barrier trapping the active ingredients adjacent the wound site and inhibiting penetration of outside bacteria into the wound site.

Abstract: The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for grafting to a patient. In applying the method and/or in using the device, donor tissue is harvested, subjected to a cell dissociation treatment, cells suitable for grafting back to a patient are collected and dispersed in a solution that is suitable for immediate dispersion over the recipient graft site.

Abstract: An interface component is provided for use with a first glove and a medical equipment component. The interface component comprises at least one switch located on the first glove, where each of the at least one switch provides a control signal to the medical equipment component. The interface component may further comprise a controller coupled to the plurality of switches, a power supply module coupled to the controller, and a wireless communications interface coupled to the controller in communication with a wireless interface of the medical equipment component.

Abstract: A limb protective covering (10) includes an elongated sleeve (11) and an adjustable, elastic retaining strap (12). The sleeve has a closed end (15) and an open end (16) opposite the closed end. The sleeve is made of a high performance elastomeric polymer blend, such as a styrene-butadiene-styrene (SBS) based monolayer elastomeric antistatic film having a coefficient of friction of at least 0.6.

Abstract: A pad for electrically stimulated wound healing, including a pad configured to be placed on a wound, at least one anode disposed on the pad to contact the wound, and at least one cathode disposed on the pad to contact the wound, the at least one cathode being disposed separately from the at least on anode. The pad wherein the at least one anode and the at least one cathode in contact with the wound provide a flow of electrical current in an intended direction through the wound based on the separate locations of the at least one anode and the at least one cathode.

Abstract: Disclosed herein is a method of attaching a medical device to a surface, the medical device having at least one adhesive area, wherein the method comprises the steps of: contacting the surface with a composition comprising a T silicone resin and/or a DT silicone resin and/or an MQ silicone resin and/or an MT silicone resin, thereby providing non-tacky coating on the surface; and attaching the adhesive area to the surface such that the composition is located between, and in contact with, the surface and the adhesive area, thereby attaching medical device to the surface; thereby achieving an improve adherence between the medical device and the surface.

Abstract: A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.

Abstract: Sheet for cutaneous application comprising a support layer made of loosely woven fabric embedded in a layer of silicone elastomer incorporating vitamin E or an ester thereof, wherein the layer of silicone elastomer has a thickness less than or equal to 2.0 mm and the silicone elastomer contains an elasticity modifier consisting of a triglyceride of saturated C8-C18 fatty acids.

Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using ?-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using ?-irradiation, treating under a nitrogen plasma, or both.

Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

Abstract: The present disclosure is drawn to methods for treating various types of pain. Specifically, a method for treating various types of pain includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36° C. to 42° C.

Abstract: The present disclosure is drawn to methods for treating various types of pain, including pain associated nerve entrapment, neuroma, headaches, connective tissue, arthritis, injury, and/or overuse. Specifically, the method includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for an application period of at least 30 minutes. Following the application period the analgesic system can be removed and the subject being treated continues to experience reduction of pain for a period of 2 to 10, or even 4 to 12 hours after removal of the analgesic system. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation.

Abstract: The various embodiments herein provide an electro spun wound dressing comprising three nano fibrous layers and a method of synthesizing the same. The outer polymeric layer acts as a support layer for the other two layers and is hydrophilic in nature. The middle layer comprises a genipin cross linked reservoir layer loaded with a herbal extract of Melilotus officinalis and is hydrophobic or hydrophilic in nature. The second layer is cross-linked to control a release of the Melilotus officinalis extract in an aqueous environment. The third layer is a wound contacting inner layer comprising a non-cross-linked chitosan based nanofibrous layer that is hydrophilic in nature. Various additives are provided to enhance the mechanical or the chemical properties of the wound dressing and to control a release profile of the herbal extract.

Abstract: A system for applying a reduced pressure at a tissue site includes a reduced pressure source, a porous pad in fluid communication with the reduced pressure source, and a drape positionable over the porous pad to seal the porous pad at the tissue site. The porous pad includes a plurality of channel walls to form a plurality of channels between the channel walls. The channel walls are substantially liquid impermeable to prevent movement of a liquid through the channel walls but are gas permeable to allow movement of a gas through the channel walls as reduced pressure is applied at the tissue site. The liquid impermeability of the channel walls and the application of reduced pressure causes flow of the liquid to occur through the plurality of channels.

Abstract: An elongate adhesive article having a length substantially greater than a width includes a backing layer having an adhesive layer and a single weakened region formed of a removable strip of backing layer that is oriented substantially perpendicular to the article length. The removable strip of backing layer is at least partially defined by a pair of lines of weakness separated by a gap of between about 2 and about 15 mm. The elongate article may include an absorbent pad in the form of an adhesive bandage or sticking plaster. A method of using such an elongate article includes the steps of applying the article to the skin of a mammal, removing a predefined strip from the article; and removing the remainder of the article from the skin.

Abstract: Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin, wherein the thrombin is present in an amount between 0.250 Units/mg of fibrinogen component and 0.062 Units/mg of fibrinogen component. Also disclosed are methods for treating wounded tissue.

Abstract: A bandage includes a reservoir filled with a perfluorochemical fluid, saturated with oxygen. Oxygen passes through a permeable membrane to the skin or wound to promote healing, and carbon dioxide travels from the skin or wound to the reservoir.

Abstract: Fibrous antimicrobial materials for use in structures and barrier applications, such as face masks and wound dressings, have been developed from antimicrobial polymeric materials. The fibrous antimicrobial materials also are particularly suitable for use in air and water filtration. The antimicrobial polymeric materials are prepared from solid solutions of antimicrobial bisguanide compounds blended with certain thermoplastic polymers. The antimicrobial polymeric materials may be extruded into fibers or used in the particulate form for preparation of the nonwoven antimicrobial materials. The antimicrobial bisguanide compound, such as chlorhexidine, are distributed at the molecular level within at least one thermoplastic polymer, such as a polyolefin in which the antimicrobial bisguanide compound is soluble, to form a miscible blend. Methods for their formation and use also are provided.

Abstract: A wound dressing for covering a wound is formed of at least one absorbing member and a plurality of elongated activated carbon fibers. The at least one absorbing member is made of a foamed polymeric material and includes a plurality of pores. The activated carbon fibers are distributed in the at least one absorbing member and partially protrude into the pores. Each of the activated carbon fibers has a diameter of 2-15 ?m and a length of 40-1500 ?m. In light of the above, the tissue fluid leaking from the wound can be absorbed by the absorbing member to prevent the wound from soakage and the activated carbon fibers inside the absorbing member can emit far-infrared rays to promote the blood circulation around the wound for quickening healing of the wound.

Abstract: A device for the dressing of wounds and insertion sites of percutaneous and drug delivery devices provides 360 degree or complete circumferential protection of a wound or insertion site of a percutaneous or drug delivery device. In particular, the device is an integrated dressing for catheters comprising a pad and an adhesive dressing.

Abstract: A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may for example be an aniline or acridine dye.

Abstract: A wound dressing and a method of making the wound dressing is described herein. The wound dressing is formed of an absorbent substrate formed of one or more layers and a low-adherence layer disposed on the substrate. The low-adherence layer can be disposed within at least a portion of the substrate. The low-adherence layer is formed of a mixture of at least one highly fluorinated polymer and at least one acidic polymer. The at least one highly fluorinated polymer has a fluorine content greater than the fluorine content of the at least one acidic polymer.

Abstract: Devices in which components of medical kits are carried are identifiable by means other than by the naked eye. The means for identification is attached to or integral with the device and may comprise raised and lowered surfaces that can be read by touch; serrations disposed on an edge or surface; a fluorescent coating viewable under infrared or ultraviolet light; or a pattern that is viewable using a thermal imaging device such as night vision goggles. A package for retaining a medical item includes an identifying element of a material that is selectively viewable in response to light attributes of the material. A device for the visual identification of a package containing a medical item includes an identifying element comprising a material that is visually discernible in reduced-light environments via the use of night vision devices.