Abstract: A medical device (10) configured for attachment to skin of a patient includes a vital sign sensor or drug delivery patch (14); and a plurality of suction cells (12) arranged around a periphery of the vital sign sensor or drug delivery patch.

Abstract: A solid dose for insertion into the skin of a patient wherein the solid dose has a hollow core. There is also provided a solid dose carrier, a device, a method of manufacturing the solid dose and a method of delivering a solid dose transdermally to a human or animal.

Abstract: An assistive device for subcutaneous injections or implants. The assistive device is placed under a blood pressure cuff that displaces the skin and subcutaneous tissues of a patient at an insertion site in order to allow guided insertion of a needle or implant applicator into a subcutaneous fat layer. The skin and subcutaneous tissue is displaced or drawn, via pressure applied by the blood pressure cuff, through an injection window of a device body into a hollow cavity of the device body. A guide channel leads from a front side of the device body into the hollow cavity, and an applicator of an adapter is inserted through the guide channel into the subcutaneous fat layer.

Abstract: An injection device is disclosed which comprises a housing (140, 240, 440, 740) for a plurality of cartridges (110,310,410,810) each containing a medicament to be administered to a patient. A plurality of needles (120, 220, 320, 420, 720, 820) may be provided in communication with the plurality of cartridges. A delivery mechanism is arranged to deliver medicament through the plurality of cartridges via the plurality of needles. An injection device may comprise a drive member (130) having a cam surface (136) configured to engage a surface of a carrier (150) and rotate the carrier about a pivot (152) and at least one plunger (134) arranged to engage a cylinder in the cartridge.

Abstract: The present invention relates to a rectal delivery device in the form of a syringe with improved locking mechanism for the delivery of an appropriate dosage of a medicament, thereby minimizing errors. More particularly, the present invention provides syringes with improved lock control units for delivering diazepam formulations for the treatment of patients experiencing epileptic seizures.

Abstract: The present invention describes a mouse tail vessel injection device. The device consists of a ring situated on top of a platform, which is attached to a tourniquet, and includes a tool to place the device on and off the tail of the mouse. The ring allows access to the lumen of the tail vessel by providing the appropriate angle and width for the needle gauge. The placement tool contains 3 adjustable prongs which insert into the retainer holes attached to the tourniquet, thus allowing expansion and contraction of the tourniquet to move the device on and off the tail.

Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

Abstract: An applicator for dispensing a liquid, the applicator including: a body, a holder for holding a supply of liquid to be dispensed, a nozzle mounted on the body for dispensing the liquid, an elongate priming chamber within the body for receiving liquid from the holder, an elongate delivery chamber within the body for receiving liquid from the priming chamber, a piston assembly having a piston located in the delivery chamber and being moveable in a first direction to draw liquid from the priming chamber into the delivery chamber and in a second opposite direction for passing liquid from the delivery chamber to the nozzle, a drive arrangement capable of effecting incremental movement of the piston in the second direction for metered dispense of the liquid, and a first actuator for operating the drive arrangement for effecting the incremental movement.

Abstract: An appliance for vaginal penetration includes a grip, the appliance being designed to receive a working tool, especially an insemination gun that passes through the grip. A guiding tube extends the grip in order to form a compact assembly, the guiding tube being designed so as to receive the front tip of the working tool therein and receiving a video viewing device such as an endoscopy-type tube including a lighting element on the front end thereof, the appliance for vaginal penetration including an electronic cell receiving the video images, provided with a device for transmitting images to a remote screen.

Abstract: A forceps includes a handle, a shaft having a proximal end coupled to the handle, and an end effector assembly coupled to a distal end of the shaft. The forceps includes a first jaw member and a second jaw member for grasping tissue therebetween. One or both of the first and second jaw members may include one or more needles extending therefrom. The one or more needles are in fluid communication with a fluid conduit extending along one or both of the first and second jaw members. The fluid conduit couples to a source of contrast agent to enable selective delivery of the contrast agent through the one or more needles.

Abstract: A novel medical device and a method for delivery of a scaffold for treatment of secondary lymphedema and ischemia is provided. In some embodiments a catheter medical device and a magnetic guidance method are provided for delivering cell-seeded implants for guided lymphatic regeneration.

Abstract: Pericardial modification devices and methods can be used for the treatment of heart conditions. For example, this document describes devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure. In one example embodiment, a method for treating diastolic heart failure includes creating an opening in a patient's pericardial tissue, or removing a portion of the patient's pericardial tissue. The creation of the opening or the removing of the pericardial tissue reduces pressure exerted by the pericardial tissue on the patient's heart. The pericardial modification procedures are performed while avoiding trauma to the epicardial surface of heart as well as the phrenic nerves.

Abstract: A medical fluid injector is connected to a supply tube through which medical fluid is supplied and a discharge tube through which the medical fluid is discharged. The medical fluid injector has a housing body and a reservoir module which is disposed within the housing body. The housing body has a grip portion, which has a length in the longitudinal direction that is greater than a width in a direction orthogonal to the longitudinal direction, and a pair of button protection arms located at one end adjacent to the grip portion. The reservoir module has a reservoir bag, which stores and discharges the medical fluid, and a push button which pushes the reservoir bag to discharge the medical fluid in the reservoir bag. The reservoir bag is fluidically connected to the supply tube and the discharge tube. A portion of the push button is positioned between the button protection arms.

Abstract: Needle devices are described. The needle devices can have a catheter hub, a needle hub, and a valve system for controlling fluid flow through the catheter hub. The valve system can include a valve and a valve retainer. The valve can have flow holes for fluid flow therethrough or can have a valve piece for controlling flow through flow holes located externally of the valve. A needle guard is usable with the needle device to block a tip of the needle. A valve opener can also be used to open the valve.

Abstract: A safety needle device having a housing, a retractable sheath, and a needle cannula. The retractable sheath includes a tubular portion that is slideably mounted about a portion of the housing to completely or partially encase the length of the cannula. The retractable sheath includes a sheath bevel at the distal end having a blunted or angled tip. The angled tip being configured to suitable injection angles and may be fixed or rotatable. The sheath bevel may include a skin-engaging contact surface at the distal end. The needle may be connected to a needle hub at the proximal end of the housing and includes a needle bevel at the distal end. The sheath bevel and needle bevel may be offset from each other. A safety needle device having a retractable sheath having a graduated injection depth gauge to indicate needle penetration is also disclosed.

Abstract: Pericardial modification devices and methods can be used for the treatment of heart conditions. For example, this document describes devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure. In one example embodiment, a method for treating diastolic heart failure includes creating an opening in a patient's pericardial tissue, or removing a portion of the patient's pericardial tissue. The creation of the opening or the removing of the pericardial tissue reduces pressure exerted by the pericardial tissue on the patient's heart. The pericardial modification procedures are performed while avoiding trauma to the epicardial surface of heart as well as the phrenic nerves.

Abstract: An injection analgesia system advantageously numbs a patient's skin around an injection site. An injection window guides a caregiver's injection placement to a relatively small area while allowing standard injection procedures to be followed, such as stretching the skin and puncturing the site with a jabbing motion. The injection analgesia system has a needle shield and an analgesia, which are layered together and applied to a skin surface. A needle shield window and a analgesia window align to form the injection window. Advantageously, the needle shield may fold and/or wrap around the injection needle for sharp object protection during and after needle disposal.

Abstract: A needle assembly for pleural space insufflation is disclosed. The needle assembly has an outer shaft defining one or more pliable tissue receivers. The needle assembly also has a needle moveable within the outer shaft from a retracted position to an engaged position that does not extend past a distal end of the outer shaft. A method of pleural space insufflation is also disclosed. A parietal pleura is contacted with a distal end of an outer shaft that defines one or more pliable tissue receivers. The distal end of the outer shaft is pushed against the parietal pleura so that a portion of the parietal pleura enters the one or more pliable tissue receivers. A needle is advanced within the outer shaft so that the needle pierces the parietal pleura.

Abstract: A needle guide formed of a base plate and a platform is provided. The base plate includes an upper surface, a lower surface, a front end, a rear end, a first side, a second side, an outer edge and an inner edge. The inner edge forms an opening in between. The platform is pivotally secured to the base plate and disposed over the opening. A locking mechanism is operable to lock the platform at different angles relative to the base plate.

Abstract: A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision.

Abstract: A venipuncture assist device includes a main body having a first surface configured to confront a target venipuncture site. The device further includes a vein capture channel disposed within the first surface configured to urge a portion of a patient's tissue and subcutaneous vein therein when the vein capture channel is evacuated by vacuum, wherein the urging creates a bend in the vein for piercing by a venipuncture needle. The device further includes one or more needle channels extending from a front main body surface configured to receive and guide the needle into the bend in the vein.

Abstract: An autoinjection device includes a main body in the front end of which is slideably mounted a drawer or front body portion. The drawer can be opened to remove or insert a syringe. Closing the drawer while pressing a multifunction button primes the drive mechanism by latching it against trigger latch. Pressing the button gain while urging the front end causes the drawer to release the trigger latch. After the injection the drawer shrouds the used needle and can be released only by pressing the button.

Abstract: A device and system for closure of an opening formed in a body vessel includes a bioabsorbable grasping member and locking member. The grasping member includes grasping lingers that are radially collapsible to the closed positions by movement of the locking member over the fingers. A distal portion of the fingers is configured to grasp an outer wall portion of the body vessel surrounding the opening when the fingers are in the open position. Movement of the locking member can cause the fingers to at least substantially close the vessel opening. Structural features on the fingers and/or locking member can inhibit proximal or distal movement of the locking member when in a locking position. A detachable arm can be coupled to the grasping member to facilitate placement of the grasping member. A sheath can fit over the detachable arm and be configured to move the locking member over the fingers.

Abstract: Described is a guiding assembly for an injection device comprising a mount adapted to receive an injection device, a first gripping member rotatably coupled to the mount, a first lateral stop member coupled to the first gripping member, and a spring biasing the first gripping member in a first angular position.

Abstract: A method for ablating tissue in or around the heart to create an enhanced lesion is provided. The distal end of a catheter including a needle electrode at its distal end is introduced into the heart. The distal end of the needle electrode is introduced into the tissue. An electrically-conductive fluid is infused through the needle electrode and into the tissue. The tissue is ablated after and/or during introduction of the fluid into the tissue. The fluid conducts ablation energy within the tissue to create a larger lesion than would be created without the introduction of the fluid.

Abstract: A feeding tube placement device comprising a shaft and a functional tip which can be removably attached to a feeding tube, and which is used by insertion into a small animal's mouth then through the wall of the esophagus where a feeding tube is attached and then drawn back into the esophagus and positioned for use in feeding.

Abstract: A skin gripping means for use with an injector (200) is disclosed. In one embodiment the skin gripping means is a needle guard (100). An exterior surface (7) of the skin gripping means (100) is provided with a plurality of fingers (6) adapted to engage a subject's skin (9) when in use. A method of performing a subcutaneous injection is also disclosed with includes the steps of bringing a skin gripping means (100) of an injector (200) into contact with the skin (9) of a subject, moving the skin gripping means (100) substantially parallel to the skin (9) to thereby form a fold (10) in the skin, moving a needle (11) of the injector (200) into the fold (10) to a suitable position for a subcutaneous injection and injecting a substance through the needle (11).

Abstract: A device and method secure a blood vessel for cannulation. The device includes two parallel skids. The device is placed on the skin of a patient with a skid on each side of a blood vessel to be phlebotomized. When the skids are pressed on the skin, fluid in the tissue is displaced to the space between the skids. The blood vessel becomes secured and unable to move or roll. With the skids still pressed on the skin, the cannula can be inserted into the blood vessel. The width and spacing of the skids are adjusted to maximize the securing effect on the blood vessel.

Abstract: An artery stabilizer device is provided for stabilizing an artery while a technician inserts a needle into the stabilized artery. Two stabilizer fingers are provided to hold an artery in place while a needle is passed between two extensions and further inserted into the artery beyond the stabilizer fingers; the device can be removed from the worksite while the tip of the needle remains lodged within the artery. A platform is disposed above the stabilizer fingers and extensions create ample distance between the stabilizer fingers and the platform for simplified palpation and improved visibility and safety. Each embodiment can create an augmented pulse at a targeted needle insertion site, making it easier for a technician to palpate the patient's pulse there. Arterial catheter insertions can be facilitated using this invention.

Abstract: A pen needle assembly (111) includes an outer shell (151) having a first end adapted to contact a patient's skin at an injection site. A hub (131) is movably disposed within the outer shell. A needle (121) is fixed to the movable hub and has a patient end for piercing the skin at the injection site. An inner shell (171) is disposed within the outer shell and adapted to engage the pen needle assembly with a drug delivery pen (100). A first spring (141) has a first end connected to the outer shell and a second end connected to the inner shell. A second spring (161) has a first end connected to the inner shell and a second end connected to the hub. An adhesive layer (191) is disposed on the movable hub for contacting and raising the skin at the injection site.

Abstract: Described is a guiding assembly for an injection device comprising a mount adapted to receive an injection device, a first gripping member rotatably coupled to the mount, a first lateral stop member coupled to the first gripping member, and a spring biasing the first gripping member in a first angular position.

Abstract: A system and method is provided for an injectable substance delivery pen comprising a microneedle hub assembly removably engaged with a pen device body which includes a cartridge, a plunger, and a drive mechanism. The hub assembly includes at least one microneedle for intradermal or shallow subcutaneous injection of the contents of the cartridge. The cartridge, plunger and drive mechanism components of the pen body are fabricated of non-compliant and non-compressible materials to allow effective communication of the cartridge contents via the microneedle patient interface.

Abstract: The invention pertains to an applicator (1) for inserting an implant, in particular a rod-like implant (2) containing an active substance, under the skin of a human or animal, comprising a housing (3), a cannula (6) extending from the housing (3), and a handle (15) for grasping and maneuvering the applicator (1) and the cannula (6) during insertion of an implant (2). In accordance with the invention, the handle (15) extends above at least part of the length of the cannula (6). Such a handle facilitates insertion of the cannula and/or accurate positioning of the implant.

Abstract: An intradermal injection adapter includes a body having a longitudinal axis and a central portion located distally relative to the body along the longitudinal axis. The central portion has a cannula channel therethrough extending generally parallel to the longitudinal axis. A cannula within the cannula channel has a sharpened tip for injection into a patient and a sharpened opposite proximal end for injection into a pen injector. A distal protrusion has a first skin contacting surface extending generally parallel to the longitudinal axis. The first skin contacting surface is spaced from the cannula such that a distal portion of the cannula extends generally parallel to the first skin contacting surface.

Abstract: An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.

Abstract: A device for locating and distending the external jugular vein is provided by a wish-bone shaped apparatus designed to engage the neck of a patent and apply sufficient pressure on the neck that the external jugular vein becomes distended due to pressure placed on the patient's neck. The device includes two distally placed flat portions that resiliently engage the patient's neck without causing choking or hindrance in breathing.

Abstract: A catheter device is useful in a procedure in which an injectable material or device is injected into a tissue of a patent. In one implementation, for example, the catheter device is useful in injecting a compound into a tissue of the heart, such as the myocardium. The distal tip portion of the catheter may include an extensible and retractable needle in combination with a camera, a balloon, a vacuum port, or any combination thereof.

Abstract: Systems, methods, and devices for providing subcutaneous hydration are disclosed. A system for providing subcutaneous hydration may include an infusion bag including a hydration fluid, a tubing removably connected to the infusion bag, a squeezable bulb at least partially encompassing the tubing for at least one of flushing and priming the tubing, and a deployment device including an integrated needle which is operative provide subcutaneous hydration through the needle. A deployment device for subcutaneous hydration includes a base may include a needle aperture, a spring-loaded barrel attached the base and including a needle, and a firing mechanism within the barrel for deploying the needle from the barrel and further operative to project the needle through the aperture only when a tent of skin has been raised within the aperture for injection. A method for providing subcutaneous hydration may include steps necessary to operate the systems and devices for subcutaneous hydration.

Abstract: A syringe (211) includes a syringe body (217) for receiving and administering a medicament. A needle (215) is received by the syringe body (217). A needle adjusting member (221) is movably disposed on the syringe body (217) between first and second positions. When the needle adjusting member (221) is in the first position, the needle (215) has a first length adapted to draw medicament into the syringe body (217). When the needle adjusting member (221) is in the second position, the needle (215) has a second length for injecting the medicament.

Abstract: An injector for delivering an injectate into the myocardium of the heart may be implemented as a catheter or a handheld unit. The injector includes a body, a stabilizer secured to a distal end of the body, and a needle that may be controllably advanced from the distal end of the body. The stabilizer stabilizes the distal end of the body relative to the myocardium while the heart beats. An enlarged region disposed along the needle prevents the needle from being advanced into the myocardium beyond a desired penetration depth. To make an injection, the physician brings the distal end of the body in proximity to the myocardium, actuates the stabilizer to stabilize the distal end relative to the myocardium, and advances the needle into the myocardium. Advancement of the needle is impeded by the enlarged region, thereby placing the needle tip at the desired penetration depth for the injection.

Abstract: A device (10, 110) for facilitating insertion of a needle or a cannula into a vein of a patient, the device (10, 110) comprising means (20, 120, 220) for creating a localized area of reduced pressure at a surface of the patient's skin, so as to facilitate expansion of an underlying part of the vein, and means (26, 226) for enabling insertion of a needle or cannula into the expanded part of the vein.

Abstract: A device (10) is provided for facilitating insertion of a needle or a cannula into a vein of a patient. The device comprises a fluid chamber (23) adapted to be held in operable engagement with a surface of the patient's skin by a fastener (30/34/35) that extends about a limb of the patient. The device is adapted to create a volume of reduced pressure within the fluid chamber, so as to facilitate expansion of an underlying part of the vein. The device enables insertion of a needle or cannula into the expanded part of the vein, whilst the fluid chamber remains operably engaged with the surface of a patient's skin.

Abstract: An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.

Abstract: An applicator used to apply microneedle arrays to a mammal. In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

Abstract: Devices and methods for guidewire assisted placement of catheters into blood vessels are described. Some of the devices and methods relate to automated or partially automated or assisted insertion and placement of an intravenous catheter into a vein or artery of a patient. Other of the devices are blood draw devices and methods for insertion and placement of an intravenous device into a vein or artery of a patient or to withdraw a blood sample from the patient. The devices also provide for guide wire tip inspection after use.

Abstract: To securely position a needle tip and a blade face of a needle tube inserted into the skin in a predetermined site of a living body, such as the upper layer of skin, an injection needle assembly includes a needle tube having a needle tip capable of puncturing a living body, a hub holding the needle tube, a stabilizer, and a guide portion. The stabilizer is formed in a tubular shape surrounding the circumference of the needle tube, and an end face is pressed against the skin, and thereby a raised portion of the skin is formed in a tube hole. The guide portion is arranged on the stabilizer, and is adapted to recognize a press-in distance y of the stabilizer to the skin.

Abstract: A drug delivery device for delivering a drug to a preselected treatment site, includes a rupturable film capsule enclosing a quantity of the drug to be delivered; an array of micro-needles formed with passageways therethrough carried by the device; a covering layer overlying the capsule and forming a fluid-tight seal with the perimeter of the micro-needle array such that when the device is located with the micro-needles facing the treatment site, the application of pressure to the device causes the micro-needles to penetrate the treatment site and the capsule film to rupture to deliver the drug via the passageways to the treatment site; and an open mesh layer adjacent to the array of micro-needles effective, upon rupture of the capsule film, to uniformly distribute the drug to the micro-needles and also to reduce the possibility of clogging of the passageways.

Abstract: A needle tip of a needle tube stuck in the skin is caused to be reliably positioned in the skin upper layer part and the injected drug is caused not to leak to the outside of the body. An injection needle is provided with a needle tube having a needle tip, a hub that holds the needle tube and an adjustment unit provided around the needle tube and having a needle-protruding surface through which the needle tip of the needle tube protrudes. The needle-protruding surface of the adjustment unit is formed such that the distance S from the circumferential edge to the circumferential surface of the needle tube is in the range of 0.3-1.4 mm.

Abstract: An apparatus for intraocular injection comprising a body adapted to accommodate an injection device, a displacement device coupled to a distal end of the body, and a sleeve coupled to the body and axially moveable relative to the body. The displacement device includes at least one rotatable member adapted to contact a superficial layer of an eye, and the sleeve engages and causes rotation of the at least one rotatable member as the sleeve moves from a first axial position to a second axial position. Rotation of the at least one rotatable member displaces the superficial layer relative to an underlying layer of the eye.

Abstract: An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. The device may include a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.