Abstract: A fluid check-valve for venting gas from a fluidic system comprises a retention body defining a fluid aperture having an upstream side and a downstream side, a hydrophilic porous material held by the retention body and disposed to cover the fluid aperture, and a hydrophobic porous material held by the retention body and disposed to cover the fluid aperture and adjacent the hydrophilic porous material. One face of the hydrophilic porous material is in fluid communication with the upstream side of the aperture, and one face of the hydrophobic porous material is in fluid communication with the downstream side of the aperture. The hydrophilic porous material is configured to retain liquid from the upstream side to hinder passage of gas from the downstream side to the upstream side, and the hydrophobic porous material is configured to hinder passage of liquid from the upstream side to the downstream side.

Abstract: Disclosed is an auto injector and a related method, and a related system, for administering injection of a medicament comprising a first medicament component and a second medicament component. The auto injector comprising a housing, a receiving part, an operational module and a processing unit. The processing unit being configured to operate a syringe operational part to move a carrier to mix the first medicament component and the second medicament component to obtain a mixed medicament. The movement of the carrier having a time varying acceleration profile. The time varying acceleration profile having a first maximum acceleration in a first mixing direction and a second maximum acceleration in a second mixing direction. The first maximum acceleration and/or the second maximum acceleration is larger than a predetermined acceleration threshold.

Abstract: Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.

Abstract: Vial dosing systems and methods are disclosed. A vial dosing device includes a connecting body coupleable to a vial, a cannulated plunger having a proximal end coupled to the connecting body, a dose chamber adapted to slidably receive a distal end of the cannulated plunger and to expel medicament through a distal end of the dose chamber, and a plunger tip check valve coupled to the cannulated plunger and adapted for fluid flow from the cannulated plunger through the plunger tip check valve into the dose chamber.

Abstract: Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.

Abstract: Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.

Abstract: Embodiments of a retractable syringe assembly are provided that include a single syringe barrel configuration and dual syringe barrel configuration. In one or more embodiments, the assemblies include a barrel having a dividing wall to divide the chamber to define a fluid chamber having a first cross-sectional width for retaining fluid and a needle chamber for housing a needle hub assembly. The assemblies include a projection extending radially outwardly from the plunger rod to interact with a ramped portion of the dividing wall to cause the needle cannula to retract and be housed within the needle chamber.

Abstract: An apparatus includes a medicament container, a first elastomeric member, a second elastomeric member and a stopper. The first and second elastomeric members are disposed within the medicament container. The first elastomeric member, a first portion of the medicament container and the second elastomeric member collectively define a medicament volume. The stopper is coupled to a distal end portion of the medicament container. The second elastomeric member, a second portion of the medicament container and the stopper collectively define a vent volume. A first retainer of the stopper is configured to engage a first portion of a carrier to limit movement of the medicament container when in a first position. A second retainer of the stopper is configured to engage a second portion of the carrier to limit movement of the medicament container when in a second position.

Abstract: The present invention relates to a supplementary device a supplementary device for a manually operable injection device. The supplementary device has a body defining a passage through which an injection device is slidable, and a securing unit to secure the body to the injection device in the specific position when the injection device is received through the passage.

Abstract: Methods and apparatuses for embolizing an artery in a living subject using a catheter are disclosed. The catheter has a lumen and also has a balloon located near the distal end of the catheter. The distal end of the catheter is introduced into the artery, and the balloon is inflated to form a seal that prevents blood in the artery from flowing past the balloon. A mixture that includes embolic particles and contrast agent is injected through the lumen into the portion of the artery that is distally beyond the balloon. The subject's own blood or another fluid that contains platelets is injected through the lumen into the portion of the artery that is distally beyond the balloon. Subsequently, the balloon is deflated and the distal end of the catheter is withdrawn.

Abstract: The present invention provides a plunger (20) for a dispenser, the plunger including a large diameter body portion (23) provided with ring-shaped contact surfaces (24, 25) that contact an inner wall surface of a syringe, a rear opening (26) formed in a backside of the large diameter body portion (23), and a small diameter body portion (22) provided with a front opening (28), wherein the front opening (28) is formed in a size allowing a liquid material to be directly pressed by pressurized air, and allowing at least the plunger (20) to move following a fall in water head position, which is caused with discharge and consumption of the liquid material. With those features, the liquid material can be prevented from adhering to the inner wall surface of the syringe, and the liquid material in the syringe can be prevented from flowing backwards.

Abstract: A medicated module attachable to a drug delivery device comprising a connecting body configured for attachment to the drug delivery device. A first needle held within a first needle hub of the connecting body and a second needle fixed within a second needle hub of the connecting body. A recess within the connecting body defining a reservoir. The reservoir containing at least one dose of a medicament and configured for fluid communication with the first needle. The connecting body further comprises a lockout feature that prevents the medicated module from being reconnected to the drug delivery device after the medicated module has been connected to the drug delivery device a first time.

Abstract: A dedicated device for detection of vascular shunts can include a first chamber, a second chamber, and a third chamber. The first chamber can be configured to hold liquid, the second chamber to hold gas, and the third chamber can be in communication with the first and second chambers. The third chamber can include small-scale geometric features configured to produce gas bubbles as liquid from the first chamber and gas from the second chamber simultaneously flow into the third chamber. The device can also include a device opening in communication with the third chamber such that a mixture of liquid and gas bubbles can flow out of the device opening. The device can also include a plunger configured to force the liquid and the gas simultaneously from the first and second chambers, through the third chamber to mix with each other and produce bubbles, and further through the device opening.

Abstract: Embodiments of a retractable syringe assembly are provided that include a single syringe barrel configuration and dual syringe barrel configuration. In one or more embodiments, the assemblies include a barrel having a dividing wall to divide the chamber to define a fluid chamber having a first cross-sectional width for retaining fluid and a needle chamber for housing a needle hub assembly. The assemblies include a projection extending radially outwardly from the plunger rod to interact with a ramped portion of the dividing wall to cause the needle cannula to retract and be housed within the needle chamber.

Abstract: An application device with a cylindrical basic body for storing a squeezable dental material having a piston positioned inside the basic body and axially displaceable towards the basic body. A piston rod serves to displace the piston in the squeezing direction, which piston rod partially reaches into the piston and is axially displaceable towards the latter. The piston is provided with an elastic resetting device at its front end area positioned in the direction towards the dental material. The elastic resetting device can be biased in the squeezing direction, and returns back to its relaxed position after the end of each axial movement of the piston in the squeezing direction and release of the pressure exerted on the piston rod for this purpose.

Abstract: A medication delivery device (100) comprises a container (101) for holding a medication (104) and a piston (102) which is at least partly arranged within the container (101) and which is axially displaceable with respect to the container (101). The piston (102) is at least partly arranged at a distance from an inner surface (112) of the container (101), thereby providing a channel (116) between the piston (102) and the container (101). The device (100) further comprises a seal (103), the seal (103) being arranged to limit the channel (116) proximally.

Abstract: The present invention relates to an administration instrument for medical use that can perform injection of a drug solution with stability and with great reliability. For example, at the administration, it is possible to prevent a force that presses the injection button from acting in a direction of inserting the needle that is inserted into the skin deeper, and enables the administration under a stable state where the needle does not wobble, thereby alleviating physical and mental pain of the administration patient. With a structure in which an injection button (3) is pressed at an angle that is not parallel to the needle with respect to a direction in which the needle (4) is inserted into the skin, it is possible to prevent the force of pressing the injection button from being transmitted in a direction of inserting the needle into the skin deeper than the initial insertion of the needle, thereby achieving an administration under a stable state.

Abstract: An automatic administration instrument includes a syringe and a partition wall in the syringe which partitions the syringe into different rooms for respectively holding plural kinds of drug solutions or a drug and a drug solution. A partition-wall driver displaces the partition wall and an injection needle is connected to the syringe. A body cap attached to the administration instrument body so as to cover the injection needle. The syringe, the partition wall, and the body cap are configured such that displacing the partition wall dissolves or mixes the drug solutions or the drug and the drug solution in a state that the injection needle is covered by the body cap.

Abstract: The present invention relates to an injection assistance device (1) comprising a body (2) with a needle (7), grasping means (4) and first elastic return means (9) to dampen limited movement of said grasping means (4), in at least one of the two directions, respectively distal or proximal, during an injection phase, and to maintain said body (2) in its insertion position and said needle (7) at a constant insertion length during the injection step, when the user increases, respectively releases, a distal pressure on the grasping means (4). The invention also relates to an injection set (100) comprising an injection device (3) and the said assistance device (1).

Abstract: A metered enteral feeding system for delivering fluids, the metered enteral feeding system including a vented container with contained volume for containing the fluids. The metered enteral feeding system includes a discharge port for discharging the fluid from the contained volume and at least one vent for allowing airflow into the contained volume. The metered enteral feeding system also includes a flow control valve in fluid communication with the discharge port of the vented container. The fluid control valve is adjustable to provide an increased or decreased flowrate therethrough.

Abstract: A perfusion device and method is provided in various examples. In an example, the device includes a container having a first internal chamber configured to hold the material; a port for introducing the liquid into the chamber; a vent for releasing gas and liquid from the chamber; and a flow control device for sealing the vent to allow a vacuum to be drawn on the first chamber. In an example, the container includes a syringe that defines the internal material chamber and includes an end cap and a plunger. The vent may be formed by a venting passageway in the plunger and/or the cap. In various examples, the vacuum may be created by a medical syringe coupled to the container. In some examples, the medical syringe may also be used to deliver the liquid into the container.

Abstract: A fluid syringe of the type used with fluid infusion devices is presented here. The fluid syringe generally includes a barrel, a piston, and a check valve seal. The barrel has an interior wall and a sealed main fluid chamber. The piston is slidably coupled within the barrel, and the piston has a piston seal forming an interference fluid seal against the interior wall. The check valve seal is coupled to the piston, and it is located between the piston seal and the main fluid chamber. The check valve seal forms an interference fluid seal against the interior wall when the piston is unloaded, and it disengages the interior wall to allow gas flow from the main fluid chamber toward the piston seal when the piston is loaded.

Abstract: A single use delivery device is disclosed having a manually deformable liquid container defining an inner chamber, the container having a distal end, a body, a proximal end, and an outlet on the distal end; a tip projecting from the outlet on the distal end of the container, the tip in fluid communication with the inner chamber of the container; and a primer element for removing one or more air bubbles from the chamber, said primer element being attached to and in fluid communication with the deformable container. A method of administering a fluid to or flushing a vascular access device using a single use pre-filled delivery device as described herein is also disclosed.

Abstract: A single use pre-filled delivery device is disclosed having a deformable container including a side wall having an inside surface defining a chamber for retaining fluid, a clip element, and a locking element. The deformable container further includes a closed proximal end and an open distal end including a male luer tip having a passageway therethrough providing fluid communication with the chamber. The male luer tip may be removably connectable to a female luer connection of a vascular access device. The clip element includes a distal end, proximal end, and a pivot located between the distal end and the proximal end of the clip element for collapsing the deformable container to drive fluid out of the chamber by movement of the proximal end towards the distal end. The pivot may be a hinge, which may be in the form of a living hinge. The deformable container may be attached to the clip element. The locking element may be disposed on the clip element.

Abstract: A syringe which disperses medicate across a zone in the body during apparent conventional operation. The improved syringe includes a barrel, a plunger, and an operating cylinder. In operation, the needle of the syringe is inserted into the body at the distal portion of the portion of the body which is to receive the medicate. A single arm is attached to the barrel and passes through an operating cylinder with a thumb rest on its top. As a result, in operation, the user draws the single arm up to the thumb rest, thus causing the syringe to withdraw during injection and leaving a patch of medicate during operation.

Abstract: The present disclosure relates to a self-venting cannula assembly. The self-venting cannula assembly including an outer tube that defines a throughbore, an inner tube, a vent aperture, and a filter element. The inner tube is positioned within the outer tube, which defines a vent channel therebetween. The vent aperture is formed in the outer tube to provide fluid communication between the vent channel and an external environment. The filter element is positioned over the vent aperture and prevents particles having a dimension greater than about 0.2 microns from passing therethrough.

Abstract: A method and system for sequentially dispensing a non-user settable dose of one medicament followed by a user-settable dose of a primary medicament. The system may include a dual cross-section, floating piston arranged to facilitate first delivering all or substantially all of a given medicament (e.g., a secondary medicament) through an output needle and then thereafter delivering yet another medicament (e.g., a primary medicament) through the same output needle in a single injection step. The dual cross-section, floating piston of the system also reduces or limits ullage left in the medicated module relative to the amount of the secondary medicament dispensed from the system.

Abstract: A device for applying a lock solution in a catheter or other access system comprises a syringe (302) having an expulsion arrangement (305, 311) for expelling the lock solution from the device, said expulsion arrangement including a plunger (305) arranged in a housing (304), further comprising a sterile connector (303) for connecting the syringe (302) to the catheter. The connector (303) is arranged to engage a tip (307) of the expulsion arrangement (305, 311) tightly when the syringe (302) is inserted in the connector (303). The connector (303) is arranged to prevent the tip (307) of the expulsion arrangement (305, 311) from entering the catheter. The tip (307) is frangible. A method of applying a lock solution in a catheter or other access system is also disclosed.

Abstract: A method and pump that accurately senses air in a fluid delivery line pulses or activates and deactivates the air sensor(s) multiple times during the pumping phase of the fluid delivery cycle and can generate alarms based upon a single indication or a cumulative indication of air in the line. The pump can include multiple air sensors spaced along the delivery line so that the method can use the multiple signals therefrom to distinguish real moving air bubbles from false positives and/or air bubbles adhered to the inner wall of the line.

Abstract: A vascular access device may include a body, housing, neck, and a septum with a substantially non-gaseous cross section. A method of operating a septum of a vascular access device may include providing a vascular access device in an external environment and actuating the septum without transferring a substantial amount of gas from within the device to the external environment of the device.

Abstract: An elastic shield for a conventional syringe is disclosed. In addition, two embodiments for providing a prime free syringe are disclosed. A first embodiment employs a tube which delivers liquid only from a liquid only zone within an associated syringe while a second embodiment is disclosed to discharge gas out of a proximal side of a plunger to void gas from a syringe delivery chamber.

Abstract: A wearable infusion device comprises a reservoir that holds a liquid medicament, an outlet port that delivers the liquid medicament to a patient, a pump that displaces a volume of the liquid medicament to the outlet port when actuated, and a control that actuates the pump. A lock-out disables the device when a predefined amount of medicament has been delivered to the outlet.

Abstract: A wearable infusion device comprises a reservoir that holds a liquid medicament, an outlet port that delivers the liquid medicament to a patient, a pump that delivers a volume of the liquid medicament from the reservoir to the outlet when actuated, and a tactile indicator representing the volume of the liquid medicament delivered to the outlet with each actuation of the pump.

Abstract: A wearable infusion device comprises a first control movable between a first position and a second position that when in the first position, establishes a first fluid path between a reservoir and a pump and when in the second position, establishes a second fluid path between the pump and an outlet. A second control actuates the pump only when the second fluid path has been established by the first control.

Abstract: The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.

Abstract: Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

Abstract: Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

Abstract: The present disclosure relates to a self-venting cannula assembly. The self-venting cannula assembly including an outer tube that defines a throughbore, an inner tube, a vent aperture, and a filter element. The inner tube is positioned within the outer tube, which defines a vent channel therebetween. The vent aperture is formed in the outer tube to provide fluid communication between the vent channel and an external environment. The filter element is positioned over the vent aperture and prevents particles having a dimension greater than about 0.2 microns from passing therethrough.

Abstract: Various embodiments of the present invention are directed to limiting a presence of air bubbles in a fluidic medium expelled from a reservoir. In various embodiments, a plunger head within a reservoir is shaped so as to limit a presence of air bubbles in a fluidic medium expelled from the reservoir. Also, in various embodiments, a reservoir is shaped so as to limit a presence of air bubbles in a fluidic medium expelled from the reservoir. In some embodiments, both a reservoir and a plunger head within the reservoir are shaped so as to limit a presence of air bubbles in a fluidic medium expelled from the reservoir.

Abstract: Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

Abstract: Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

Abstract: Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

Abstract: A method and pump that accurately senses air in a fluid delivery line pulses or activates and deactivates the air sensor(s) multiple times during the pumping phase of the fluid delivery cycle and can generate alarms based upon a single indication or a cumulative indication of air in the line. The pump can include multiple air sensors spaced along the delivery line so that the method can use the multiple signals therefrom to distinguish real moving air bubbles from false positives and/or air bubbles adhered to the inner wall of the line.

Abstract: A device for applying a lock solution in a catheter or other access system comprises a syringe (302) having an expulsion arrangement (305, 311) for expelling the lock solution from the device, said expulsion arrangement including a plunger (305) arranged in a housing (304), further comprising a sterile connector (303) for connecting the syringe (302) to the catheter. The connector (303) is arranged to engage a tip (307) of the expulsion arrangement (305, 311) tightly when the syringe (302) is inserted in the connector (303). The connector (303) is arranged to prevent the tip (307) of the expulsion arrangement (305, 311) from entering the catheter. The tip (307) is frangible. A method of applying a lock solution in a catheter or other access system is also disclosed.

Abstract: An apparatus for loading a bone graft material includes a preloading assembly, and a dispenser assembly. A method of dispensing bone graft material includes loading bone graft material into the preloader, compacting the material and transferring the compacted bone graft material into the cannula. The compacted bone graft material is vented to release unwanted or undesirable air, vapor or other gases from the bone graft material. The bone graft material is dispensed after the cannula is placed in a desired or selected position with respect to an intervertebral space.

Abstract: A method of removing air from a flow path of a medical fluid injection system is described. An exemplary method performed by the medical fluid injection device includes delivering a first amount of fluid to a fluid flow path, isolating fluid flow along the flow path, forming a vacuum condition upstream of the fluid isolation, re-establishing fluid communications along the flow path, and delivering a second amount of fluid to the flow path.

Abstract: An external stylette needle device for use in medical/surgical procedures to reduce the introduction of air into a patient and method of use comprising a stylette sizably fit over at least a portion of the exterior surface of a hollow core needle shaft such that the stylette can slide about the needle shaft. The needle having a proximal end including a hub and a distal end including a tip and a distal orifice, the needle further comprising a proximal orifice adjacent the hub. The stylette being further adapted to alternately and reversibly close or open the needle distal orifice and the needle proximal orifice. The device may include an electromagnetic charge to ensure that the stylette remains in contact with the external surface of the needle.

Abstract: A sealing assembly movable within an opening of a medicament container allows (1) gases to be vented from the container, (2) medication to be stored in the container, and (3) medication to be dispensed from the container. Methods of limiting exposure of the medication to oxygen to prevent degradation of the medication while in the medicament container are also disclosed.

Abstract: A combined container-syringe includes: a cartridge; a needle hub having a base portion, a cylinder portion inside which a bypass chamber is formed, and a needle attachment portion inside which an introducing hole communicated with an injection needle is formed; a front stopper; a rear stopper; and a plunger rod connected to the rear stopper, in which: a bypass groove communicated with the introducing hole, and an annular groove connected to the bypass groove are formed on an inner circumferential surface of the bypass chamber; an air-bubble introducing groove is formed on an outer circumferential surface of the front stopper, the air-bubble introducing groove extending from a rear end surface of the front stopper toward a front end; and the air-bubble introducing groove and the annular groove are communicated with each other in a state where a part of the front stopper is disposed in the cartridge.

Abstract: A syringe barrel for pre-filled syringe formulation capable of suppressing the adhesion of air bubbles, and a pre-filled syringe formulation having the adhesion of air bubbles suppressed, are provided, and a process allowing efficient production of the syringe barrel is provided. A syringe barrel for pre-filled syringe formulation having the interior surface treated by corona discharge; a pre-filled syringe formulation having a drug solution filled and sealed in the syringe barrel; and a process for producing a syringe barrel for pre-filled syringe formulation, including subjecting the interior surface of a syringe barrel to a corona discharge treatment.