Material Fed To Reservoir Through Hollow Piston Patents (Class 604/184)
  • Patent number: 11596628
    Abstract: The invention relates to extended-release formulations comprising: (i) a poorly water-soluble active pharmaceutical ingredient; and (ii) a non-aqueous liquid vehicle comprising (a) a hydrophobic lipid comprising a glyceryl ester of a C6-C24 fatty acid, or (b) a hydrophilic organic compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, and dimethylsulfoxide, or (c) a combination of (a) and (b), and (iii) an amphiphilic agent wherein the active pharmaceutical ingredient is dispersed as discrete particles having a D90 particle size of about 0.5 ?m to about 25 ?m in the formulation, and wherein the formulation is non-gelling and thixotropic with a viscosity of less than 10 poise at a shear rate of 10/s at 25° C.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: March 7, 2023
    Assignee: Abon Pharmaceuticals, LLC
    Inventors: Salah U. Ahmed, Yanming Zu, Jason LePree, Hetalben Prajapati, Tahseen A. Chowdhury
  • Patent number: 11547810
    Abstract: A drug delivery device is provided herein, the device including a reservoir for containing a medicament. The medicament includes a suspension of solids in a liquid carrier. The device also includes a needle having a distal end for injection into a patient, a proximal end in communication with the reservoir, and a lumen extending between the distal and proximal ends. A path is defined from the reservoir to the distal end of the needle through the lumen, the path having an inner diameter that decreases in a proximal to distal direction along at least a portion thereof. Advantageously, with the subject invention, a flow path may be defined which provides a more gradual transition in diameter from the reservoir to a distal tip of the needle. In this manner, changes in velocity of the suspension may be less abrupt than in the prior art, thus better maintaining solid particles in the suspension.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: January 10, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Roger Groskopf, Behzad D. Mottahed
  • Patent number: 11504465
    Abstract: Inline pumps with rear attachable syringes include a pump and a syringe with each designed so that the pump syringe system may be easily coupled and decoupled in the field. An end mount block on the pump has a slot shaped to accept a similarly shaped plunger button and plunger rod on the syringe. A user aligns the plunger button of the syringe next to the slot on the mount block of the pump, and slides the plunger button and rod into the inner cavity of the pump. Both the pump and the syringe have threaded couplers which securely couple the pump to the syringe by rotating the couplers with respect to each other.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: November 22, 2022
    Assignee: FLEX FLUIDICS, LLC
    Inventor: Michael Marshall
  • Patent number: 11364146
    Abstract: An ophthalmic device including a cannula having a cannula distal end, a lumen, and one or more orifices coupled to the lumen is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula. The internal mechanism includes a follower fixedly coupled to the sleeve and moveable between distal and proximal positions, and a release member movable between an activated position and a release position. The release member is coupled to the actuator and configured to release a force that urges the follower from the distal position to the proximal position when the release member moves from the activated position to the release position.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: June 21, 2022
    Assignee: NEW WORLD MEDICAL, INC.
    Inventors: Malik Y. Kahook, Eric Porteous, Carlos A. Mendoza
  • Patent number: 11154420
    Abstract: A device for controlled delivery of an injection material to tissue spaces of an eye that are not normally open, such as the subconjunctival space, the suprachoroidal space and the subretinal space. The device comprises an elongated body with a hollow cannula at the distal end, a slidable plunger at the proximal end, and a reservoir for the material to be injected residing between the cannula and the plunger. The plunger is mechanically coupled to a source of force such as a spring or pressurized gas reservoir such that an injection force is applied to the injection material within the device prior to delivery of the injection material into an eye. A valve that is normally closed to prevent flow of the injection material during application of the injection force is placed in the flow path between the cannula and reservoir. Due to the injection force placed on the injection material, actuation of the valve allows controlled flow from the reservoir through the cannula and into the tissue space.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: October 26, 2021
    Assignee: Oxular Limited
    Inventors: Ronald K. Yamamoto, Stanley R. Conston, Robert Steven Bley
  • Patent number: 11147709
    Abstract: An ophthalmic device including a cannula having a cannula distal end, a lumen, and one or more orifices coupled to the lumen is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula. The internal mechanism includes a follower fixedly coupled to the sleeve and moveable between distal and proximal positions, and a release member movable between an activated position and a release position. The release member is coupled to the actuator and configured to release a force that urges the follower from the distal position to the proximal position when the release member moves from the activated position to the release position.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: October 19, 2021
    Assignee: NEW WORLD MEDICAL, INC.
    Inventors: Malik Y. Kahook, Eric Porteous, Carlos A. Mendoza
  • Patent number: 11096822
    Abstract: Injection device comprising an elongated body (1) with a hollow needle (8) at a distal end; a reservoir for an injection material to be delivered through the needle; a plunger (3) with a first force element (5) configured to provide an injection force to said injection material, and a distal element (10) attached to the distal end of the device thereby sealing a needle lumen, wherein the distal element comprises a tissue interface and a distal seal (11), and wherein the distal seal is penetrable by a distal tip of the needle by the application of pressure on a tissue surface with the distal end of the device, wherein the penetrated distal element becomes slidable on the needle to allow advancement of the needle into tissue, wherein the penetrated distal seal opens a path for flow or delivery of the injection material from the distal end of the needle.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: August 24, 2021
    Assignee: Oxular Limited
    Inventors: Ronald K. Yamamoto, Stanley R. Conston
  • Patent number: 10772620
    Abstract: An adjustable motion limiter for a minimally invasive surgical device is disclosed. The adjustable motion limiter includes a cam surface and a positioning interface. Another adjustable motion limiter for a minimally invasive surgical device is disclosed. The adjustable motion limiter has a positioning interface comprising a grooved protrusion. The adjustable motion limiter also has a cam surface comprising an arcuate surface and facing a direction which is substantially perpendicular to a direction the positioning interface faces. The adjustable motion limiter further has an adjustment key and one or more locking teeth. A minimally invasive surgical device having an adjustable motion limiter is also disclosed.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: September 15, 2020
    Assignee: LSI Solutions, Inc.
    Inventors: Jude S. Sauer, John F. Hammond
  • Patent number: 10695470
    Abstract: Inline pumps with rear attachable syringes include a pump and a syringe with each designed so that the pump syringe system may be easily coupled and decoupled in the field. An end mount block on the pump has a slot shaped to accept a similarly shaped plunger button and plunger rod on the syringe. A user aligns the plunger button of the syringe next to the slot on the mount block of the pump, and slides the plunger button and rod into the inner cavity of the pump. Both the pump and the syringe have threaded couplers which securely couple the pump to the syringe by rotating the couplers with respect to each other.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: June 30, 2020
    Assignee: FLEX FLUIDICS, LLC
    Inventor: Michael Marshall
  • Patent number: 10413672
    Abstract: A dispensing device (1) for dispensing a fluid, preferably an injection syringe. The device comprises a main body (2) which has a longitudinal axis (A) and has a receiving space (3) for receiving the fluid, and a connection channel (4) communicates with the receiving space. The connection channel opens on a valve face (5) of the main body. The device comprises a movable flow control element (6) arranged on the main body. The flow control element has one or more flow channels (7) which open on a valve face (8) of the flow control element. The connection channel of the main body and the flow channels of the flow control element are fluidically connected to each other by relative movement of main body and flow control element. A sealing element (10) is arranged between the valve face of the main body and the valve face of the flow control element.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: September 17, 2019
    Assignee: Weibel CDS AG
    Inventors: Ludwig Daniel Weibel, Christoph Egloff
  • Patent number: 10238802
    Abstract: A syringe includes a first syringe barrel and a second syringe barrel. Each barrel includes a delivery end to which an end piece with a channel is secured, a piston which is arranged movable in the syringe barrel and can be moved towards the delivery end in order to deliver a fluid located between the delivery end and the piston via the channel. The two syringe barrels are mechanically connected to each other such that the distance between them cannot be changed. At least one of the two end pieces can be secured to the allocated delivery end in different positions for adjustment of the distance between the two channels.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: March 26, 2019
    Assignee: Henke-Sass, Wolf GmbH
    Inventors: Melanie Eisele, Frank Altermann
  • Patent number: 10092701
    Abstract: A medical cartridge containing multiple doses of a medical drug is disclosed. An outlet end is arranged to be connected to an injection needle for delivering the medical drug. The medical cartridge comprises a one way valve arranged in an interior part of the medical cartridge at a position near the outlet end. The one way valve allows a fluid flow from the interior of the medical cartridge towards the outlet end, but prevents a fluid flow from the outlet end towards the interior of the medical cartridge. Thereby the risk of contamination of the medical drug remaining in the cartridge is minimized.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: October 9, 2018
    Assignee: MEDICOM INNOVATION PARTNER A/S
    Inventors: Esben W. Johansen, Niels Kure, Henrik Leisner
  • Patent number: 9849221
    Abstract: Inline pumps with rear attachable syringes are disclosed. The pump and the syringe are each designed so that the pump syringe system may be easily coupled and decoupled in the field. An end mount block on the pump has a slot shaped to accept a similarly shaped plunger button and plunger rod on the syringe. A user aligns the plunger button of the syringe next to the slot on the mount block of the pump, and slides the plunger button and rod into the inner cavity of the pump. Both the pump and the syringe have threaded couplers which securely couple the pump to the syringe by rotating the couplers with respect to each other.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: December 26, 2017
    Assignee: FLEX FLUIDICS, LLC
    Inventor: Michael Marshall
  • Patent number: 9272803
    Abstract: A vacuum cementing system has at least one cement powder cartridge and a container-opening system. The container-opening system has at least one container for at least one liquid and/or at least one powder, an opening device, and an outlet opening for applying a negative pressure. When a negative pressure is being applied, the opening device is mobile relative to at least a part of the at least one container. The vacuum cementing system has a means for connecting the cement powder cartridge to the at least one container and utilizes necessary vacuum for automatically opening the at least one container.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: March 1, 2016
    Assignee: Heraeus Medical GmbH
    Inventors: Sebastian Vogt, Hubert Buechner, Tim Schnieber
  • Patent number: 8992505
    Abstract: Apparatus and methods for providing a field environment filled proximal chamber of a multi-chamber syringe and for filling a prime-free syringe are disclosed. In addition, methods for resetting valves of a multi-chamber syringe without special tools or insertion of foreign objects into the syringe are disclosed. A valve for interfacing with syringes telescopically inserted into a larger syringe and which are generally used as proximal chambers in multi-chamber syringes used in mixing and serial delivery applications is disclosed. Four embodiments of novel resettable valves are disclosed. Also, a syringe assembly for delivering a saline-dose-saline medication sequence is disclosed.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: March 31, 2015
    Assignee: Thorne Consulting & Intellectual Property, LLC
    Inventors: Gale H. Thorne, Jr., Gale H. Thorne
  • Patent number: 8696625
    Abstract: The present invention relates to an injection assistance device (1) comprising a body (2) with a needle (7), grasping means (4) and first elastic return means (9) to dampen limited movement of said grasping means (4), in at least one of the two directions, respectively distal or proximal, during an injection phase, and to maintain said body (2) in its insertion position and said needle (7) at a constant insertion length during the injection step, when the user increases, respectively releases, a distal pressure on the grasping means (4). The invention also relates to an injection set (100) comprising an injection device (3) and the said assistance device (1).
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: April 15, 2014
    Assignee: Becton Dickinson France
    Inventors: Franck Carrel, Frederic Perot, Laurent Barrelle, Eric Olive, Jean-Pierre Grimard, Samuel Gagnieux
  • Patent number: 8696639
    Abstract: A variably flexible insertion device includes a hollow body having a proximal end with an entrance for receiving an instrument and a distal end with a tip for protrusion of the instrument. A device transitions the hollow body between a relatively flexible condition and a relatively stiff condition. Tendons within the hollow body maintain the hollow body in the relatively flexible and relatively stiff conditions. A method for variably flexing an insertion device for receiving an instrument, includes providing a hollow body having inner and outer sleeves defining a space therebetween in which tendons are disposed. Suction is applied to create a vacuum in the space for frictionally locking the tendons in place between the sleeves in a relatively stiff condition of the hollow body. The vacuum is relieved to release the tendons in a relatively flexible condition of the hollow body.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: April 15, 2014
    Assignee: Syntheon, LLC
    Inventors: Kevin W. Smith, Derek Dee Deville, Korey Kline, Matthew A. Palmer
  • Patent number: 8480617
    Abstract: The invention relates to an injection device for the needle-free injection of a medium. Said injection device comprises an injector device and an ampoule unit, said ampoule unit comprising a base (4) holding the medium to be injected. Said base comprises a jacket (5) which exerts pressure on the base, and jacket completely enveloping the base in the longitudinal axial direction.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: July 9, 2013
    Assignee: Painless Tech GmbH
    Inventors: Benedikt Lenzner, Stephan Theuer, Bernd Störmer-Talleur, Dirk Schulz
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler
  • Patent number: 8137307
    Abstract: A syringe device includes a syringe barrel and piston having a fluid passageway extending from a vial port. Another syringe device includes a syringe barrel, a piston sleeve and an insert. A channel extends along a side of the insert. A valve controls fluid communication between the channel and the syringe barrel. Another syringe device has a syringe barrel, a piston sleeve and an insert. A valve controls fluid communication between a compartment within the insert and the syringe barrel. A method of preparing a medication includes providing a component within a syringe barrel and another component within a compartment of a piston insert. A seal is over-molded onto a tip of the insert and an end of a piston sleeve. The sleeve is rotated relative to the insert to establish fluid communication between the compartment and the barrel chamber.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: March 20, 2012
    Assignee: Hyprotek, Inc.
    Inventors: Patrick O. Tennican, L. Myles Phipps
  • Patent number: 8088109
    Abstract: The system and method creates immediate supplemental blood flow into an organ by punching a cannula into the organ to remove a core of the organ. The process of punching creates essentially no heat and therefore does not cauterize the wound. In the case of the heart this results in immediate supplemental blood flow into the heart muscle. Animal tests have shown this immediate blood flow is sufficient to sustain the heart even when a major coronary artery is completely blocked. The procedure may be performed in an open surgical field procedure by punching cores from the outside of the heart in or it may be a percutaneous catheter procedure punching cores from the inside-out of an organ.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: January 3, 2012
    Assignee: Surgical Pioneering, LLC
    Inventors: Ernest Feiler, Warren Roh, Eckehart Zimmermann
  • Patent number: 7892210
    Abstract: An improved apparatus, method and system are provided for medical liquid administration, including in particular liquid medication and/or flush solution infusions. The inventive apparatus includes a barrel, a plunger slidably disposed within the barrel and extending from a distal end thereof, and at least one medical liquid delivery line having a proximal end fixedly positioned relative to the barrel, wherein the medical delivery line is fluidly interconnectable proximal to the plunger and extends along at least a portion of the barrel and in a direction distally away from the distal end thereof. To accommodate the administration of both a liquid medication and flush solution, two coincidentally-positioned medical liquid delivery lines may be included, each of which may extend through the plunger to the valve. The valve may be positionable to accommodate the selective administration of a desired medical liquid through an interconnected catheter interconnection line.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: February 22, 2011
    Assignee: Baxa Corporation
    Inventors: Joseph Ranalletta, Rob Brereton, Laura Zoerner, Brian Baldwin, Randall Wallace Smith, Garrett L. Barker
  • Patent number: 7762993
    Abstract: A catheter syringe conveyor with a needle guard housing is adapted to facilitate the insertion of a catheter into a targeted blood vessel. A catheter syringe is slidably situated within a hand-held housing structure; a syringe holder that is slidably connected to the housing allows a technician to maneuver the catheter syringe up and down within the housing. At least one stabilizer finger is attached to the bottom of the housing. After a blood vessel is penetrated by the needle of the catheter syringe, the technician maneuvers a catheter pusher to lower the catheter off of the needle and into the blood vessel. After the catheter is inserted, the technician is able to slide the catheter syringe back up within the housing to move the needle within the protective walls of the housing for safety, and a syringe lock holds it there securely for safekeeping.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: July 27, 2010
    Inventor: James Gerard Perez
  • Patent number: 7731065
    Abstract: A container or vial (1) for a fluid, the container (1) comprising a casing defining an interior for storage of the fluid and a closure member (2). The closure member (2) comprises a body and at least one resilient projection (7) to seal in a storage condition an outlet of the casing, wherein upon an increase in the pressure of the interior of the container (1) the at least one resilient projection (7) is deflected to accommodate outflow of fluid through the outlet. The pressure in the interior of the container (1) may be increased by displacing the closure member (2) into the container (1) or by displacing some other element such as a bung (61, 82) into the container (1). The container (1) and closure member (2) may be used in a dispenser (90) and the closure element may be used in a valve (110).
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: June 8, 2010
    Assignee: Consort Medical PLC
    Inventors: Simon James Ingram, Daljit Singh Ohbi, Richard Iain Harrison
  • Patent number: 7678080
    Abstract: An intravenous catheter introducing device includes a needle hub slidably inserted into a barrel and holding a needle cannula, a biasing member disposed to bias the needle hub to a rear position so as to retract the needle cannula in the barrel, and an easy release unit including an engaging wall segment which is attached to an outer surface of the barrel, two flexible squeezed wall segments which extend from the engaging wall segment and which is squeezable so as to move two latch members to steer clear of a retained end of the needle hub through an access hole in the barrel, thereby permitting the biasing member to bias the needle hub towards the rear position.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: March 16, 2010
    Inventors: Ming-Jeng Shue, Deborah Huang, Phillip Shue
  • Publication number: 20080265512
    Abstract: A hand assisted laparoscopic seal apparatus. The seal apparatus includes a seal body and a housing supporting the seal body. The seal body includes a core composed of a fast recovery foam and a flexible membrane covering the core.
    Type: Application
    Filed: April 27, 2007
    Publication date: October 30, 2008
    Inventors: Andrew T. Beckman, David E. Havens, Kristin Muckley, Matthew C. Everhart
  • Publication number: 20030114798
    Abstract: The present invention relates to a medicament delivery device used for self-administration of a medicament regimen by a patient. In such medicament delivery devices the administration of the medicament is from a replaceable medicament cartridge located within a housing forming a part of the medicament delivery device. Removal of the cartridge for those with infirmities who are not able to grip the cadge sufficiently firmly to place or remove the cartridge is improved by the present invention.
    Type: Application
    Filed: December 13, 2002
    Publication date: June 19, 2003
    Applicant: DCA DESIGN INTERNATIONAL LIMITED
    Inventors: Christopher Nigel Langley, Robert Frederick Veasey
  • Patent number: 6558356
    Abstract: The invention provides a medical device having first and second elongate tubular members. Each member comprises a manometer at a distal end and a lumen communicating with a port at the distal end. An expandable occlusive member is optionally mounted on either or both tubular members proximal to the distal port. A proximal end of each tubular member is adapted for attachment to an oxygenator and/or a pump for aspirating blood from an artery or a symptomatic carotid artery through the first tubular member and perfusing the blood into the contralateral carotid artery through the second tubular member, thereby providing a means of augmenting the collateral vasculature and maintaining perfusion distal to the offending lesion. The flow rate of blood can be controlled by inflating or deflating the balloon occluder. The device may employ a neuroprotective agent, hypothermic perfusion, and an atherectomy device or an extracorporeal pumping mechanism to remove a vascular occlusion and reestablish cerebral perfusion.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: May 6, 2003
    Assignee: CoAxia, Inc.
    Inventor: Denise Barbut
  • Patent number: 6428555
    Abstract: An anastomosis punch device, and method of using same, for creating a circular hole in the aortic wall, where the device also segregates the hole from the blood flow path such that no blood is lost through the hole during attachment of the vein graft. The invention is a hand-held punch having an elongated housing to be gripped by the surgeon, the housing retaining in a coaxially aligned manner a distally extended punch head, a cutting sleeve having a distal cutting rim which cuts a circular plug in cooperation with the punch head, an umbrella-like flexible dam formed of an elastic material and adjoined to the cutting sleeve in a manner which allows it to be deployed radially outward with the enlarged open rim facing the proximal direction, and a deployment ram movable axially relative to the dam to spread open the dam.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: August 6, 2002
    Inventor: J. Kenneth Koster, Jr.
  • Patent number: 6086561
    Abstract: An apparatus for delivering fluids at a precisely controlled rate which includes a fluid dispensing component having a fluid reservoir for containing the fluids to be delivered and a reservoir fill component which can be removably interconnected with the fluid dispensing component. The reservoir fill assembly is uniquely designed to accept a vial component of conventional construction which is factory filled with the medicinal fluid to be delivered to the patient. The dispenser component embodies a highly novel fluid flow indicator that provides a readily discernible visual indication of fluid flow status through the device.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: July 11, 2000
    Assignee: Science Incorporated
    Inventors: Marshall S. Kriesel, Jmaes M. Garrison, Steven Arnold, Farhad Kazemzadeh
  • Patent number: 5879336
    Abstract: The invention relates to a portable and non-implantable device to enable a patient to self-administer, on demand, successive doses of a liquid while ensuring that the period of time between two successive administrations cannot be less than a reference value. The device has a liquid reservoir formed in a piston which can be pushed in a chamber to expel the contents of the chamber via an injection outlet and which is returned in the opposite direction by a return. The liquid reservoir communicates with the inside of the chamber via a passage formed through the piston and is provided with a flow rate limiter so that the time required to fill the chamber corresponds to a reference value. The invention is suitable for medical applications.
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: March 9, 1999
    Assignee: Vygon
    Inventor: Thierry Brinon
  • Patent number: 5749968
    Abstract: An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 12, 1998
    Assignee: Focal, Inc.
    Inventors: David A. Melanson, Marc Alan Levine, John C. Spiridigliozzi, Thomas S. Bromander, Dean M. Pichon, George Selecman, David J. Nedder
  • Patent number: 5529189
    Abstract: A disposable single-use kit for administering a precise dose of radioactive tracer to a subject with an accuracy of at least 99.9% by weight. The kit comprises a syringe, pre-filled with a known quantity of a radioactive tracer as injectate. The back of a small-bore needle is affixed to the syringe front. The front of a removable plastic needle cover incorporates airtight means for creating and maintaining an airlock in the needle front, thereby to prevent any contact between the tracer and the cover and so preclude any loss of tracer upon removal of the cover from the needle. A valve normally seals the syringe back, the valve including actuatable means for enabling a fluid flow into the syringe back, both for pre-filling of the syringe with injectate and for flushing of the injectate from the syringe into the subject.
    Type: Grant
    Filed: August 2, 1995
    Date of Patent: June 25, 1996
    Assignee: Daxor Corporation
    Inventor: Joseph Feldschuh
  • Patent number: 5324266
    Abstract: A blood sampling system incorporates a fluid storage mechanism which can be disposed along the longitudinal axis of a fluid line extending from an injection site to a fluid supply. Both the main body portion of the fluid storage mechanism and a fluid draw element of the fluid storage mechanism are axially aligned with the longitudinal axis of the fluid line. The fluid storage mechanism also incorporates a vortex inducer element at the distal end of the fluid draw element to induce a swirl of fluid to cleanse the fluid storage mechanism once a sample drawn into the fluid storage mechanism has been returned to the patient. An alternative embodiment of the fluid storage mechanism includes a volume control device.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: June 28, 1994
    Assignee: Abbott Laboratories
    Inventors: William M. Ambrisco, Lauretta Iwamasa, Anthony J. Pantages
  • Patent number: 5188610
    Abstract: A fluid dispensing apparatus is provided which comprises a flexible, collapsible fluid container in fluid communication with an adjustable volume multi-dose dispensing means.
    Type: Grant
    Filed: October 18, 1991
    Date of Patent: February 23, 1993
    Assignee: Vetrisystems, Inc.
    Inventor: John R. Rains
  • Patent number: 5139488
    Abstract: The drenching gun of the present invention comprises a cylinder having an outlet opening in one end. A plunger is mounted within the cylinder and is adapted to reciprocate therein. A nozzle is attached to the outlet end of the cylinder and includes a one-way valve which is fitted within a tube in the outlet end of the chamber. The valve is integral with the nozzle. All of the forces between the cylinder and the nozzle are borne by metal parts, and a pair of pins are provided on the nozzle for cooperating with axial slots in the cylinder to hold the nozzle against rotational movement with respect to the cylinder.
    Type: Grant
    Filed: August 6, 1990
    Date of Patent: August 18, 1992
    Assignee: Syrvet, Inc.
    Inventor: Enrique E. Klein
  • Patent number: 5037399
    Abstract: Apparatus for administering liquid medication to an animal is provided and includes an elongated administering rod having a first one way valve adjacent to the tip thereof and which rod is connected to a hollow housing in which there is located a barrel syringe so that measuring indicia thereon is visible, a hollow piston mounted for reciprocal movement in the barrel syringe, a closure member for holding the barrel syringe in place and through which a hollow piston rod having the piston attached thereto reciprocates. Apparatus is provided for reciprocating the piston rod and piston. A fitting is attached to the piston rod and is connected by a flexible tube to a supply of liquid medication and a second one way valve is mounted in the fitting. When the liquid medication is being administered, the first one way valve is open and the second one way valve is closed. When the liquid medication is being aspirated into the barrel syringe, the first one way valve is closed and the second one way valve is open.
    Type: Grant
    Filed: July 7, 1989
    Date of Patent: August 6, 1991
    Inventors: Elmer L. Reichert, David P. Sievers
  • Patent number: 5015229
    Abstract: A device for dispensing liquids, in particular drugs, comprises a reservoir (11) provided with a neck (30) of reduced cross-section being engaged by a stopper element (16). The reservoir is completely covered by a cap (25) which has at one end a movable push button (28) which abuts against the bottom portion of the reservoir (10). In order to transfer the device from its storage position to its activated position, the operator must press on the push button (28) in such a way that the stopper element (16) penetrates into the interior of the reservoir beyond the neck of reduced crosssection (30). This device can be used as an injection syringe, a spray dispenser, or an applicator for the skin or eyes.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: May 14, 1991
    Assignee: Medicorp Holding S.A.
    Inventors: Gabriel Meyer, Ernst Howald
  • Patent number: 4957637
    Abstract: A device for separating and isolating heavier components from lighter components of blood mixtures after centrifugal separation, comprising a barrel for holding the blood mixture having slidably positioned therein an inner container for containing the lighter components, a one-way valve responsive to movement of the container within the barrel (a) for controlling the flow of the lighter components into the container, (b) for preventing the lighter components from re-entering the barrel from the container, and (c) for creating a vacuum to assist in drawing the blood mixture to be separated into the barrel, and a filter for filtering the lighter components during their entry into the inner container. The inner container includes an opening for access to the separated and isolated lighter components.
    Type: Grant
    Filed: May 23, 1988
    Date of Patent: September 18, 1990
    Assignee: Sherwood Medical Company
    Inventor: William D. Cornell
  • Patent number: 4772271
    Abstract: The present invention relates to a prefilled syringe comprising a reservoir containing a single dose of medicine to be injected.The principle elements of this syringe are the reservoir (10), a blocking element (12), a capsule (13) integral with this element, a needle (14), a needle-protector (15) and a cap (16). The cap (16), in place on the reservoir, makes it possible for the operator, by pressing on this cap to make the blocking element penetrate towards the interior of the reservoir a sufficient distance to cause the precise bubble removal of the syringe. To this end, the cap is connected to the capsule (13) by a base (36) comprising a zone of reduced resistance.
    Type: Grant
    Filed: April 7, 1987
    Date of Patent: September 20, 1988
    Assignee: Medicorp Holding S.A.
    Inventors: Gabriel Meyer, Ernst Howald
  • Patent number: 4758218
    Abstract: A percutaneous syringe assembly for use in the introduction of a guidewire into a blood vessel for the purpose of guiding a catheter into place. The syringe has a plunger with a central guide tube for the wire and a needle lumen for introduction of the wire into a blood vessel. A protective flexible container for a guidewire is attachable to the syringe plunger in a closed circuit with selective ends to be aligned with the central guide tube of the plunger to permit a J-end or a straight end of a wire to be introduced into a selected blood vessel.
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: July 19, 1988
    Assignee: DLP Inc.
    Inventors: Patrick J. Kiefer, James H. De Vries, Kenneth R. Jonkman
  • Patent number: 4747834
    Abstract: A reusable syringe assembly (10) in combination with a disposable syringe assembly 11 is described. A plunger 11b of the disposable syringe assembly moves with a liquid (100) as a chamber (14) in the reusable syringe assembly is refilled, thereby eliminating a conventional vertical bottle connected to the reusable syringe assembly.
    Type: Grant
    Filed: September 28, 1987
    Date of Patent: May 31, 1988
    Assignee: Ideal Instruments, Inc.
    Inventor: Gordon E. Prindle
  • Patent number: 4715853
    Abstract: A back fill syringe assembly (10) which is supplied by a fluid from a bottle (12) through a tube (11) is described. The syringe assembly preferably automatically refills upon injection of an animal.
    Type: Grant
    Filed: September 19, 1986
    Date of Patent: December 29, 1987
    Assignee: Ideal Instruments, Inc.
    Inventor: Gordon E. Prindle
  • Patent number: 4700872
    Abstract: A pump for dispensing liquid via a syringe has a chamber in which a hollow cylinder is mounted. The cylinder is connected to the chamber via a first normally closed check valve. A hollow plunger reciprocates in the cylinder is connected thereto via a second normally closed check valve. A charge of liquid is placed in the hollow plunger. On the out-stroke of the piston, the liquid in the piston is sucked through the second normally closed check valve into the cylinder and on the in-stroke of the plunger the liquid is forced through the first normally closed check valve into the chamber wherein it is maintained under pressure created by the pumping action of the plunger. An outlet tube leads from the lower part of the chamber to a syringe and an normally closed pinch valve in the syringe is manually operable to permit liquid under pressure to be squirted from the syringe.
    Type: Grant
    Filed: August 19, 1986
    Date of Patent: October 20, 1987
    Inventors: Paul H. Keyes, Marvin J. Taves
  • Patent number: 4676781
    Abstract: An injector to deliver a predetermined quantity of liquid into an animal, said injector having a hollow body with a handle, an interacting piston and cylinder mounted within the body and cooperating to define a variable volume working space, an injector needle communicating with said space, a passage also communicating with said space to enable the delivery of liquid thereto, a shroud to selectively cover said needle, and wherein movement of said shroud beyond a predetermined position exposing said needle enables relative movement between the piston and cylinder to eject liquid through said needle.
    Type: Grant
    Filed: November 18, 1985
    Date of Patent: June 30, 1987
    Assignee: N.J. Phillips Pty. Limited
    Inventors: Ian R. Phillips, Mervyn F. Reynolds, Robert H. Lodge
  • Patent number: 4657534
    Abstract: A package for materials that are to be mixed just prior to use comprises a squeezable container into which is inserted a barrel containing a plunger. One substance to be mixed is placed within the container. The second substance is placed within a compartment formed within the barrel between a pair of pistons having flexible sealing rings. Telescoping of the plunger rod into the barrel causes the upper piston to advance into the compartment. The advancing upper piston exerts hydraulic pressure causing the lower sealing piston to detach from the barrel allowing internal mixing of the substances into a mixed fluid. By squeezing the container side wall, mixed fluid may be dispensed from a forward end of the plunger rod communicating with the container interior through a series of passageways.
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: April 14, 1987
    Assignee: Alcon Laboratories, Inc.
    Inventors: Robert E. Beck, Frank E. Brown, Michael J. Jobe
  • Patent number: 4655749
    Abstract: An angioplasty pressure controller having a housing with a slidable pressure cylinder in it. A drive screw is connected to a piston in the cylinder and arranged for fine adjustment by turning the drive screw. An engagement slide to provide a rapid means to create pressure or vacuum. A connecting rod is attached at one end to the cylinder and at the other end to the plunger of a syringe. A pressure gauge is connected to the inside chamber of the cylinder.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: April 7, 1987
    Inventor: Eugene A. Fischione
  • Patent number: 4643200
    Abstract: To replace the customary short flexible tube with attached needle at one end and larger tube connector at its other end, a packaged sterile blood donor assembly is provided. The assembly includes a rigid body having a bore and being equipped at its forward end with a needle and at its rear end with a tube connector having a safety reversible cap. An exterior sleeve on the rigid body is lockable in two positions thereon with the needle in an exposed use position and with the needle retracted and locked in a safety non-use position rearwardly of a safety shield and elastic membrane on the forward end of the exterior sleeve. A discardable needle shield is also provided on the assembly.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: February 17, 1987
    Inventor: Baldwin P. Jennings, Jr.
  • Patent number: 4583970
    Abstract: A milk suction device consisting of a funnel and a piston pump connected thereto which can be operated easily as a hand-operated pump or as a motor driven pump. A hollow piston rod is constructed as an outwardly guided aeration duct and has a return valve as its opening located in the suction space of a cylinder of the pump, which return valve is closed during the suction stroke of the piston pump and is constructed as an aeration valve. A ventilation valve is arranged in a front face of the pump cylinder opposite the piston rod and in order to connect a motor driven pump, it is only necessary to slide its tube onto the free end of the piston rod.
    Type: Grant
    Filed: May 23, 1985
    Date of Patent: April 22, 1986
    Assignee: Kirchner & Wilhelm
    Inventor: Hansjorg Kirchner
  • Patent number: 4530695
    Abstract: An injector to inject liquid into an animal, said injector being of generally cylindrical configuration and having a pre-loadable piston and cylinder which when operated eject liquid through a needle of the injector, said injector having a trigger movably mounted at one end, which trigger selectively permits relative movement of the piston and cylinder to eject liquid from within the injector.
    Type: Grant
    Filed: December 19, 1983
    Date of Patent: July 23, 1985
    Assignee: N.J. Phillips Pty. Limited
    Inventors: Ian R. Phillips, Mervyn F. Reynolds, Robert H. Lodge