Abstract: A cannula for transferring a substance to and/or from a patient includes a tubular support sleeve and a transfer tube. The support sleeve includes a rigid tubular member defining a lumen extending from a proximal end to a distal end of the tubular member. The transfer tube is positioned in the lumen and extends beyond each of the proximal end and the distal end of the tubular member. The tubular member includes a rigid, MRI-compatible material.

Abstract: The scope of the invention encompasses novel, multifunctional tools for maintaining the neovagina. The tools comprise novel dilator shapes that conform the anatomical pathway of the neovagina. The tools may further include a douching function for the effective and thorough washing of the neovagina, which is not achieved with standard douching devices. The tools may also comprise a measurement function for medical evaluation of the neovagina and to aid in proper dilation. Also presented herein are novel devices for delivery of agents to the natal vagina, including insemination devices.

Abstract: The present application discloses an ear-cover structure and an ear irrigation device. The ear-cover structure includes a cover configured with a containing space with an opening configured at a side of the containing space, a liquid collecting portion extending outwards from the bottom of the cover, and an injection port configured on the cover and communicating with the containing space. The medium collected in the containing space flows through the liquid collecting portion and is discharged from a leakage port to the external environment.

Abstract: Various systems, method, and compositions for treating a tooth are disclosed herein. For example, an apparatus for treating a tooth is disclosed. The apparatus can include a chamber having an access port which places the chamber in fluid communication with a treatment region of the tooth when the chamber is coupled to tooth. A fluid motion generator can be coupled to the chamber. The fluid motion generator can be configured to direct fluid across the access port to generate fluid motion in the chamber. In various embodiments, fluid motion (e.g., vortices, swirl, etc.) can be induced at or near treatment regions of the tooth, such as a root canal or carious region.

Abstract: The invention relates to a neovaginal prosthesis formed by an essentially cylindrical hollow main body comprising a closed upper end and an open lower end, and a securing plate intended to connect to the lower end of the main body.

Abstract: Disclosed is a device for transporting a biopharmaceutical fluid, including an inner bag forming an inner chamber adapted and intended for receiving a biopharmaceutical fluid, an outer container including an outer receptacle, the outer receptacle including a wall forming an outer chamber, an expandable protective element arranged at least partially between the outer receptacle and the inner bag and adapted to receive the inner bag, the expandable protective element being adapted to expand in volume to an expanded state so as to be interposed between the outer receptacle and the inner bag, the expandable protective element in the expanded state surrounding the inner bag and filling the space between the wall of the outer receptacle and the inner bag.

Abstract: A catheter is provided with a distal portion, a proximal portion, and a plurality of drainage eyes disposed at a junction between the distal portion and the proximal portion. The distal portion includes a tip, a plurality of elongated ribs, and a plurality of external flow paths. The proximal portion includes an internal lumen and a proximal end. The plurality of drainage eyes communicate with the plurality of external flow paths and the internal lumen.

Abstract: A dilation cap may include a distal tip, an intermediate body, and a proximal coupling member. The distal tip may at least partially surround a longitudinal axis of the dilation cap and may include a cavity to receive a distal end of a cannula of a medical device. The intermediate body may extend proximally from the distal tip and include a dilator portion. The dilator portion may include a projection extending laterally in a direction away from the longitudinal axis of the dilation cap. The proximal coupling member may extend proximally from the intermediate body and at least partially surround the longitudinal axis of the dilation cap. The proximal coupling member may be configured to engage an intermediate portion of the cannula of the medical device. The intermediate body may be asymmetrical with respect to the longitudinal axis of the dilation cap.

Abstract: A catheter has an entrance opening defined by the first end of a catheter body and non-circular inner surface in cross section. The entrance opening intersects a longitudinal axis extending longitudinally through the center of a lumen adapted to drain urine from a bladder. The non-circular inner surface can have dimples, channels, or grooves, all of which decrease frictional fluid forces against the inner surface as the urine drains. The catheter is free of any eyelets formed in the side wall of the catheter body. The catheter further includes a plurality of distinct longitudinally extending convex outer surfaces and may have an enlarged head.

Abstract: A pump dispenser is intended for oral administration of medicines. A pump receives fluid product through a valved inlet from a container, preferably of the airless type with a follower piston. The dispenser may be a movable-nozzle or fixed-nozzle dispenser. The discharge outlet of the dispenser has a stub nozzle incorporating a closure valve. A spring urges the closure valve forward to close a discharge opening of the stub nozzle. The nozzle attachment is shaped for oral dosing and has an internal rearwardly-projecting actuating structure which, when the nozzle attachment is coupled onto the stub nozzle, pushes the closure valve open. When the nozzle attachment is removed the spring closes the outlet again. Child-resistant features are described for fitting the nozzle attachment to the stub nozzle.

Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece.

Abstract: This invention describes the administration of multiple therapeutic agents with insulin in conjunction with bexarotene, ketamine, monoclonal antibodies Etanercept, IGF-1, and acetylcholine esterase inhibitors physostigmine, for treatment of Alzheimer's disease and other neurodegenerative diseases. Insulin, improves memory; also augments and amplifies the effects of the adjuvant therapeutic agents (paracrine and intracrine effects) and consequently reduces the ? amyloid, its soluble precursors, prevents damage to the neuronal skeletal network (taupathy), and blocks glutamate excitotoxicity, reduces brain inflammation, prevents apoptosis, and increases the acetylcholine levels in the neurons and synapses; by using a combination of insulin, bexarotene, ketamine, Etanercept, IGF-1, and physostigmine therapeutic agents.

Abstract: An ear medication delivery device for delivering a treatment liquid and retaining the treatment liquid within an ear canal of a patient.

Abstract: A pet ear cleaning device is disclosed for gently cleaning an animal's ears. The device can be used for home or veterinary use. The pet ear cleaning device comprises a nozzle, a liquid reservoir in fluid communication with the nozzle, an internal pump assembly, and a tip for cleaning a pet's ear. A user would press a manual dispensing component which would activate the internal pump assembly which would then draw fluid from the liquid reservoir and transfer it to the nozzle. The liquid reservoir is typically a reusable reservoir that a user would re-fill with ear cleaning solution when empty, or it can be a replacement cartridge. Further, the nozzle typically comprises threads on its end for retaining the cleaning tip on the nozzle. After use, a user would discard the tip via a manually operated discard component that allows a user to remove the soiled tip hands free.

Abstract: A water jet spray nozzle has a flow path including, from the upstream side to the end of the flow path, a small-diameter portion having a small inside diameter, an expanded portion having a larger inside diameter than the small-diameter portion, and a jet orifice having a smaller inside diameter than the expanded portion. The water jet spray nozzle is configured such that water passing through the flow path with a pressure of 0.2 to 0.6 MPa is retained in the expanded portion to as to generate cavitation bubbles from the small-diameter portion to the expanded portion. The inside diameter of the small-diameter portion § is 0.5 to 0.7 mm while the inside diameter of the jet orifice is 1 to 1.3 times larger than that of the small-diameter portion.

Abstract: A pump for use in anal irrigation includes a control unit integrated in the pump. The control unit includes a cylindrical housing element and a valve element fitted in the housing. The valve element and the housing element are adapted for rotating with respect to each other between a position allowing the pump to pump air into a balloon, a position allowing the pump to pump air into a reservoir bag and an evacuation position. The control unit is actuated by a handle attached to the rotatable valve element. The handle extends radially out from the rotatable valve element and the cylindrical housing.

Abstract: A device for delivering a medicament to a patient in need thereof includes: (a) an injector including a first end configured to remain outside a nasal passage of the patient and a second end configured for entry into the nasal passage of the patient, wherein the injector is moveable between a storage position and an engaging position; and (b) an introducer configured for engagement with a nostril of the patient, wherein the introducer includes a passageway configured for slidably receiving the injector, and wherein the introducer includes a curvature along a portion thereof adjacent to the passageway. Methods for ameliorating pain in a patient include (a) introducing the injector through the nasal passage of the patient into a region substantially medial and/or posterior and/or inferior to a sphenopalatine ganglion of the patient; and (b) delivering a medicament from the injector superiorly and/or laterally and/or anteriorly towards the sphenopalatine ganglion.

Abstract: A method for delivering medicament such as for ameliorating pain in a patient includes introducing an injector through a nasal passage of the patient into a region substantially medial and/or posterior and/or inferior to a sphenopalatine ganglion (SPG) of the patient; and delivering a medicament from the injector superiorly and/or laterally and/or anteriorly towards the SPG. A device for delivering a medicament to a patient in need thereof includes (a) an injector containing a first end configured to remain outside a nasal passage of the patient and a second end configured for entry into the nasal passage of the patient; and (b) an introducer configured for engagement with a nostril of the patient and containing a passageway configured for slidably receiving the injector. The injector is moveable between a storage position preceding the engagement and an engaging position pursuant to the engagement.

Abstract: The present disclosure describes a gastric jejunal tube having a gastric lumen and a jejunal lumen that run the length of the tube. The cross-sectional sizes of the lumens change from above to below the most distal gastric port. A method of making the gastric jejunal tube is also described.

Abstract: An enema includes a liquid in a dispenser having a bottle, a nozzle attached to the bottle, and a valve. The valve may be a membrane having a slit and a thickness of at most 0.90 mm. The valve may be attached to the bottle or it may be attached to the nozzle. The enema can be administered more easily, with a lower amount of force. A method of bowel cleansing includes inserting the enema into a rectum and applying a compression force to the enema bottle.

Abstract: An ear medication delivery device for delivering a treatment fluid and retaining the treatment fluid within an ear canal of a patient. The ear medication delivery device can retain the treatment fluid in contact with the ear canal or an eardrum of the patient for a desired time period to provide a therapeutic benefit. In some embodiments, an earplug device can be provided in several sizes for an optimal sealing fit in the ear canal.

Abstract: A device for nasal lavage is described. The device ejects a gentle flow of fluid under pressure. The fluid stream provides a high quantity of fluid at low pressure. The low pressure fluid stream is more comfortable for a user than a high pressure fluid stream that is delivered by some types of pressurized cans of solution.

Abstract: Formulations and methods of manufacture are provided for granisetron dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations. Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices.

Abstract: Systems and methods of removing bacterial biofilm from a target site using a biofilm removal endoscope. The endoscope has an insertion portion including an imaging channel terminating at a viewing window and an irrigation channel terminating at a nozzle. The imaging and irrigation channels are permanently affixed relative to one another. The insertion portion is inserted into the patient, with a working end thereof being disposed proximate the target site. The target site is imaged and a flow of fluid is dispensed via the nozzle to mechanically remove bacterial biofilm from the target site.

Abstract: The present application discloses devices and methods for delivering a therapeutic compound to the olfactory epithelium of an animal or human. The device having one or more channels for imparting a circumferential and axial velocity to the discharged fluid, and an outlet that discharges an aerosol spray having a circumferential and axial velocity as it enters the nasal cavity of a user. The device is designed to displace the air in the upper nasal cavity in order to specifically deposit a therapeutic agent on the olfactory epithelium while minimizing pressure and discomfort experienced by the user.

Abstract: A nozzle for a nasal rinse device including a collar that forms a conduit. The collar is configured to attach the nozzle to the nasal rinse device. An outlet aperture defined by the collar is on a top portion of the nozzle. The nozzle also includes a skirt extending outwards and downwards from the collar, and an outer surface of the skirt is faceted.

Abstract: A method delivers an implantable device through the urethra and into the bladder. A deployment instrument is inserted into the urethra, the implantable device is inserted into the deployment instrument, and a stream of fluid is injected into the deployment instrument. The stream of fluid drives the implantable device from the deployment instrument into the bladder. The deployment instrument is removed from the urethra, leaving the implantable device wholly implanted in the bladder.

Abstract: A surgical tool that includes a tip with a smooth, rounded edges and free of any sharp edges. The tip may have pores on its top, but none on the underside of its base. The distal end may have an open port with micro wires that form a Maltese cross shape. The distal end may be instead closed with protrusions spaced from each other by gaps or recesses.

Abstract: A method and device for delivering medicament such as for ameliorating pain in a patient from an injector superiorly and/or laterally and/or anteriorly towards the sphenopalatine ganglion (SPG). A device for delivering a medicament to a patient in need thereof includes (a) an injector containing a first end configured to remain outside a nasal passage of the patient and a second end configured for entry into the nasal passage of the patient; and (b) an introducer configured for engagement with a nostril of the patient and containing a passageway configured for slidably receiving the injector. The injector is moveable between a storage position preceding the engagement and an engaging position pursuant to the engagement. The device may further include a locking connection assembly that is useful in other devices.

Abstract: Applicators 470,472, 474, and 475 include a body with a stem 174 having an axially-formed slot delivery passage 200. Slot 176 is formed transaxially through stem 174 in communication with slot delivery passage 200. Proximal and distal transition surfaces 176e and 176g are formed at axial ends of slot 176. Stem 174 of applicator 470 is tapered axially distally inward. Flat surface 276 may be formed adjacent slot 176. The body is formed with flange 172 having a seat for receipt of a vagina or anus of a patient. Stem 174 of the applicator 474 is curved away from a normal axis of the body. Stem-like proximal section 174a of the body of applicator 475 is curved away from the normal axis of the body, with a distal end of the section integrally joined with a proximal end of the straight stem 174.

Abstract: A high flow volume nasal irrigation device includes a squeeze bottle, a reservoir of liquid and a volume of air. The bottle is configured to elastically deform in response to a manual pressure from a user and thus pressurize the liquid and air. The device also includes a dip tube configured to convey a pressurized liquid flow from a first end inside the bottle to a second outside end at a lower pressure. A removable nipple cap comprises an orifice and a coaxially aligned extension configured to seal with the dip tube and to form a conduit with the tube. At least one air metering orifice is formed in the fluid conduit accessible to the to volume of air. The air metering orifice is configured to introduce a plurality of air pockets from the air volume into the liquid flow and thus generate a pulsatile fluid flow in the conduit.

Abstract: A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.

Abstract: A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.

Abstract: The device is essentially a pipette with pre-filled medication in it. Also, there is an additional plug with pressure release valves on the tip of the pipette. The pre-filled medication prevents licensed practitioners from having to count drops and having to fill the pipette up, thus saving time. The plug on the tip fits snuggly into the ear canal helping the practitioner find the perfect spot in the ear canal. Pressure relief valves in the plug helps relieve pressure in the ear canal when delivering treatment, helping for a safer treatment. The plug on the tip of the pipette also has openings on the side to deliver treatment thus coving a wider spectrum of the ear canal, and creating a more beneficial treatment.

Abstract: A method is provided for increasing blood flow in or about a cardiac structure to prevent thrombosis. One step of the method includes providing an implantable sprayer having an elongated tubular body with proximal and distal end portions. The distal end portion includes at least one opening and an anchoring mechanism. The distal end portion of the implantable sprayer is inserted into a cardiac chamber that includes the cardiac structure. The anchoring mechanism is then deployed so that the distal end portion of the implantable sprayer is secured in or about the cardiac structure. Next, the proximal end portion is anastomosed with an artery so that blood flows through the elongated tubular body of the implantable sprayer and is sprayed out of the at least one opening to continuously circulate blood in or about the cardiac structure.

Abstract: Provided is a bladder drainage aid which attaches to the end of Foley Catheter and removes the need for a catheter bag. In a preferred embodiment, the device is a spring-loaded valve with an inflow tube and an outflow tube. The inflow tube connects to the external end of a catheter. The outflow tube can be aimed by the patient. When pressed, the valve opens, allowing the fluid to flow there through. When released, the piston of the valve cuts off fluid flow. The valve cap allows ease of use and the device can be operated with two fingers of one hand. The patient can wear the drainage aid discretely and empty the bladder directly and discretely, such as into a toilet.

Abstract: An ear medication delivery device for delivering a treatment fluid and retaining the treatment fluid within an ear canal of a patient. The ear medication delivery device can retain the treatment fluid in contact with the ear canal or an eardrum of the patient for a desired time period to provide a therapeutic benefit.

Abstract: Methods and apparatus for a syringe adapter. In one embodiment, an adapter/cap assembly is threadably engaged to a syringe for enteral feeding applications. The adapter cannot be removed from the syringe to prevent the syringe from being used for IV applications.

Abstract: A lavage catheter for the treatment of a maxillary sinus is described. The catheter comprises a proximal portion and a distal portion. The distal portion comprises an irrigation tip. The irrigation tip has a tip opening through which fluid may be delivered by one handed operation of the catheter. A method for lavaging the maxillary sinus includes inserting the lavage catheter into a patient's anatomy and advancing the irrigation tip into the maxillary sinus using one hand.

Abstract: A device and method for dilating a Eustachian tube of a patient is disclosed. The device includes a guide catheter and a balloon dilation catheter. The balloon dilation catheter has an actuator that prevents injury to the middle ear. The balloon dilation catheter is slidably coupled with the guide catheter through the guide catheter lumen and is fully inserted into the guide catheter lumen when the distal side of the actuator is adjacent to the proximal end of the guide catheter. The method involves advancing the guide catheter and balloon dilation catheter through a nasal passage of the patient to dilate a portion of the Eustachian tube.

Abstract: A catheter based drug delivery system for minimally invasive delivery of treatment drugs into a bladder wall. The catheter system can include a delivery tip for deforming the bladder wall before forming jets of drug solution that penetrate the bladder wall for needleless delivery of the treatment drugs directly to the diseased tissue. The delivery tip can also have graduated markings for providing visual indicators of the relative depth of the delivery tip in the bladder wall and the alignment of the formed jets with the particular layers of the bladder wall.

Abstract: Enteral safety system (ESS) may include syringe having visual indicator such as barrel with measurement marks of a color. Barrel may allow content viewing. ESS may include hub for connecting syringe to enteral set. Hub may have a visual indicator such as being same color as barrel's marks. Enteral tubing or set may have a visual indicator such as a lengthwise stripe same color as barrel's marks. Enteral tubing may allow content viewing. ESS may include an enteral tubing-feeding tube hub for connecting enteral tubing to a feeding tube. This hub may have visual indicator such as same color as barrel's marks. Feeding tube may have visual indicator such as a lengthwise stripe same color as barrel's marks. Feeding tube may allow content viewing. The syringe, syringe-enteral tubing hub, enteral tubing, enteral tubing-feeding tube hub, and feeding tubing are properly connectable by reference to visual indicators such as color matching.

Abstract: The device for rectal lavage includes a generally rigid tubular body (10) having a relatively flexible tapered front end nozzle portion (12) for insertion into the anus (50) of a patient. A port (14) is provided for the insertion of an irrigation hose (16) into the device, which passes through a nozzle opening (18). At least one drain hole (20) is positioned in said nozzle (12), spaced from said opening (18), for the passage of irrigated fecal matter from the rectum (52) into the hollow interior (24) of said tubular body (10). A discharge outlet (22) member from the hollow interior (24) of said tubular body (10) for the discharge of irrigated fecal matter from the device.

Abstract: A valve for controlling fluid flow through a flow passage. The valve includes a tubular valve body defining a longitudinal axis and having an interior surface and an exterior surface. The valve body defines first and second valve ends and a tip portion is supported on the valve body and located at the second valve end. A cap member is supported on the valve body and includes a closed end formed by an end wall having an aperture for receiving the tip portion. The aperture includes a lip portion surrounded a groove on an interior of the cap member to facilitate a pressure seal between the aperture and the tip portion.

Abstract: Sealing device for sealing externally debouching, natural or artificial body canals of animals or human beings, the device enabling liquid tight sealing against the inner wall of the bowel system of the animal or human being, the device further being made from a resilient material. The device is soft and resilient and may thus not trigger the analreflex, but is still able to provide a fluid-tight seal.

Abstract: A colonic lavage catheter includes a head attached at an end of a suction tube and having both rearward and lateral fluid discharge openings. A pair of tubes extend along the suction tube with their ends attached to the head to place the rearward and lateral fluid discharge openings in fluid communication with a source of pressurized fluid. The suction tube includes a plurality of suction orifices through the outer wall along its length proximate the catheter head. A cleaning process may be performed by inserting the catheter head into the colon and then discharging fluid through the rearward openings to advance the catheter. At points along the colon, pressurized fluid may be discharged through the lateral discharge openings to lavage the adjacent walls of the colon, with suction being applied to draw the dislodged material into the suction tube through the suction orifices.

Abstract: An applicator for use with an ultrasound transducer assembly is disclosed. In an embodiment, an applicator includes a nozzle body having an interior and an exterior surface; a nozzle liner having an interior and an exterior surface and being engageable with the nozzle body such that a plurality of channels are defined at least in part by the exterior surface of the nozzle liner and the interior surface of the nozzle body, each of the plurality of channels having an inlet and an outlet; a passageway defined by a space between the nozzle body and the nozzle liner, in fluid communication with the inlets of each of the plurality of channels; and an opening sized and shaped for introducing fluid to the passageway to provide fluid flow from the outlet of each of the plurality of channels essentially simultaneously. Kits and methods are also disclosed.

Abstract: An irrigation catheter for the treatment of the sinus anatomy is described. The catheter comprises a proximal portion, a rigid middle portion, and a flexible distal portion. The flexible distal portion comprises an irrigation tip and the proximal portion has a stiffness that is intermediate the stiffness of the rigid middle portion and the flexible distal portion. The irrigation tip has a tip opening and one or more radially facing openings. A method for irrigating or suctioning the sinus anatomy includes inserting an irrigation catheter into a patient's anatomy and irrigating or suctioning a target space.

Abstract: A vessel for use in rinsing a user's nasal cavities includes a main body, a spout extending from the main body, a nozzle attached to the spout, and a handle forming an aperture in communication with the main body. The aperture is sealable by a user to control a flow of a fluid held in the main body out of the nozzle. The nozzle defines an outer skirt deflectable upon engagement with the walls of the user's nasal cavity. A lid is removably engageable with the main body, provides fluid ingress when removed, and creates a watertight seal between the lid and the main body when engaged with the main body. An annular raised periphery may surround the aperture for facilitating sealing of the aperture with the user's finger.

Abstract: A method for irrigating a paranasal sinus may involve advancing a distal portion of a sinus irrigation catheter through an ostium of a paranasal sinus into the sinus and passing fluid through multiple ports disposed at different locations along a length of the catheter distal portion into the sinus. A flexible irrigation catheter device for irrigating a paranasal sinus may include: an elongate catheter body having a proximal end, a distal end, a lumen therebetween, and a tapered distal portion extending proximally from the distal end of the catheter body; a proximal hub coupled with the proximal end of the catheter body for connecting to a source of irrigation fluid; multiple side ports disposed along the catheter body closer to the distal end than the proximal end and in fluid communication with the lumen; and a distal end port at the distal end of the catheter body.