Abstract: A container for re-suspending sedimented medicament comprises a reservoir for containing a suspension of particles in a liquid, a dispensing portion, and a sealing portion. The sealing portion is arranged to be in fluid communication with the reservoir via an orifice. The orifice is positioned between the dispensing portion and the sealing portion, and allows a turbulent flow of the liquid from the reservoir into the sealing portion to enable re-suspension of particles that have sedimented out of the liquid in the sealing portion.

Abstract: A port assembly for establishing fluid communication between a first container and a second container. The port assembly includes a port housing for connection to a second container, and a retainer for connection to a first container, wherein the retainer rotates relative to the port housing and is constructed to move axially within the port housing. An actuator is axially fixed within the port housing and forces a stopper associated with a first container into a first container when the retainer moves axially within the port housing upon rotation of the retainer relative to the port housing. The assembly is configured to establish fluid communication between a first container and a second container upon rotation of the retainer relative to the port housing.

Abstract: A self standing bag having two side wall sheets and a bottom sheet. To flatten the bag, the bottom sheet is sandwiched between the two side wall sheets and symmetrically folded along a line parallel to its bottom edge, separating the bag into a four-layer part and a two-layer part. In the two-layer part, the bag includes first sloped sealing lines extending between a first two points on the top edges of the side wall sheets and spaced from the vertical side wall edges by a first distance, to a second two points spaced from the vertical edges of the side wall sheets by a second distance less than the first distance. The four-layer part includes second sloped sealing lines extending between the second two points and a third two points on the bottom edges of the side wall sheets.

Abstract: A connector according to the invention includes a first connection region for connecting a first container, a piercing element and a break-open element, wherein the piercing element has a first end section and a second end section and a channel, running from the first end section to the second end section, for transporting a medicinal active substance, wherein the first end section is formed for piercing a membrane of the first container connected in the first connection region, and, at the second end section, the break-open element is attached such that it can be broken open and/or broken off, wherein, in the attached state, the break-open element seals the channel of the piercing element in liquid tight fashion.

Abstract: To provide a drug solution preparing kit which can be handled with ease in a substantially aseptic manner, and has no risk that a leakage of a drug solution such as a splash and a dispersion of an aerosol to an ambient environment occurs upon preparation of the drug solution There is provided a drug solution preparing kit including a pre-filled syringe and a transfusing tool, wherein the pre-filled syringe includes a sealing member which seals the tip end and can not be removed from the tip end, and that the transfusing tool includes a one-way valve which can discharge only gas from the system in an irreversible manner, and a filter which is provided so as to adjoin to the second communication channel with respect to the one-way valve.

Abstract: A system for mixing contents of a first container with contents of a second container. The system includes a first container, a second container, a device for establishing fluid communication between the first container and the second container, and a hanger for hanging the system, wherein the hanger is operable only when fluid communication between the first container and the second container has been established. The system can be used in a method for preventing medication delivery errors.

Abstract: An automated syringe filler is disclosed comprising a housing and motor with a rotatable syringe holder plate that can be raised and lowered onto exposed syringe needles. The housing also has components for one or more syringes to be attached with the needles pointing upward and the syringe plungers moveably positioned at the bottom. The syringe plunger tool controls the movement of the syringe plunger and can be horizontally and vertically positionable. The syringe plunger tool is motorized and can be controlled by a CPU or similar device containing programmable media.

Abstract: A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.

Abstract: The invention comprises a novel apparatus for delivering a nutritive substance comprising a container body having a base at one end thereof, an upper portion adapted for removable receipt of a closure, the upper portion defining an opening therein, and a chamber defined by the container body, the chamber being in fluid communication with the upper portion opening. A seal is bonded across the upper portion opening of the container and is adapted to provide an airtight seal across the opening. A closure is removably coupled to the container upper portion. A nutritive substance is coated onto an element selected from the group consisting of an inner surface of the container upper portion, the closure, an insert positioned above the seal, and combinations thereof. The seal prevents contact between the nutritive substance and the contents of the container until the seal is removed or pierced.

Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.

Abstract: A first connector is provided and includes a first connector body having a cylindrical outer tube, a cylindrical inner tube, and a hub; a hollow needle supported by the hub; a first sealing member supported by the inner tube; a coil spring that biases the hub in a proximal direction and biases the first sealing member in the distal direction; and gripping and pressing members disposed on the outer tube. A plurality of pawls are formed on a flange of the hub. A plurality of ratchet teeth are formed on an inner circumferential portion of a proximal portion of the outer tube. Each of the ratchet teeth and each of the pawls of the hub form an engagement-disengagement mechanism.

Abstract: The present invention relates to a closure for filling and sealing receptacles containing medicinal fluids, a method for filling a receptacle with a medicinal fluid and sealing the receptacle. The closure used in the method comprises a mounting piece that may be attached to the receptacle and a connector piece that may be connected to a connector piece of a filling device. A closure body is arranged between the mounting piece and the connector piece, in which a closure piece for sealing the closure sits. The closure piece may be slid between a position sealing the closure and a position which opens the closure. The closure is sealed tight with a removable protective cap. The present method is characterized in that with the protective cap removed the receptacle is filled through the closure in a clean room, whereupon after filling, the closure is sealed by pressing the closure piece into the closure.

Abstract: A dispensing insert is configured to friction fit within a neck of a bottle and to selectively receive an oral syringe. The dispensing insert includes a hollow cylinder, a top plate capping one end of the hollow cylinder, a raised deck extending substantially parallel to and spaced from the top plate, and an annular side wall extending from the top plate upwardly toward the raised deck. The raised deck has a smaller outer diameter than the top plate and defines an opening therethrough configured to provide access to contents of the pharmacy bottle through the dispensing insert. The annular sidewall substantially encompasses an outer perimeter of the raised deck.

Abstract: A fibrin wound dressing is made by mixing quantities of fibrinogen solution and thrombin solution with air. The resulting foam is very light weight, and with the proper attention to the amount of thrombin, is also sufficiently viscous to rest on a vertical surface without dripping. The wound dressing may also be formulated for its ability to continue migration of healing substances, such as PDGF, from the dressing to the wound site. Thrombin substitutes, such as other clotting proteins, may be used instead of thrombin. The resulting foam may also be lyophilized or ground and lyophilized for later reconstitution. A therapeutic drug or other additive may also be added to the wound dressing.

Abstract: A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

Abstract: A liquid component collecting device capable of more easily collecting a liquid component. A liquid component collecting device (100) is provided with: a flexible cylindrical liquid component storage container (21) having an opening at one end thereof; a cylindrical first housing container (22) for housing the liquid component storage container (21) and having an opening at one end thereof; and a first cap (23) connected to the opening in the liquid component storage container (21) and fitted to the opening in the first housing container (22). A pressure regulating space (26) independent of the internal space of the liquid component storage container (21) is formed between the outer side of the liquid component storage container (21) and the inner side of the first housing container (22).

Abstract: The invention refers to a new system for packaging pharmaceutical compositions comprising active principles that may be administered intravenously, in particular it concerns a system for packaging in bottles which makes it possible to ensure the complete transfer of the content of the bottle into the liquid for intravenous infusion and at the same time prevent any accidental contact with the active principle by the health-care personnel preparing said intravenous infusion, and a complete kit for intravenous administration.

Abstract: An ampoule including a casing, a facing side and a seal, wherein the casing has an outer diameter and the seal extends radially beyond the outer diameter and seals the facing side.

Abstract: A system for mixing or reconstituting agents including engageable syringe barrels, one of which having a male engagement region and the other a female engagement region. Each of the male and female engagement regions is provided with a screen. The screens are closely spaced from one another when the first and second syringe barrels are engaged with one another. The screens may take the form of a mesh, a plurality of protuberances, or cantilevered wedges having tapering thicknesses.

Abstract: Methods, apparatuses, kits and systems are disclosed that allow a transfer of medication from a manufacturer's vial, ampoule or other container through a closed system transfer to an intravenous apparatus and into a patient, while reducing additional steps, procedures, components required for the same transfer procedure to reduce sources of human error and medical administered errors.

Abstract: A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.

Abstract: Device for connecting a tubular part having a first end provided with a tip, and a second end provided with a connecting device. The connecting device connects an inside of the tubular part with a syringe and with the inside of a bottle, which bottle includes a neck having a stopper penetrable by the tip of the tubular part. Device includes a supporting device for sealing and fitting the device into place on the neck of the bottle in a tight and substantially centered manner. A holding device holds the tubular part in a displaceable manner relative to the supporting device in a penetration direction of the tip of the tubular part. Holding device includes a tight, deformable membrane with two edges, one edge of which is connected tightly to the tubular part and another edge of which is connected tightly to the supporting device.

Abstract: A fluid transfer assembly including a vented female vial adapter and male vial adapter for use with a pair of vials including a vial with contents under negative pressure for liquid drug reconstitution and administration purposes. The vented female vial adapter includes a venting arrangement and the male vial adapter includes a sealing arrangement for selectively sealing the venting arrangement. The fluid transfer assembly is designed such that only filtered air is drawn into the vial under negative pressure subsequent to reconstitution of liquid drug contents to ensure sterile conditions.

Abstract: A computerized method of providing patient treatment values in real time, including the steps of providing a computer database having a plurality of predetermined patient selection criteria, patient condition categories, and drug selection, dosing values and related information, and providing an input device in communication with the computer database for inputting one or more of the patient selection criteria, patient condition categories and drug selection and dosing values and related information. A computer display in communication with the computer database and the input device is provided for displaying precalculated dosing values based on one or more inputted patient selection criteria, patient condition categories and dosing values and related information. One or more of the patient selection criteria, patient condition categories and treatment type is input by the input device into the computerized database provided in step (a) and associating a unique identifier with the inputted information.

Abstract: An apparatus for the handling of hazardous fluids includes a collection vessel, a collection vessel connector, a dose control connector, a unit dose container, a delivery control connector, and a delivery site access device. The collection vessel contains the fluid prior to dispensing, the unit dose container contains a predetermined amount of the fluid for dispensing, the delivery site access device provides access to an intended delivery site, and the connector attaches pieces of the apparatus to one another. The method of the invention allows needle-free connections to be made for the apparatus, using a predetermined arrangement of the pieces of the apparatus, and in one embodiment, employs deformable elastomeric valves capable of creating a decreased pressure at a valve surface, so that upon closure of said valves, a fluid on the surface on the valves is withdrawn within the connector.

Abstract: A device for providing sterilized or cleaned fluid to a receptacle and thereby facilitate conveyance of a substance out of the receptacle, comprising a connector and a container which form an integrated unit. The connector is provided with a first means for connection to a receptacle. Sterilized or cleaned fluid is transferred from the container to the receptacle.

Abstract: A system includes a cylinder having a bore with a piston disposed therein, the piston moveable along the bore of the cylinder and having a passage therethrough. The system also includes a mixer disposed in the passage in the piston and including at least one porous mixing device, the at least one porous mixing device comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and having physical characteristics to sufficiently mix the first and second components, which characteristics include a selected one or more of mean flow pore size, thickness and porosity.

Abstract: A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.

Abstract: A system for delivering an oxygen carrier, whereby a deoxygenated oxygen carrier can be oxygenated and efficiently delivered to an ischemic tissue, an oxygenation device for an oxygen carrier, and a housing for an oxygen carrier. A system for delivering an oxygen carrier, the system including: a housing in which a hemoglobin-based oxygen carrier is housed in a deoxygenated state; an oxygenation part for oxygenating the deoxygenated oxygen carrier; and a long element which can be inserted into a living organism and can release the oxygenated oxygen carrier through a lumen that is formed inside thereof.

Abstract: The present invention relates to a connector for a replaceable container to be used in a medical machine, which is comprised by at least a body, the inner side of which is traversed by inlet and outlet tubes extending from within such container towards an outer side of the connector, wherein said tubes separately extend leading to two laterally spaced-apart apertures that are removably attachable to a mounting means and supplementary connection of said machine.

Abstract: The invention relates to an arrangement for use with a medical device which arrangement comprises a shield for a tip of a needle member of a medical device. The arrangement comprises a filter for filtering gas to be transferred out from or into the medical device via the needle member when the arrangement is interconnected with the medical device. The filter is integrated with or constitutes at least a portion of the needle member tip shield.

Abstract: The present invention is directed toward fluid transfer devices including a vial adapter having a top wall and a cannula with a cannula tip, and an elastic O-ring like sealing element sealingly encircling the cannula and initially disposed towards the cannula tip and spaced apart from the top wall, the sealing element being brought into initial contact with the vial stopper subsequent to the cannula tip contacting the vial stopper at a puncture site and thereafter being slidingly urged towards the top wall and continuously sealing the puncture site during snap fit mounting the vial adapter on the vial.

Abstract: A multilayer plastic container for storing lyophilized products includes at least three layers consisting of inner and outer layers having a moisture vapor transmission rate of not more than 0.1 gm mil/100 sq. in.-day at 73° F. and 95% rh, and an intermediate layer of hygroscopic resin construction having a moisture content less than 1000 ppm. The hygroscopic intermediate layer preferably comprises at least 30% of the total thickness of the three layers. The inner and outer layers preferably are of cyclic olefin polymer or cyclic olefin copolymer construction, and the hygroscopic intermediate layer preferably is of amorphous nylon construction. The container preferably is empty and sealed within a secondary container, such as a metallized bag, that is impervious to moisture.

Abstract: A container for use in dialysis, containing a certain amount of a salt concentrate in the form of a powder, granules or tablets or mixtures thereof, having an inlet for the water and an outlet that is connectable to a dialysis machine. Both the inlet and the outlet are situated on one side of the container, and each includes a filter therein to prevent any undissolved salt concentrate from leaving the container.

Abstract: A device for automatically delivering a drug to a user and method thereof are disclosed. The device (10, 20, 70, 110) provides a connector to which a vial (12, 50, 60, 100, 130, 202) containing the drug is removably connected and situated thereto in a substantially inverted position. When commanded by the user, the device (10, 20, 70, 110) starts a reconstitution process to automatically create a reconstituted drug, and provides an indication that the reconstitution process is complete such that the vial (12, 50, 60, 100, 130, 202) may be removed from the connector (22, 72,112). After disposing the device (10, 20, 70, 110) on the user, the device (10, 20, 70, 110) can automatically deliver the reconstituted drug to the user when further commanded by the user.

Abstract: A fluid transfer assembly, drug container, and method for enabling fluid transfer in an infusion system is taught. The assembly includes a fluid container containing an infusion fluid, and a drug container. The fluid container has at least one inlet port for receiving a medical substance from the drug container. The assembly further includes at least one fluid barrier controlling fluid passage between the drug container and the fluid container. The inlet port exhibits a first luer-lock connector, and the drug container is sealed by a cap exhibiting a second luer-lock connector for attachment to the first luer-lock connector. The fluid barrier is designed and arranged to be ruptured by an external force to allow the fluid passage.

Abstract: A connector (1) that can be connected to a first container and a second container (20) to transfer a liquid between the first container and the second container (20) includes a first connecting portion (3) that is engageable with the first container and a second connecting portion (4) that is engageable with the second container (20). The second connecting portion (4) is integrally provided with an engagement portion that is engageable with the second container (20) and a needle-like portion (7) for piercing into the second container (20). Thus, it is possible to prevent a container from falling off during liquid transfer. Also, since the needle-like portion (7) is integral with the second connecting portion (4), connection to the second container (20) is facilitated.

Abstract: A fluid management system for transferring fluid, the system including a connector component comprising a first end and an opposite second end, a first syringe with a distal end that is removably attachable to the first end of the connector component, and a second syringe with a distal end that is removably attachable to the second end of the connector component.

Abstract: A needleless additive control valve for use with a fluid container containing an infusion liquid and having an intravenous (IV) port for administrating the infusion liquid, and an additive transfer device containing a liquid additive and having a male connector for administrating the liquid additive. The needleless additive control valve includes a trifurcated connector body having an IV spike for sealing insertion into the IV port, an outlet port, and a needleless additive port with a female connector for sealingly receiving the additive transfer device's male connector wherein the IV spike, the outlet port and the needleless additive port are in 3 way direct and continuous fluid communication thereby enabling the additive transfer device's liquid additive to be either mixed with the infusion liquid or directly administered to a patient.

Abstract: A coupling component is disclosed for transmitting medical substances, comprising two channels for conveyance of medical substances in two substantially opposite directions and a means for releasable connection to a second coupling component having a further channel for creating a coupling. The connecting means is a thread. A method for conveying medical substances to and from a container is also disclosed.

Abstract: A reconstitution assembly includes a housing including a lower sleeve and an upper sleeve, including a first container and a second container disposed vertically opposite the first container. A transfer set assembly is disposed within the housing between the first container and the second container. The transfer set assembly includes an upper spike housing and a lower spike housing, with a flow path defined through the upper spike housing and the lower spike housing. The transfer set assembly is configured to access contents of the first container and then upon the activation of a triggering mechanism, create a fluid pathway between the first container and the second container. The triggering mechanism includes trigger fingers which ensure the transfer set assembly sequentially accesses the contents of the first container before accessing the contents of the second container. The disposition of the first container activates the triggering mechanism.

Abstract: A method for the preparation of pharmaceutical products according to which a diluent is fed into a container containing a lyophilized or powdered pharmaceutical through a needle, which is then extracted from the container, inserted in its protective cap, and rinsed by feeding the diluent through the needle and into the protective cap itself.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A drug mixed system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one syringe adaptor adapted to be attached to a syringe and to the at least one receptacle port adaptor and at least one vial adaptor adapted for connection to a vial containing a drug and adapted for connection to the at least one syringe adaptor, the system being characterized in that at least one of the receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.

Abstract: A multivolume cartridge assembly having two or more internal compartments for storing and administering one or more medicinal compounds. In some embodiments, a second internal volume is positioned in the distal end of the cartridge assembly, and in other embodiments, the second internal volume is positioned in the apical end of the cartridge assembly. In some embodiments, the cartridge is configured to allow for long term storage of two or more medicinal compounds without mixing of the two or more compounds during storage. The cartridge, in some embodiments, utilizes a stopper assembly to create fluid communication between the two or more internal compartments of the cartridge and allow for mixing of the contents of the two or more compartments prior to the administration of those contents to a patient.

Abstract: The present invention relates to a connector device to connect a first and a second fluid container, directly or indirectly. The connector device exhibit a first and a second connection means, a pierceable barrier member, a piercing member, a fluid transfer channel and a pressure normalization channel. The pressure normalization channel is arranged to normalize an increasing pressure inside second fluid container. A valve arrangement permitting fluid to flow in a first and a second direction is arranged in the pressure normalization channel. The valve arrangement exhibit a cracking pressure in at least the first direction. The present invention provides for a connector device which reduces the risk of clogging the barrier filter.

Abstract: The invention comprises a novel apparatus for delivering a nutritive substance comprising a container body having a base at one end, an upper portion adapted for removable receipt of a closure, the upper portion defining an opening therein, and a chamber defined by the container body, the chamber being in fluid communication with the opening. A laminate seal having at least two layers is bonded across the opening and is adapted to provide an airtight seal across the opening and prevent contact between said nutritive substance and the contents of said container until said seal is altered. The laminate seal comprises a first layer permanently bonded to a rim defining the opening in the upper portion and a second layer that is releasably coupled to the first layer. A nutritive substance is bonded to the first layer. The container additionally comprises a closure removably coupled to the upper portion.

Abstract: Some embodiments disclosed herein related to a device for transferring precise amounts of fluid from at least one source container to a at least one target container. In some embodiments, the fluid is first transferred from the source container (e.g., a vial) through a connector to an intermediate measuring container (e.g., a syringe). In some embodiments air can pass through an air inlet and enter the vial to compensate for the volume of fluid withdrawn from the vial. An air check valve or a bag or a filter can prevent the fluid from escaping through the air inlet. The precisely measured amount of fluid can then be transferred from the intermediate measuring container to the target container (e.g., an IV bag). In some embodiments the connector can include a source check valve and a target check valve to direct fluid first from the source container to the intermediate measuring container and then from the intermediate measuring container to the target container.

Abstract: The present invention relates to a bag (1) for packaging a biological substance, such as animal semen, which is formed by two plastic walls (10, 11) assembled so as to define a pouch (P) for receiving said substance and that comprises a line (15) communicating with said pouch (P) a line for filling the same, this bag comprising in addition at least one pair of openings (3, 4) located on both sides of said line (15), in order to get hung, via these openings, to fingers that are complementary to a supporting device. This bag is characterized in that at least one of these openings (3, 4) has an oblong shape, extends perpendicularly to said line (15), and comprises an area forming a hard spot. The invention relates also to a strip formed by juxtaposing such bags (1), and an assembly comprised of a bag and a hanging support.

Abstract: One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).