Introduction Of Biologically Derived Compounds (i.e., Growth Hormones Or Blood Products) Including Cells Patents (Class 604/522)
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Publication number: 20080119946Abstract: Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot.Type: ApplicationFiled: December 6, 2005Publication date: May 22, 2008Inventors: Helen Marie Nugent, Elazer Edelman, Anupam Dalal, Steve Bollinger, Scott Epperly
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Publication number: 20080097384Abstract: The present invention provides a method for introducing nucleic acid (30) into cells of a region of the human or animal body, which method comprises substantially occluding an efferent vessel from said body region and introducing said nucleic into that body region under pressure via said efferent vessel and further apparatus for introducing nucleic acid into cells of a region of the body comprising: a reservoir for holding a liquid formulation which comprises said nucleic acid; a catheter tube in fluid communication with said reservoir for conveying said liquid formulation to said body region via an efferent vessel of said body region; pressure development means for pressurising the liquid conveyed by the catheter; and occlusion means (8) for substantially occluding said efferent vessel.Type: ApplicationFiled: March 29, 2005Publication date: April 24, 2008Inventor: Andrew Pacey
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Publication number: 20080086111Abstract: A fluid delivery system includes a source of an injection fluid including a source outlet. The system also includes a control system including a control system inlet in fluid connection with the source outlet, a control system outlet and, alternatively, an actuator. The control system is adapted to deliver a predetermined amount of fluid via the control system outlet upon activation of the actuator or modification of the control system. In several embodiments, the injection fluid in the source is pressurized. The source can, for example, include a plunger slidably disposed therein and a force application mechanism to place force upon the plunger and pressurize the fluid within the source. The control system can further include a metering volume in fluid connection with a valve system. The metering volume can include a plunger slidably disposed therein.Type: ApplicationFiled: October 9, 2007Publication date: April 10, 2008Applicant: MEDRAD, INC.Inventors: Kevin P. Cowan, Frederick W. Trombley
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Treatment of Conditions Involving Dopaminergic Neuronal Degeneration Using Nogo Receptor Antagonists
Publication number: 20080045926Abstract: The invention provides methods for promoting regeneration or survival of dopaminergic neurons in a mammal displaying signs or symptoms of dopaminergic neuronal degeneration, including a human with Parkinson's disease, using Nogo receptor antagonists.Type: ApplicationFiled: January 28, 2005Publication date: February 21, 2008Inventors: Jane K. Relton, Thomas M. Engber -
Publication number: 20080045941Abstract: An apparatus and method for performing surgery using plasma is described. In one exemplary embodiment, the apparatus includes a radiofrequency signal generator, a conditioning network coupled to the radiofrequency signal generator, and a catheter coupled to the conditioning network, the catheter including at least one electrode, such that the conditioning network conditions radiofrequency energy produced by the radiofrequency signal generator to create plasma at the at least one electrode of the catheter.Type: ApplicationFiled: August 13, 2007Publication date: February 21, 2008Inventor: Richard J. Fugo
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Publication number: 20080027413Abstract: A method of producing blood products in vitro and a method of treatment are provided. The methods include culturing isolated non-SV40 transformed mesenchymal stem cells with growth factors for a time sufficient to produce at least one type of blood products. A method of differentiating mesenchymal cells is also provided. The method of differentiating mesenchymal cells includes culturing isolated non-SV40 transformed mesenchymal stem cells in vitro with growth factors and producing at least one blood cell product.Type: ApplicationFiled: October 14, 2004Publication date: January 31, 2008Applicant: UNIVERSITATSKLINIKUM HAMBURG-EPPENDORFInventors: Claudia Lange, Ursula Gehling, Rolf Axel Zander
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Patent number: 7270655Abstract: An apparatus and method for providing autologous medical treatment to a patient. The apparatus is characterized by its provision of a harvest catheter operatively connected to a pump and a delivery catheter operatively connected to the pump downstream from the harvest catheter, whereby material from the patient's donor site may be delivered to the patient's treatment site. The method is characterized by surgically implanting at least a first end of the harvest catheter and at least a second end of the delivery catheter within the patient's body. The entire apparatus may be implanted within the patient.Type: GrantFiled: January 14, 2005Date of Patent: September 18, 2007Inventor: George J. Haidukewych
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Patent number: 6979308Abstract: A scaled-up multi-coaxial fiber bioreactor, and variations of this bioreactor. The device is characterized by a hollow housing and an array of from about 20 to about 400 modules of hollow fibers, where each module includes at least three coaxial semipermeable hollow fibers. The innermost fiber provides a boundary for an innermost compartment which is connected to inlet and outlet ports. Arranged coaxially around the central hollow fiber are several other hollow fibers with their respective compartments, each compartment defined by a respective annular space between adjacent fibers and each including inlet and outlet ports. An outermost compartment for permitting integral aeration is the space between the outer side of the outermost fibers and the inner side of the housing, and has inlet and outlet ports. The hollow housing has inlet and outlet manifolds and flow distributors for each of the compartments. In a preferred embodiment the bioreactor is used as an extracorporeal liver.Type: GrantFiled: June 5, 2000Date of Patent: December 27, 2005Assignee: University of North Carolina at Chapel HillInventors: Jeffrey M. MacDonald, Stephen P. Wolfe
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Patent number: 6958060Abstract: A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The molecule is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the molecule to enter the cell. In the case where nucleic acid is injected, the efficiency of transfer permits expression of protein encoded by the nucleic acid in an amount that exhibits systemic biological activity and which generates a robust immune response.Type: GrantFiled: July 14, 2003Date of Patent: October 25, 2005Assignee: Genetronics, Inc.Inventors: Iacob Mathiesen, Terje Lomo
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Patent number: 6899877Abstract: A process for inhibiting vascular proliferation separately introduces components into the eye to generate plasmin in the eye in amounts to induce complete posterior vitreous detachment where the vitreoretinal interface is devoid of cortical vitreous remnants. The process administers a combination of lysine-plasminogen, at least one recombinant plasminogen activator selected from the group consisting of urokinase, streptokinase, tissue plasminogen activator, chondroitinase, pro-urokinase, retavase, metaloproteinase, and thermolysin and a gaseous adjuvant to form a cavity in the vitreous. The composition is introduced into the vitreous in an amount effective to induce crosslinking of the vitreous and to induce substantially complete posterior vitreous detachment from the retina without causing inflammation of the retina.Type: GrantFiled: August 26, 2002Date of Patent: May 31, 2005Assignee: Minu, L.L.C.Inventor: Gholam A. Peyman
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Patent number: 6862479Abstract: One or more implantable system control units (SCU) apply one or more stimulating drugs and/or electrical pulses to a spinal section responsible for innervating the male reproductive organs. The SCU uses a power source/storage device, such as a rechargeable battery. If necessary, periodic recharging of such a battery is accomplished, for example, by inductive coupling with an external appliance. The SCU provides means of stimulating a tissue(s) with electrical and/or infusion pulses when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the SCU(s) and/or for the transmission of power. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes a sensor, and the sensed condition is used to adjust stimulation parameters.Type: GrantFiled: August 9, 2001Date of Patent: March 1, 2005Assignee: Advanced Bionics CorporationInventors: Todd K. Whitehurst, James P. McGivern
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Patent number: 6846306Abstract: A single cell electroporation assembly and method involve delivery of a substance into a single cell. The substance is combined into an electroporation fluid and placed into a container having a distal opening. The distal opening of the container is placed in proximity to a target cell. Electrical pulses are delivered between a first electrode which is at least partially disposed in the container, and a second electrode outside the cell, the cell being positioned between the distal opening and the second electrode. The electrical pulses induce temporary formation of pores in the cell membrane and the substance enters the cell through the pores by passive diffusion or by active electrophoretic motion.Type: GrantFiled: October 10, 2000Date of Patent: January 25, 2005Assignee: Cold Spring Harbor LaboratoryInventors: Kurt Haas, Wun Chey Sin, Ashkan Javaherian, Zheng Li, Hollis Cline
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Patent number: 6821264Abstract: A gene delivery device for localizing and enhancing the efficacy of gene transfer that provides a contact surface for contacting with a tissue site. By applying a pharmaceutical composition comprising a nucleic acid to a contact surface and contacting the contact surface to a tissue site, a greater than 10-fold increase in transduction efficiency is achieved. In one embodiment of the invention, the device comprises a housing in communication with a contact surface having multiple contact elements, and the pharmaceutical composition is applied to the contact elements through a lumen in the device.Type: GrantFiled: November 27, 2000Date of Patent: November 23, 2004Inventors: Gautam Khurana, Stephen James Russell, Zvonimir S. Katusic
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Patent number: 6805860Abstract: A process is described for cellular repair of failing tissue of an organ if a patient's body. In the process, a catheter is positioned to provide an entry point for stem cell injection at the proximal end of the central lumen of the catheter external to the body and an exit point from the central lumen at the distal end proximate the site of the failing tissue. Stem cells are then injected through the catheter to invade the failing tissue at the site, while local forces at the site are quelled from disrupting migration of the stem cells into the failing tissue, to enhance the concentration of the stem cells and the pressure arising from the injection at the site and thereby overcome any barrier between the site of the injection and the failing tissue. Preferably, autologous adult stem cells are used in the procedure.Type: GrantFiled: September 30, 2001Date of Patent: October 19, 2004Inventor: Eckhard Alt
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Publication number: 20040143238Abstract: A system forms a cardiac conduction block at a location in a heart of a patient without substantially ablating cardiac tissue. The system includes a delivery system coupled to a source of material that is substantially non-ablative with respect to cardiac tissue. The delivery system delivers the material to the location, and the material at the location forms a conduction block without ablating the cardiac cells there. The material may include living cells, such as for example skeletal myocytes, and/or may include a non-living matter such as biopolymers such as a fibrin glue agent, or collagen agents. An expandable member with needle assembly is used to deliver the material so as to form a non-ablative circumferential conduction block at a location where a pulmonary vein extends from an atrium.Type: ApplicationFiled: January 21, 2003Publication date: July 22, 2004Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Randall J. Lee
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Patent number: 6758828Abstract: An apparatus delivers an agent to a treatment region, the apparatus having an outer cannula or lumen that has an internal surface and an external surface, the external surface being substantially smooth to penetrate tissue whereas the distal end is tapered; an inner cannula, or lumen coaxial to the outer cannula, providing a common fluid path (that is the same fluid passes through both the inner cannula and outer cannula) at the distal end with the inner surface of the outer cannula; a source of fluid to be passed through the common fluid path, the source of fluid comprising at least a reservoir of nutrients and/or gases for maintaining cells contained in a lumen coaxial and internal to the inner cannula; a semipermeable membrane comprises the surface of the lumen, thus allowing controlled material transport across the lumen surface; a source of cells or other biologically active material mass flow connected to the proximal lumen so that the cells or other biologically active material can exit the distal portType: GrantFiled: December 10, 2001Date of Patent: July 6, 2004Assignee: Regents of the University of MinnesotaInventors: Bruce E. Hammer, Mark J. Conroy
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Patent number: 6746441Abstract: A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus having more than two electrodes. A three-step pulse process, e.g. collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means of repositioning cells between successive pulses is also provided. The apparatus can also provide a means to pulse cells at different temperatures and then after pulsing, let the cells recover for a specified residence time at another temperature.Type: GrantFiled: December 22, 1999Date of Patent: June 8, 2004Assignee: Genetronics, Inc.Inventors: Gunter A. Hofmann, Dietmar Rabussay
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Publication number: 20040106896Abstract: A system forms a cardiac conduction block at a location in a heart of a patient without substantially ablating cardiac tissue. The system includes a delivery system coupled to a source of material that is substantially non-ablative with respect to cardiac tissue. The delivery system delivers the material to the location, and the material at the location forms a conduction block without ablating the cardiac cells there. The material may include living cells, such as for example skeletal myocytes, and/or may include a non-living matter such as biopolymers such as a fibrin glue agent. An expandable member with needle assembly is used to deliver the material so as to form a non-ablative circumferential conduction block at a location where a pulmonary vein extends from an atrium.Type: ApplicationFiled: December 23, 2002Publication date: June 3, 2004Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Randall J. Lee, Karen Christman, Richard Sievers
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Publication number: 20040092907Abstract: A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The molecule is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the molecule to enter the cell. In the case where nucleic acid is injected, the efficiency of transfer permits expression of protein encoded by the nucleic acid in an amount that exhibits systemic biological activity and which generates a robust immune response.Type: ApplicationFiled: July 14, 2003Publication date: May 13, 2004Applicant: INOVIO ASInventors: Iacob Mathiesen, Terje Lomo
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Patent number: 6719738Abstract: The invention concerns a device for directly delivering an active substance within all or part of a human or animal tissue cell, characterized in that it is in the form of a hollow tube (1), whereof the walls in contact with said tissue are provided with perforations (5) and whereof the distal end (2) is sealed, while the proximal end (3) is shaped so as to receive removable closing means, said tube being capable of bearing a pressure of at least 50 bars.Type: GrantFiled: May 17, 2001Date of Patent: April 13, 2004Inventor: Henri Mehier
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Publication number: 20040054335Abstract: This is a method and an apparatus for the treatment or introduction of contrast fluids into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected treatment or contrast fluid to be confined to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.Type: ApplicationFiled: August 12, 2003Publication date: March 18, 2004Inventors: Michael D. Lesh, Thomas F. Kordis, Stuart D. Edwards
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Publication number: 20040022864Abstract: Devices and methods of delivering therapeutic agents to tissue are provided, which provide reduced outflow of therapeutic agents from an injection site. The methods include delivering one or more clot-promoting substances, such as platelets, fibrin and/or thrombin, to the injection site to entrap the therapeutic agent in the injection site. Devices include devices that are suitable for use in the provided methods.Type: ApplicationFiled: August 5, 2002Publication date: February 5, 2004Inventors: Toby Freyman, Maria Palasis, Wendy Naimark
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Patent number: 6685695Abstract: An intervertebral disc is treated by providing supplemental nutrition to increase viability and longevity. In the preferred embodiment, the invention uses one or more porous stents that function to irrigate the disc space. The stents provide channels for diffusion of fluids and nutrients from the vertebral endplates. The stents may extend across the vertebral endplates to facilitate the transfer of nutrients and oxygen from the vertebral bodies.Type: GrantFiled: May 10, 2002Date of Patent: February 3, 2004Inventor: Bret A. Ferree
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Publication number: 20040005295Abstract: A system delivers fibroblasts to a region of cardiac tissue at a location associated with a cardiac arrhythmia in a patient to form a conduction block in the region. A cardiac delivery system is coupled to a source the fibroblasts and delivers the fibroblasts to the location to form a conduction block. Substantial cardiac ablation is thus avoided. A contact member is shaped to correspond with a patterned region of tissue for delivering the fibroblasts along the pattern, such as linear, curvilinear, or circumferential patterns as required for treating particular arrhythmias. A pulmonary vein isolation assembly has an expandable or loop-shaped member cooperating with a needle array that delivers the fibroblast cells into a circumferential region of tissue engaged by the expandable member where a pulmonary vein extends from an atrium. Methods include providing the fibroblast cells as autologous cells in an injectable preparation.Type: ApplicationFiled: May 7, 2003Publication date: January 8, 2004Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, RHYTHM THERAPEUTICS CORPORATIONInventors: Randall J. Lee, Mark J. Maciejewski
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Publication number: 20030229318Abstract: A device for bile duct access and targeted delivery of fluid to the liver and pancreas and methods of use are described. The device allows improved delivery of fluid without causing damage the bile duct or surrounding tissues.Type: ApplicationFiled: June 6, 2003Publication date: December 11, 2003Inventor: Vladimir Subbotin
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Patent number: 6659995Abstract: In a method for autologous myocardial implantation treatment, a donor area of a patient containing healthy skeletal muscle is located. Myocyte micro granules are retrieved from the donor area using a retrieval device and either directly implanted into an implantation area of the patient's myocardium, or they are transferred to an implantation device and then implanted. No intervening cell culturing is performed between myocyte micro granule retrieval and implantation. A retrieval device that may be used to retrieve the myocyte micro granules from the donor area includes one or more extraction probes each having a distal tip adapted to be inserted into the skeletal muscle of the donor area. The retrieval device further includes a retrieval system that causes each distal tip to withdraw a myocyte micro granule upon removal thereof from the donor area.Type: GrantFiled: November 17, 2000Date of Patent: December 9, 2003Inventor: Syde A. Taheri
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Publication number: 20030215459Abstract: Methods, systems, and devices for promoting ultrasound-mediated gene transfection in vivo are disclosed. The methods and devices of the invention administer a gene formulation to the subject; and apply ultrasound energy to the subject, such that cell transfection is promoted. The ultrasound energy can be provided by an external source or an ultrasound source disposed inside the subject's body. For example, the source of ultrasound energy can be disposed on a catheter. The compositions suitable for ultrasound-mediated transfection can include genes (and plasmids containing such genes) in a pharmaceutically acceptable carrier and/or liposomes suitable for injection into a target site, aswell as implantable degradable matrix carriers.Type: ApplicationFiled: February 25, 2003Publication date: November 20, 2003Inventors: Anthony Atala, Marcelle Machluf
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Publication number: 20030180264Abstract: A method and device for delivery of a tissue to an organism uses a catheter or stent to deliver organized tissue to an anatomic site. Organized tissue may, in certain preferred embodiments, be grown in vitro in a catheter or stent, or in vitro independent of the catheter or stent, and then transferred to the catheter or stent. The organized tissue is transported to a desired anatomic site in vivo via catheter or stent. The organized tissue may be retrieved from the anatomic site to terminate treatment.Type: ApplicationFiled: February 28, 2003Publication date: September 25, 2003Applicant: Cell Based Delivery Inc.Inventors: Herman H. Vandenburgh, Robert F. Valentini
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Patent number: 6623472Abstract: A method for inducing therapeutically-effective protein includes selecting a syringe having inner structures coated with an inductor, disposing a therapeutically-effective protein therein with a body fluid and incubating the syringe and its contents. The inductor can be coated onto the interior of the syringe itself or can be placed on other structures and inserted into the interior of the syringe. A variety of inductors and body fluids may be used. Anticoagulants may also be used.Type: GrantFiled: July 6, 2000Date of Patent: September 23, 2003Assignee: Orthogen Gentechnologic. GmbHInventors: Julio Reincke, Hans Meijer, Peter Wehling
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Patent number: 6610044Abstract: A method is disclosed for enhanced vaccination and genetic vaccination of mammals. The vaccination is accomplished by delivering molecules such as proteins and nucleic acids into skeletal muscle and other cells residing in the skeletal muscle in vivo. The protein or nucleic acid is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the pharmaceutical drug or nucleic acid to enter the cell. The efficiency of transfer permits robust immune responses using DNA vaccines and produces sufficient secreted proteins for systemic biological activity to be observed.Type: GrantFiled: May 7, 2002Date of Patent: August 26, 2003Assignee: Inovio ASInventor: Iacob Mathiesen
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Patent number: 6599274Abstract: A cell delivery catheter having one of more apearutres is used to positon and deliver cells to an implant site in a patient.Type: GrantFiled: May 19, 2000Date of Patent: July 29, 2003Inventors: John Kucharczyk, George T. Gillies, William C. Broaddus, Helen L. Fillmore
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Patent number: 6595979Abstract: Methods for aspiration and filtering of a bodily fluid containing undesired components are provided and for treatment of the bodily fluids in a sterile environment in preparation for reinjection of treated aspirate into a donor subject. The invention methods are particularly designed to facilitate transfection of aspirated cells with angiogenesis promoting molecules without danger to the technician or the donor prior to reinjection of the treated cells, either percutaneously or via a surgical opening via a catheter or injection needle. A pressure actuator attached to the sterile container is used to express treated fluids in precisely controlled volumes. The invention methods include delivery of treated fluids using a hand-held device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.Type: GrantFiled: October 23, 2001Date of Patent: July 22, 2003Assignee: Myocardial Therapeutics, Inc.Inventors: Stephen Epstein, Shmuel Fuchs, Ran Kornowski
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Patent number: 6585972Abstract: A process for inhibiting vascular proliferation introduces a composition into the eye inducing posterior vitreous detachment. The composition includes a combination of plasminogen, a collagen crosslinking agent and at least one plasminogen activator selected from the group consisting of urokinase, streptokinase, tissue plasminogen activator, chondroitinase, pro-urokinase, retavase, metaloproteinase, and thermolysin. The composition is introduced into the vitreous in an amount effective to induce crosslinking of the vitreous and to induce substantially complete or partial posterior vitreous detachment from the retina without causing inflammation of the retina. In one embodiment, a gaseous material is introduced into the vitreous before or simultaneously with the composition to compress the vitreous against the retina while the composition induces the posterior vitreous detachment.Type: GrantFiled: October 18, 2001Date of Patent: July 1, 2003Inventor: Gholam A. Peyman
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Publication number: 20030109849Abstract: An apparatus delivers an agent to a treatment region, the apparatus having an outer cannula or lumen that has an internal surface and an external surface, the external surface being substantially smooth to penetrate tissue whereas the distal end is tapered; an inner cannula, or lumen coaxial to the outer cannula, providing a common fluid path (that is the same fluid passes through both the inner cannula and outer cannula) at the distal end with the inner surface of the outer cannula; a source of fluid to be passed through the common fluid path, the source of fluid comprising at least a reservoir of nutrients and/or gases for maintaining cells contained in a lumen coaxial and internal to the inner cannula; a semipermeable membrane comprises the surface of the lumen, thus allowing controlled material transport across the lumen surface; a source of cells or other biologically active material mass flow connected to the proximal lumen so that the cells or other biologically active material can exit the distal portType: ApplicationFiled: December 10, 2001Publication date: June 12, 2003Applicant: The Regents of the Univ. of MNInventors: Bruce E. Hammer, Mark J. Conroy
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Publication number: 20030100885Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.Type: ApplicationFiled: December 28, 2001Publication date: May 29, 2003Inventors: Ronald J. Pettis, Noel G. Harvey, Paul G. Alchas, James A. Down
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Publication number: 20030100889Abstract: The invention relates to a method for delivering a gene of interest to a vascular tissue comprising the following steps: (1) inserting into said vascular tissue a catheter in fluid communication with an inflatable balloon which is formed from a microporous membrane; and (2) delivering to said vascular tissue through the catheter a solution containing a vector comprising a gene of interest. This method can be used for the treatment of cardiovascular diseases, including hyperproliferative vascular disorders (such as restenosis), ischemic diseases (such as peripheral artery or coronary artery diseases), and atherosclerosis.Type: ApplicationFiled: July 3, 2002Publication date: May 29, 2003Inventors: Nicolas Duverger, Didier Branellec, Nathalle Aubailly, Glenda Bilder, Jeffrey Bostwick
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Patent number: 6569149Abstract: A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.Type: GrantFiled: June 21, 2002Date of Patent: May 27, 2003Assignees: Genetronics, Inc., The University of South Florida Research Foundation, Inc.Inventors: S. B. Dev, Gunter A. Hofmann, Richard A. Gilbert, Richard Heller, Mark J. Jaroszeski
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Publication number: 20030097118Abstract: The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to enhance production of collagen and thereby combat some of the effects of aging and oxy-radical damage on skin. Sufficient electric pulses applied to a region of skin surface temporarily create new pathways through the lipid skin barrier, thereby delivering an L-ascorbic acid-containing composition through the lipid skin barrier and enhancing production of collagen in the region of the skin so treated. A handheld electrical pulser apparatus, optionally table-top adaptable, and methods of use for cosmetic treatment of degenerative skin conditions are provided by the invention.Type: ApplicationFiled: September 27, 2001Publication date: May 22, 2003Applicant: GENETRONICS, INC.Inventors: Lei Zhang, Gunter A. Hofmann
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Patent number: 6558351Abstract: A closed loop infusion system controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The sensor signal is used to generate a controller input. The controller uses the controller input to generate commands to operate the delivery system. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. Preferably, the sensor system monitors the glucose concentration in the body of the user, and the liquid infused by the delivery system into the body of the user includes insulin. The sensor system uses the sensor signal to generate a message that is sent to the delivery system. The message includes the information used to generate the controller input.Type: GrantFiled: June 1, 2000Date of Patent: May 6, 2003Assignee: Medtronic MiniMed, Inc.Inventors: Garry M. Steil, Kerstin Rebrin, Paul V. Goode, Jr., John J. Mastrototaro, Richard E. Purvis, William P. Van Antwerp, John J. Shin, Cary D. Talbot
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Publication number: 20030073908Abstract: A method and apparatus for delivery of genes, enzymes and biological agents to tissue cells, including a method and apparatus wherein treatment fluids, including genes, enzymes and biological agents, are injected into a target area of a body providing selective attachment to the specific target cells without affecting normal tissue cells. The method is used to treat prostate cancer, breast cancer, uterine cancer, bladder cancer, stomach, lung, colon, and brain cancer, etc. A hollow core needle is inserted into a body, the needle being visually guided by a selected imaging technique. A first embodiment utilizes an endoscopic instrument, wherein a probe is inserted into the body, guided by the endoscope to the vicinity of the target area. The hollow core needle is guided to the vicinity by a channel through the probe. A needle adjustment apparatus is used to extend or retract the needle and adjust needle tip orientation toward a target area.Type: ApplicationFiled: October 4, 2002Publication date: April 17, 2003Applicant: 2000 InjecTx, Inc.Inventor: Ashvin H. Desai
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Publication number: 20030055400Abstract: A method of interventional surgery is described. The method may include inserting an actuator within a body of a vascularized organism and positioning the actuator adjacent a target region within a vessel of the body. The actuator is operated to cause a needle thereof to move in a substantially perpendicular direction relative to a wall of the vessel to produce an opening therein. A therapeutic or diagnostic agent may be delivered by the needle to the target region via the opening in the vessel wall.Type: ApplicationFiled: September 20, 2001Publication date: March 20, 2003Inventors: Kirk Patrick Seward, Albert P. Pisano
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Patent number: 6530912Abstract: An apparatus for connecting a compatibility liner with a source of perishable therapeutic is provided. In one exemplary system for connecting a reservoir of perishable therapeutic with a lumen, a hollow hub having a first end and a second end is provided. The first end of the hollow hub, which contains a bond port, is in fluid communication with the second end. The second end of the hollow hub may contain a docking groove that is sized to couple a reservoir to it. The system also includes an inner hypo-tube having a proximal tip and an inner lumen. This inner lumen is lined with a therapeutic compatible lining and is in fluid communication with the second end of the hub through the proximal tip of the inner hypo-tube. The inner lining and the proximal tip in this system are configured to shield therapeutic ejected from the reservoir from contacting materials that can diminish the integrity of the therapeutic.Type: GrantFiled: January 12, 2001Date of Patent: March 11, 2003Assignee: SciMed Life Systems, Inc.Inventors: Justin M. Crank, Timothy A. Ostroot
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Patent number: 6527759Abstract: A kit and method for causing tissue death within a tissue site is disclosed. The kit includes a media with a light activated drug activatable upon exposure to a particular level of ultrasound energy. The kit also includes a catheter with a lumen coupled with a media delivery port through which the light activated drug can be locally delivered to the tissue site. The ultrasound transducer is configured to transmit the level of ultrasound energy which activates the light activated drug with sufficient power that the ultrasound energy can penetrate the tissue site.Type: GrantFiled: July 20, 2000Date of Patent: March 4, 2003Assignee: Ekos CorporationInventors: Katsuro Tachibana, Shunro Tachibana, James R. Anderson, Gary Lichttenegger
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Patent number: 6527760Abstract: Out-patient knee lavage is performed by use of a kit comprising: A. Means for preparing the knee joint for lavage; B. An optional surgical drape; C. A first needle and a first syringe containing a first local anesthesia; D. A second needle and second syringe containing a second local anesthesia; and E. A third syringe adapted to fitting the second needle, the third syringe containing a lavage fluid. The knee lavage is performed by: 1. Cleansing the knee joint and, preferably, covering it with a surgical drape; 2. Applying the first local anesthesia superficially to the joint to create a wheat; 3. Injecting through the wheal the second local anesthesia into the knee joint; and 4. Performing the lavage on the knee joint without removing the second needle from the knee joint.Type: GrantFiled: September 25, 2000Date of Patent: March 4, 2003Inventor: Vijay B. Vad
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Patent number: 6519492Abstract: This invention is directed to a novel method for direct in vivo electrotransfection of a plurality of cells of a target tissue. In the method, the target is perfused with a transfection solution. An exterior electrode is positioned so as to surround at least a portion of the target tissue. One or more interior electrodes are placed within the target tissue. The perfusion and the application of the interior and exterior electrodes may be performed in any particular order. After the perfusion and the positioning of the electrodes, both interior and exterior, an electric waveform is applied through the exterior electrode and the interior electrode to transfect the cells in the target tissue.Type: GrantFiled: September 13, 2001Date of Patent: February 11, 2003Assignee: Children's Medical Center CorporationInventors: James J. Yoo, Anthony Atala
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Publication number: 20020198512Abstract: Electroporation of cells in target tissues is performed using microneedles having integral electrode structures. In a first embodiment, a pair of electrode structures are disposed on opposite sides of a substance delivery opening on a needle or other tissue-penetrating shaft. In a second embodiment, a first electrode structure is disposed on the needle and a second electrode structure is disposed on an attached base. The electrode structures are spaced closely together and relatively low voltages are applied to achieve electroporation-enhanced substance delivery.Type: ApplicationFiled: June 10, 2002Publication date: December 26, 2002Applicant: ENDOBIONICS, INC.Inventor: Kirk Patrick Seward
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Publication number: 20020138066Abstract: A container for pathogen inactivating and storing blood or blood components, which includes multiple sub-compartments fluidly interconnected by an openable closure assembly. Each sub-compartment may contain a component necessary for pathogen inactivation or blood storage. Upon opening the openable closure assembly, the sub-compartments become one compartment and the components contained within each sub-compartment may be mixed together to form a combined solution for pathogen inactivation and/or storage of blood or blood components.Type: ApplicationFiled: March 21, 2002Publication date: September 26, 2002Applicant: Gambro, Inc.Inventors: Keith Manica, Dennis J. Hlavinka, Jeannie M. Woods
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Publication number: 20020133137Abstract: A device for in vivo electroporation therapy comprising an electrode applicator with at least two pairs of electrodes arranged relative to one another to form an array and a power supply. The device is used to generate an electric field in a biological sample and effect introduction of selected molecules into cells of the sample.Type: ApplicationFiled: July 5, 2001Publication date: September 19, 2002Inventor: Gunter A. Hofmann
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Patent number: RE39086Abstract: This invention provides the use of Botulinum toxin (BTX) to cause paralysis of a depressor anguli oris (DAO) musculature in a patient to alleviate downturn at corners of the patient's mouth.Type: GrantFiled: March 17, 2004Date of Patent: May 2, 2006Assignee: Allergan, Inc.Inventors: Jean D. A. Carruthers, Alastair Carruthers
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Patent number: RE39533Abstract: The A fertilization process comprises includes the following steps: a) a container (15) which can be introduced into, and lodged in, the uterine cavity of the mammal is provided; b) the container (15) is filled with a culture medium, at least one ovocyte of the mammal, and spermatozoa; c) the filled container (15) is inserted into the uterine cavity; d) the container (15) is left for a given length of time to allow fertilization of the ovocyte(s) to take place; e) the contents of the container (15) are released into the uterine cavity. The container may be made from a tube of biodegradable or non-biodegradable material. In the latter case, it is associated with a stiffening device. A biodegradable container (15) filled with gametes and a culture medium is placed in the uterine cavity using an implantation device (20) which is then withdrawn from the mammal's genital tract.Type: GrantFiled: May 2, 1988Date of Patent: March 27, 2007Assignee: Biofertec Ltd.Inventor: Claude Ranoux