Treating Material Introduced Directly Into Liquid Stream Path Patents (Class 604/83)
  • Patent number: 7914484
    Abstract: An applicator to be used with first and second liquid-containing syringes comprises an applicator main body for receiving the syringes, a gas flow path adapted to be connected to a gas supply for supplying a gas, a nozzle through which is discharged the gas and the liquids in the syringes, an operation part adapted to be pressed to operate pushers of the syringes, and an opening and closing mechanism in the operation part for shutting off/opening the gas flow path. The opening and closing mechanism is operable to open the gas flow path in synchronization with the pressing operation by the operation part.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: March 29, 2011
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Kenji Yokoyama
  • Patent number: 7875001
    Abstract: A nasal spray apparatus for simultaneously administrating metered amounts of multiple medicaments includes chambers for separately storing incompatible medicaments, such as an antihistamine and a steroid. Reciprocal piston pumps allow the medications to be sprayed into the user's nasal cavity. Two pumps can be used to separately transfer the medicaments to a receptacle where they can be initially mixed just prior to administration. A small volume receptacle is used to reduce the amount of mixture remaining after each stroke of the nasal spray apparatus. A check valve can be associated with each pump to further reduce medicament mixtures from cross contamination within storage chamber preparations. Collapsible components, including collapsible storage chambers or balloon capacitors can be employed to compensate for vacuums and back pressures as the medicaments are pumped to a spray nozzle.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: January 25, 2011
    Inventor: Americo Michael Minotti
  • Publication number: 20100305548
    Abstract: A body portion of the apparatus comprises an interior cavity and a plurality of fluid lumens extending from the cavity to a periphery of the body portion. The apparatus further comprises a first fluid port in fluid communication with a first one of the fluid lumens. The first fluid port is configured to receive a syringe for injecting a liquid diluent and withdrawing a reconstituted liquid medicament. The apparatus further comprises a second fluid port in fluid communication with a second one of the fluid lumens. The second fluid port is configured to receive a medicament vial. The apparatus further comprises a third fluid port at an end of a third one of the fluid lumens for expelling the reconstituted liquid medicament. The apparatus further comprises a stopcock received within the body portion interior cavity and configured to regulate fluid communication between the fluid lumens.
    Type: Application
    Filed: May 26, 2009
    Publication date: December 2, 2010
    Inventor: Timothy Y. Kraushaar
  • Patent number: 7780621
    Abstract: A blood chamber for an extracorporeal blood circuit comprises a blood inlet port (2), a blood containment chamber (3), a first conduit (8) which connects the blood inlet port (2) with the blood containment chamber (3) and which has an end tract (8a) that terminates in the blood containment chamber (3) with a horizontal inlet component. The first conduit (8) comprises a pre-terminal tract (8b) which precedes the end tract (8a) and which has at least a second horizontal component which is directed in an opposite direction to the horizontal inlet component. The blood chamber is used in an arterial line of a dialysis set for guaranteeing a regular and gentle blood flow.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: August 24, 2010
    Assignee: Gambro Lundia AB
    Inventors: Robert Neri, Andrea Paltrinieri
  • Patent number: 7771387
    Abstract: Devices and methods are provided for delivering fluid components of an embolic mass into a body cavity. A connector, which includes a receiving element, a first port, and a second port, is provided for securing an outer tubular element and an inner tubular element such that the outer tubular element coaxially surrounds the inner tubular element. The first port is in fluid communication with the lumen of the outer tubular element when the outer tubular element is secured to the receiving element; and the second port is in fluid communication with the lumen of the inner tubular element when the inner tubular element is secured to the connector. First and second fluid components of an embolic composition are delivered into the first and second ports of the connector and through the lumens of the outer and inner tubular elements for occlusion of the body cavity.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: August 10, 2010
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Stephen Christopher Porter
  • Publication number: 20100106086
    Abstract: There are provided an intermediate slide valve as well as a plunger slide valve equipped in a syringe in direct contact with injection liquids and a syringe equipped with such slide valves, the injection liquids nor valves being not affected with each other. The intermediate slide valve 10 equipped in the syringe 10 comprises an approximately cylindrical first elastic body 13 and an approximately cylindrical second elastic body 14 which is jointed with one bottom surface 13c of the first elastic body 13, the other bottom surface 13a of the first elastic body 13 and a side surface portion continued therefrom being laminated with a synthetic resin film 15 and the other bottom surface 14a of the second elastic body 14 and a side surface portion continued therefrom be laminated with a synthetic resin film 16.
    Type: Application
    Filed: June 20, 2008
    Publication date: April 29, 2010
    Applicant: DAIKYO SEIKO, LTD.
    Inventors: Masamichi Sudo, Nobuo Sudo
  • Publication number: 20100106085
    Abstract: The present invention relates to a container (1) comprising:—a body (2) a pusher (5) movable with respect to said body (2) between an “initial position” and an “end-of-use position”—a locker (7) located on said pusher (5) and forming an abutment so as to be able to abut against said body (2) between said “initial position” and “end-of-use position”,—locking means (9, 9h, 8, 5, 4a, 11, 12, 15, 29, 29a, 30a) capable of, temporarily, lock said locker (7) on said pusher (5), in the proximal direction relative to said pusher (5), an as to define a “locker locking position” and, when said pusher (5) abuts against said body (2) via said locker (7), define a “pusher locking position”,—unlocking means (9, 9a, 10, 29, 31, 13, 16, 17, 31) designed so that their triggering causes the release of said locking means so as to allow i) said locker (7) to be displaced proximally relative to said pusher (5) and ii) said pusher (5) to be moved past said “pusher locking position” toward said “end-of-use position”, which container
    Type: Application
    Filed: September 12, 2007
    Publication date: April 29, 2010
    Applicant: BECTON DICKINSON FRANCE S.A.S.
    Inventor: Frederic Perot
  • Publication number: 20100063440
    Abstract: A liquid mixing and injecting device is provided which includes an upper branch tube, a chamber part and a rubber plug including a slit formed through the body of the rubber plug. A lid member is attached to an open end of the upper branch tube. The lid includes an opening part and a generally cylindrical member. The upper branch tube is occluded by the rubber plug. A male luer part of a syringe can be inserted into the slit to access the chamber part. A rubber plug receiving part is provided for controlling the shape of the lower end part of the rubber plug body when it is deformed to avoid forming a gap where air can accumulate within the flow path. The rubber plug is fixed by fixing an upper fixing piece of the rubber plug to the generally cylindrical member and by fixing a lower fixing piece between the opening part and the generally cylindrical member.
    Type: Application
    Filed: January 25, 2008
    Publication date: March 11, 2010
    Inventors: Ichiro Kitani, Shigeaki Funamura, Norifumi Fujiwara
  • Publication number: 20100056995
    Abstract: A dispensing device for dispensing first and second medicaments to a patient that is made up of first and second stand-alone, interconnectable assemblies. The first of these assemblies comprises a fluid reservoir assembly that houses a fluid reservoir defining component while the second assembly comprises a fluid delivery and control assembly that includes an adding assembly for controllably dispensing the second medicament to the patient, a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first assembly toward the patient via a plurality of fluid flow control passageways.
    Type: Application
    Filed: June 3, 2009
    Publication date: March 4, 2010
    Inventor: Marshall S. Kriesel
  • Publication number: 20090318893
    Abstract: An apparatus for use in reconstituting and administering a predetermined medication into a patient's primary IV includes an IV bag containing a first predetermined amount of a predetermined fluid; a disposable pressure for at least partially enclosing such IV bag; means engageable with such pressure bag for applying pressure to such IV bag as directed by a user; a secondary intravenous tubing having a clamp member for permitting and terminating flow of fluids there through operably connectable to such IV bag at a first predetermined location; a plurality of vented cap mini spikes each operably connectable at a first end thereof to at least one of such secondary intravenous tubing, a syringe, and a combination thereof; and a syringe for drawing such reconstituted medicine into an interior portion therein and there after dispelling such predetermined amount of such reconstituted medicine into such patient's primary IV.
    Type: Application
    Filed: June 23, 2009
    Publication date: December 24, 2009
    Inventor: MARY L. ENGLISH
  • Publication number: 20090275888
    Abstract: A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as, antibiotics, analgesics, and like medicinal agents from the device reservoir which is provided in the form of a novel bellows-type assembly. The fluid dispenser includes a unique stored energy mechanism which takes the form of a constant force spring member of novel design that provides the force necessary to continuously and substantially uniformly expel fluid from the device reservoir. The device also includes novel adjustable flow rate control assembly that is disposed intermediate the fluid reservoir outlet and the outlet port of the device for precisely controlling the rate of fluid flow from the outlet port toward the patient.
    Type: Application
    Filed: June 3, 2009
    Publication date: November 5, 2009
    Inventors: Marshall S. Kriesel, Joshua W. Kriesel, Thomas N. Thompson
  • Publication number: 20090259170
    Abstract: A gas sterilizable delivery system for a two-part polymer system is provided. The delivery system includes at least two syringe barrels, each barrel being sealed with a gas permeable plunger seal allowing permeation of a sterilant gas to permeate through the plunger seal allowing the entire assembly to be gas sterilized.
    Type: Application
    Filed: April 11, 2008
    Publication date: October 15, 2009
    Applicant: Applied Silicone Corporation
    Inventor: R. Alastair Winn
  • Publication number: 20090254031
    Abstract: A method of combining a drug in a first container and a liquid in a second container includes placing the first container and the second container in fluid communication with a housing, combining the liquid and the drug in the first container, transferring the liquid and the drug from the first container to the housing, and transferring the liquid and the drug from the housing to a third container.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 8, 2009
    Inventor: Freddie Eng Hwee Lee
  • Publication number: 20090204066
    Abstract: A drug mixing and expelling device (1) for mixing a drug with a liquid, thereby forming a reconstituted liquid drug. The device comprises a reservoir (2) containing a liquid, a vial (4) containing a drug, a vial, means (5) for establishing a fluid connection between the reservoir and a vial positioned in the vial adapter (3), means (7, 8) for forcing the liquid from the reservoir to a vial, and means (9) for activating said forcing means during establishment of the fluid connection between the reservoir and the vial. The forcing of liquid into the vial provides a pressure therein, which can be used for infusion of the reconstituted drug directly from the vial. The device also comprises a suction unit (13) for aspiration.
    Type: Application
    Filed: June 7, 2007
    Publication date: August 13, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Bo Radmer, Morten Revsgaard Fredriksen
  • Publication number: 20090198217
    Abstract: Two convenience kits are disclosed. A first convenience kit provides a basic configuration for use in measuring, filling and dispensing medication and flush solutions to IV sets and patient catheters through needleless connectors while improving safety and efficacy by requiring fewer post-sterilization makes and breaks compared to conventional filling and dispensing methods. A second convenience kit which, being a companion to the first convenience kit, provides safety in access to a vial. Methods of use of both kits improve flush compliance by facilitating dispensing of flush solutions and decreases likelihood of infections by providing for flushing of connecting sites while reducing numbers of breaks required for associated medical procedures.
    Type: Application
    Filed: January 6, 2009
    Publication date: August 6, 2009
    Inventors: Gale H. Thorne, JR., Gale H. Thorne
  • Publication number: 20090171191
    Abstract: Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.
    Type: Application
    Filed: December 22, 2008
    Publication date: July 2, 2009
    Applicant: Carticept Medical, Inc.
    Inventors: Timothy Patrick, Richard Knostman, Michael Axelrod, Carribeth Ramey
  • Publication number: 20090171193
    Abstract: Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.
    Type: Application
    Filed: December 22, 2008
    Publication date: July 2, 2009
    Applicant: Carticept Medical, Inc.
    Inventors: Timothy Patrick, Richard Knostman, Michael Axelrod, Carribeth Ramey
  • Publication number: 20090163860
    Abstract: Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.
    Type: Application
    Filed: December 19, 2008
    Publication date: June 25, 2009
    Applicant: Carticept Medical Inc.
    Inventors: Timothy Patrick, Richard Knostman, Michael Axelrod, Carribeth Ramey
  • Publication number: 20090131864
    Abstract: The invention relates to a method and a device for lyophilizing, reconstituting and administering a reconstituted substance. The device has an elongate housing comprising a dispensing-side front housing end and a housing end lying opposite it. A first chamber with a lyophilizate contained in it is disposed in the housing in the region of the front housing end, which is tightly sealed at its end facing the front housing end by means of a removable closure and in the direction of the rear housing end by means of a plunger. A second chamber is provided or formed in the housing in the region of the rear housing end, which is connected by means of at least one opening to the ambient atmosphere. This opening is closed by a membrane which is permeable to gas but not to bacteria.
    Type: Application
    Filed: October 25, 2005
    Publication date: May 21, 2009
    Inventor: Ewald Pickhard
  • Publication number: 20090043282
    Abstract: This description relates to drug delivery devices (100), as well as related components, systems and methods.
    Type: Application
    Filed: April 26, 2006
    Publication date: February 12, 2009
    Applicant: WYETH
    Inventors: Martin Hughes, Darren Seymour, Colin Turner, Paul Harmer, Yannick Hourmand
  • Publication number: 20090036764
    Abstract: Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 5, 2009
    Applicant: OptiScan Biomedical Corporation
    Inventors: Gil Rivas, Michael Butler, Jeffrey T. Chiou, Eugene Lim
  • Publication number: 20090005731
    Abstract: An applicator to be used with first and second liquid-containing syringes comprises an applicator main body for receiving the syringes, a gas flow path adapted to be connected to a gas supply for supplying a gas, a nozzle through which is discharged the gas and the liquids in the syringes, an operation part adapted to be pressed to operate pushers of the syringes, and an opening and closing mechanism in the operation part for shutting off/opening the gas flow path. The opening and closing mechanism is operable to open the gas flow path in synchronization with the pressing operation by the operation part.
    Type: Application
    Filed: August 28, 2008
    Publication date: January 1, 2009
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventor: Kenji Yokoyama
  • Patent number: 7425207
    Abstract: A vial for dispensing a liquid into a syringe is described which comprises a body section for holding the liquid, the body section having a top and a bottom; a port having a removable seal, where the port is adapted for a syringe connection and where the port is interconnected with the body section at a point near the top of the body section by a passageway which for at least a portion of its length extends above the level of the liquid in the body section when the vial is inverted, thereby preventing leakage of the liquid from the body section when the seal of the port is removed. A method of making the vial is also described.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: September 16, 2008
    Assignee: Holopack International Corp.
    Inventors: Shawn W. Miller, David Rocheleau, Mohammad R. Sadeghi, Walter Zahn, Bernd Hansen
  • Patent number: 7302960
    Abstract: A valve (10) comprises a housing (12) with a valve element (14) which normally fluidicly couples a low pressure operating device, such as a transducer (30) and tubing (34) to be coupled to a patient (36) along a first flow path (42) including a flexible control wall (58) which normally interrupts a second flow path (72) between a high pressure generating source such as an injector syringe (32) and the tubing (34), but which flexes, in response to high pressure excursions from the syringe (32) to allow the second flow path (72) to open as it flexes into the first flow path (42) to thereby restrict same thus providing protection to the transducer (30) during the high pressure excursion from the syringe (32).
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: December 4, 2007
    Assignee: Smiths Medical ASD, Inc.
    Inventor: Charles R. Patzer
  • Patent number: 7250619
    Abstract: The disclosure below relates to apparatus and methods for producing medicament using sub-optimal water sources. One embodiment of the disclosure is directed to an apparatus comprising a preliminary purification component, a disinfection component, a pharmaceutical grade water preparation (PGW) component, and a drug pack. Another disclosed embodiment relates to a method for producing a peritoneal dialysis solution, comprising, passing diluent through a preliminary purification component, passing diluent through a disinfection component, passing diluent through a PGW preparation component, passing diluent through a drug pack, and collecting solute produced by the drug pack.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: July 31, 2007
    Assignees: PrisMedical Corporation, Water Health International, Inc.
    Inventors: Michael A. Taylor, Mark L. Sizelove, Tralance O. Addy
  • Patent number: 7025744
    Abstract: A medical device has an interior for containment of fluids; an opening into the interior, an elastomeric wall comprising a fixedly placed, flexible barrier across the opening; and a retention wall positioned adjacent to a peripheral portion of the elastomeric wall. The retention wall defines a central opening and has a generally rigid retention zone surrounding the central opening, to engage and retain a connector tube which is advanced into the central opening to displace the elastomeric wall and to open a flow aperture through the elastomeric wall, for flow through the wall and connector tube. One of the retention zone and connector tube are made of a material of sufficient hardness that material of the other engaging member is deformed by engagement therewith, which increases the strength of retention between the retention wall and the connector tube.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: April 11, 2006
    Assignee: DSU Medical Corporation
    Inventors: David S. Utterberg, William J. Schnell, David Bell
  • Patent number: 6884232
    Abstract: A laparoscopic spray device for selectively applying a multiple component material dispensed from a multiple component material applicator to a surgical site in vivo is disclosed. The device comprises an interface member capable of engaging a multiple component applicator, a body having at least two lumens therein, and a detachable spray tip in fluid communication with the body. The detachable spray tip includes a mixing chamber having at least one flexible mixing member positioned therein which is capable of creating a turbulent flow within a mixing chamber. In addition, the at least one mixing member prevents a back flow of material from the mixing chamber to the at least two lumens. The present invention is particularly useful in remotely applying multiple component tissue adhesives to an internal incision.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: April 26, 2005
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Adam Hagmann, Richard Spero, Atif M. Yardimci
  • Patent number: 6805685
    Abstract: An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: October 19, 2004
    Assignee: PrisMedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6800072
    Abstract: A contrast dispensing system (10) reduces cost by directly connecting a check valve (210) to and between the reservoir inlet port (220) and the mating luer connector (204) of a disposable set (200). A contrast dispensing system (10) includes as part of the reservoir (212) an integrally molded cap (280) having the inlet port (200) and a lateral pipe (300) to confine contrast media (14) therein and disperse it at separate locations (334, 336) within the chamber (260) of reservoir (212). The reservoir (212) may have a vent port (284) with a flip cap (294) for selectively opening or closing same.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: October 5, 2004
    Assignee: Medex, Inc.
    Inventor: Charles R. Patzer
  • Patent number: 6733472
    Abstract: Multipurpose fluid applicators and applicator tips, particularly suitable for surgical purposes, are disclosed. The applicators and applicator tips are specifically designed for dispensing various combinations of sterile pressurized gas, suction, irrigation and sealant agents, including a mixed liquid sealant agent. Preferred embodiments employ a dual-acting valve selectively to control the flow of gas or suction which valve is capable of simultaneously varying flow from a source and the venting of that flow to atmosphere.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: May 11, 2004
    Assignee: Baxter International Inc.
    Inventors: Gordon Howard Epstein, Mitchell E. Levinson, Richard K. Spero
  • Patent number: 6712786
    Abstract: A single-use preassembled medical device for administering at least two drugs in preset proportions to patients, comprising at least one pair of independent injectors and at least one pair of piercing couplings for corresponding bottles containing the drugs which are reciprocally connected by corresponding tubes which lead into a single tube for infusion to a patient; at least one of the piercing couplings is of a conventional type and the second one is of a dedicated type, forming a conveniently provided small cup-shaped receptacle for the precision insertion of the neck of a bottle of a preset drug whose dimensions are likewise correspondingly smaller than those of a normal bottle.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: March 30, 2004
    Assignee: Sidam di Azzolini Graziano E C. S.a.s.
    Inventor: Graziano Azzolini
  • Publication number: 20040010242
    Abstract: The present invention presents a novel ampoule filtration system, and novel methods and devices for using the system to deliver multi-doses of a sterile solution of a therapeutic agent to a subject. The ampoule filtration system includes a sterile filter cartridge attached to the mouth of an ampoule, such that liquid dispensed from the ampoule is drawn through the cartridge, and a means for sealingly engaging the filtration system to a delivery device.
    Type: Application
    Filed: April 10, 2003
    Publication date: January 15, 2004
    Inventors: Robert H. Heyes, Peter N. Carpenter, Remo Ponta
  • Patent number: 6676632
    Abstract: An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: January 13, 2004
    Assignee: PrisMedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6638258
    Abstract: An automatic manifold for a catheter assembly. Valve means automatically open and close flow between a liquid supply port for connection to injection means and a liquid delivery port for communication with the catheter assembly. A pressure sensor is integrated into the manifold. The manifold also includes a quick-disconnect coupling mechanism for a liquid supply port.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: October 28, 2003
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Robert S. Schwartz, David R. Holmes, David Berry, Donald G. Ellis
  • Patent number: 6620125
    Abstract: A method and a device for mixing at least two liquid components of different viscosities of a multi-component material, such as a tissue adhesive, during application thereof, are disclosed, the components being pressed out of separate containers, mixed, and applied by aid of an application part, e.g. a cannula, the less viscous component being directly pressed into the flow of at least one other, more viscous component.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 16, 2003
    Assignee: Baxter Aktiengesellschaft
    Inventor: Heinz Redl
  • Patent number: 6605066
    Abstract: A device for the formation and delivery of a mixture, notably a surgical adhesive, consisting of a receptacle adapted for easy handling by the surgeon, and including the means of receiving two syringe barrels containing the constituents of the mixture, the means of simultaneously expelling the contents, the means of maintaining the contents of syringe containing the first constituent, at a predetermined temperature setting which is higher than body temperature, and a mixer simultaneously receiving the contents of the two syringes, and the mixer also being used for cooling.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: August 12, 2003
    Assignee: Imedex Biomateriaux
    Inventors: Philippe Gravagna, Jean-Louis Tayot
  • Patent number: 6599264
    Abstract: A method and a needleless injection system for administering a medication. In order to simplify as far as possible the handling necessary for loading the injector with medication and thereby eliminate risks caused by a complex handling the method and system according to the invention provide loading of medication into a needleless injector device by means of a syringe prefilled with a medication, this loading step preferably including connecting the syringe to the injector device by means of a suitable coupling member or adapter and operating the syringe for transferring medication prefilled therein into the injector device. After this transfer the syringe and/or the coupling member or adapter are detached from the injector device, which is then ready to be operated for ejecting the loaded dosage of said medication from the injector device and thereby pass the selected dosage through the skin of an injection receiver.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: July 29, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Erni, Martin List
  • Patent number: 6595951
    Abstract: The present invention is directed to a closure system for an oral active agent delivery device. The device comprises an elongate tubular member having first and second ends. The closure system includes a deformable closure means adapted to allow delivery of the active agent upon deformation. The closure system prevents spillage and maintains the integrity of the dose within the device. In use, the closure system is deformed and separated from the second end of the tubular member, liquid is drawn up into the first end of the member, and the liquid and active agent are drawn out of the second end of the member and into the patient's mouth.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: July 22, 2003
    Assignee: Alza Corporation
    Inventors: Patrick S. -L. Wong, James Horvath, Radomir N. M. Vukadin, Joyce C. Anthony, Vincent J. Ferrari, Jeffrey W. Etter, Christopher M. G. Ohms
  • Patent number: 6520932
    Abstract: An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: February 18, 2003
    Assignee: Prismedical Corporation
    Inventor: Michael A. Taylor
  • Publication number: 20020183690
    Abstract: The syringe (10) for self-injecting an extemporaneous mixture comprises:
    Type: Application
    Filed: June 18, 2002
    Publication date: December 5, 2002
    Inventor: Yves Arnisolle
  • Patent number: 6428505
    Abstract: An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: August 6, 2002
    Assignee: PrisMedical Corporation
    Inventor: Michael A. Taylor
  • Patent number: 6371942
    Abstract: An automatic manifold for a catheter assembly. Valve means automatically open and close flow between a liquid supply port for connection to injection means and a liquid delivery port for communication with the catheter assembly. A pressure sensor is integrated into the manifold. The manifold also includes a quick-disconnect coupling mechanism for a liquid supply port.
    Type: Grant
    Filed: September 23, 1998
    Date of Patent: April 16, 2002
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Robert S. Schwartz, David R. Holmes, David Berry, Donald G. Ellis
  • Patent number: 6364861
    Abstract: An IV manifold includes a plurality of injection/aspiration ports and has an elongate configuration with a width greater than the diameter of the ports. A flow channel is formed between mating members of a housing and provided with a U-shaped configuration. Projections along the flow channel direct fluid flow into valve cavities associated with the ports to clear dead spots around the valve elements. A check valve included in the manifold tends to direct high pressures against the valve elements which respond by forming surface seals thereby avoiding deformation. An aspiration port can be formed with a second seal disposed on the side of the valve element opposite the first seal. Opening this second seal by negative pressure in the lumen of the port provides for the aspiration of fluids in the flow channel. Two-way aspiration can be provided by a valve having a cage with or without compressible characteristics to accommodate low tolerance fittings.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: April 2, 2002
    Assignee: Porex Medical Products, Inc.
    Inventors: Raymond P. Feith, Tim Truitt, Gary S. Werschmidt
  • Patent number: 6296621
    Abstract: The present invention provides a receptacle used in a passive drug delivery system. The receptacle includes first flow path for supplying along a fluid conduit a medical liquid, second flow path for introducing the medical liquid into a container containing a beneficial agent, third flow path for delivering a mixed solution containing the medical liquid and agent, and a guide valve for controlling the flow path by closing or opening the flow path.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: October 2, 2001
    Assignee: Baxter International Inc.
    Inventors: Kouichirou Masuda, Kazumasa Maeda, Haruki Kazama, Brian J. Gorman
  • Patent number: 6274090
    Abstract: A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: August 14, 2001
    Assignee: ThermoGenesis Corp.
    Inventors: Philip Henry Coelho, Phil Kingsley, Jim Brausch, James H. Godsey, Gail Rock
  • Patent number: 6182698
    Abstract: The valve assembly has inlet and outlet members with valve elements disposed between the two members. The valve is a resilient membrane having one or more through holes. When there is no pressure differential across the valve, the hole walls in the membrane collapse inwards closing off the valve against liquid flow. At or above a threshold pressure differential across the valve, the membrane is stretched which opens up the hole or holes to allow the passage of liquid.
    Type: Grant
    Filed: April 13, 1998
    Date of Patent: February 6, 2001
    Assignee: Societe des Produits Nestle SA
    Inventor: Swi Barak
  • Patent number: 6132396
    Abstract: A device and method for applying a fibrinogen-based tissue sealant to seamlessly connect human or animal tissues or organ parts, to seal wounds, stop bleeding and the like by mixing fibrin or fibrinogen with blood clot-promoting coagulation factors are disclosed. The device includes two cylindrical compartments for separately containing the separate fluid components of the sealant preparation, which are simultaneously displaced from the respective compartments by plungers commonly depressable with the same effective strokes. The plungers may be depressed directly or by a common mechanism (e.g., rack and pinion) for accurately controlling the rate of dispensing fluid. The cylindrical compartments are of the same or different cross-sectional area and are arranged either concentrically or side-by-side. The device further includes structure for merging the two fluid components within an outer sleeve housing an inner needle.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: October 17, 2000
    Assignee: PlasmaSeal LLC
    Inventors: Richard D. Antanavich, Randel Dorian
  • Patent number: 6083194
    Abstract: A medical connector is for use in transferring fluids to and from a patient. The connector has a primary conduit, which has an upstream branch in fluid communication with a primary source of fluid and a downstream branch in fluid communication with a patient. The connector also has a secondary conduit in fluid communication with said primary conduit. Additionally, the connector has a hollow, resilient valve positioned such that the primary fluid can flow through the valve when the valve is in a decompressed state. The valve has a tab extending into the secondary conduit such that a luer inserted in the secondary conduit compresses the tab, thereby preventing flow of the primary fluid through the connector while permitting both flow of fluid to the patient from the luer and flow of fluid from the patient to the luer.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: July 4, 2000
    Assignee: ICU Medical, Inc.
    Inventor: George A. Lopez
  • Patent number: 6036669
    Abstract: An apparatus for modifying a liquid enteral nutritional product. The apparatus includes a feeding set having an inlet and an outlet. The inlet is constructed for fluid connection to a supply container. The feeding set defines an interior space. The apparatus further includes a canister disposed in the interior space defined by the feeding set. The canister includes a wall portion that defines an aperture therethrough. The canister is constructed to receive one or more beneficial agents in an interior chamber defined therein. At least one beneficial agent disposed in the interior chamber defined by the canister.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: March 14, 2000
    Assignee: Abbott Laboratories
    Inventors: Rhonda L. Cole, Ronita K. Geckle, John J. Kropczynski, Jr., Terrence B. Mazer, Joseph E. Walton, Daniel Zevchik
  • Patent number: 5984889
    Abstract: A phacoemulsification handpiece for ophthalmic surgical procedures includes a needle having a tip and connected to a source of ultrasonic energy, for cutting and/or fragmenting eye tissue along with a conduit for introducing irrigation fluid proximate the needle tip. The handpiece also includes separate structure for introducing a viscous fluid, such as a viscoelastic material, proximate the needle tip as well as bore through the needle and handpiece for aspirating irrigation fluid, viscoelastic material end cut and/or fragmented eye tissue. An accumulator, connected to the housing is provided for containing a supply of viscous fluid. A diaphragm assembly and a manual valve are provided for delivering viscous material to the needle tip.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: November 16, 1999
    Assignee: Allergan Sales, Inc.
    Inventors: F. Richard Christ, Edward R. Zaleski