Abstract: Embodiments described herein describe a drug delivery device and a method of use thereof. The device includes a medicament container, a compressed gas container, an outlet, and a double-sided needle located within the housing. When a user presses an actuation button, the compressed air container is moved towards the medicament container and towards a proximal end of the double-sided needle. The double-sided needle pierces both the compressed gas container and the medicament container, opening fluid flow communication between the two containers, and causing medicament to be expelled out of the medicament container.

Abstract: Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

Abstract: Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

Abstract: A fluid delivery device includes: a fluid-filled cartridge comprising an outlet; a syringe comprising a substantially cylindrical syringe barrel having an open end and a fluid dispensing end; and a plunger rod configured to be received within the open end of the syringe barrel. The plunger rod comprises: a first end having a sealing member provided in sealing engagement with an inner wall of the syringe barrel such that a first syringe chamber is provided between the first end of the plunger rod and the fluid dispensing end of the syringe barrel; a second end extending out of the open end of the syringe barrel and having a cartridge-receiving chamber having a connection mechanism positioned therein for connecting the outlet of the cartridge thereto. The plunger rod also includes a fluid channel extending from the connection mechanism to the first end of the plunger rod.

Abstract: The present disclosure relates to a system and kit for preparing a reconstitutable cytotoxic pharmaceutical formulation within a closed system to prevent unintended contact with or release of the cytotoxic pharmaceutical formulation. A safety connector and a vial adapter are provided, which include check valves that prevent the unintended release of the cytotoxic pharmaceutical formulation. Also disclosed herein are methods of using the system and kit.

Abstract: A medication component mixing system is formed of a first syringe, such as a female syringe, and a second syringe such as a male syringe, wherein the system is configured to mix a female portion and a male portion of the medication. The female syringe and the male syringe mechanically couple to one another in an end-to-end fashion for mixing of the contents of the female and male portions.

Abstract: A device (200) for mixing first and second substances. The device comprises a first container (100) for storage of the first substance and a second container (150) received in the first container (100) and for storage of the second substance. An outlet (112) is disposed at the distal end of the first container (100). Valve means (180) are provided for closing a distal end of the second container (150) and a proximal end of the first container (100). A stopper means (166) closes a proximal end of the second chamber (152) and is movable with respect to the second container (150). An operating mechanism drives relative movement between the first and second containers for causing displacement of the second substance into the first chamber (102) through the valve means (180) when the outlet (112) is closed, for mixing the first and second substances in a mixing stroke of the device.

Abstract: A cartridge for dispensing a pre-measured buffering agent together with a medical fluid such as dental anesthetic. The cartridge includes a sharp piercing element at one end, a frangible barrier proximate the piercing element, and a traveling closure. The buffering solution is in a chamber between the barrier and the closure. When loaded into a syringe and subjected to operating pressures, the barrier is pierced, enabling the buffering solution to mix with the medical fluid. Continued pressure propels a desired, controlled mixture into a tissue of a patient. A dye may be included for visual confirmation of mixing. The invention may be regarded as the cartridge, a syringe having the cartridge, or a kit, with or without a syringe, or cartridges having closures of different types.

Abstract: A device for storage of a monomer liquid and a cement powder as starting components of a bone cement dough and for mixing the starting components, and for dispensing the mixed bone cement dough. The device includes a receptacle in which a monomer liquid container is arranged and a cartridge containing the cement powder. A feed plunger is arranged in the receptacle. A dispensing plunger is arranged between the monomer liquid container and the cement powder in the cartridge. The feed plunger can be punctured by a rod when motion of the feed plunger is blocked, whereby the dispensing plunger is propelled by propelling the rod further through the blocked and punctured feed plunger. Also provided are an extrusion device for propelling a feed plunger and a dispensing plunger of a device for mixing of a bone cement dough, and a method for the production of a bone cement dough.

Abstract: Embodiments described herein describe a drug delivery device. The device includes a medicament container, a compressed gas container, an outlet, and a double-sided needle located within the housing. When a user presses an actuation button, the compressed air container is moved towards the medicament container and towards a proximal end of the double-sided needle. The double-sided needle pierces both the compressed gas container and the medicament container, opening fluid flow communication between the two containers, and causing medicament to be expelled out of the medicament container.

Abstract: An elastic and sliding valvular joint for pre-filled syringes, which comprises a single chamber with an injectable product or two chambers that contain isolated products to be mixed before the injection is described. The valvular joint acts as a temporary closure, which prevents the internal chamber from communicating with the outside, or between both internal chambers. The joint comprises two discoid cooperative elements arranged on the syringe and with its edge against the internal surface: an elastic discoid plug and a sliding receiving discoid seat. The receiving discoid seat includes a central passage tube facing the hollow cylinder, and the elastic base of the plug fits in a removable manner inside a cylindrical cavity of the opening of the central passage tube of the seat.

Abstract: Mixing group for mixing two compounds to obtain a mixture, such as bone cement or an acrylic resin or a hydraulic cement, including: a first component having a substantially tubular body and delimiting a first housing zone of a first compound to be mixed, the first component having a first end as well as a second end, a second component with substantially tubular body and delimiting a second housing zone, the second component having a third end as well as a fourth end, the second component being set to contain a second compound to be mixed or a vial for containing a second compound to be mixed, the first housing zone being in fluid communication with the second housing zone, so as to allow the passage of the second compound from the second housing zone to the first housing zone.

Abstract: An adaptor for coupling with a medical container, including: a tubular body receiving a pierceable elastomeric piece, defining an inner cavity of the adaptor, the pierceable elastomeric piece being movable within the tubular body between a first position, in which a distal part of the pierceable elastomeric piece forms a seal of the cavity, and a second position, proximally spaced from the first position, in which the distal part opens the seal of the cavity, an air inlet, a filtering system for filling the inner cavity with decontaminated air, and a gripping member for securing the adaptor to the medical container. Also, an assembly comprising such an adaptor and a medical container.

Abstract: One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; and a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially inserted into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber.

Abstract: A syringe for mixing two substances which have been retained separately inside the syringe is described, for instance in a storage condition. The syringe is used for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment, a syringe for retaining and mixing first and second substances comprises a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane, wherein the syringe is configured such that the membrane and the pointed member are axially slidable in relation to each other.

Abstract: An access port for providing subcutaneous access to a patient is disclosed. In one embodiment, the port includes an internal body defining a fluid cavity that is accessible via a septum. A compliant outer cover including silicone is disposed about at least a portion of the body. A flange is included with the port body and is covered by the outer cover. The flange radially extends about a perimeter of the port body proximate the septum so as to impede penetration of a needle substantially into the outer cover in instances where the needle misses the septum. The flange can further include both an anchoring feature for securing the outer cover to the port body and an identification feature observable via x-ray imaging technology for conveying information indicative of at least one attribute of the access port. The outer cover provides a suitable surface for application of an antimicrobial/antithrombotic coating.

Abstract: A safety connector has a needle, and includes a tubular protective sleeve with a distal section, having a movable wall portion arranged in the peripheral wall thereof. The movable wall portion is selectively movable between a retracted position and a protection position. In the retracted position, the movable wall portion is aligned with the peripheral wall of the proximal section of the tubular protective sleeve. In the protection position, the movable wall portion projects into the inner space of the tubular protective sleeve.

Abstract: A syringe system, piston seal systems, stopper systems, and methods for assembling and using the syringe systems. The piston seal system including a piston seal member and a piston head member. The injection system including a container, a piston seal system positioned within the container, and a stopper system coupled to an end of the container. The method of assembling an injection system, the method includes obtaining a container, a piston seal system, and a stopper system. The method also includes inserting the piston seal system into a cavity within the container. The method further includes securing the stopper system at an end of the container in an opening of the cavity. Methods of using the syringe system, piston seal systems, and stopper systems are also disclosed.

Abstract: A system for mixing drug products and injecting includes a syringe body, proximal and distal stopper members disposed in the syringe body, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The proximal and distal stopper members form a proximal drug chamber between there between and a distal drug chamber between the distal stopper member and a distal end of the syringe body. The plunger member includes a needle retention feature, an energy-storage member, and an energy-storage member latching member all disposed in disposed in a plunger interior. First and second sizes of the respective proximal and distal drug chambers can be modified by movement of the proximal and distal stopper members relative to the syringe body. The needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body.

Abstract: A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.

Abstract: Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

Abstract: A fluid delivery device includes: a fluid-filled cartridge comprising an outlet; a syringe comprising a substantially cylindrical syringe barrel having an open end and a fluid dispensing end; and a plunger rod configured to be received within the open end of the syringe barrel. The plunger rod comprises: a first end having a sealing member provided in sealing engagement with an inner wall of the syringe barrel such that a first syringe chamber is provided between the first end of the plunger rod and the fluid dispensing end of the syringe barrel; a second end extending out of the open end of the syringe barrel and having a cartridge-receiving chamber having a connection mechanism positioned therein for connecting the outlet of the cartridge thereto. The plunger rod also includes a fluid channel extending from the connection mechanism to the first end of the plunger rod.

Abstract: Injection systems with storage compartments to house various materials are described. The storage compartments facilitate provision of medical care in space- and time-efficient manners and are particularly useful in providing care in non-medical facilities.

Abstract: A syringe includes a hollow body, a piston and a seal. The hollow body has a surrounding hollow body surface and forms a passage therein. An axis is formed in an axial longitudinal direction of the hollow body and the passage has a rear body opening and a front body opening arranged opposite to one another in the longitudinal direction. A first needle seat is formed at the front body opening, in which a needle cannula is arranged and relative to which the needle cannula is movable along the axis. The piston is arranged in the hollow body and is movable in the passage along the axis. The seal is able to be cancelled such that a receiving chamber and a supply space of the syringe are in flow communication in a release position.

Abstract: A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.

Abstract: A removable cap for use with an auto-injector device, whereupon removal of the cap triggers an actuating assembly that can cause an automatic mixing of medicament components in an auto-injector device and/or place the auto-injector in a state to be used.

Abstract: An injection device is provided with dual medicament chambers and a mixing pen needle assembly, whereby predetermined dosages of two medicaments can be provided to a mixing reservoir in the pen needle assembly and delivered simultaneously with the injection device.

Abstract: A portable auto-injector is capable of moving from a compact state where the auto-injector is in a shape easier to transport than in an activation state wherein the auto-injector has been extended. A safety limits movement of the needle assembly and prevents premature needle sticks. The drug is stored in one or more dry and wet medicament states until need.

Abstract: A dispenser is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials that may react upon exposure to air, such as glue. Means are provided in the dispenser to effect controlled delivery of a pre-determined amount of the substance contained in the dispenser. A one-way valve is provided to hermetically seal the portion of the dispenser containing the substance to be dispensed.

Abstract: A bottle for the creation, storage, administration and dispensing of elemental iodine is disclosed. An amount of crystal iodine is safely housed at the bottom of the bottle. Water is poured into the bottle and contacts with the crystal iodine to form elemental iodine. With the crystal iodine safely secured at the bottom of the housing, the formed elemental iodine maintains contact with the crystal iodine to maintain its stability and extends is shelf life. Several dispensing device are also disclosed for dispensing or administering the elemental iodine, as needed, in order to treat internal and external areas of a human's or animal's body.

Abstract: The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament contained within a capsule having an integral flow distributor/distribution system and where both medicaments are delivered through a single hollow needle.

Abstract: A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and

Abstract: A drug delivery system to deliver two or more medicaments operable through a auto-injector drug delivery device and a single dispense interface. The device comprises a housing defining a primary reservoir containing a first medicament. A dosing mechanism operably connected to the primary reservoir. A single dispense interface is configured for fluid communication with the primary reservoir and a secondary reservoir of medicament containing at least one drug agent configured for fluid communication to the single dispense interface. A single activation of the dosing mechanism causes medicament from the primary reservoir and a non-user settable dose of the second medicament to be expelled through the single dispense interface.

Abstract: A multi-purpose syringe that may be used both for gravity feeding and syringe pump assisted feeding of a neonate is disclosed. The multi-purpose syringe includes a cap and a plunger. The cap and plunger may be selectively engaged to the barrel depending on whether the neonate is fed by gravity or syringe pump. The cap seals the top of the barrel but allows gas to pass between the inside of the barrel and the environment and traps liquid within the barrel. To this end, the cap has an aperture covered by a hydrophobic member.

Abstract: A metering device is used for the metered administration of a flowable preparation together with a flowable carrier medium. A storage container for the preparation has at least one access opening. A metering plunger body can be moved in a sealed manner in the storage container between a starting position and at least one metering position. The metering plunger body is hollow. A metering sleeve has on a bottom side an eccentric metering sleeve opening. An inner plunger body has on the bottom side an eccentrically arranged plunger body opening. In a through relative rotation position of the metering sleeve relative to the inner plunger body a passage is provided between the inside of the storage container and the inside of the inner plunger body. In a closed relative rotational position this passage is closed. This results in a user-friendly and compact metering device.

Abstract: A prefilled syringe of a before-use mixing type not requiring a bypass portion defined by a recessed inner surface portion of an outer cylinder, including first and second gaskets (4,5) fitted in the outer cylinder (2), and non-rotatively and complementarily shaped engagement portions (12, 13) respectively at a front end of the first gasket (4) and a rear end of the second gasket (5) to reduce the period for transferring a liquid between two chambers separated by the gaskets. During storage, the engagement portions abut each other to be kept out of engagement with each other, whereby a drug containing space is defined between the gaskets. When a liquid is transferred from a space defined on a rear side of the first gasket (4) to the drug containing space, the internal pressure of the drug containing space is prevented from being excessively increased.

Abstract: A one-part reconstitution device is described, for temporarily separating two substances into two compartments within a cartridge or syringe and allowing for mixture of the two substances within the cartridge or syringe. In various embodiments, the one-part reconstitution device may include an outer, contact portion configured to contact an inner surface of the cartridge or syringe, and an inner, deflection portion positioned within the contact portion. The deflection portion may be movable from a locked position, in which the deflection portion causes the contact portion to exert a first radial force against the inner surface, to an unlocked position, in which the deflection portion causes the contact portion to exert a second radial force against the inner surface. The second radial force may be less than the first radial force, and the contact portion and the deflection portion may comprise one part.

Abstract: A vial access device includes a housing having first and second connectors. The first connector is configured to be secured to a first container and the second connector is configured to be secured to a second container. The vial access device further includes a spike member extending from the housing and having a proximal end and a distal end. The spike member defines a vent lumen and a fluid lumen spaced from the vent lumen with each of the vent lumen and the fluid lumen having a distal opening. A shape defined by a circumference of the spike member is only symmetric about one axis at a position between the proximal end of the spike member and the distal opening of the fluid lumen.

Abstract: A carpule for a dental syringe provides an internal piston disposed between a front septum and a rear plunger. The internal piston is hollow and includes a thin membrane front. The internal piston is designed to offer minimum resistance to movement in the carpule body to allow for aspiration and for easy dispensing. The internal piston divides the carpule into two anesthetic chambers, allowing an anesthetic without a vasoconstrictor and an anesthetic with a vasoconstrictor to be dispensed sequentially in a single injection and without causing undue trauma to the patient.

Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.

Abstract: A prefilled syringe of a before-use mixing type is provided, which does not require a bypass portion defined by a recessed inner surface portion of an outer cylinder. In the prefilled syringe, a first gasket (4) and a second gasket (5) are fitted in the outer cylinder (2), and non-rotatively and complementarily shaped engagement portions (12), (13) are respectively provided at a front end of the first gasket (4) and a rear end of the second gasket (5) in order to reduce a liquid transfer period required for transferring a liquid between two chambers separated by the gaskets. During storage, the engagement portions (12), (13) abut against each other to be kept out of engagement with each other, whereby a drug containing space is defined between the gaskets (4), (5). When a liquid is transferred from a liquid containing space defined on a rear side of the first gasket (4) to the drug containing space, the internal pressure of the drug containing space is prevented from being excessively increased.

Abstract: A method for transferring and mixing a pharmaceutical mixture utilizing a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.

Abstract: A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.

Abstract: A steroid delivery system including a mixing syringe having a first chamber and a second chamber and at least one hypodermic needle is provided. The first chamber of the mixing syringe contains a pre-measured volume of a local anesthetic and the second chamber contains a pre-measured volume of a corticosteroid. An improved mixing syringe and a method for treating pain using the steroid delivery system of the present invention is also provided herein. The improved syringe achieves mixing without the introduction or elimination of air and without puncturing or rupturing of a membrane, diaphragm or other material. The kit concept improves the speed of the procedure, sterility, accuracy of dosing, and immediate availability of disparate items to implement the procedure in a variety of medical practice settings.

Abstract: The connector for a fluid line of an extracorporeal circuit comprises a tubular body which internally defines a fluid passage, a first connection port predisposed for coupling to the fluid line, a second connection port predisposed for coupling to a male Luer connector borne by an external element, and a closure element of the second connection port. The closure element is formed of a breakable membrane made in a single piece with the tubular body. On coupling, the membrane is broken by the truncoconical projection of the male Luer connector. The connector connects a service line of an extracorporeal circuit to a pressure sensor of a dialysis machine.

Abstract: A device for mixing and applying a substance includes a syringe barrel, a plunger, a shaft, a mixing surface, and a locking device. The syringe barrel is preloaded with one or more components of the substance and is enclosed by a seal. The plunger has a plunger body that is displaceable within the syringe barrel, and a dispensing surface. The shaft within the plunger body has a first end and a second end, and is positioned to extend through and from the plunger body. The mixing surface is attached to the first end of the shaft. The locking device enables the mixing surface to alternate between an extended position and a retracted position. In the extended position, the mixing surface projects from the dispensing surface to promote mixing of the substance. In the retracted position, the mixing surface is retracted through the dispensing surface into the plunger body.

Abstract: An administration device comprises a container and a mixing device for mixing an active substance (in a first chamber) with a dilution liquid (in a second chamber). The container has a membrane seal at one end and is combined with a mixing device for mixing the active substance. The administration device has an injection needle unit with a distal needle portion facing away from the container for piercing the skin, and disposed opposite thereto is a proximal needle portion facing the membrane when the administration device is in the initial position, which is thrust through the membrane into the container in a mixing position. The administration device includes a protective sleeve arranged coaxially about the injection needle, movable from the initial position only in the proximal direction relative to the container. The protective sleeve can be non-rotatably connected to the container in the mixing position and rotated relative to the mixing device to perform mixing.

Abstract: A combining syringe wherein multiple fluids are dispensed through a primary plunger into a primary cylinder when a force is applied to the secondary plunger shaft. The fluids are combined and dispensed from the primary cylinder's attaching end when a force is applied to the primary plunger shaft. The primary plunger shaft has a primary plunger attaching end opposite a primary pressure applying end. The primary plunger is connected to the primary plunger attaching end. The primary plunger shaft accepts a secondary cylinder and secures it with an attaching element. The secondary cylinder has a secondary plunger receiving end opposite a dispensing end. The secondary cylinder's dispensing end is inserted into an opening of the primary plunger. The secondary plunger shaft has a secondary plunger attaching end opposite a secondary pressure applying end. The secondary plunger is connected to the secondary plunger attaching end.

Abstract: An injector (10) for injecting a medicament into a patient. The injector includes a container (18) defining a first chamber (22), which contains a fluid therein, and a second chamber (23). The injector also includes an injection conduit (126) configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source (62) is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.